Cheryl M Salome

Summary

Affiliation: Woolcock Institute of Medical Research
Country: Australia

Publications

  1. doi request reprint Physiology of obesity and effects on lung function
    Cheryl M Salome
    Woolcock Institute of Medical Research, P O Box M77, Missenden Rd NSW 2050, Australia
    J Appl Physiol (1985) 108:206-11. 2010
  2. pmc Perception of airway narrowing during reduction of inhaled corticosteroids and asthma exacerbation
    C M Salome
    Woolcock Institute of Medical Research formerly known as Institute of Respiratory Medicine, University of Sydney, NSW 2006, Australia
    Thorax 58:1042-7. 2003
  3. ncbi request reprint Effect of obesity on breathlessness and airway responsiveness to methacholine in non-asthmatic subjects
    C M Salome
    Woolcock Institute of Medical Research, Camperdown, New South Wales, Australia
    Int J Obes (Lond) 32:502-9. 2008
  4. ncbi request reprint Airway re-narrowing following deep inspiration in asthmatic and nonasthmatic subjects
    C M Salome
    Woolcock Institute of Medical Research and Cooperative Research Centre for Asthma, University of Sydney, Australia
    Eur Respir J 22:62-8. 2003
  5. doi request reprint Effect of methacholine on peripheral lung mechanics and ventilation heterogeneity in asthma
    Sue R Downie
    Woolcock Institute of Medical Research, Glebe, Sydney, New South Wales, Australia
    J Appl Physiol (1985) 114:770-7. 2013
  6. pmc Airway closure on imaging relates to airway hyperresponsiveness and peripheral airway disease in asthma
    Catherine E Farrow
    Woolcock Institute of Medical Research, Glebe, New South Wales, Australia
    J Appl Physiol (1985) 113:958-66. 2012
  7. ncbi request reprint Effects of methacholine on small airway function measured by forced oscillation technique and multiple breath nitrogen washout in normal subjects
    Gregory G King
    Woolcock Institute of Medical Research, Camperdown 2050, Australia
    Respir Physiol Neurobiol 148:165-77. 2005
  8. doi request reprint Obesity is a determinant of asthma control independent of inflammation and lung mechanics
    Claude S Farah
    Woolcock Institute of Medical Research, University of Sydney, Camperdown, NSW, 2050, Australia
    Chest 140:659-66. 2011
  9. doi request reprint Avoiding deep inspirations increases the maximal response to methacholine without altering sensitivity in non-asthmatics
    David G Chapman
    Woolcock Institute of Medical Research, PO Box M77 Missenden Road, Sydney, NSW 2050, Australia
    Respir Physiol Neurobiol 173:157-63. 2010
  10. doi request reprint Ventilation heterogeneity predicts asthma control in adults following inhaled corticosteroid dose titration
    Claude S Farah
    Airway Physiology Group, Woolcock Institute of Medical Research, Glebe, Australia
    J Allergy Clin Immunol 130:61-8. 2012

Collaborators

Detail Information

Publications50

  1. doi request reprint Physiology of obesity and effects on lung function
    Cheryl M Salome
    Woolcock Institute of Medical Research, P O Box M77, Missenden Rd NSW 2050, Australia
    J Appl Physiol (1985) 108:206-11. 2010
    ..Thus obesity has effects on lung function that can reduce respiratory well-being, even in the absence of specific respiratory disease, and may also exaggerate the effects of existing airway disease...
  2. pmc Perception of airway narrowing during reduction of inhaled corticosteroids and asthma exacerbation
    C M Salome
    Woolcock Institute of Medical Research formerly known as Institute of Respiratory Medicine, University of Sydney, NSW 2006, Australia
    Thorax 58:1042-7. 2003
    ..A study was undertaken to determine if the perception of airway narrowing changes during the reduction of inhaled corticosteroid (ICS) dose or during an asthma exacerbation...
  3. ncbi request reprint Effect of obesity on breathlessness and airway responsiveness to methacholine in non-asthmatic subjects
    C M Salome
    Woolcock Institute of Medical Research, Camperdown, New South Wales, Australia
    Int J Obes (Lond) 32:502-9. 2008
    ..Obesity reduces lung volumes, which can increase airway responsiveness, and increases resistive and elastic work of breathing, which can increase dyspnea...
  4. ncbi request reprint Airway re-narrowing following deep inspiration in asthmatic and nonasthmatic subjects
    C M Salome
    Woolcock Institute of Medical Research and Cooperative Research Centre for Asthma, University of Sydney, Australia
    Eur Respir J 22:62-8. 2003
    ....
