Stephen J Wood

Summary

Affiliation: Western Hospital
Country: Australia

Publications

  1. ncbi request reprint Proton magnetic resonance spectroscopy in first episode psychosis and ultra high-risk individuals
    Stephen J Wood
    Melbourne Neuropsychiatry Centre, University of Melbourne and Sunshine Hospital, Melbourne, Australia
    Schizophr Bull 29:831-43. 2003
  2. doi request reprint Progressive gray matter reduction of the superior temporal gyrus during transition to psychosis
    Tsutomu Takahashi
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Australia
    Arch Gen Psychiatry 66:366-76. 2009
  3. doi request reprint Prevalence of large cavum septi pellucidi in ultra high-risk individuals and patients with psychotic disorders
    Tsutomu Takahashi
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Victoria, Australia
    Schizophr Res 105:236-44. 2008
  4. doi request reprint Superior temporal gyrus volume in antipsychotic-naive people at risk of psychosis
    Tsutomu Takahashi
    Melbourne Neuropsychiatry Centre, c o National Neuroscience Facility, 161 Barry Street, Carlton South, Victoria 3053, Australia
    Br J Psychiatry 196:206-11. 2010
  5. doi request reprint Anterior cingulate glutamate-glutamine levels predict symptom severity in women with obsessive-compulsive disorder
    Murat Yucel
    Melbourne Neuropsychiatry Centre, National Neuroscience Facility, Carlton South, Australia
    Aust N Z J Psychiatry 42:467-77. 2008
  6. ncbi request reprint Prediction of functional outcome 18 months after a first psychotic episode: a proton magnetic resonance spectroscopy study
    Stephen J Wood
    Melbourne Neuropsychiatry Centre, University of Melbourne, c o National Neuroscience Facility, 161 Barry Street, Carlton, Melbourne, Victoria 3053, Australia
    Arch Gen Psychiatry 63:969-76. 2006
  7. ncbi request reprint A 1H-MRS investigation of the medial temporal lobe in antipsychotic-naïve and early-treated first episode psychosis
    Stephen J Wood
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Australia
    Schizophr Res 102:163-70. 2008
  8. doi request reprint Insular cortex gray matter changes in individuals at ultra-high-risk of developing psychosis
    Tsutomu Takahashi
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Victoria, Australia
    Schizophr Res 111:94-102. 2009
  9. doi request reprint Anterior cingulate cortex abnormalities associated with a first psychotic episode in bipolar disorder
    Alex Fornito
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, School of Behavioural Science, University of Melbourne, National Neuroscience Facility, 161 Barry Street, Carlton South, VIC 3053, Australia
    Br J Psychiatry 194:426-33. 2009
  10. ncbi request reprint Hippocampal pathology in individuals at ultra-high risk for psychosis: a multi-modal magnetic resonance study
    Stephen J Wood
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Parkville, Vic, Australia
    Neuroimage 52:62-8. 2010

Detail Information

Publications103 found, 100 shown here

  1. ncbi request reprint Proton magnetic resonance spectroscopy in first episode psychosis and ultra high-risk individuals
    Stephen J Wood
    Melbourne Neuropsychiatry Centre, University of Melbourne and Sunshine Hospital, Melbourne, Australia
    Schizophr Bull 29:831-43. 2003
    ..This finding did not discriminate between those UHR individuals who later became psychotic and those who did not...
  2. doi request reprint Progressive gray matter reduction of the superior temporal gyrus during transition to psychosis
    Tsutomu Takahashi
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Australia
    Arch Gen Psychiatry 66:366-76. 2009
    ..It is unknown whether these progressive processes predate the onset of psychosis...
  3. doi request reprint Prevalence of large cavum septi pellucidi in ultra high-risk individuals and patients with psychotic disorders
    Tsutomu Takahashi
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Victoria, Australia
    Schizophr Res 105:236-44. 2008
    ..These findings suggest that the CSP is not a neurodevelopmental marker of psychosis and cast doubt over the notion that it plays a major role in the neurobiology of psychosis...
  4. doi request reprint Superior temporal gyrus volume in antipsychotic-naive people at risk of psychosis
    Tsutomu Takahashi
    Melbourne Neuropsychiatry Centre, c o National Neuroscience Facility, 161 Barry Street, Carlton South, Victoria 3053, Australia
    Br J Psychiatry 196:206-11. 2010
    ..Morphological abnormalities of the superior temporal gyrus have been consistently reported in schizophrenia, but the timing of their occurrence remains unclear...
  5. doi request reprint Anterior cingulate glutamate-glutamine levels predict symptom severity in women with obsessive-compulsive disorder
    Murat Yucel
    Melbourne Neuropsychiatry Centre, National Neuroscience Facility, Carlton South, Australia
    Aust N Z J Psychiatry 42:467-77. 2008
    ..The purpose of the present study was to investigate how ACC biochemistry in OCD varies as a function of gender, hemisphere, subregion, and symptomatology...
  6. ncbi request reprint Prediction of functional outcome 18 months after a first psychotic episode: a proton magnetic resonance spectroscopy study
    Stephen J Wood
    Melbourne Neuropsychiatry Centre, University of Melbourne, c o National Neuroscience Facility, 161 Barry Street, Carlton, Melbourne, Victoria 3053, Australia
    Arch Gen Psychiatry 63:969-76. 2006
    ..These studies have generally been negative, perhaps because gray and white matter volumes inaccurately assess the underlying dysfunction that might be predictive of outcome...
