J Small

Summary

Affiliation: Austrian Academy of Sciences
Country: Austria

Publications

  1. pmc Modulation of substrate adhesion dynamics via microtubule targeting requires kinesin-1
    Olga Krylyshkina
    Institute of Molecular Biology, Austrian Academy of Sciences, Billrothsthstrasse 11, Salzburg 5020, Austria
    J Cell Biol 156:349-59. 2002
  2. ncbi request reprint The last but not the least: the origin and significance of trailing adhesions in fibroblastic cells
    Raphaela Rid
    Institute of Molecular Biology, Austrian Academy of Sciences, Salzburg, Austria
    Cell Motil Cytoskeleton 61:161-71. 2005
  3. pmc Paxillin-dependent stimulation of microtubule catastrophes at focal adhesion sites
    Andrey Efimov
    Department of Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, TN, USA
    J Cell Sci 121:196-204. 2008
  4. ncbi request reprint Functional design in the actin cytoskeleton
    J V Small
    Institute of Molecular Biology Austrian Academy of Sciences Billrothstrasse 11 A 5020 Salzburg Austria
    Curr Opin Cell Biol 11:54-60. 1999
  5. ncbi request reprint Cytoskeleton cross-talk during cell motility
    J V Small
    Department of Cell Biology, Institute of Molecular Biology, Austrian Academy of Sciences, Salzburg
    FEBS Lett 452:96-9. 1999
  6. ncbi request reprint Visualising the actin cytoskeleton
    J Small
    Institute of Molecular Biology, Austrian Academy of Sciences, Salzburg, Austria
    Microsc Res Tech 47:3-17. 1999
  7. ncbi request reprint The lamellipodium: where motility begins
    J Victor Small
    Dept of Cell Biology, Institute of Molecular Biology, Austrian Academy of Sciences, Billrothstrasse 11, 5020 Salzburg, Austria
    Trends Cell Biol 12:112-20. 2002
  8. ncbi request reprint Microtubules meet substrate adhesions to arrange cell polarity
    J Victor Small
    Institute of Molecular Biology, Austrian Academy of Sciences, Billrothstrasse 11, 5020 Salzburg, Austria
    Curr Opin Cell Biol 15:40-7. 2003
  9. ncbi request reprint PREL1 provides a link from Ras signalling to the actin cytoskeleton via Ena/VASP proteins
    Andrea Jenzora
    Department of Cell Biology, German Research Centre for Biotechnology, 38124 Braunschweig, Germany
    FEBS Lett 579:455-63. 2005
  10. pmc Raf-1 regulates Rho signaling and cell migration
    Karin Ehrenreiter
    Department of Microbiology and Genetics, Max F Perutz Laboratories, University Departments at the Vienna Biocenter, 1030 Vienna, Austria
    J Cell Biol 168:955-64. 2005

