Research Topics
| Stephen J WoodSummaryAffiliation: Western Hospital Country: Australia Publications
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Publications
Proton magnetic resonance spectroscopy in first episode psychosis and ultra high-risk individualsStephen J Wood
Melbourne Neuropsychiatry Centre, University of Melbourne and Sunshine Hospital, Melbourne, Australia
Schizophr Bull 29:831-43. 2003..This finding did not discriminate between those UHR individuals who later became psychotic and those who did not...
Progressive gray matter reduction of the superior temporal gyrus during transition to psychosisTsutomu Takahashi
Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Australia
Arch Gen Psychiatry 66:366-76. 2009..It is unknown whether these progressive processes predate the onset of psychosis...- Prevalence of large cavum septi pellucidi in ultra high-risk individuals and patients with psychotic disordersTsutomu Takahashi
Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Victoria, Australia
Schizophr Res 105:236-44. 2008..These findings suggest that the CSP is not a neurodevelopmental marker of psychosis and cast doubt over the notion that it plays a major role in the neurobiology of psychosis... - Superior temporal gyrus volume in antipsychotic-naive people at risk of psychosisTsutomu Takahashi
Melbourne Neuropsychiatry Centre, c o National Neuroscience Facility, 161 Barry Street, Carlton South, Victoria 3053, Australia
Br J Psychiatry 196:206-11. 2010..Morphological abnormalities of the superior temporal gyrus have been consistently reported in schizophrenia, but the timing of their occurrence remains unclear... - Anterior cingulate glutamate-glutamine levels predict symptom severity in women with obsessive-compulsive disorderMurat Yucel
Melbourne Neuropsychiatry Centre, National Neuroscience Facility, Carlton South, Australia
Aust N Z J Psychiatry 42:467-77. 2008..The purpose of the present study was to investigate how ACC biochemistry in OCD varies as a function of gender, hemisphere, subregion, and symptomatology... - Prediction of functional outcome 18 months after a first psychotic episode: a proton magnetic resonance spectroscopy studyStephen J Wood
Melbourne Neuropsychiatry Centre, University of Melbourne, c o National Neuroscience Facility, 161 Barry Street, Carlton, Melbourne, Victoria 3053, Australia
Arch Gen Psychiatry 63:969-76. 2006..These studies have generally been negative, perhaps because gray and white matter volumes inaccurately assess the underlying dysfunction that might be predictive of outcome... - Insular cortex gray matter changes in individuals at ultra-high-risk of developing psychosisTsutomu Takahashi
Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Victoria, Australia
Schizophr Res 111:94-102. 2009..Whether these longitudinal changes are features of the disorder or related to treatment with antipsychotic medication remains to be determined... - Hippocampal pathology in individuals at ultra-high risk for psychosis: a multi-modal magnetic resonance studyStephen J Wood
Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Parkville, Vic, Australia
Neuroimage 52:62-8. 2010..However, standard measures of neuroanatomical disturbance do not appear to be predictive of later transition, and instead are likely to be non-specific and common in cases that later develop a non-psychotic disorder... - Anterior cingulate cortex abnormalities associated with a first psychotic episode in bipolar disorderAlex Fornito
Melbourne Neuropsychiatry Centre, Department of Psychiatry, School of Behavioural Science, University of Melbourne, National Neuroscience Facility, 161 Barry Street, Carlton South, VIC 3053, Australia
Br J Psychiatry 194:426-33. 2009.... - A 1H-MRS investigation of the medial temporal lobe in antipsychotic-naïve and early-treated first episode psychosisStephen J Wood
Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Australia
Schizophr Res 102:163-70. 2008..Seemingly illness-related Cr/PCr elevations were also specific to the diagnosis of schizophrenia-spectrum disorder and seem worthy of future study... - Anatomic abnormalities of the anterior cingulate cortex before psychosis onset: an MRI study of ultra-high-risk individualsAlex Fornito
Department of Psychiatry, Melbourne Neuropsychiatry Centre, University of Melbourne, Carlton South, Victoria, Australia
