Gerald Gartlehner

Summary

Affiliation: Danube University Krems
Country: Austria

Publications

  1. doi The general and comparative efficacy and safety of duloxetine in major depressive disorder: a systematic review and meta-analysis
    Gerald Gartlehner
    Department for Evidence based Medicine and Clinical Epidemiology, Danube University Krems, Krems, Austria
    Drug Saf 32:1159-73. 2009
  2. doi [Balancing benefits and harms of population-based interventions, using the example of cancer screening]
    Gerald Gartlehner
    Department für Evidenzbasierte Medizin und Klinische Epidemiologie, Donau Universität Krems Österreich
    Z Evid Fortbild Qual Gesundhwes 105:176-82. 2011
  3. doi Adjunct ultrasonography for breast cancer screening in women at average risk: a systematic review
    Gerald Gartlehner
    Department of Evidence Based Medicine and Clinical Epidemiology, Danube University, Krems, Austria
    Int J Evid Based Healthc 11:87-93. 2013
  4. doi Mammography in combination with breast ultrasonography versus mammography for breast cancer screening in women at average risk
    Gerald Gartlehner
    RTI International, Research Triangle Park, NC, USA
    Cochrane Database Syst Rev 4:CD009632. 2013
  5. doi How should primary care doctors select which antidepressants to administer?
    Gerald Gartlehner
    Department of Evidence Based Medicine and Clinical Epidemiology, Danube University, Karl Dorrek Strasse 30, 3500, Krems, Austria
    Curr Psychiatry Rep 14:360-9. 2012
  6. doi Clinical heterogeneity in systematic reviews and health technology assessments: synthesis of guidance documents and the literature
    Gerald Gartlehner
    Danube University, Krems
    Int J Technol Assess Health Care 28:36-43. 2012
  7. doi Comparative benefits and harms of second-generation antidepressants for treating major depressive disorder: an updated meta-analysis
    Gerald Gartlehner
    Danube University, Krems, Austria
    Ann Intern Med 155:772-85. 2011
  8. doi The effect of study sponsorship on a systematically evaluated body of evidence of head-to-head trials was modest: secondary analysis of a systematic review
    Gerald Gartlehner
    Department of Evidence Based Medicine and Clinical Epidemiology, Danube University, Krems, Austria
    J Clin Epidemiol 63:117-25. 2010
  9. doi Inadequate reporting of trials compromises the applicability of systematic reviews
    Gerald Gartlehner
    Department for Evidence based Medicine and Clinical Epidemiology, Danube University, Krems, Austria
    Int J Technol Assess Health Care 25:323-30. 2009
  10. ncbi Assessment of adverse effects and applicability--two areas not (yet) covered adequately in Cochrane reports
    Gerald Gartlehner
    Danube University, Krems, Austria
    Z Evid Fortbild Qual Gesundhwes 102:497-502. 2008

