J P Walsh

Summary

Affiliation: Western Australia
Country: Australia

Publications

  1. ncbi request reprint Dissatisfaction with thyroxine therapy - could the patients be right?
    John P Walsh
    Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, WA 6009, Nedlands, Australia
    Curr Opin Pharmacol 2:717-22. 2002
  2. ncbi request reprint Subclinical thyroid dysfunction and blood pressure: a community-based study
    John P Walsh
    Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Perth, Western Australia, Australia
    Clin Endocrinol (Oxf) 65:486-91. 2006
  3. doi request reprint The relationship between TSH and free T4 in a large population is complex and nonlinear and differs by age and sex
    Narelle C Hadlow
    Department of Clinical Biochemistry, PathWest Laboratory Medicine, Queen Elizabeth II Medical Centre, Nedlands, Western Australia 6009, Australia
    J Clin Endocrinol Metab 98:2936-43. 2013
  4. doi request reprint Plasma calcium as a predictor of cardiovascular disease in a community-based cohort
    John P Walsh
    Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Nedlands, WA, Australia School of Medicine and Pharmacology, The University of Western Australia, Crawley, WA, Australia
    Clin Endocrinol (Oxf) 78:852-7. 2013
  5. doi request reprint Age-related changes in thyroid function: a longitudinal study of a community-based cohort
    Alexandra P Bremner
    School of Population Health, The University of Western Australia, Nedlands, Western Australia 6009, Australia
    J Clin Endocrinol Metab 97:1554-62. 2012
  6. ncbi request reprint Subclinical thyroid dysfunction as a risk factor for cardiovascular disease
    John P Walsh
    Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia
    Arch Intern Med 165:2467-72. 2005
  7. doi request reprint The clinical presentation of autoimmune thyroid disease in men is associated with IL12B genotype
    John P Walsh
    Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Nedlands, WA 6009, Australia
    Clin Endocrinol (Oxf) 74:508-12. 2011
  8. ncbi request reprint Parity and the risk of autoimmune thyroid disease: a community-based study
    John P Walsh
    Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Nedlands, Western Australia 6009, Australia
    J Clin Endocrinol Metab 90:5309-12. 2005
  9. ncbi request reprint Differences between endocrinologists and endocrine surgeons in management of the solitary thyroid nodule
    John P Walsh
    Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia
    Clin Endocrinol (Oxf) 66:844-53. 2007
  10. ncbi request reprint Thyroid dysfunction and serum lipids: a community-based study
    John P Walsh
    Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Perth, Western Australia, Australia
    Clin Endocrinol (Oxf) 63:670-5. 2005

