M Gimona

Summary

Affiliation: Austrian Academy of Sciences
Country: Austria

Publications

  1. ncbi Functional plasticity of CH domains
    Mario Gimona
    Department of Cell Biology, Institute of Molecular Biology, Austrian Academy of Sciences, Salzburg, Austria
    FEBS Lett 513:98-106. 2002
  2. ncbi The single CH domain of calponin is neither sufficient nor necessary for F-actin binding
    M Gimona
    Institute of Molecular Biology, Department of Cell Biology, Austrian Academy of Sciences, Billrothstrasse 11, A 5020 Salzburg, Austria
    J Cell Sci 111:1813-21. 1998
  3. pmc Calponin repeats regulate actin filament stability and formation of podosomes in smooth muscle cells
    Mario Gimona
    Institute of Molecular Biology, Department of Cell Biology, Austrian Academy of Sciences, A 5020 Salzburg, Austria
    Mol Biol Cell 14:2482-91. 2003
  4. ncbi Beta-actin specific monoclonal antibody
    M Gimona
    Institute of Molecular Biology, Austrian Academy of Sciences, Salzburg
    Cell Motil Cytoskeleton 27:108-16. 1994
  5. ncbi Variable and constant regions in the C-terminus of vinculin and metavinculin. Cloning and expression of fragments in E. coli
    P Strasser
    Institute of Molecular Biology, Austrian Academy of Sciences, Salzburg
    FEBS Lett 317:189-94. 1993
  6. ncbi Mammalian calponin. Identification and expression of genetic variants
    P Strasser
    Institute of Molecular Biology, Austrian Academy of Sciences, Salzburg
    FEBS Lett 330:13-8. 1993
  7. ncbi Actin isoform compartments in chicken gizzard smooth muscle cells
    A J North
    Institute of Molecular Biology, Austrian Academy of Sciences, Salzburg
    J Cell Sci 107:445-55. 1994
  8. ncbi Calponin is localised in both the contractile apparatus and the cytoskeleton of smooth muscle cells
    A J North
    Institute of Molecular Biology, Austrian Academy of Sciences, Salzburg
    J Cell Sci 107:437-44. 1994
  9. ncbi UNC-87 is an actin-bundling protein
    W J Kranewitter
    Department of Cell Biology, Institute of Molecular Biology, Austrian Academy of Sciences, Billrothstrasse 11, A 5020 Salzburg, Austria
    J Biol Chem 276:6306-12. 2001
  10. ncbi Mapping the zinc ligands of S100A2 by site-directed mutagenesis
    T B Stradal
    Institute of Molecular Biology, Department of Cell Biology, Austrian Academy of Sciences, Billrothstrasse 11, A 5020 Salzburg, Austria
    J Biol Chem 275:13219-27. 2000

