G G King

Summary

Affiliation: Woolcock Institute of Medical Research
Country: Australia

Publications

  1. ncbi request reprint Heterogeneity of narrowing in normal and asthmatic airways measured by HRCT
    G G King
    University of British Columbia, James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St Paul s Hospital, Sydney, Australia
    Eur Respir J 24:211-8. 2004
  2. ncbi request reprint A comparison of two methods for measuring airway distensibility: nitrogen washout and the forced oscillation technique
    Nathan J Brown
    The Woolcock Institute of Medical Research, PO Box M77, Camperdown, NSW 2050, Australia
    Physiol Meas 25:1067-75. 2004
  3. doi request reprint V/Q SPECT: utility for investigation of pulmonary physiology
    Gregory G King
    Woolcock Institute of Medical Research, Sydney, NSW, Australia University of Sydney, Sydney, NSW, Australia
    Semin Nucl Med 40:467-73. 2010
  4. ncbi request reprint Tomographic imaging of small airways
    Gregory G King
    Woolcock Institute of Medical Research, Glebe, N S W, Department of Respiratory Medicine, Royal North Shore Hospital, St Leonards, N S W, Australia
    Respiration 84:265-74. 2012
  5. pmc Is low dose inhaled corticosteroid therapy as effective for inflammation and remodeling in asthma? A randomized, parallel group study
    Melissa Baraket
    Woolcock Institute of Medical Research, Sydney, NSW, Australia
    Respir Res 13:11. 2012
  6. ncbi request reprint Effects of methacholine on small airway function measured by forced oscillation technique and multiple breath nitrogen washout in normal subjects
    Gregory G King
    Woolcock Institute of Medical Research, Camperdown 2050, Australia
    Respir Physiol Neurobiol 148:165-77. 2005
  7. doi request reprint Cutting edge technologies in respiratory research: lung function testing
    Gregory G King
    Woolcock Institute of Medical Research, The Northern Clinical School, Sydney Medical School, University of Sydney, New South Wales, Australia
    Respirology 16:883-90. 2011
  8. doi request reprint Current and emerging imaging in relation to drug discovery in airways disease
    Gregory G King
    The Woolcock Institute of Medical Research, Sydney, NSW 2037, Australia
    Pulm Pharmacol Ther 24:497-504. 2011
  9. ncbi request reprint The effects of body weight on airway calibre
    G G King
    Woolcock Institute of Medical Research, Dept of Respiratory Medicine, Royal North Shore Hospital, Pacific Highway, St Leonards 2065, Australia
    Eur Respir J 25:896-901. 2005
  10. ncbi request reprint Effect of obesity on breathlessness and airway responsiveness to methacholine in non-asthmatic subjects
    C M Salome
    Woolcock Institute of Medical Research, Camperdown, New South Wales, Australia
    Int J Obes (Lond) 32:502-9. 2008

