Markus Reindl

Summary

Affiliation: Innsbruck Medical University
Country: Austria

Publications

  1. pmc Cerebrospinal fluid B cells correlate with early brain inflammation in multiple sclerosis
    Bettina Kuenz
    Clinical Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    PLoS ONE 3:e2559. 2008
  2. pmc Patterns of antibody binding to aquaporin-4 isoforms in neuromyelitis optica
    Simone Mader
    Clinical Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    PLoS ONE 5:e10455. 2010
  3. doi request reprint The spectrum of MOG autoantibody-associated demyelinating diseases
    Markus Reindl
    Clinical Department of Neurology, Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, Austria
    Nat Rev Neurol 9:455-61. 2013
  4. doi request reprint Diagnostic biomarkers in multiple sclerosis
    Bettina Kuenz
    Innsbruck Medical University, Clinical Department of Neurology, Anichstrasse 35, A 6020 Innsbruck, Austria 43 512 504 24363 43 512 504 24266
    Expert Opin Med Diagn 1:225-33. 2007
  5. pmc An antibody microarray analysis of serum cytokines in neurodegenerative Parkinsonian syndromes
    Philipp Mahlknecht
    Clinical Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    Proteome Sci 10:71. 2012
  6. doi request reprint B cells and antibodies in MS
    Markus Reindl
    Neuroimmunological and Multiple Sclerosis Clinic and Research Unit, Clinical Department of Neurology, Innsbruck Medical University, Anichstrasse 35, A 6020 Innsbruck, Austria
    Results Probl Cell Differ 51:99-113. 2010
  7. pmc Nogo-B is associated with cytoskeletal structures in human monocyte-derived macrophages
    Kathrin Schanda
    Clinical Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    BMC Res Notes 4:6. 2011
  8. ncbi request reprint Epitope specificity of serum antibodies directed against the extracellular domain of myelin oligodendrocyte glycoprotein: Influence of relapses and immunomodulatory treatments
    Michael Khalil
    Clinical Department of Neurology, Innsbruck Medical University, Anichstrasse 35, A 6020 Innsbruck, Austria
    J Neuroimmunol 174:147-56. 2006
  9. ncbi request reprint Increased serum levels of soluble CD14 indicate stable multiple sclerosis
    Andreas Lutterotti
    Clinical Department of Neurology, Innsbruck Medical University, Anichstrasse 35, A 6020 Innsbruck, Austria
    J Neuroimmunol 181:145-9. 2006
  10. doi request reprint Features of intrathecal immunoglobulins in patients with multiple sclerosis
    Franziska Di Pauli
    Clinical Department of Neurology, Innsbruck Medical University, Anichstrasse 35, A 6020 Innsbruck, Austria
    J Neurol Sci 288:147-50. 2010

Detail Information

Publications61

  1. pmc Cerebrospinal fluid B cells correlate with early brain inflammation in multiple sclerosis
    Bettina Kuenz
    Clinical Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    PLoS ONE 3:e2559. 2008
    ..There is accumulating evidence from immunological, pathological and therapeutic studies that B cells are key components in the pathophysiology of multiple sclerosis (MS)...
  2. pmc Patterns of antibody binding to aquaporin-4 isoforms in neuromyelitis optica
    Simone Mader
    Clinical Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    PLoS ONE 5:e10455. 2010
    ..Serum NMO-IgG autoantibodies (Abs), a specific finding in NMO patients, target the water channel protein aquaporin-4 (AQP4), which is expressed as a long (M-1) or a short (M-23) isoform...
  3. doi request reprint The spectrum of MOG autoantibody-associated demyelinating diseases
    Markus Reindl
    Clinical Department of Neurology, Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, Austria
    Nat Rev Neurol 9:455-61. 2013
    ..This Review article discusses the current literature on MOG antibodies, their potential clinical relevance, and their role in the pathogenesis of MOG antibody-associated demyelinating disorders. ..
