A C Hurt

Summary

Affiliation: WHO Collaborating Centre for Reference and Research on Influenza
Country: Australia

Publications

  1. pmc Characteristics of a widespread community cluster of H275Y oseltamivir-resistant A(H1N1)pdm09 influenza in Australia
    A C Hurt
    WHO Collaborating Centre for Reference and Research on Influenza, North Melbourne, Victoria, Australia
    J Infect Dis 206:148-57. 2012
  2. pmc Mutations I117V and I117M and oseltamivir sensitivity of pandemic (H1N1) 2009 viruses
    Aeron C Hurt
    WHO Collaborating Centre for Reference and Research on Infl uenza, Victorian Infectious Diseases Reference Laboratory, 10 Wreckyn St, North Melbourne, 3051 Victoria, Australia
    Emerg Infect Dis 18:109-12. 2012
  3. ncbi request reprint Performance of six influenza rapid tests in detecting human influenza in clinical specimens
    Aeron C Hurt
    World Health Organisation Collaborating Centre for Reference and Research on Influenza, Parkville, Victoria, Australia
    J Clin Virol 39:132-5. 2007
  4. doi request reprint Emergence and spread of oseltamivir-resistant A(H1N1) influenza viruses in Oceania, South East Asia and South Africa
    Aeron C Hurt
    WHO Collaborating Centre for Reference and Research on Influenza, Victoria, Australia
    Antiviral Res 83:90-3. 2009
  5. pmc Zanamivir-resistant influenza viruses with a novel neuraminidase mutation
    Aeron C Hurt
    WHO Collaborating Centre for Reference and Research on Influenza, 10 Wreckyn St, North Melbourne, Victoria 3051, Australia
    J Virol 83:10366-73. 2009
  6. pmc In vitro generation of neuraminidase inhibitor resistance in A(H5N1) influenza viruses
    Aeron C Hurt
    WHO Collaborating Centre for Reference and Research on Influenza, North Melbourne, Victoria 3051, Australia
    Antimicrob Agents Chemother 53:4433-40. 2009
  7. doi request reprint Oseltamivir resistance and the H274Y neuraminidase mutation in seasonal, pandemic and highly pathogenic influenza viruses
    Aeron C Hurt
    WHO Collaborating Centre for Reference and Research on Influenza, Melbourne, Victoria, Australia
    Drugs 69:2523-31. 2009
  8. doi request reprint Assessing the development of oseltamivir and zanamivir resistance in A(H5N1) influenza viruses using a ferret model
    Aeron C Hurt
    WHO Collaborating Centre for Reference and Research on Influenza, North Melbourne, Victoria 3051, Australia
    Antiviral Res 87:361-6. 2010
  9. pmc Assessing the viral fitness of oseltamivir-resistant influenza viruses in ferrets, using a competitive-mixtures model
    Aeron C Hurt
    WHO Collaborating Centre for Reference and Research on Influenza, 10 Wreckyn St, North Melbourne, Victoria 3051, Australia
    J Virol 84:9427-38. 2010
  10. ncbi request reprint Community Transmission of Oseltamivir-Resistant A(H1N1)pdm09 Influenza
    Aeron C Hurt
    World Health Organization WHO Collaborating Centre for Reference and Research on Influenza, North Melbourne, Vic, Australia
    N Engl J Med 365:2541-2. 2011