Detail Information

Publications33

  1. ncbi request reprint Heterogeneity of narrowing in normal and asthmatic airways measured by HRCT
    G G King
    University of British Columbia, James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St Paul s Hospital, Sydney, Australia
    Eur Respir J 24:211-8. 2004
    ..Airway narrowing is heterogeneous in the large airways of asthmatics and normals, being greater in asthmatics...
  2. ncbi request reprint A comparison of two methods for measuring airway distensibility: nitrogen washout and the forced oscillation technique
    Nathan J Brown
    The Woolcock Institute of Medical Research, PO Box M77, Camperdown, NSW 2050, Australia
    Physiol Meas 25:1067-75. 2004
    ..However, further studies are required to make any specific inferences about the relationship between airway distensibility by FOT and airway remodelling...
  3. doi request reprint V/Q SPECT: utility for investigation of pulmonary physiology
    Gregory G King
    Woolcock Institute of Medical Research, Sydney, NSW, Australia University of Sydney, Sydney, NSW, Australia
    Semin Nucl Med 40:467-73. 2010
    ..There has been relatively little published in this area but there is great potential for advances in the understanding of airways disease to be gained from SPECT imaging...
  4. ncbi request reprint Tomographic imaging of small airways
    Gregory G King
    Woolcock Institute of Medical Research, Glebe, N S W, Department of Respiratory Medicine, Royal North Shore Hospital, St Leonards, N S W, Australia
    Respiration 84:265-74. 2012
    ..e. spatial distribution. Their utility is magnified when combined with other information such as lung function. In this article, the application of topographic imaging in relation to small airway function is discussed...
  5. pmc Is low dose inhaled corticosteroid therapy as effective for inflammation and remodeling in asthma? A randomized, parallel group study
    Melissa Baraket
    Woolcock Institute of Medical Research, Sydney, NSW, Australia
    Respir Res 13:11. 2012
    ..Although symptom/lung function response to low and high dose ICS medication is comparable, it is uncertain whether low dose ICSs are as effective as high dose in the treatment of inflammation and remodeling...
  6. ncbi request reprint Effects of methacholine on small airway function measured by forced oscillation technique and multiple breath nitrogen washout in normal subjects
    Gregory G King
    Woolcock Institute of Medical Research, Camperdown 2050, Australia
    Respir Physiol Neurobiol 148:165-77. 2005
    ..Scond is also related to lung size. We review the current state of knowledge of FOT and MBNW in obstructive lung diseases and discuss future research directions...
  7. doi request reprint Cutting edge technologies in respiratory research: lung function testing
    Gregory G King
    Woolcock Institute of Medical Research, The Northern Clinical School, Sydney Medical School, University of Sydney, New South Wales, Australia
    Respirology 16:883-90. 2011
    ..Optical coherence tomography, optical reflection, electrical impedance and vibration response imaging have arisen by development of novel devices. The recent use of these techniques is reviewed...
  8. doi request reprint Current and emerging imaging in relation to drug discovery in airways disease
    Gregory G King
    The Woolcock Institute of Medical Research, Sydney, NSW 2037, Australia
    Pulm Pharmacol Ther 24:497-504. 2011
    ....
  9. ncbi request reprint The effects of body weight on airway calibre
    G G King
    Woolcock Institute of Medical Research, Dept of Respiratory Medicine, Royal North Shore Hospital, Pacific Highway, St Leonards 2065, Australia
    Eur Respir J 25:896-901. 2005
    ..However, in males, airway narrowing is greater than that due to reduced lung volume alone. The mechanisms causing airway narrowing and sex differences in obesity are unknown...
  10. ncbi request reprint Effect of obesity on breathlessness and airway responsiveness to methacholine in non-asthmatic subjects
    C M Salome
    Woolcock Institute of Medical Research, Camperdown, New South Wales, Australia
    Int J Obes (Lond) 32:502-9. 2008
    ..Obesity reduces lung volumes, which can increase airway responsiveness, and increases resistive and elastic work of breathing, which can increase dyspnea...
  11. ncbi request reprint Airway re-narrowing following deep inspiration in asthmatic and nonasthmatic subjects
    C M Salome
    Woolcock Institute of Medical Research and Cooperative Research Centre for Asthma, University of Sydney, Australia
    Eur Respir J 22:62-8. 2003
    ....