  7. ncbi request reprint A 1H-MRS investigation of the medial temporal lobe in antipsychotic-naïve and early-treated first episode psychosis
    Stephen J Wood
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Australia
    Schizophr Res 102:163-70. 2008
    ..Seemingly illness-related Cr/PCr elevations were also specific to the diagnosis of schizophrenia-spectrum disorder and seem worthy of future study...
  8. doi request reprint Insular cortex gray matter changes in individuals at ultra-high-risk of developing psychosis
    Tsutomu Takahashi
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Victoria, Australia
    Schizophr Res 111:94-102. 2009
    ..Whether these longitudinal changes are features of the disorder or related to treatment with antipsychotic medication remains to be determined...
  9. doi request reprint Anterior cingulate cortex abnormalities associated with a first psychotic episode in bipolar disorder
    Alex Fornito
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, School of Behavioural Science, University of Melbourne, National Neuroscience Facility, 161 Barry Street, Carlton South, VIC 3053, Australia
    Br J Psychiatry 194:426-33. 2009
    ....
  10. ncbi request reprint Hippocampal pathology in individuals at ultra-high risk for psychosis: a multi-modal magnetic resonance study
    Stephen J Wood
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Parkville, Vic, Australia
    Neuroimage 52:62-8. 2010
    ..However, standard measures of neuroanatomical disturbance do not appear to be predictive of later transition, and instead are likely to be non-specific and common in cases that later develop a non-psychotic disorder...
  11. ncbi request reprint Follow-up MRI study of the insular cortex in first-episode psychosis and chronic schizophrenia
    Tsutomu Takahashi
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Victoria, Australia
    Schizophr Res 108:49-56. 2009
    ....
  12. doi request reprint Corpus callosum shape alterations in individuals prior to the onset of psychosis
    Mark Walterfang
    Melbourne Neuropsychiatry Centre and Department of Psychiatry, University of Melbourne, North Western Mental Health Program, Sunshine Hospital, Melbourne, Australia
    Schizophr Res 103:1-10. 2008
    ..These changes may reflect primary pathology of orbitofrontal and medial frontal cortex, or deficits in anterior interhemispheric myelination...
  13. doi request reprint Anatomic abnormalities of the anterior cingulate cortex before psychosis onset: an MRI study of ultra-high-risk individuals
    Alex Fornito
    Department of Psychiatry, Melbourne Neuropsychiatry Centre, University of Melbourne, Carlton South, Victoria, Australia
    Biol Psychiatry 64:758-65. 2008
    ..In this study, we characterized prepsychotic ACC abnormalities in a sample of individuals at ultra-high-risk (UHR) for psychosis...
  14. doi request reprint Grey and white matter abnormalities are associated with impaired spatial working memory ability in first-episode schizophrenia
    Luca Cocchi
    Department of Psychiatry, Melbourne Neuropsychiatry Centre, The University of Melbourne and Melbourne Health, Melbourne, Australia
    Schizophr Res 115:163-72. 2009
    ....
  15. doi request reprint Orbitofrontal, amygdala and hippocampal volumes in teenagers with first-presentation borderline personality disorder
    Andrew M Chanen
    ORYGEN Research Centre, Department of Psychiatry, The University of Melbourne, Melbourne, Australia
    Psychiatry Res 163:116-25. 2008
    ..Hippocampal and amygdala volume reductions observed in adult BPD samples might develop during the course of the disorder, although longitudinal studies are needed to examine this...
  16. doi request reprint Caudate nucleus volume in individuals at ultra-high risk of psychosis: a cross-sectional magnetic resonance imaging study
    Katrina L Hannan
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Parkville, Victoria, Australia
    Psychiatry Res 182:223-30. 2010
    ..Future research should examine changes longitudinally together with analysis of shape to assess subregions of the caudate that connect with prefrontal cortex...
  17. doi request reprint Midline brain abnormalities in established bipolar affective disorder
    Tsutomu Takahashi
    Department of Psychiatry, University of Melbourne and Melbourne Health, Melbourne Neuropsychiatry Centre, Victoria, Australia
    J Affect Disord 122:301-5. 2010
    ..Morphologic changes of cortico-limbic regions have been reported in bipolar disorder, but it remains unclear whether midline brain abnormalities relevant to cortico-limbic connectivity are also present...
  18. doi request reprint Adhesio interthalamica in individuals at high-risk for developing psychosis and patients with psychotic disorders
    Tsutomu Takahashi
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Victoria, Australia
    Prog Neuropsychopharmacol Biol Psychiatry 32:1708-14. 2008
    ....
  19. ncbi request reprint Functional and biochemical alterations of the medial frontal cortex in obsessive-compulsive disorder
    Murat Yucel
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Victoria 3053, Australia
    Arch Gen Psychiatry 64:946-55. 2007
    ..However, the precise regions and the neural alterations associated with this abnormality remain unclear...
  20. doi request reprint Corpus callosum size and shape in first-episode affective and schizophrenia-spectrum psychosis
    Mark Walterfang
    Melbourne Neuropsychiatry Centre, University of Melbourne, Melbourne, Australia
    Psychiatry Res 173:77-82. 2009
    ..This suggests that schizoaffective disorder may represent two interacting illness processes or be mid-way along a continuum of these two broad categories of illness at first psychosis...
  21. doi request reprint Gray matter reduction of the superior temporal gyrus in patients with established bipolar I disorder
    Tsutomu Takahashi
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Victoria, Australia
    J Affect Disord 123:276-82. 2010
    ..Functional abnormalities of the superior temporal gyrus (STG) have been implicated in the pathophysiology of bipolar disorder, but magnetic resonance imaging (MRI) studies of this region have yielded inconsistent findings...