Collaborators

Detail Information

Publications33

  1. ncbi Functional plasticity of CH domains
    Mario Gimona
    Department of Cell Biology, Institute of Molecular Biology, Austrian Academy of Sciences, Salzburg, Austria
    FEBS Lett 513:98-106. 2002
    ....
  2. ncbi The single CH domain of calponin is neither sufficient nor necessary for F-actin binding
    M Gimona
    Institute of Molecular Biology, Department of Cell Biology, Austrian Academy of Sciences, Billrothstrasse 11, A 5020 Salzburg, Austria
    J Cell Sci 111:1813-21. 1998
    ..Instead, the carboxy-terminal tandem repeats of h1 and h2 calponin are shown to harbour a second, independent actin binding motif...
  3. pmc Calponin repeats regulate actin filament stability and formation of podosomes in smooth muscle cells
    Mario Gimona
    Institute of Molecular Biology, Department of Cell Biology, Austrian Academy of Sciences, A 5020 Salzburg, Austria
    Mol Biol Cell 14:2482-91. 2003
    ....
  4. ncbi Beta-actin specific monoclonal antibody
    M Gimona
    Institute of Molecular Biology, Austrian Academy of Sciences, Salzburg
    Cell Motil Cytoskeleton 27:108-16. 1994
    ..The characteristics of the antibody indicate that it should serve as a useful tool for studying isoactin distribution and function...
  5. ncbi Variable and constant regions in the C-terminus of vinculin and metavinculin. Cloning and expression of fragments in E. coli
    P Strasser
    Institute of Molecular Biology, Austrian Academy of Sciences, Salzburg
    FEBS Lett 317:189-94. 1993
    ..35 and 10.25 for the recombinant proteins. Biochemical and structural features of the metavinculin-specific sequence and the conserved vinculin/metavinculin carboxy-terminus are discussed...
  6. ncbi Mammalian calponin. Identification and expression of genetic variants
    P Strasser
    Institute of Molecular Biology, Austrian Academy of Sciences, Salzburg
    FEBS Lett 330:13-8. 1993
    ..The sequence data demonstrate that the two mammalian calponin variants do not arise via alternative splicing but are encoded by different genes...
  7. ncbi Actin isoform compartments in chicken gizzard smooth muscle cells
    A J North
    Institute of Molecular Biology, Austrian Academy of Sciences, Salzburg
    J Cell Sci 107:445-55. 1994
    ..A model of the structural organisation of the cell is presented and the possible roles of the cytoskeleton are discussed...
  8. ncbi Calponin is localised in both the contractile apparatus and the cytoskeleton of smooth muscle cells
    A J North
    Institute of Molecular Biology, Austrian Academy of Sciences, Salzburg
    J Cell Sci 107:437-44. 1994
    ....
  9. ncbi UNC-87 is an actin-bundling protein
    W J Kranewitter
    Department of Cell Biology, Institute of Molecular Biology, Austrian Academy of Sciences, Billrothstrasse 11, A 5020 Salzburg, Austria
    J Biol Chem 276:6306-12. 2001
    ..These data identify UNC-87 as an actin-bundling protein and highlight the calponin-like repeats as a novel actin-binding module...
  10. ncbi Mapping the zinc ligands of S100A2 by site-directed mutagenesis
    T B Stradal
    Institute of Molecular Biology, Department of Cell Biology, Austrian Academy of Sciences, Billrothstrasse 11, A 5020 Salzburg, Austria
    J Biol Chem 275:13219-27. 2000
    ..These results provide new information about the mechanism and the site(s) of zinc binding in S100A2...
  11. ncbi GEF at work: Vav in protruding filopodia
    W J Kranewitter
    Institute of Molecular Biology, Department of Cell Biology, Austrian Academy of Sciences, Salzburg, Austria
    Cell Motil Cytoskeleton 49:154-60. 2001
    ..Upon retraction, the signal was rapidly lost, indicating that Vav undergoes a specific and transient translocation in response to actin-based, protrusive events in filopodia...
  12. pmc Porcine vinculin and metavinculin differ by a 68-residue insert located close to the carboxy-terminal part of the molecule
    M Gimona
    Institute of Molecular Biology, Austrian Academy of Sciences, Salzburg
