Dietmar Fuchs

Summary

Affiliation: Innsbruck Medical University
Country: Austria

Publications

  1. pmc Fatigue in patients with lung cancer is related with accelerated tryptophan breakdown
    Katharina Kurz
    Division of Biological Chemistry, Biocenter, Medical University, Innsbruck, Austria
    PLoS ONE 7:e36956. 2012
  2. pmc Accelerated tryptophan degradation predicts poor survival in trauma and sepsis patients
    Martin Ploder
    Department of Surgery, Medical University of Vienna
    Int J Tryptophan Res 3:61-7. 2010
  3. pmc IDO-Mediated Tryptophan Degradation in the Pathogenesis of Malignant Tumor Disease
    Robert Sucher
    Center of Operative Medicine, Department of Visceral, Transplant and Thoracic Surgery
    Int J Tryptophan Res 3:113-20. 2010
  4. pmc TiO(2) nanoparticles and bulk material stimulate human peripheral blood mononuclear cells
    Kathrin Becker
    Division of Biological Chemistry, Biocenter, Innsbruck Medical University, Innsbruck, Austria
    Food Chem Toxicol 65:63-9. 2014
  5. ncbi request reprint Immunoregulatory impact of food antioxidants
    Johanna Gostner
    Division of Biological Chemistry, Biocenter, Innsbruck Medical University, Innrain 80, 6020 Innsbruck, Austria
    Curr Pharm Des 20:840-9. 2014
  6. pmc Cerebrospinal fluid neopterin decay characteristics after initiation of antiretroviral therapy
    Aylin Yilmaz
    Department of Infectious Diseases, University of Gothenburg, Journalvagen 10, Gothenburg, 416 50, Sweden
    J Neuroinflammation 10:62. 2013
  7. pmc Antimalarial drug chloroquine counteracts activation of indoleamine (2,3)-dioxygenase activity in human PBMC
    Johanna M Gostner
    Division of Medical Biochemistry, Biocenter, Innsbruck Medical University, 6020 Innsbruck, Austria
    FEBS Open Bio 2:241-5. 2012
  8. pmc The cerebrospinal fluid proteome in HIV infection: change associated with disease severity
    Thomas E Angel
    Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, USA
    Clin Proteomics 9:3. 2012
  9. pmc An update on the strategies in multicomponent activity monitoring within the phytopharmaceutical field
    Johanna M Gostner
    Division of Medical Biochemistry, Biocenter, Innsbruck Medical University, Fritz Pregl Str 3, 6020 Innsbruck, Austria
    BMC Complement Altern Med 12:18. 2012
  10. doi request reprint Decline of exhaled isoprene in lung cancer patients correlates with immune activation
    D Fuchs
    Division of Biological Chemistry, Biocenter, Innsbruck Medical University, Innsbruck, Austria
    J Breath Res 6:027101. 2012

Detail Information

Publications136 found, 100 shown here

  1. pmc Fatigue in patients with lung cancer is related with accelerated tryptophan breakdown
    Katharina Kurz
    Division of Biological Chemistry, Biocenter, Medical University, Innsbruck, Austria
    PLoS ONE 7:e36956. 2012
    ..Patients with cancer often suffer from fatigue and decreased quality of life which might be related to the breakdown of essential amino acid tryptophan...
  2. pmc Accelerated tryptophan degradation predicts poor survival in trauma and sepsis patients
    Martin Ploder
    Department of Surgery, Medical University of Vienna
    Int J Tryptophan Res 3:61-7. 2010
    ..Thus, increased IDO activity most likely represents a result of host response to pro-inflammation in patients. Data support a possible role of inflammation-induced IDO in the diminished immunoresponsiveness in patients...
  3. pmc IDO-Mediated Tryptophan Degradation in the Pathogenesis of Malignant Tumor Disease
    Robert Sucher
    Center of Operative Medicine, Department of Visceral, Transplant and Thoracic Surgery
    Int J Tryptophan Res 3:113-20. 2010
    ....
  4. pmc TiO(2) nanoparticles and bulk material stimulate human peripheral blood mononuclear cells
    Kathrin Becker
    Division of Biological Chemistry, Biocenter, Innsbruck Medical University, Innsbruck, Austria
    Food Chem Toxicol 65:63-9. 2014
    ..Because neopterin was stimulated and tryptophan breakdown was suppressed in parallel, data suggests that the total effect of particles would be strongly pro-inflammatory. ..
  5. ncbi request reprint Immunoregulatory impact of food antioxidants
    Johanna Gostner
    Division of Biological Chemistry, Biocenter, Innsbruck Medical University, Innrain 80, 6020 Innsbruck, Austria
    Curr Pharm Des 20:840-9. 2014
    ....
  6. pmc Cerebrospinal fluid neopterin decay characteristics after initiation of antiretroviral therapy
    Aylin Yilmaz
    Department of Infectious Diseases, University of Gothenburg, Journalvagen 10, Gothenburg, 416 50, Sweden
    J Neuroinflammation 10:62. 2013
    ..We studied decay characteristics of neopterin in CSF and blood after commencement of ART in HIV-infected subjects and estimated the set-point levels of CSF neopterin after ART-mediated viral suppression...
  7. pmc Antimalarial drug chloroquine counteracts activation of indoleamine (2,3)-dioxygenase activity in human PBMC
    Johanna M Gostner
    Division of Medical Biochemistry, Biocenter, Innsbruck Medical University, 6020 Innsbruck, Austria
    FEBS Open Bio 2:241-5. 2012
    ..These anti-inflammatory effects may relate to the therapeutic benefit of chloroquine in inflammatory conditions and may widen the spectrum of its clinical applications...
  8. pmc The cerebrospinal fluid proteome in HIV infection: change associated with disease severity
    Thomas E Angel
    Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, USA
    Clin Proteomics 9:3. 2012
    ..abstract:..