  22. doi request reprint Relational memory in first episode psychosis: implications for progressive hippocampal dysfunction after illness onset
    Cali F Bartholomeusz
    National Neuroscience Facility, Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne, Carlton South, Victoria, Australia
    Aust N Z J Psychiatry 45:206-13. 2011
    ....
  23. doi request reprint Superior temporal gyrus volume in teenagers with first-presentation borderline personality disorder
    Tsutomu Takahashi
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Melbourne, Australia
    Psychiatry Res 182:73-6. 2010
    ..Our preliminary findings might reflect the neurobiological heterogeneity of the disorder...
  24. doi request reprint An MRI study of the superior temporal subregions in first-episode patients with various psychotic disorders
    Tsutomu Takahashi
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Victoria, Australia
    Schizophr Res 113:158-66. 2009
    ..Our findings indicate that morphologic abnormalities of the STG gray matter are specific to schizophrenia among various psychotic disorders, implicating its role in the underlying pathophysiology of schizophrenia...
  25. doi request reprint Pituitary volume in patients with bipolar disorder and their first-degree relatives
    Tsutomu Takahashi
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Victoria, Australia
    J Affect Disord 124:256-61. 2010
    ..In addition, the contribution of genetic factors to the pituitary changes in BD remains largely unknown...
  26. doi request reprint An MRI study of pituitary volume and parasuicidal behavior in teenagers with first-presentation borderline personality disorder
    Martina Jovev
    ORYGEN Research Centre, Department of Psychiatry, The University of Melbourne, Melbourne, Australia
    Psychiatry Res 162:273-7. 2008
    ..Further studies are required using direct neuroendocrine measures and exploring other parameters of self-injurious behavior, such as recency of self-injurious behavior, intent to die and medical threat...
  27. ncbi request reprint Surface-based morphometry of the anterior cingulate cortex in first episode schizophrenia
    Alex Fornito
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Australia
    Hum Brain Mapp 29:478-89. 2008
    ....
  28. ncbi request reprint Fractionation of verbal memory impairment in schizophrenia and schizophreniform psychosis
    Stephen J Wood
    Melbourne Neuropsychiatry Centre, c National Neuroscience Facility, Carlton, Melbourne, Victoria, Australia
    Aust N Z J Psychiatry 41:732-9. 2007
    ..The impact of antipsychotic medications is also unclear. The purpose of the present paper was to investigate verbal memory performance in established schizophrenia (SZ) and first-episode schizophreniform psychosis (FE)...
  29. doi request reprint Insular cortex volume and impulsivity in teenagers with first-presentation borderline personality disorder
    Tsutomu Takahashi
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Melbourne, Australia
    Prog Neuropsychopharmacol Biol Psychiatry 33:1395-400. 2009
    ..Further studies are needed to clarify whether the potential relationship between the insular cortex volume and impulsivity is specific to BPD...
  30. doi request reprint Neuroprotective effects of ethyl-eicosapentaenoic acid in first episode psychosis: a longitudinal T2 relaxometry pilot study
    Stephen J Wood
    Melbourne Neuropsychiatry Centre, University of Melbourne, Australia
    Psychiatry Res 182:180-2. 2010
    ..There was an increase in T(2) in the placebo group but not in the E-EPA group, suggesting a neuroprotective effect of E-EPA treatment. In addition, the smaller the increase in T(2), the greater the improvement in negative symptoms...
  31. pmc Association between postnatal dexamethasone for treatment of bronchopulmonary dysplasia and brain volumes at adolescence in infants born very preterm
    Jeanie L Y Cheong
    Neonatal Services, Royal Women s Hospital, Melbourne, Australia Victorian Infant Brain Studies, Murdoch Childrens Research Institute, Melbourne, Australia Department of Obstetrics and Gynecology, University of Melbourne, Melbourne, Australia Electronic address
    J Pediatr 164:737-743.e1. 2014
    ..To compare brain volumes in adolescents who were born extremely preterm (<28 weeks gestation) who had received postnatal dexamethasone, and to determine if there was a postnatal dexamethasone dose-response effect on brain volumes...
  32. pmc Phenylthiocarbamide (PTC) perception in ultra-high risk for psychosis participants who develop schizophrenia: testing the evidence for an endophenotypic marker
    Warrick J Brewer
    Orygen Youth Health Research Centre, University of Melbourne, Melbourne, Australia
    Psychiatry Res 199:8-11. 2012
    ....
  33. doi request reprint Inhibitory control in young adolescents: the role of sex, intelligence, and temperament
    Murat Yucel
    The University of Melbourne, Melbourne Health, Melbourne, Victoria, Australia
    Neuropsychology 26:347-56. 2012
    ..However, sex differences in inhibitory control are often not expressed experimentally during task performance. Here, we sought to examine how sex, temperament, and intelligence are related to different aspects of inhibitory control...
  34. doi request reprint Medial temporal lobe glutathione concentration in first episode psychosis: a 1H-MRS investigation
    Stephen J Wood
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Australia
    Neurobiol Dis 33:354-7. 2009
    ..This study provides further evidence of significant perturbations in brain GSH in first episode psychosis, and supports a broader involvement of GSH in the pathophysiology of schizophrenia...