Collaborators

Detail Information

Publications31

  1. pmc Characteristics of a widespread community cluster of H275Y oseltamivir-resistant A(H1N1)pdm09 influenza in Australia
    A C Hurt
    WHO Collaborating Centre for Reference and Research on Influenza, North Melbourne, Victoria, Australia
    J Infect Dis 206:148-57. 2012
    ..Oseltamivir resistance in A(H1N1)pdm09 influenza is rare, particularly in untreated community cases. Sustained community transmission has not previously been reported...
  2. pmc Mutations I117V and I117M and oseltamivir sensitivity of pandemic (H1N1) 2009 viruses
    Aeron C Hurt
    WHO Collaborating Centre for Reference and Research on Infl uenza, Victorian Infectious Diseases Reference Laboratory, 10 Wreckyn St, North Melbourne, 3051 Victoria, Australia
    Emerg Infect Dis 18:109-12. 2012
    ..Contrary to recent reports, the I117M mutation does not alter oseltamivir sensitivity...
  3. ncbi request reprint Performance of six influenza rapid tests in detecting human influenza in clinical specimens
    Aeron C Hurt
    World Health Organisation Collaborating Centre for Reference and Research on Influenza, Parkville, Victoria, Australia
    J Clin Virol 39:132-5. 2007
    ..The rapid tests have also been used to detect outbreaks in institutions and may play a role in pandemic influenza control...
  4. doi request reprint Emergence and spread of oseltamivir-resistant A(H1N1) influenza viruses in Oceania, South East Asia and South Africa
    Aeron C Hurt
    WHO Collaborating Centre for Reference and Research on Influenza, Victoria, Australia
    Antiviral Res 83:90-3. 2009
    ..The mutation had no impact on zanamivir susceptibility. Ongoing surveillance is essential to monitor how these strains may spread or persist in the future and to evaluate the effectiveness of treatments against them...
  5. pmc Zanamivir-resistant influenza viruses with a novel neuraminidase mutation
    Aeron C Hurt
    WHO Collaborating Centre for Reference and Research on Influenza, 10 Wreckyn St, North Melbourne, Victoria 3051, Australia
    J Virol 83:10366-73. 2009
    ..Compared to susceptible influenza A (H1N1) viruses, the Q136K mutant strains displayed greater viral fitness than the wild-type virus in MDCK cells but equivalent infectivity and transmissibility in a ferret model...
  6. pmc In vitro generation of neuraminidase inhibitor resistance in A(H5N1) influenza viruses
    Aeron C Hurt
    WHO Collaborating Centre for Reference and Research on Influenza, North Melbourne, Victoria 3051, Australia
    Antimicrob Agents Chemother 53:4433-40. 2009
    ..This study identified the mutations that can arise in A(H5N1) under either oseltamivir or zanamivir selective pressure and the potential for dual neuraminidase mutations to result in dramatically reduced drug susceptibility...
  7. doi request reprint Oseltamivir resistance and the H274Y neuraminidase mutation in seasonal, pandemic and highly pathogenic influenza viruses
    Aeron C Hurt
    WHO Collaborating Centre for Reference and Research on Influenza, Melbourne, Victoria, Australia
    Drugs 69:2523-31. 2009
    ....
  8. doi request reprint Assessing the development of oseltamivir and zanamivir resistance in A(H5N1) influenza viruses using a ferret model
    Aeron C Hurt
    WHO Collaborating Centre for Reference and Research on Influenza, North Melbourne, Victoria 3051, Australia
    Antiviral Res 87:361-6. 2010
    ..Further animal studies and human clinical trials are necessary to optimize neuraminidase inhibitor dosing strategies for the treatment of influenza A(H5N1) infections...
  9. pmc Assessing the viral fitness of oseltamivir-resistant influenza viruses in ferrets, using a competitive-mixtures model
    Aeron C Hurt
    WHO Collaborating Centre for Reference and Research on Influenza, 10 Wreckyn St, North Melbourne, Victoria 3051, Australia
    J Virol 84:9427-38. 2010
    ..Our statistical inferences are essential for the development of the next generation of mathematical models of the emergence and spread of oseltamivir-resistant influenza in human populations...
  10. ncbi request reprint Community Transmission of Oseltamivir-Resistant A(H1N1)pdm09 Influenza
    Aeron C Hurt
    World Health Organization WHO Collaborating Centre for Reference and Research on Influenza, North Melbourne, Vic, Australia
    N Engl J Med 365:2541-2. 2011
    ..Community circulation of an oseltamivir-resistant strain of the novel pandemic influenza A (H1N1) virus has been identified in Australia...
