Andreas Ritsch

Summary

Affiliation: Innsbruck Medical University
Country: Austria

Publications

  1. pmc Inhibition of hepatic scavenger receptor-class B type I by RNA interference decreases atherosclerosis in rabbits
    Egon Demetz
    Department of Internal Medicine I, Innsbruck Medical University, Innsbruck, Austria
    Atherosclerosis 222:360-6. 2012
  2. pmc Cholesteryl ester transfer protein and mortality in patients undergoing coronary angiography: the Ludwigshafen Risk and Cardiovascular Health study
    Andreas Ritsch
    Department of Internal Medicine I, Innsbruck Medical University, Anichstrasse 35, A 6020 Innsbruck, Austria
    Circulation 121:366-74. 2010
  3. doi request reprint The K121Q polymorphism of ENPP1 and peripheral arterial disease
    Philipp Eller
    Department of Internal Medicine, Medical University Innsbruck, Anichstrasse 35, 6020, Innsbruck, Austria
    Heart Vessels 23:104-7. 2008
  4. pmc The thyromimetic T-0681 protects from atherosclerosis
    Ivan Tancevski
    Department of Internal Medicine, Innsbruck Medical University, Innsbruck, Austria
    J Lipid Res 50:938-44. 2009
  5. pmc The liver-selective thyromimetic T-0681 influences reverse cholesterol transport and atherosclerosis development in mice
    Ivan Tancevski
    Department of Internal Medicine, Innsbruck Medical University, Innsbruck, Austria
    PLoS ONE 5:e8722. 2010
  6. ncbi request reprint Phospholipid transfer protein augments apoptosis in THP-1-derived macrophages induced by lipolyzed hypertriglyceridemic plasma
    Andreas Wehinger
    Department of Internal Medicine, Medical University Innsbruck, Innsbruck, Austria
    Arterioscler Thromb Vasc Biol 27:908-15. 2007
  7. pmc Reduced plasma high-density lipoprotein cholesterol in hyperthyroid mice coincides with decreased hepatic adenosine 5'-triphosphate-binding cassette transporter 1 expression
    Ivan Tancevski
    Department of Internal Medicine, Innsbruck Medical University, Anichstrasse 35, Innsbruck, Austria
    Endocrinology 149:3708-12. 2008
  8. pmc Influence of aspirin on SR-BI expression in human carotid plaques
    Andreas Wehinger
    Department of Internal Medicine, Innsbruck Medical University, Anichstrasse 35, Innsbruck, Austria
    Atherosclerosis 206:234-8. 2009
  9. doi request reprint The MTP -493TT genotype is associated with peripheral arterial disease: results from the Linz Peripheral Arterial Disease (LIPAD) Study
    Wilfried Schgoer
    Department of Internal Medicine, Medical University Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria
    Clin Biochem 41:712-6. 2008
  10. ncbi request reprint Scavenger receptor class B type I polymorphisms and peripheral arterial disease
    Andreas Ritsch
    Department of Medicine, Innsbruck Medical University, A 6020 Innsbruck, and Department of Laboratory Medicine, Konventhospital Barmherzige Brueder, Linz, Austria
    Metabolism 56:1135-41. 2007

