I G Barr

Summary

Affiliation: WHO Collaborating Centre for Reference and Research on Influenza
Country: Australia

Publications

  1. ncbi request reprint Susceptibility of human influenza viruses from Australasia and South East Asia to the neuraminidase inhibitors zanamivir and oseltamivir
    Aeron C Hurt
    WHO Collaborating Centre for Reference and Research on Influenza, 45 Poplar Road, Parkville, VIC 3052, Australia
    Antiviral Res 62:37-45. 2004
  2. pmc Teacher led school-based surveillance can allow accurate tracking of emerging infectious diseases - evidence from serial cross-sectional surveys of febrile respiratory illness during the H1N1 2009 influenza pandemic in Singapore
    Shu E Soh
    National University of Singapore, 21 Lower Kent Ridge Road, Singapore 119077, Singapore
    BMC Infect Dis 12:336. 2012
  3. pmc Specific detection of H5N1 avian influenza A virus in field specimens by a one-step RT-PCR assay
    Lisa Fp Ng
    Genome Institute of Singapore, 60 Biopolis Street, Genome, 02 01, 138672, Singapore
    BMC Infect Dis 6:40. 2006
  4. pmc Seroconversion and asymptomatic infections during oseltamivir prophylaxis against Influenza A H1N1 2009
    Vernon J Lee
    Biodefence Centre, Ministry of Defence, Transit Road, Singapore 778910, Singapore
    BMC Infect Dis 10:164. 2010
  5. ncbi request reprint Circulation and antigenic drift in human influenza B viruses in SE Asia and Oceania since 2000
    Ian G Barr
    WHO Collaborating Centre for Reference and Research on Influenza, Parkville, Victoria
    Commun Dis Intell Q Rep 30:350-7. 2006
  6. ncbi request reprint The emergence of adamantane resistance in influenza A(H1) viruses in Australia and regionally in 2006
    I G Barr
    WHO Collaborating Centre for Reference and Research on Influenza, 45 Poplar Road, Parkville, Melbourne 3052, Australia
    Antiviral Res 75:173-6. 2007
  7. doi request reprint Adamantane resistance in influenza A(H1) viruses increased in 2007 in South East Asia but decreased in Australia and some other countries
    I G Barr
    WHO Collaborating Centre for Reference and Research on Influenza, Parkville, Melbourne, Victoria, Australia
    Antiviral Res 80:200-5. 2008
  8. ncbi request reprint An influenza A(H3) reassortant was epidemic in Australia and New Zealand in 2003
    I G Barr
    WHO Collaborating Centre for Reference and Research on Influenza, Parkville, Victoria, Australia
    J Med Virol 76:391-7. 2005
  9. ncbi request reprint The rapid identification of human influenza neuraminidase N1 and N2 subtypes by ELISA
    I G Barr
    WHO Collaborating Centre for Reference and Research on Influenza, 45 Poplar Road, Parkville, Victoria 3052, Australia
    Vaccine 24:6675-8. 2006
  10. doi request reprint Epidemiological, antigenic and genetic characteristics of seasonal influenza A(H1N1), A(H3N2) and B influenza viruses: basis for the WHO recommendation on the composition of influenza vaccines for use in the 2009-2010 Northern Hemisphere season
    Ian G Barr
    WHO Collaborating Centre for Reference and Research on Influenza, VIDRL, Melbourne, Australia
    Vaccine 28:1156-67. 2010

Collaborators

Detail Information

Publications44

  1. ncbi request reprint Susceptibility of human influenza viruses from Australasia and South East Asia to the neuraminidase inhibitors zanamivir and oseltamivir
    Aeron C Hurt
    WHO Collaborating Centre for Reference and Research on Influenza, 45 Poplar Road, Parkville, VIC 3052, Australia
    Antiviral Res 62:37-45. 2004
    ....
  2. pmc Teacher led school-based surveillance can allow accurate tracking of emerging infectious diseases - evidence from serial cross-sectional surveys of febrile respiratory illness during the H1N1 2009 influenza pandemic in Singapore
    Shu E Soh
    National University of Singapore, 21 Lower Kent Ridge Road, Singapore 119077, Singapore
    BMC Infect Dis 12:336. 2012
    ..We compared several school-based influenza monitoring systems with clinic-based influenza-like illness (ILI) surveillance, and assessed the variation in illness rates between and within schools...
  3. pmc Specific detection of H5N1 avian influenza A virus in field specimens by a one-step RT-PCR assay
    Lisa Fp Ng
    Genome Institute of Singapore, 60 Biopolis Street, Genome, 02 01, 138672, Singapore
    BMC Infect Dis 6:40. 2006
    ..We report here the development of a PCR-based assay that is highly specific for the H5N1 avian influenza A virus...
