Stefan Kiechl

Summary

Affiliation: Innsbruck Medical University
Country: Austria

Publications

  1. ncbi Osteoprotegerin is a risk factor for progressive atherosclerosis and cardiovascular disease
    Stefan Kiechl
    Department of Neurology, University Clinic, Anichstrasse 35, A 6020 Innsbruck, Austria
    Circulation 109:2175-80. 2004
  2. ncbi The osteoprotegerin/RANK/RANKL system: a bone key to vascular disease
    Stefan Kiechl
    Medical University Innsbruck, Department of Neurology, Anichstr 35, A 6020 Innsbruck, Austria
    Expert Rev Cardiovasc Ther 4:801-11. 2006
  3. ncbi Blockade of receptor activator of nuclear factor-κB (RANKL) signaling improves hepatic insulin resistance and prevents development of diabetes mellitus
    Stefan Kiechl
    Department of Neurology, Medical University Innsbruck, Innsbruck, Austria
    Nat Med 19:358-63. 2013
  4. ncbi Soluble receptor activator of nuclear factor-kappa B ligand and risk for cardiovascular disease
    Stefan Kiechl
    Department of Neurology, Innsbruck Medical University, Anichstr 35, A 6020 Innsbruck, Austria
    Circulation 116:385-91. 2007
  5. ncbi Kaleidoscopic vision and a jerking leg on the ski slope
    Stefan Kiechl
    Department of Neurology, Medical University Innsbruck, Austria
    Lancet 370:1878. 2007
  6. ncbi Cellular aging reflected by leukocyte telomere length predicts advanced atherosclerosis and cardiovascular disease risk
    Peter Willeit
    Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    Arterioscler Thromb Vasc Biol 30:1649-56. 2010
  7. ncbi Sex and age interaction with genetic association of atherogenic uric acid concentrations
    Anita Brandstätter
    Division of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Innsbruck Medical University, Schöpfstr 41, A 6020 Innsbruck, Austria
    Atherosclerosis 210:474-8. 2010
  8. ncbi Coronary artery disease-related genetic variant on chromosome 10q11 is associated with carotid intima-media thickness and atherosclerosis
    Stefan Kiechl
    Department of Neurology, Medical University Innsbruck, Innsbruck, Austria
    Arterioscler Thromb Vasc Biol 30:2678-83. 2010
  9. ncbi Oxidized phospholipids, lipoprotein(a), lipoprotein-associated phospholipase A2 activity, and 10-year cardiovascular outcomes: prospective results from the Bruneck study
    Stefan Kiechl
    Department of Neurology, Medical University of Innsbruck, Austria
    Arterioscler Thromb Vasc Biol 27:1788-95. 2007
  10. ncbi Telomere length and risk of incident cancer and cancer mortality
    Peter Willeit
    Department of Neurology, Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, Austria
    JAMA 304:69-75. 2010

Detail Information

Publications53

  1. ncbi Osteoprotegerin is a risk factor for progressive atherosclerosis and cardiovascular disease
    Stefan Kiechl
    Department of Neurology, University Clinic, Anichstrasse 35, A 6020 Innsbruck, Austria
    Circulation 109:2175-80. 2004
    ..Recent experimental research has implicated osteoprotegerin in atherogenesis, but epidemiological confirmation of this concept is sparse...
  2. ncbi The osteoprotegerin/RANK/RANKL system: a bone key to vascular disease
    Stefan Kiechl
    Medical University Innsbruck, Department of Neurology, Anichstr 35, A 6020 Innsbruck, Austria
    Expert Rev Cardiovasc Ther 4:801-11. 2006
    ..RANKL in turn may be a suitable target for novel therapies. Pharmacological strategies for specific interference with the OPG/RANK/RANKL axis are currently being developed and evaluated in osteoporosis therapy...
  3. ncbi Blockade of receptor activator of nuclear factor-κB (RANKL) signaling improves hepatic insulin resistance and prevents development of diabetes mellitus
    Stefan Kiechl
    Department of Neurology, Medical University Innsbruck, Innsbruck, Austria
    Nat Med 19:358-63. 2013
    ..Overall, this study provides evidence for a role of RANKL signaling in the pathogenesis of T2DM. If so, translation to the clinic may be feasible given current pharmacological strategies to lower RANKL activity to treat osteoporosis...