  12. doi request reprint Small airways function declines after allogeneic haematopoietic stem cell transplantation
    S Lahzami
    The Woolcock Institute of Medical Research, University of Sydney, New South Wales, Australia
    Eur Respir J 38:1180-8. 2011
    ..In conclusion, peripheral airways ventilation heterogeneity worsens with time after HSCT. S(acin) may be more sensitive than spirometry in detecting BO at an early stage, which needs confirmation in a prospective study...
  13. ncbi request reprint Differences in airway closure between normal and asthmatic subjects measured with single-photon emission computed tomography and technegas
    G G King
    Institute of Respiratory Medicine and Department of Medicine, University of Sydney, Australia
    Am J Respir Crit Care Med 158:1900-6. 1998
    ..This pattern is lost in asthmatic subjects. This may be explained by an increased range of closing pressures and a patchy distribution of airway closure, probably secondary to allergic inflammation...
  14. ncbi request reprint Airway narrowing associated with inhibition of deep inspiration during methacholine inhalation in asthmatics
    G G King
    University of British Columbia, McDonald Research Laboratories and the i CAPTURE Center, St Paul s Hospital, Vancouver, British Columbia, Canada
    Am J Respir Crit Care Med 164:216-8. 2001
    ....
  15. ncbi request reprint A comparison of airway and serum matrix metalloproteinase-9 activity among normal subjects, asthmatic patients, and patients with asthmatic mucus hypersecretion
    Fanny W S Ko
    Woolcock Institute of Medical Research, University of Sydney, NSW, Australia
    Chest 127:1919-27. 2005
    ....
  16. ncbi request reprint Fexofenadine decreases sensitivity to and montelukast improves recovery from inhaled mannitol
    J D Brannan
    Department of Respiratory Medicine, PCP9, Royal Prince Alfred Hospital, Missenden Road, Camperdown, NSW 2006, Australia
    Am J Respir Crit Care Med 163:1420-5. 2001
    ..min) compared with placebo (513 +/- 182% change.min) (p < 0.001). We conclude that whereas histamine is important for the initial airway response, leukotrienes are important in sustaining the airway response to inhaled mannitol...
  17. doi request reprint Increased airway closure is a determinant of airway hyperresponsiveness
    D G Chapman
    Woolcock Institute of Medical Research, Box M77 Missenden Rd PO, Camperdown NSW 2050 Australia
    Eur Respir J 32:1563-9. 2008
    ..However, after adjusting for airway closure, obesity appears to protect against airway hyperresponsiveness...
  18. ncbi request reprint Modeling airway resistance dynamics after tidal and deep inspirations
    C William Thorpe
    Woolcock Institute of Medical Research, Camperdown, NSW 2050, Australia
    J Appl Physiol (1985) 97:1643-53. 2004
    ..66. This suggests that the same time-dependent factors determine renarrowing after both large and small breaths...
  19. doi request reprint Avoiding deep inspirations increases the maximal response to methacholine without altering sensitivity in non-asthmatics
    David G Chapman
    Woolcock Institute of Medical Research, PO Box M77 Missenden Road, Sydney, NSW 2050, Australia
    Respir Physiol Neurobiol 173:157-63. 2010
    ....
  20. doi request reprint Reference equations for respiratory system resistance and reactance in adults
    Nathan J Brown
    The Woolcock Institute of Medical Research, Glebe, NSW, Australia
    Respir Physiol Neurobiol 172:162-8. 2010
    ..To determine reference equations for respiratory system resistance and reactance in a large randomly selected sample from a general, predominantly Caucasian population...
  21. doi request reprint Physiology of obesity and effects on lung function
    Cheryl M Salome
    Woolcock Institute of Medical Research, P O Box M77, Missenden Rd NSW 2050, Australia
    J Appl Physiol (1985) 108:206-11. 2010
    ..Thus obesity has effects on lung function that can reduce respiratory well-being, even in the absence of specific respiratory disease, and may also exaggerate the effects of existing airway disease...
  22. ncbi request reprint Deep inspirations protect against airway closure in nonasthmatic subjects
    David G Chapman
    Woolcock Institute of Medical Research, Cooperative Research Centre for Asthma, University of Sydney, P O Box M77 Missenden Rd, Sydney, NSW 2050, Australia
    J Appl Physiol (1985) 107:564-9. 2009
    ..The protective effect of DI on FEV1 and FVC was abolished by expiration to residual volume. We speculate that the reduced airway closure is due to reduced baseline ventilation heterogeneity and/or reduced airway surface tension...