Collaborators

Detail Information

Publications41

  1. ncbi request reprint Dissatisfaction with thyroxine therapy - could the patients be right?
    John P Walsh
    Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, WA 6009, Nedlands, Australia
    Curr Opin Pharmacol 2:717-22. 2002
    ..There are conflicting data on whether combined thyroxine/triiodothyronine treatment is preferable to thyroxine alone in dissatisfied patients...
  2. ncbi request reprint Subclinical thyroid dysfunction and blood pressure: a community-based study
    John P Walsh
    Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Perth, Western Australia, Australia
    Clin Endocrinol (Oxf) 65:486-91. 2006
    ..Overt hypothyroidism and hyperthyroidism are associated with hypertension, but it is uncertain whether the same is true of subclinical hypothyroidism and hyperthyroidism...
  3. doi request reprint The relationship between TSH and free T4 in a large population is complex and nonlinear and differs by age and sex
    Narelle C Hadlow
    Department of Clinical Biochemistry, PathWest Laboratory Medicine, Queen Elizabeth II Medical Centre, Nedlands, Western Australia 6009, Australia
    J Clin Endocrinol Metab 98:2936-43. 2013
    ..The relationship between TSH and T4 is thought to be inverse log-linear, but recent studies have challenged this. There are limited data regarding age and sex differences in the TSH-T4 relationship...
  4. doi request reprint Plasma calcium as a predictor of cardiovascular disease in a community-based cohort
    John P Walsh
    Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Nedlands, WA, Australia School of Medicine and Pharmacology, The University of Western Australia, Crawley, WA, Australia
    Clin Endocrinol (Oxf) 78:852-7. 2013
    ..Using a Cox proportional hazards model, we examined albumin-corrected calcium as a predictor of total mortality, cardiovascular mortality and cardiovascular events up to the end of 2010...
  5. doi request reprint Age-related changes in thyroid function: a longitudinal study of a community-based cohort
    Alexandra P Bremner
    School of Population Health, The University of Western Australia, Nedlands, Western Australia 6009, Australia
    J Clin Endocrinol Metab 97:1554-62. 2012
    ..In cross-sectional studies, serum TSH concentrations increase with age. This has not been examined longitudinally, and it is uncertain whether the TSH increase reflects healthy aging or occult thyroid failure...
  6. ncbi request reprint Subclinical thyroid dysfunction as a risk factor for cardiovascular disease
    John P Walsh
    Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia
    Arch Intern Med 165:2467-72. 2005
    ..There have been few large epidemiological studies examining the association between thyroid dysfunction and cardiovascular disease. In particular, it is uncertain if subclinical hypothyroidism is a risk factor for cardiovascular disease...
  7. doi request reprint The clinical presentation of autoimmune thyroid disease in men is associated with IL12B genotype
    John P Walsh
    Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Nedlands, WA 6009, Australia
    Clin Endocrinol (Oxf) 74:508-12. 2011
    ..As Hashimoto's disease and Graves' disease are thought to arise from mainly Th1 and Th2 immune responses respectively, we hypothesized that IL12B genotype may influence the clinical presentation of autoimmune thyroid disease...
  8. ncbi request reprint Parity and the risk of autoimmune thyroid disease: a community-based study
    John P Walsh
    Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Nedlands, Western Australia 6009, Australia
    J Clin Endocrinol Metab 90:5309-12. 2005
    ..If that is true, then parity should be a risk factor for autoimmune thyroid disease...
  9. ncbi request reprint Differences between endocrinologists and endocrine surgeons in management of the solitary thyroid nodule
    John P Walsh
    Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia
    Clin Endocrinol (Oxf) 66:844-53. 2007
    ..It is not known whether management of the solitary thyroid nodule differs between endocrinologists and endocrine surgeons...
  10. ncbi request reprint Thyroid dysfunction and serum lipids: a community-based study
    John P Walsh
    Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Perth, Western Australia, Australia
    Clin Endocrinol (Oxf) 63:670-5. 2005
    ..It is uncertain whether subclinical hypothyroidism (SCH) is associated with hypercholesterolaemia, particularly in subjects with SCH and serum TSH < or = 10 mU/l. Design,..
  11. doi request reprint Thyrotropin and thyroid antibodies as predictors of hypothyroidism: a 13-year, longitudinal study of a community-based cohort using current immunoassay techniques
    John P Walsh
    Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Nedlands, Western Australia 6009
    J Clin Endocrinol Metab 95:1095-104. 2010
    ..0 mU/liter, and 85.7% (74.1-97.3%) for TSH above 4.0 mU/liter. Conclusions: The use of TSH cutoffs of 2.5 and 4.0 mU/liter, combined with thyroid antibodies, provides a clinically useful estimate of the long-term risk of hypothyroidism...
  12. ncbi request reprint Small changes in thyroxine dosage do not produce measurable changes in hypothyroid symptoms, well-being, or quality of life: results of a double-blind, randomized clinical trial
    John P Walsh
    Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Nedlands, Western Australia
    J Clin Endocrinol Metab 91:2624-30. 2006