  4. pmc Seroconversion and asymptomatic infections during oseltamivir prophylaxis against Influenza A H1N1 2009
    Vernon J Lee
    Biodefence Centre, Ministry of Defence, Transit Road, Singapore 778910, Singapore
    BMC Infect Dis 10:164. 2010
    ..Anti-viral prophylaxis is used to prevent the transmission of influenza. We studied serological confirmation of 2009 Influenza A (H1N1) infections during oseltamivir prophylaxis and after cessation of prophylaxis...
  5. ncbi request reprint Circulation and antigenic drift in human influenza B viruses in SE Asia and Oceania since 2000
    Ian G Barr
    WHO Collaborating Centre for Reference and Research on Influenza, Parkville, Victoria
    Commun Dis Intell Q Rep 30:350-7. 2006
    ..This is an important consideration for influenza vaccine formulation decisions, as only one influenza B component is traditionally included in the annual trivalent influenza vaccine...
  6. ncbi request reprint The emergence of adamantane resistance in influenza A(H1) viruses in Australia and regionally in 2006
    I G Barr
    WHO Collaborating Centre for Reference and Research on Influenza, 45 Poplar Road, Parkville, Melbourne 3052, Australia
    Antiviral Res 75:173-6. 2007
    ..8% of the 2006 viruses had a resistant genotype. By comparison, 58.6% of influenza A(H3) viruses isolated in 2006 that were tested at the Centre, had a resistant genotype...
  7. doi request reprint Adamantane resistance in influenza A(H1) viruses increased in 2007 in South East Asia but decreased in Australia and some other countries
    I G Barr
    WHO Collaborating Centre for Reference and Research on Influenza, Parkville, Melbourne, Victoria, Australia
    Antiviral Res 80:200-5. 2008
    ....
  8. ncbi request reprint An influenza A(H3) reassortant was epidemic in Australia and New Zealand in 2003
    I G Barr
    WHO Collaborating Centre for Reference and Research on Influenza, Parkville, Victoria, Australia
    J Med Virol 76:391-7. 2005
    ..This was suggestive of the re-introduction of influenza A(H3) from other countries, however, there was still low level circulation of the reassortant virus in 2004 with isolates detected in Australia and Singapore...
  9. ncbi request reprint The rapid identification of human influenza neuraminidase N1 and N2 subtypes by ELISA
    I G Barr
    WHO Collaborating Centre for Reference and Research on Influenza, 45 Poplar Road, Parkville, Victoria 3052, Australia
    Vaccine 24:6675-8. 2006
    ..This method is simple, rapid and can be used to screen large numbers of currently circulating human influenza A viruses for their neurraminidase subtype and is a good alternative to RT-PCR...
  10. doi request reprint Epidemiological, antigenic and genetic characteristics of seasonal influenza A(H1N1), A(H3N2) and B influenza viruses: basis for the WHO recommendation on the composition of influenza vaccines for use in the 2009-2010 Northern Hemisphere season
    Ian G Barr
    WHO Collaborating Centre for Reference and Research on Influenza, VIDRL, Melbourne, Australia
    Vaccine 28:1156-67. 2010
    ..This article gives a summary of the data and background to the recommendations for the 2009-2010 Northern Hemisphere influenza vaccine formulation...
  11. ncbi request reprint Increased adamantane resistance in influenza A(H3) viruses in Australia and neighbouring countries in 2005
    I G Barr
    WHO Collaborating Centre for Reference and Research on Influenza, 45 Poplar Road, Parkville, Melbourne 3052, Australia
    Antiviral Res 73:112-7. 2007
    ..In this study we analysed recent human influenza A strains isolated in Australia and regionally for evidence of resistance to adamantanes and found evidence of significant resistant emerging during 2005...
  12. ncbi request reprint Reassortants in recent human influenza A and B isolates from South East Asia and Oceania
    I G Barr
    WHO Collaborating Centre for Reference and Research on Influenza, 45 Poplar Road, Parkville 3052, Vic, Australia
    Virus Res 98:35-44. 2003
    ..In contrast the reassortant B viruses, which first emerged in this region in early 2002, rapidly became the predominant strains isolated from patients with influenza B in South East Asia and Oceania...
  13. ncbi request reprint Surveillance for neuraminidase inhibitor resistance in human influenza viruses from Australia
    Aeron C Hurt
    WHO Collaborating Centre for Reference and Research on Influenza, Melbourne, Australia
    Commun Dis Intell Q Rep 27:542-7. 2003
    ....