  9. pmc An update on the strategies in multicomponent activity monitoring within the phytopharmaceutical field
    Johanna M Gostner
    Division of Medical Biochemistry, Biocenter, Innsbruck Medical University, Fritz Pregl Str 3, 6020 Innsbruck, Austria
    BMC Complement Altern Med 12:18. 2012
    ..However, multicomponent preparations are gaining increasing importance in the phytopharmaceutical field by demonstrating beneficial properties with respect to efficacy and toxicity...
  10. doi request reprint Decline of exhaled isoprene in lung cancer patients correlates with immune activation
    D Fuchs
    Division of Biological Chemistry, Biocenter, Innsbruck Medical University, Innsbruck, Austria
    J Breath Res 6:027101. 2012
    ..Interestingly, similar relationships between elevated neopterin and decreased lipid concentrations have been reported earlier in other clinical conditions, e.g. in patients with HIV-1 infection...
  11. pmc Effect of dipterinyl calcium pentahydrate on hepatitis B virus replication in transgenic mice
    Phillip Moheno
    SanRx Pharmaceuticals, Inc, 603 Colima Street, La Jolla, California 92037 8032, USA
    J Transl Med 8:32. 2010
    ..DCP also inhibits indoleamine 2,3-dioxygenase (IDO), an immuno-inhibitory enzyme, in human PBMCs (Peripheral Blood Mononuclear Cells)...
  12. pmc Intact indoleamine 2,3-dioxygenase activity in human chronic granulomatous disease
    Birgit Jürgens
    Children s Cancer Research Institute, Zimmermannplatz 10, A 1090, Vienna, Austria
    Clin Immunol 137:1-4. 2010
    ..Thus, in humans, ROI apparently are dispensable for IDO activity. Hyperinflammation in human CGD cannot be attributed to disabled IDO activation...
  13. pmc Minocycline fails to modulate cerebrospinal fluid HIV infection or immune activation in chronic untreated HIV-1 infection: results of a pilot study
    Emily L Ho
    Department of Neurology1 University of California San Francisco, San Francisco, CA, USA
    AIDS Res Ther 8:17. 2011
    ..abstract:..
  14. pmc Cerebrospinal fluid neopterin: an informative biomarker of central nervous system immune activation in HIV-1 infection
    Lars Hagberg
    Department of Infectious Diseases, Sahlgrenska University Hospital, University of Gothenburg SE 41685 Sweden
    AIDS Res Ther 7:15. 2010
    ....
  15. ncbi request reprint The role of neopterin in atherogenesis and cardiovascular risk assessment
    D Fuchs
    Division of Biological Chemistry, Biocenter, Innsbruck Medical University, Innsbruck, Austria
    Curr Med Chem 16:4644-53. 2009
    ..The present article reviews the role of neopterin in the pathogenesis of cardiovascular disease and as a marker of coronary artery disease progression...
  16. ncbi request reprint Crucial role of interferon-gamma and stimulated macrophages in cardiovascular disease
    Katharina Schroecksnadel
    Division of Biological Chemistry, Biocentre, Innsbruck Medical University, and Ludwig Boltzmann Institute of AIDS Research, Fritz Pregl Strasse 3, A 6020 Innsbruck, Austria
    Curr Vasc Pharmacol 4:205-13. 2006
    ..Anti-inflammatory and immunosuppressive treatment (e.g. with non-steroidal anti-inflammatory drugs or statins) may among other consequences, also contribute to a slow-down of the adverse effects of interferon-gamma...
  17. doi request reprint Neopterin, a prognostic marker in human malignancies
    Robert Sucher
    Center of Operative Medicine, Department of Visceral, Transplant, and Thoracic Surgery, Innsbruck Medical University, Austria
    Cancer Lett 287:13-22. 2010
    ..It contributes to a better understanding how immune activation is involved in the development of tumor-induced immune escape and tumor antigen specific tolerance...
  18. ncbi request reprint Hyperhomocysteinaemia and immune activation in patients with cancer
    Katharina Schroecksnadel
    Division of Biological Chemistry, Biocentre, Innsbruck Medical University, Innsbruck, Austria
    Clin Chem Lab Med 45:47-53. 2007
    ..Recently, homocysteine production was observed in tumour cell lines and homocysteine was proposed as a tumour marker. Furthermore, homocysteine production by activated immunocompetent cells was demonstrated...
  19. ncbi request reprint St. John's wort (Hypericum perforatum) counteracts cytokine-induced tryptophan catabolism in vitro
    Christiana Winkler
    Institute of Medical Chemistry and Biochemistry, Innsbruck Medical University, A 6020 Innsbruck, Austria
    Biol Chem 385:1197-202. 2004
    ..Our results suggest that the reduction of tryptophan degradation by H. perforatum might be important in the action of the plant as an antidepressant...
  20. ncbi request reprint Increasing production of homocysteine and neopterin and degradation of tryptophan with older age
    Barbara Frick
    Institute of Medical Chemistry and Biochemistry, Leopold Franzens University, Innsbruck, Austria
    Clin Biochem 37:684-7. 2004
    ..Homocysteine is known to be elevated in the elderly, which is possibly due to an insufficient availability of folate, B6, and/or B12...
  21. ncbi request reprint Tryptophan degradation during and after gestation
    Katharina Schröcksnadel
    Institute for Medical Chemistry and Biochemistry, University of Innsbruck, Fritz Pregl Strasse 3, A 6020 Innsbruck, Austria
    Adv Exp Med Biol 527:77-83. 2003
    ..Sustained increase of kynurenine postpartum seems independent from immune activation process, rather it seems related to abnormal activity of liver enzymes...