  5. doi request reprint Effect of methacholine on peripheral lung mechanics and ventilation heterogeneity in asthma
    Sue R Downie
    Woolcock Institute of Medical Research, Glebe, Sydney, New South Wales, Australia
    J Appl Physiol (1985) 114:770-7. 2013
    ..By contrast, increases in resistance and frequency dependence of resistance were not related to ventilation heterogeneity or airway closure and were more indicative of changes in central airway caliber than of heterogeneity...
  6. pmc Airway closure on imaging relates to airway hyperresponsiveness and peripheral airway disease in asthma
    Catherine E Farrow
    Woolcock Institute of Medical Research, Glebe, New South Wales, Australia
    J Appl Physiol (1985) 113:958-66. 2012
    ..38). The extent of airway closure induced by methacholine inhalation in asthmatic subjects is greater with increasing peripheral airways disease, as measured by ventilation heterogeneity, and with worse AHR...
  7. ncbi request reprint Effects of methacholine on small airway function measured by forced oscillation technique and multiple breath nitrogen washout in normal subjects
    Gregory G King
    Woolcock Institute of Medical Research, Camperdown 2050, Australia
    Respir Physiol Neurobiol 148:165-77. 2005
    ..Scond is also related to lung size. We review the current state of knowledge of FOT and MBNW in obstructive lung diseases and discuss future research directions...
  8. doi request reprint Obesity is a determinant of asthma control independent of inflammation and lung mechanics
    Claude S Farah
    Woolcock Institute of Medical Research, University of Sydney, Camperdown, NSW, 2050, Australia
    Chest 140:659-66. 2011
    ....
  9. doi request reprint Avoiding deep inspirations increases the maximal response to methacholine without altering sensitivity in non-asthmatics
    David G Chapman
    Woolcock Institute of Medical Research, PO Box M77 Missenden Road, Sydney, NSW 2050, Australia
    Respir Physiol Neurobiol 173:157-63. 2010
    ....
  10. doi request reprint Ventilation heterogeneity predicts asthma control in adults following inhaled corticosteroid dose titration
    Claude S Farah
    Airway Physiology Group, Woolcock Institute of Medical Research, Glebe, Australia
    J Allergy Clin Immunol 130:61-8. 2012
    ..However, the physiological determinants of asthma symptom control are poorly understood and spirometry is a poor predictor of symptomatic response...
  11. doi request reprint The role of the small airways in the clinical expression of asthma in adults
    Claude S Farah
    Woolcock Institute of Medical Research, Glebe, Australia
    J Allergy Clin Immunol 129:381-7, 387.e1. 2012
    ....
  12. doi request reprint Deep inspirations protect against airway closure in nonasthmatic subjects
    David G Chapman
    Woolcock Institute of Medical Research, Cooperative Research Centre for Asthma, University of Sydney, P O Box M77 Missenden Rd, Sydney, NSW 2050, Australia
    J Appl Physiol (1985) 107:564-9. 2009
    ..The protective effect of DI on FEV1 and FVC was abolished by expiration to residual volume. We speculate that the reduced airway closure is due to reduced baseline ventilation heterogeneity and/or reduced airway surface tension...
  13. ncbi request reprint Short-term variability of airway caliber-a marker of asthma?
    Chantale Diba
    The Woolcock Institute of Medical Research, Camperdown, New South Wales, Australia
    J Appl Physiol (1985) 103:296-304. 2007
    ..Our findings suggest that, using standard methods for forced oscillometry, impedance variability does not provide clinically useful information about the severity of asthma...
  14. pmc Ventilation heterogeneity is a major determinant of airway hyperresponsiveness in asthma, independent of airway inflammation
    Sue R Downie
    Woolcock Institute of Medical Research, Camperdown, NSW 2050, Australia
    Thorax 62:684-9. 2007
    ....
  15. doi request reprint Improved respiratory system conductance following bronchodilator predicts reduced exertional dyspnoea
    Chantale Diba
    The Woolcock Institute of Medical Research, Camperdown, Sydney, NSW 2050, Australia
    Respir Med 105:1345-51. 2011
    ..The relationship between these improvements in lung mechanics and improvements in functional outcomes, such as exertional dyspnoea, following bronchodilator, in COPD is unknown...