  4. ncbi Soluble receptor activator of nuclear factor-kappa B ligand and risk for cardiovascular disease
    Stefan Kiechl
    Department of Neurology, Innsbruck Medical University, Anichstr 35, A 6020 Innsbruck, Austria
    Circulation 116:385-91. 2007
    ....
  5. ncbi Kaleidoscopic vision and a jerking leg on the ski slope
    Stefan Kiechl
    Department of Neurology, Medical University Innsbruck, Austria
    Lancet 370:1878. 2007
  6. ncbi Cellular aging reflected by leukocyte telomere length predicts advanced atherosclerosis and cardiovascular disease risk
    Peter Willeit
    Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    Arterioscler Thromb Vasc Biol 30:1649-56. 2010
    ..To determine the association between leukocyte telomere length (TL) and atherosclerosis and its clinical sequelae stroke and myocardial infarction...
  7. ncbi Sex and age interaction with genetic association of atherogenic uric acid concentrations
    Anita Brandstätter
    Division of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Innsbruck Medical University, Schöpfstr 41, A 6020 Innsbruck, Austria
    Atherosclerosis 210:474-8. 2010
    ..High serum uric acid levels are associated with gout, atherosclerosis and cardiovascular disease. Three genes (SLC2A9, ABCG2, and SLC17A3) were reported to be involved in the regulation of uric acid levels...
  8. ncbi Coronary artery disease-related genetic variant on chromosome 10q11 is associated with carotid intima-media thickness and atherosclerosis
    Stefan Kiechl
    Department of Neurology, Medical University Innsbruck, Innsbruck, Austria
    Arterioscler Thromb Vasc Biol 30:2678-83. 2010
    ..To investigate whether chromosome 10q11.21 influences common carotid intima-media thickness (IMT) and atherosclerosis and whether it is associated with stromal cell-derived factor-1α (SDF-1α) plasma levels...
  9. ncbi Oxidized phospholipids, lipoprotein(a), lipoprotein-associated phospholipase A2 activity, and 10-year cardiovascular outcomes: prospective results from the Bruneck study
    Stefan Kiechl
    Department of Neurology, Medical University of Innsbruck, Austria
    Arterioscler Thromb Vasc Biol 27:1788-95. 2007
    ..Oxidized phospholipids (OxPL) circulate on apolipoprotein B-100 particles (OxPL/apoB), and primarily on Lp(a) lipoprotein (a) [Lp(a)]. The relationship of OxPL/apoB levels to future cardiovascular events is not known...
  10. ncbi Telomere length and risk of incident cancer and cancer mortality
    Peter Willeit
    Department of Neurology, Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, Austria
    JAMA 304:69-75. 2010
    ..Telomeres are essential to preserve the integrity of the genome. Critically short telomeres lead to replicative cell senescence and chromosomal instability and may thereby increase cancer risk...
  11. ncbi Increased risk of atherosclerosis is confined to CagA-positive Helicobacter pylori strains: prospective results from the Bruneck study
    Manuel Mayr
    Institute for Biomedical Aging Research, Austrian Academy of Sciences, Innsbruck, Austria
    Stroke 34:610-5. 2003
    ..CONCLUSIONS: Infections with virulent CagA-bearing H pylori strains may contribute to the pathogenesis of early atherosclerosis by aggravating immune-inflammatory reactions...
  12. ncbi Marburg I polymorphism of factor VII--activating protease: a prominent risk predictor of carotid stenosis
    Johann Willeit
    Department of Neurology, University Clinics, Innsbruck, Austria
    Circulation 107:667-70. 2003
    ..The Marburg I polymorphism of FSAP impairs this potential and may thus facilitate arterial thrombosis...