Biol Psychiatry 64:758-65. 2008..In this study, we characterized prepsychotic ACC abnormalities in a sample of individuals at ultra-high-risk (UHR) for psychosis... - Corpus callosum shape alterations in individuals prior to the onset of psychosisMark Walterfang
Melbourne Neuropsychiatry Centre and Department of Psychiatry, University of Melbourne, North Western Mental Health Program, Sunshine Hospital, Melbourne, Australia
Schizophr Res 103:1-10. 2008..These changes may reflect primary pathology of orbitofrontal and medial frontal cortex, or deficits in anterior interhemispheric myelination... - Follow-up MRI study of the insular cortex in first-episode psychosis and chronic schizophreniaTsutomu Takahashi
Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Victoria, Australia
Schizophr Res 108:49-56. 2009.... - Midline brain abnormalities in established bipolar affective disorderTsutomu Takahashi
Department of Psychiatry, University of Melbourne and Melbourne Health, Melbourne Neuropsychiatry Centre, Victoria, Australia
J Affect Disord 122:301-5. 2010..Morphologic changes of cortico-limbic regions have been reported in bipolar disorder, but it remains unclear whether midline brain abnormalities relevant to cortico-limbic connectivity are also present... - Grey and white matter abnormalities are associated with impaired spatial working memory ability in first-episode schizophreniaLuca Cocchi
Department of Psychiatry, Melbourne Neuropsychiatry Centre, The University of Melbourne and Melbourne Health, Melbourne, Australia
Schizophr Res 115:163-72. 2009.... - Orbitofrontal, amygdala and hippocampal volumes in teenagers with first-presentation borderline personality disorderAndrew M Chanen
ORYGEN Research Centre, Department of Psychiatry, The University of Melbourne, Melbourne, Australia
Psychiatry Res 163:116-25. 2008..Hippocampal and amygdala volume reductions observed in adult BPD samples might develop during the course of the disorder, although longitudinal studies are needed to examine this... - Functional and biochemical alterations of the medial frontal cortex in obsessive-compulsive disorderMurat Yucel
Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Victoria 3053, Australia
Arch Gen Psychiatry 64:946-55. 2007..However, the precise regions and the neural alterations associated with this abnormality remain unclear... - Corpus callosum size and shape in first-episode affective and schizophrenia-spectrum psychosisMark Walterfang
Melbourne Neuropsychiatry Centre, University of Melbourne, Melbourne, Australia
Psychiatry Res 173:77-82. 2009..This suggests that schizoaffective disorder may represent two interacting illness processes or be mid-way along a continuum of these two broad categories of illness at first psychosis... - Adhesio interthalamica in individuals at high-risk for developing psychosis and patients with psychotic disordersTsutomu Takahashi
Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Victoria, Australia
Prog Neuropsychopharmacol Biol Psychiatry 32:1708-14. 2008.... - Caudate nucleus volume in individuals at ultra-high risk of psychosis: a cross-sectional magnetic resonance imaging studyKatrina L Hannan
Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Parkville, Victoria, Australia
Psychiatry Res 182:223-30. 2010..Future research should examine changes longitudinally together with analysis of shape to assess subregions of the caudate that connect with prefrontal cortex... - Gray matter reduction of the superior temporal gyrus in patients with established bipolar I disorderTsutomu Takahashi
Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Victoria, Australia
J Affect Disord 123:276-82. 2010..Functional abnormalities of the superior temporal gyrus (STG) have been implicated in the pathophysiology of bipolar disorder, but magnetic resonance imaging (MRI) studies of this region have yielded inconsistent findings... - An MRI study of pituitary volume and parasuicidal behavior in teenagers with first-presentation borderline personality disorderMartina Jovev
ORYGEN Research Centre, Department of Psychiatry, The University of Melbourne, Melbourne, Australia
Psychiatry Res 162:273-7. 2008..Further studies are required using direct neuroendocrine measures and exploring other parameters of self-injurious behavior, such as recency of self-injurious behavior, intent to die and medical threat... - Pituitary volume in patients with bipolar disorder and their first-degree relativesTsutomu Takahashi
Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Victoria, Australia
