David Bernhard

Summary

Affiliation: Innsbruck Medical University
Country: Austria

Publications

  1. ncbi request reprint The aging cardiomyocyte: a mini-review
    D Bernhard
    Cardiac Surgery Research Laboratory, Department of Cardiac Surgery, Innsbruck Medical University, Innsbruck, Austria
    Gerontology 54:24-31. 2008
  2. pmc 5-Methoxyleoligin, a lignan from Edelweiss, stimulates CYP26B1-dependent angiogenesis in vitro and induces arteriogenesis in infarcted rat hearts in vivo
    Barbara Messner
    Cardiac Surgery Research Laboratory, Department of Surgery, Medical University of Vienna, Vienna, Austria
    PLoS ONE 8:e58342. 2013
  3. pmc Leoligin, the major lignan from Edelweiss, inhibits intimal hyperplasia of venous bypass grafts
    Ute Reisinger
    Cardiac Surgery Research Laboratory, Department of Cardiac Surgery, Innsbruck Medical University, Innrain 66, A 6020 Innsbruck, Austria
    Cardiovasc Res 82:542-9. 2009
  4. pmc Maternal cigarette smoking and its effect on neonatal lymphocyte subpopulations and replication
    Giovanni Almanzar
    Department of Pediatrics, University of Wuerzburg, Josef Schneider Str 2, 97080 Wuerzburg, Germany
    BMC Pediatr 13:57. 2013
  5. ncbi request reprint Smoking, oxidative stress and cardiovascular diseases--do anti-oxidative therapies fail?
    D Bernhard
    Cardiac Surgery Research Laboratory, Department of Cardiac Surgery, Innsbruck Medical University, Innrain 66, 6020 Innsbruck, Austria
    Curr Med Chem 14:1703-12. 2007
  6. ncbi request reprint Cigarette smoke--an aging accelerator?
    David Bernhard
    Vascular Biology Group, Division Experimental Pathophysiology and Immunology, Biocenter, Innsbruck Medical University, 6020 Innsbruck, Austria
    Exp Gerontol 42:160-5. 2007
  7. ncbi request reprint Increased serum cadmium and strontium levels in young smokers: effects on arterial endothelial cell gene transcription
    David Bernhard
    Vascular Biology Group, Division Experimental Pathophysiology and Immunology, Biocenter, Innsbruck Medical University, Innsbruck, Austria
    Arterioscler Thromb Vasc Biol 26:833-8. 2006
  8. ncbi request reprint Lead contributes to arterial intimal hyperplasia through nuclear factor erythroid 2-related factor-mediated endothelial interleukin 8 synthesis and subsequent invasion of smooth muscle cells
    Iris Zeller
    Cardiac Surgery, Research Laboratories, Department of Surgery, Medical University of Vienna, Vienna, Austria
    Arterioscler Thromb Vasc Biol 30:1733-40. 2010
  9. ncbi request reprint Isogentisin--a novel compound for the prevention of smoking-caused endothelial injury
    Astrid Schmieder
    Vascular Biology Group, Division Experimental Pathophysiology and Immunology, Biocenter, Innsbruck Medical University, Fritz Pregl Str 3 4 OG, 6020 Innsbruck, Austria
    Atherosclerosis 194:317-25. 2007
  10. doi request reprint Ursolic acid causes DNA-damage, p53-mediated, mitochondria- and caspase-dependent human endothelial cell apoptosis, and accelerates atherosclerotic plaque formation in vivo
    Barbara Messner
    Cardiac Surgery, Research Laboratories, Department of Surgery, Medical University of Vienna, Vienna, Austria
    Atherosclerosis 219:402-8. 2011

Collaborators

Detail Information

Publications36

  1. ncbi request reprint The aging cardiomyocyte: a mini-review
    D Bernhard
    Cardiac Surgery Research Laboratory, Department of Cardiac Surgery, Innsbruck Medical University, Innsbruck, Austria
    Gerontology 54:24-31. 2008
    ..Accordingly, aging-related biochemical and cell-biological changes lead to pathophysiological conditions, especially reduced heart function and heart disease...