  4. doi request reprint Diagnostic biomarkers in multiple sclerosis
    Bettina Kuenz
    Innsbruck Medical University, Clinical Department of Neurology, Anichstrasse 35, A 6020 Innsbruck, Austria 43 512 504 24363 43 512 504 24266
    Expert Opin Med Diagn 1:225-33. 2007
    ....
  5. pmc An antibody microarray analysis of serum cytokines in neurodegenerative Parkinsonian syndromes
    Philipp Mahlknecht
    Clinical Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    Proteome Sci 10:71. 2012
    ..abstract:..
  6. doi request reprint B cells and antibodies in MS
    Markus Reindl
    Neuroimmunological and Multiple Sclerosis Clinic and Research Unit, Clinical Department of Neurology, Innsbruck Medical University, Anichstrasse 35, A 6020 Innsbruck, Austria
    Results Probl Cell Differ 51:99-113. 2010
    ..This chapter therefore aims to summarize the present knowledge and to outline future directions about the role of B cells and antibodies in research and therapy of MS and NMO...
  7. pmc Nogo-B is associated with cytoskeletal structures in human monocyte-derived macrophages
    Kathrin Schanda
    Clinical Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    BMC Res Notes 4:6. 2011
    ..abstract:..
  8. ncbi request reprint Epitope specificity of serum antibodies directed against the extracellular domain of myelin oligodendrocyte glycoprotein: Influence of relapses and immunomodulatory treatments
    Michael Khalil
    Clinical Department of Neurology, Innsbruck Medical University, Anichstrasse 35, A 6020 Innsbruck, Austria
    J Neuroimmunol 174:147-56. 2006
    ..Recently experienced relapses intensified the anti-MOG peptide antibody response. Immunomodulatory treatment with interferon-beta or glatiramer-acetate had no major impact on the anti-MOG peptide immunoreactivity after 1 year of therapy...
  9. ncbi request reprint Increased serum levels of soluble CD14 indicate stable multiple sclerosis
    Andreas Lutterotti
    Clinical Department of Neurology, Innsbruck Medical University, Anichstrasse 35, A 6020 Innsbruck, Austria
    J Neuroimmunol 181:145-9. 2006
    ..An increased expression of sCD14 was also detected after treatment with interferon-beta. In summary, we report evidence that serum sCD14 levels are increased in MS and correlate inversely with disease activity in relapsing MS patients...
  10. doi request reprint Features of intrathecal immunoglobulins in patients with multiple sclerosis
    Franziska Di Pauli
    Clinical Department of Neurology, Innsbruck Medical University, Anichstrasse 35, A 6020 Innsbruck, Austria
    J Neurol Sci 288:147-50. 2010
    ..Finally, intrathecal IgG production (IgG1 and IgG3) correlated with the presence of mature B cells and plasma blasts...
  11. pmc Opposed circulating plasma levels of endothelin-1 and C-type natriuretic peptide in children with Plasmodium falciparum malaria
    Anelia Dietmann
    Clinical Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    Malar J 7:253. 2008
    ....
  12. doi request reprint Endoglin in African children with Plasmodium falciparum malaria: a novel player in severe malaria pathogenesis?
    Anelia Dietmann
    Clinical Department of Neurology, Innsbruck Medical University, 6020 Innsbruck, Austria
    J Infect Dis 200:1842-8. 2009
    ..Transforming growth factor beta (TGF-beta) family members are important regulators of inflammation that influence malaria pathogenesis. The soluble form of the auxiliary receptor endoglin (sEng) may play a role in malaria pathogenesis...
  13. doi request reprint Clinical and immunological follow-up of B-cell depleting therapy in CNS demyelinating diseases
    Viktoria Gredler
    Clinical Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    J Neurol Sci 328:77-82. 2013
    ..Relapses were not associated with re-emerging B-cells, serum levels of B-cell activating factor (BAFF) or AQP4-IgG titers. BAFF serum levels increased following rituximab treatment...