  16. ncbi request reprint The relationship between airflow obstruction, emphysema extent, and small airways function in COPD
    Sophie C Timmins
    Woolcock Institute of Medical Research, Australia
    Chest 142:312-9. 2012
    ..We hypothesized that small airways disease and emphysema extent contribute independently to the severity of both COPD and airflow obstruction...
  17. ncbi request reprint Airway distensibility in adults with asthma and healthy adults, measured by forced oscillation technique
    Nathan J Brown
    Woolcock Institute of Medical Research, P O Box M77, Missenden Road, Camperdown, NSW, 2050 Australia
    Am J Respir Crit Care Med 176:129-37. 2007
    ..Reduced airway distensibility in subjects with asthma compared with control subjects may be related to differences in lung elastic recoil and bronchomotor tone...
  18. ncbi request reprint A single high dose of inhaled corticosteroids: a possible treatment of asthma exacerbations
    Jorg D Leuppi
    Institute of Respiratory Medicine, University of Sydney, Australia
    Swiss Med Wkly 132:7-11. 2002
    ..However airway responsiveness and sputum eosinophils can be reduced within 6 hours by a single dose of inhaled corticosteroids...
  19. doi request reprint Predictors of airway hyperresponsiveness differ between old and young patients with asthma
    Kate M Hardaker
    Woolcock Institute of Medical Research, Glebe, NSW, Australia
    Chest 139:1395-401. 2011
    ..The aim of this study was to determine if the pathophysiologic predictors of AHR, including inflammation, ventilation heterogeneity, and airway closure, differed between young and old patients with asthma...
  20. doi request reprint Cut-points for response to mannitol challenges using the forced oscillation technique
    Melissa A McClean
    Woolcock Institute of Medical Research, Glebe, NSW, Australia
    Respir Med 105:533-40. 2011
    ..Adjusting for lung volume does not alter the ability of these variables to detect a positive response or the repeatability of the measurement...
  21. doi request reprint The dynamic face of respiratory research: understanding the effect of airway disease on a lung in constant motion
    David G Chapman
    Woolcock Institute of Medical Research, Missenden Road, Sydney, NSW 2050, Australia
    Pulm Pharmacol Ther 24:505-12. 2011
    ..As such, determining the pathophysiology responsible for the malfunction of deep inspirations in asthma remains critical to understanding the disease and is likely to pave the way for novel therapeutic targets...
  22. pmc Asthma and atopy in overweight children
    L M Schachter
    Woolcock Institute, University of Sydney, Sydney, NSW 2006, Australia
    Thorax 58:1031-5. 2003
    ..Obesity may be associated with an increase in asthma and atopy in children. If so, the effect could be due to an effect of obesity on lung volume and thus airway hyperresponsiveness...
  23. doi request reprint Does increased baseline ventilation heterogeneity following chest wall strapping predispose to airway hyperresponsiveness?
    David G Chapman
    Woolcock Institute of Medical Research, Sydney, New South Wales, Australia
    J Appl Physiol (1985) 113:25-30. 2012
    ..55, P = 0.02). This suggests that changes in baseline ventilation heterogeneity in healthy subjects are sufficient to increase airway responsiveness, independent of the presence of disease pathology...
  24. doi request reprint Asthma and obesity: a known association but unknown mechanism
    Claude S Farah
    The Woolcock Institute of Medical Research, Cooperative Research Centre for Asthma and Airways, Glebe, and the University of Sydney, Sydney, New South Wales, Australia
    Respirology 17:412-21. 2012
    ..An understanding of the various physiological perturbations that might be contributing to symptoms in obese patients with asthma will allow for a more targeted and rational treatment approach for these patients...
  25. doi request reprint Effect of deep inspiration avoidance on ventilation heterogeneity and airway responsiveness in healthy adults
    David G Chapman
    Woolcock Institute of Medical Research, Sydney, New South Wales, Australia
    J Appl Physiol (1985) 110:1400-5. 2011
    ..We speculate that DI avoidance reduces surfactant release, which increases peripheral ventilation heterogeneity and also predisposes to peripheral airway closure...
  26. ncbi request reprint A comparison of two methods for measuring airway distensibility: nitrogen washout and the forced oscillation technique
    Nathan J Brown
    The Woolcock Institute of Medical Research, PO Box M77, Camperdown, NSW 2050, Australia
    Physiol Meas 25:1067-75. 2004
    ..However, further studies are required to make any specific inferences about the relationship between airway distensibility by FOT and airway remodelling...