Collaborators

Detail Information

Publications30

  1. pmc Inhibition of hepatic scavenger receptor-class B type I by RNA interference decreases atherosclerosis in rabbits
    Egon Demetz
    Department of Internal Medicine I, Innsbruck Medical University, Innsbruck, Austria
    Atherosclerosis 222:360-6. 2012
    ..We investigated the in vivo impact of hepatic SR-BI inhibition on lipoprotein metabolism and the development of atherosclerosis employing RNA interference...
  2. pmc Cholesteryl ester transfer protein and mortality in patients undergoing coronary angiography: the Ludwigshafen Risk and Cardiovascular Health study
    Andreas Ritsch
    Department of Internal Medicine I, Innsbruck Medical University, Anichstrasse 35, A 6020 Innsbruck, Austria
    Circulation 121:366-74. 2010
    ..In this report, we present a prospective observational study of patients referred to coronary angiography in which CETP was examined in relation to morbidity and mortality...
  3. doi request reprint The K121Q polymorphism of ENPP1 and peripheral arterial disease
    Philipp Eller
    Department of Internal Medicine, Medical University Innsbruck, Anichstrasse 35, 6020, Innsbruck, Austria
    Heart Vessels 23:104-7. 2008
    ....
  4. pmc The thyromimetic T-0681 protects from atherosclerosis
    Ivan Tancevski
    Department of Internal Medicine, Innsbruck Medical University, Innsbruck, Austria
    J Lipid Res 50:938-44. 2009
    ..Our data suggest that liver-selective thyromimetics, such as T-0681, may prove to be useful therapeutic agents against the development of atherosclerosis in humans...
  5. pmc The liver-selective thyromimetic T-0681 influences reverse cholesterol transport and atherosclerosis development in mice
    Ivan Tancevski
    Department of Internal Medicine, Innsbruck Medical University, Innsbruck, Austria
    PLoS ONE 5:e8722. 2010
    ....
  6. ncbi request reprint Phospholipid transfer protein augments apoptosis in THP-1-derived macrophages induced by lipolyzed hypertriglyceridemic plasma
    Andreas Wehinger
    Department of Internal Medicine, Medical University Innsbruck, Innsbruck, Austria
    Arterioscler Thromb Vasc Biol 27:908-15. 2007
    ..We hypothesized that by integrating surface remnants into HDL, phospholipid transfer protein (PLTP) alleviates cytotoxicity...
  7. pmc Reduced plasma high-density lipoprotein cholesterol in hyperthyroid mice coincides with decreased hepatic adenosine 5'-triphosphate-binding cassette transporter 1 expression
    Ivan Tancevski
    Department of Internal Medicine, Innsbruck Medical University, Anichstrasse 35, Innsbruck, Austria
    Endocrinology 149:3708-12. 2008
    ....
  8. pmc Influence of aspirin on SR-BI expression in human carotid plaques
    Andreas Wehinger
    Department of Internal Medicine, Innsbruck Medical University, Anichstrasse 35, Innsbruck, Austria
    Atherosclerosis 206:234-8. 2009
    ..We recently showed that aspirin promotes scavenger receptor class-B type I (SR-BI) protein expression in vitro in primary human macrophages and in vivo in resident peritoneal macrophages of mice...
  9. doi request reprint The MTP -493TT genotype is associated with peripheral arterial disease: results from the Linz Peripheral Arterial Disease (LIPAD) Study
    Wilfried Schgoer
    Department of Internal Medicine, Medical University Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria
    Clin Biochem 41:712-6. 2008
    ..We hypothesized the -493T single nucleotide polymorphism in the MTP promoter region to be associated with altered lipoprotein levels and with presence of peripheral arterial disease (PAD)...
  10. ncbi request reprint Scavenger receptor class B type I polymorphisms and peripheral arterial disease
    Andreas Ritsch
    Department of Medicine, Innsbruck Medical University, A 6020 Innsbruck, and Department of Laboratory Medicine, Konventhospital Barmherzige Brueder, Linz, Austria
    Metabolism 56:1135-41. 2007
    ..In conclusion, in the present study population, SCARB1 polymorphisms not only show associations with plasma levels of total and low-density lipoprotein cholesterol, respectively, but also with the risk for PAD...
  11. doi request reprint Effects of weight loss on lipid transfer proteins in morbidly obese women
    Markus W Laimer
    Department of Internal Medicine I, Medical University Innsbruck, Anichstrasse 35, 6020, Innsbruck, Austria
    Lipids 44:1125-30. 2009