  14. pmc Complement activating antibodies to myelin oligodendrocyte glycoprotein in neuromyelitis optica and related disorders
    Simone Mader
    Clinical Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    J Neuroinflammation 8:184. 2011
    ....
  15. doi request reprint Striatal transplantation in a rodent model of multiple system atrophy: effects on L-Dopa response
    Martin Köllensperger
    Section for Clinical Neurobiology, Innsbruck Medical University, Innsbruck, Austria
    J Neurosci Res 87:1679-85. 2009
    ..Therefore, striatal transplantation should be further defined preclinically as a possible therapeutic option for patients with MSA-P and a failing L-Dopa response...
  16. ncbi request reprint Microglial activation mediates neurodegeneration related to oligodendroglial alpha-synucleinopathy: implications for multiple system atrophy
    Nadia Stefanova
    Clinical Neurobiology Unit, Neurodegeneration Research Laboratory, Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    Mov Disord 22:2196-203. 2007
    ....
  17. doi request reprint Temporal dynamics of anti-MOG antibodies in CNS demyelinating diseases
    Franziska Di Pauli
    Clinical Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    Clin Immunol 138:247-54. 2011
    ....
  18. doi request reprint Skeletal muscle involvement in friedreich ataxia and potential effects of recombinant human erythropoietin administration on muscle regeneration and neovascularization
    Wolfgang Nachbauer
    Departments of Neurology, Medical University Innsbruck, Innsbruck, Austria
    J Neuropathol Exp Neurol 71:708-15. 2012
    ..The rhuEPO-induced changes were subtle, but increased capillary density might result in improved oxygen supply and myofiber function...
  19. ncbi request reprint Serum and cerebrospinal fluid antibodies to Nogo-A in patients with multiple sclerosis and acute neurological disorders
    Markus Reindl
    Department of Neurology, University of Innsbruck, Anichstrasse 35, Innsbruck, 6020, Austria
    J Neuroimmunol 145:139-47. 2003
    ..We finally demonstrate that human anti-Nogo-A antibodies recognize native Nogo-A in brain extracts, oligodendrocytes and cells expressing human Nogo-A...
  20. pmc Toll-like receptor 4 is required for α-synuclein dependent activation of microglia and astroglia
    Lisa Fellner
    Division of Neurobiology, Innsbruck Medical University, Austria
    Glia 61:349-60. 2013
    ..Our data provide novel insights into the mechanisms of α-synuclein-induced microglial and astroglial activation which may have an impact on understanding the pathogenesis of ASP...
  21. ncbi request reprint Plasma levels of soluble adhesion molecules sPECAM-1, sP-selectin and sE-selectin are associated with relapsing-remitting disease course of multiple sclerosis
    Bettina Kuenz
    Clinical Department of Neurology, Innsbruck Medical University, Anichstrasse 35, A 6020 Innsbruck, Austria
    J Neuroimmunol 167:143-9. 2005
    ..These findings indicate that sPECAM-1, sP-selectin and sE-selectin might be implemented as paraclinical markers of disease activity in MS with restriction to the clinical course of the disease...
  22. pmc Mesenchymal stem cells in a transgenic mouse model of multiple system atrophy: immunomodulation and neuroprotection
    Sylvia Stemberger
    Divison of Clinical Neurobiology, Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    PLoS ONE 6:e19808. 2011
    ..In this study we investigated the efficacy of intravenously applied MSCs in terms of behavioural improvement, neuroprotection and modulation of neuroinflammation in the (PLP)-αsynuclein (αSYN) MSA model...
  23. ncbi request reprint Antibodies as biological markers for pathophysiological processes in MS
    Markus Reindl
    Clinical Department of Neurology, Innsbruck Medical University, Anichstrasse 35, A 6020 Innsbruck, Austria
    J Neuroimmunol 180:50-62. 2006
    ..We believe that antibodies serving as biomarkers will help to establish a differential therapeutic concept in MS, which will allow to treat individuals selectively according to their pathogenetic subtype and disease status...
