J Attems

Summary

Country: Austria

Publications

  1. ncbi Incidence of cerebrovascular lesions in Alzheimer's disease: a postmortem study
    Kurt A Jellinger
    Institute of Clinical Neurobiology, 18 Kenyongasse, 1070 Vienna, Austria
    Acta Neuropathol 105:14-7. 2003
  2. ncbi Topographical distribution of cerebral amyloid angiopathy and its effect on cognitive decline are influenced by Alzheimer disease pathology
    Johannes Attems
    Institute of Pathology, Otto Wagner Hospital, Baumgartner Hohe 1, A 1145, Vienna, Austria
    J Neurol Sci 257:49-55. 2007
  3. ncbi Amyloid beta peptide 1-42 highly correlates with capillary cerebral amyloid angiopathy and Alzheimer disease pathology
    Johannes Attems
    Institute of Pathology, Otto Wagner Hospital, Baumgartner Hoehe 1, 1140, Vienna, Austria
    Acta Neuropathol 107:283-91. 2004
  4. ncbi The clinical diagnostic accuracy rate regarding the immediate cause of death in a hospitalized geriatric population; an autopsy study of 1594 patients
    Johannes Attems
    Pathologic Bacteriologic Institute, SMZ Otto Wagner Hospital, Vienna, Austria
    Wien Med Wochenschr 154:159-62. 2004
  5. ncbi Cause of death in demented and non-demented elderly inpatients; an autopsy study of 308 cases
    Johannes Attems
    Otto Wagner Hospital, Department of Pathology, Baumgartner Hohe 1, A 1145 Vienna, Austria
    J Alzheimers Dis 8:57-62. 2005
  6. ncbi Sporadic cerebral amyloid angiopathy: pathology, clinical implications, and possible pathomechanisms
    Johannes Attems
    Pathologic Institute, Otto Wagner Hospital, Baumgartner Hohe 1, 1145, Vienna, Austria
    Acta Neuropathol 110:345-59. 2005
  7. ncbi Calcium-binding protein secretagogin-expressing neurones in the human hippocampus are largely resistant to neurodegeneration in Alzheimer's disease
    J Attems
    Institute of Pathology, Otto Wagner Hospital, Baumgartner Hoehe, Vienna, Austria
    Neuropathol Appl Neurobiol 34:23-32. 2008
  8. ncbi Olfactory tau pathology in Alzheimer disease and mild cognitive impairment
    J Attems
    Department of Pathology, Otto Wagner Hospital, Vienna, Austria
    Clin Neuropathol 25:265-71. 2006
  9. doi Correlations between cortical and subcortical tau pathology
    J Attems
    Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK Institute for Clinical Neurobiology, Vienna, Austria
    Neuropathol Appl Neurobiol 38:582-90. 2012
  10. doi Cerebral amyloid angiopathy in Lewy body disease
    K A Jellinger
    Institute of Clinical Neurobiology, Vienna, Austria
    J Neural Transm 115:473-82. 2008

