Werner H Poewe

Summary

Affiliation: Innsbruck Medical University
Country: Austria

Publications

  1. pmc Role and clinical utility of pramipexole extended release in the treatment of early Parkinson's disease
    Eva Maria Hametner
    Department of Neurology, Innsbruck Medical University, Austria
    Clin Interv Aging 7:83-8. 2012
  2. pmc An antibody microarray analysis of serum cytokines in neurodegenerative Parkinsonian syndromes
    Philipp Mahlknecht
    Clinical Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    Proteome Sci 10:71. 2012
  3. doi request reprint Emerging therapies for Parkinson's disease
    Werner Poewe
    University Klinik für Neurologie, University of Innsbruck, Innsbruck, Austria
    Curr Opin Neurol 25:448-59. 2012
  4. pmc Treatment of moderate to severe restless legs syndrome: 2-year safety and efficacy of rotigotine transdermal patch
    Birgit Hogl
    Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    BMC Neurol 10:86. 2010
  5. doi request reprint When a Parkinson's disease patient starts to hallucinate
    Werner Poewe
    Department of Neurology, Medical University of Innsbruck, Anichstrasse 35, A 6020 Innsbruck, Austria
    Pract Neurol 8:238-41. 2008
  6. doi request reprint Extended-release pramipexole in early Parkinson disease: a 33-week randomized controlled trial
    W Poewe
    Innsbruck Medical University, Innsbruck, Austria
    Neurology 77:759-66. 2011
  7. doi request reprint Non-motor symptoms in Parkinson's disease
    W Poewe
    Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria
    Eur J Neurol 15:14-20. 2008
  8. ncbi request reprint Efficacy of pramipexole and transdermal rotigotine in advanced Parkinson's disease: a double-blind, double-dummy, randomised controlled trial
    Werner H Poewe
    Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    Lancet Neurol 6:513-20. 2007
  9. doi request reprint Clinical measures of progression in Parkinson's disease
    Werner Poewe
    Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    Mov Disord 24:S671-6. 2009
  10. pmc Oxidative stress in transgenic mice with oligodendroglial alpha-synuclein overexpression replicates the characteristic neuropathology of multiple system atrophy
    Nadia Stefanova
    Clinical Department of Neurology, Innsbruck Medical University, Anichstrasse 35 A 6020, Innsbruck, Austria
    Am J Pathol 166:869-76. 2005

Detail Information

Publications70

  1. pmc Role and clinical utility of pramipexole extended release in the treatment of early Parkinson's disease
    Eva Maria Hametner
    Department of Neurology, Innsbruck Medical University, Austria
    Clin Interv Aging 7:83-8. 2012
    ....
  2. pmc An antibody microarray analysis of serum cytokines in neurodegenerative Parkinsonian syndromes
    Philipp Mahlknecht
    Clinical Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    Proteome Sci 10:71. 2012
    ..abstract:..
  3. doi request reprint Emerging therapies for Parkinson's disease
    Werner Poewe
    University Klinik für Neurologie, University of Innsbruck, Innsbruck, Austria
    Curr Opin Neurol 25:448-59. 2012
    ..The experimental therapeutics of Parkinson's disease are reviewed, highlighting the current pipeline of emerging therapeutic approaches...
  4. pmc Treatment of moderate to severe restless legs syndrome: 2-year safety and efficacy of rotigotine transdermal patch
    Birgit Hogl
    Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    BMC Neurol 10:86. 2010
    ..This study reports the 2-year follow-up safety and efficacy data of an ongoing open-label multicenter extension study (NCT00498186) of transdermal rotigotine in patients with moderate to severe restless legs syndrome (RLS)...
  5. doi request reprint When a Parkinson's disease patient starts to hallucinate
    Werner Poewe
    Department of Neurology, Medical University of Innsbruck, Anichstrasse 35, A 6020 Innsbruck, Austria
    Pract Neurol 8:238-41. 2008
    ..Visual hallucinations in Parkinson's disease patients with dementia can also be improved by treatment with the cholinesterase inhibitor rivastigmine...
  6. doi request reprint Extended-release pramipexole in early Parkinson disease: a 33-week randomized controlled trial
    W Poewe
    Innsbruck Medical University, Innsbruck, Austria
    Neurology 77:759-66. 2011
    ....