  22. doi request reprint Interferon-gamma-mediated pathways and in vitro PBMC proliferation in HIV-infected patients
    Katharina Schroecksnadel
    Department of General Internal Medicine, University Clinic of Innsbruck, Medical University of Innsbruck, and Central Institute of Blood Transfusion and Immunology, University Hospital, A 6020 Innsbruck, Austria
    Biol Chem 390:115-23. 2009
    ..In conclusion, induction of IFN-gamma and subsequent enzymes appears to importantly influence the proliferative response of HIV-infected PBMCs in vitro, suggesting a prominent role of the cytokine in the development of immunodeficiency...
  23. ncbi request reprint Diminished quality of life in patients with cancer correlates with tryptophan degradation
    Katharina Schroecksnadel
    Division of Biological Chemistry, Biocenter, Innsbruck Medical University, Fritz Pregl Strasse 3, 6020 Innsbruck, Austria
    J Cancer Res Clin Oncol 133:477-85. 2007
    ..In this study, we compared QoL and fatigue self-rating scores of patients with various types of malignancy with tryptophan metabolic changes and immune activation status...
  24. ncbi request reprint Effective antiretroviral therapy reduces degradation of tryptophan in patients with HIV-1 infection
    Gabriele Neurauter
    Institute for Medical Chemistry and Biochemistry, University of Innsbruck, Fritz Pregl Strasse 3, A 6020 Innsbruck, Austria
    Adv Exp Med Biol 527:317-23. 2003
    ..The data support the concept that immune activation is the common background of IDO activation and could represent an important factor underlying T-cell hyporesponsiveness in HIV infection...
  25. pmc Early increase of plasma homocysteine in sepsis patients with poor outcome
    Martin Ploder
    Department of Surgery, Medical University of Vienna, Vienna, Austria
    Mol Med 16:498-504. 2010
    ..Certainly, the number of patients in our study is still small and results can only be regarded as preliminary...
  26. ncbi request reprint Interleukin-6 stimulation of growth of prostate cancer in vitro and in vivo through activation of the androgen receptor
    Kamilla Malinowska
    Department of Urology, Innsbruck Medical University, Anichstrasse 35, A 6020 Innsbruck, Austria
    Endocr Relat Cancer 16:155-69. 2009
    ..Taken together, data in the present study demonstrate that IL-6 may cause growth of androgen receptor-positive tumours in vitro and in vivo through activation of the androgen receptor...
  27. pmc Pathway-focused bioassays and transcriptome analysis contribute to a better activity monitoring of complex herbal remedies
    Angela Klein
    Division of Medical Biochemistry, Innsbruck Medical University, Center for Chemistry and Biomedicine, Innrain 80 82, Innsbruck, Austria
    BMC Genomics 14:133. 2013
    ..0 Affymetrix arrays. Pathway- and network-oriented analysis elucidated the affected biological processes. The results were validated using reporter gene assays and quantitative real-time PCR...
  28. ncbi request reprint Asymmetric dimethylarginine concentrations decrease in patients with HIV infection under antiretroviral therapy
    Katharina Kurz
    Division of Biological Chemistry, Biocenter, Innsbruck Medical University, Innsbruck, Austria
    Antivir Ther 17:1021-7. 2012
    ....
  29. ncbi request reprint Resveratrol suppresses interferon-gamma-induced biochemical pathways in human peripheral blood mononuclear cells in vitro
    Barbara Wirleitner
    Division of Biological Chemistry, Biocentre, Innsbruck Medical University, Fritz Pregl Strasse 3, A 6020 Innsbruck, Austria
    Immunol Lett 100:159-63. 2005
    ....
  30. ncbi request reprint Atorvastatin suppresses homocysteine formation in stimulated human peripheral blood mononuclear cells
    Katharina Schroecksnadel
    Division of Biological Chemistry, Biocenter, Innsbruck Medical University, and Ludwig Boltzmann Institute of AIDS Research, Innsbruck, Austria
    Clin Chem Lab Med 43:1373-6. 2005
    ..Again, cysteine levels were not influenced by any treatment. The down-regulating effect of atorvastatin on homocysteine formation in vitro indicates that statins may prevent homocysteine accumulation in the blood via immunosuppression...
  31. ncbi request reprint Food preservatives sodium sulfite and sorbic acid suppress mitogen-stimulated peripheral blood mononuclear cells
    Christiana Winkler
    Biocenter, Division of Biological Chemistry, Innsbruck Medical University, Fritz Pregl Strasse 3, A 6020 Innsbruck, Austria
    Food Chem Toxicol 44:2003-7. 2006
    ..01 at 1 mM sodium sulfite and 50 mM sorbic acid). Data demonstrate a suppressive influence of sodium sulfite and sorbic acid on the activated Th1-type immune response...
  32. doi request reprint Food additives such as sodium sulphite, sodium benzoate and curcumin inhibit leptin release in lipopolysaccharide-treated murine adipocytes in vitro
    Christian Ciardi
    Department of Internal Medicine I, Anichstrasse 35, Innsbruck Medical University, A 6020 Innsbruck, Austria
    Br J Nutr 107:826-33. 2012
    ..Decreased leptin release during the consumption of nutrition-derived food additives could decrease the amount of circulating leptin to which the central nervous system is exposed and may therefore contribute to an obesogenic environment...
  33. ncbi request reprint Moderate hyperhomocysteinaemia and immune activation in patients with rheumatoid arthritis
    Katharina Schroecksnadel
    Institute of Medical Chemistry and Biochemistry, University of Innsbruck, Fritz Pregl Strasse 3, A 6020 Innsbruck, Austria
    Clin Chim Acta 338:157-64. 2003
    ..Moderate hyperhomocysteinaemia related to folate deficiency has been described in patients with cardiovascular risk and also in patients with autoimmune diseases including rheumatoid arthritis (RA)...
  34. ncbi request reprint Inverse association between serum selenium concentrations and parameters of immune activation in patients with cardiac disorders
    Christian Murr
    Division of Biological Chemistry, Innsbruck Medical University, Innsbruck, Austria
    Clin Chem Lab Med 45:1224-8. 2007
    ..The aim of this study was to determine the relationship between serum selenium concentrations and neopterin production and tryptophan degradation in patients with cardiac disorders...