  35. ncbi request reprint Attentional set-shifting ability in first-episode and established schizophrenia: Relationship to working memory
    Christos Pantelis
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Sunshine Hospital, St Albans, Victoria 3021, Australia
    Schizophr Res 112:104-13. 2009
    ..Longitudinal studies assessing these cognitive functions from illness onset or in prepsychotic individuals are required...
  36. doi request reprint Anatomical abnormalities of the anterior cingulate and paracingulate cortex in patients with bipolar I disorder
    Alex Fornito
    Melbourne Neuropsychiatry Centre, The University of Melbourne, Melbourne, Australia
    Psychiatry Res 162:123-32. 2008
    ..These findings suggest that bipolar disorder is associated with more pronounced changes in the PaC, and that reliance on volumetric measures alone may obscure more subtle differences...
  37. doi request reprint Increased pituitary volume in patients with established bipolar affective disorder
    Tsutomu Takahashi
    Department of Psychiatry, Melbourne Neuropsychiatry Centre, University of Melbourne and Melbourne Health, Victoria, Australia
    Prog Neuropsychopharmacol Biol Psychiatry 33:1245-9. 2009
    ..psychotic and nonpsychotic). Pituitary volume was larger in females than in males for both groups. These results support previous neuroendocrine findings that implicate HPA axis dysfunction in the core pathophysiological process of BD...
  38. pmc Anatomical abnormalities of the anterior cingulate cortex in schizophrenia: bridging the gap between neuroimaging and neuropathology
    Alex Fornito
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne, Victoria, Australia
    Schizophr Bull 35:973-93. 2009
    ..We discuss the potential mechanisms that might facilitate integration of these findings and consider strategies for future research...
  39. doi request reprint Diagnostic specificity of the insular cortex abnormalities in first-episode psychotic disorders
    Tsutomu Takahashi
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Victoria, Australia
    Prog Neuropsychopharmacol Biol Psychiatry 33:651-7. 2009
    ..These findings suggest that the widespread volume reduction of the insular cortex is specific to established schizophrenia, implicating its role in the neurobiology of clinical characteristics associated with schizophrenia...
  40. ncbi request reprint Evidence for neuronal dysfunction in the anterior cingulate of patients with schizophrenia: a proton magnetic resonance spectroscopy study at 3 T
    Stephen J Wood
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne, Australia
    Schizophr Res 94:328-31. 2007
    ..Anterior cingulate involvement in schizophrenia is likely to be a result of neuronal loss or dysfunction...
  41. doi request reprint Insular cortex volume in established bipolar affective disorder: a preliminary MRI study
    Tsutomu Takahashi
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, 161 Barry Street, Carlton South, Victoria 3053, Australia
    Psychiatry Res 182:187-90. 2010
    ....
  42. ncbi request reprint Neuroanatomical abnormalities before and after onset of psychosis: a cross-sectional and longitudinal MRI comparison
    Christos Pantelis
    Cognitive Neuropsychiatry Research and Academic Unit, and Melbourne Neuropsychiatry Centre, Mental Health Programme, Department of Psychiatry, University of Melbourne and Sunshine Hospital, Victoria, Melbourne, Australia
    Lancet 361:281-8. 2003
    ..We investigated this issue with MRI to study people with prodromal symptoms who are at ultra high-risk for the development of psychosis...
  43. doi request reprint The effect of atypical antipsychotics on pituitary gland volume in patients with first-episode psychosis: a longitudinal MRI study
    John Paul Nicolo
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Australia
    Schizophr Res 116:49-54. 2010
    ..Qualifying and quantifying the effect of atypical antipsychotics on the volume of the pituitary gland will determine whether this measure is valid as a future estimate of HPA-axis activation in psychotic populations...
  44. ncbi request reprint Memory impairments identified in people at ultra-high risk for psychosis who later develop first-episode psychosis
    Warrick J Brewer
    ORYGEN Research Centre, Melbourne, Australia
    Am J Psychiatry 162:71-8. 2005
    ..While cognitive deficits are frequently reported in psychotic disorders, it is unclear whether these impairments predate the onset of illness and to what extent they are predictive of later transition to psychosis...
  45. pmc Hippocampal shape variations at term equivalent age in very preterm infants compared with term controls: perinatal predictors and functional significance at age 7
    Deanne K Thompson
    Murdoch Childrens Research Institute, Royal Children s Hospital, Melbourne, Australia
    Neuroimage 70:278-87. 2013
    ..This study provides further insight into early hippocampal development and the nature of hippocampal abnormalities in prematurity...
  46. ncbi request reprint Hippocampal and anterior cingulate morphology in subjects at ultra-high-risk for psychosis: the role of family history of psychotic illness
    Stephen J Wood
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne, National Neuroscience Facility, 161 Barry Street, Carlton South VIC 3053, Australia
    Schizophr Res 75:295-301. 2005
    ..Some appear to predate the illness and may be genetic in origin, while others are associated with the onset of the disorder...
  47. ncbi request reprint Midline brain structures in teenagers with first-presentation borderline personality disorder
    Tsutomu Takahashi
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Melbourne, Australia
    Prog Neuropsychopharmacol Biol Psychiatry 33:842-6. 2009
    ..These preliminary findings suggest that ongoing neuroimaging studies should further evaluate a potential involvement of midline brain structures in the pathogenesis of BPD...
  48. pmc Progressive changes in the development toward schizophrenia: studies in subjects at increased symptomatic risk
    Stephen J Wood
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne, Australia
    Schizophr Bull 34:322-9. 2008
    ..Active changes during transition to illness may present the potential to intervene and ameliorate these changes with potential benefit clinically...