  7. doi request reprint Non-motor symptoms in Parkinson's disease
    W Poewe
    Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria
    Eur J Neurol 15:14-20. 2008
    ..This review article provides an overview of the clinical spectrum of non-motor symptoms in PD together with a brief review of treatment options...
  8. ncbi request reprint Efficacy of pramipexole and transdermal rotigotine in advanced Parkinson's disease: a double-blind, double-dummy, randomised controlled trial
    Werner H Poewe
    Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    Lancet Neurol 6:513-20. 2007
    ....
  9. doi request reprint Clinical measures of progression in Parkinson's disease
    Werner Poewe
    Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    Mov Disord 24:S671-6. 2009
    ....
  10. pmc Oxidative stress in transgenic mice with oligodendroglial alpha-synuclein overexpression replicates the characteristic neuropathology of multiple system atrophy
    Nadia Stefanova
    Clinical Department of Neurology, Innsbruck Medical University, Anichstrasse 35 A 6020, Innsbruck, Austria
    Am J Pathol 166:869-76. 2005
    ..Our results indicate that combined mitochondrial inhibition and overexpression of oligodendroglial alpha-SYN generates a novel model of MSA that may be useful for evaluating both pathogenesis and treatment strategies...
  11. ncbi request reprint Failure of caspase inhibition in the double-lesion rat model of striatonigral degeneration (multiple system atrophy)
    Laura Mantoan
    Clinical Department of Neurology, Innsbruck Medical University, Anichstrasse 35, 6020, Innsbruck, Austria
    Acta Neuropathol 109:191-7. 2005
    ....
  12. ncbi request reprint Microglial activation mediates neurodegeneration related to oligodendroglial alpha-synucleinopathy: implications for multiple system atrophy
    Nadia Stefanova
    Clinical Neurobiology Unit, Neurodegeneration Research Laboratory, Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    Mov Disord 22:2196-203. 2007
    ....
  13. ncbi request reprint High dose levodopa therapy is not toxic in multiple system atrophy: experimental evidence
    Nadia Stefanova
    Clinical Neurobiology Unit, Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    Mov Disord 22:969-73. 2007
    ..These findings support the idea that high dose levodopa therapy in MSA is not detrimental to the underlying neuropathological process...
  14. doi request reprint The severity range of restless legs syndrome (RLS) and augmentation in a prospective patient cohort: association with ferritin levels
    Birgit Frauscher
    Department of Neurology, Innsbruck Medical University, Anichstrasse 35, A 6020 Innsbruck, Austria
    Sleep Med 10:611-5. 2009
    ..The aim of the study was to prospectively examine all patients with a diagnosis of RLS consulting a sleep disorders clinic and to assess RLS severity and augmentation and their associations, including ferritin levels...
  15. ncbi request reprint Psychosis in Parkinson's disease
    Werner Poewe
    Department of Neurology, University of Innsbruck, Innsbruck, Austria
    Mov Disord 18:S80-7. 2003
    ..Cholinesterase inhibitors may prove an additional option in psychotic PD patients with dementia...
  16. ncbi request reprint Evidence for dopaminergic re-innervation by embryonic allografts in an optimized rat model of the Parkinsonian variant of multiple system atrophy
    Zoe Puschban
    Experimental Neurodegeneration Laboratory, Department of Neurology, University Hospital Innsbruck, Anichstrasse 35, A 6020 Innsbruck, Austria
    Brain Res Bull 68:54-8. 2005
    ..e. early stage disease with limited striatal dysfunction...
  17. ncbi request reprint The relation between abnormal behaviors and REM sleep microstructure in patients with REM sleep behavior disorder
    Birgit Frauscher
    Innsbruck Medical University, Department of Neurology, Anichstrasse 35, A 6020 Innsbruck, Austria
    Sleep Med 10:174-81. 2009
    ..To investigate the temporal relation between rapid eye movement (REM) sleep microstructure (REMs, EMG activity) and motor events in REM sleep behavior disorder (RBD)...