    ..This improvement may be attributable to decreased mass and action of the adipocyte tissue derived lipid transfer proteins CETP and PLTP...
  12. doi request reprint The Taq1B-variant in the cholesteryl ester-transfer protein gene and the risk of metabolic syndrome
    Anton Sandhofer
    Clinical Department of Internal Medicine, Clinical Division of General Internal Medicine, Medical University Innsbruck, Anichstrasse, Innsbruck, Austria
    Obesity (Silver Spring) 16:919-22. 2008
    ..43 (0.26-0.72), P = 0.001). Furthermore, the risk reduction was more pronounced in men than in women. We conclude that CETP plays an important role in the metabolic syndrome, possibly involving novel functions of CETP...
  13. ncbi request reprint Phage-displayed recombinant single-chain antibody fragments with high affinity for cholesteryl ester transfer protein (CETP): cDNA cloning, characterization and CETP quantification
    Andreas Ritsch
    Department of Medicine, University of Innsbruck, Innsbruck, Austria
    Clin Chem Lab Med 42:247-55. 2004
    ....
  14. ncbi request reprint Hepatic ENPP1 expression is induced in diabetic rabbits
    Philipp Eller
    Department of Internal Medicine, Division of General Internal Medicine, Medical University Innsbruck, Anichstrasse 35, 6020, Innsbruck, Austria
    Mamm Genome 17:886-91. 2006
    ..We provide further molecular information about ENPP1 as a potential pharmacologic target and characterize its regulation in an insulin-dependent diabetes mellitus animal model...
  15. ncbi request reprint Cholesteryl ester transfer protein in metabolic syndrome
    Anton Sandhofer
    Clinical Department of Internal Medicine, Clinical Division of General Internal Medicine, Medical University Innsbruck, Innsbruck, Anichstrasse 35, A 6020 Innsbruck, Austria
    Obesity (Silver Spring) 14:812-8. 2006
    ..The aim of this study was to investigate the role of CETP in subjects with MS...
  16. ncbi request reprint Impact of ENPP1 genotype on arterial calcification in patients with end-stage renal failure
    Philipp Eller
    Department of Internal Medicine, Division of General Internal Medicine, Innsbruck Medical University, Innsbruck, Austria
    Nephrol Dial Transplant 23:321-7. 2008
    ..Inactivating mutations of ENPP1 are associated with generalized arterial calcification of infancy. We hypothesized the ENPP1 K121Q variant to be associated with increased vascular calcification in patients with end-stage renal failure...
  17. ncbi request reprint Increased plasma levels of LDL cholesterol in rabbits after adenoviral overexpression of human scavenger receptor class B type I
    Ivan Tancevski
    Department of Internal Medicine, Innsbruck Medical University, Anichstrasse 35, 6020, Innsbruck, Austria
    J Mol Med (Berl) 83:927-32. 2005
    ..The role of SR-BI in lipoprotein metabolism and atherogenesis in rabbits--a CETP-expressing animal model displaying a manlike lipoprotein profile--may therefore be different from the one found in rodents...
  18. ncbi request reprint Aspirin regulates expression and function of scavenger receptor-BI in macrophages: studies in primary human macrophages and in mice
    Ivan Tancevski
    Department of Internal Medicine, Innsbruck Medical University, Anichstrasse 35, Innsbruck 6020, Austria
    FASEB J 20:1328-35. 2006
    ..We could show that COX-independent effects of aspirin were able to enhance expression of SR-BI in macrophages in a post-transcriptional, PPAR-alpha independent way, suggesting a novel pharmacologic effect of aspirin...
  19. doi request reprint Cadmium is a novel and independent risk factor for early atherosclerosis mechanisms and in vivo relevance
    Barbara Messner
    Cardiac Surgery Research Laboratory, Department of Cardiac Surgery, Innsbruck Medical University, Austria
    Arterioscler Thromb Vasc Biol 29:1392-8. 2009
    ..Although cadmium (Cd) is an important and common environmental pollutant and has been linked to cardiovascular diseases, little is known about its effects in initial stages of atherosclerosis...
  20. ncbi request reprint In vivo application of adenoviral vectors purified by a Taqman Real Time PCR-supported chromatographic protocol
    Ivan Tancevski
    Department of Internal Medicine, Innsbruck Medical University, Anichstrasse 35, A 6020 Innsbruck, Austria
    Int J Biol Macromol 39:77-82. 2006