  27. doi request reprint Deep inspiration volume and the impaired reversal of bronchoconstriction in asthma
    Kathryn M Hulme
    Medical School, University of Sydney, NSW 2006, Australia
    Respir Physiol Neurobiol 189:506-12. 2013
    ..These findings suggest that the failure to reverse bronchoconstriction with DI in asthma is not due to reduced maximal dilatation, but rather due to increased airway narrowing during expiration. ..
  28. doi request reprint Mechanisms of airway hyperresponsiveness in asthma
    Norbert Berend
    Woolcock Institute of Medical Research, University of Sydney, CRC for Asthma and Airways, Sydney, NSW, Australia
    Respirology 13:624-31. 2008
    ..There is now evidence for a close relationship between ventilation heterogeneity and AHR which could be exploited clinically...
  29. ncbi request reprint Modeling airway resistance dynamics after tidal and deep inspirations
    C William Thorpe
    Woolcock Institute of Medical Research, Camperdown, NSW 2050, Australia
    J Appl Physiol (1985) 97:1643-53. 2004
    ..66. This suggests that the same time-dependent factors determine renarrowing after both large and small breaths...
  30. ncbi request reprint Markers of airway inflammation and airway hyperresponsiveness in patients with well-controlled asthma
    J D Leuppi
    Institute of Respiratory Medicine, University of Sydney, New South Wales, Australia
    Eur Respir J 18:444-50. 2001
    ..Airway hyperresponsiveness in clinically well-controlled asthmatics appears to be independent of eosinophilic airway inflammation...
  31. ncbi request reprint Predictive markers of asthma exacerbation during stepwise dose reduction of inhaled corticosteroids
    J D Leuppi
    Institute of Respiratory Medicine, University of Sydney, New South Wales, Australia
    Am J Respir Crit Care Med 163:406-12. 2001
    ..These findings suggest that documentation of patient's AHR or sputum eosinophils may be useful in guiding the reduction of ICS doses...
  32. pmc Obesity is a risk for asthma and wheeze but not airway hyperresponsiveness
    L M Schachter
    Institute of Respiratory Medicine, University of Sydney, Sydney, NSW 2006, Australia
    Thorax 56:4-8. 2001
    ....
  33. doi request reprint The feasibility of home monitoring of impedance with the forced oscillation technique in chronic obstructive pulmonary disease subjects
    Sophie C Timmins
    The Woolcock Institute of Medical Research, PO Box M77, Missenden Road, NSW 2037, Australia
    Physiol Meas 34:67-81. 2013
    ..The day-to-day variability of FOT measurements was similar to that of supervised laboratory recordings. These results support the conduct of larger, longer-term studies of FOT monitoring in COPD...
  34. ncbi request reprint Effect of budesonide on the perception of induced airway narrowing in subjects with asthma
    Cheryl M Salome
    Institute of Respiratory Medicine, University of Sydney, Sydney, New South Wales, Australia
    Am J Respir Crit Care Med 165:15-21. 2002
    ..We conclude that treatment with budesonide enhances the perception of airway narrowing, but the effect is unrelated to budesonide dose, or to changes in circulating eosinophil markers...
  35. doi request reprint Reference equations for respiratory system resistance and reactance in adults
    Nathan J Brown
    The Woolcock Institute of Medical Research, Glebe, NSW, Australia
    Respir Physiol Neurobiol 172:162-8. 2010
    ..To determine reference equations for respiratory system resistance and reactance in a large randomly selected sample from a general, predominantly Caucasian population...
  36. ncbi request reprint The effects of body weight on airway calibre
    G G King
    Woolcock Institute of Medical Research, Dept of Respiratory Medicine, Royal North Shore Hospital, Pacific Highway, St Leonards 2065, Australia
    Eur Respir J 25:896-901. 2005
    ..However, in males, airway narrowing is greater than that due to reduced lung volume alone. The mechanisms causing airway narrowing and sex differences in obesity are unknown...
  37. doi request reprint Increased airway closure is a determinant of airway hyperresponsiveness
    D G Chapman
    Woolcock Institute of Medical Research, Box M77 Missenden Rd PO, Camperdown NSW 2050 Australia
    Eur Respir J 32:1563-9. 2008
    ..However, after adjusting for airway closure, obesity appears to protect against airway hyperresponsiveness...
  38. pmc Exhaled nitric oxide levels in atopic children: relation to specific allergic sensitisation, AHR, and respiratory symptoms
    J D Leuppi
    Institute of Respiratory Medicine, University of Sydney, Australia
    Thorax 57:518-23. 2002
    ....
