Peter Holzer

Summary

Country: Austria

Publications

  1. ncbi request reprint Neuropeptides and the microbiota-gut-brain axis
    Peter Holzer
    Research Unit of Translational Neurogastroenterology, Institute of Experimental and Clinical Pharmacology, Medical University of Graz, Universitatsplatz 4, 8010, Graz, Austria
    Adv Exp Med Biol 817:195-219. 2014
  2. pmc Prolonged depression-like behavior caused by immune challenge: influence of mouse strain and social environment
    Evelin Painsipp
    Research Unit of Translational Neurogastroenterology, Institute of Experimental and Clinical Pharmacology, Medical University of Graz, Graz, Austria
    PLoS ONE 6:e20719. 2011
  3. ncbi request reprint Non-analgesic effects of opioids: management of opioid-induced constipation by peripheral opioid receptor antagonists: prevention or withdrawal?
    Peter Holzer
    Research Unit of Translational Neurogastroenterology, Institute of Experimental and Clinical Pharmacology, Medical University of Graz, Austria
    Curr Pharm Des 18:6010-20. 2012
  4. pmc Neuropeptide Y, peptide YY and pancreatic polypeptide in the gut-brain axis
    Peter Holzer
    Research Unit of Translational Neurogastroenterology, Institute of Experimental and Clinical Pharmacology, Medical University of Graz, Universitatsplatz 4, A 8010 Graz, Austria
    Neuropeptides 46:261-74. 2012
  5. pmc Opioid receptors in the gastrointestinal tract
    Peter Holzer
    Research Unit of Translational Neurogastroenterology, Institute of Experimental and Clinical Pharmacology, Medical University of Graz, Universitatsplatz 4, A 8010 Graz, Austria
    Regul Pept 155:11-7. 2009
  6. pmc TRP channels in the digestive system
    Peter Holzer
    Research Unit of Translational Neurogastroenterology, Institute of Experimental and Clinical Pharmacology, Medical University of Graz, Universitatsplatz 4, A 8010 Graz, Austria
    Curr Pharm Biotechnol 12:24-34. 2011
  7. pmc Transient receptor potential (TRP) channels as drug targets for diseases of the digestive system
    Peter Holzer
    Research Unit of Translational Neurogastroenterology, Institute of Experimental and Clinical Pharmacology, Medical University of Graz, Universitatsplatz 4, A 8010 Graz, Austria
    Pharmacol Ther 131:142-70. 2011
  8. doi request reprint Pharmacology of inflammatory pain: local alteration in receptors and mediators
    Peter Holzer
    Research Unit of Translational Neurogastroenterology, Institute for Experimental and Clinical Pharmacology, Medical University of Graz, Graz, Austria
    Dig Dis 27:24-30. 2009
  9. pmc Acid sensing by visceral afferent neurones
    P Holzer
    Institute of Experimental and Clinical Pharmacology, Medical University of Graz, Austria
    Acta Physiol (Oxf) 201:63-75. 2011
  10. doi request reprint Opioid antagonists for prevention and treatment of opioid-induced gastrointestinal effects
    Peter Holzer
    Research Unit of Translational Neurogastroenterology, Institute of Experimental and Clinical Pharmacology, Medical University of Graz, Graz, Austria
    Curr Opin Anaesthesiol 23:616-22. 2010

Collaborators

Detail Information

Publications45

  1. ncbi request reprint Neuropeptides and the microbiota-gut-brain axis
    Peter Holzer
    Research Unit of Translational Neurogastroenterology, Institute of Experimental and Clinical Pharmacology, Medical University of Graz, Universitatsplatz 4, 8010, Graz, Austria
    Adv Exp Med Biol 817:195-219. 2014
    ....