Collaborators

Detail Information

Publications29

  1. pmc Modulation of substrate adhesion dynamics via microtubule targeting requires kinesin-1
    Olga Krylyshkina
    Institute of Molecular Biology, Austrian Academy of Sciences, Billrothsthstrasse 11, Salzburg 5020, Austria
    J Cell Biol 156:349-59. 2002
    ..We conclude that conventional kinesin is not required for the guidance of microtubules into substrate adhesions, but is required for the focal delivery of a component(s) that retards their growth or promotes their disassembly...
  2. ncbi request reprint The last but not the least: the origin and significance of trailing adhesions in fibroblastic cells
    Raphaela Rid
    Institute of Molecular Biology, Austrian Academy of Sciences, Salzburg, Austria
    Cell Motil Cytoskeleton 61:161-71. 2005
    ..We conclude that persistent and dynamic anchorage of the cell rear is needed for the maintenance of continuous unidirectional movement of fibroblasts...
  3. pmc Paxillin-dependent stimulation of microtubule catastrophes at focal adhesion sites
    Andrey Efimov
    Department of Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, TN, USA
    J Cell Sci 121:196-204. 2008
    ..We suggest that paxillin influences microtubule dynamics at focal adhesions by serving as a scaffold for a putative catastrophe factor and/or regulating its exposure to microtubules...
  4. ncbi request reprint Functional design in the actin cytoskeleton
    J V Small
    Institute of Molecular Biology Austrian Academy of Sciences Billrothstrasse 11 A 5020 Salzburg Austria
    Curr Opin Cell Biol 11:54-60. 1999
    ..Cell polarity is acquired by the development of an asymmetric pattern of substrate contacts, effected in a specific, site-directed manner by the delivery of adhesion-site modulators along microtubules...
  5. ncbi request reprint Cytoskeleton cross-talk during cell motility
    J V Small
    Department of Cell Biology, Institute of Molecular Biology, Austrian Academy of Sciences, Salzburg
    FEBS Lett 452:96-9. 1999
    ..By exerting relaxing effects on substrate contact assemblies in a site- and dose-specific manner, microtubules can promote both protrusion at the front and retraction at the rear, and thereby control cell polarity...
  6. ncbi request reprint Visualising the actin cytoskeleton
    J Small
    Institute of Molecular Biology, Austrian Academy of Sciences, Salzburg, Austria
    Microsc Res Tech 47:3-17. 1999
    ..Included also is a comparison of cooled CCD technology, confocal and 2-photon fluorescence microscopy of living and fixed cells, as well as a critique of current procedures for electron microscopy...
  7. ncbi request reprint The lamellipodium: where motility begins
    J Victor Small
    Dept of Cell Biology, Institute of Molecular Biology, Austrian Academy of Sciences, Billrothstrasse 11, 5020 Salzburg, Austria
    Trends Cell Biol 12:112-20. 2002
    ..Here, we give a spatial inventory of the many molecular players in this dynamic domain of the actin cytoskeleton in order to highlight the open questions and the challenges ahead...
  8. ncbi request reprint Microtubules meet substrate adhesions to arrange cell polarity
    J Victor Small
    Institute of Molecular Biology, Austrian Academy of Sciences, Billrothstrasse 11, 5020 Salzburg, Austria
    Curr Opin Cell Biol 15:40-7. 2003
    ..Targeting serves to bring molecular complexes bound at the tips and along microtubules in close proximity with adhesion complexes, to promote adhesion disassembly and remodelling of the actin cytoskeleton...
  9. ncbi request reprint PREL1 provides a link from Ras signalling to the actin cytoskeleton via Ena/VASP proteins
    Andrea Jenzora
    Department of Cell Biology, German Research Centre for Biotechnology, 38124 Braunschweig, Germany
    FEBS Lett 579:455-63. 2005
    ..Thus, our data pinpoint PREL1 as the first direct link between Ras signalling and cytoskeletal remodelling via Ena/VASP proteins during cell migration and spreading...
  10. pmc Raf-1 regulates Rho signaling and cell migration
    Karin Ehrenreiter
    Department of Microbiology and Genetics, Max F Perutz Laboratories, University Departments at the Vienna Biocenter, 1030 Vienna, Austria
    J Cell Biol 168:955-64. 2005
    ..Thus, Raf-1 plays an essential, kinase-independent function as a spatial regulator of Rho downstream signaling during migration...
  11. ncbi request reprint The comings and goings of actin: coupling protrusion and retraction in cell motility
    J Victor Small
    Institute of Molecular Biotechnology, Austrian Academy of Sciences, Dr Bohr Gasse 3 5, Vienna, 1030, Austria
    Curr Opin Cell Biol 17:517-23. 2005
    ..In addition to driving protrusion, the lamellipodium appears to play a role in supplying filaments to the lamella for the assembly of the contractile network required for traction...
  12. ncbi request reprint E-cadherin endocytosis regulates the activity of Rap1: a traffic light GTPase at the crossroads between cadherin and integrin function
    Fiorella Balzac
    Department of Genetics, Biology and Biochemistry, University of Torino, Via Santena 5 bis, Torino, 10126, Italy
    J Cell Sci 118:4765-83. 2005
    ..Our findings provide the first evidence of an E-cadherin-modulated endosomal signaling pathway involving Rap1, and suggest that cadherins may have a novel modulatory role in integrin adhesive functions by fine-tuning Rap1 activation...
  13. doi request reprint Differentially oriented populations of actin filaments generated in lamellipodia collaborate in pushing and pausing at the cell front
    Stefan A Koestler
    Institute of Molecular Biotechnology, Austrian Academy of Sciences, Dr Bohr Gasse 3, 1030, Vienna, Austria
    Nat Cell Biol 10:306-13. 2008
    ....
  14. pmc Building the actin cytoskeleton: filopodia contribute to the construction of contractile bundles in the lamella
