Research Topics
| A FestaSummaryCountry: Austria Publications
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Publications
Chronic subclinical inflammation as part of the insulin resistance syndrome: the Insulin Resistance Atherosclerosis Study (IRAS)A Festa
Department of Medicine, University of Texas Health Science Center at San Antonio, 78228 3900, USA
Circulation 102:42-7. 2000..Recently, some components of the insulin resistance syndrome (IRS) have been related to inflammatory markers. We hypothesized that insulin insensitivity, as directly measured, may be associated with inflammation in nondiabetic subjects...
Small, dense low density lipoprotein (LDL) and the insulin resistance syndrome (IRS)A Festa
Department of Medicine 1, Rudolfstiftung Hospital, Vienna, Austria
Clin Lab 47:111-8. 2001..Randomized controlled trials investigating the effect of these therapies not only on LDL size but also on clinical (cardiovascular) endpoints will be of particular interest...
The relation of body fat mass and distribution to markers of chronic inflammationA Festa
Department of Medicine, Division of Clinical Epidemiology, University of Texas Health Science Center at San Antonio, Texas, USA
Int J Obes Relat Metab Disord 25:1407-15. 2001..These associations were not explained by lower S(I) in obese subjects. Chronic, subclinical inflammation may be one pathophysiological mechanism explaining the increased risk of atherosclerotic disease associated with adiposity...
Relative contribution of insulin and its precursors to fibrinogen and PAI-1 in a large population with different states of glucose tolerance. The Insulin Resistance Atherosclerosis Study (IRAS)A Festa
Department of Medicine, Division of Clinical Epidemiology, University of Texas Health Science Center at San Antonio, TX 78284 7873, USA
Arterioscler Thromb Vasc Biol 19:562-8. 1999..These findings may have important clinical implications in the risk assessment and prevention of macrovascular disease, not only in patients with overt diabetes but also in nondiabetic subjects who are hyperinsulinemic...
Low-density lipoprotein particle size is inversely related to plasminogen activator inhibitor-1 levels. The Insulin Resistance Atherosclerosis StudyA Festa
Department of Medicine, Division of Clinical Epidemiology, University of Texas Health Science Center at San Antonio, TX, USA
Arterioscler Thromb Vasc Biol 19:605-10. 1999..The demonstrated inverse relation of LDL size and PAI-1 levels provides one possible explanation for the atherogeneity of small dense LDL particles...
Relative hypoleptinaemia in women with mild gestational diabetes mellitusA Festa
Department of Medicine, University of Texas Health Science Center at San Antonio, 78284 7873, USA
Diabet Med 16:656-62. 1999..Leptin is synthesized in the human placenta. The aim of this study was to relate serum leptin levels during pregnancy to glucose tolerance, body mass index (BMI) and specific metabolic variables, such as specific insulin and proinsulin...
Is QT interval a marker of subclinical atherosclerosis in nondiabetic subjects? The Insulin Resistance Atherosclerosis Study (IRAS)A Festa
Department of Medicine, Division of Clinical Epidemiology, University of Texas Health Science Center at San Antonio, USA
Stroke 30:1566-71. 1999..Prolonged heart rate-corrected QT interval is an unfavorable prognostic factor of cardiovascular morbidity and mortality, and QT interval prolongation may be the result of atherosclerosis...
Trp64Arg polymorphism of the beta3-adrenergic receptor gene in pregnancy: association with mild gestational diabetes mellitusA Festa
Department of Medicine, University of Texas Health Science Center, San Antonio 78284 7873, USA
J Clin Endocrinol Metab 84:1695-9. 1999..The association with mild gestational diabetes suggests that the impact of the polymorphism may be clinically important during pregnancy, a state of physiological insulin resistance...
Insulin-resistant prediabetic subjects have more atherogenic risk factors than insulin-sensitive prediabetic subjects: implications for preventing coronary heart disease during the prediabetic stateS M Haffner
Division of Clinical Epidemiology, Department of Medicine, University of Texas Health Science Center at San Antonio, 78284 7873, USA
Circulation 101:975-80. 2000..However, it is not known whether these atherogenic changes in the prediabetic state are predominantly due to insulin resistance, decreased insulin secretion, or both...
A serine/alanine polymorphism in the nucleotide-binding fold-2 of the sulphonylurea receptor-1 (S1369A) is associated with enhanced glucose-induced insulin secretion during pregnancyW Krugluger
Institute of Clinical Chemistry, Municipal Hospital Rudolfstiftung, Vienna, Austria
J Inherit Metab Dis 23:705-12. 2000..01, p=0.9). From our data we conclude that in PW with the alanine substitution in the NBF-2 region, the insulin response of the pancreatic beta-cell after glucose intake is enhanced and does not correlate with actual BG levels...
Low levels of Sex-Hormone-Binding Globulin predict insulin requirement in patients with gestational diabetes mellitusH P Kopp
Department of Medicine 1, Rudolfstiftung Hospital, Juchgasse 25, A 1030 Vienna, Austria
Exp Clin Endocrinol Diabetes 109:365-9. 2001..30; p <0.01). In summary, we found significantly lower levels of SHBG in patients with GDM, especially in those who developed severe GDM and required insulin therapy during the last months of pregnancy...
C-reactive protein is more strongly related to post-glucose load glucose than to fasting glucose in non-diabetic subjects; the Insulin Resistance Atherosclerosis StudyA Festa
Department of Medicine, University of Texas Health Science Center at San Antonio, TX 78228-3900, USA
Diabet Med 19:939-43. 2002..This association is partially independent of body fat and insulin resistance...
Impact of weight loss on inflammatory proteins and their association with the insulin resistance syndrome in morbidly obese patientsH P Kopp
Department of Medicine 1, Rudolfstiftung Hospital, Juchgasse 25, A 1030 Vienna, Austria
Arterioscler Thromb Vasc Biol 23:1042-7. 2003..Elevated levels of C-reactive protein (CRP) and interleukin-6 (IL-6), indicating chronic subclinical inflammation, have been associated with features of the IRS and incident cardiovascular disease...