    EMBO J 7:2329-34. 1988
    ....
  13. ncbi CLAMP, a novel microtubule-associated protein with EB-type calponin homology
    Gerard W Dougherty
    Section on Structural Cell Biology, NIDCD, NIH, Bethesda, Maryland 20892 8027, USA
    Cell Motil Cytoskeleton 62:141-56. 2005
    ..We propose that this protein, designated CLAMP, is a novel MAP and represents a new member of the CH domain protein family...
  14. ncbi Tyrosine phosphorylation of calponins. Inhibition of the interaction with F-actin
    Julien Abouzaglou
    Centre de Recherches de Biochimie Macromoléculaire du CNRS, Montpellier, France
    Eur J Biochem 271:2615-23. 2004
    ....
  15. ncbi CRP2 is an autonomous actin-binding protein
    Markus Grubinger
    Department of Cell Biology, Austrian Academy of Sciences, Billrothstrasse 11, A 5020 Salzburg, Austria
    FEBS Lett 557:88-92. 2004
    ....
  16. ncbi The role of calponin in the gene profile of metastatic cells: inhibition of metastatic cell motility by multiple calponin repeats
    Thomas Lener
    Institute of Molecular Biology, Department of Cell Biology, Austrian Academy of Sciences, Billrothstrasse 11, A 5020, Salzburg, Austria
    FEBS Lett 556:221-6. 2004
    ....
  17. ncbi Actin cytoskeleton remodelling via local inhibition of contractility at discrete microdomains
    Gerald Burgstaller
    Institute of Molecular Biology, Department of Cell Biology, Austrian Academy of Sciences, Billrothstrasse 11, 5020 Salzburg, Austria
    J Cell Sci 117:223-31. 2004
    ..The results provide direct evidence for the spatially restricted inhibition of contractility via the recruitment and accumulation of cortactin and p190RhoGAP...
  18. ncbi Podosome formation in cultured A7r5 vascular smooth muscle cells requires Arp2/3-dependent de-novo actin polymerization at discrete microdomains
    Irina Kaverina
    Institute of Molecular Biology, Department of Cell Biology, Austrian Academy of Sciences Billrothstrasse 11, A 5020 Salzburg, Austria
    J Cell Sci 116:4915-24. 2003
    ....
  19. pmc UNC-87, a calponin-related protein in C. elegans, antagonizes ADF/cofilin-mediated actin filament dynamics
    Sawako Yamashiro
    Department of Pathology, Emory University, Atlanta, GA 30322, USA
    J Cell Sci 120:3022-33. 2007
    ..Our results demonstrate that actin binding via calponin-like repeats competes with ADF/cofilin-driven cytoskeletal turnover, and is critical for providing the spatiotemporal regulation of actin filament stability...
  20. ncbi Calponins: adaptable modular regulators of the actin cytoskeleton
    Guido T Rozenblum
    Unit of Actin Cytoskeleton Regulation, Consorzio Mario Negri Sud, Department of Cell Biology and Oncology, Via Nazionale 8a, 66030 Santa Maria Imbaro, Italy
    Int J Biochem Cell Biol 40:1990-5. 2008
    ..From these various cellular functions the biological role of calponin is now slowly emerging, namely that of an actin filament-stabilizing molecule that contributes to physiological thin filament turnover rates in different cell types...
  21. ncbi The molecular basis for the autoregulation of calponin by isoform-specific C-terminal tail sequences
    Gerald Burgstaller
    Institute of Molecular Biology, Department of Cell Biology, Austrian Academy of Sciences, Billrothstrasse 11, A 5020 Salzburg, Austria
    J Cell Sci 115:2021-9. 2002
    ..Finally we demonstrate that the tail sequences regulate the second actin-binding site (ABS2) and not the strong actin-binding ABS1 region in CaP...
  22. ncbi The microfilament system in the formation of invasive adhesions
    Mario Gimona
    Unit of Actin Cytoskeleton Regulation, Consorzio Mario Negri Sud, Department of Cell Biology and Oncology, Via Nazionale 8a, Santa Maria Imbaro, Italy
    Semin Cancer Biol 18:23-34. 2008
    ....
  23. ncbi Synthetic actin-binding domains reveal compositional constraints for function
    Maria Lorenzi
    Consorzio Mario Negri Sud, Department of Cell Biology and Oncology, Via Nazionale 8a, I 66030 Santa Maria Imbaro, Italy