  18. doi request reprint Rasagiline is neuroprotective in a transgenic model of multiple system atrophy
    Nadia Stefanova
    Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    Exp Neurol 210:421-7. 2008
    ..5 mg/kg rasagiline. The results of the study indicate that rasagiline confers neuroprotection in a transgenic mouse model of MSA and may therefore be considered a promising disease-modifying candidate for human MSA...
  19. ncbi request reprint Disturbance of rapid eye movement sleep in spinocerebellar ataxia type 2
    Sylvia M Boesch
    Clinical Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    Mov Disord 21:1751-4. 2006
    ..Abnormal motor control during sleep with periodic leg movements and REM sleep without atonia occurs frequently in SCA2. This finding may reflect a dysfunction of dopaminergic and/or brainstem and cerebellar outflow pathways...
  20. ncbi request reprint Abnormal responses to repetitive transcranial magnetic stimulation in multiple system atrophy
    Wolfgang N Löscher
    Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    Mov Disord 22:174-8. 2007
    ..We suggest that these abnormalities reflect the motor cortex pathology found in MSA-P...
  21. ncbi request reprint Loss of dopaminergic responsiveness in a double lesion rat model of the Parkinson variant of multiple system atrophy
    Martin Köllensperger
    Clinical Department of Neurology, Innsbruck Medical University, Austria
    Mov Disord 22:353-8. 2007
    ..593; P = 0.01) in the stepping test. These findings contribute further to the behavioral characterization of the double lesion rat model of MSA, improving its value in the evaluation of future neurorestorative strategies...
  22. ncbi request reprint Neuropathological and behavioral changes induced by various treatment paradigms with MPTP and 3-nitropropionic acid in mice: towards a model of striatonigral degeneration (multiple system atrophy)
    Nadia Stefanova
    Department of Neurology, University Hospital of Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria
    Acta Neuropathol 106:157-66. 2003
    ..This suggests that complex integrative mechanisms are likely to regulate the vulnerability of the striatum and SNc to cell death in SND/MSA-P...
  23. doi request reprint White and gray matter abnormalities in idiopathic rapid eye movement sleep behavior disorder: a diffusion-tensor imaging and voxel-based morphometry study
    Christoph Scherfler
    Department of Neurology, Innsbruck Medical University, Austria
    Ann Neurol 69:400-7. 2011
    ....
  24. doi request reprint Neurological effects of recombinant human erythropoietin in Friedreich's ataxia: a clinical pilot trial
    Sylvia Boesch
    Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    Mov Disord 23:1940-4. 2008
    ..Safety monitoring with regular blood cell counts and parameters of iron metabolism is a potential limitation of this approach...
  25. doi request reprint Multiple system atrophy: a primary oligodendrogliopathy
    Gregor K Wenning
    Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    Ann Neurol 64:239-46. 2008
    ..Although these syndromes vary in their respective cause of oligodendrogliopathy, they have in common myelin disruption that is often followed by axonal dysfunction...
  26. pmc A descriptive analysis of neck myoclonus during routine polysomnography
    Birgit Frauscher
    Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    Sleep 33:1091-6. 2010
    ..This study assesses the occurrence, frequency, and characteristics of neck myoclonus in REM sleep in a prospective sleep disorder cohort, and investigates clinical correlates and associations with medication...
  27. ncbi request reprint Akathisia, restless legs and periodic limb movements in sleep in Parkinson's disease
    Werner Poewe
    Department of Neurology, University of Innsbruck, Innsbruck, Austria
    Neurology 63:S12-6. 2004
    ..Long-term prospective studies of RLS cohorts will clarify whether or not RLS is associated with an increased risk for development of PD...
  28. doi request reprint Striatal transplantation for multiple system atrophy--are grafts affected by alpha-synucleinopathy?
    Nadia Stefanova
    Department of Clinical Neurobiology, Innsbruck Medical University, Innsbruck, Austria
    Exp Neurol 219:368-71. 2009
    ..Our data suggest that the presence of MSA-like alpha-synuclein oligodendrogliopathy and related to it pro-inflammatory microenvironment may compromise the connectivity and neurorestorative outcome of striatal grafts...