Collaborators

Detail Information

Publications32

  1. ncbi Incidence of cerebrovascular lesions in Alzheimer's disease: a postmortem study
    Kurt A Jellinger
    Institute of Clinical Neurobiology, 18 Kenyongasse, 1070 Vienna, Austria
    Acta Neuropathol 105:14-7. 2003
    ....
  2. ncbi Topographical distribution of cerebral amyloid angiopathy and its effect on cognitive decline are influenced by Alzheimer disease pathology
    Johannes Attems
    Institute of Pathology, Otto Wagner Hospital, Baumgartner Hohe 1, A 1145, Vienna, Austria
    J Neurol Sci 257:49-55. 2007
    ..These results indicate a strong association of AD with CAA, but do not unequivocally support reports suggesting CAA to be an independent risk factor for cognitive decline, except for a subgroup of demented patients lacking any ADP...
  3. ncbi Amyloid beta peptide 1-42 highly correlates with capillary cerebral amyloid angiopathy and Alzheimer disease pathology
    Johannes Attems
    Institute of Pathology, Otto Wagner Hospital, Baumgartner Hoehe 1, 1140, Vienna, Austria
    Acta Neuropathol 107:283-91. 2004
    ..These data support the concept of a neuronal origin of Abeta via drainage from interstitial fluid from the central nervous system along basement membranes to capillaries...
  4. ncbi The clinical diagnostic accuracy rate regarding the immediate cause of death in a hospitalized geriatric population; an autopsy study of 1594 patients
    Johannes Attems
    Pathologic Bacteriologic Institute, SMZ Otto Wagner Hospital, Vienna, Austria
    Wien Med Wochenschr 154:159-62. 2004
    ..In the geriatric population the autopsy rate is low, leading to mortality statistics often based on clinical diagnoses alone...
  5. ncbi Cause of death in demented and non-demented elderly inpatients; an autopsy study of 308 cases
    Johannes Attems
    Otto Wagner Hospital, Department of Pathology, Baumgartner Hohe 1, A 1145 Vienna, Austria
    J Alzheimers Dis 8:57-62. 2005
    ..Our data emphasize the high incidence of bronchopneumonia as a COD in patients suffering from AD...
  6. ncbi Sporadic cerebral amyloid angiopathy: pathology, clinical implications, and possible pathomechanisms
    Johannes Attems
    Pathologic Institute, Otto Wagner Hospital, Baumgartner Hohe 1, 1145, Vienna, Austria
    Acta Neuropathol 110:345-59. 2005
    ..As for the origin of Abeta in CAA, it may be both produced by smooth muscle cells (vessel wall) and derived from neurons in the course of perivascular drainage...
  7. ncbi Calcium-binding protein secretagogin-expressing neurones in the human hippocampus are largely resistant to neurodegeneration in Alzheimer's disease
    J Attems
    Institute of Pathology, Otto Wagner Hospital, Baumgartner Hoehe, Vienna, Austria
    Neuropathol Appl Neurobiol 34:23-32. 2008
    ....
  8. ncbi Olfactory tau pathology in Alzheimer disease and mild cognitive impairment
    J Attems
    Department of Pathology, Otto Wagner Hospital, Vienna, Austria
    Clin Neuropathol 25:265-71. 2006
    ..To examine the occurrence of tau pathology in the olfactory system in aged subjects and its relation to the severity of Alzheimer disease (AD) pathology...
  9. doi Correlations between cortical and subcortical tau pathology
    J Attems
    Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK Institute for Clinical Neurobiology, Vienna, Austria
    Neuropathol Appl Neurobiol 38:582-90. 2012
    ..In this study we correlate both olfactory and brainstem tau pathology with neuritic Braak stages...
  10. doi Cerebral amyloid angiopathy in Lewy body disease
    K A Jellinger
    Institute of Clinical Neurobiology, Vienna, Austria
    J Neural Transm 115:473-82. 2008
    ..This and other recent studies imply an association of CAA with cognitive decline in both PD/PDD and DLB, particularly in cases with concomitant AD-type pathology...
  11. ncbi Sporadic cerebral amyloid angiopathy is not a frequent cause of spontaneous brain hemorrhage
    K A Jellinger
    Institute of Clinical Neurobiology, Kenyongasse, Vienna, Austria
    Eur J Neurol 14:923-8. 2007
    ....