  24. doi request reprint Impact of human myelin on the maturation and function of human monocyte-derived dendritic cells
    Viktoria Gredler
    Clinical Department of Neurology, Innsbruck Medical University, Austria
    Clin Immunol 134:296-304. 2010
    ..We hypothesize that myelin influences DC activation and plays a pivotal role in balancing immunity and tolerance...
  25. pmc Oxidative stress in transgenic mice with oligodendroglial alpha-synuclein overexpression replicates the characteristic neuropathology of multiple system atrophy
    Nadia Stefanova
    Clinical Department of Neurology, Innsbruck Medical University, Anichstrasse 35 A 6020, Innsbruck, Austria
    Am J Pathol 166:869-76. 2005
    ..Our results indicate that combined mitochondrial inhibition and overexpression of oligodendroglial alpha-SYN generates a novel model of MSA that may be useful for evaluating both pathogenesis and treatment strategies...
  26. doi request reprint Correlation of frataxin content in blood and skeletal muscle endorses frataxin as a biomarker in Friedreich ataxia
    Wolfgang Nachbauer
    Department of Neurology, Medical University Innsbruck, Innsbruck, Austria
    Mov Disord 26:1935-8. 2011
    ..Assays to quantitatively measure frataxin in peripheral blood have been established. To determine the validity of frataxin as a biomarker for clinical trials, we assessed frataxin in clinically affected tissue...
  27. ncbi request reprint Multiple sclerosis - established and novel therapeutic approaches
    Rainer Ehling
    Clinical Department of Neurology, Innsbruck Medical University, Austria
    Cent Nerv Syst Agents Med Chem 10:3-15. 2010
    ..This will pave the way for an optimized treatment approach, which will likely need both to target inflammation and to focus on promotion of neuroprotection and repair...
  28. ncbi request reprint Antimyelin antibodies as a predictor of clinically definite multiple sclerosis after a first demyelinating event
    Thomas Berger
    Department of Neurology, University of Innsbruck, Innsbruck, Austria
    N Engl J Med 349:139-45. 2003
    ....
  29. ncbi request reprint Intrathecal anti-alphaB-crystallin IgG antibody responses: potential inflammatory markers in Guillain-Barré syndrome
    Julia Wanschitz
    Clinical Department of Neurology, Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, Austria
    J Neurol 255:917-24. 2008
    ..To address the role of alphaBC in Guillain-Barré syndrome (GBS) we analyzed humoral responses against alphaBC in relation to clinical, electrophysiological and CSF features in GBS...
  30. ncbi request reprint Endovascular cooling and endothelial activation in hemorrhagic stroke patients
    Marlene Fischer
    Department of Neurology, Neurologic Intensive Care Unit, Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, Austria
    Neurocrit Care 17:224-30. 2012
    ..This analysis was designed to measure the endothelial markers Angiopoietin-1 (Ang-1) and -2 (Ang-2) in endovascularly based prophylactic normothermia versus conventional temperature management...
  31. pmc Antibodies to myelin oligodendrocyte glycoprotein in HIV-1 associated neurocognitive disorder: a cross-sectional cohort study
    Peter Lackner
    Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    J Neuroinflammation 7:79. 2010
    ..This cross-sectional cohort study explores the potential role of antibodies to myelin oligodendrocyte glycoprotein (MOG), a putative autoantigen in multiple sclerosis, in the pathogenesis of HAND...
  32. doi request reprint Natalizumab treatment reduces endothelial activity in MS patients
    Alban Millonig
    Department of Neurology, Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, Austria
    J Neuroimmunol 227:190-4. 2010
    ..Correspondingly Natalizumab diminished VLA-4 on leukocyte subsets. Our findings indicate that Natalizumab reduces transmigration not only by blocking VLA-4 but also by down-regulating VCAM-1...