  13. ncbi Allergic rhinitis, asthma, and atherosclerosis in the Bruneck and ARMY studies
    Michael Knoflach
    Department of Pathophysiology, Innsbruck Medical University, Innsbruck, Austria
    Arch Intern Med 165:2521-6. 2005
    ..Several diseases characterized by chronic inflammation and immune activation have been linked to enhanced risk for atherosclerosis. The potential association between allergies and atherosclerosis, however, remains to be defined...
  14. ncbi Prognostic relevance of limb shaking in symptomatic carotid artery occlusion
    Michael Knoflach
    Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria
    Cerebrovasc Dis 32:35-40. 2011
    ..Reliable data on the frequency of these phenomena and their potential prognostic relevance are still sparse...
  15. ncbi Asymmetric and symmetric dimethylarginines are of similar predictive value for cardiovascular risk in the general population
    Stefan Kiechl
    Department of Neurology, Medical University Innsbruck, Innsbruck, Austria
    Atherosclerosis 205:261-5. 2009
    ..While increased plasma levels of ADMA have been reported in different cardiovascular disease states, its association with symmetric dimethylarginine (SDMA) has not been evaluated in a prospective population-based study...
  16. ncbi A common variant in the adiponutrin gene influences liver enzyme values
    Barbara Kollerits
    Division of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Innsbruck Medical University, , A 6020 Innsbruck, Austria
    J Med Genet 47:116-9. 2010
    ..Conclusion The highly significant associations of this transversion polymorphism within the adiponutrin gene with increased ALT and AST concentrations support a role for adiponutrin as a susceptibility gene for hepatic dysfunction...
  17. ncbi Urinary albumin excretion is independently associated with carotid and femoral artery atherosclerosis in the general population
    Martin Furtner
    Department of Neurology, Innsbruck Medical University Clinic, Anichstrasse 35, A-6020 Innsbruck, Austria
    Eur Heart J 26:279-87. 2005
    ..The novel aspects of our study are its focus on various vascular territories and representivity of the general healthy population...
  18. ncbi Fibrinogen degradation coagulopathy and bleeding complications after stroke thrombolysis
    Benjamin Matosevic
    Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    Neurology 80:1216-24. 2013
    ....
  19. ncbi Influences on the reduction of relative telomere length over 10 years in the population-based Bruneck Study: introduction of a well-controlled high-throughput assay
    Silvia Ehrlenbach
    Division of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Innsbruck Medical University, Innsbruck, Austria
    Int J Epidemiol 38:1725-34. 2009
    ..Short telomeres are linked to age-associated diseases and cancer. Our aim was to determine the decrease rate of relative telomere length (RTL) over 10 years and whether this rate was influenced by age, sex and smoking behaviour...
  20. ncbi Cardiovascular risk factors and atherosclerosis in young males: ARMY study (Atherosclerosis Risk-Factors in Male Youngsters)
    Michael Knoflach
    Institute for Biomedical Ageing Research, Austrian Academy of Sciences, Innsbruck, Austria
    Circulation 108:1064-9. 2003
    ..CONCLUSIONS: Our study supports the concept that atherosclerosis begins in the first decades of life and suggests a role of the immune system, especially immunoreactivity against HSP60s, in atherosclerosis of young individuals...
  21. ncbi Pentraxin-3 as a marker of advanced atherosclerosis results from the Bruneck, ARMY and ARFY Studies
    Michael Knoflach
    Department of Neurology, Medical University, Innsbruck, Austria
    PLoS ONE 7:e31474. 2012
    ..Pentraxins like C-reactive protein are key components of the innate immune system. Recently, pentraxin-3 (PTX3) has been proposed to be a specific marker of vascular inflammation, yet its association with atherosclerosis is still unclear...
  22. ncbi Non-toxic cadmium concentrations induce vascular inflammation and promote atherosclerosis
    Michael Knoflach
    Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    Circ J 75:2491-5. 2011
    ..Cadmium is a potential new risk factor for early atherosclerosis and cardiovascular diseases in humans, yet pathogenetic mechanisms are still a matter of debate...
  23. ncbi [Juvenile stroke--results from the Austrian Stroke Registry]
    Michael Knoflach
    Universitätsklinik für Neurologie, Medizinische Universitat Innsbruck, Innsbruck, Austria
    Wien Med Wochenschr 158:453-7. 2008
    ..Young men experience a significant delay in the onset-to-door time in comparison to other segments of the population. Increasing awareness about the relevance of stroke in the young is a valuable target for future health campaigns...