  35. ncbi request reprint Tryptophan degradation increases with stage in patients with rheumatoid arthritis
    Katharina Schroecksnadel
    Division of Biological Chemistry, Biocentre Fritz, Innsbruck Medical University, Pregl Strasse 3, 6020 Innsbruck, Austria
    Clin Rheumatol 25:334-7. 2006
    ..It could also be relevant for the mood of patients, as tryptophan is the precursor of serotonin...
  36. doi request reprint Total homocysteine in patients with angiographic coronary artery disease correlates with inflammation markers
    Katharina Schroecksnadel
    Division of Biological Chemistry, Biocenter, Innsbruck Medical University, Fritz Pregl Strasse 3, A 6020 Innsbruck, Austria
    Thromb Haemost 103:926-35. 2010
    ..We conclude that homocysteine accumulation could result from B-vitamin deficiency which is related to chronic immune activation...
  37. doi request reprint LPS-induced NF-kappaB expression in THP-1Blue cells correlates with neopterin production and activity of indoleamine 2,3-dioxygenase
    Sebastian Schroecksnadel
    Division of Biological Chemistry, Innsbruck Medical University, Innsbruck, Austria
    Biochem Biophys Res Commun 399:642-6. 2010
    ..001). We conclude that there is a parallel induction of NF-kappaB, neopterin formation and trp degradation in monocytic THP-1 cells, which is elicited by pro-inflammatory triggers like LPS during innate immune responses...
  38. doi request reprint Increased blood phenylalanine to tyrosine ratio in HIV-1 infection and correction following effective antiretroviral therapy
    Robert Zangerle
    HIV Unit, Department of Dermatology and Venerology, Innsbruck Medical University, Innsbruck, Austria
    Brain Behav Immun 24:403-8. 2010
    ..PAH is rate-limiting in the biosynthesis of dopamine, and impaired PAH activity is reflected by an increased phe to tyr ratio (phe/tyr)...
  39. ncbi request reprint Tryptophan degradation in patients with gynecological cancer correlates with immune activation
    Katharina Schroecksnadel
    Institute of Medical Chemistry and Biochemistry, Innsbruck Medical University, Fritz Pregl Strasse 3, A 6020 Innsbruck, Austria
    Cancer Lett 223:323-9. 2005
    ..The relationship between kyn/trp and neopterin concentrations indicates that cellular immune activation rather than tumor-mediated IDO-activity is responsible (228 words)...
  40. doi request reprint Serum phenylalanine concentrations in patients with ovarian carcinoma correlate with concentrations of immune activation markers and of isoprostane-8
    Gabriele Neurauter
    Division of Biological Chemistry, Biocenter, Innsbruck Medical University, Fritz Pregl Strasse 3, 6020 Innsbruck, Austria
    Cancer Lett 272:141-7. 2008
    ....
  41. ncbi request reprint Vitamin D deficiency parallels inflammation and immune activation, the Ludwigshafen Risk and Cardiovascular Health (LURIC) study
    Christian Murr
    Division of Biological Chemistry, Biocenter, InnsbruckMedical University, Innsbruck, Austria
    Clin Chem Lab Med 50:2205-12. 2012
    ..We investigated whether vitamin D levels in patients with coronary artery disease (CAD) are related to markers of immune activation...
  42. doi request reprint Influence of immunosuppressive agents on tryptophan degradation and neopterin production in human peripheral blood mononuclear cells
    Sebastian Schroecksnadel
    Division of Biological Chemistry, Biocenter, Innsbruck Medical University, Innsbruck, Austria
    Transpl Immunol 25:119-23. 2011
    ..The corresponding changes of IFN-γ concentrations are in line with its role as a trigger of both biochemical changes...
  43. ncbi request reprint Antioxidants suppress Th1-type immune response in vitro
    Katharina Schroecksnadel
    Division of Biological Chemistry, Biocenter, Innsbruck Medical University, Fritz Pregl Str 3, A 6020 Innsbruck, Austria
    Drug Metab Lett 1:166-71. 2007
    ..Antioxidant compounds counteract the activation of T-cells and macrophages. This anti-inflammatory activity could be important for the development of immunotolerance and for treatment of above-mentioned disorders...
  44. ncbi request reprint Antitumoral activity of interferon-gamma involved in impaired immune function in cancer patients
    Gerald Brandacher
    Department of General and Transplant Surgery, Tyrolean Cancer Research Institute, Innsbruck Medical University, Fritz Pregl Strasse 3, A 6020 Innsbruck, Austria
    Curr Drug Metab 7:599-612. 2006
    ....
  45. doi request reprint Food preservatives sodium benzoate and propionic acid and colorant curcumin suppress Th1-type immune response in vitro
    Elisabeth Maier
    Division of Biological Chemistry, Biocenter, Innsbruck Medical University, Innsbruck, Austria
    Food Chem Toxicol 48:1950-6. 2010
    ..Results show an anti-inflammatory property of compounds which however could shift the Th1-Th2-type immune balance towards Th2-type immunity...
  46. doi request reprint Immune activation in patients with Alzheimer's disease is associated with high serum phenylalanine concentrations
    Philipp Wissmann
    Division of Biological Chemistry, Biocenter, Medical University, Innsbruck, Austria
    J Neurol Sci 329:29-33. 2013
    ..In chronic inflammatory conditions, also increased serum phenylalanine concentrations and phenylalanine to tyrosine ratios (Phe/Tyr) were reported and could relate to neuropsychiatric symptoms...
  47. ncbi request reprint Tryptophan degradation in multiple trauma patients: survivors compared with non-survivors
    Martin Ploder
    Department of Surgery, Medical University of Vienna, Vienna, Austria
    Clin Sci (Lond) 116:593-8. 2009
    ..These findings support a possible role for IDO in the development of immunodeficiency and death in patients...
