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Genomes and Genes | Peter HolzerSummaryCountry: Austria Publications
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Publications
Non-analgesic effects of opioids: management of opioid-induced constipation by peripheral opioid receptor antagonists: prevention or withdrawal?Peter Holzer
Research Unit of Translational Neurogastroenterology, Institute of Experimental and Clinical Pharmacology, Medical University of Graz, Austria
Curr Pharm Des 18:6010-20. 2012..g., urinary retention and pruritus). The continuous dosing of a PORA has the advantage of few adverse effects, while intermittent dosing of a PORA can be associated with abdominal cramp-like pain...
Neuropeptide Y, peptide YY and pancreatic polypeptide in the gut-brain axisPeter Holzer
Research Unit of Translational Neurogastroenterology, Institute of Experimental and Clinical Pharmacology, Medical University of Graz, Universitatsplatz 4, A 8010 Graz, Austria
Neuropeptides 46:261-74. 2012..These findings underscore the important role of the NPY-Y receptor system at several levels of the gut-brain axis in which NPY, PYY and PP operate both as neural and endocrine messengers...- Acid sensing by visceral afferent neuronesP Holzer
Institute of Experimental and Clinical Pharmacology, Medical University of Graz, Austria
Acta Physiol (Oxf) 201:63-75. 2011..As upregulation and overactivity of acid sensors appear to contribute to various forms of chronic inflammation and pain, acid-sensitive ion channels and receptors are also considered as targets for novel therapeutics... - Transient receptor potential (TRP) channels as drug targets for diseases of the digestive systemPeter Holzer
Research Unit of Translational Neurogastroenterology, Institute of Experimental and Clinical Pharmacology, Medical University of Graz, Universitatsplatz 4, A 8010 Graz, Austria
Pharmacol Ther 131:142-70. 2011..As a result, major efforts are put into the development of selective TRP channel agonists and antagonists and the assessment of their therapeutic potential... - Opioid receptors in the gastrointestinal tractPeter Holzer
Research Unit of Translational Neurogastroenterology, Institute of Experimental and Clinical Pharmacology, Medical University of Graz, Universitatsplatz 4, A 8010 Graz, Austria
Regul Pept 155:11-7. 2009..Preliminary evidence indicates that peripherally restricted opioid receptor antagonists may act as prokinetic drugs in their own right... 
Opioid antagonists for prevention and treatment of opioid-induced gastrointestinal effectsPeter Holzer
Research Unit of Translational Neurogastroenterology, Institute of Experimental and Clinical Pharmacology, Medical University of Graz, Graz, Austria
Curr Opin Anaesthesiol 23:616-22. 2010..This review highlights recent advances in the specific control of opioid-induced constipation by opioid receptor antagonists with limited systemic bioavailability or a peripherally restricted site of action...- TRP channels in the digestive systemPeter Holzer
Research Unit of Translational Neurogastroenterology, Institute of Experimental and Clinical Pharmacology, Medical University of Graz, Universitatsplatz 4, A 8010 Graz, Austria
Curr Pharm Biotechnol 12:24-34. 2011..Consequently, blockers of these TRP channels have been developed, and their clinical usefulness has yet to be established... - Pharmacology of inflammatory pain: local alteration in receptors and mediatorsPeter Holzer
Research Unit of Translational Neurogastroenterology, Institute for Experimental and Clinical Pharmacology, Medical University of Graz, Graz, Austria
Dig Dis 27:24-30. 2009.... - Sex-dependent control of murine emotional-affective behaviour in health and colitis by peptide YY and neuropeptide YEvelin Painsipp
Research Unit of Translational Neurogastroenterology, Institute of Experimental and Clinical Pharmacology, Medical University of Graz, Graz, Austria