  29. doi request reprint Restless legs syndrome in Parkinson's disease
    Cecilia M Peralta
    Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    Mov Disord 24:2076-80. 2009
    ..7 years). The majority (n = 17, 61%) who scored positive for RLS reported that the urge to move the legs and unpleasant sensations were associated with wearing off, raising the possibility of RLS mimics in fluctuating patients with PD...
  30. pmc Targeted overexpression of human alpha-synuclein in oligodendroglia induces lesions linked to MSA-like progressive autonomic failure
    Sylvia Stemberger
    Division of Clinical Neurobiology, Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    Exp Neurol 224:459-64. 2010
    ....
  31. doi request reprint Treatments for Parkinson disease--past achievements and current clinical needs
    Werner Poewe
    Department of Neurology, Medical University Innsbruck, Innsbruck, Austria
    Neurology 72:S65-73. 2009
    ..As understanding of preclinical markers for PD develops, there is new hope for neuropreventive strategies to target "at risk" populations before clinical onset of disease...
  32. doi request reprint A novel computer-assisted image analysis of [123I]β-CIT SPECT images improves the diagnostic accuracy of parkinsonian disorders
    Georg Goebel
    Department of Medical Statistics, Informatics and Health Economics, Innsbruck Medical University, Schöpfstrasse 41 2, A 6020, Innsbruck, Austria
    Eur J Nucl Med Mol Imaging 38:702-10. 2011
    ....
  33. ncbi request reprint Voxel-wise analysis of [123I]beta-CIT SPECT differentiates the Parkinson variant of multiple system atrophy from idiopathic Parkinson's disease
    Christoph Scherfler
    Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    Brain 128:1605-12. 2005
    ..We suggest that the quantification of midbrain DAT signal should be included in the routine clinical analysis of [123I]beta-CIT SPECT in patients with uncertain parkinsonism...
  34. doi request reprint Striatal transplantation in a rodent model of multiple system atrophy: effects on L-Dopa response
    Martin Köllensperger
    Section for Clinical Neurobiology, Innsbruck Medical University, Innsbruck, Austria
    J Neurosci Res 87:1679-85. 2009
    ..Therefore, striatal transplantation should be further defined preclinically as a possible therapeutic option for patients with MSA-P and a failing L-Dopa response...
  35. doi request reprint Scales to assess sleep impairment in Parkinson's disease: critique and recommendations
    Birgit Hogl
    Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    Mov Disord 25:2704-16. 2010
    ..The task force does not recommend the development of new scales, but emphasizes the need for educational efforts to train physicians in sleep interview techniques and polysomnography...
  36. ncbi request reprint Friedreich's ataxia: clinical pilot trial with recombinant human erythropoietin
    Sylvia Boesch
    Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    Ann Neurol 62:521-4. 2007
    ..Treatment with recombinant human erythropoietin showed a persistent and significant increase in frataxin levels after 8 weeks (p < 0.01). All patients showed a reduction of oxidative stress markers...
  37. pmc Quantification of electromyographic activity during REM sleep in multiple muscles in REM sleep behavior disorder
    Birgit Frauscher
    Innsbruck Medical University, Department of Neurology, Innsbruck, Austria
    Sleep 31:724-31. 2008
    ....
  38. ncbi request reprint Progression of parkinsonism in multiple system atrophy
    Klaus Seppi
    Department of Neurology, University Hospital, Innsbruck, Austria
    J Neurol 252:91-6. 2005
    ..However, it may also be subject to considerable variation. Prospective natural history studies using validated rating scales are required to accurately determine the progression of parkinsonism in MSA...
  39. ncbi request reprint Treatment of dementia with Lewy bodies and Parkinson's disease dementia
    Werner Poewe
    Department of Neurology, Medical University of Innsbruck, Austria
    Mov Disord 20:S77-82. 2005
    ..Clozapine and quetiapine are the drugs most commonly used and, contrary to classic neuroleptics, risperidone or olanzapine do not seem to cause severe side effects according to published data...
  40. ncbi request reprint Periodic limb movement counting in polysomnography: effects of amplitude
    Viola Gschliesser
    Department of Neurology, Medical University of Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria
    Sleep Med 7:249-54. 2006
    ..This study investigates the relationship between periodic limb movement (PLM) counts obtained with standard scoring criteria and PLM counts scored without amplitude criterion (AC)...