J Affect Disord 124:256-61. 2010..In addition, the contribution of genetic factors to the pituitary changes in BD remains largely unknown... - Superior temporal gyrus volume in teenagers with first-presentation borderline personality disorderTsutomu Takahashi
Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Melbourne, Australia
Psychiatry Res 182:73-6. 2010..Our preliminary findings might reflect the neurobiological heterogeneity of the disorder... - An MRI study of the superior temporal subregions in first-episode patients with various psychotic disordersTsutomu Takahashi
Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Victoria, Australia
Schizophr Res 113:158-66. 2009..Our findings indicate that morphologic abnormalities of the STG gray matter are specific to schizophrenia among various psychotic disorders, implicating its role in the underlying pathophysiology of schizophrenia... - Relational memory in first episode psychosis: implications for progressive hippocampal dysfunction after illness onsetCali F Bartholomeusz
National Neuroscience Facility, Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne, Carlton South, Victoria, Australia
Aust N Z J Psychiatry 45:206-13. 2011.... - Neuroprotective effects of ethyl-eicosapentaenoic acid in first episode psychosis: a longitudinal T2 relaxometry pilot studyStephen J Wood
Melbourne Neuropsychiatry Centre, University of Melbourne, Australia
Psychiatry Res 182:180-2. 2010..There was an increase in T(2) in the placebo group but not in the E-EPA group, suggesting a neuroprotective effect of E-EPA treatment. In addition, the smaller the increase in T(2), the greater the improvement in negative symptoms... - Insular cortex volume and impulsivity in teenagers with first-presentation borderline personality disorderTsutomu Takahashi
Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Melbourne, Australia
Prog Neuropsychopharmacol Biol Psychiatry 33:1395-400. 2009..Further studies are needed to clarify whether the potential relationship between the insular cortex volume and impulsivity is specific to BPD... - Fractionation of verbal memory impairment in schizophrenia and schizophreniform psychosisStephen J Wood
Melbourne Neuropsychiatry Centre, c National Neuroscience Facility, Carlton, Melbourne, Victoria, Australia
Aust N Z J Psychiatry 41:732-9. 2007..The impact of antipsychotic medications is also unclear. The purpose of the present paper was to investigate verbal memory performance in established schizophrenia (SZ) and first-episode schizophreniform psychosis (FE)... - Surface-based morphometry of the anterior cingulate cortex in first episode schizophreniaAlex Fornito
Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Australia
Hum Brain Mapp 29:478-89. 2008.... - Inhibitory control in young adolescents: the role of sex, intelligence, and temperamentMurat Yucel
The University of Melbourne, Melbourne Health, Melbourne, Victoria, Australia
Neuropsychology 26:347-56. 2012..However, sex differences in inhibitory control are often not expressed experimentally during task performance. Here, we sought to examine how sex, temperament, and intelligence are related to different aspects of inhibitory control... - Anatomical abnormalities of the anterior cingulate and paracingulate cortex in patients with bipolar I disorderAlex Fornito
Melbourne Neuropsychiatry Centre, The University of Melbourne, Melbourne, Australia
Psychiatry Res 162:123-32. 2008..These findings suggest that bipolar disorder is associated with more pronounced changes in the PaC, and that reliance on volumetric measures alone may obscure more subtle differences... - Medial temporal lobe glutathione concentration in first episode psychosis: a 1H-MRS investigationStephen J Wood
Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Australia
Neurobiol Dis 33:354-7. 2009..This study provides further evidence of significant perturbations in brain GSH in first episode psychosis, and supports a broader involvement of GSH in the pathophysiology of schizophrenia... - The effect of atypical antipsychotics on pituitary gland volume in patients with first-episode psychosis: a longitudinal MRI studyJohn Paul Nicolo
Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Australia
Schizophr Res 116:49-54. 2010..Qualifying and quantifying the effect of atypical antipsychotics on the volume of the pituitary gland will determine whether this measure is valid as a future estimate of HPA-axis activation in psychotic populations... 