Br J Pharmacol 163:1302-14. 2011..Because gastrointestinal inflammation is known to enhance anxiety, we explored whether experimental colitis interacts with genetic deletion (knockout) of PYY and NPY to alter emotional-affective behaviour... - Evidence from knockout mice that neuropeptide-Y Y2 and Y4 receptor signalling prevents long-term depression-like behaviour caused by immune challengeEvelin Painsipp
Research Unit of Translational Neurogastroenterology, Institute of Experimental and Clinical Pharmacology, Medical University of Graz, Graz, Austria
J Psychopharmacol 24:1551-60. 2010..These findings suggest that neuropeptide Y acting via Y2 and Y4 receptors prevents the development of long-term anxiety- and depression-like behaviour caused by acute immune challenge... - Evidence from knockout mice that peptide YY and neuropeptide Y enforce murine locomotion, exploration and ingestive behaviour in a circadian cycle- and gender-dependent mannerMartin E Edelsbrunner
Research Unit of Translational Neurogastroenterology, Institute of Experimental and Clinical Pharmacology, Medical University of Graz, Universitatsplatz 4, A 8010 Graz, Austria
Behav Brain Res 203:97-107. 2009..In addition, they counteract the anorectic and antidipsogenic effects of immune challenge... - Afferent signalling from the acid-challenged rat stomach is inhibited and gastric acid elimination is enhanced by lafutidineMartin E Edelsbrunner
Institute of Experimental and Clinical Pharmacology, Medical University of Graz, Graz, Austria
BMC Gastroenterol 9:40. 2009..The present study investigated whether intragastric administration of lafutidine (10 and 30 mg/kg) modifies vagal afferent signalling, mucosal injury, intragastric acidity and gastric emptying after gastric acid challenge... - Deletion of the acid-sensing ion channel ASIC3 prevents gastritis-induced acid hyperresponsiveness of the stomach-brainstem axisThomas Wultsch
Research Unit of Translational Neurogastroenterology, Institute of Experimental and Clinical Pharmacology, Medical University of Graz, Universitatsplatz 4, A 8010 Graz, Austria
Pain 134:245-53. 2008..The current data indicate that ASIC3 plays a major role in the acid hyperresponsiveness associated with experimental gastritis. In contrast, ASIC2 appears to dampen acid-evoked input from the stomach to the NTS... - Chemo-nociceptive signalling from the colon is enhanced by mild colitis and blocked by inhibition of transient receptor potential ankyrin 1 channelsMartina Mitrovic
Institute of Experimental and Clinical Pharmacology, Medical University of Graz, Graz, Austria
Br J Pharmacol 160:1430-42. 2010..Here we investigated whether intracolonic AITC causes afferent input to the spinal cord and whether this response is modified by mild colitis, morphine or a TRPA1 channel blocker... - Implication of neuropeptide-Y Y2 receptors in the effects of immune stress on emotional, locomotor and social behavior of miceEvelin Painsipp
Research Unit of Translational Neurogastroenterology, Institute of Experimental and Clinical Pharmacology, Medical University of Graz, Universitatsplatz 4, A 8010 Graz, Austria
Neuropharmacology 55:117-26. 2008..Our observations attest to an important role of endogenous NPY acting via Y2 receptors in the cerebral response to peripheral immune challenge... - Opioids and opioid receptors in the enteric nervous system: from a problem in opioid analgesia to a possible new prokinetic therapy in humansPeter Holzer
Department of Experimental and Clinical Pharmacology, Medical University of Graz, Universitatsplatz 4, A 8010 Graz, Austria
Neurosci Lett 361:192-5. 2004..There is emerging evidence that opioid receptor antagonists may also have prokinetic actions, reversing pathological states of gastrointestinal hypomotility that are due to overactivity of the enteric opioid system... - Taste receptors in the gastrointestinal tract. V. Acid sensing in the gastrointestinal tractPeter Holzer
Research Unit of Translational Neurogastroenterology, Department of Experimental and Clinical Pharmacology, Medical University of Graz, Graz, Austria