Collaborators

Detail Information

Publications29

  1. doi The general and comparative efficacy and safety of duloxetine in major depressive disorder: a systematic review and meta-analysis
    Gerald Gartlehner
    Department for Evidence based Medicine and Clinical Epidemiology, Danube University Krems, Krems, Austria
    Drug Saf 32:1159-73. 2009
    ..Second-generation antidepressants dominate the management of patients with major depressive disorder (MDD). Evidence on the general and comparative benefits and harms is still accruing...
  2. doi [Balancing benefits and harms of population-based interventions, using the example of cancer screening]
    Gerald Gartlehner
    Department für Evidenzbasierte Medizin und Klinische Epidemiologie, Donau Universität Krems Österreich
    Z Evid Fortbild Qual Gesundhwes 105:176-82. 2011
    ..Studies, however, indicate that the prerequisite for informed decision making, namely objective and balanced information about benefits and harms, is often missing...
  3. doi Adjunct ultrasonography for breast cancer screening in women at average risk: a systematic review
    Gerald Gartlehner
    Department of Evidence Based Medicine and Clinical Epidemiology, Danube University, Krems, Austria
    Int J Evid Based Healthc 11:87-93. 2013
    ..Critics are concerned that adjunct ultrasonography will also increase the rate of false-positive findings and can lead to unnecessary biopsies and treatments in women at average risk...
  4. doi Mammography in combination with breast ultrasonography versus mammography for breast cancer screening in women at average risk
    Gerald Gartlehner
    RTI International, Research Triangle Park, NC, USA
    Cochrane Database Syst Rev 4:CD009632. 2013
    ..Critics, however, are concerned that performing supplemental ultrasonography on women at average risk will also increase the rate of false positive findings and can lead to unnecessary biopsies and treatments...
  5. doi How should primary care doctors select which antidepressants to administer?
    Gerald Gartlehner
    Department of Evidence Based Medicine and Clinical Epidemiology, Danube University, Karl Dorrek Strasse 30, 3500, Krems, Austria
    Curr Psychiatry Rep 14:360-9. 2012
    ..This article summarizes the best available evidence regarding comparative benefits and harms of second-generation antidepressants for treating depressive disorders...
  6. doi Clinical heterogeneity in systematic reviews and health technology assessments: synthesis of guidance documents and the literature
    Gerald Gartlehner
    Danube University, Krems
    Int J Technol Assess Health Care 28:36-43. 2012
    ..The aim of this study was to synthesize best practices for addressing clinical heterogeneity in systematic reviews and health technology assessments (HTAs)...
  7. doi Comparative benefits and harms of second-generation antidepressants for treating major depressive disorder: an updated meta-analysis
    Gerald Gartlehner
    Danube University, Krems, Austria
    Ann Intern Med 155:772-85. 2011
    ..Second-generation antidepressants dominate the management of major depressive disorder (MDD), but evidence on the comparative benefits and harms of these agents is contradictory...
  8. doi The effect of study sponsorship on a systematically evaluated body of evidence of head-to-head trials was modest: secondary analysis of a systematic review
    Gerald Gartlehner
    Department of Evidence Based Medicine and Clinical Epidemiology, Danube University, Krems, Austria
    J Clin Epidemiol 63:117-25. 2010
    ..The objective of this study was to determine the effect of industry bias in a systematically reviewed body of evidence of head-to-head trials...
  9. doi Inadequate reporting of trials compromises the applicability of systematic reviews
    Gerald Gartlehner
    Department for Evidence based Medicine and Clinical Epidemiology, Danube University, Krems, Austria
    Int J Technol Assess Health Care 25:323-30. 2009
    ..This study aimed to determine whether information reported in studies included in systematic reviews was adequate enough to assess their applicability...
  10. ncbi Assessment of adverse effects and applicability--two areas not (yet) covered adequately in Cochrane reports
    Gerald Gartlehner
    Danube University, Krems, Austria
    Z Evid Fortbild Qual Gesundhwes 102:497-502. 2008
    ....
  11. ncbi Comparative benefits and harms of second-generation antidepressants: background paper for the American College of Physicians
    Gerald Gartlehner
    Danube University, Krems, Austria
    Ann Intern Med 149:734-50. 2008
    ..Second-generation antidepressants dominate the management of major depressive disorder, dysthymia, and subsyndromal depression. Evidence on the comparative benefits and harms is still accruing...
  12. ncbi Comparative risk for harms of second-generation antidepressants : a systematic review and meta-analysis
    Gerald Gartlehner
    Department for Evidence based Medicine and Clinical Epidemiology, Danube University Krems, Krems, Austria
    Drug Saf 31:851-65. 2008
    ..However, a comprehensive assessment of both benefits and harms is crucial to evaluate the net benefit...
  13. doi Direct versus indirect comparisons: a summary of the evidence
    Gerald Gartlehner
    Danube University, Krems, Austria
    Int J Technol Assess Health Care 24:170-7. 2008
    ..The aim of this study was to provide a comprehensive summary and interpretation of the current evidence on the use and validity of statistical methods to conduct indirect comparisons of treatment effects...
  14. pmc Differences in efficacy and safety of pharmaceutical treatments between men and women: an umbrella review
    Gerald Gartlehner
    Department for Evidence based Medicine and Clinical Epidemiology, Danube University Krems, Krems, Austria
    PLoS ONE 5:e11895. 2010
    ..The available body of evidence, however, was limited in quality and quantity, confining the range and certainty of our conclusions...
  15. doi Comparative effectiveness of second-generation antidepressants for accompanying anxiety, insomnia, and pain in depressed patients: a systematic review
    Kylie J Thaler
    Danube University Krems, Krems, Austria
    Depress Anxiety 29:495-505. 2012
    ....
  16. doi A case study of pooled-studies publications indicated potential for both valuable information and bias