  49. pmc Contribution of brain size to IQ and educational underperformance in extremely preterm adolescents
    Jeanie L Y Cheong
    Neonatal Services, Royal Women s Hospital, Melbourne, Australia Victorian Infant Brain Studies, Murdoch Childrens Research Institute, Melbourne, Australia Department of Obstetrics and Gynaecology, University of Melbourne, Melbourne, Australia
    PLoS ONE 8:e77475. 2013
    ....
  50. pmc Structural abnormalities in the cuneus associated with Herpes Simplex Virus (type 1) infection in people at ultra high risk of developing psychosis
    Thomas J Whitford
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Carlton South, VIC 3053, Australia
    Schizophr Res 135:175-80. 2012
    ....
  51. ncbi request reprint Variability of the paracingulate sulcus and morphometry of the medial frontal cortex: associations with cortical thickness, surface area, volume, and sulcal depth
    Alex Fornito
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne, Melbourne, Australia
    Hum Brain Mapp 29:222-36. 2008
    ....
  52. pmc Progressive brain structural changes mapped as psychosis develops in 'at risk' individuals
    Daqiang Sun
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Parkville, Victoria, Australia
    Schizophr Res 108:85-92. 2009
    ..We hypothesized that progressive volume loss occurs in prefrontal regions during the transition to psychosis...
  53. doi request reprint Abnormal white matter microstructure in schizophrenia: a voxelwise analysis of axial and radial diffusivity
    Marc L Seal
    Melbourne Neuropsychiatry Centre, The University of Melbourne, Victoria, Australia
    Schizophr Res 101:106-10. 2008
    ..This finding suggests that the loss of white matter integrity in schizophrenia is the result of demyelination and/or changes to the axonal cytoskeleton rather than gross axonal damage...
  54. ncbi request reprint Olfactory sensitivity through the course of psychosis: Relationships to olfactory identification, symptomatology and the schizophrenia odour
    Warrick J Brewer
    ORYGEN Research Centre, Melbourne, Victoria, Australia
    Psychiatry Res 149:97-104. 2007
    ..This may be linked to olfactory habituation effects, abnormal chemical processing or a genetic predisposition...
  55. ncbi request reprint Morphology of the paracingulate sulcus and executive cognition in schizophrenia
    Alex Fornito
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne, National Neuroscience Facility, Levels 2 and 3, Alan Gilbert Building, 161 Barry St, Carlton South, Victoria 3053, Australia
    Schizophr Res 88:192-7. 2006
    ..This suggests that prior reports of impaired performance on such tasks in schizophrenia may be partly explained by the reduced frequency of a leftward PCS asymmetry in this population...
  56. doi request reprint Neurocognitive functioning in the prodrome of mania--an exploratory study
    Aswin Ratheesh
    ORYGEN Youth Health, Melbourne, Australia
    J Affect Disord 147:441-5. 2013
    ..Cognitive deficits have been well documented in individuals with bipolar disorder (BD) after the first episode of mania. However, little is known about the presence of such deficits prior to the initial manic episode...
  57. ncbi request reprint Pituitary volume predicts future transition to psychosis in individuals at ultra-high risk of developing psychosis
    Belinda Garner
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne, Royal Melbourne Hospital, Melbourne, Australia
    Biol Psychiatry 58:417-23. 2005
    ..We examined pituitary volume before the onset of psychosis in subjects who were at ultra-high risk (UHR) for developing psychosis...
  58. ncbi request reprint Long-term follow-up of a group at ultra high risk ("prodromal") for psychosis: the PACE 400 study
    Barnaby Nelson
    Orygen Youth Health Research Centre, Centre for Youth Mental Health, University of Melbourne, Melbourne, Australia
    JAMA Psychiatry 70:793-802. 2013
    ..The ultra high-risk (UHR) criteria were introduced to prospectively identify patients at high risk of psychotic disorder. Although the short-term outcome of UHR patients has been well researched, the long-term outcome is not known...
  59. doi request reprint Sulcogyral patterns and morphological abnormalities of the orbitofrontal cortex in psychosis
    Cali F Bartholomeusz
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, 161 Barry Street, Carlton South, Victoria 3053, Australia
    Prog Neuropsychopharmacol Biol Psychiatry 44:168-77. 2013
    ..This finding, along with compromised orbitofrontal sulci thickness, may reflect early abnormalities in cortical development and point toward a possible endophenotypic risk marker of schizophrenia-spectrum disorders...
  60. pmc The impact of cannabis use on cognitive functioning in patients with schizophrenia: a meta-analysis of existing findings and new data in a first-episode sample
    Murat Yucel
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, National Neuroscience Facility, Alan Gilbert Building, 161 Barry Street, Carlton South, Victoria 3053, Australia
    Schizophr Bull 38:316-30. 2012
    ....
  61. pmc Optimizing hippocampal segmentation in infants utilizing MRI post-acquisition processing
    Deanne K Thompson
    Critical Care and Neurosciences, Murdoch Childrens Research Institute, Royal Children s Hospital, Melbourne, Australia
    Neuroinformatics 10:173-80. 2012
    ....
  62. ncbi request reprint Impairment of olfactory identification ability in individuals at ultra-high risk for psychosis who later develop schizophrenia
    Warrick J Brewer
    Department of Psychiatry, University of Melbourne, Melbourne, Australia
    Am J Psychiatry 160:1790-4. 2003
    ..Previous investigation has revealed stable olfactory identification deficits in neuroleptic-naive patients experiencing a first episode of psychosis, but it is unknown if these deficits predate illness onset...