  2. pmc 5-Methoxyleoligin, a lignan from Edelweiss, stimulates CYP26B1-dependent angiogenesis in vitro and induces arteriogenesis in infarcted rat hearts in vivo
    Barbara Messner
    Cardiac Surgery Research Laboratory, Department of Surgery, Medical University of Vienna, Vienna, Austria
    PLoS ONE 8:e58342. 2013
    ..To overcome this problem we screened for compounds capable of stimulating angiogenesis, and herein investigate the most active molecule, 5-Methoxyleoligin (5ML), in detail...
  3. pmc Leoligin, the major lignan from Edelweiss, inhibits intimal hyperplasia of venous bypass grafts
    Ute Reisinger
    Cardiac Surgery Research Laboratory, Department of Cardiac Surgery, Innsbruck Medical University, Innrain 66, A 6020 Innsbruck, Austria
    Cardiovasc Res 82:542-9. 2009
    ....
  4. pmc Maternal cigarette smoking and its effect on neonatal lymphocyte subpopulations and replication
    Giovanni Almanzar
    Department of Pediatrics, University of Wuerzburg, Josef Schneider Str 2, 97080 Wuerzburg, Germany
    BMC Pediatr 13:57. 2013
    ..However, the effect of cigarette smoking during pregnancy on the lymphocyte subpopulations in newborns has been discussed, controversially...
  5. ncbi request reprint Smoking, oxidative stress and cardiovascular diseases--do anti-oxidative therapies fail?
    D Bernhard
    Cardiac Surgery Research Laboratory, Department of Cardiac Surgery, Innsbruck Medical University, Innrain 66, 6020 Innsbruck, Austria
    Curr Med Chem 14:1703-12. 2007
    ....
  6. ncbi request reprint Cigarette smoke--an aging accelerator?
    David Bernhard
    Vascular Biology Group, Division Experimental Pathophysiology and Immunology, Biocenter, Innsbruck Medical University, 6020 Innsbruck, Austria
    Exp Gerontol 42:160-5. 2007
    ..In this review, we make an attempt to ascribe many of the deleterious effects of smoking on human health to a general principle, namely the acceleration of aging processes by cigarette smoke chemicals...
  7. ncbi request reprint Increased serum cadmium and strontium levels in young smokers: effects on arterial endothelial cell gene transcription
    David Bernhard
    Vascular Biology Group, Division Experimental Pathophysiology and Immunology, Biocenter, Innsbruck Medical University, Innsbruck, Austria
    Arterioscler Thromb Vasc Biol 26:833-8. 2006
    ..In this study, we determined the serum concentrations of aluminum, cadmium (Cd), cobalt, copper, iron, manganese, nickel, lead, strontium (Sr), and zinc of young nonsmokers, passive smokers, and smokers...
  8. ncbi request reprint Lead contributes to arterial intimal hyperplasia through nuclear factor erythroid 2-related factor-mediated endothelial interleukin 8 synthesis and subsequent invasion of smooth muscle cells
    Iris Zeller
    Cardiac Surgery, Research Laboratories, Department of Surgery, Medical University of Vienna, Vienna, Austria
    Arterioscler Thromb Vasc Biol 30:1733-40. 2010
    ..To validate the hypothesis that the toxic heavy metal lead (Pb) may be linked to cardiovascular diseases via the initiation of atherosclerosis, in vivo and in vitro studies were conducted...
  9. ncbi request reprint Isogentisin--a novel compound for the prevention of smoking-caused endothelial injury
    Astrid Schmieder
    Vascular Biology Group, Division Experimental Pathophysiology and Immunology, Biocenter, Innsbruck Medical University, Fritz Pregl Str 3 4 OG, 6020 Innsbruck, Austria
    Atherosclerosis 194:317-25. 2007
    ..Finally, detailed analyses of intracellular oxidative stress and protein oxidation suggest that isogentisin promotes cell survival by activating cellular repair functions...