  48. ncbi request reprint Longitudinal study of tryptophan degradation during and after pregnancy
    Katharina Schröcksnadel
    Institute for Medical Chemistry and Biochemistry, University Clinic, A 6020 Innsbruck, Austria
    Life Sci 72:785-93. 2003
    ..We conclude that IDO is activated in pregnancy and that the decrease of tryptophan might be related to immune activation phenomena. Sustained increase of kynurenine postpartum seems independent from immune activation process...
  49. doi request reprint Redox regulation of the immune response
    Johanna M Gostner
    Division of Medical Biochemistry, Biocenter, Medical University, Innsbruck, Austria
    Redox Rep 18:88-94. 2013
    ....
  50. doi request reprint Immunomodulatory effects of Turkish propolis: changes in neopterin release and tryptophan degradation
    Gozde Girgin
    Division of Biological Chemistry, Biocenter, Innsbruck Medical University, Innsbruck, Austria
    Immunobiology 214:129-34. 2009
    ..The suppression of tryptophan degradation by propolis extracts may therefore be related with some of its beneficial health properties in humans...
  51. ncbi request reprint Association of hyperhomocysteinemia in Alzheimer disease with elevated neopterin levels
    Katharina Schroecksnadel
    Institute of Medical Chemistry and Biochemistry, Medical University of Innsbruck, Innsbruck, Austria
    Alzheimer Dis Assoc Disord 18:129-33. 2004
    ..506; p < 0.001). The data suggest that immune activation and concomitant production of reactive oxygen species in patients with AD could be involved in the development of hyperhomocysteinemia via an enhanced decomposition of folate...
  52. ncbi request reprint Association between neopterin in cord blood, urinary neopterin in early childhood and the development of atopic dermatitis, asthma and hay fever
    Elisabeth Horak
    Division of Biological Chemistry Biocentre, University Hospital for Children and Adolescents, Anichstrasse 35, A 6020 Innsbruck, Austria
    Pediatr Allergy Immunol 17:11-6. 2006
    ..Family history of atopic disease was associated with lower urinary neopterin levels at age 6 yr, which might mirror a Th1/Th2 imbalance...
  53. ncbi request reprint Down-regulatory effect of N-chlorotaurine on tryptophan degradation and neopterin production in human PBMC
    Barbara Wirleitner
    Institute of Medical Chemistry and Biochemistry, Medical University of Innsbruck, Fritz Pregl Strasse 3, A 6020 Innsbruck, Austria
    Immunol Lett 93:143-9. 2004
    ..In contrast to earlier results, where NCT was suggested to act primarily down-regulatory on Th2 cells, we propose also a strong suppressive effect of NCT on Th1-type immunity...
  54. ncbi request reprint Increased degradation of tryptophan in blood of patients with rheumatoid arthritis
    Katharina Schroecksnadel
    Institute of Medical Chemistry and Biochemistry, Leopold Franzens University of Innsbruck, Fritz Pregl Strasse 3, A 6020 Innsbruck, Austria
    J Rheumatol 30:1935-9. 2003
    ..Tryptophan deprivation due to IDO activation could therefore be effective in abrogating processes with high metabolic turnover, thus modulating cellular immune response...
  55. ncbi request reprint Bovine colostrum modulates immune activation cascades in human peripheral blood mononuclear cells in vitro
    Marcel Jenny
    Division of Biological Chemistry, Biocenter Innsbruck Medical University, Innsbruck, Austria
    New Microbiol 33:129-35. 2010
    ..The amount of lactose present in BC seems to diminish the activity of BC in our test system, since BC with higher amounts of lactose attenuated the stimulatory as well as the suppressive activity of BC...
  56. ncbi request reprint Antioxidants may increase the probability of developing allergic diseases and asthma
    Christian Murr
    Department of Molecular Cell Biology, Institute for Medical Chemistry and Biochemistry, Innsbruck Medical University, Fritz Pregl Strasse 3, A 6020 Innsbruck, Austria
    Med Hypotheses 64:973-7. 2005
    ....
  57. doi request reprint Enhanced tryptophan degradation in patients with ovarian carcinoma correlates with several serum soluble immune activation markers
    Barbara Sperner-Unterweger
    Department of Psychiatry, Innsbruck Medical University, 6020 Innsbruck, Austria
    Immunobiology 216:296-301. 2011
    ..However IDO activity is not necessarily a spontaneous activity of ovarian cancer cells rather it is elicited by the activated immune system although an additional spontaneous activity of tumor cells cannot be ruled out...
  58. ncbi request reprint Delta9-tetrahydrocannabinol and cannabidiol modulate mitogen-induced tryptophan degradation and neopterin formation in peripheral blood mononuclear cells in vitro
    Marcel Jenny
    Division of Biological Chemistry, Biocenter, Innsbruck Medical University, 6020 Innsbruck, Austria
    J Neuroimmunol 207:75-82. 2009
    ....
  59. ncbi request reprint Measurement of tryptophan, kynurenine and neopterin in women with and without postpartum blues
    Claudia Kohl
    Department of Psychiatry, Innsbruck Medical University, Anichstrasse 35, A 6020 Innsbruck, Austria
    J Affect Disord 86:135-42. 2005
    ..Our study was designed to examine alterations of tryptophan and its catabolic product kynurenine in the postpartum period and to compare them to neopterin as an immunological marker...
  60. doi request reprint Interferon-gamma-mediated pathways are induced in human CD34(+) haematopoietic stem cells
    Katharina Kurz
    Clinical Immunology and Infectious Diseases, Department of Internal Medicine, Innsbruck Medical University, Innsbruck, Austria
    Immunobiology 215:452-7. 2010
    ..In conclusion, stimulation of haematopoietic stem cells with IFN-gamma activates IDO and neopterin formation, and it also exerts an influence on the proliferation of various stem cell populations...