  14. ncbi request reprint Identification of a human influenza type B strain with reduced sensitivity to neuraminidase inhibitor drugs
    Aeron C Hurt
    WHO Collaborating Centre for Reference and Research on Influenza, 45 Poplar Road, Melbourne, VIC 3052, Australia
    Virus Res 103:205-11. 2004
    ..Further investigations are in progress to identify the basis for this reduced sensitivity...
  15. ncbi request reprint Susceptibility of highly pathogenic A(H5N1) avian influenza viruses to the neuraminidase inhibitors and adamantanes
    A C Hurt
    World Health Organisation Collaborating Centre for Reference and Research on Influenza, 45 Poplar Road, Parkville, Victoria 3052, Australia
    Antiviral Res 73:228-31. 2007
    ..These results support the use of neuraminidase inhibitors as the most appropriate class of antiviral drug to prevent or treat human A(H5N1) virus infections...
  16. ncbi request reprint Isolation of avian influenza viruses from two different transhemispheric migratory shorebird species in Australia
    A C Hurt
    World Health Organisation Collaborating Centre for Reference and Research on Influenza, Parkville, Australia
    Arch Virol 151:2301-9. 2006
    ..No H5N1 viruses were detected. All isolated viruses were non-pathogenic in domestic chickens. These results further demonstrate the potential for migratory shorebirds to carry and potentially spread influenza viruses...
  17. ncbi request reprint In vitro generation and characterisation of an influenza B variant with reduced sensitivity to neuraminidase inhibitors
    Ai Lee Cheam
    World Health Organisation Collaborating Centre for Reference and Research on Influenza, 45 Poplar Road, Parkville, Victoria 3052, Australia
    Antiviral Res 63:177-81. 2004
    ..Tissue culture assays demonstrated that the HA mutation caused a seven-fold reduction in sensitivity to oseltamivir carboxylate, and a 90-fold reduction in sensitivity to zanamivir...
  18. ncbi request reprint A novel means of identifying the neuraminidase type of currently circulating human A(H1) influenza viruses
    Aeron C Hurt
    WHO Collaborating Centre for Reference and Research on Influenza, 45 Poplar Rd, Parkville, Melbourne, VIC 3052, Australia
    Virus Res 103:79-83. 2004
    ..5% for the identification of neuraminidase type N1 or N2. This assay enables a large number of influenza A viruses to be screened at low cost to determine relative levels of A(H1N2) or A(H1N1) viruses circulating in the population...
  19. pmc Characteristics of a widespread community cluster of H275Y oseltamivir-resistant A(H1N1)pdm09 influenza in Australia
    A C Hurt
    WHO Collaborating Centre for Reference and Research on Influenza, North Melbourne, Victoria, Australia
    J Infect Dis 206:148-57. 2012
    ..Oseltamivir resistance in A(H1N1)pdm09 influenza is rare, particularly in untreated community cases. Sustained community transmission has not previously been reported...
  20. ncbi request reprint Genetic analysis of two influenza A (H1) swine viruses isolated from humans in Thailand and the Philippines
    N Komadina
    WHO Collaborating Centre for Reference and Research on Influenza, 45 Poplar Rd, Parkville, VIC 3052, Australia
    Virus Genes 35:161-5. 2007
    ....
  21. ncbi request reprint A comparison of a rapid test for influenza with laboratory-based diagnosis in a paediatric population
    Robert Alexander
    Royal Children s Hospital, Parkville, Victoria
    Commun Dis Intell 29:272-6. 2005
    ....
  22. pmc In vitro generation of neuraminidase inhibitor resistance in A(H5N1) influenza viruses
    Aeron C Hurt
    WHO Collaborating Centre for Reference and Research on Influenza, North Melbourne, Victoria 3051, Australia
    Antimicrob Agents Chemother 53:4433-40. 2009
    ..This study identified the mutations that can arise in A(H5N1) under either oseltamivir or zanamivir selective pressure and the potential for dual neuraminidase mutations to result in dramatically reduced drug susceptibility...
  23. pmc MDCK-SIAT1 cells show improved isolation rates for recent human influenza viruses compared to conventional MDCK cells
    Ding Yuan Oh
    WHO Collaborating Centre for Reference and Research on Influenza, 45 Poplar Road, Parkville, Melbourne, Australia
    J Clin Microbiol 46:2189-94. 2008
    ....
  24. doi request reprint Oseltamivir resistance and the H274Y neuraminidase mutation in seasonal, pandemic and highly pathogenic influenza viruses
    Aeron C Hurt
    WHO Collaborating Centre for Reference and Research on Influenza, Melbourne, Victoria, Australia
    Drugs 69:2523-31. 2009
    ....
