Research Topics
| Cheryl M SalomeSummaryAffiliation: Woolcock Institute of Medical Research Country: Australia Publications
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Detail Information
Publications
Perception of airway narrowing during reduction of inhaled corticosteroids and asthma exacerbationC M Salome
Woolcock Institute of Medical Research formerly known as Institute of Respiratory Medicine, University of Sydney, NSW 2006, Australia
Thorax 58:1042-7. 2003..A study was undertaken to determine if the perception of airway narrowing changes during the reduction of inhaled corticosteroid (ICS) dose or during an asthma exacerbation...
Physiology of obesity and effects on lung functionCheryl M Salome
Woolcock Institute of Medical Research, P O Box M77, Missenden Rd NSW 2050, Australia
J Appl Physiol 108:206-11. 2010..Thus obesity has effects on lung function that can reduce respiratory well-being, even in the absence of specific respiratory disease, and may also exaggerate the effects of existing airway disease...
Airway re-narrowing following deep inspiration in asthmatic and nonasthmatic subjectsC M Salome
Woolcock Institute of Medical Research and Cooperative Research Centre for Asthma, University of Sydney, Australia
Eur Respir J 22:62-8. 2003....- Effect of obesity on breathlessness and airway responsiveness to methacholine in non-asthmatic subjectsC M Salome
Woolcock Institute of Medical Research, Camperdown, New South Wales, Australia
Int J Obes (Lond) 32:502-9. 2008..Obesity reduces lung volumes, which can increase airway responsiveness, and increases resistive and elastic work of breathing, which can increase dyspnea... - Airway closure on imaging relates to airway hyperresponsiveness and peripheral airway disease in asthmaCatherine E Farrow
Woolcock Institute of Medical Research, Glebe, New South Wales, Australia
J Appl Physiol 113:958-66. 2012..38). The extent of airway closure induced by methacholine inhalation in asthmatic subjects is greater with increasing peripheral airways disease, as measured by ventilation heterogeneity, and with worse AHR... - Effects of methacholine on small airway function measured by forced oscillation technique and multiple breath nitrogen washout in normal subjectsGregory G King
Woolcock Institute of Medical Research, Camperdown 2050, Australia
Respir Physiol Neurobiol 148:165-77. 2005..Scond is also related to lung size. We review the current state of knowledge of FOT and MBNW in obstructive lung diseases and discuss future research directions... - Obesity is a determinant of asthma control independent of inflammation and lung mechanicsClaude S Farah
Woolcock Institute of Medical Research, University of Sydney, Camperdown, NSW, 2050, Australia
Chest 140:659-66. 2011.... - Avoiding deep inspirations increases the maximal response to methacholine without altering sensitivity in non-asthmaticsDavid G Chapman
Woolcock Institute of Medical Research, PO Box M77 Missenden Road, Sydney, NSW 2050, Australia
Respir Physiol Neurobiol 173:157-63. 2010.... - Ventilation heterogeneity predicts asthma control in adults following inhaled corticosteroid dose titrationClaude S Farah
Airway Physiology Group, Woolcock Institute of Medical Research, Glebe, Australia
J Allergy Clin Immunol 130:61-8. 2012..However, the physiological determinants of asthma symptom control are poorly understood and spirometry is a poor predictor of symptomatic response... - The role of the small airways in the clinical expression of asthma in adultsClaude S Farah
Woolcock Institute of Medical Research, Glebe, Australia
J Allergy Clin Immunol 129:381-7, 387.e1. 2012.... - Deep inspirations protect against airway closure in nonasthmatic subjectsDavid G Chapman
Woolcock Institute of Medical Research, Cooperative Research Centre for Asthma, University of Sydney, P O Box M77 Missenden Rd, Sydney, NSW 2050, Australia
J Appl Physiol 107:564-9. 2009..The protective effect of DI on FEV1 and FVC was abolished by expiration to residual volume. We speculate that the reduced airway closure is due to reduced baseline ventilation heterogeneity and/or reduced airway surface tension... - Ventilation heterogeneity is a major determinant of airway hyperresponsiveness in asthma, independent of airway inflammationSue R Downie