  10. doi request reprint Ursolic acid causes DNA-damage, p53-mediated, mitochondria- and caspase-dependent human endothelial cell apoptosis, and accelerates atherosclerotic plaque formation in vivo
    Barbara Messner
    Cardiac Surgery, Research Laboratories, Department of Surgery, Medical University of Vienna, Vienna, Austria
    Atherosclerosis 219:402-8. 2011
    ....
  11. pmc Inhibition of cell surface expression of endothelial adhesion molecules by ursolic acid prevents intimal hyperplasia of venous bypass grafts in rats
    Iris Zeller
    Department of Cardiac Surgery, Medical University of Vienna, Vienna, Austria
    Eur J Cardiothorac Surg 42:878-84. 2012
    ..The aim of this study was to test the hypothesis that ursolic acid (UA) may prevent intimal hyperplasia of venous bypass grafts...
  12. ncbi request reprint Cigarette smoke metal-catalyzed protein oxidation leads to vascular endothelial cell contraction by depolymerization of microtubules
    David Bernhard
    Vascular Biology Group, Division of Experimental Pathophysiology and Immunology, Department Biocenter, Innsbruck Medical University, Innsbruck, Austria
    FASEB J 19:1096-107. 2005
    ..Increased permeability of the vascular endothelium is a crucial event in atherogenesis. This work highlights the compounds and mechanisms by which cigarette smoke induces leakiness of the vascular endothelium...
  13. doi request reprint Cigarette smoke is an endothelial stressor and leads to cell cycle arrest
    Blair Henderson
    Biocenter, Laboratory of Autoimmunity, Division of Experimental Pathophysiology and Immunology, Innsbruck Medical University, Innsbruck, Austria
    Atherosclerosis 201:298-305. 2008
    ..An increased stress and inflammation response indicates that endothelial damage from smoking could contribute to immune cell infiltration, while decreased growth rates reduce endothelial layer repair, promoting atherogenesis...
  14. pmc Dynamics of heat shock protein 60 in endothelial cells exposed to cigarette smoke extract
    Simone Barbara Kreutmayer
    Division of Experimental Pathophysiology and Immunology, Innsbruck Biocenter, Innsbruck Medical University, Innsbruck, Austria
    J Mol Cell Cardiol 51:777-80. 2011
    ..Cigarette smoking is one of the most relevant risk factors for atherosclerosis. Herein, we provide evidence that cigarette smoke may initiate atherosclerosis in the sense of the "auto-immune hypothesis of atherosclerosis."..
  15. ncbi request reprint Characteristics of TAV- and BAV-associated thoracic aortic aneurysms--smooth muscle cell biology, expression profiling, and histological analyses
    Stefan Blunder
    Cardiac Surgery Research Laboratory, Surgical Research Laboratories, Department of Surgery, Medical University of Vienna, Vienna, Austria
    Atherosclerosis 220:355-61. 2012
    ....
  16. doi request reprint Smoking and cardiovascular disease: mechanisms of endothelial dysfunction and early atherogenesis
    Barbara Messner
    From the Cardiac Surgery Research Laboratory, Department of Surgery, Medical University of Vienna, Vienna, Austria B M and Cardiac Surgery Research Laboratory Innsbruck, University Clinic for Cardiac Surgery, Innsbruck Medical University, Innsbruck, Austria D B
    Arterioscler Thromb Vasc Biol 34:509-15. 2014
    ..However, we know that smoking cessation is the most effective measure for reversing damage that has already occurred and preventing fatal cardiovascular outcomes. ..
  17. ncbi request reprint Non-toxic cadmium concentrations induce vascular inflammation and promote atherosclerosis
    Michael Knoflach
    Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    Circ J 75:2491-5. 2011
    ..Cadmium is a potential new risk factor for early atherosclerosis and cardiovascular diseases in humans, yet pathogenetic mechanisms are still a matter of debate...
  18. pmc Identification and pharmacological characterization of the anti-inflammatory principal of the leaves of dwarf elder (Sambucus ebulus L.)
    Stefan Schwaiger
    Institute of Pharmacy Pharmacognosy, University of Innsbruck, Josef Moeller Haus, Innrain 52c, A 6020 Innsbruck, Austria
    J Ethnopharmacol 133:704-9. 2011
    ..dwarf elder) in order to rationalize the traditional use of this plant for the treatment of chronically inflammatory diseases...