Anatomical abnormalities of the anterior cingulate cortex in schizophrenia: bridging the gap between neuroimaging and neuropathologyAlex Fornito
Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne, Victoria, Australia
Schizophr Bull 35:973-93. 2009..We discuss the potential mechanisms that might facilitate integration of these findings and consider strategies for future research...- Increased pituitary volume in patients with established bipolar affective disorderTsutomu Takahashi
Department of Psychiatry, Melbourne Neuropsychiatry Centre, University of Melbourne and Melbourne Health, Victoria, Australia
Prog Neuropsychopharmacol Biol Psychiatry 33:1245-9. 2009..psychotic and nonpsychotic). Pituitary volume was larger in females than in males for both groups. These results support previous neuroendocrine findings that implicate HPA axis dysfunction in the core pathophysiological process of BD... - Attentional set-shifting ability in first-episode and established schizophrenia: Relationship to working memoryChristos Pantelis
Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Sunshine Hospital, St Albans, Victoria 3021, Australia
Schizophr Res 112:104-13. 2009..Longitudinal studies assessing these cognitive functions from illness onset or in prepsychotic individuals are required... - Diagnostic specificity of the insular cortex abnormalities in first-episode psychotic disordersTsutomu Takahashi
Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Victoria, Australia
Prog Neuropsychopharmacol Biol Psychiatry 33:651-7. 2009..These findings suggest that the widespread volume reduction of the insular cortex is specific to established schizophrenia, implicating its role in the neurobiology of clinical characteristics associated with schizophrenia... - Evidence for neuronal dysfunction in the anterior cingulate of patients with schizophrenia: a proton magnetic resonance spectroscopy study at 3 TStephen J Wood
Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne, Australia
Schizophr Res 94:328-31. 2007..Anterior cingulate involvement in schizophrenia is likely to be a result of neuronal loss or dysfunction... - Memory impairments identified in people at ultra-high risk for psychosis who later develop first-episode psychosisWarrick J Brewer
ORYGEN Research Centre, Melbourne, Australia
Am J Psychiatry 162:71-8. 2005..While cognitive deficits are frequently reported in psychotic disorders, it is unclear whether these impairments predate the onset of illness and to what extent they are predictive of later transition to psychosis... - Neuroanatomical abnormalities before and after onset of psychosis: a cross-sectional and longitudinal MRI comparisonChristos Pantelis
Cognitive Neuropsychiatry Research and Academic Unit, and Melbourne Neuropsychiatry Centre, Mental Health Programme, Department of Psychiatry, University of Melbourne and Sunshine Hospital, Victoria, Melbourne, Australia
Lancet 361:281-8. 2003..We investigated this issue with MRI to study people with prodromal symptoms who are at ultra high-risk for the development of psychosis... - Insular cortex volume in established bipolar affective disorder: a preliminary MRI studyTsutomu Takahashi
Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, 161 Barry Street, Carlton South, Victoria 3053, Australia
Psychiatry Res 182:187-90. 2010.... - Hippocampal and anterior cingulate morphology in subjects at ultra-high-risk for psychosis: the role of family history of psychotic illnessStephen J Wood
Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne, National Neuroscience Facility, 161 Barry Street, Carlton South VIC 3053, Australia
Schizophr Res 75:295-301. 2005..Some appear to predate the illness and may be genetic in origin, while others are associated with the onset of the disorder... - Midline brain structures in teenagers with first-presentation borderline personality disorderTsutomu Takahashi
Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Melbourne, Australia
Prog Neuropsychopharmacol Biol Psychiatry 33:842-6. 2009..These preliminary findings suggest that ongoing neuroimaging studies should further evaluate a potential involvement of midline brain structures in the pathogenesis of BPD... - Progressive changes in the development toward schizophrenia: studies in subjects at increased symptomatic riskStephen J Wood
Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne, Australia
Schizophr Bull 34:322-9. 2008..Active changes during transition to illness may present the potential to intervene and ameliorate these changes with potential benefit clinically... - Structural abnormalities in the cuneus associated with Herpes Simplex Virus (type 1) infection in people at ultra high risk of developing psychosisThomas J Whitford
Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Carlton South, VIC 3053, Australia
Schizophr Res 135:175-80. 2012.... - Variability of the paracingulate sulcus and morphometry of the medial frontal cortex: associations with cortical thickness, surface area, volume, and sulcal depthAlex Fornito
Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne, Melbourne, Australia
Hum Brain Mapp 29:222-36. 2008.... - Progressive brain structural changes mapped as psychosis develops in 'at risk' individualsDaqiang Sun
Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Parkville, Victoria, Australia
Schizophr Res 108:85-92. 2009..We hypothesized that progressive volume loss occurs in prefrontal regions during the transition to psychosis... - Pituitary volume predicts future transition to psychosis in individuals at ultra-high risk of developing psychosisBelinda Garner
Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne, Royal Melbourne Hospital, Melbourne, Australia
Biol Psychiatry 58:417-23. 2005..032). CONCLUSIONS: The phase before the onset of psychosis is associated with a larger pituitary volume, suggesting activation of the HPA axis... - Abnormal white matter microstructure in schizophrenia: a voxelwise analysis of axial and radial diffusivityMarc L Seal
Melbourne Neuropsychiatry Centre, The University of Melbourne, Victoria, Australia
Schizophr Res 101:106-10. 2008..This finding suggests that the loss of white matter integrity in schizophrenia is the result of demyelination and/or changes to the axonal cytoskeleton rather than gross axonal damage... - Morphology of the paracingulate sulcus and executive cognition in schizophreniaAlex Fornito
Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne, National Neuroscience Facility, Levels 2 and 3, Alan Gilbert Building, 161 Barry St, Carlton South, Victoria 3053, Australia
Schizophr Res 88:192-7. 2006..This suggests that prior reports of impaired performance on such tasks in schizophrenia may be partly explained by the reduced frequency of a leftward PCS asymmetry in this population... - Olfactory sensitivity through the course of psychosis: Relationships to olfactory identification, symptomatology and the schizophrenia odourWarrick J Brewer
ORYGEN Research Centre, Melbourne, Victoria, Australia
Psychiatry Res 149:97-104. 2007..This may be linked to olfactory habituation effects, abnormal chemical processing or a genetic predisposition... - Optimizing hippocampal segmentation in infants utilizing MRI post-acquisition processingDeanne K Thompson
Critical Care and Neurosciences, Murdoch Childrens Research Institute, Royal Children s Hospital, Melbourne, Australia
Neuroinformatics 10:173-80. 2012.... - The impact of cannabis use on cognitive functioning in patients with schizophrenia: a meta-analysis of existing findings and new data in a first-episode sampleMurat Yucel
Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, National Neuroscience Facility, Alan Gilbert Building, 161 Barry Street, Carlton South, Victoria 3053, Australia
Schizophr Bull 38:316-30. 2012.... - Neuroanatomical abnormalities in schizophrenia: a multimodal voxelwise meta-analysis and meta-regression analysisEmre Bora
Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Level 3, National Neuroscience Facility, Alan Gilbert Building, 161, Barry St, Carlton South, Vic, 3053, Australia
Schizophr Res 127:46-57. 2011..However, the available findings are biased towards characteristics of schizophrenia samples with poor prognosis... - Impairment of olfactory identification ability in individuals at ultra-high risk for psychosis who later develop schizophreniaWarrick J Brewer
Department of Psychiatry, University of Melbourne, Melbourne, Australia
Am J Psychiatry 160:1790-4. 2003..Previous investigation has revealed stable olfactory identification deficits in neuroleptic-naive patients experiencing a first episode of psychosis, but it is unknown if these deficits predate illness onset... - Early processing deficits in object working memory in first-episode schizophreniform psychosis and established schizophreniaBirgit Mathes
Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Sunshine Hospital, Melbourne, Australia
Psychol Med 35:1053-62. 2005..CONCLUSIONS: Our results suggest a deficit in patients with psychotic illness in the initial processes necessary to actively maintain information, such as the ability to form an internal representation of complex objects... - A manual and automated MRI study of anterior cingulate and orbito-frontal cortices, and caudate nucleus in obsessive-compulsive disorder: comparison with healthy controls and patients with schizophreniaJem Riffkin
Melbourne Neuropsychiatry Centre, University of Melbourne and Sunshine Hospital, Melbourne, Victoria, Australia
Psychiatry Res 138:99-113. 2005..The findings suggest that in contrast to findings in SCZ, there are very few (if any) gross structural anomalies in OCD... - Hippocampal shape variations at term equivalent age in very preterm infants compared with term controls: perinatal predictors and functional significance at age 7Deanne K Thompson
Murdoch Childrens Research Institute, Royal Children s Hospital, Melbourne, Australia
Neuroimage 70:278-87. 2013..This study provides further insight into early hippocampal development and the nature of hippocampal abnormalities in prematurity... - Markers of vulnerability to obsessive-compulsive disorder in an ultra-high risk sample of patients who developed psychosisLeonardo F Fontenelle