  2. pmc Prolonged depression-like behavior caused by immune challenge: influence of mouse strain and social environment
    Evelin Painsipp
    Research Unit of Translational Neurogastroenterology, Institute of Experimental and Clinical Pharmacology, Medical University of Graz, Graz, Austria
    PLoS ONE 6:e20719. 2011
    ..The discovery of an experimental model of long-term depression-like behavior after acute immune challenge is of relevance to the analysis of the epigenetic and pathophysiologic mechanisms of immune system-related affective disorders...
  3. ncbi request reprint Non-analgesic effects of opioids: management of opioid-induced constipation by peripheral opioid receptor antagonists: prevention or withdrawal?
    Peter Holzer
    Research Unit of Translational Neurogastroenterology, Institute of Experimental and Clinical Pharmacology, Medical University of Graz, Austria
    Curr Pharm Des 18:6010-20. 2012
    ..g., urinary retention and pruritus). The continuous dosing of a PORA has the advantage of few adverse effects, while intermittent dosing of a PORA can be associated with abdominal cramp-like pain...
  4. pmc Neuropeptide Y, peptide YY and pancreatic polypeptide in the gut-brain axis
    Peter Holzer
    Research Unit of Translational Neurogastroenterology, Institute of Experimental and Clinical Pharmacology, Medical University of Graz, Universitatsplatz 4, A 8010 Graz, Austria
    Neuropeptides 46:261-74. 2012
    ..These findings underscore the important role of the NPY-Y receptor system at several levels of the gut-brain axis in which NPY, PYY and PP operate both as neural and endocrine messengers...
  5. pmc Opioid receptors in the gastrointestinal tract
    Peter Holzer
    Research Unit of Translational Neurogastroenterology, Institute of Experimental and Clinical Pharmacology, Medical University of Graz, Universitatsplatz 4, A 8010 Graz, Austria
    Regul Pept 155:11-7. 2009
    ..Preliminary evidence indicates that peripherally restricted opioid receptor antagonists may act as prokinetic drugs in their own right...
  6. pmc TRP channels in the digestive system
    Peter Holzer
    Research Unit of Translational Neurogastroenterology, Institute of Experimental and Clinical Pharmacology, Medical University of Graz, Universitatsplatz 4, A 8010 Graz, Austria
    Curr Pharm Biotechnol 12:24-34. 2011
    ..Consequently, blockers of these TRP channels have been developed, and their clinical usefulness has yet to be established...
  7. pmc Transient receptor potential (TRP) channels as drug targets for diseases of the digestive system
    Peter Holzer
    Research Unit of Translational Neurogastroenterology, Institute of Experimental and Clinical Pharmacology, Medical University of Graz, Universitatsplatz 4, A 8010 Graz, Austria
    Pharmacol Ther 131:142-70. 2011
    ..As a result, major efforts are put into the development of selective TRP channel agonists and antagonists and the assessment of their therapeutic potential...
  8. doi request reprint Pharmacology of inflammatory pain: local alteration in receptors and mediators
    Peter Holzer
    Research Unit of Translational Neurogastroenterology, Institute for Experimental and Clinical Pharmacology, Medical University of Graz, Graz, Austria
    Dig Dis 27:24-30. 2009
    ..Basically, all primary afferent neurons supplying the gut can be sensitized in response to pro-inflammatory mediators, and the mechanisms whereby hypersensitivity is initiated and maintained are, thus, of prime therapeutic interest...
  9. pmc Acid sensing by visceral afferent neurones
    P Holzer
    Institute of Experimental and Clinical Pharmacology, Medical University of Graz, Austria
    Acta Physiol (Oxf) 201:63-75. 2011
    ..As upregulation and overactivity of acid sensors appear to contribute to various forms of chronic inflammation and pain, acid-sensitive ion channels and receptors are also considered as targets for novel therapeutics...
  10. doi request reprint Opioid antagonists for prevention and treatment of opioid-induced gastrointestinal effects
    Peter Holzer
    Research Unit of Translational Neurogastroenterology, Institute of Experimental and Clinical Pharmacology, Medical University of Graz, Graz, Austria
    Curr Opin Anaesthesiol 23:616-22. 2010
    ..This review highlights recent advances in the specific control of opioid-induced constipation by opioid receptor antagonists with limited systemic bioavailability or a peripherally restricted site of action...