  19. ncbi request reprint Development and evaluation of an in vitro model for the analysis of cigarette smoke effects on cultured cells and tissues
    David Bernhard
    Institute for Pathophysiology, Medical University Innsbruck, Fritz Pregl Str 3, A 6020 Innsbruck, Austria
    J Pharmacol Toxicol Methods 50:45-51. 2004
    ..Although this conjunction is accepted knowledge, the basic biological mechanisms and the identities of the active tobacco smoke constituents surprisingly are still unknown. One reason for this is the lack of accurate in vitro models...
  20. doi request reprint Cigarette smoke extract induces prolonged endoplasmic reticulum stress and autophagic cell death in human umbilical vein endothelial cells
    Adam Csordas
    Division of Experimental Pathophysiology and Immunology, Laboratory of Autoimmunity, Biocenter, Innsbruck Medical University, Innsbruck, Austria
    Cardiovasc Res 92:141-8. 2011
    ....
  21. doi request reprint Cadmium is a novel and independent risk factor for early atherosclerosis mechanisms and in vivo relevance
    Barbara Messner
    Cardiac Surgery Research Laboratory, Department of Cardiac Surgery, Innsbruck Medical University, Austria
    Arterioscler Thromb Vasc Biol 29:1392-8. 2009
    ..Although cadmium (Cd) is an important and common environmental pollutant and has been linked to cardiovascular diseases, little is known about its effects in initial stages of atherosclerosis...
  22. ncbi request reprint Hydrogen peroxide-mediated necrosis induction in HUVECs is associated with an atypical pattern of caspase-3 cleavage
    Adam Csordas
    Vascular Biology Group, Division of Experimental Pathophysiology and Immunology, Innsbruck Biocenter, Innsbruck Medical University, Fritz Pregl Str 3, 6020 Innsbruck, Austria
    Exp Cell Res 312:1753-64. 2006
    ..Thus, the pattern of caspase-3 cleavage might reflect the proteolytic system engaged in the cell death machinery in HUVECs...
  23. pmc Serum concentration of integrin-linked kinase in malignant pleural mesothelioma and after asbestos exposure
    Stefan B Watzka
    Division of Thoracic Surgery, Otto Wagner Hospital, Vienna, Austria
    Eur J Cardiothorac Surg 43:940-5. 2013
    ..This study aimed to investigate whether serum ILK concentration could also be used to discriminate between MPM and asbestos exposure only...
  24. doi request reprint Cadmium activates a programmed, lysosomal membrane permeabilization-dependent necrosis pathway
    Barbara Messner
    Surgical Research Laboratories Cardiac Surgery, Department of Surgery, Medical University of Vienna, Vienna, Austria
    Toxicol Lett 212:268-75. 2012
    ..Importantly, lentivirus-based over-expression of the anti-apoptotic protein BCL-XL abrogates lysosomal rupture, DNA degradation and LDH release, clearly indicating that Cd induces a programmed form of cell death with a necrotic endpoint...
  25. doi request reprint Cadmium and cardiovascular diseases: cell biology, pathophysiology, and epidemiological relevance
    Barbara Messner
    Cardiothoracic Surgery, Research Laboratories, Department of Surgery, Medical University of Vienna, Wahringer Gurtel 18 20, Vienna, Austria
    Biometals 23:811-22. 2010
    ....
  26. doi request reprint Cardiovascular risk factors and atherosclerosis in young women: atherosclerosis risk factors in female youngsters (ARFY study)
    Michael Knoflach
    Department of Clinical Neurology, Innsbruck Medical University, Innsbruck, Austria
    Stroke 40:1063-9. 2009
    ..Little research has been conducted into risk factors of atherosclerosis development in young women...
  27. ncbi request reprint Metals in cigarette smoke
    David Bernhard
    Vascular Biology Group, Division of Experimental Pathophysiology and Immunology, Innsbruck Medical University, Austria
    IUBMB Life 57:805-9. 2005
    ..The metal content of tobacco plants, smoke, the circulation, and various organs is discussed. Finally, we link individual cigarette smoke contained metals to the genesis of human diseases...