  63. ncbi request reprint A manual and automated MRI study of anterior cingulate and orbito-frontal cortices, and caudate nucleus in obsessive-compulsive disorder: comparison with healthy controls and patients with schizophrenia
    Jem Riffkin
    Melbourne Neuropsychiatry Centre, University of Melbourne and Sunshine Hospital, Melbourne, Victoria, Australia
    Psychiatry Res 138:99-113. 2005
    ..The findings suggest that in contrast to findings in SCZ, there are very few (if any) gross structural anomalies in OCD...
  64. doi request reprint Neuroanatomical abnormalities in schizophrenia: a multimodal voxelwise meta-analysis and meta-regression analysis
    Emre Bora
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Level 3, National Neuroscience Facility, Alan Gilbert Building, 161, Barry St, Carlton South, Vic, 3053, Australia
    Schizophr Res 127:46-57. 2011
    ..However, the available findings are biased towards characteristics of schizophrenia samples with poor prognosis...
  65. ncbi request reprint Early processing deficits in object working memory in first-episode schizophreniform psychosis and established schizophrenia
    Birgit Mathes
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Sunshine Hospital, Melbourne, Australia
    Psychol Med 35:1053-62. 2005
    ..While there are many studies showing working-memory deficits in schizophrenia there are only a few that disentangle impairments for working-memory subprocesses such as perceptual, attentional, mnemonic and executive function...
  66. doi request reprint Markers of vulnerability to obsessive-compulsive disorder in an ultra-high risk sample of patients who developed psychosis
    Leonardo F Fontenelle
    Melbourne Neuropsychiatry Centre, University of Melbourne and Melbourne Health, Carlton South, Australia
    Early Interv Psychiatry 6:201-6. 2012
    ..The study aims to identify markers of vulnerability to obsessive-compulsive disorder (OCD) in an ultra-high risk sample of patients who developed psychosis...
  67. doi request reprint Neuroimaging and treatment evidence for clinical staging in psychotic disorders: from the at-risk mental state to chronic schizophrenia
    Stephen J Wood
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Melbourne, Australia
    Biol Psychiatry 70:619-25. 2011
    ..For all three, the balance of evidence supports the predictions of the staging model. However, there are a number of alternative explanations for these findings, including the effects of medication and symptom heterogeneity...
  68. ncbi request reprint The influence of sulcal variability on morphometry of the human anterior cingulate and paracingulate cortex
    Alex Fornito
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne, Australia
    Neuroimage 33:843-54. 2006
    ....
  69. ncbi request reprint Increased duration of illness is associated with reduced volume in right medial temporal/anterior cingulate grey matter in patients with chronic schizophrenia
    Dennis Velakoulis
    Cognitive Neuropsychiatry Research and Academic Unit, Department of Psychiatry, University of Melbourne and Sunshine Hospital, St Albans, Australia
    Schizophr Res 57:43-9. 2002
    ..The inverse correlation between right frontal, temporal and cerebellar volumes and the time since the onset of schizophrenia could reflect progressive tissue loss following the first episode of the disorder...
  70. ncbi request reprint State, trait and biochemical influences on human anterior cingulate function
    Murat Yucel
    Melbourne Neuropsychiatry Centre, Australia
    Neuroimage 34:1766-73. 2007
    ..They also highlight the importance of considering enduring personal characteristics when mapping human brain-behavior relationships...
  71. ncbi request reprint The localization and lateralization of memory deficits in children with temporal lobe epilepsy
    Linda M Gonzalez
    Australian Centre for Child Neuropsychology Studies, Murdoch Children s Research Institute, Melbourne, Australia
    Epilepsia 48:124-32. 2007
    ..Further, differences between mesial and lateral subgroups have not been adequately examined. This study aimed to discern more specific patterns of memory impairment in children with TLE...
  72. doi request reprint Working memory load improves early stages of independent visual processing
    Luca Cocchi
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Australia
    Neuropsychologia 49:92-102. 2011
    ..More broadly, our findings are in line with theoretical models implicating the engagement of frontal regions in synchronizing and optimizing mnemonic and perceptual resources towards multiple goals...
  73. ncbi request reprint A longitudinal study of obsessive-compulsive disorder in individuals at ultra-high risk for psychosis
    Leonardo F Fontenelle
    Melbourne Neuropsychiatry Centre, University of Melbourne and Melbourne Health, Australia
    J Psychiatr Res 45:1140-5. 2011
    ....
  74. ncbi request reprint Diseases of white matter and schizophrenia-like psychosis
    Mark Walterfang
    Melbourne Neuropsychiatry Centre, Level 2, John Cade Building, Royal Melbourne Hospital, Melbourne, Victoria 3050, Australia
    Aust N Z J Psychiatry 39:746-56. 2005
    ..To analyse the available data regarding the presentation of psychosis in diseases of central nervous system (CNS) white matter...
  75. ncbi request reprint Brain changes during the onset of schizophrenia: implications for neurodevelopmental theories
    Stephen J Wood
    Melbourne Neuropsychiatry Centre, University of Melbourne and Melbourne Health, Melbourne, Vic
    Med J Aust 190:S10-3. 2009
    ..Although the cause of these changes is unclear, they challenge the conventional neurodevelopmental model of schizophrenia...