    Kylie J Thaler
    Department for Evidence based Medicine and Clinical Epidemiology, Danube University Krems, 3500 Krems, Austria
    J Clin Epidemiol 66:1082-92. 2013
    ..We explored the characteristics of PSPs and their potential impact on a systematic review (SR)...
  17. doi Sexual dysfunction associated with second-generation antidepressants in patients with major depressive disorder: results from a systematic review with network meta-analysis
    Ursula Reichenpfader
    Department for Evidence based Medicine and Clinical Epidemiology, Danube University Krems, Dr Karl Dorrek Str 30, 3500, Krems, Austria
    Drug Saf 37:19-31. 2014
    ..Evidence indicates under-reporting of SD in efficacy studies. SD associated with antidepressant treatment is a serious side effect that may lead to early termination of treatment and worsening of quality of life...
  18. doi [GRADE guidelines: 11. Making an overall rating of confidence in effect estimates for a single outcome and for all outcomes]
    Angela Kaminski-Hartenthaler
    Donau Universität Krems, Department für Evidenzbasierte Medizin und Klinische Epidemiologie, Krems, Österreich Electronic address
    Z Evid Fortbild Qual Gesundhwes 107:638-45. 2013
    ..An overall rating of confidence in estimates of effect is only relevant in settings when recommendations are being made. In general, it is based on the critical outcome that provides the lowest confidence. ..
  19. doi [Clinical outcomes, health-related quality of life, and cost-effectiveness of a 6-month community- based lifestyle program for adults at increased cardiovascular risk in lower Austria]
    Ursula Reichenpfader
    Department für Evidenzbasierte Medizin und Klinische Epidemiologie, Donau Universität Krems, Krems, Osterreich
    Wien Med Wochenschr 162:321-9. 2012
    ..To investigate lifestyle intervention effects and cost-effectiveness of a structured 6-month exercise and nutrition program for individuals at high risk for cardiovascular disease...
  20. ncbi Second-generation antidepressants for seasonal affective disorder
    Kylie Thaler
    Department for Evidence based Medicine and Clinical Epidemiology, Danube University Krems, Krems, Austria
    Cochrane Database Syst Rev 12:CD008591. 2011
    ..Seasonal affective disorder (SAD) is a seasonal pattern of recurrent depressive episodes that is often treated with second-generation antidepressants (SGAs), light therapy or psychotherapy...
  21. doi Sentinel lymph node dissection only versus complete axillary lymph node dissection in early invasive breast cancer: a systematic review and meta-analysis
    Anna Glechner
    Danube University, Department for Evidence based Medicine and Clinical Epidemiology, Austria
    Eur J Cancer 49:812-25. 2013
    ..The aim of this review was to systematically assess the evidence on the comparative benefits and harms of ALND versus SLND for sentinel node positive breast cancer patients...
  22. pmc Bach Flower Remedies for psychological problems and pain: a systematic review
    Kylie Thaler
    Department for Evidence based Medicine and Clinical Epidemiology, Danube University, Krems, A 3500, Austria
    BMC Complement Altern Med 9:16. 2009
    ..We assessed whether Bach Flower Remedies (BFRs) are safe and efficacious for these indications by performing a systematic review of the literature...
  23. ncbi Antidepressants for the treatment of abdominal pain-related functional gastrointestinal disorders in children and adolescents
    Angela Kaminski
    Department for Evidence based Medicine and Clinical Epidemiology, Danube University Krems, Dr Karl Dorrek Strasse 30, Krems, Austria, 3500
    Cochrane Database Syst Rev 7:CD008013. 2011
    ..To date, the evidence on the benefits and harms of antidepressants for the treatment of abdominal pain-related FGIDs has not been assessed systematically...
  24. doi [Austrian patient information materials on PSA-screening do not meet international evidence-based standards]
    Michaela Strobelberger
    Department für Evidenzbasierte Medizin und Klinische Epidemiologie, Donau Universität, Krems, Austria
    Wien Med Wochenschr 161:89-98. 2011
    ..The aim of this paper was to evaluate all in Austria available patient information materials on PSA-screening with regard to their evidence-based content and their potential to facilitate informed decision-making...
  25. ncbi Perinatal depression: a systematic review of prevalence and incidence
    Norma I Gavin
    RTI International, 3040 Cornwallis Road, PO Box 12194, Research Triangle Park, NC 27709 2194, USA
    Obstet Gynecol 106:1071-83. 2005
    ..We systematically review evidence on the prevalence and incidence of perinatal depression and compare these rates with those of depression in women at non-childbearing times...
  26. pmc Efficacy and safety of anakinra for the treatment of rheumatoid arthritis: an update of the Oregon Drug Effectiveness Review Project
    Kylie Thaler
    Department for Evidence based Medicine and Clinical Epidemiology, Danube University Krems, Krems, Austria
    Biologics 3:485-98. 2009
    ..To systematically review the general and comparative efficacy and safety of anakinra for rheumatoid arthritis...
  27. doi Mixed treatment comparison of the treatment discontinuations of biologic disease-modifying antirheumatic drugs in adults with rheumatoid arthritis
    Rishi J Desai
    Division of Pharmaceutical Outcomes and Policy, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, USA
    Ann Pharmacother 46:1491-505. 2012
    ..Very little information is available on comparative discontinuation rates of the biologics...
  28. doi [GRADE guidelines: 9. Rating up the quality of evidence]
    Christina Kien
    Donau Universität Krems, Department für Evidenzbasierte Medizin und Klinische Epidemiologie, Krems, Austria
    Z Evid Fortbild Qual Gesundhwes 107:249-55. 2012
    ..Other considerations include the rapidity of the response, the underlying trajectory of the condition and indirect evidence...
  29. doi Semi-automating the manual literature search for systematic reviews increases efficiency
    Andrea L Chapman
    Department for Evidence based Medicine and Clinical Epidemiology, Danube University Krems, Krems, Austria
    Health Info Libr J 27:22-7. 2010
    ....