  41. ncbi request reprint Increased daytime sleepiness in Parkinson's disease: a questionnaire survey
    Birgit Hogl
    Department of Neurology, University of Innsbruck, Anichstrasse 35, A 6020 Innsbruck, Austria
    Mov Disord 18:319-23. 2003
    ..Increased daytime sleepiness is more frequent in patients with PD than in elderly controls. Similar to controls, increased daytime sleepiness in PD patients is correlated with heavy snoring...
  42. ncbi request reprint Role of dopamine transporter imaging in investigation of parkinsonian syndromes in routine clinical practice
    Werner Poewe
    Department of Neurology, University Hospital, Innsbruck, Austria
    Mov Disord 18:S16-21. 2003
    ..DAT-SPECT facilitates differential diagnosis of the different parkinsonian syndromes that cannot be reliably separated on clinical grounds and it can thus provide valuable diagnostic information in early disease...
  43. ncbi request reprint The role of COMT inhibition in the treatment of Parkinson's disease
    Werner Poewe
    Department of Neurology, University of Innsbruck, Innsbruck, Austria
    Neurology 62:S31-8. 2004
    ..Studies to determine if administering levodopa in combination with entacapone will delay the development of dyskinesia and motor fluctuations are eagerly awaited...
  44. ncbi request reprint Evaluation of [123I]IBZM pinhole SPECT for the detection of striatal dopamine D2 receptor availability in rats
    Christoph Scherfler
    Clinical Department of Neurology, Innsbruck Medical University, 6020 Innsbruck, Austria
    Neuroimage 24:822-31. 2005
    ..SPECT-MRI-based estimation of regional [123I]IBZM uptake provides a cost effective and widely available in vivo imaging technique for assessing striatal integrity in animal studies...
  45. ncbi request reprint Development and validation of the Unified Multiple System Atrophy Rating Scale (UMSARS)
    Gregor K Wenning
    Department of Neurology, University of Innsbruck, Austria
    Mov Disord 19:1391-402. 2004
    ..Based on our findings, the UMSARS appears to be a multidimensional, reliable, and valid scale for semiquantitative clinical assessments of MSA patients...
  46. doi request reprint REM sleep behavior disorder in 703 sleep-disorder patients: the importance of eliciting a comprehensive sleep history
    Birgit Frauscher
    Innsbruck Medical University, Department of Neurology, Anichstrasse 35, A 6020 Innsbruck, Austria
    Sleep Med 11:167-71. 2010
    ..Moreover, we investigated referral diagnoses of patients subsequently diagnosed with RBD and assessed the frequency of incidental RBD...
  47. doi request reprint Long-term antidyskinetic efficacy of amantadine in Parkinson's disease
    Elisabeth Wolf
    Department of Neurology, Medical University Innsbruck, Innsbruck, Austria
    Mov Disord 25:1357-63. 2010
    ..2 (95% CI, 2.1-4.4) to follow-up 3.6 (95% CI, 2.3-4.8) in patients staying on amantadine. These findings argue for long-term antidyskinetic efficacy of amantadine in PD patients with LID's...
  48. ncbi request reprint Comparison of diffusion-weighted imaging and [123I]IBZM-SPECT for the differentiation of patients with the Parkinson variant of multiple system atrophy from those with Parkinson's disease
    Klaus Seppi
    Department of Neurology, University of Innsbruck, Innsbruck, Austria
    Mov Disord 19:1438-45. 2004
    ..Striatal rADCs had a significant higher overall predictive accuracy than D2R binding with IBZM. In summary, our data suggest that DWI may be more accurate compared to IBZM-SPECT in the differential diagnosis of MSA-P versus PD...
  49. ncbi request reprint Failure of neuronal protection by inhibition of glial activation in a rat model of striatonigral degeneration
    Nadia Stefanova
    Neurodegeneration Research Laboratory, Innsbruck MSA Study Group, Clinical Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    J Neurosci Res 78:87-91. 2004
    ..We conclude that despite its astrocytic and microglial suppression, minocycline failed to attenuate lesion-induced neuronal damage in the SND rat model...