  25. pmc Zanamivir-resistant influenza viruses with a novel neuraminidase mutation
    Aeron C Hurt
    WHO Collaborating Centre for Reference and Research on Influenza, 10 Wreckyn St, North Melbourne, Victoria 3051, Australia
    J Virol 83:10366-73. 2009
    ..Compared to susceptible influenza A (H1N1) viruses, the Q136K mutant strains displayed greater viral fitness than the wild-type virus in MDCK cells but equivalent infectivity and transmissibility in a ferret model...
  26. ncbi request reprint Performance of six influenza rapid tests in detecting human influenza in clinical specimens
    Aeron C Hurt
    World Health Organisation Collaborating Centre for Reference and Research on Influenza, Parkville, Victoria, Australia
    J Clin Virol 39:132-5. 2007
    ..The rapid tests have also been used to detect outbreaks in institutions and may play a role in pandemic influenza control...
  27. doi request reprint Assessing the development of oseltamivir and zanamivir resistance in A(H5N1) influenza viruses using a ferret model
    Aeron C Hurt
    WHO Collaborating Centre for Reference and Research on Influenza, North Melbourne, Victoria 3051, Australia
    Antiviral Res 87:361-6. 2010
    ..Further animal studies and human clinical trials are necessary to optimize neuraminidase inhibitor dosing strategies for the treatment of influenza A(H5N1) infections...
  28. pmc Neuraminidase inhibitor-resistant and -sensitive influenza B viruses isolated from an untreated human patient
    Aeron C Hurt
    WHO Collaborating Centre for Reference and Research on Influenza, 45 Poplar Rd, Parkville, Victoria 3052, Australia
    Antimicrob Agents Chemother 50:1872-4. 2006
    ..Here, we describe the analysis of a mixed viral population that contained a novel D197E amino acid substitution that was responsible for this reduction...
  29. pmc Assessing the viral fitness of oseltamivir-resistant influenza viruses in ferrets, using a competitive-mixtures model
    Aeron C Hurt
    WHO Collaborating Centre for Reference and Research on Influenza, 10 Wreckyn St, North Melbourne, Victoria 3051, Australia
    J Virol 84:9427-38. 2010
    ..Our statistical inferences are essential for the development of the next generation of mathematical models of the emergence and spread of oseltamivir-resistant influenza in human populations...
  30. doi request reprint Multiple infections with seasonal influenza A virus induce cross-protective immunity against A(H1N1) pandemic influenza virus in a ferret model
    Karen L Laurie
    World Health Organization Collaborating Centre for Reference and Research on Influenza, Victorian Infectious Diseases Reference Laboratory, North Melbourne, Australia
    J Infect Dis 202:1011-20. 2010
    ..The contribution of preexisting immunity to seasonal influenza to protection against A(H1N1)pdm infection was analyzed in a ferret model...
  31. doi request reprint Emergence and spread of oseltamivir-resistant A(H1N1) influenza viruses in Oceania, South East Asia and South Africa
    Aeron C Hurt
    WHO Collaborating Centre for Reference and Research on Influenza, Victoria, Australia
    Antiviral Res 83:90-3. 2009
    ..The mutation had no impact on zanamivir susceptibility. Ongoing surveillance is essential to monitor how these strains may spread or persist in the future and to evaluate the effectiveness of treatments against them...
  32. ncbi request reprint Identification of genetic diversity by cultivating influenza A(H3N2) virus in vitro in the presence of post-infection sera from small children
    L R Haaheim
    WHO Collaborating Centre for Reference and Research on Influenza, 45 Poplar Road, Parkville, VIC 3052, Australia
    Vaccine 24:6708-11. 2006
    ..On a community level, it is possible that antigenic changes could be accumulated in a step-wise manner when epidemic virus is transmitted from one small child to the next, each with a restricted and possibly variant antibody repertoire...
  33. ncbi request reprint Influenza viruses with reduced sensitivity to the neuraminidase inhibitor drugs in untreated young children
    Aeron C Hurt
    WHO Collaborating Centre for Reference and Research on Influenza, Parkville, Victoria
    Commun Dis Intell Q Rep 32:57-62. 2008
    ..Given these results it may be important to enhance neuraminidase inhibitor susceptibility testing of viruses from patients in the less than two years cohort...