  11. doi request reprint Evidence from knockout mice that peptide YY and neuropeptide Y enforce murine locomotion, exploration and ingestive behaviour in a circadian cycle- and gender-dependent manner
    Martin E Edelsbrunner
    Research Unit of Translational Neurogastroenterology, Institute of Experimental and Clinical Pharmacology, Medical University of Graz, Universitatsplatz 4, A 8010 Graz, Austria
    Behav Brain Res 203:97-107. 2009
    ..In addition, they counteract the anorectic and antidipsogenic effects of immune challenge...
  12. pmc Sex-dependent control of murine emotional-affective behaviour in health and colitis by peptide YY and neuropeptide Y
    Evelin Painsipp
    Research Unit of Translational Neurogastroenterology, Institute of Experimental and Clinical Pharmacology, Medical University of Graz, Graz, Austria
    Br J Pharmacol 163:1302-14. 2011
    ..Because gastrointestinal inflammation is known to enhance anxiety, we explored whether experimental colitis interacts with genetic deletion (knockout) of PYY and NPY to alter emotional-affective behaviour...
  13. doi request reprint Evidence from knockout mice that neuropeptide-Y Y2 and Y4 receptor signalling prevents long-term depression-like behaviour caused by immune challenge
    Evelin Painsipp
    Research Unit of Translational Neurogastroenterology, Institute of Experimental and Clinical Pharmacology, Medical University of Graz, Graz, Austria
    J Psychopharmacol 24:1551-60. 2010
    ..These findings suggest that neuropeptide Y acting via Y2 and Y4 receptors prevents the development of long-term anxiety- and depression-like behaviour caused by acute immune challenge...
  14. ncbi request reprint Deletion of the acid-sensing ion channel ASIC3 prevents gastritis-induced acid hyperresponsiveness of the stomach-brainstem axis
    Thomas Wultsch
    Research Unit of Translational Neurogastroenterology, Institute of Experimental and Clinical Pharmacology, Medical University of Graz, Universitatsplatz 4, A 8010 Graz, Austria
    Pain 134:245-53. 2008
    ..The current data indicate that ASIC3 plays a major role in the acid hyperresponsiveness associated with experimental gastritis. In contrast, ASIC2 appears to dampen acid-evoked input from the stomach to the NTS...
  15. pmc Afferent signalling from the acid-challenged rat stomach is inhibited and gastric acid elimination is enhanced by lafutidine
    Martin E Edelsbrunner
    Institute of Experimental and Clinical Pharmacology, Medical University of Graz, Graz, Austria
    BMC Gastroenterol 9:40. 2009
    ..The present study investigated whether intragastric administration of lafutidine (10 and 30 mg/kg) modifies vagal afferent signalling, mucosal injury, intragastric acidity and gastric emptying after gastric acid challenge...
  16. pmc Chemo-nociceptive signalling from the colon is enhanced by mild colitis and blocked by inhibition of transient receptor potential ankyrin 1 channels
    Martina Mitrovic
    Institute of Experimental and Clinical Pharmacology, Medical University of Graz, Graz, Austria
    Br J Pharmacol 160:1430-42. 2010
    ..Here we investigated whether intracolonic AITC causes afferent input to the spinal cord and whether this response is modified by mild colitis, morphine or a TRPA1 channel blocker...
  17. doi request reprint Implication of neuropeptide-Y Y2 receptors in the effects of immune stress on emotional, locomotor and social behavior of mice
    Evelin Painsipp
    Research Unit of Translational Neurogastroenterology, Institute of Experimental and Clinical Pharmacology, Medical University of Graz, Universitatsplatz 4, A 8010 Graz, Austria
    Neuropharmacology 55:117-26. 2008
    ..Our observations attest to an important role of endogenous NPY acting via Y2 receptors in the cerebral response to peripheral immune challenge...
