S Perkhofer

Summary

Affiliation: Innsbruck Medical University
Country: Austria

Publications

  1. pmc Posaconazole enhances the activity of amphotericin B against Aspergillus hyphae in vitro
    Susanne Perkhofer
    Department of Hygiene, Microbiology and Social Medicine, Medical University Innsbruck, Fritz Pregl Str 3, A 6020 Innsbruck, Austria
    Antimicrob Agents Chemother 51:791-3. 2007
  2. ncbi In Vitro Susceptibility Testing in Fungi: What is its Role in Clinical Practice?
    Susanne Perkhofer
    Division of Hygiene and Medical Microbiology, Innsbruck Medical University, Fritz Pregl Strasse 3, 6020, Innsbruck, Austria
    Curr Infect Dis Rep 12:401-8. 2010
  3. doi Platelets enhance activity of antimycotic substances against non-Aspergillus fumigatus Aspergillus species in vitro
    Susanne Perkhofer
    Division of Hygiene and Medical Microbiology, Medical University Innsbruck, Innsbruck, Austria
    Med Mycol 49:157-66. 2011
  4. pmc Potential antifungal effects of human platelets against zygomycetes in vitro
    Susanne Perkhofer
    Department of Hygiene, Microbiology and Social Medicine, Division of Hygiene and Medical Microbiology, Innsbruck Medical University, Innsbruck, Austria
    J Infect Dis 200:1176-9. 2009
  5. doi Anidulafungin and voriconazole in invasive fungal disease: pharmacological data and their use in combination
    Susanne Perkhofer
    Innsbruck Medical University, Department of Hygiene, Microbiology and Social Medicine, Fritz Pregl Str 3, A 6020 Innsbruck, Austria
    Expert Opin Investig Drugs 18:1393-404. 2009
  6. pmc In vitro activity of Isavuconazole against Aspergillus species and zygomycetes according to the methodology of the European Committee on Antimicrobial Susceptibility Testing
    Susanne Perkhofer
    Department of Hygiene, Microbiology and Social Medicine, Division of Hygiene and Medical Microbiology, Innsbruck Medical University, Innsbruck, Austria
    Antimicrob Agents Chemother 53:1645-7. 2009
  7. pmc Human platelets attenuate Aspergillus species via granule-dependent mechanisms
    Susanne Perkhofer
    Department of Hygiene, Innsbruck Medical University, Austria
    J Infect Dis 198:1243-6. 2008
  8. pmc Posaconazole enhances the activity of amphotericin B against hyphae of zygomycetes in vitro
    Susanne Perkhofer
    Department of Hygiene, Microbiology and Social Medicine, Medical University Innsbruck, Fritz Pregl Str 3, A 6020 Innsbruck, Austria
    Antimicrob Agents Chemother 52:2636-8. 2008
  9. ncbi In vitro determination of phagocytosis and intracellular killing of Aspergillus species by mononuclear phagocytes
    Susanne Perkhofer
    Department of Hygiene, Microbiology and Social Medicine, Medical University Innsbruck, Fritz Pregl Strasse 3, 6020, Innsbruck, Austria
    Mycopathologia 163:303-7. 2007
  10. ncbi Influence of amphotericin B and amphotericin B colloidal dispersion on the functions of human phagocytes in defence against Aspergillus species
    S Perkhofer
    Department of Hygiene, Microbiology and Social Medicine, Medical University Innsbruck, Fritz Pregl Str 3, A 6020, Innsbruck, Austria
    Eur J Clin Microbiol Infect Dis 26:413-7. 2007