Am J Physiol Gastrointest Liver Physiol 292:G699-705. 2007..Some ionotropic purinoceptor ion channels and two-pore domain background K(+) channels are also sensitive to alterations of extracellular pH... - Gastrointestinal motility in acute illnessSonja Fruhwald
Department of Anesthesiology and Intensive Care Medicine, Medical University of Graz, Graz, Austria
Wien Klin Wochenschr 120:6-17. 2008..Generally effective methods to treat these conditions are given. Finally, we focus on special management options to prevent such motility disturbances or to reduce their severity... - Alosetron, cilansetron and tegaserod modify mesenteric but not colonic blood flow in ratsEvelin Painsipp
Research Unit of Translational Neurogastroenterology, Institute of Experimental and Clinical Pharmacology, Medical University of Graz, Graz, Austria
Br J Pharmacol 158:1210-26. 2009.... - Opioid-induced bowel dysfunction in cancer-related pain: causes, consequences, and a novel approach for its managementPeter Holzer
Institut fur Experimentelle und Klinische Pharmakologie, Medizinische Universitat Graz, Graz, Austria
J Opioid Manag 5:145-51. 2009..The combination has the potential to improve the quality of pain management significantly in these patients... - TRPV1 and the gut: from a tasty receptor for a painful vanilloid to a key player in hyperalgesiaPeter Holzer
Department of Experimental and Clinical Pharmacology, Medical University of Graz, Universitatsplatz 4, A 8010 Graz, Austria
Eur J Pharmacol 500:231-41. 2004.... - Prolonged depression-like behavior caused by immune challenge: influence of mouse strain and social environmentEvelin Painsipp
Research Unit of Translational Neurogastroenterology, Institute of Experimental and Clinical Pharmacology, Medical University of Graz, Graz, Austria
PLoS ONE 6:e20719. 2011..The discovery of an experimental model of long-term depression-like behavior after acute immune challenge is of relevance to the analysis of the epigenetic and pathophysiologic mechanisms of immune system-related affective disorders... - Treatment of opioid-induced gut dysfunctionPeter Holzer
Research Unit of Translational Neurogastroenterology, Institute of Experimental and Clinical Pharmacology, Medical University of Graz, Universitatsplatz 4, A 8010 Graz, Austria
Expert Opin Investig Drugs 16:181-94. 2007.... - Multidrug-resistance gene 1-type p-glycoprotein (MDR1 p-gp) inhibition by tariquidar impacts on neuroendocrine and behavioral processing of stressChristoph K Thoeringer
Research Unit of Translational Neurogastroenterology, Institute of Experimental and Clinical Pharmacology, Medical University of Graz, Graz 8010, Austria
Psychoneuroendocrinology 32:1028-40. 2007..These findings highlight a novel approach to the treatment of stress-related affective disorders in humans... - [Dementia and pain]Reinhold Schmidt
Universitätsklinik für Neurologie, Medizinische Universitat Graz
Neuropsychiatr 24:1-13. 2010..Multimodal pain therapy is superior to one-dimensional approaches. A discussion of the effects and interactions of the analgesics presently available for geriatric care forms an integral part of this review... - Immunocytochemical characterization of rat brainstem neurons with vagal afferent input from the stomach challenged by acid or ammoniaMarion Danzer
Department of Experimental and Clinical Pharmacology, University of Graz, , A-8010 Graz, Austria
Eur J Neurosci 19:85-92. 2004.... - Inhibition by female sex steroids of peristalsis in the guinea pig small intestineAkos Heinemann
Department of Experimental and Clinical Pharmacology, Karl Franzens University, Graz, Austria
Digestion 65:213-9. 2002..The effects of steroid hormones on propulsive peristalsis in the intestine were investigated in order to compare their adverse effect profile on this clinically most important motor pattern... - Environmental enrichment and gut inflammation modify stress-induced c-Fos expression in the mouse corticolimbic systemFlorian Reichmann
Research Unit of Translational Neurogastroenterology, Institute of Experimental and Clinical Pharmacology, Medical University of Graz, Graz, Austria