  76. ncbi request reprint Morphology of the anterior cingulate cortex in young men at ultra-high risk of developing a psychotic illness
    Murat Yucel
    Department of Psychiatry, University of Melbourne, Parkville, Victoria, Australia
    Br J Psychiatry 182:518-24. 2003
    ..The anterior cingulate cortex (ACC) is consistently implicated in the pathophysiology of schizophrenia, and our own work has identified morphological anomalies in the ACC of people with this disorder...
  77. pmc Anterior cingulate dysfunction: implications for psychiatric disorders?
    Murat Yucel
    Melbourne Neuropsychiatry Centre Sunshine Hospital, Department of Psychiatry, University of Melbourne, Parkville, Australia
    J Psychiatry Neurosci 28:350-4. 2003
  78. ncbi request reprint Neuropsychological functioning in children with early-treated phenylketonuria: impact of white matter abnormalities
    Peter J Anderson
    Department of Psychology, Royal Children s Hospital, Melbourne, Victoria, Australia
    Dev Med Child Neurol 46:230-8. 2004
    ..However, children with no detectable, or mild WMAs, also displayed cognitive problems, indicating that neuropsychological functioning in children with ETPKU is determined by a complex interaction of biological and environmental factors...
  79. ncbi request reprint Paracingulate morphologic differences in males with established schizophrenia: a magnetic resonance imaging morphometric study
    Murat Yucel
    Cognitive Neuropsychiatry Research and Academic Unit, Department of Psychiatry, The University of Melbourne, Sunshine Hospital, Melbourne, Victoria, Australia
    Biol Psychiatry 52:15-23. 2002
    ..Given the evidence showing an absence or reversal of normal anatomical asymmetries in patients with schizophrenia, the current study examined the anterior cingulate cortex sulcal-gyral patterns in patients with schizophrenia...
  80. ncbi request reprint Neuropathological, neurogenetic and neuroimaging evidence for white matter pathology in schizophrenia
    Mark Walterfang
    Melbourne Neuropsychiatry Centre, University of Melbourne, Victoria, Australia
    Neurosci Biobehav Rev 30:918-48. 2006
    ....
  81. ncbi request reprint Are neuropsychological impairments in children with early-treated phenylketonuria (PKU) related to white matter abnormalities or elevated phenylalanine levels?
    Peter J Anderson
    Critical Care and Neurosciences, Murdoch Childrens Research Institute, Melbourne, Australia
    Dev Neuropsychol 32:645-68. 2007
    ..Our findings also offer some support for dopamine depletion in the prefrontal cortex, however adverse consequences as a result of norepinephrine and serotonin deficiencies should not be discounted...
  82. ncbi request reprint Neurobiology of schizophrenia spectrum disorders: the role of oxidative stress
    Stephen J Wood
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Melbourne, Australia
    Ann Acad Med Singapore 38:396-6. 2009
    ..We argue that a better understanding of the mechanisms and pathways underlying oxidative stress will assist in developing the therapeutic potential of this area...
  83. ncbi request reprint Hippocampal and amygdala volumes according to psychosis stage and diagnosis: a magnetic resonance imaging study of chronic schizophrenia, first-episode psychosis, and ultra-high-risk individuals
    Dennis Velakoulis
    Melbourne Neuropsychiatry Centre and Department of Psychiatry, University of Melbourne, Australia
    Arch Gen Psychiatry 63:139-49. 2006
    ..These studies have been limited by small samples and the absence of patients early in the course of illness...
  84. ncbi request reprint Anterior cingulate activation during Stroop task performance: a PET to MRI coregistration study of individual patients with schizophrenia
    Murat Yucel
    Cognitive Neuropsychiatry Research and Academic Unit, Department of Psychiatry, Howard Florey Institute, University of Melbourne, Victoria, Australia
    Am J Psychiatry 159:251-4. 2002
    ....
  85. ncbi request reprint Evidence of altered prefrontal-thalamic circuitry in schizophrenia: an optimized diffusion MRI study
    Stephen E Rose
    Centre for Magnetic Resonance, University of Queensland, Brisbane 4072, Australia
    Neuroimage 32:16-22. 2006
    ..001). This study has shown for the first time that MD measures offer an alternative strategy for investigating altered prefrontal-thalamic circuitry in schizophrenia...
  86. pmc Generalized and specific cognitive performance in clinical high-risk cohorts: a review highlighting potential vulnerability markers for psychosis
    Warrick J Brewer
    ORYGEN Research Centre and Early Psychosis Prevention and Intervention Centre, EPPIC, Department of Psychiatry, University of Melbourne, Australia
    Schizophr Bull 32:538-55. 2006
    ..Delineation of the relationship between specific cognitive ability and symptoms from data-driven approaches may improve our understanding of the role of cognition during psychosis onset...
  87. doi request reprint Cognitive decline following psychosis onset: data from the PACE clinic
    Stephen J Wood
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne, c o National Neuroscience Facility, 161 Barry Street, Carlton South, VIC 3053 Australia
    Br J Psychiatry Suppl 51:s52-7. 2007
    ..The origin of cognitive impairments in psychotic disorders is still unclear. Although some deficits are apparent prior to the onset of frank illness, it is unknown if they progress...
  88. doi request reprint Neuroanatomical correlates of temperament in early adolescents
    Sarah Whittle
    Department of Psychiatry, University of Melbourne, Victoria 3052, Australia
    J Am Acad Child Adolesc Psychiatry 47:682-93. 2008
    ..In the present study, we examined the relation between four core temperament dimensions and anatomically defined regions of the limbic and prefrontal cortices...
