Alexander J A Deutsch
- The nuclear orphan receptor NR4A1 and NR4A3 as tumor suppressors in hematologic neoplasmsKerstin Wenzl
Auenbruggerplatz 38, A 8036 Graz, Austria
Curr Drug Targets 16:38-46. 2015..Due to this fact and the growing number of NR4A1 and NR4A3 inducing agents and NR4A agonists, both receptors represent new targets for anti tumor therapy. ..
- Chemokine receptors in gastric MALT lymphoma: loss of CXCR4 and upregulation of CXCR7 is associated with progression to diffuse large B-cell lymphomaAlexander J A Deutsch
Division of Hematology, Department of Internal Medicine, Medical University Graz, Graz, Austria
Mod Pathol 26:182-94. 2013..Our data indicate that CXCR4 expression is associated with nodal manifestation and a more advanced stage of lymphomas and hence, might serve as useful clinical prognostic marker...
- The nuclear orphan receptors NR4A as therapeutic target in cancer therapyAlexander J A Deutsch
Division of Hematology, Department of Internal Medicine, Medical University Graz, Austria
Anticancer Agents Med Chem 12:1001-14. 2012..In particular, the recent identification of pro-apoptotic agents inducing NR4A expression or acting as agonists suggests that these members could serve as potential targets for cancer therapy...
- NR4A1-mediated apoptosis suppresses lymphomagenesis and is associated with a favorable cancer-specific survival in patients with aggressive B-cell lymphomasAlexander J A Deutsch
Division of Hematology, Department of Internal Medicine
Blood 123:2367-77. 2014..Our data suggest that NR4A1 has proapoptotic functions in aggressive lymphoma cells and define NR4A1 as a novel gene with tumor suppressor properties involved in lymphomagenesis...