Woolcock Institute of Medical Research, Camperdown, NSW 2050, Australia
Thorax 62:684-9. 2007.... - Short-term variability of airway caliber-a marker of asthma?Chantale Diba
The Woolcock Institute of Medical Research, Camperdown, New South Wales, Australia
J Appl Physiol 103:296-304. 2007..Our findings suggest that, using standard methods for forced oscillometry, impedance variability does not provide clinically useful information about the severity of asthma... - Improved respiratory system conductance following bronchodilator predicts reduced exertional dyspnoeaChantale Diba
The Woolcock Institute of Medical Research, Camperdown, Sydney, NSW 2050, Australia
Respir Med 105:1345-51. 2011..The relationship between these improvements in lung mechanics and improvements in functional outcomes, such as exertional dyspnoea, following bronchodilator, in COPD is unknown... - The relationship between airflow obstruction, emphysema extent, and small airways function in COPDSophie C Timmins
Woolcock Institute of Medical Research, Australia
Chest 142:312-9. 2012..We hypothesized that small airways disease and emphysema extent contribute independently to the severity of both COPD and airflow obstruction... - Airway distensibility in adults with asthma and healthy adults, measured by forced oscillation techniqueNathan J Brown
Woolcock Institute of Medical Research, P O Box M77, Missenden Road, Camperdown, NSW, 2050 Australia
Am J Respir Crit Care Med 176:129-37. 2007..Reduced airway distensibility in subjects with asthma compared with control subjects may be related to differences in lung elastic recoil and bronchomotor tone... - A single high dose of inhaled corticosteroids: a possible treatment of asthma exacerbationsJorg D Leuppi
Institute of Respiratory Medicine, University of Sydney, Australia
Swiss Med Wkly 132:7-11. 2002..However airway responsiveness and sputum eosinophils can be reduced within 6 hours by a single dose of inhaled corticosteroids... - Predictors of airway hyperresponsiveness differ between old and young patients with asthmaKate M Hardaker
Woolcock Institute of Medical Research, Glebe, NSW, Australia
Chest 139:1395-401. 2011..The aim of this study was to determine if the pathophysiologic predictors of AHR, including inflammation, ventilation heterogeneity, and airway closure, differed between young and old patients with asthma... - Cut-points for response to mannitol challenges using the forced oscillation techniqueMelissa A McClean
Woolcock Institute of Medical Research, Glebe, NSW, Australia
Respir Med 105:533-40. 2011..Adjusting for lung volume does not alter the ability of these variables to detect a positive response or the repeatability of the measurement... - The dynamic face of respiratory research: understanding the effect of airway disease on a lung in constant motionDavid G Chapman
Woolcock Institute of Medical Research, Missenden Road, Sydney, NSW 2050, Australia
Pulm Pharmacol Ther 24:505-12. 2011..As such, determining the pathophysiology responsible for the malfunction of deep inspirations in asthma remains critical to understanding the disease and is likely to pave the way for novel therapeutic targets... - Asthma and atopy in overweight childrenL M Schachter
Woolcock Institute, University of Sydney, Sydney, NSW 2006, Australia
Thorax 58:1031-5. 2003..Obesity may be associated with an increase in asthma and atopy in children. If so, the effect could be due to an effect of obesity on lung volume and thus airway hyperresponsiveness... - Does increased baseline ventilation heterogeneity following chest wall strapping predispose to airway hyperresponsiveness?David G Chapman
Woolcock Institute of Medical Research, Sydney, New South Wales, Australia
J Appl Physiol 113:25-30. 2012..55, P = 0.02). This suggests that changes in baseline ventilation heterogeneity in healthy subjects are sufficient to increase airway responsiveness, independent of the presence of disease pathology... - Asthma and obesity: a known association but unknown mechanismClaude S Farah
The Woolcock Institute of Medical Research, Cooperative Research Centre for Asthma and Airways, Glebe, and the University of Sydney, Sydney, New South Wales, Australia