  61. ncbi request reprint Decreased serum tryptophan concentration predicts poor prognosis in malignant melanoma patients
    Georg Weinlich
    Clinical Department of Dermatology and Venerology, Innsbruck Medical University, Innsbruck, Austria
    Dermatology 214:8-14. 2007
    ..Via tryptophan deprivation, IDO activity suppresses T cell proliferation and differentiation and is thought to be a fundamental immune escape mechanism for tumor cells...
  62. ncbi request reprint Bariatric surgery cannot prevent tryptophan depletion due to chronic immune activation in morbidly obese patients
    Gerald Brandacher
    Department of General and Transplant Surgery, Ludwig Boltzmann Institute for AIDS Research, Innsbruck Medical University, Anichstrasse 35, A 6020 Innsbruck, Austria
    Obes Surg 16:541-8. 2006
    ..Bariatric surgery significantly diminishes immune mediators by substantial weight reduction. We examined IDO-mediated tryptophan-catabolism in morbidly obese patients compared to lean individuals...
  63. ncbi request reprint Neopterin in HIV-1 infection
    Barbara Wirleitner
    Institute of Medical Chemistry and Biochemistry, Medical University of Innsbruck, Fritz Pregl Strasse 3, A 6020 Innsbruck, Austria
    Mol Immunol 42:183-94. 2005
    ..The possible impact of neopterin derivatives and of other biochemical pathways induced by interferon-gamma such as indoleamine 2,3-dioxygenase in chronic diseases like HIV-1 infection is discussed...
  64. doi request reprint Parameters of soluble immune activation in vivo correlate negatively with the proliferative capacity of peripheral blood mononuclear cells in vitro in HIV-infected patients
    Katharina Schroecksnadel
    Department of Biological Chemistry, Medical University of Innsbruck, Innsbruck, Austria
    J Acquir Immune Defic Syndr 50:354-9. 2009
    ..The cytokine interferon-gamma, which seems to play an important role in HIV infection, induces neopterin formation and in parallel also tryptophan degradation by the enzyme indoleamine 2,3-dioxygenase...
  65. doi request reprint Low serum zinc levels in patients undergoing coronary angiography correlate with immune activation and inflammation
    Christian Murr
    Division of Biological Chemistry, Biocenter, Innsbruck Medical University, Fritz Pregl Strasse 3, 6020 Innsbruck, Austria
    J Trace Elem Med Biol 26:26-30. 2012
    ..Low serum zinc concentrations are associated with adverse outcomes. To explain this phenomenon we aimed to investigate whether low zinc levels are related to immune activation, renal function and coronary artery disease (CAD)...
  66. ncbi request reprint Homocysteine and serum markers of immune activation in primary dystonia
    Ulf J Muller
    University Hospital of Neurology, Medical University Innsbruck, Innsbruck, Austria
    Mov Disord 20:1663-7. 2005
    ..HCY is a neuronal excitotoxic amino acid and hyperhomocysteinemia is considered an independent vascular risk factor. Further studies are required to define the background of hyperhomocysteinemia in primary dystonia...
  67. doi request reprint In vitro testing for anti-inflammatory properties of compounds employing peripheral blood mononuclear cells freshly isolated from healthy donors
    M Jenny
    Division of Biological Chemistry, Biocenter, Innsbruck Medical University, Fritz Pregl Strasse 3, 6020 Innsbruck, Austria
    Inflamm Res 60:127-35. 2011
    ..Inflammation is crucially involved in a variety of diseases like autoimmune syndromes, cardiovascular and neurodegenerative disorders, cancer, sepsis and allograft rejection...
  68. ncbi request reprint Association between plasma thiols and immune activation marker neopterin in stable coronary heart disease
    Katharina Schroecksnadel
    Department of General Internal Medicine, Innsbruck Medical University, Innsbruck, Austria
    Clin Chem Lab Med 46:648-54. 2008
    ..Studies have associated elevated plasma levels of the thiols homocysteine and cysteine with an increased risk of atherosclerosis. Their relationship with systemic inflammatory parameters and sclerosis scores was investigated in this study...
  69. ncbi request reprint Hyperhomocysteinemia and immune activation
    Katharina Schroecksnadel
    Institute of Medical Chemistry and Biochemistry, University of Innsbruck, Innsbruck, Austria
    Clin Chem Lab Med 41:1438-43. 2003
    ..An enhanced demand for antioxidants as well as folate and vitamin B12 may develop, together with hyperhomocysteinemia, despite sufficient dietary intake...
  70. ncbi request reprint Relationship between homocysteine and neopterin concentrations in patients with gynecological cancer
    Katharina Schroecksnadel
    Division of Biological Chemistry, Biocentre, Innsbruck Medical University, Fritz Pregl Strasse 3, A 6020 Innsbruck, Austria
    Cancer Lett 240:198-202. 2006
    ....
  71. ncbi request reprint Plasma homocysteine and immune activation in patients with malignant melanoma undergoing treatment with IFN-alpha
    Barbara Frick
    Institute of Medical Chemistry and Biochemistry, University of Innsbruck, Fritz Pregl Strasse 3, A 6020 Innsbruck, Austria
    J Interferon Cytokine Res 24:311-7. 2004
    ..These results indicate that IFN-alpha directly activates macrophages to release neopterin and to degrade tryptophan, but obviously treatment with INF-alpha did not affect homocysteine metabolism...
  72. doi request reprint Association between increased tryptophan degradation and depression in cancer patients
    Katharina Kurz
    Clinical Immunology and Infectious Diseases, Department of Internal Medicine I, Innsbruck Medical University, Innsbruck, Austria
    Curr Opin Clin Nutr Metab Care 14:49-56. 2011
    ..A high percentage of patients with malignant disease develops mood disorders or even depression. This review provides an overview, how immune activation and tryptophan degradation might contribute to the development of depression...