  24. ncbi Subtherapeutic warfarin therapy entails an increased bleeding risk after stroke thrombolysis
    Michael Ruecker
    Department of Neurology, Medical University Innsbruck, Innsbruck, Austria
    Neurology 79:31-8. 2012
    ..To quantify the risk for bleeding complications after thrombolysis for ischemic stroke in patients on warfarin (international normalized ratio [INR] ≤ 1.7) and to put these data into perspective with previous studies...
  25. ncbi Stroke thrombolysis: having more time translates into delayed therapy: data from the Austrian Stroke Unit Registry
    Julia Ferrari
    Department of Neurology, Hospital Barmherzige Brueder, Vienna, Austria
    Stroke 41:2001-4. 2010
    ..Previous small-scale studies suggested that the earlier patients arrive, the longer it takes to administer recombinant tissue plasminogen activator...
  26. ncbi Cardiovascular risk factors and atherosclerosis in young women: atherosclerosis risk factors in female youngsters (ARFY study)
    Michael Knoflach
    Department of Clinical Neurology, Innsbruck Medical University, Innsbruck, Austria
    Stroke 40:1063-9. 2009
    ..Little research has been conducted into risk factors of atherosclerosis development in young women...
  27. ncbi Cadmium is a novel and independent risk factor for early atherosclerosis mechanisms and in vivo relevance
    Barbara Messner
    Cardiac Surgery Research Laboratory, Department of Cardiac Surgery, Innsbruck Medical University, Austria
    Arterioscler Thromb Vasc Biol 29:1392-8. 2009
    ..Although cadmium (Cd) is an important and common environmental pollutant and has been linked to cardiovascular diseases, little is known about its effects in initial stages of atherosclerosis...
  28. ncbi Recanalization of extracranial internal carotid artery occlusion after i.v. thrombolysis for acute ischemic stroke
    Raimund Pechlaner
    Department of Neurology, Innsbruck Medical University, Innsbruck, Tyrol, Austria
    PLoS ONE 8:e55318. 2013
    ....
  29. ncbi Identification of atherosclerosis-associated conformational heat shock protein 60 epitopes by phage display and structural alignment
    Hannes Perschinka
    Division of Experimental Pathophysiology and Immunology, Biocenter, Innsbruck Medical University, Fritz Pregl Str 3 IV, 6020 Innsbruck, Austria
    Atherosclerosis 194:79-87. 2007
    ....
  30. ncbi Toll-like receptor 4 and atherogenesis
    Stefan Kiechl
    Department of Neurology, Innsbruck University Clinic, Innsbruck, Austria
    Ann Med 35:164-71. 2003
    ..The aim of this review is to critically discuss current experimental and epidemiological evidence for a role of TLR4 in atherogenesis and to highlight the main controversies and perspectives in this emerging field of vascular biology...
  31. ncbi Prevalence of movement disorders in men and women aged 50-89 years (Bruneck Study cohort): a population-based study
    Gregor K Wenning
    Department of Neurology, Medical University Innsbruck, Innsbruck, Austria
    Lancet Neurol 4:815-20. 2005
    ..A fifth of all movement disorders were diagnosed to be probably drug-induced. INTERPRETATION: There is a high prevalence of and substantial under-recognition and under-treatment of movement disorders in the general community...
  32. ncbi Progressive leukoencephalopathy caused by primary CNS lymphoma
    Benjamin Matosevic
    Department of Neurology, Medical University Innsbruck, Innsbruck 6020, Austria
    J Clin Pathol 63:359-61. 2010
    ..This report intends to increase awareness among neurologists and other stroke physicians about this disease in order to accelerate diagnosis and initiation of treatment...
  33. ncbi Active and passive smoking, chronic infections, and the risk of carotid atherosclerosis: prospective results from the Bruneck Study
    Stefan Kiechl
    Department of Neurology, Innsbruck University Hospital, Innsbruck, Austria
    Stroke 33:2170-6. 2002
    ..The present study sought to estimate the contribution of chronic infections to the variability of atherosclerosis severity among smokers...