    Int J Biochem Cell Biol 40:1806-16. 2008
    ....
  24. ncbi Implications on zinc binding to S100A2
    Michael Koch
    Department of Biology, University of Konstanz, Universitatsstrasse 10, Postfach M665, 78457 Konstanz, Germany
    Biochim Biophys Acta 1773:457-70. 2007
    ..These findings imply that S100A2 is regulated by both Zn2+ and Ca2+, and suggest that Zn2+ might deactivate S100A2 by inhibiting response to intracellular Ca2+ signals...
  25. ncbi Adhesions that mediate invasion
    Mario Gimona
    Unit of Actin Cytoskeleton Regulation, Consorzio Mario Negri Sud, Department of Cell Biology and Oncology, Via Nazionale 8a, 66030 Santa Maria Imbaro, Italy
    Int J Biochem Cell Biol 38:1875-92. 2006
    ..Here, we will discuss the recent advances and developments in this field, and provide our provisional outlook into the future understanding of the principles of focal extracellular matrix degradation by podosomes and invadopodia...
  26. ncbi Matrix-degrading podosomes in smooth muscle cells
    Thomas Lener
    Division of Cell Biology, University of Salzburg, Hellbrunnerstrasse 34, A 5020 Salzburg, Austria
    Eur J Cell Biol 85:183-9. 2006
    ....
  27. ncbi The actin cytoskeleton, RAS-cAMP signaling and mitochondrial ROS in yeast apoptosis
    Michael Breitenbach
    University of Salzburg, 5020 Salzburg, Austria
    Trends Cell Biol 15:637-9. 2005
    ..This effect can be suppressed by downregulation of the RAS-cAMP signaling pathway, thus establishing the existence of a new and complex regulatory network...
  28. ncbi Podosome-mediated matrix resorption and cell motility in vascular smooth muscle cells
    Gerald Burgstaller
    Consorzio Mario Negri Sud, Dept of Cell Biology and Oncology, Unit of Actin Cytoskeleton Regulation, Via Nazionale 8a, I 66030 Santa Maria Imbaro, Italy
    Am J Physiol Heart Circ Physiol 288:H3001-5. 2005
    ..Our findings demonstrate that podosome formation is the potential mechanism underlying the ability of VSMCs to traverse the surrounding basement membrane and escape the barrier of the tunica media in vascular diseases...
  29. ncbi Protein kinase C delta induces Src kinase activity via activation of the protein tyrosine phosphatase PTP alpha
    Dominique T Brandt
    Medizinische Hochschule Hannover, Department of Nephrology, 30625 Hannover, Germany
    J Biol Chem 278:34073-8. 2003
    ....
  30. ncbi Conventional protein kinase C mediates phorbol-dibutyrate-induced cytoskeletal remodeling in a7r5 smooth muscle cells
    Chi Ming Hai
    Department of Molecular Pharmacology, Physiology, and Biotechnology, Austrian Academy of Sciences, Salzburg, Austria
    Exp Cell Res 280:64-74. 2002
    ..The podosome columns could represent molecular scaffolds where PKC-alpha phosphorylates regulatory proteins necessary for Ca(2+) sensitization in smooth muscle cells...
  31. ncbi Protein kinase C induces actin reorganization via a Src- and Rho-dependent pathway
    Dominique Brandt
    Medizinische Hochschule Hannover, Department of Nephrology, 30625 Hannover, Germany
    J Biol Chem 277:20903-10. 2002
    ..Our data provide substantial evidence for a model elucidating the molecular mechanisms of PKC-induced actin rearrangements...
  32. ncbi Normalization of nomenclature for peptide motifs as ligands of modular protein domains
    Rein Aasland
    Department of Molecular Biology, University of Bergen, 5020 Bergen, Norway
    FEBS Lett 513:141-4. 2002
    ..This proposal will be reviewed in the future and will therefore be open for the inclusion of new rules, modifications and changes...
  33. doi Assembly and biological role of podosomes and invadopodia
    Mario Gimona
    Unit of Actin Cytoskeleton Regulation, Consorzio Mario Negri Sud, Department of Cell Biology and Oncology, Via Nazionale 8a, 66030 Santa Maria Imbaro Chieti, Italy
    Curr Opin Cell Biol 20:235-41. 2008
    ..The stage is now set to unravel their roles in the physiology and pathology of tissue plasticity and repair...