Respirology 17:412-21. 2012..An understanding of the various physiological perturbations that might be contributing to symptoms in obese patients with asthma will allow for a more targeted and rational treatment approach for these patients... - Effect of deep inspiration avoidance on ventilation heterogeneity and airway responsiveness in healthy adultsDavid G Chapman
Woolcock Institute of Medical Research, Sydney, New South Wales, Australia
J Appl Physiol 110:1400-5. 2011..We speculate that DI avoidance reduces surfactant release, which increases peripheral ventilation heterogeneity and also predisposes to peripheral airway closure... - A comparison of two methods for measuring airway distensibility: nitrogen washout and the forced oscillation techniqueNathan J Brown
The Woolcock Institute of Medical Research, PO Box M77, Camperdown, NSW 2050, Australia
Physiol Meas 25:1067-75. 2004..However, further studies are required to make any specific inferences about the relationship between airway distensibility by FOT and airway remodelling... - Mechanisms of airway hyperresponsiveness in asthmaNorbert Berend
Woolcock Institute of Medical Research, University of Sydney, CRC for Asthma and Airways, Sydney, NSW, Australia
Respirology 13:624-31. 2008..There is now evidence for a close relationship between ventilation heterogeneity and AHR which could be exploited clinically... - Modeling airway resistance dynamics after tidal and deep inspirationsC William Thorpe
Woolcock Institute of Medical Research, Camperdown, NSW 2050, Australia
J Appl Physiol 97:1643-53. 2004..66. This suggests that the same time-dependent factors determine renarrowing after both large and small breaths... - Markers of airway inflammation and airway hyperresponsiveness in patients with well-controlled asthmaJ D Leuppi
Institute of Respiratory Medicine, University of Sydney, New South Wales, Australia
Eur Respir J 18:444-50. 2001..Airway hyperresponsiveness in clinically well-controlled asthmatics appears to be independent of eosinophilic airway inflammation... - Obesity is a risk for asthma and wheeze but not airway hyperresponsivenessL M Schachter
Institute of Respiratory Medicine, University of Sydney, Sydney, NSW 2006, Australia
Thorax 56:4-8. 2001.... - Predictive markers of asthma exacerbation during stepwise dose reduction of inhaled corticosteroidsJ D Leuppi
Institute of Respiratory Medicine, University of Sydney, New South Wales, Australia
Am J Respir Crit Care Med 163:406-12. 2001..These findings suggest that documentation of patient's AHR or sputum eosinophils may be useful in guiding the reduction of ICS doses... - Effect of methacholine on peripheral lung mechanics and ventilation heterogeneity in asthmaSue R Downie
Woolcock Institute of Medical Research, Glebe, Sydney, New South Wales, Australia
J Appl Physiol 114:770-7. 2013..By contrast, increases in resistance and frequency dependence of resistance were not related to ventilation heterogeneity or airway closure and were more indicative of changes in central airway caliber than of heterogeneity... - The feasibility of home monitoring of impedance with the forced oscillation technique in chronic obstructive pulmonary disease subjectsSophie C Timmins
The Woolcock Institute of Medical Research, PO Box M77, Missenden Road, NSW 2037, Australia
Physiol Meas 34:67-81. 2013..The day-to-day variability of FOT measurements was similar to that of supervised laboratory recordings. These results support the conduct of larger, longer-term studies of FOT monitoring in COPD... - Effect of budesonide on the perception of induced airway narrowing in subjects with asthmaCheryl M Salome
Institute of Respiratory Medicine, University of Sydney, Sydney, New South Wales, Australia
Am J Respir Crit Care Med 165:15-21. 2002..We conclude that treatment with budesonide enhances the perception of airway narrowing, but the effect is unrelated to budesonide dose, or to changes in circulating eosinophil markers... - Reference equations for respiratory system resistance and reactance in adultsNathan J Brown
The Woolcock Institute of Medical Research, Glebe, NSW, Australia
Respir Physiol Neurobiol 172:162-8. 2010..To determine reference equations for respiratory system resistance and reactance in a large randomly selected sample from a general, predominantly Caucasian population... - The effects of body weight on airway calibreG G King