  11. ncbi request reprint Resistance to anti-influenza drugs: adamantanes and neuraminidase inhibitors
    Aeron C Hurt
    World Health Organization Collaborating Centre for Reference and Research on Influenza, Monash University, School of Applied Sciences, 45 Poplar Road, Parkville, Victoria 3052, Australia
    Expert Rev Anti Infect Ther 4:795-805. 2006
    ..In this review, resistance to the adamantanes and neuraminidase inhibitors will be discussed in relation to both epidemic and pandemic influenza viruses...
  12. ncbi request reprint Isolation of avian influenza viruses from two different transhemispheric migratory shorebird species in Australia
    A C Hurt
    World Health Organisation Collaborating Centre for Reference and Research on Influenza, Parkville, Australia
    Arch Virol 151:2301-9. 2006
    ..No H5N1 viruses were detected. All isolated viruses were non-pathogenic in domestic chickens. These results further demonstrate the potential for migratory shorebirds to carry and potentially spread influenza viruses...
  13. ncbi request reprint Susceptibility of highly pathogenic A(H5N1) avian influenza viruses to the neuraminidase inhibitors and adamantanes
    A C Hurt
    World Health Organisation Collaborating Centre for Reference and Research on Influenza, 45 Poplar Road, Parkville, Victoria 3052, Australia
    Antiviral Res 73:228-31. 2007
    ..These results support the use of neuraminidase inhibitors as the most appropriate class of antiviral drug to prevent or treat human A(H5N1) virus infections...
  14. pmc Neuraminidase inhibitor-resistant and -sensitive influenza B viruses isolated from an untreated human patient
    Aeron C Hurt
    WHO Collaborating Centre for Reference and Research on Influenza, 45 Poplar Rd, Parkville, Victoria 3052, Australia
    Antimicrob Agents Chemother 50:1872-4. 2006
    ..Here, we describe the analysis of a mixed viral population that contained a novel D197E amino acid substitution that was responsible for this reduction...
  15. doi request reprint Adamantane resistance in influenza A(H1) viruses increased in 2007 in South East Asia but decreased in Australia and some other countries
    I G Barr
    WHO Collaborating Centre for Reference and Research on Influenza, Parkville, Melbourne, Victoria, Australia
    Antiviral Res 80:200-5. 2008
    ....
  16. ncbi request reprint The emergence of adamantane resistance in influenza A(H1) viruses in Australia and regionally in 2006
    I G Barr
    WHO Collaborating Centre for Reference and Research on Influenza, 45 Poplar Road, Parkville, Melbourne 3052, Australia
    Antiviral Res 75:173-6. 2007
    ..8% of the 2006 viruses had a resistant genotype. By comparison, 58.6% of influenza A(H3) viruses isolated in 2006 that were tested at the Centre, had a resistant genotype...
  17. ncbi request reprint Increased adamantane resistance in influenza A(H3) viruses in Australia and neighbouring countries in 2005
    I G Barr
    WHO Collaborating Centre for Reference and Research on Influenza, 45 Poplar Road, Parkville, Melbourne 3052, Australia
    Antiviral Res 73:112-7. 2007
    ..In this study we analysed recent human influenza A strains isolated in Australia and regionally for evidence of resistance to adamantanes and found evidence of significant resistant emerging during 2005...
  18. ncbi request reprint Susceptibility of human influenza viruses from Australasia and South East Asia to the neuraminidase inhibitors zanamivir and oseltamivir
    Aeron C Hurt
    WHO Collaborating Centre for Reference and Research on Influenza, 45 Poplar Road, Parkville, VIC 3052, Australia
    Antiviral Res 62:37-45. 2004
    ....
  19. ncbi request reprint Surveillance for neuraminidase inhibitor resistance in human influenza viruses from Australia
    Aeron C Hurt
    WHO Collaborating Centre for Reference and Research on Influenza, Melbourne, Australia
    Commun Dis Intell Q Rep 27:542-7. 2003
    ....
  20. ncbi request reprint An influenza A(H3) reassortant was epidemic in Australia and New Zealand in 2003
    I G Barr
    WHO Collaborating Centre for Reference and Research on Influenza, Parkville, Victoria, Australia
    J Med Virol 76:391-7. 2005
    ..This was suggestive of the re-introduction of influenza A(H3) from other countries, however, there was still low level circulation of the reassortant virus in 2004 with isolates detected in Australia and Singapore...
  21. ncbi request reprint Identification of a human influenza type B strain with reduced sensitivity to neuraminidase inhibitor drugs
    Aeron C Hurt