  34. ncbi request reprint Overexpression, purification, and refolding of a Porphyromonas gingivalis cysteine protease from Escherichia coli
    M B Margetts
    Research and Development Division, CSL Ltd, 45 Poplar Road, Parkville, Victoria, 3052, Australia
    Protein Expr Purif 18:262-8. 2000
    ..gingivalis strain W50, indicating that the recombinant protein contained some of the antigenic determinants of the native protease...
  35. doi request reprint Performance of influenza rapid point-of-care tests in the detection of swine lineage A(H1N1) influenza viruses
    Aeron C Hurt
    WHO Collaborating Centre for Reference and Research on Influenza, 10 Wreckyn St, North Melbourne, Victoria, Australia
    Influenza Other Respir Viruses 3:171-6. 2009
    ..In April 2009, an A(H1N1) influenza virus of swine lineage was detected in humans in the USA, and in just over a month has infected over 10,000 people in more than 40 countries...
  36. ncbi request reprint High proportion of influenza B characterises the 2008 influenza season in Victoria
    Kristina A Grant
    Victorian Infectious Diseases Reference Laboratory, Melbourne, Victoria
    Commun Dis Intell Q Rep 33:328-36. 2009
    ..Overall 56% of notifications of laboratory confirmed influenza to DHS and 56% of influenza positive swabs from sentinel surveillance were influenza type B...
  37. pmc Injectable peramivir mitigates disease and promotes survival in ferrets and mice infected with the highly virulent influenza virus, A/Vietnam/1203/04 (H5N1)
    Nadezhda E Yun
    Center for Biodefense and Emerging Infectious Diseases, Department of Pathology, University of Texas Medical Branch, Galveston, TX, USA
    Virology 374:198-209. 2008
    ..A single intramuscular peramivir injection protected mice against severe disease outcomes following infection with highly pathogenic avian influenza and multi-dose treatment was efficacious in ferrets...
  38. doi request reprint The global circulation of seasonal influenza A (H3N2) viruses
    Colin A Russell
    Department of Zoology, University of Cambridge, Cambridge, UK
    Science 320:340-6. 2008
    ....
  39. ncbi request reprint Annual report of the National Influenza Surveillance Scheme, 2006
    Kathleen O'Brien
    Office of Health Protection, Australian Government Department of Health and Ageing, Canberra, Australian Capital Territory
    Commun Dis Intell Q Rep 31:167-79. 2007
    ..The B viruses isolated were predominately of the B/Victoria-lineage and similar to the reference/vaccine strain B/Malaysia/2506/2004...
  40. ncbi request reprint Annual report of the National Influenza Surveillance Scheme, 2005
    Simon M Firestone
    Surveillance Policy and Systems Section, Office of Health Protection, Australian Government Department of Health and Ageing, Canberra, Australian Capital Territory
    Commun Dis Intell Q Rep 30:189-200. 2006
    ....
  41. ncbi request reprint Annual report of the National Influenza Surveillance Scheme, 2007
    Rhonda Owen
    Office of Health Protection, Australian Government Department of Health and Ageing, Canberra, Australian Capital Territory
    Commun Dis Intell Q Rep 32:208-26. 2008
    ..It enabled the current state of our surveillance systems to be assessed and opportunities for improvement to be identified...
  42. ncbi request reprint Laboratory-based influenza surveillance in New Caledonia, 1999-2003
    Alain Berlioz-Arthaud
    Institut Pasteur de Nouvelle Caledonie, B P 61, 98845 Nouméa cedex, New Caledonia
    Trans R Soc Trop Med Hyg 99:290-300. 2005
    ..This study emphasises the need for regular influenza surveillance, even when performed on a limited scale. Importantly the optimal time for local vaccination was found to be in December or January each year...
  43. ncbi request reprint Vaccination with recombinant adhesins from the RgpA-Kgp proteinase-adhesin complex protects against Porphyromonas gingivalis infection
    Leanne T Frazer
    Cooperative Research Centre for Oral Health Science, School of Dental Science, The University of Melbourne, 720 Swanston Street, Victoria 3010, Australia
    Vaccine 24:6542-54. 2006
    ..gingivalis serotypes and clinical isolates tested. The recombinant A1 adhesin therefore has potential in the development of a P. gingivalis vaccine...
  44. ncbi request reprint Laboratory diagnosis of human seasonal and pandemic influenza virus infection
    Dominic E Dwyer
    Centre for Infectious Diseases and Microbiology Laboratory Services, Institute of Clinical Pathology and Medical Research, Westmead Hospital, Sydney, NSW, Australia
    Med J Aust 185:S48-53. 2006
    ..Monitoring for antiviral resistance will be needed with widespread use of neuraminidase inhibitors for treatment and prophylaxis during a pandemic...