Research Topics
Species | Imrich BlaskoSummaryAffiliation: Innsbruck Medical University Country: Austria Publications
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Detail Information
Publications
Role of the immune system in the pathogenesis, prevention and treatment of Alzheimer's diseaseImrich Blasko
Department of Psychiatry, University Hospital of Innsbruck, Austria
Drugs Aging 20:101-13. 2003..As adaptive immunity decreases with aging while innate immunity remains intact, immunotherapy for AD will have to be adapted to this situation. Strategies that combine vaccination and inflammatory drug treatment could be considered...
Conversion from mild cognitive impairment to dementia: influence of folic acid and vitamin B12 use in the VITA cohortI Blasko
Department of Psychiatry and Psychotherapy, Division of General and Social Psychiatry, Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, Austria
J Nutr Health Aging 16:687-94. 2012..This study examined the influence of vitamin B12/folic acid intake on the conversion from mild cognitive impairment (MCI) to dementia...- Prospective study on association between plasma amyloid beta-42 and atherosclerotic risk factorsImrich Blasko
Section of Psychiatry and Psychotherapy, Department of General and Social Psychiatry, Innsbruck Medical University, Innsbruck, Austria
J Neural Transm 118:663-72. 2011..The association of vascular risk factors TC, LDL-C, and HbA1c with higher Aβ42 levels might, after confirmation in other cohorts, influence the development of lifestyle interventions concerning plasma Aβ42 and AD... - Plasma amyloid beta-42 independently predicts both late-onset depression and Alzheimer diseaseImrich Blasko
From the Department of Psychiatry and Psychotherapy, Innsbruck Medical University, Austria
Am J Geriatr Psychiatry 18:973-82. 2010..This study examined the association of emerging late-onset depression (LOD) and AD with plasma Aβ42 in a sample of never depressed and not demented persons at baseline... - Effects of medications on plasma amyloid beta (Abeta) 42: longitudinal data from the VITA cohortImrich Blasko
Department of Psychiatry, Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, Austria
J Psychiatr Res 42:946-55. 2008..Whether the use of gingko biloba might prevent the conversion to MCI or AD needs to be proven in prospective, clinical trials... - Conversion from cognitive health to mild cognitive impairment and Alzheimer's disease: prediction by plasma amyloid beta 42, medial temporal lobe atrophy and homocysteineImrich Blasko
Department of Psychiatry, Innsbruck Medical University, Austria
Neurobiol Aging 29:1-11. 2008.... - Plasma amyloid beta protein 42 in non-demented persons aged 75 years: effects of concomitant medication and medial temporal lobe atrophyImrich Blasko
Department of Psychiatry, Innsbruck Medical University, Austria
Neurobiol Aging 26:1135-43. 2005..Considering the increase of Abeta42 plasma levels as a risk factor for AD, any changes induced by medication by long-term use in the peripheral and possibly also in the central compartment, could be of clinical relevance... - Analysis of cerebrospinal fluid of Alzheimer patients. Biomarkers and toxic propertiesJosef Marksteiner
Department of General Psychiatry, Innsbruck Medical University, Innsbruck, Austria
Pharmacology 82:214-20. 2008..We conclude that in CSF of AD patients (at least partly) mature NGF-like immunoreactivity is enhanced, and is masked in a bioassay by the toxic properties of CSF... - Measurement of thirteen biological markers in CSF of patients with Alzheimer's disease and other dementiasImrich Blasko
Department of Psychiatry, Innsbruck Medical University, Innsbruck, Austria
Dement Geriatr Cogn Disord 21:9-15. 2006..It is suggested that the increase in NGF depends on the extent of neurodegeneration of the AD type and the increase in MCP-1 on age... - Cognitive deterioration in Alzheimer's disease is accompanied by increase of plasma neopterinImrich Blasko
Department of Psychiatry, Innsbruck Medical University, Anichstrasse 35, A 6020 Innsbruck, Tyrol, Austria
J Psychiatr Res 41:694-701. 2007..In summary, neopterin concentrations correlated with cognitive decline in AD patients, which might be due to high CMV seropositivity in that population... - How chronic inflammation can affect the brain and support the development of Alzheimer's disease in old age: the role of microglia and astrocytesImrich Blasko
Department of Psychiatry, University Hospital of Innsbruck, Innsbruck, Austria
Aging Cell 3:169-76. 2004..A disturbed balance between the production and the degradation of A beta can trigger chronic inflammatory processes in microglial cells and astrocytes and thus initiate a vicious circle. This leads to a perpetuation of the disease... - Treatment patterns in inpatients with bipolar disorder at a psychiatric university hospital over a 9-year period: focus on mood stabilizersMichaela Walpoth-Niederwanger
Department of Psychiatry and Psychotherapy, Innsbruck Medical University, Innsbruck, Austria
Int Clin Psychopharmacol 27:256-66. 2012..Clinical decision making, usually made on the basis of individual clinical experience, should always be reevaluated using periodically updated evidence-based medicine guidelines... - Efficacy of donepezil treatment in Alzheimer patients with and without subcortical vascular lesionsImrich Blasko
Department of Psychiatry, University Hospital of Innsbruck, Austria
Pharmacology 72:1-5. 2004..These data support previous observations that donepezil therapy is effective in AD patients with and without subcortical vascular lesions...