  12. ncbi Alzheimer's disease pathology influences severity and topographical distribution of cerebral amyloid angiopathy
    Johannes Attems
    Pathological Institute, Otto Wagner Hospital, Baumgartner Hohe 1, 1140, Vienna, Austria
    Acta Neuropathol 110:222-31. 2005
    ..01), and was independent of APOE genotype. Our results suggest that progressing AD pathology not only increases the severity of CAA, but also shifts its topographical distribution towards the occipital cortex...
  13. ncbi Only cerebral capillary amyloid angiopathy correlates with Alzheimer pathology--a pilot study
    Johannes Attems
    Institute of Pathology, Otto Wagner Hospital, Baumgartner Hoehe 1, 1140 Vienna, Austria
    Acta Neuropathol 107:83-90. 2004
    ..Studies to answer the question whether CapCAA represents an epiphenomenon or an indicator of a pathogenic association between tau cytopathology and Abeta deposition in capillaries are in progress...
  14. ncbi Unexpectedly low prevalence of intracerebral hemorrhages in sporadic cerebral amyloid angiopathy: an autopsy study
    Johannes Attems
    Institute of Pathology, Otto Wagner Hospital, Baumgartner Hoehe 1, 1145, Vienna, Austria
    J Neurol 255:70-6. 2008
    ..Hence, the role of APOE in the pathogenesis of ICH with and without CAA needs further elucidation...
  15. ncbi Neurofibrillary tangle-predominant dementia: comparison with classical Alzheimer disease
    K A Jellinger
    Institute of Clinical Neurobiology, 18, Kenyongasse, 1070, Vienna, Austria
    Acta Neuropathol 113:107-17. 2007
    ..Comparing 51 autopsy cases of NFTPD with 244 classical AD subjects, the nosology of NFTPD and its differences from AD are discussed...
  16. ncbi Prevalence and impact of cerebrovascular pathology in Alzheimer's disease and parkinsonism
    K A Jellinger
    Institute of Clinical Neurobiology, Vienna, Austria
    Acta Neurol Scand 114:38-46. 2006
    ..To study the prevalence and impact of cerebrovascular lesions (CVL) in Alzheimer's disease (AD) and their effects on cognitive impairment...
  17. ncbi Immunoreactivity of calcium binding protein secretagogin in the human hippocampus is restricted to pyramidal neurons
    Johannes Attems
    Institute of Pathology, Otto Wagner Hospital, Baumgartner Hoehe 1A 1145, Vienna, Austria
    Exp Gerontol 42:215-22. 2007
    ..The pattern of secretagogin immunoreactivity resembles that of calcium sensor proteins as it is restricted to a subset of neurons and therefore secretagogin could serve highly specialized tasks in neuronal calcium signalling...
  18. ncbi Catheter-related Leuconostoc bacteremia secondary to pulmonary Mycobacterium xenopi infection
    Monika Huber
    Pathologisch Bakteriologisches Institut, SMZ Otto Wagner Spital, Baumgartner Höhe, Vienna, Austria
    Wien Klin Wochenschr 119:674-7. 2007
    ..To our knowledge, this is the first report of a patient with Leuconostoc spp. infection secondary to pulmonary non-tuberculous mycobacteriosis...
  19. ncbi Alzheimer pathology in the olfactory bulb
    K A Jellinger
    Institute of Clinical Neurobiology, Vienna, Austria
    Neuropathol Appl Neurobiol 31:203. 2005
  20. ncbi Amyloid PET and MRI in Alzheimer's disease and mild cognitive impairment
    E Dimou
    Department of Nuclear Medicine, University Hospital, Vienna, Austria
    Curr Alzheimer Res 6:312-9. 2009
    ..In this paper we review the recent development of the molecular imaging technique PET and its different radiopharmaceuticals on the trail for imaging amyloid in AD and the conversion of MCI to AD...
  21. ncbi Prevalence of dementia disorders in the oldest-old: an autopsy study
    Kurt A Jellinger
    Institute of Clinical Neurobiology, Kenyongasse 18, 1070, Vienna, Austria
    Acta Neuropathol 119:421-33. 2010
    ....
  22. ncbi Olfactory involvement in aging and Alzheimer's disease: an autopsy study
    Johannes Attems
    Institute of Pathology, O Wagner Hospital, Vienna, Austria
    J Alzheimers Dis 7:149-57; discussion 173-80. 2005
    ..Since the involvement of both systems is associated with a high risk of cognitive decline, future studies should validate the sensitivity of olfactory mucosa biopsies in the diagnosis of Alzheimer's disease...