Detail Information

Publications21

  1. pmc Posaconazole enhances the activity of amphotericin B against Aspergillus hyphae in vitro
    Susanne Perkhofer
    Department of Hygiene, Microbiology and Social Medicine, Medical University Innsbruck, Fritz Pregl Str 3, A 6020 Innsbruck, Austria
    Antimicrob Agents Chemother 51:791-3. 2007
    ..POS-AMB had more synergistic activity against hyphae (75% of isolates) than VRZ-AMB (37%) and significantly more synergistic activity against hyphae than against conidia (12%)...
  2. ncbi In Vitro Susceptibility Testing in Fungi: What is its Role in Clinical Practice?
    Susanne Perkhofer
    Division of Hygiene and Medical Microbiology, Innsbruck Medical University, Fritz Pregl Strasse 3, 6020, Innsbruck, Austria
    Curr Infect Dis Rep 12:401-8. 2010
    ..This paper reviews the available methods for antifungal susceptibility testing of yeasts and filamentous fungi and the data regarding the clinical implications of in vitro testing...
  3. doi Platelets enhance activity of antimycotic substances against non-Aspergillus fumigatus Aspergillus species in vitro
    Susanne Perkhofer
    Division of Hygiene and Medical Microbiology, Medical University Innsbruck, Innsbruck, Austria
    Med Mycol 49:157-66. 2011
    ....
  4. pmc Potential antifungal effects of human platelets against zygomycetes in vitro
    Susanne Perkhofer
    Department of Hygiene, Microbiology and Social Medicine, Division of Hygiene and Medical Microbiology, Innsbruck Medical University, Innsbruck, Austria
    J Infect Dis 200:1176-9. 2009
    ..We found that platelets possess antifungal capacities against Zygomycetes based on granule dependent mechanisms and significantly reduce fungal growth and spread, both of which are of major importance in evolving invasive disease...
  5. doi Anidulafungin and voriconazole in invasive fungal disease: pharmacological data and their use in combination
    Susanne Perkhofer
    Innsbruck Medical University, Department of Hygiene, Microbiology and Social Medicine, Fritz Pregl Str 3, A 6020 Innsbruck, Austria
    Expert Opin Investig Drugs 18:1393-404. 2009
    ..In this review, the in vitro and in vivo activity of anidulafungin and voriconazole, both new antimycotic substances with a different mode of action, are analyzed...
  6. pmc In vitro activity of Isavuconazole against Aspergillus species and zygomycetes according to the methodology of the European Committee on Antimicrobial Susceptibility Testing
    Susanne Perkhofer
    Department of Hygiene, Microbiology and Social Medicine, Division of Hygiene and Medical Microbiology, Innsbruck Medical University, Innsbruck, Austria
    Antimicrob Agents Chemother 53:1645-7. 2009
    ..ISAV exhibited good antifungal activity against the tested isolates with the exception of Aspergillus niger and Mucorales. The in vitro activity of ISAV was comparable to that of voriconazole aside from Mucorales...
  7. pmc Human platelets attenuate Aspergillus species via granule-dependent mechanisms
    Susanne Perkhofer
    Department of Hygiene, Innsbruck Medical University, Austria
    J Infect Dis 198:1243-6. 2008
    ..05). A lack of antifungal effects was observed with the microfilament inhibitor cytochalasin D. Platelets attenuate the virulence of Aspergillus species in vitro on the basis of granule-dependent effects...
  8. pmc Posaconazole enhances the activity of amphotericin B against hyphae of zygomycetes in vitro
    Susanne Perkhofer
    Department of Hygiene, Microbiology and Social Medicine, Medical University Innsbruck, Fritz Pregl Str 3, A 6020 Innsbruck, Austria
    Antimicrob Agents Chemother 52:2636-8. 2008
    ..The combination of posaconazole with amphotericin B was found to be significantly more synergistic (40%) against hyphae (P < 0.05) than against conidia (10%). Antagonism was not observed...
  9. ncbi In vitro determination of phagocytosis and intracellular killing of Aspergillus species by mononuclear phagocytes
    Susanne Perkhofer
    Department of Hygiene, Microbiology and Social Medicine, Medical University Innsbruck, Fritz Pregl Strasse 3, 6020, Innsbruck, Austria
    Mycopathologia 163:303-7. 2007
    ..whereas phagocytosis was similar for all isolates tested in vitro. No differences were observed within environmental and clinical isolates...
  10. ncbi Influence of amphotericin B and amphotericin B colloidal dispersion on the functions of human phagocytes in defence against Aspergillus species
    S Perkhofer
    Department of Hygiene, Microbiology and Social Medicine, Medical University Innsbruck, Fritz Pregl Str 3, A 6020, Innsbruck, Austria
    Eur J Clin Microbiol Infect Dis 26:413-7. 2007
    ..fumigatus and A. terreus (p < 0.01).We demonstrate that amphotericin B or ABCD acts as a potent inhibitor of Aspergillus germination. By contrast, treatment of MDMs with these antimycotics diminished phagocytosis of conidia in vitro...
  11. pmc Susceptibility testing of anidulafungin and voriconazole alone and in combination against conidia and hyphae of Aspergillus spp. under hypoxic conditions
    Susanne Perkhofer