    Maria Nemethova
    Institute of Molecular Biotechnology, Austrian Academy of Sciences, Vienna 1030, Austria
    J Cell Biol 180:1233-44. 2008
    ..Comparable results were obtained with B16 melanoma cells. These and other findings support the idea that filaments generated in filopodia and lamellipodia for protrusion are recycled for seeding actomyosin arrays for use in retraction...
  15. pmc SWAP-70 identifies a transitional subset of actin filaments in motile cells
    Pirta Hilpelä
    Institut fur Allgemeine Zoologie und Genetik, Westfalische Wilhelms Universitat Munster, D 48149 Munster, Germany
    Mol Biol Cell 14:3242-53. 2003
    ..We propose that SWAP-70 regulates the actin cytoskeleton as an effector or adaptor protein in response to agonist stimulated phosphatidylinositol (3,4)-bisphosphate production and cell protrusion...
  16. pmc Nanometer targeting of microtubules to focal adhesions
    Olga Krylyshkina
    Institute of Molecular Biology, Salzburg A5020, Austria
    J Cell Biol 161:853-9. 2003
    ....
  17. ncbi request reprint IRSp53 is colocalised with WAVE2 at the tips of protruding lamellipodia and filopodia independently of Mena
    Hiroyuki Nakagawa
    Department of Cell Biology, Institute of Molecular Biology, Austrian Academy of Sciences, Billrothstrasse 11, Salzburg A 5020, Austria
    J Cell Sci 116:2577-83. 2003
    ..These results suggest an alternative modulatory role for IRSp53 in the extension of both filopodia and lamellipodia, through WAVE2...
  18. ncbi request reprint How do microtubules guide migrating cells?
    J Victor Small
    Nat Rev Mol Cell Biol 3:957-64. 2002
    ..Here, we propose that microtubules determine cell polarity by modulating the pattern of adhesions that a cell develops with the underlying matrix, through focal inhibitions of contractility...
  19. ncbi request reprint Regulation of substrate adhesion dynamics during cell motility
    Irina Kaverina
    Department of Cell Biology, Institute of Molecular Biology, Austrian Academy of Sciences, Billrothstrasse 11, Salzburg 5020, Austria
    Int J Biochem Cell Biol 34:746-61. 2002
    ..Possible mechanisms of cross-talk between the microtubule and actin cytoskeletons in determining polarity are discussed...
  20. ncbi request reprint Tensile stress stimulates microtubule outgrowth in living cells
    Irina Kaverina
    Institute of Molecular Biology of the Austrian Academy of Sciences, A 5020, Austria
    J Cell Sci 115:2283-91. 2002
    ..We propose a model for this mechano-sensing phenomenon whereby microtubule polymerisation is stimulated and guided through the interaction of a microtubule tip complex with actin filaments under tension...
  21. ncbi request reprint Visualisation of the actin cytoskeleton by cryo-electron microscopy
    Guenter P Resch
    Institute of Molecular Biology, Department Cell Biology, Billrothstrasse 11, A 5020 Salzburg, Austria
    J Cell Sci 115:1877-82. 2002
    ....
  22. pmc Arp2/3 complex interactions and actin network turnover in lamellipodia
    Frank P L Lai
    Cytoskeleton Dynamics Group, Helmholtz Centre for Infection Research, Braunschweig, Germany
    EMBO J 27:982-92. 2008
    ..Network turnover is additionally regulated by the spatially segregated activities of capping protein at the tip and cofilin throughout the mesh...
  23. doi request reprint Facing up to Mena: Tes(ting) times for EVH1 domains
    J Victor Small
    Nat Cell Biol 10:118-20. 2008
  24. ncbi request reprint PREL1 provides a link from Ras signalling to the actin cytoskeleton via Ena/VASP proteins
    Andrea Jenzora
    Department of Cell Biology, German Research Centre for Biotechnology GBF, Braunschweig, Germany
    FEBS Lett 580:455-63. 2006
    ..Thus, our data pinpoint PREL1 as the first direct link between Ras signalling and cytoskeletal remodelling via Ena/VASP proteins during cell migration and spreading...
  25. pmc Filopodia formation in the absence of functional WAVE- and Arp2/3-complexes
    Anika Steffen
    Signalling and Motility Group, German Research Centre for Biotechnology, D 38124 Braunschweig, Germany
    Mol Biol Cell 17:2581-91. 2006
    ..These data suggest that the molecular mechanism of filopodia formation is conserved throughout evolution from Dictyostelium to mammals and show that lamellipodia and filopodia formation are functionally separable...
  26. ncbi request reprint PIP(2)-PDZ domain binding controls the association of syntenin with the plasma membrane
    Pascale Zimmermann
    Laboratory for Glycobiology and Developmental Genetics, Department of Human Genetics, University of Leuven, B 3000 Leuven, Belgium
    Mol Cell 9:1215-25. 2002
    ..These observations suggest that local changes in phosphoinositide concentration control the association of PDZ proteins with their target receptors at the plasma membrane...
  27. ncbi request reprint Pure F-actin networks are distorted and branched by steps in the critical-point drying method
    Guenter P Resch
    Department of Cell Biology, Institute of Molecular Biology, Billrothstrasse 11, A 5020 Salzburg, Austria
    J Struct Biol 137:305-12. 2002
    ....
  28. pmc Bicaudal D induces selective dynein-mediated microtubule minus end-directed transport
    Casper C Hoogenraad
    MGC Department of Neuroscience, Erasmus University, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    EMBO J 22:6004-15. 2003
    ..Our findings provide a novel model system for dissection of the molecular mechanism of dynein motility...
  29. doi request reprint Correlated light and electron microscopy of the cytoskeleton
    Sonja Auinger
    Institute of Molecular Biotechnology, Dr Bohr Gasse 3, 1030 Vienna, Austria
    Methods Cell Biol 88:257-72. 2008
    ..The technique is applicable to alternative processing procedures after fixation, including cryoelectron tomography...