Woolcock Institute of Medical Research, Dept of Respiratory Medicine, Royal North Shore Hospital, Pacific Highway, St Leonards 2065, Australia
Eur Respir J 25:896-901. 2005..However, in males, airway narrowing is greater than that due to reduced lung volume alone. The mechanisms causing airway narrowing and sex differences in obesity are unknown... - Exhaled nitric oxide levels in atopic children: relation to specific allergic sensitisation, AHR, and respiratory symptomsJ D Leuppi
Institute of Respiratory Medicine, University of Sydney, Australia
Thorax 57:518-23. 2002.... - Increased airway closure is a determinant of airway hyperresponsivenessD G Chapman
Woolcock Institute of Medical Research, Box M77 Missenden Rd PO, Camperdown NSW 2050 Australia
Eur Respir J 32:1563-9. 2008..However, after adjusting for airway closure, obesity appears to protect against airway hyperresponsiveness... - Prevalence of asthma and allergy in schoolchildren in Belmont, Australia: three cross sectional surveys over 20 yearsBrett G Toelle
University of Sydney, Woolcock Institute of Medical Research, Box M77 Missenden Road Post Office, Camperdown, NSW 2050, Australia
BMJ 328:386-7. 2004 - Differences in airway closure between normal and asthmatic subjects measured with single-photon emission computed tomography and technegasG G King
Institute of Respiratory Medicine and Department of Medicine, University of Sydney, Australia
Am J Respir Crit Care Med 158:1900-6. 1998..This pattern is lost in asthmatic subjects. This may be explained by an increased range of closing pressures and a patchy distribution of airway closure, probably secondary to allergic inflammation... - Asthma and allergy associated with occupational exposure to ispaghula and senna products in a pharmaceutical work forceG B Marks
Institute of Respiratory Medicine, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia
Am Rev Respir Dis 144:1065-9. 1991..Sensitization to ispaghula and/or senna was not a risk factor for asthma. An IgE-mediated allergic mechanism is probably responsible for the allergic symptoms in many of these subjects. Smoking seems to be a cofactor in this process... - Eosinophilia, interleukin-5, and tumour necrosis factor-alpha in asthmatic childrenJ M Hughes
Faculty of Pharmacy, University of Sydney, Sydney, Australia
Allergy 56:412-8. 2001..This study confirms that eosinophilia is the index of inflammation that is most closely related to the clinical severity of childhood asthma... - Association between nasal and bronchial symptoms in subjects with persistent allergic rhinitisS R Downie
Woolcock Institute of Medical Research, Camperdown, Sydney, Australia
Allergy 59:320-6. 2004..Persistent rhinitic subjects were more at risk than healthy adults of bronchial symptoms and airway inflammation, which are likely risk factors for asthma... - Repeatability of peak nasal inspiratory flow measurements and utility for assessing the severity of rhinitisR Starling-Schwanz
Woolcock Institute of Medical Research, University of Sydney, New South Wales, Australia
Allergy 60:795-800. 2005..The PNIF provides information that is qualitatively different to that provided by symptom scores and may be useful to measure the extent of nasal obstruction... - Symptoms of persistent allergic rhinitis during a full calendar year in house dust mite-sensitive subjectsS R Downie
Woolcock Institute of Medical Research, Camperdown, Sydney, Australia
Allergy 59:406-14. 2004..An increase in nasal symptom score increased the likelihood of nasal medication use. These findings help to characterize the course of persistent rhinitis over a previously unstudied period of 1 year... - Sahaja yoga in the management of moderate to severe asthma: a randomised controlled trialR Manocha
Natural Therapies Unit, Royal Hospital for Women, NSW, Australia
Thorax 57:110-5. 2002..Further work is required to understand the mechanism underlying the observed effects and to establish whether elements of this intervention may be clinically valuable in patients with severe asthma... - Inhaled corticosteroid dosage in asthmaH K Reddel
Thorax 57:837-8; author reply 838. 2002 - Multimodality measurements of small airways diseaseG G King
Eur Respir J 27:250-2. 2006