  18. ncbi request reprint Immunocytochemical characterization of rat brainstem neurons with vagal afferent input from the stomach challenged by acid or ammonia
    Marion Danzer
    Department of Experimental and Clinical Pharmacology, University of Graz, Universitatsplatz 4, A 8010 Graz, Austria
    Eur J Neurosci 19:85-92. 2004
    ....
  19. ncbi request reprint Taste receptors in the gastrointestinal tract. V. Acid sensing in the gastrointestinal tract
    Peter Holzer
    Research Unit of Translational Neurogastroenterology, Department of Experimental and Clinical Pharmacology, Medical University of Graz, Graz, Austria
    Am J Physiol Gastrointest Liver Physiol 292:G699-705. 2007
    ..Some ionotropic purinoceptor ion channels and two-pore domain background K(+) channels are also sensitive to alterations of extracellular pH...
  20. ncbi request reprint Opioids and opioid receptors in the enteric nervous system: from a problem in opioid analgesia to a possible new prokinetic therapy in humans
    Peter Holzer
    Department of Experimental and Clinical Pharmacology, Medical University of Graz, Universitatsplatz 4, A 8010 Graz, Austria
    Neurosci Lett 361:192-5. 2004
    ..There is emerging evidence that opioid receptor antagonists may also have prokinetic actions, reversing pathological states of gastrointestinal hypomotility that are due to overactivity of the enteric opioid system...
  21. pmc Environmental enrichment and gut inflammation modify stress-induced c-Fos expression in the mouse corticolimbic system
    Florian Reichmann
    Research Unit of Translational Neurogastroenterology, Institute of Experimental and Clinical Pharmacology, Medical University of Graz, Graz, Austria
    PLoS ONE 8:e54811. 2013
    ....
  22. ncbi request reprint Evaluation of peristalsis in multiple segments of the guinea-pig isolated small intestine: optimisation of tissue use by refined in vitro methodology
    Peter Holzer
    Department of Experimental and Clinical Pharmacology, University of Graz, Universitatsplatz 4, 8010 Graz, Austria
    Altern Lab Anim 31:419-27. 2003
    ..This system promises to be particularly useful in the pharmacological screening and testing of drugs which modify peristalsis...
  23. pmc Differential effects of intragastric acid and capsaicin on gastric emptying and afferent input to the rat spinal cord and brainstem
    Peter Holzer
    Department of Experimental and Clinical Pharmacology, Medical University of Graz, Universitatsplatz 4, A 8010 Graz, Austria
    BMC Neurosci 6:60. 2005
    ....
  24. doi request reprint Gastrointestinal motility in acute illness
    Sonja Fruhwald
    Department of Anesthesiology and Intensive Care Medicine, Medical University of Graz, Graz, Austria
    Wien Klin Wochenschr 120:6-17. 2008
    ..Generally effective methods to treat these conditions are given. Finally, we focus on special management options to prevent such motility disturbances or to reduce their severity...
  25. ncbi request reprint Multidrug-resistance gene 1-type p-glycoprotein (MDR1 p-gp) inhibition by tariquidar impacts on neuroendocrine and behavioral processing of stress
    Christoph K Thoeringer
    Research Unit of Translational Neurogastroenterology, Institute of Experimental and Clinical Pharmacology, Medical University of Graz, Graz 8010, Austria
    Psychoneuroendocrinology 32:1028-40. 2007
    ..These findings highlight a novel approach to the treatment of stress-related affective disorders in humans...
  26. doi request reprint Neuropeptide Y and peptide YY protect from weight loss caused by Bacille Calmette-Guérin in mice
    Evelin Painsipp
    Research Unit of Translational Neurogastroenterology, Institute of Experimental and Clinical Pharmacology, Medical University of Graz, Graz, Austria
    Br J Pharmacol 170:1014-26. 2013
    ..Because neuropeptide Y (NPY) and peptide YY (PYY) are involved in the regulation of food intake, we hypothesized that they play a role in the BCG-induced weight loss...