  23. pmc Ventilation heterogeneity is a major determinant of airway hyperresponsiveness in asthma, independent of airway inflammation
    Sue R Downie
    Woolcock Institute of Medical Research, Camperdown, NSW 2050, Australia
    Thorax 62:684-9. 2007
    ....
  24. ncbi request reprint Short-term variability of airway caliber-a marker of asthma?
    Chantale Diba
    The Woolcock Institute of Medical Research, Camperdown, New South Wales, Australia
    J Appl Physiol (1985) 103:296-304. 2007
    ..Our findings suggest that, using standard methods for forced oscillometry, impedance variability does not provide clinically useful information about the severity of asthma...
  25. ncbi request reprint Airway distensibility in adults with asthma and healthy adults, measured by forced oscillation technique
    Nathan J Brown
    Woolcock Institute of Medical Research, P O Box M77, Missenden Road, Camperdown, NSW, 2050 Australia
    Am J Respir Crit Care Med 176:129-37. 2007
    ..Reduced airway distensibility in subjects with asthma compared with control subjects may be related to differences in lung elastic recoil and bronchomotor tone...
  26. ncbi request reprint Airway dimensions measured from micro-computed tomography and high-resolution computed tomography
    J R Dame Carroll
    The Woolcock Institute of Medical Research, University of Sydney, Sydney 2006, Australia
    Eur Respir J 28:712-20. 2006
    ..The image dataset could be used to validate other developmental three-dimensional segmentation algorithms...
  27. ncbi request reprint Dysfunctional interaction of C/EBPalpha and the glucocorticoid receptor in asthmatic bronchial smooth-muscle cells
    Michael Roth
    Department of Pharmacology and the Woolcock Institute of Medical Research, University of Sydney, Sydney, Australia
    N Engl J Med 351:560-74. 2004
    ..We examined the signaling pathway controlling the inhibitory effect of glucocorticoids on cell proliferation and interleukin-6 synthesis in bronchial smooth-muscle cells of subjects with asthma and those without asthma...
  28. doi request reprint Objective analysis of whole lung and lobar ventilation/perfusion relationships in pulmonary embolism
    Benjamin Harris
    Department of Respiratory Medicine, Royal North Shore Hospital, St Leonards, Sydney, Australia
    Clin Physiol Funct Imaging 28:14-26. 2008
    ..We investigate this methodology using simulated data, and demonstrate its potential application in the clinical setting of PE...
  29. ncbi request reprint Objective analysis of tomographic ventilation-perfusion scintigraphy in pulmonary embolism
    Benjamin Harris
    Department of Respiratory Medicine, Royal North Shore Hospital, Pacific Highway, St Leonards 2065, Australia
    Am J Respir Crit Care Med 175:1173-80. 2007
    ..Objective analysis of single photon emission computed tomography (SPECT) three-dimensional scintigraphy may improve its diagnostic performance compared with subjective interpretation...
  30. ncbi request reprint Interaction between glucocorticoids and beta2 agonists on bronchial airway smooth muscle cells through synchronised cellular signalling
    Michael Roth
    Department of Pharmacology and the Woolcock Institute of Medical Research, University of Sydney, NSW 2006, Australia
    Lancet 360:1293-9. 2002
    ..Our aim was to elucidate how glucocorticoids and beta2 agonists affect the growth of human bronchial airway smooth muscle cells...
  31. ncbi request reprint Quantitative assessment of airway remodeling using high-resolution CT
    Yasutaka Nakano
    University of British Columbia, McDonald Research Laboratories iCAPTURE Center, St Paul s Hospital, Vancouver, BC, Canada
    Chest 122:271S-275S. 2002
    ..With additional advances in technology, it is likely that quantitative assessment of airway wall dimensions will ultimately provide a valuable tool for the study of airway disease...
  32. ncbi request reprint Diagnosis of subsegmental pulmonary emboli: a multi-center study using a porcine model
    Harvey O Coxson
    Department of Radiology, Vancouver General Hospital, Vancouver, BC, Canada
    J Thorac Imaging 20:24-31. 2005
    ....
  33. doi request reprint A clinical comparison between traditional planar V/Q images and planar images generated from SPECT V/Q scintigraphy
    Benjamin Harris
    Department of Respiratory Medicine, Royal North Shore Hospital, St Leonards, Australia
    Nucl Med Commun 29:323-30. 2008
    ..To compare interpretation of traditional planar ventilation-perfusion lung scan images with planar images reformatted from single photon emission computed tomography (SPECT) data using two different techniques...