  39. doi request reprint Relationship between airway pathophysiology and airway inflammation in older asthmatics
    Celeste M Porsbjerg
    Respiratory Research Unit, Department of Respiratory Medicine, Bispebjerg Hospital, Copenhagen, Denmark Department of Respiratory and Sleep Medicine, John Hunter Hospital, Newcastle, New South Wales, Australia
    Respirology 18:1128-34. 2013
    ..We hypothesized that in older adult patients with asthma, neutrophil airway inflammation increases airway closure during bronchoconstriction, while eosinophil airway inflammation increases airway hyperresponsiveness (AHR)...
  40. doi request reprint Obesity, expiratory flow limitation and asthma symptoms
    Sriram Mahadev
    Woolcock Institute of Medical Research, 431 Glebe Pt Rd, Glebe, NSW 2037, Australia
    Pulm Pharmacol Ther 26:438-43. 2013
    ....
  41. pmc Prevalence of asthma and allergy in schoolchildren in Belmont, Australia: three cross sectional surveys over 20 years
    Brett G Toelle
    University of Sydney, Woolcock Institute of Medical Research, Box M77 Missenden Road Post Office, Camperdown, NSW 2050, Australia
    BMJ 328:386-7. 2004
  42. ncbi request reprint Eosinophilia, interleukin-5, and tumour necrosis factor-alpha in asthmatic children
    J M Hughes
    Faculty of Pharmacy, University of Sydney, Sydney, Australia
    Allergy 56:412-8. 2001
    ..This study confirms that eosinophilia is the index of inflammation that is most closely related to the clinical severity of childhood asthma...
  43. ncbi request reprint Asthma and allergy associated with occupational exposure to ispaghula and senna products in a pharmaceutical work force
    G B Marks
    Institute of Respiratory Medicine, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia
    Am Rev Respir Dis 144:1065-9. 1991
    ..Sensitization to ispaghula and/or senna was not a risk factor for asthma. An IgE-mediated allergic mechanism is probably responsible for the allergic symptoms in many of these subjects. Smoking seems to be a cofactor in this process...
  44. ncbi request reprint Differences in airway closure between normal and asthmatic subjects measured with single-photon emission computed tomography and technegas
    G G King
    Institute of Respiratory Medicine and Department of Medicine, University of Sydney, Australia
    Am J Respir Crit Care Med 158:1900-6. 1998
    ..This pattern is lost in asthmatic subjects. This may be explained by an increased range of closing pressures and a patchy distribution of airway closure, probably secondary to allergic inflammation...
  45. ncbi request reprint Association between nasal and bronchial symptoms in subjects with persistent allergic rhinitis
    S R Downie
    Woolcock Institute of Medical Research, Camperdown, Sydney, Australia
    Allergy 59:320-6. 2004
    ..The association between nasal and bronchial symptoms, and the course of bronchial responsiveness and airway inflammation in house dust mite sensitive persistent rhinitis over a prolonged time period has not been thoroughly explored...
  46. ncbi request reprint Symptoms of persistent allergic rhinitis during a full calendar year in house dust mite-sensitive subjects
    S R Downie
    Woolcock Institute of Medical Research, Camperdown, Sydney, Australia
    Allergy 59:406-14. 2004
    ..Little is known about the natural course of persistent rhinitis symptoms over a prolonged period...
  47. ncbi request reprint Repeatability of peak nasal inspiratory flow measurements and utility for assessing the severity of rhinitis
    R Starling-Schwanz
    Woolcock Institute of Medical Research, University of Sydney, New South Wales, Australia
    Allergy 60:795-800. 2005
    ..Therefore, this study aimed to evaluate the repeatability of PNIF measurements and to assess their association with the signs and symptoms of rhinitis...
  48. pmc Inhaled corticosteroid dosage in asthma
    H K Reddel
    Thorax 57:837-8; author reply 838. 2002
  49. pmc Sahaja yoga in the management of moderate to severe asthma: a randomised controlled trial
    R Manocha
    Natural Therapies Unit, Royal Hospital for Women, NSW, Australia
    Thorax 57:110-5. 2002
    ..A study was undertaken to assess the effectiveness of this therapy as an adjunctive tool in the management of asthma in adult patients who remained symptomatic on moderate to high doses of inhaled steroids...
  50. ncbi request reprint Multimodality measurements of small airways disease
    G G King
    Eur Respir J 27:250-2. 2006