    ..No alterations of liver enzymes and C-reactive protein (CRP) upon Source15 Q adenovirus treatment could be detected, demonstrating biological safety of our protocol...
  21. doi request reprint Cholesteryl ester transfer protein in patients with coronary heart disease
    Kristina Duwensee
    Department of Internal Medicine I, Innsbruck Medical University, Innsbruck, Austria
    Eur J Clin Invest 40:616-22. 2010
    ..In this study, we analyse associations of CETP with cardiovascular endpoints in a cohort of patients with stable coronary artery disease (CAD)...
  22. ncbi request reprint Fibrates ameliorate the course of bacterial sepsis by promoting neutrophil recruitment via CXCR2
    Ivan Tancevski
    Department of Internal Medicine VI Infectious Diseases, Immunology, Rheumatology, Pneumology, Innsbruck Medical University, Innsbruck, Austria
    EMBO Mol Med 6:810-20. 2014
    ..Our results unravel a novel function of fibrates in innate immunity and host response to infection and suggest fibrates as a promising adjunct therapy in bacterial sepsis...
  23. pmc Leoligin, the major lignan from Edelweiss, activates cholesteryl ester transfer protein
    Kristina Duwensee
    Department of Internal Medicine I, Innsbruck Medical University, Innsbruck, Austria
    Atherosclerosis 219:109-15. 2011
    ..Cholesteryl ester transfer protein (CETP) plays a central role in the metabolism of high-density lipoprotein particles. Therefore, we searched for new drugs that bind to CETP and modulate its activity...
  24. ncbi request reprint Alternative splicing of vasohibin-1 generates an inhibitor of endothelial cell proliferation, migration, and capillary tube formation
    Johann Kern
    Laboratory of Tumor Biology and Angiogenesis, Division of Hematology and Oncology, Innsbruck Medical University, Innrain 66, A 6020 Innsbruck, Austria
    Arterioscler Thromb Vasc Biol 28:478-84. 2008
    ....
  25. ncbi request reprint Cholesteryl ester transfer protein: gathering momentum as a genetic marker and as drug target
    Andreas Ritsch
    Department of Medicine, University of Innsbruck, Innsbruck, Austria
    Curr Opin Lipidol 14:173-9. 2003
    ..The question as to whether cholesteryl ester transfer protein promotes or protects from atherosclerosis, however, has not been answered...
  26. pmc The resurgence of thyromimetics as lipid-modifying agents
    Ivan Tancevski
    Innsbruck Medical University, Department of Internal Medicine, Anichstrasse 35, Innsbruck 6020, Austria
    Curr Opin Investig Drugs 10:912-8. 2009
    ..Importantly, data from ongoing clinical trials have provided the first evidence that selective thyromimetics may also reduce the levels of plasma cholesterol in humans...
  27. ncbi request reprint The neuropeptide secretoneurin acts as a direct angiogenic cytokine in vitro and in vivo
    Rudolf Kirchmair
    Department of Internal Medicine, University of Innsbruck, Innsbruck, Austria
    Circulation 109:777-83. 2004
    ..Secretoneurin is an abundant neuropeptide of the central, peripheral, and autonomic nervous systems, located in nerve fibers characterized by a close interaction with blood vessels and known to stimulate endothelial cell migration...
  28. ncbi request reprint Enhancement of cholesteryl ester transfer in plasma by hormone-replacement therapy
    Andreas Ritsch
    Department of Medicine, University of Innsbruck, Anichstrasse 35, A 6020 Innsbruck, Austria
    Metabolism 51:599-604. 2002
    ....
  29. ncbi request reprint Selective imaging of saturated and unsaturated lipids by wide-field CARS-microscopy
    Christoph Heinrich
    Division for Biomedical Physics, Innsbruck Medical University, Mullerstr 44, A 6020 Innsbruck, Austria
    Opt Express 16:2699-708. 2008
    ..For this purpose we draw advantage of the high signal-to-noise ratio of wide-field CARS microscopy that is achieved by an excitation geometry involving a "sheet-of-light"-type illumination...
  30. ncbi request reprint A gel filtration assay to determine glycogen synthase activity
    Andreas Niederwanger
    Clinical Department of Internal Medicine, Medical University of Innsbruck, Anichstrasse 35, A 6020 Innsbruck, Austria
    J Chromatogr B Analyt Technol Biomed Life Sci 820:143-5. 2005
    ..In addition to high precision and sensitivity, the method's additional salient advantages include lesser expenditure of time and labour and reduced exposure time of the personnel to radioactivity...