  33. ncbi request reprint Epitope specificity of neutralizing antibodies against IFN-beta
    Claudia Gneiss
    Department of Neurology, University of Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria
    J Interferon Cytokine Res 24:283-90. 2004
    ..Our results indicate a qualitative and quantitative difference between NAb and NNAb, with special emphasis on the recognition of different epitopes...
  34. ncbi request reprint Antibody response to myelin oligodendrocyte glycoprotein and myelin basic protein depend on familial background and are partially associated with human leukocyte antigen alleles in multiplex families and sporadic multiple sclerosis
    Andreas Lutterotti
    Department of Neurology, University of Innsbruck, Anichstrasse 35, A 6020, Innsbruck, Austria
    J Neuroimmunol 131:201-7. 2002
    ..We conclude that antibody responses to MOG and MBP depend on familial background. Moreover, the humoral immune reactivity against MOG is partially under control of certain HLA class II alleles...
  35. ncbi request reprint Loss of dopaminergic responsiveness in a double lesion rat model of the Parkinson variant of multiple system atrophy
    Martin Köllensperger
    Clinical Department of Neurology, Innsbruck Medical University, Austria
    Mov Disord 22:353-8. 2007
    ..593; P = 0.01) in the stepping test. These findings contribute further to the behavioral characterization of the double lesion rat model of MSA, improving its value in the evaluation of future neurorestorative strategies...
  36. pmc Glatiramer acetate reduces the risk for experimental cerebral malaria: a pilot study
    Peter Lackner
    Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    Malar J 8:36. 2009
    ....
  37. pmc Toll-like receptor 4 promotes α-synuclein clearance and survival of nigral dopaminergic neurons
    Nadia Stefanova
    Division of Clinical Neurobiology, Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    Am J Pathol 179:954-63. 2011
    ..The study supports TLR4 signaling as innate neuroprotective mechanism acting through clearance of α-synuclein...
  38. pmc Nogo receptor is involved in the adhesion of dendritic cells to myelin
    Claire L McDonald
    Clinical Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    J Neuroinflammation 8:113. 2011
    ..The exact mechanisms of interaction of immune cells with CNS myelin are, however, poorly understood...
  39. pmc Fibrinogen is not elevated in the cerebrospinal fluid of patients with multiple sclerosis
    Rainer Ehling
    Clinical Department of Neurology, Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, Austria
    Fluids Barriers CNS 8:25. 2011
    ..abstract:..
  40. doi request reprint Cellular aging reflected by leukocyte telomere length predicts advanced atherosclerosis and cardiovascular disease risk
    Peter Willeit
    Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    Arterioscler Thromb Vasc Biol 30:1649-56. 2010
    ..To determine the association between leukocyte telomere length (TL) and atherosclerosis and its clinical sequelae stroke and myocardial infarction...
  41. doi request reprint Influence of interferon-beta therapy switching on neutralizing antibody titres: results from the Austrian Switch Study
    Claudia Gneiss
    Clinical Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    Mult Scler 15:1481-8. 2009
    ..Baseline and final neutralizing antibody titres correlated significantly. In conclusion, neither switching nor continuous therapy with any subcutaneous interferon-beta preparation significantly changed neutralizing antibody titres...
  42. pmc The generation of NGF-secreting primary rat monocytes: a comparison of different transfer methods
    Lindsay A Hohsfield
    Department of Psychiatry, Laboratory of Psychiatry and Experimental Alzheimer s Research, Innsbruck Medical University, Innsbruck, Austria
    J Immunol Methods 391:112-24. 2013
    ..This study also provides a basis for further development of primary monocytes as therapeutic delivery vehicles to the diseased AD brain...
  43. ncbi request reprint Animal models of multiple system atrophy
    Nadia Stefanova
    Clinical Department of Neurology, Innsbruck Medical University, 6020 Innsbruck, Austria
    Trends Neurosci 28:501-6. 2005
    ..Here, the currently available MSA animal models will be reviewed and leads for future research will be identified...