Melbourne Neuropsychiatry Centre, University of Melbourne and Melbourne Health, Carlton South, Australia
Early Interv Psychiatry 6:201-6. 2012..The study aims to identify markers of vulnerability to obsessive-compulsive disorder (OCD) in an ultra-high risk sample of patients who developed psychosis... - Neuroimaging and treatment evidence for clinical staging in psychotic disorders: from the at-risk mental state to chronic schizophreniaStephen J Wood
Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Melbourne, Australia
Biol Psychiatry 70:619-25. 2011..For all three, the balance of evidence supports the predictions of the staging model. However, there are a number of alternative explanations for these findings, including the effects of medication and symptom heterogeneity... - State, trait and biochemical influences on human anterior cingulate functionMurat Yucel
Melbourne Neuropsychiatry Centre, Australia
Neuroimage 34:1766-73. 2007..They also highlight the importance of considering enduring personal characteristics when mapping human brain-behavior relationships... - Increased duration of illness is associated with reduced volume in right medial temporal/anterior cingulate grey matter in patients with chronic schizophreniaDennis Velakoulis
Cognitive Neuropsychiatry Research and Academic Unit, Department of Psychiatry, University of Melbourne and Sunshine Hospital, St Albans, Australia
Schizophr Res 57:43-9. 2002..The inverse correlation between right frontal, temporal and cerebellar volumes and the time since the onset of schizophrenia could reflect progressive tissue loss following the first episode of the disorder... - The influence of sulcal variability on morphometry of the human anterior cingulate and paracingulate cortexAlex Fornito
Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne, Australia
Neuroimage 33:843-54. 2006.... - The localization and lateralization of memory deficits in children with temporal lobe epilepsyLinda M Gonzalez
Australian Centre for Child Neuropsychology Studies, Murdoch Children s Research Institute, Melbourne, Australia
Epilepsia 48:124-32. 2007..Further, differences between mesial and lateral subgroups have not been adequately examined. This study aimed to discern more specific patterns of memory impairment in children with TLE... - A longitudinal study of obsessive-compulsive disorder in individuals at ultra-high risk for psychosisLeonardo F Fontenelle
Melbourne Neuropsychiatry Centre, University of Melbourne and Melbourne Health, Australia
J Psychiatr Res 45:1140-5. 2011.... - Working memory load improves early stages of independent visual processingLuca Cocchi
Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Australia
Neuropsychologia 49:92-102. 2011..More broadly, our findings are in line with theoretical models implicating the engagement of frontal regions in synchronizing and optimizing mnemonic and perceptual resources towards multiple goals... - Diseases of white matter and schizophrenia-like psychosisMark Walterfang
Melbourne Neuropsychiatry Centre, Level 2, John Cade Building, Royal Melbourne Hospital, Melbourne, Victoria 3050, Australia
Aust N Z J Psychiatry 39:746-56. 2005..To analyse the available data regarding the presentation of psychosis in diseases of central nervous system (CNS) white matter... - Brain changes during the onset of schizophrenia: implications for neurodevelopmental theoriesStephen J Wood
Melbourne Neuropsychiatry Centre, University of Melbourne and Melbourne Health, Melbourne, Vic
Med J Aust 190:S10-3. 2009..Although the cause of these changes is unclear, they challenge the conventional neurodevelopmental model of schizophrenia... - Anterior cingulate dysfunction: implications for psychiatric disorders?Murat Yucel
Melbourne Neuropsychiatry Centre Sunshine Hospital, Department of Psychiatry, University of Melbourne, Parkville, Australia
J Psychiatry Neurosci 28:350-4. 2003 - Morphology of the anterior cingulate cortex in young men at ultra-high risk of developing a psychotic illnessMurat Yucel
Department of Psychiatry, University of Melbourne, Parkville, Victoria, Australia
Br J Psychiatry 182:518-24. 2003..The anterior cingulate cortex (ACC) is consistently implicated in the pathophysiology of schizophrenia, and our own work has identified morphological anomalies in the ACC of people with this disorder... - Paracingulate morphologic differences in males with established schizophrenia: a magnetic resonance imaging morphometric studyMurat Yucel
Cognitive Neuropsychiatry Research and Academic Unit, Department of Psychiatry, The University of Melbourne, Sunshine Hospital, Melbourne, Victoria, Australia
Biol Psychiatry 52:15-23. 2002..Given the evidence showing an absence or reversal of normal anatomical asymmetries in patients with schizophrenia, the current study examined the anterior cingulate cortex sulcal-gyral patterns in patients with schizophrenia... - Are neuropsychological impairments in children with early-treated phenylketonuria (PKU) related to white matter abnormalities or elevated phenylalanine levels?Peter J Anderson