  73. ncbi request reprint Calcium-pterin suppresses mitogen-induced tryptophan degradation and neopterin production in peripheral blood mononuclear cells
    Christiana Winkler
    Division of Biological Chemistry, Biocentre, Innsbruck Medical University, Ludwig Boltzmann Institute of AIDS Research, Innsbruck, Austria
    Immunobiology 211:779-84. 2006
    ..The effect of the compound to suppress IDO activity could be of considerable relevance for the antitumoral effect of the compound because activation of the enzyme is considered as an immune-escape mechanism of tumor cells...
  74. ncbi request reprint Neopterin concentrations in blood donors differ between AB0 blood group phenotypes
    Christian Murr
    Division of Biological Chemistry, Biocentre, Innsbruck Medical University, Fritz Pregl Strasse 3, A 6020 Innsbruck, Austria
    Clin Biochem 38:916-9. 2005
    ..Common factors like age, diastolic blood pressure, body mass index, or smoking habits were found to be associated with neopterin concentrations in humans...
  75. ncbi request reprint Association between increased serum cholesterol and signs of depressive mood
    Maximilian Ledochowski
    Department of Internal Medicine, Leopold Franzens University, Innsbruck, Austria
    Clin Chem Lab Med 41:821-4. 2003
    ..Hypercholesterolemia may not necessarily increase the risk of depressive mood, conversely, increased intake of fat and carbohydrates by individuals with depressive mood may increase cholesterol levels...
  76. ncbi request reprint Anti-inflammatory compound resveratrol suppresses homocysteine formation in stimulated human peripheral blood mononuclear cells in vitro
    Katharina Schroecksnadel
    Division of Biological Chemistry, Biocentre, Innsbruck Medical University, and Ludwig Boltzmann Institute of AIDS Research, Innsbruck, Austria
    Clin Chem Lab Med 43:1084-8. 2005
    ..The influence of resveratrol and of all the other compounds on homocysteine production appears to be independent of any direct effect on homocysteine biochemistry...
  77. ncbi request reprint Monitoring tryptophan metabolism in chronic immune activation
    Katharina Schröcksnadel
    Division of Biological Chemistry, Biocentre, Innsbruck Medical University, Fritz Pregl Strasse 3 A 6020 Innsbruck, Austria
    Clin Chim Acta 364:82-90. 2006
    ..As such, monitoring tryptophan metabolism in chronic immunopathology provides a better understanding of the association between immune activation and IDO and its role in the development of immunodeficiency, anemia and mood disorders...
  78. pmc IDO and regulatory T cell support are critical for cytotoxic T lymphocyte-associated Ag-4 Ig-mediated long-term solid organ allograft survival
    Robert Sucher
    Department of Visceral, Transplant and Thoracic Surgery, Innsbruck Medical University, A 6020 Innsbruck, Austria
    J Immunol 188:37-46. 2012
    ..These results have important implications for the clinical development of this costimulatory blocker...
  79. ncbi request reprint Cognitive deterioration in Alzheimer's disease is accompanied by increase of plasma neopterin
    Imrich Blasko
    Department of Psychiatry, Innsbruck Medical University, Anichstrasse 35, A 6020 Innsbruck, Tyrol, Austria
    J Psychiatr Res 41:694-701. 2007
    ..In summary, neopterin concentrations correlated with cognitive decline in AD patients, which might be due to high CMV seropositivity in that population...
  80. doi request reprint Analysis of humoral immune responses in rhesus macaques vaccinated with attenuated SIVmac239Deltanef and challenged with pathogenic SIVmac251
    Doris Freissmuth
    Department of Hygiene, Microbiology and Social Medicine, Innsbruck Medical University, Innsbruck, Austria
    J Med Primatol 39:97-111. 2010
    ....
  81. ncbi request reprint Myelomonocytic THP-1 cells for in vitro testing of immunomodulatory properties of nanoparticles
    Sebastian Schroecksnadel
    Division of Biological Chemistry, Biocenter, Innsbruck Medical University, 6020 Innsbruck, Austria
    J Biomed Nanotechnol 7:209-10. 2011
    ..The method is robust and reproducible in the range of 0.1-1.0 microg/ml of LPS. However, compared to the PBMC assay it will not reveal any effect on the T-cell interaction...
  82. ncbi request reprint IFN-gamma mediated pathways in patients with fatigue and chronic active Epstein Barr virus-infection
    Rosa Bellmann-Weiler
    Department of General Internal Medicine, Clinical Immunology and Infectious Diseases, Innsbruck Medical University, Innsbruck, Austria
    J Affect Disord 108:171-6. 2008
    ..Because tryptophan is a precursor of the neurotransmitter 5-hydroxytryptamine (serotonin), tryptophan depletion by IDO can cause mood disturbances in patients with chronic immune activation...
  83. doi request reprint Inverse association between serum concentrations of neopterin and antioxidants in patients with and without angiographic coronary artery disease
    Christian Murr
    Division of Biological Chemistry, Biocenter, Innsbruck Medical University, Innsbruck, Austria
    Atherosclerosis 202:543-9. 2009
    ..Results suggest that lower concentrations of antioxidant compounds may relate to higher grade of chronic immune activation in patients...
  84. doi request reprint Divergent modulation of Chlamydia pneumoniae infection cycle in human monocytic and endothelial cells by iron, tryptophan availability and interferon gamma
    Rosa Bellmann-Weiler
    Department of Internal Medicine I, Clinical Immunology and Infectious Diseases, Innsbruck, Austria
    Immunobiology 215:842-8. 2010
    ..pneumoniae biology in endothelial, but not monocytic cells. Our results contribute to a better understanding of C. pneumoniae infection and its role in chronic inflammatory diseases such as atherosclerosis...