  44. ncbi request reprint Biological markers for multiple sclerosis
    Andreas Lutterotti
    Clinical Department of Neurology, Innsbruck Medical University, Anichstrasse 35, A 6020 Innsbruck, Austria
    Curr Med Chem 14:1956-65. 2007
    ....
  45. ncbi request reprint Tumor necrosis factor-alpha-induced cell death in U373 cells overexpressing alpha-synuclein
    Nadia Stefanova
    Department of Neurology, University of Innsbruck, Innsbruck, Austria
    J Neurosci Res 73:334-40. 2003
    ..We conclude that alpha-synuclein overexpression significantly increases the vulnerability of U373 cells to apoptosis through TNF-alpha-mediated pathways...
  46. doi request reprint Anti-myelin oligodendrocyte glycoprotein antibodies in pediatric patients with optic neuritis
    Kevin Rostasy
    Division of Pediatric Neurology and Inherited Metabolic Disorders, Department of Pediatrics IV, Innsbruck Medical University, Anichstrasse 35, A 6020 Innsbruck, Austria
    Arch Neurol 69:752-6. 2012
    ..To study the humoral immune response directed at myelin oligodendrocyte glycoprotein (MOG)in pediatric patients with isolated and recurrent optic neuritis(ON)...
  47. pmc Murine malaria is associated with significant hearing impairment
    Joachim Schmutzhard
    Department of Otorhinolaryngology, Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck Austria
    Malar J 9:159. 2010
    ..Developmental, cognitive and language disorders have been observed in children, surviving cerebral malaria. This prospective study aims to evaluate whether malaria influences hearing in mice...
  48. ncbi request reprint Matrix metalloproteinases and their tissue inhibitors (TIMPs) in Plasmodium falciparum malaria: serum levels of TIMP-1 are associated with disease severity
    Anelia Dietmann
    Clinical Department of Neurology, Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, Austria
    J Infect Dis 197:1614-20. 2008
    ..The key inhibitors of MMPs are the tissue inhibitors of metalloproteinases (TIMPs)...
  49. doi request reprint Effects of erythropoietin on frataxin levels and mitochondrial function in Friedreich ataxia--a dose-response trial
    Wolfgang Nachbauer
    Department of Neurology, Medical University Innsbruck, Anichstrasse 35, Innsbruck, Austria
    Cerebellum 10:763-9. 2011
    ..To detect frataxin-derived neuroprotective effects resulting in clinically relevant improvement, well-designed studies with extended time frame are required...
  50. pmc Biomarkers in multiple sclerosis: role of antibodies
    Thomas Berger
    Clinical Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    Dis Markers 22:207-12. 2006
    ..The present review summarizes the presentation on the potential role of antibodies as biomarkers for diagnosis, disease activity, classification and prediction of clinical courses in multiple sclerosis...
  51. ncbi request reprint Multiple sclerosis: disease biomarkers as indicated by pathophysiology
    Thomas Berger
    Clinical Department of Neurology, Innsbruck Medical University, Anichstrasse 35, A 6020 Innsbruck, Austria
    J Neurol Sci 259:21-6. 2007
    ..Antibodies (and other molecules) serving as biomarkers will help to establish a differential therapeutic concept in MS, which should allow to treat individuals selectively according to their pathogenetic subtype and disease status...
  52. doi request reprint Axl and growth arrest-specific gene 6 are frequently overexpressed in human gliomas and predict poor prognosis in patients with glioblastoma multiforme
    Markus Hutterer
    Clinical Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    Clin Cancer Res 14:130-8. 2008
    ..However, the effect of Axl and its ligand growth arrest--specific gene 6 (Gas6) in human gliomas is still unknown...
  53. ncbi request reprint Role of autoantibodies in acquired inflammatory demyelinating diseases of the central nervous system in children
    Kevin Rostasy
    Division of Pediatric Neurology, Department of Pediatrics I, Innsbruck Medical University, Innsbruck, Austria
    Neuropediatrics 44:297-301. 2013
    ..This review aims to give an overview of the role of autoantibodies in inflammatory demyelinating pediatric diseases, with a focus on antibodies to AQP4 and MOG. ..