  28. doi request reprint The elderly patient and cardiac surgery - a mini-review
    Dominik Wiedemann
    University Clinic of Cardiac Surgery, Innsbruck Medical University, Austria
    Gerontology 56:241-9. 2010
    ..Currently, coronary artery bypass surgery, aortic and mitral valve surgery and surgery of the ascending aorta are performed in elderly patients...
  29. pmc Leoligin, the major lignan from Edelweiss, activates cholesteryl ester transfer protein
    Kristina Duwensee
    Department of Internal Medicine I, Innsbruck Medical University, Innsbruck, Austria
    Atherosclerosis 219:109-15. 2011
    ..Cholesteryl ester transfer protein (CETP) plays a central role in the metabolism of high-density lipoprotein particles. Therefore, we searched for new drugs that bind to CETP and modulate its activity...
  30. ncbi request reprint Disruption of vascular endothelial homeostasis by tobacco smoke: impact on atherosclerosis
    David Bernhard
    Institute for Biomedical Aging Research, Austrian Academy of Sciences, Innsbruck, Austria
    FASEB J 17:2302-4. 2003
    ..Further, the endothelium could be rescued by changing to fresh medium even at times when the extracts had lost their activity. Finally, we show that N-acetyl cysteine and statins inhibit the adverse tobacco smoke effects...
  31. doi request reprint Detection of integrin-linked kinase in the serum of patients with malignant pleural mesothelioma
    Stefan B Watzka
    Division of Thoracic Surgery, Karl Landsteiner Institute for Thoracic Oncology, Otto Wagner Hospital, Vienna, Austria
    J Thorac Cardiovasc Surg 142:384-9. 2011
    ..This study asks whether integrin-linked kinase can also be detected in serum of patients with malignant pleural mesothelioma and whether serum level has diagnostic or prognostic relevance for that disease...
  32. pmc The combined use of known antiviral reverse transcriptase inhibitors AZT and DDI induce anticancer effects at low concentrations
    Thomas Aschacher
    Department of Surgery, Medical University of Vienna, Vienna, Austria
    Neoplasia 14:44-53. 2012
    ..This antiproliferative activity of the combined use of AZT and ddI at low, clinically applicable concentrations warrants clinical testing in human solid cancer...
  33. doi request reprint Cannabinoids lead to enhanced virulence of the smallpox vaccine (vaccinia) virus
    Hartwig P Huemer
    Dept of Hygiene, Microbiology and Social Medicine, Innsbruck Medical University, Austria
    Immunobiology 216:670-7. 2011
    ....
  34. ncbi request reprint Enhanced MTT-reducing activity under growth inhibition by resveratrol in CEM-C7H2 lymphocytic leukemia cells
    David Bernhard
    Tyrolean Cancer Research Institute, Innrain 66, A 6020 Innsbruck, Austria
    Cancer Lett 195:193-9. 2003
    ..Thus, in determining the effects of flavonoids and polyphenols on proliferation, in certain cell types this might represent a pitfall in the MTT proliferation assay...
  35. ncbi request reprint Anti-HSP60 immunity is already associated with atherosclerosis early in life
    M Knoflach
    Division of Experimental Pathophysiology and Immunology, Biocenter, Innsbruck Medical University, Fritz Pregl Strasse 3 IV, 6020 Innsbruck, Austria
    Ann N Y Acad Sci 1051:323-31. 2005
    ..Finally, we provide initial evidence that smoking, as the most important risk factor for atherogenesis, also exerts its disease-inducing and disease-promoting effects by inducing HSP60 expression by vascular endothelial cells...
  36. ncbi request reprint Stressful death of T-ALL tumor cells after treatment with the anti-tumor agent Tetrocarcin-A
    Inge Tinhofer
    Laboratory of Molecular Cytology, Department of Internal Medicine, University of Innsbruck, A 6020 Innsbruck, Austria
    FASEB J 16:1295-7. 2002
    ....