  50. ncbi request reprint Osteoprotegerin is a risk factor for progressive atherosclerosis and cardiovascular disease
    Stefan Kiechl
    Department of Neurology, University Clinic, Anichstrasse 35, A 6020 Innsbruck, Austria
    Circulation 109:2175-80. 2004
    ..Recent experimental research has implicated osteoprotegerin in atherogenesis, but epidemiological confirmation of this concept is sparse...
  51. ncbi request reprint Association of daytime sleepiness with COMT polymorphism in patients with parkinson disease: a pilot study
    Birgit Frauscher
    Innsbruck Medical University, Department of Neurology, Innsbruck, Austria
    Sleep 27:733-6. 2004
    ..To evaluate an association between catechol-O-methyltransferase (COMT) genotype and subjective daytime sleepiness in patients with Parkinson disease...
  52. ncbi request reprint Midbrain sonography in patients with essential tremor
    Heike Stockner
    Department of Neurology, Medical University Innsbruck, Austria
    Mov Disord 22:414-7. 2007
    ..These findings might correspond to an increased risk of ET patients to develop PD. Long-term follow-up will show if those with hyperechogenic SN develop PD, while these without will not...
  53. ncbi request reprint Auditory startle reaction is disinhibited in idiopathic restless legs syndrome
    Birgit Frauscher
    Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    Sleep 30:489-93. 2007
    ..Because the auditory startle reaction is abnormal in disorders with substantia nigra pathology, we hypothesized that auditory startle responses (ASRs) might also be altered in restless legs syndrome (RLS)...
  54. ncbi request reprint Diffusion weighted imaging best discriminates PD from MSA-P: A comparison with tilt table testing and heart MIBG scintigraphy
    Martin Köllensperger
    Clinical Department of Neurology, Innsbruck Medical University, Austria
    Mov Disord 22:1771-6. 2007
    ..6% vs. 100%, specificity 88.8% vs. 100%, and area under the curve 0.802 vs. 1.000. Our data suggest that DWI is superior to both tilt table testing and MIBG scintigraphy in the differential diagnosis of PD versus MSA-P...
  55. ncbi request reprint Restless legs syndrome and motor activity during sleep in spinocerebellar ataxia type 6
    Sylvia M Boesch
    Clinical Department of Neurology, Innsbruck Medical University, Anichstrasse 35, A 6020 Innsbruck, Austria
    Sleep Med 7:529-32. 2006
    ..We investigated the frequency of restless legs syndrome (RLS) and sleep disturbance in spinocerebellar ataxia type 6 (SCA6)...
  56. ncbi request reprint Progression of multiple system atrophy (MSA): a prospective natural history study by the European MSA Study Group (EMSA SG)
    Felix Geser
    Clinical Department of Neurology, Innsbruck Medical University, Austria
    Mov Disord 21:179-86. 2006
    ..Our data contribute to the ongoing validation process of UMSARS, and they facilitate the planning and implementation of future neuroprotective intervention trials...
  57. doi request reprint Red flags for multiple system atrophy
    Martin Köllensperger
    Section for Clinical Neurobiology, Department of Neurology, Innsbruck Medical University, Austria
    Mov Disord 23:1093-9. 2008
    ..9 (+/-7.0) months earlier than with the Consensus criteria alone. We propose a combination of two out of six red flag categories as additional diagnostic criteria for probable MSA-P...
  58. ncbi request reprint Prevalence of movement disorders in men and women aged 50-89 years (Bruneck Study cohort): a population-based study
    Gregor K Wenning
    Department of Neurology, Medical University Innsbruck, Innsbruck, Austria
    Lancet Neurol 4:815-20. 2005
    ..We sought to assess the prevalence of all common categories of movement disorders in a population, accounting for sex differences and age trends...
  59. ncbi request reprint Transcranial ultrasound shows nigral hypoechogenicity in restless legs syndrome
    Christoph Schmidauer
    Department of Neurology, Innsbruck Medical University, Austria
    Ann Neurol 58:630-4. 2005
    ..These findings lend further support to nigral iron deficiency as a pathogenetic factor in RLS...
