Marinov G, Wang J, Handler D, Wold B, Weng Z, Hannon G, et al. Pitfalls of mapping high-throughput sequencing data to repetitive sequences: Piwi's genomic targets still not identified. Dev Cell. 2015;32:765-71 pubmed publisher
..Here we reanalyze their data and report that the underlying deep-sequencing dataset does not support the authors' genome-wide conclusions. ..
Mohn F, Sienski G, Handler D, Brennecke J. The rhino-deadlock-cutoff complex licenses noncanonical transcription of dual-strand piRNA clusters in Drosophila. Cell. 2014;157:1364-79 pubmed publisher
..Likely, this process involves 5' end protection of nascent RNAs and suppression of transcription termination. Our data provide key insight into the regulation and evolution of piRNA clusters...
Hayashi R, Handler D, Ish Horowicz D, Brennecke J. The exon junction complex is required for definition and excision of neighboring introns in Drosophila. Genes Dev. 2014;28:1772-85 pubmed publisher
..Based on a transcriptome-wide analysis, we propose that the dependency of splicing on the EJC is exploited as a means to control the temporal order of splicing events. ..