  89. ncbi request reprint Implications of lipid biology for the pathogenesis of schizophrenia
    Gregor E Berger
    Early Psychosis Prevention and Intervention Centre, MH SKY EPPIC, Victoria
    Aust N Z J Psychiatry 36:355-66. 2002
    ..Both aspects are proposed as being important in the pathogenesis of schizophrenia. The purpose of this paper is to examine the implications of lipid biology, in particular the role of essential fatty acids (EFA), for schizophrenia...
  90. ncbi request reprint Patient education and informed consent in head and neck surgery
    Yvonne Chan
    Department of Otolaryngology, Wharton Head and Neck Centre, Princess Margaret Hospital, University Health Network, Toronto, Ontario, Canada
    Arch Otolaryngol Head Neck Surg 128:1269-74. 2002
    ..To examine the effects of an educational intervention, in the form of printed material, on patient knowledge and recall of possible risks from parotidectomy or thyroidectomy...
  91. ncbi request reprint Normative data from the CANTAB. I: development of executive function over the lifespan
    Cinzia R De Luca
    Sunshine Hospital and Department of Psychiatry, University of Melbourne, Australia
    J Clin Exp Neuropsychol 25:242-54. 2003
    ..Declines in performance on all tasks were revealed for the 50-64 year old sample, providing support for the vulnerability of executive skills to normal aging...
  92. doi request reprint Morphology of the corpus callosum at different stages of schizophrenia: cross-sectional study in first-episode and chronic illness
    Mark Walterfang
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne North Western Mental Health Program, Sunshine Hospital, Royal Melbourne Hospital, Melbourne corrected
    Br J Psychiatry 192:429-34. 2008
    ..The shape of the corpus callosum may differ in schizophrenia, although no study has compared first-episode with established illness...
  93. ncbi request reprint Early and late neurodevelopmental disturbances in schizophrenia and their functional consequences
    Christos Pantelis
    Cognitive Neuropsychiatry Research and Academic Unit, Sunshine Hospital, 176 Furlong Road, St Albans, 3021, Victoria, Australia
    Aust N Z J Psychiatry 37:399-406. 2003
    ..In this paper we review the timing of structural changes in schizophrenia and argue that schizophrenia is a neuro-developmental disorder with limited progressive brain changes occurring during the evolution and early phase of psychosis...
  94. doi request reprint Neonate hippocampal volumes: prematurity, perinatal predictors, and 2-year outcome
    Deanne K Thompson
    Howard Florey Institute, Centre for Neuroscience, University of Melbourne, Melbourne, Victoria, Australia
    Ann Neurol 63:642-51. 2008
    ..To compare preterm (PT) and full-term (FT) infant hippocampal volumes and to investigate the relations among PT hippocampal volume, perinatal risk factors, and neurodevelopmental outcome...
  95. doi request reprint The Observer Memory Questionnaire-Parent Form: introducing a new measure of everyday memory for children
    Linda M Gonzalez
    Royal Children s Hospital, Department of Psychology, Parkville, Victoria, 3052, Australia
    J Int Neuropsychol Soc 14:337-42. 2008
    ..Everyday memory ratings were related to a wider range of neuropsychological measures in this group. Findings are encouraging in terms of the properties of the OMQ-PF and suggest further development of the scale is warranted...
  96. ncbi request reprint Pituitary volume in psychosis
    Carmine M Pariante
    Division of Psychological Medicine, Institute of Psychiatry, King s College London, UK
    Br J Psychiatry 185:5-10. 2004
    ..Patients with psychosis have activation of the hypothalamic-pituitary-adrenal (HPA) axis during the acute phase of the psychosis. Whether this has any morphological consequences for the pituitary gland is currently unknown...
  97. ncbi request reprint The transition to psychosis: risk factors and brain changes
    Stephen J Wood
    Epidemiol Psichiatr Soc 13:137-40. 2004
  98. ncbi request reprint Structural brain imaging evidence for multiple pathological processes at different stages of brain development in schizophrenia
    Christos Pantelis
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne, Royal Melbourne Hospital, Sunshine Hospital, Victoria
    Schizophr Bull 31:672-96. 2005
    ....
  99. ncbi request reprint Neurobiology of early psychosis
    Matcheri S Keshavan
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University, UCH 9B, 4201 St Antoine Boulevard, Detroit, MI, USA
    Br J Psychiatry Suppl 48:s8-18. 2005
    ..Neurobiological studies of the early course of psychoses, such as schizophrenia, allow investigation of pathophysiology without the confounds of illness chronicity and treatment...
  100. ncbi request reprint Sustained attention in young people at high risk of psychosis does not predict transition to psychosis
    Shona M Francey
    PACE Clinic, ORYGEN Youth Health, Locked Bag 10, Parkville, 3052, Australia
    Schizophr Res 79:127-36. 2005
    ..These results support sustained attention as an indicator of vulnerability to psychosis, but suggest that CPT-IP performance does not help to predict transition to psychosis in an ultra high-risk group...
  101. ncbi request reprint Ethyl-eicosapentaenoic acid in first-episode psychosis: a randomized, placebo-controlled trial
    Gregor E Berger
    ORYGEN Research Centre incorporating the Early Psychosis Prevention and Intervention Centre EPPIC, University of Melbourne, Australia
    J Clin Psychiatry 68:1867-75. 2007
    ..To investigate if ethyl-eicosapentaenoic acid (E-EPA) augmentation improves antipsychotic efficacy and tolerability in first-episode psychosis (FEP)...