  23. ncbi Hippocampal sclerosis in Alzheimer disease and other dementias
    Johannes Attems
    Department of Pathology, Otto Wagner Hospital, Vienna, Austria
    Neurology 66:775. 2006
  24. doi Prevalence and impact of vascular and Alzheimer pathologies in Lewy body disease
    Kurt A Jellinger
    Institute of Clinical Neurobiology, Vienna, Austria
    Acta Neuropathol 115:427-36. 2008
    ....
  25. ncbi Unclassifiable tauopathy associated with an A152T variation in MAPT exon 7
    G G Kovacs
    Institute of Neurology, Medical University of Vienna, Vienna, Austria
    Clin Neuropathol 30:3-10. 2011
    ..Our observation of an apparently familial disorder with a novel neuropathological phenotype suggests a possible pathogenic role of this MAPT gene variation, which might be different from mutations affecting the microtubule binding...
  26. ncbi Lung disease 35 years after aspiration of activated charcoal in combination with pulmonary lymphangioleiomyomatosis. A histological and clinicopathological study with scanning electron microscopic evaluation and element analysis
    M Huber
    Otto Wagner Hospital, Institute of Pathology and Bacteriology, Baumgartner Hoehe 1, Vienna, Austria
    Virchows Arch 449:225-9. 2006
    ..To our knowledge, this is the first report not only on a long-term follow-up after aspiration of activated charcoal but also on charcoal-related pulmonary lesions in combination with LAM...
  27. ncbi Tau and alpha-synuclein brainstem pathology in Alzheimer disease: relation with extrapyramidal signs
    Johannes Attems
    Institute of Pathology, Otto Wagner Hospital, Vienna, Austria
    Acta Neuropathol 113:53-62. 2007
    ..However, often associated with nigral tau lesions and higher Braak stages, EPS in elderly patients may be a surrogate marker for severe neuritic AD pathology...
  28. ncbi Her-2/neu and EGFR tyrosine kinase activation predict the efficacy of trastuzumab-based therapy in patients with metastatic breast cancer
    Gernot Hudelist
    Ludwig Boltzmann Institute for Clinical and Experimental Oncology, Vienna, Austria
    Int J Cancer 118:1126-34. 2006
    ..We hypothesize that the activation state of both Her-2/neu and EGFR are key determinants for trastuzumab efficacy...
  29. ncbi Biomarkers for early diagnosis of Alzheimer disease: 'ALZheimer ASsociated gene'--a new blood biomarker?
    Kurt A Jellinger
    Institute of Clinical Neurobiology, Vienna, Austria
    J Cell Mol Med 12:1094-117. 2008
    ..It is suggested that ALZAS represents an indicator in a dynamic equilibrium between both peripheral and brain degenerative changes in AD and may become a useful "non-invasive" diagnostic marker via a simple blood test...
  30. ncbi Expression of TAU in insulin-secreting cells and its interaction with the calcium-binding protein secretagogin
    Magdalena Maj
    Department of Medicine III, Medical University of Vienna, Wahringer Gurtel 18 20, Vienna, Austria
    J Endocrinol 205:25-36. 2010
    ..Our findings demonstrated for the first time the association of TAU and the calcium-binding protein SCGN and support earlier results implicating that beta-cells might represent an extra cerebral site of tauopathy...
  31. ncbi Prevalence and pathogenic role of cerebrovascular lesions in Alzheimer disease
    Kurt A Jellinger
    Institute of Clinical Neurobiology, Kenyongasse 18, A 1070 Vienna, Austria
    J Neurol Sci 229:37-41. 2005
    ..Considering the variability of vascular pathology in both AD and aged brains, the mechanisms behind their interactions are largely unknown, and further studies are needed to clarify their impact on cognitive impairment...
  32. ncbi Does striatal pathology distinguish Parkinson disease with dementia and dementia with Lewy bodies?
    Kurt A Jellinger
    Institute of Clinical Neurobiology, Kenyongasse 18, 1070 Vienna, Austria
    Acta Neuropathol 112:253-60. 2006
    ..Differences in AS and Abeta pathologies and much less of tau lesions in the striatum support a morphologic distinction between PDD and DLB, which may be of pathophysiologic importance, but the causes of these differences are unclear...