  27. ncbi request reprint Increased expression of TRPV1 receptor in dorsal root ganglia by acid insult of the rat gastric mucosa
    Rudolf Schicho
    Department of Experimental and Clinical Pharmacology, Medical University of Graz, Universitatsplatz 4, 8010 Graz, Austria
    Eur J Neurosci 19:1811-8. 2004
    ..The TRPV1 receptor may be a key molecule in the transduction of acid-induced nociception of the gastric mucosa and a mediator of visceral hypersensitivity...
  28. pmc Differential peristaltic motor effects of prostanoid (DP, EP, IP, TP) and leukotriene receptor agonists in the guinea-pig isolated small intestine
    Anaid Shahbazian
    Department of Experimental and Clinical Pharmacology, University of Graz, A 8010 Graz, Austria
    Br J Pharmacol 137:1047-54. 2002
    ..In a wider perspective it appears as if the effect of prostanoid receptor agonists to induce diarrhoea is due to their prosecretory but not peristaltic motor action...
  29. pmc Alosetron, cilansetron and tegaserod modify mesenteric but not colonic blood flow in rats
    Evelin Painsipp
    Research Unit of Translational Neurogastroenterology, Institute of Experimental and Clinical Pharmacology, Medical University of Graz, Graz, Austria
    Br J Pharmacol 158:1210-26. 2009
    ....
  30. ncbi request reprint TRPV1 and the gut: from a tasty receptor for a painful vanilloid to a key player in hyperalgesia
    Peter Holzer
    Department of Experimental and Clinical Pharmacology, Medical University of Graz, Universitatsplatz 4, A 8010 Graz, Austria
    Eur J Pharmacol 500:231-41. 2004
    ....
  31. ncbi request reprint Opioid-induced bowel dysfunction in cancer-related pain: causes, consequences, and a novel approach for its management
    Peter Holzer
    Institut fur Experimentelle und Klinische Pharmakologie, Medizinische Universitat Graz, Graz, Austria
    J Opioid Manag 5:145-51. 2009
    ..The combination has the potential to improve the quality of pain management significantly in these patients...
  32. ncbi request reprint Treatment of opioid-induced gut dysfunction
    Peter Holzer
    Research Unit of Translational Neurogastroenterology, Institute of Experimental and Clinical Pharmacology, Medical University of Graz, Universitatsplatz 4, A 8010 Graz, Austria
    Expert Opin Investig Drugs 16:181-94. 2007
    ....
  33. ncbi request reprint [Dementia and pain]
    Reinhold Schmidt
    Universitätsklinik für Neurologie, Medizinische Universitat Graz
    Neuropsychiatr 24:1-13. 2010
    ..Multimodal pain therapy is superior to one-dimensional approaches. A discussion of the effects and interactions of the analgesics presently available for geriatric care forms an integral part of this review...
  34. pmc Myeloperoxidase-derived oxidants induce blood-brain barrier dysfunction in vitro and in vivo
    Andreas Ullen
    Institute of Molecular Biology and Biochemistry, Medical University of Graz, Austria
    PLoS ONE 8:e64034. 2013
    ..The current data provide evidence that interference with the MPO pathway could protect against BBB dysfunction under (neuro)inflammatory conditions...
  35. ncbi request reprint Role of visceral afferent neurons in mucosal inflammation and defense
    Peter Holzer
    Research Unit of Translational Neurogastroenterology, Institute of Experimental and Clinical Pharmacology, Medical University of Graz, Universitatsplatz 4, A 8010 Graz, Austria
    Curr Opin Pharmacol 7:563-9. 2007
    ....
  36. ncbi request reprint Inhibition by female sex steroids of peristalsis in the guinea pig small intestine
    Akos Heinemann
    Department of Experimental and Clinical Pharmacology, Karl Franzens University, Graz, Austria
    Digestion 65:213-9. 2002
    ..The effects of steroid hormones on propulsive peristalsis in the intestine were investigated in order to compare their adverse effect profile on this clinically most important motor pattern...