Critical Care and Neurosciences, Murdoch Childrens Research Institute, Melbourne, Australia
Dev Neuropsychol 32:645-68. 2007..Our findings also offer some support for dopamine depletion in the prefrontal cortex, however adverse consequences as a result of norepinephrine and serotonin deficiencies should not be discounted... - Neuropsychological functioning in children with early-treated phenylketonuria: impact of white matter abnormalitiesPeter J Anderson
Department of Psychology, Royal Children s Hospital, Melbourne, Victoria, Australia
Dev Med Child Neurol 46:230-8. 2004..However, children with no detectable, or mild WMAs, also displayed cognitive problems, indicating that neuropsychological functioning in children with ETPKU is determined by a complex interaction of biological and environmental factors... - Neuropathological, neurogenetic and neuroimaging evidence for white matter pathology in schizophreniaMark Walterfang
Melbourne Neuropsychiatry Centre, University of Melbourne, Victoria, Australia
Neurosci Biobehav Rev 30:918-48. 2006.... - Neurobiology of schizophrenia spectrum disorders: the role of oxidative stressStephen J Wood
Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Melbourne, Australia
Ann Acad Med Singapore 38:396-6. 2009..We argue that a better understanding of the mechanisms and pathways underlying oxidative stress will assist in developing the therapeutic potential of this area... - Evidence of altered prefrontal-thalamic circuitry in schizophrenia: an optimized diffusion MRI studyStephen E Rose
Centre for Magnetic Resonance, University of Queensland, Brisbane 4072, Australia
Neuroimage 32:16-22. 2006..001). This study has shown for the first time that MD measures offer an alternative strategy for investigating altered prefrontal-thalamic circuitry in schizophrenia... - Generalized and specific cognitive performance in clinical high-risk cohorts: a review highlighting potential vulnerability markers for psychosisWarrick J Brewer
ORYGEN Research Centre and Early Psychosis Prevention and Intervention Centre, EPPIC, Department of Psychiatry, University of Melbourne, Australia
Schizophr Bull 32:538-55. 2006..Delineation of the relationship between specific cognitive ability and symptoms from data-driven approaches may improve our understanding of the role of cognition during psychosis onset... - Neuroanatomical correlates of temperament in early adolescentsSarah Whittle
Department of Psychiatry, University of Melbourne, Victoria 3052, Australia
J Am Acad Child Adolesc Psychiatry 47:682-93. 2008..In the present study, we examined the relation between four core temperament dimensions and anatomically defined regions of the limbic and prefrontal cortices... - Hippocampal and amygdala volumes according to psychosis stage and diagnosis: a magnetic resonance imaging study of chronic schizophrenia, first-episode psychosis, and ultra-high-risk individualsDennis Velakoulis
Melbourne Neuropsychiatry Centre and Department of Psychiatry, University of Melbourne, Australia
Arch Gen Psychiatry 63:139-49. 2006..These studies have been limited by small samples and the absence of patients early in the course of illness... - Anterior cingulate activation during Stroop task performance: a PET to MRI coregistration study of individual patients with schizophreniaMurat Yucel
Cognitive Neuropsychiatry Research and Academic Unit, Department of Psychiatry, Howard Florey Institute, University of Melbourne, Victoria, Australia
Am J Psychiatry 159:251-4. 2002.... - Cognitive decline following psychosis onset: data from the PACE clinicStephen J Wood
Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne, c o National Neuroscience Facility, 161 Barry Street, Carlton South, VIC 3053 Australia
Br J Psychiatry Suppl 51:s52-7. 2007..The origin of cognitive impairments in psychotic disorders is still unclear. Although some deficits are apparent prior to the onset of frank illness, it is unknown if they progress... - The Observer Memory Questionnaire-Parent Form: introducing a new measure of everyday memory for childrenLinda M Gonzalez
Royal Children s Hospital, Department of Psychology, Parkville, Victoria, 3052, Australia
J Int Neuropsychol Soc 14:337-42. 2008..Everyday memory ratings were related to a wider range of neuropsychological measures in this group. Findings are encouraging in terms of the properties of the OMQ-PF and suggest further development of the scale is warranted... - Neonate hippocampal volumes: prematurity, perinatal predictors, and 2-year outcomeDeanne K Thompson
Howard Florey Institute, Centre for Neuroscience, University of Melbourne, Melbourne, Victoria, Australia
Ann Neurol 63:642-51. 2008..To compare preterm (PT) and full-term (FT) infant hippocampal volumes and to investigate the relations among PT hippocampal volume, perinatal risk factors, and neurodevelopmental outcome... - Implications of lipid biology for the pathogenesis of schizophreniaGregor E Berger