PLoS ONE 8:e54811. 2013.... - In vitro effect of bethanechol and suberyldicholine on regions of guinea pig esophagusRichard Ackbar
Experimental Fetal Surgery and Tissue Engineering Unit, Department of Pediatric and Adolescent Surgery, Medical University of Graz, Austria
J Surg Res 174:56-61. 2012..The aim of this study was to characterize the function of native esophageal tissue and determine differences in functional response to stimulation between anatomical sites... - TRPV1: a new target for treatment of visceral pain in IBS?Peter Holzer
Institute of Experimental and Clinical Pharmacology, Medical University of Graz, Universitatsplatz 4, A 8010 Graz, Austria
Gut 57:882-4. 2008 - Acid-sensitive ion channels in gastrointestinal functionPeter Holzer
Department of Experimental and Clinical Pharmacology, University of Graz, Universitatsplatz 4, A 8010 Graz, Austria
Curr Opin Pharmacol 3:618-25. 2003.... - Increased expression of TRPV1 receptor in dorsal root ganglia by acid insult of the rat gastric mucosaRudolf Schicho
Department of Experimental and Clinical Pharmacology, Medical University of Graz, Universitatsplatz 4, 8010 Graz, Austria
Eur J Neurosci 19:1811-8. 2004..The TRPV1 receptor may be a key molecule in the transduction of acid-induced nociception of the gastric mucosa and a mediator of visceral hypersensitivity... - Gastrointestinal pain in functional bowel disorders: sensory neurons as novel drug targetsPeter Holzer
Medical University of Graz, Department of Experimental and Clinical Pharmacology, Austria
Expert Opin Ther Targets 8:107-23. 2004..Particular therapeutic potential is attributed to targets that are selectively expressed by afferent neurons, such as the transient receptor potential channel TRPV1, acid-sensing ion channels and tetrodotoxin-resistant Na + channels... - Differential effects of intragastric acid and capsaicin on gastric emptying and afferent input to the rat spinal cord and brainstemPeter Holzer
Department of Experimental and Clinical Pharmacology, Medical University of Graz, Universitatsplatz 4, A 8010 Graz, Austria
BMC Neurosci 6:60. 2005.... - Efferent-like roles of afferent neurons in the gut: Blood flow regulation and tissue protectionPeter Holzer
Department of Experimental and Clinical Pharmacology, Medical University of Graz, Universitatsplatz 4, A 8010 Graz, Austria
Auton Neurosci 125:70-5. 2006..Thus, if GI pain is to be treated by sensory neuron-directed drugs it needs to be considered that these drugs do not inhibit nociception at the expense of GI mucosal vulnerability... - Role of visceral afferent neurons in mucosal inflammation and defensePeter Holzer
Research Unit of Translational Neurogastroenterology, Institute of Experimental and Clinical Pharmacology, Medical University of Graz, Universitatsplatz 4, A 8010 Graz, Austria
Curr Opin Pharmacol 7:563-9. 2007.... - Involvement of mu- and kappa-, but not delta-, opioid receptors in the peristaltic motor depression caused by endogenous and exogenous opioids in the guinea-pig intestineAnaid Shahbazian
Department of Experimental and Clinical Pharmacology, University of Graz, A 8010 Graz, Austria
Br J Pharmacol 135:741-50. 2002..The results show that the neural circuits controlling peristalsis in the guinea-pig small intestine are inhibited by endogenous and exogenous opioids acting via mu- and kappa-, but not delta-, opioid receptors... - Selective increase of dark phase water intake in neuropeptide-Y Y2 and Y4 receptor knockout miceThomas Wultsch
Department of Experimental and Clinical Pharmacology, Medical University of Graz, Universitatsplatz 4, A 8010 Graz, Austria
Behav Brain Res 168:255-60. 2006.... - Intestinal motility disturbances in intensive care patients pathogenesis and clinical impactSonja Fruhwald
Department of Anesthesiology and Intensive Care Medicine, Medical University of Graz, Auenbruggerplatz 29, 8036, Graz, Austria
Intensive Care Med 33:36-44. 2007..This review focuses on the pathophysiological basis of intestinal motility, the major patterns of pathological motility alterations, the impact on patient outcome, and current therapeutic options...