  37. ncbi request reprint Stomach-brain communication by vagal afferents in response to luminal acid backdiffusion, gastrin, and gastric acid secretion
    Marion Danzer
    Deartment of Experimental and Clinical Pharmacology, University of Graz, A 8010 Graz, Austria
    Am J Physiol Gastrointest Liver Physiol 286:G403-11. 2004
    ....
  38. ncbi request reprint Selective increase of dark phase water intake in neuropeptide-Y Y2 and Y4 receptor knockout mice
    Thomas Wultsch
    Department of Experimental and Clinical Pharmacology, Medical University of Graz, Universitatsplatz 4, A 8010 Graz, Austria
    Behav Brain Res 168:255-60. 2006
    ....
  39. doi request reprint In vitro effect of bethanechol and suberyldicholine on regions of guinea pig esophagus
    Richard Ackbar
    Experimental Fetal Surgery and Tissue Engineering Unit, Department of Pediatric and Adolescent Surgery, Medical University of Graz, Austria
    J Surg Res 174:56-61. 2012
    ..The aim of this study was to characterize the function of native esophageal tissue and determine differences in functional response to stimulation between anatomical sites...
  40. ncbi request reprint Acid-sensitive ion channels in gastrointestinal function
    Peter Holzer
    Department of Experimental and Clinical Pharmacology, University of Graz, Universitatsplatz 4, A 8010 Graz, Austria
    Curr Opin Pharmacol 3:618-25. 2003
    ....
  41. ncbi request reprint Gastrointestinal pain in functional bowel disorders: sensory neurons as novel drug targets
    Peter Holzer
    Medical University of Graz, Department of Experimental and Clinical Pharmacology, Austria
    Expert Opin Ther Targets 8:107-23. 2004
    ..Particular therapeutic potential is attributed to targets that are selectively expressed by afferent neurons, such as the transient receptor potential channel TRPV1, acid-sensing ion channels and tetrodotoxin-resistant Na + channels...
  42. ncbi request reprint Efferent-like roles of afferent neurons in the gut: Blood flow regulation and tissue protection
    Peter Holzer
    Department of Experimental and Clinical Pharmacology, Medical University of Graz, Universitatsplatz 4, A 8010 Graz, Austria
    Auton Neurosci 125:70-5. 2006
    ..Thus, if GI pain is to be treated by sensory neuron-directed drugs it needs to be considered that these drugs do not inhibit nociception at the expense of GI mucosal vulnerability...
  43. ncbi request reprint TRPV1: a new target for treatment of visceral pain in IBS?
    Peter Holzer
    Institute of Experimental and Clinical Pharmacology, Medical University of Graz, Universitatsplatz 4, A 8010 Graz, Austria
    Gut 57:882-4. 2008
  44. pmc Involvement of mu- and kappa-, but not delta-, opioid receptors in the peristaltic motor depression caused by endogenous and exogenous opioids in the guinea-pig intestine
    Anaid Shahbazian
    Department of Experimental and Clinical Pharmacology, University of Graz, A 8010 Graz, Austria
    Br J Pharmacol 135:741-50. 2002
    ..The results show that the neural circuits controlling peristalsis in the guinea-pig small intestine are inhibited by endogenous and exogenous opioids acting via mu- and kappa-, but not delta-, opioid receptors...
  45. ncbi request reprint Intestinal motility disturbances in intensive care patients pathogenesis and clinical impact
    Sonja Fruhwald
    Department of Anesthesiology and Intensive Care Medicine, Medical University of Graz, Auenbruggerplatz 29, 8036, Graz, Austria
    Intensive Care Med 33:36-44. 2007
    ..This review focuses on the pathophysiological basis of intestinal motility, the major patterns of pathological motility alterations, the impact on patient outcome, and current therapeutic options...