  85. doi request reprint Urinary neopterin does not reflect the local antitumor immune milieu in ovarian cancer
    Alain G Zeimet
    Department of Obstetrics and Gynecology, Innsbruck Medical University, Anichstrasse 35, 6020, Innsbruck, Austria
    Cancer Immunol Immunother 59:1813-23. 2010
    ..These findings demonstrate that in ovarian carcinomas the unspecific "cancer-related inflammation" contributes to a significant subversion of the adaptive antitumor immune defense mounted at the tumor site...
  86. ncbi request reprint Method for urinary neopterin measurements by HPLC
    Katharina Schroecksnadel
    Division of Biological Chemistry, Biocentre, Innsbruck Medical University, and Ludwig Boltzmann Institute of AIDS Research, 6020 Innsbruck, Austria
    J Biochem Biophys Methods 66:99-100. 2006
    ..The major problem with this method is that the authors did not at all consider possible interferences with related compounds...
  87. doi request reprint Non-peptidic delta-opioid receptor antagonists suppress mitogen-induced tryptophan degradation in peripheral blood mononuclear cells in vitro
    Marcel Jenny
    Division of Biological Chemistry, Biocenter, Innsbruck Medical University, Innsbruck, Austria
    Immunol Lett 118:82-7. 2008
    ..The suppression of tryptophan degradation suggests that the tested delta-opioid antagonists are able to influence the serotonergic system via a non-opioid action...
  88. doi request reprint Performance of a fully automated quantitative neopterin measurement assay in a routine voluntary blood donation setting
    Peter Mayersbach
    Central Institute of Blood Transfusion and Immunology, University Hospital, Innsbruck, Austria
    Clin Chem Lab Med 48:373-7. 2010
    ..When ELISAs were introduced on fully automated test systems to measure neopterin concentrations, results were generally higher and the cut-off was adjusted up to 12 nmol/L...
  89. doi request reprint Effects of adalimumab therapy on disease activity and interferon-γ-mediated biochemical pathways in patients with rheumatoid arthritis
    Katharina Kurz
    Department of General Internal Medicine, Innsbruck Medical University, Innsbruck, Austria
    Autoimmunity 44:235-42. 2011
    ..Our results indicate that anti-TNF therapy does not influence neopterin concentrations or IDO activity in patients with RA, despite a highly significant improvement of patients' disease activity...
  90. ncbi request reprint Mechanism of neopterin-induced myocardial dysfunction in the isolated perfused rat heart
    Agnes Balogh
    Department of Anesthesia and Critical Care Medicine, Innsbruck Medical University, Anichstrasse 35, A 6020 Innsbruck, Austria
    Biochim Biophys Acta 1724:17-22. 2005
    ..Neopterin has to be considered a pathogenic factor in the development of cardiac dysfunction in chronic disease states with high neopterin levels secondary to activation of the immune system...
  91. ncbi request reprint [Anti-inflammatory potential of Padma 28--review of experimental data on the antiatherogenic activity and discussion of the multi-component principle]
    Florian Ueberall
    Division of Medical Biochemistry, Biocenter, Innsbruck Medical School, Osterreich
    Forsch Komplementmed 13:7-12. 2006
    ..Beyond clinical trials, a large number of in vitro and ex vivo studies report various properties and biochemical activities of this complex herbal multicompound...
  92. ncbi request reprint Human granulocytic anaplasmosis in Austria: epidemiological, clinical, and laboratory findings in five consecutive patients from Tyrol, Austria
    Gernot Walder
    Department of Hygiene, Microbiology and Social Medicine, Innsbruck Medical University, Fritz Pregl Str 3, A 6020 Innsbruck, Austria
    Int J Med Microbiol 296:297-301. 2006
    ..All patients were treated with tetracyclines, which led to prompt improvement of the clinical conditions. Anti-platelet antibodies were observed in one of four patients, but remained unchanged after complete covalescence...
  93. doi request reprint Prognostic significance of TPA versus SCC-Ag, CEA and neopterin in carcinoma of the uterine cervix
    Birgit Volgger
    Medical University of Innsbruck, Department of Obstetrics and Gynaecology, Anichstrasse 35, 6020 Innsbruck, Austria
    Cancer Lett 262:183-9. 2008
    ..Prognostic significance of squamous cell carcinoma antigen (SCC-Ag), tissue polypeptide antigen (TPA), carcinoembryonic antigen (CEA) and neopterin in cervical cancer patients was compared...
  94. ncbi request reprint Investigation of bacterial and viral agents and immune status in Behcet's disease patients from Iran
    Eveline U Irschick
    Department of Ophthalmology, Medical University of Innsbruck, Austria
    Int J Rheum Dis 14:298-310. 2011
    ..Behçet's disease (BD) is an autoimmune disorder associated with HLA-B51 positivity. Serologic/genomic findings have suggested microbes as possible causative agents and the geographical distribution suggests environmental influences...
  95. ncbi request reprint Neopterin production, tryptophan degradation, and mental depression--what is the link?
    Bernhard Widner
    Institute of Medical Chemistry and Biochemistry, University of Innsbruck, Fritz Pregl Strasse 3, Innsbruck A 6020, Austria
    Brain Behav Immun 16:590-5. 2002
    ..Activation of IDO could represent an important link between the immunological network and the pathogenesis of depression...
  96. ncbi request reprint Possible role of cytokine-induced tryptophan degradation in anaemia of inflammation
    Guenter Weiss
    Department of Internal Medicine, Leopold Franzens University, Innsbruck, Austria
    Eur J Haematol 72:130-4. 2004
    ....
  97. ncbi request reprint 7,8-Dihydroneopterin induces apoptosis of Jurkat T-lymphocytes via a Bcl-2-sensitive pathway
    Christiane Enzinger
    Institute for Medical Chemistry and Biochemistry, Innsbruck, Austria
    Eur J Cell Biol 81:197-202. 2002
    ..Results suggest that 7,8-dihydroneopterin-induced apoptosis of T-lymphocytes is mediated by a Bcl-2-sensitive pathway...