  34. ncbi Genetic evidence for a role of adiponutrin in the metabolism of apolipoprotein B-containing lipoproteins
    Barbara Kollerits
    Division of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Innsbruck Medical University, Innsbruck, Austria
    Hum Mol Genet 18:4669-76. 2009
    ..We did not observe clear evidence for associations with HDL cholesterol or triglyceride concentrations. In conclusion, our study suggests that adiponutrin is involved in the metabolism of apoB-containing lipoproteins...
  35. ncbi Neonatal characteristics and risk of atopic asthma in schoolchildren: results from a large prospective birth-cohort study
    Ursula Kiechl-Kohlendorfer
    Department of Paediatrics, Division of Neonatology, Neuropaediatrics and Metabolic Diseases, Innsbruck Medical University, Innsbruck, Austria
    Acta Paediatr 96:1606-10. 2007
    ..Identification of risk predictors for a hospitalization for atopic asthma in childhood may help design prevention programmes and improve our understanding of disease pathobiology...
  36. ncbi Association of variation at the ABO locus with circulating levels of soluble intercellular adhesion molecule-1, soluble P-selectin, and soluble E-selectin: a meta-analysis
    Stefan Kiechl
    Innsbruck Medical University, Innsbruck, Austria
    Circ Cardiovasc Genet 4:681-6. 2011
    ..To evaluate these associations and the effect sizes, we performed a meta-analysis with new and previous reported data for polymorphism rs579459...
  37. ncbi Sex-specific association of the putative fructose transporter SLC2A9 variants with uric acid levels is modified by BMI
    Anita Brandstätter
    Department of Medical Genetics, Molecular and ClinicalPharmacology, Division of Genetic Epidemiology, Innsbruck Medical University, Innsbruck, Austria
    Diabetes Care 31:1662-7. 2008
    ..The aim of the present study was to examine the association of four single nucleotide polymorphisms within this gene with uric acid levels and to determine whether this association is modified by obesity...
  38. ncbi A case of a traumatic trigeminal-cavernous fistula occluded by coil embolization
    Benjamin Matosevic
    Department of Neurology, Medical University Innsbruck, Anichstraße 35, 6020 Innsbruck
    J Neuroimaging 21:280-2. 2011
    ..A trigeminal artery as the most common persisting embryonic carotid-basilar anastomosis is found in up to .2% of adults. In rare instances, trigeminal-cavernous fistulas develop either spontaneously or after a trauma...
  39. ncbi Circulating microRNAs as novel biomarkers for platelet activation
    Peter Willeit
    Department of Neurology, Medical University Innsbruck, Austria
    Circ Res 112:595-600. 2013
    ..MicroRNA (miRNA) biomarkers are attracting considerable interest. Effects of medication, however, have not been investigated thus far...
  40. ncbi Toll-like receptor 4 polymorphisms and atherogenesis
    Stefan Kiechl
    Department of Neurology, University Clinic, Innsbruck, Austria
    N Engl J Med 347:185-92. 2002
    ..We determined whether recently discovered genetic variants of toll-like receptor 4 (TLR4) that confer differences in the inflammatory response elicited by bacterial lipopolysaccharide are related to the development of atherosclerosis...
  41. ncbi Serum leptin level and the risk of nontraumatic fracture
    Georg Schett
    Division of Rheumatology, Department of Internal Medicine III, University of Vienna, Austria
    Am J Med 117:952-6. 2004
  42. ncbi Insulin resistance as estimated by homeostasis model assessment predicts incident symptomatic cardiovascular disease in caucasian subjects from the general population: the Bruneck study
    Enzo Bonora
    Endocrinologia e Malattie del Metabolismo, Ospedale Maggiore, Piazzale Stefani 1, 37126 Verona, Italy
    Diabetes Care 30:318-24. 2007
    ....