  54. ncbi request reprint Brain capillary endothelial cells proliferate in response to NGF, express NGF receptors and secrete NGF after inflammation
    Karma V Moser
    Laboratory of Psychiatry, Univ Clinic of Psychiatry, University Innsbruck, Anichstr 35, A 6020 Innsbruck, Austria
    Brain Res 1017:53-60. 2004
    ..In summary, NGF shows proliferative activity in BCEC, and NGF is secreted after inflammation. Therefore, the NGF pathway can modulate BCEC and may influence blood-brain barrier functions...
  55. doi request reprint Naturally occurring α-synuclein autoantibody levels are lower in patients with Parkinson disease
    Daniela Besong-Agbo
    Department of Neurology, Philipps University Marburg, Marburg
    Neurology 80:169-75. 2013
    ..Recently, naturally occurring autoantibodies against α-Syn (α-Syn-nAbs) have been detected in the serum of patients with PD. They represent a putative diagnostic marker for PD...
  56. ncbi request reprint Neuropathological and behavioral changes induced by various treatment paradigms with MPTP and 3-nitropropionic acid in mice: towards a model of striatonigral degeneration (multiple system atrophy)
    Nadia Stefanova
    Department of Neurology, University Hospital of Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria
    Acta Neuropathol 106:157-66. 2003
    ..This suggests that complex integrative mechanisms are likely to regulate the vulnerability of the striatum and SNc to cell death in SND/MSA-P...
  57. doi request reprint Influences on the reduction of relative telomere length over 10 years in the population-based Bruneck Study: introduction of a well-controlled high-throughput assay
    Silvia Ehrlenbach
    Division of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Innsbruck Medical University, Innsbruck, Austria
    Int J Epidemiol 38:1725-34. 2009
    ..Short telomeres are linked to age-associated diseases and cancer. Our aim was to determine the decrease rate of relative telomere length (RTL) over 10 years and whether this rate was influenced by age, sex and smoking behaviour...
  58. ncbi request reprint Time course of coagulation parameters, cytokines and adhesion molecules in Plasmodium falciparum malaria
    Alexander Vogetseder
    University Hospital Innsbruck, Department of Neurology and Central Laboratories, Innsbruck, Austria
    Trop Med Int Health 9:767-73. 2004
    ..IL-6 and IL-10 decreased significantly over 5 days during schizontocidal therapy. Our data show an impairment of the coagulation system which correlates with pro-inflammatory cytokines and therefore with the severity of the disease...
  59. ncbi request reprint Glial cell line-derived neurotrophic factor enhances survival of GM-CSF dependent rat GMIR1-microglial cells
    Kayvon Salimi
    Laboratory of Psychiatry, Department of Psychiatry, University of Innsbruck, Anichstrasse 35, Austria
    Neurosci Res 43:221-9. 2002
    ..Inhibition of cAMP/cGMP dependent protein kinase enhanced the GDNF-induced GMIR1 cell number. The results suggest that GDNF has synergistic survival promoting effects on microglia potentially via autocrine mechanisms...
  60. ncbi request reprint Toll-like receptor 4 polymorphisms and atherogenesis
    Stefan Kiechl
    Department of Neurology, University Clinic, Innsbruck, Austria
    N Engl J Med 347:185-92. 2002
    ..We determined whether recently discovered genetic variants of toll-like receptor 4 (TLR4) that confer differences in the inflammatory response elicited by bacterial lipopolysaccharide are related to the development of atherosclerosis...
  61. ncbi request reprint Targeting the Nogo receptor complex in diseases of the central nervous system
    C L McDonald
    Clinical Department of Neurology, Innsbruck Medical University, Austria
    Curr Med Chem 18:234-44. 2011
    ....