  60. ncbi request reprint Voxel-based morphometry detects cortical atrophy in the Parkinson variant of multiple system atrophy
    Christian Brenneis
    Department of Neurology, University Hospital, Innsbruck, Austria
    Mov Disord 18:1132-8. 2003
    ..Further studies are required to determine clinical and/or subclinical correlates of cortical atrophy in MSA-P...
  61. ncbi request reprint Levodopa-induced sleepiness in the Parkinson variant of multiple system atrophy
    Klaus Seppi
    Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    Mov Disord 21:1281-3. 2006
    ..These findings suggest greater potential of levodopa to induce sleepiness in MSA compared with PD, which may be related to differences in basal ganglia and brainstem pathology between the two disorders...
  62. ncbi request reprint Progression of brain atrophy in multiple system atrophy. A longitudinal VBM study
    Christian Brenneis
    Clinical Department of Neurology, Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, Austria
    J Neurol 254:191-6. 2007
    ..The UPDRS-III score was not significantly correlated with any brain region. Our data suggest that cortical atrophy is prominent in MSA-P and early degeneration of the basal ganglia drives late onset cortical atrophy...
  63. ncbi request reprint Abnormalities of dopaminergic neurotransmission in SCA2: a combined 123I-betaCIT and 123I-IBZM SPECT study
    Sylvia M Boesch
    Department of Neurology, University of Innsbruck, Austria
    Mov Disord 19:1320-5. 2004
    ..Both slowness of limb movements as well as dystonia in the ataxic SCA2 phenotype may reflect dysfunction not only at cerebellar but also at basal ganglia level...
  64. ncbi request reprint Progression of putaminal degeneration in multiple system atrophy: a serial diffusion MR study
    Klaus Seppi
    Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    Neuroimage 31:240-5. 2006
    ....
  65. ncbi request reprint Long-term benefits of rivastigmine in dementia associated with Parkinson's disease: an active treatment extension study
    Werner Poewe
    Innsbruck Medical University, Innsbruck, Austria
    Mov Disord 21:456-61. 2006
    ..Long-term rivastigmine treatment appeared well tolerated and may provide sustained benefits in dementia associated with PD patients who remain on treatment for up to 48 weeks...
  66. doi request reprint Midbrain hyperechogenicity in idiopathic REM sleep behavior disorder
    Heike Stockner
    Department of Neurology, Medical University Innsbruck, Innsbruck 6020, Austria
    Mov Disord 24:1906-9. 2009
    ..The prospective follow-up of this iRBD cohort is needed to establish if those with midbrain hyperechogenicity will go on to develop clinically defined PD or not...
  67. ncbi request reprint Animal models of multiple system atrophy
    Nadia Stefanova
    Clinical Department of Neurology, Innsbruck Medical University, 6020 Innsbruck, Austria
    Trends Neurosci 28:501-6. 2005
    ..Here, the currently available MSA animal models will be reviewed and leads for future research will be identified...
  68. ncbi request reprint Computerized tremor analysis of valproate-induced tremor: a comparative study of controlled-release versus conventional valproate
    Martina Rinnerthaler
    Department of Neurology, Innsbruck Medical University, Austria
    Epilepsia 46:320-3. 2005
    ..conventional VPA). The aim of this study was quantitatively to assess tremor in epilepsy patients receiving VPA and to compare the effects of two VPA formulations (CR-VPA vs. VPA) on tremor severity...
  69. pmc Levodopa in the treatment of Parkinson's disease: an old drug still going strong
    Werner Poewe
    Department of Neurology, Medical University of Innsbruck, Austria
    Clin Interv Aging 5:229-38. 2010
    ..This review summarizes the available evidence regarding the use of LD to treat PD and will also address the issue of LD delivery as a critical factor for the drug's propensity to induce motor complications...
  70. ncbi request reprint Slower progression of Parkinson's disease with ropinirole versus levodopa: The REAL-PET study
    Alan L Whone
    Faculty of Medicine, Imperial College, Hammersmith Hospital, London, United Kingdom
    Ann Neurol 54:93-101. 2003
    ..1%; levodopa, -22.9%; 95% CI, 4.24-13.3), but the decrease was significantly lower with ropinirole compared with levodopa (p < 0.001). Ropinirole is associated with slower progression of PD than levodopa as assessed by (18)F-dopa PET...