  43. ncbi Oxidized phospholipids predict the presence and progression of carotid and femoral atherosclerosis and symptomatic cardiovascular disease: five-year prospective results from the Bruneck study
    Sotirios Tsimikas
    Department of Medicine, University of California San Diego, La Jolla, California 92093 0682, USA
    J Am Coll Cardiol 47:2219-28. 2006
    ..The purpose of this work was to determine the predictive value of oxidized phospholipids (OxPLs) present on apolipoprotein B-100 particles (apoB) in carotid and femoral atherosclerosis...
  44. ncbi Endothelial progenitor cells, cardiovascular risk factors, cytokine levels and atherosclerosis--results from a large population-based study
    Qingzhong Xiao
    Cardiovascular Division, King s College London, University of London, London, United Kingdom
    PLoS ONE 2:e975. 2007
    ..Finally, we demonstrate a significant inverse association between EPC number and extent of carotid atherosclerosis even though this association was only of moderate strength and not entirely consistent in other vascular territories...
  45. ncbi Association of serum-soluble heat shock protein 60 with carotid atherosclerosis: clinical significance determined in a follow-up study
    Qingzhong Xiao
    Department of Cardiac and Vascular Sciences, St George s University of London, United Kingdom
    Stroke 36:2571-6. 2005
    ..In the current evaluation, we tested the hypothesis that sHSP60 levels are associated with the progression of carotid arteriosclerosis, prospectively...
  46. ncbi Common CCR5-del32 frameshift mutation associated with serum levels of inflammatory markers and cardiovascular disease risk in the Bruneck population
    Ali R Afzal
    Department of Clinical Developmental Sciences, St George s University of London, London, SW17 ORE, UK
    Stroke 39:1972-8. 2008
    ..The main aim of this study was to examine potential effect of the CCR5-del32 mutation on systemic inflammation, intima-media thickness in carotid and femoral arteries, and on the indices of cardiovascular disease...
  47. ncbi Population-based incidence rates and risk factors for type 2 diabetes in white individuals: the Bruneck study
    Enzo Bonora
    Division of Endocrinology and Metabolic Diseases, University of Verona Medical School, Verona, Italy
    Diabetes 53:1782-9. 2004
    ....
  48. ncbi Carotid atherosclerosis and coronary heart disease in the metabolic syndrome: prospective data from the Bruneck study
    Enzo Bonora
    Division of Endocrinology and Metabolic Diseases, University of Verona Medical School, Verona, Italy
    Diabetes Care 26:1251-7. 2003
    ..The present study aimed at prospectively evaluating carotid atherosclerosis and coronary heart disease (CHD) in subjects with the metabolic syndrome...
  49. ncbi Association of genetic variation on chromosome 9p21 with susceptibility and progression of atherosclerosis: a population-based, prospective study
    Shu Ye
    Clinical Pharmacology, William Harvey Research Institute, Barts and the London School of Medicine, London, United Kingdom
    J Am Coll Cardiol 52:378-84. 2008
    ....
  50. ncbi [Stroke prevention in atrial fibrillation -- transfer of study results to the practice]
    Stefan Kiechl
    Wien Klin Wochenschr 116:817-9. 2004
  51. ncbi Cardiovascular protection in haemophilia
    Stefan Kiechl
    Lancet 362:2026. 2003
  52. ncbi Soluble RANKL and risk of nontraumatic fracture
    Georg Schett
    Department of Internal Medicine III, Division of Rheumatology, University of Vienna, Vienna, Austria
    JAMA 291:1108-13. 2004
    ..The receptor activator of nuclear factor kappaB ligand (RANKL) is essential for osteoclast and, possibly, osteoblast activation and may represent a key link between bone formation and resorption...
  53. ncbi High-sensitivity C-reactive protein and risk of nontraumatic fractures in the Bruneck study
    Georg Schett
    Department of Internal Medicine III and Institute for Clinical Immunology, University of Erlangen Nuremberg, Erlangen, Germany
    Arch Intern Med 166:2495-501. 2006
    ..It is unknown, however, whether low-grade inflammation in healthy individuals, as estimated by the high-sensitivity C-reactive protein (hs-CRP) level, interferes with bone metabolism and affects the risk of nontraumatic fractures...