    WHO Collaborating Centre for Reference and Research on Influenza, 45 Poplar Road, Melbourne, VIC 3052, Australia
    Virus Res 103:205-11. 2004
    ..Further investigations are in progress to identify the basis for this reduced sensitivity...
  22. ncbi request reprint A novel means of identifying the neuraminidase type of currently circulating human A(H1) influenza viruses
    Aeron C Hurt
    WHO Collaborating Centre for Reference and Research on Influenza, 45 Poplar Rd, Parkville, Melbourne, VIC 3052, Australia
    Virus Res 103:79-83. 2004
    ..5% for the identification of neuraminidase type N1 or N2. This assay enables a large number of influenza A viruses to be screened at low cost to determine relative levels of A(H1N2) or A(H1N1) viruses circulating in the population...
  23. ncbi request reprint In vitro generation and characterisation of an influenza B variant with reduced sensitivity to neuraminidase inhibitors
    Ai Lee Cheam
    World Health Organisation Collaborating Centre for Reference and Research on Influenza, 45 Poplar Road, Parkville, Victoria 3052, Australia
    Antiviral Res 63:177-81. 2004
    ..Tissue culture assays demonstrated that the HA mutation caused a seven-fold reduction in sensitivity to oseltamivir carboxylate, and a 90-fold reduction in sensitivity to zanamivir...
  24. ncbi request reprint Neuraminidase inhibitor drug susceptibility differs between influenza N1 and N2 neuraminidase following mutagenesis of two conserved residues
    Hui Ting Ho
    World Health Organisation Collaborating Centre for Reference and Research on Influenza, Parkville, Vic, Australia
    Antiviral Res 76:263-6. 2007
    ..This study confirmed the essential role of NA active site residues in viral fitness, and identified clear differences in the role of residues E227 and E276 in NA inhibitor resistance with N1 and N2 neuraminidases...
  25. ncbi request reprint Genetic analysis of two influenza A (H1) swine viruses isolated from humans in Thailand and the Philippines
    N Komadina
    WHO Collaborating Centre for Reference and Research on Influenza, 45 Poplar Rd, Parkville, VIC 3052, Australia
    Virus Genes 35:161-5. 2007
    ....
  26. ncbi request reprint Circulation and antigenic drift in human influenza B viruses in SE Asia and Oceania since 2000
    Ian G Barr
    WHO Collaborating Centre for Reference and Research on Influenza, Parkville, Victoria
    Commun Dis Intell Q Rep 30:350-7. 2006
    ..This is an important consideration for influenza vaccine formulation decisions, as only one influenza B component is traditionally included in the annual trivalent influenza vaccine...
  27. ncbi request reprint A comparison of a rapid test for influenza with laboratory-based diagnosis in a paediatric population
    Robert Alexander
    Royal Children s Hospital, Parkville, Victoria
    Commun Dis Intell 29:272-6. 2005
    ....
  28. ncbi request reprint Influenza viruses with reduced sensitivity to the neuraminidase inhibitor drugs in untreated young children
    Aeron C Hurt
    WHO Collaborating Centre for Reference and Research on Influenza, Parkville, Victoria
    Commun Dis Intell Q Rep 32:57-62. 2008
    ..Given these results it may be important to enhance neuraminidase inhibitor susceptibility testing of viruses from patients in the less than two years cohort...
  29. doi request reprint Performance of influenza rapid point-of-care tests in the detection of swine lineage A(H1N1) influenza viruses
    Aeron C Hurt
    WHO Collaborating Centre for Reference and Research on Influenza, 10 Wreckyn St, North Melbourne, Victoria, Australia
    Influenza Other Respi Viruses 3:171-6. 2009
    ..In April 2009, an A(H1N1) influenza virus of swine lineage was detected in humans in the USA, and in just over a month has infected over 10,000 people in more than 40 countries...
  30. pmc Injectable peramivir mitigates disease and promotes survival in ferrets and mice infected with the highly virulent influenza virus, A/Vietnam/1203/04 (H5N1)
    Nadezhda E Yun
    Center for Biodefense and Emerging Infectious Diseases, Department of Pathology, University of Texas Medical Branch, Galveston, TX, USA
    Virology 374:198-209. 2008
    ..A single intramuscular peramivir injection protected mice against severe disease outcomes following infection with highly pathogenic avian influenza and multi-dose treatment was efficacious in ferrets...
  31. doi request reprint The global circulation of seasonal influenza A (H3N2) viruses
    Colin A Russell
    Department of Zoology, University of Cambridge, Cambridge, UK
    Science 320:340-6. 2008
    ....