Early Psychosis Prevention and Intervention Centre, MH SKY EPPIC, Victoria
Aust N Z J Psychiatry 36:355-66. 2002..Both aspects are proposed as being important in the pathogenesis of schizophrenia. The purpose of this paper is to examine the implications of lipid biology, in particular the role of essential fatty acids (EFA), for schizophrenia... - Ethyl-eicosapentaenoic acid in first-episode psychosis: a randomized, placebo-controlled trialGregor E Berger
ORYGEN Research Centre incorporating the Early Psychosis Prevention and Intervention Centre EPPIC, University of Melbourne, Australia
J Clin Psychiatry 68:1867-75. 2007..To investigate if ethyl-eicosapentaenoic acid (E-EPA) augmentation improves antipsychotic efficacy and tolerability in first-episode psychosis (FEP)... - Thalamic and caudate volumes in monozygotic twins discordantfor schizophreniaNicola Bridle
Cognitive Neuropsychiatry Research and Academic Unit, The University of Melbourne, Parkville, Victoria, Australia
Aust N Z J Psychiatry 36:347-54. 2002..Such interactions need to be considered in future studies investigating brain structural abnormalities in schizophrenia and other disorders... - Structural brain imaging evidence for multiple pathological processes at different stages of brain development in schizophreniaChristos Pantelis
Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne, Royal Melbourne Hospital, Sunshine Hospital, Victoria
Schizophr Bull 31:672-96. 2005.... - Stress, the hippocampus and the hypothalamic-pituitary-adrenal axis: implications for the development of psychotic disordersLisa J Phillips
Department of Psychology, University of Melbourne, Parkville, Victoria, Australia
Aust N Z J Psychiatry 40:725-41. 2006..This paper summarizes and discusses evidence supporting a role for HPA-axis dysfunction in the early phase of schizophrenia and related disorders... - Morphology of the corpus callosum at different stages of schizophrenia: cross-sectional study in first-episode and chronic illnessMark Walterfang
Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne North Western Mental Health Program, Sunshine Hospital, Royal Melbourne Hospital, Melbourne corrected
Br J Psychiatry 192:429-34. 2008..The shape of the corpus callosum may differ in schizophrenia, although no study has compared first-episode with established illness... - Normative data from the CANTAB. I: development of executive function over the lifespanCinzia R De Luca
Sunshine Hospital and Department of Psychiatry, University of Melbourne, Australia
J Clin Exp Neuropsychol 25:242-54. 2003..Declines in performance on all tasks were revealed for the 50-64 year old sample, providing support for the vulnerability of executive skills to normal aging... - Early and late neurodevelopmental disturbances in schizophrenia and their functional consequencesChristos Pantelis
Cognitive Neuropsychiatry Research and Academic Unit, Sunshine Hospital, 176 Furlong Road, St Albans, 3021, Victoria, Australia
Aust N Z J Psychiatry 37:399-406. 2003..In this paper we review the timing of structural changes in schizophrenia and argue that schizophrenia is a neuro-developmental disorder with limited progressive brain changes occurring during the evolution and early phase of psychosis... - Pituitary volume in psychosisCarmine M Pariante
Division of Psychological Medicine, Institute of Psychiatry, King s College London, UK
Br J Psychiatry 185:5-10. 2004..Patients with psychosis have activation of the hypothalamic-pituitary-adrenal (HPA) axis during the acute phase of the psychosis. Whether this has any morphological consequences for the pituitary gland is currently unknown... - The transition to psychosis: risk factors and brain changesStephen J Wood
Epidemiol Psichiatr Soc 13:137-40. 2004 - Sustained attention in young people at high risk of psychosis does not predict transition to psychosisShona M Francey
PACE Clinic, ORYGEN Youth Health, Locked Bag 10, Parkville, 3052, Australia
Schizophr Res 79:127-36. 2005..These results support sustained attention as an indicator of vulnerability to psychosis, but suggest that CPT-IP performance does not help to predict transition to psychosis in an ultra high-risk group... - Neurobiology of early psychosisMatcheri S Keshavan
Department of Psychiatry and Behavioral Neurosciences, Wayne State University, UCH 9B, 4201 St Antoine Boulevard, Detroit, MI, USA
Br J Psychiatry Suppl 48:s8-18. 2005..Neurobiological studies of the early course of psychoses, such as schizophrenia, allow investigation of pathophysiology without the confounds of illness chronicity and treatment... - Patient education and informed consent in head and neck surgeryYvonne Chan
Department of Otolaryngology, Wharton Head and Neck Centre, Princess Margaret Hospital, University Health Network, Toronto, Ontario, Canada
Arch Otolaryngol Head Neck Surg 128:1269-74. 2002..Patients' ability to recall potential risks was significantly increased by an educational intervention; all patients would benefit from this intervention...