    Department of Hygiene, Microbiology and Social Medicine, Medical University of Innsbruck, Fritz Pregl Str 3, A 6020 Innsbruck, Austria
    Antimicrob Agents Chemother 52:1873-5. 2008
    ..Anidulafungin exhibited excellent activity against conidia and hyphae of Aspergillus spp. The visual reading of the MIC for anidulafungin was optimal under hypoxic conditions...
  12. pmc Interaction of 5-hydroxytryptamine (serotonin) against Aspergillus spp. in vitro
    Susanne Perkhofer
    Department of Hygiene, Microbiology and Social Medicine, Medical University Innsbruck, Austria
    Int J Antimicrob Agents 29:424-9. 2007
    ..05). 5-HT treatment for 4h resulted in a lag of re-growth (post-antifungal effect). In conclusion, our findings suggest that 5-HT affects hyphal growth and diminishes fungal cell membrane integrity...
  13. ncbi A 1-year Aspergillus terreus surveillance study at the University Hospital of Innsbruck: molecular typing of environmental and clinical isolates
    G Blum
    Department of Hygiene, Microbiology and Social Medicine, Innsbruck Medical University, Innsbruck, Austria
    Clin Microbiol Infect 14:1146-51. 2008
    ..terreus, which is common in the environment of Innsbruck and a source of invasive infections in immunosuppressed patients. Genotypical diversity was found in clinical and environmental A. terreus isolates...
  14. pmc Potential basis for amphotericin B resistance in Aspergillus terreus
    Gerhard Blum
    Department of Hygiene, Microbiology and Social Medicine, Innsbruck Medical University, Innsbruck, Austria
    Antimicrob Agents Chemother 52:1553-5. 2008
    ..terreus was significantly higher than that in A. fumigatus (P < 0.05). This higher-level production may contribute to AMB resistance in A. terreus since oxidative damage has been implicated in AMB action...
  15. pmc In vitro activities of various antifungal drugs against Aspergillus terreus: Global assessment using the methodology of the European committee on antimicrobial susceptibility testing
    Cornelia Lass-Flörl
    Department of Hygiene, Microbiology and Social Medicine, Innsbruck Medical University, Austria
    Antimicrob Agents Chemother 53:794-5. 2009
    ..Posaconazole and anidulafungin had the lowest and amphotericin B the highest MICs. No differences in susceptibility patterns were observed between environmental and clinical isolates...
  16. pmc Activities of antifungal agents against yeasts and filamentous fungi: assessment according to the methodology of the European Committee on Antimicrobial Susceptibility Testing
    Cornelia Lass-Flörl
    Department of Hygiene, Microbiology and Social Medicine, Innsbruck Medical University, Fritz Pregl Str 3, Innsbruck 6020, Austria
    Antimicrob Agents Chemother 52:3637-41. 2008
    ..AMB, l-AMB, and POS were active against the majority of pathogens, including species that cause rare and difficult-to-treat infections...
  17. doi In vitro susceptibility testing in fungi: a global perspective on a variety of methods
    Cornelia Lass-Flörl
    Department of Hygiene, Microbiology and Social Medicine, Division of Hygiene and Medical Microbiology, Innsbruck Medical University, Innsbruck, Austria
    Mycoses 53:1-11. 2010
    ..Early recognition of infections caused by pathogens that are resistant to one or more antifungals is highly warranted to optimise treatment and patient outcome...
  18. doi In vitro susceptibility-testing in Aspergillus species
    Cornelia Lass-Flörl
    Department of Hygiene and Clinical Microbiology, University of Innsbruck, Innsbruck, Austria
    Mycoses 51:437-46. 2008
    ..EUCAST-AFST-ASPERGILLUS) defining breakpoints. This paper reviews the available methods for antifungal susceptibility-testing in Aspergillus spp. as well as the scant data regarding the clinical implications of in vitro testing...
  19. doi The Nationwide Austrian Aspergillus Registry: a prospective data collection on epidemiology, therapy and outcome of invasive mould infections in immunocompromised and/or immunosuppressed patients
    S Perkhofer
    Division of Hygiene and Medical Microbiology, Innsbruck Medical University, Fritz Pregl Str 3 III, 6020 Innsbruck, Austria
    Int J Antimicrob Agents 36:531-6. 2010
    ..Survival from IMIs appears to have improved and the main challenge is to overcome breakthrough fungal infections...
  20. ncbi Immune evasion by acquisition of complement inhibitors: the mould Aspergillus binds both factor H and C4b binding protein
    G Vogl
    Department for Hygiene, Microbiology and Social Medicine, Innsbruck Medical University, Austria
    Mol Immunol 45:1485-93. 2008
    ..appears to be even stronger than to Candida spp. and that different, albeit possibly nearby, binding moieties mediate this surface attachment...
  21. ncbi Austrian clinical practice with anidulafungin in 2008: a multicenter survey
    S Perkhofer
    Division of Hygiene and Medical Microbiology, Innsbruck Medical University, Innsbruck, Austria
    J Chemother 23:285-9. 2011
    ..No breakthrough IFI and few adverse events were reported. Overall, favorable clinical experiences were documented with anidulafungin in the clinical routine setting...