    ..This has not been tested in a clinical trial...
  13. ncbi request reprint Paget's disease of bone
    John P Walsh
    Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Nedlands, WA 6009, Australia
    Med J Aust 181:262-5. 2004
    ..A strong case be made for also treating asymptomatic patients with involvement of long bones, vertebrae or base of skull, patients with significant osteolytic lesions, and perhaps all younger patients...
  14. ncbi request reprint A randomized clinical trial comparing oral alendronate and intravenous pamidronate for the treatment of Paget's disease of bone
    J P Walsh
    Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Nedlands, WA 6009, Australia
    Bone 34:747-54. 2004
    ..In patients previously treated with pamidronate, alendronate is more effective...
  15. ncbi request reprint Combined thyroxine/liothyronine treatment does not improve well-being, quality of life, or cognitive function compared to thyroxine alone: a randomized controlled trial in patients with primary hypothyroidism
    John P Walsh
    Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia
    J Clin Endocrinol Metab 88:4543-50. 2003
    ..We conclude that in the doses used in this study, combined T(4)/T(3) treatment does not improve well-being, cognitive function, or quality of life compared with T(4) alone...
  16. doi request reprint Treatment of Paget's disease of bone: a survey of clinical practice in Australia
    J P Walsh
    Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Nedlands, WA 6009, Australia
    Bone 42:1219-25. 2008
    ..Only a minority of courses of oral bisphosphonate treatment are at the recommended dosage and duration, and there is a lack of consensus on regimens for intravenous treatment...
  17. ncbi request reprint What is the optimal treatment for hypothyroidism?
    J P Walsh
    Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Perth, WA
    Med J Aust 174:141-3. 2001
    ..Further research is needed to determine why some patients appear to have a suboptimal response to thyroxine, and whether combined thyroxine/T3 treatment is preferable to thyroxine alone in these patients...
  18. ncbi request reprint Management of Graves' disease in Australia
    J P Walsh
    Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Perth, WA, USA
    Aust N Z J Med 30:559-66. 2000
    ..Surveys of physicians in Europe, the USA and elsewhere have shown marked international differences in the management of Graves' disease. There are no comparable data on clinical practice in Australia...
  19. doi request reprint Postpartum thyroid dysfunction and the long-term risk of hypothyroidism: results from a 12-year follow-up study of women with and without postpartum thyroid dysfunction
    B G A Stuckey
    Keogh Institute for Medical Research, Sir Charles Gairdner Hospital, Nedlands, WA, USA
    Clin Endocrinol (Oxf) 73:389-95. 2010
    ..The long-term risk of hypothyroidism following postpartum thyroid dysfunction (PPTD) is uncertain. Most previous studies have been small, short-term or have lacked a control group...
  20. doi request reprint Low urinary iodine postpartum is associated with hypothyroid postpartum thyroid dysfunction and predicts long-term hypothyroidism
    B G A Stuckey
    Keogh Institute for Medical Research, Nedlands, Western Australia, Australia
    Clin Endocrinol (Oxf) 74:631-5. 2011
    ..Iodine has a major effect on thyroid function. Western Australia has previously been shown to be iodine replete...
  21. ncbi request reprint Assessment of thyroid function during pregnancy: first-trimester (weeks 9-13) reference intervals derived from Western Australian women
    Rhonda M Gilbert
    Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, and School of Medicine and Pharmacology, University of Western Australia, Perth, WA, Australia
    Med J Aust 189:250-3. 2008
    ..To establish first-trimester-specific reference intervals for thyroid function tests in pregnant Australian women...
  22. ncbi request reprint Heritability of serum TSH, free T4 and free T3 concentrations: a study of a large UK twin cohort
    V Panicker
    Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia
    Clin Endocrinol (Oxf) 68:652-9. 2008
    ..Thyroid hormone action influences many metabolic and synthetic processes, but the degree of regulation attributed to genes and environmental factors affecting normal variation remains controversial...
  23. ncbi request reprint Investigations of thyroid hormones and antibodies based on a community health survey: the Busselton thyroid study
    Peter C O'Leary
    Clinical Biochemistry, Women s and Children s Health Service, Princess Margaret Hospital, Subiaco Western Australia, Australia
    Clin Endocrinol (Oxf) 64:97-104. 2006
    ....
  24. doi request reprint Genetic loci linked to pituitary-thyroid axis set points: a genome-wide scan of a large twin cohort
    Vijay Panicker
    Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia 6009
    J Clin Endocrinol Metab 93:3519-23. 2008
    ..The aim of this study was to identify genetic loci associated with these parameters...
  25. doi request reprint Significant inverse relationship between serum free T4 concentration and body mass index in euthyroid subjects: differences between smokers and nonsmokers
    Ashley E Makepeace
    Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia
    Clin Endocrinol (Oxf) 69:648-52. 2008
    ..The objective of this study was to examine the relationships between thyroid function, BMI and smoking in euthyroid subjects...
  26. ncbi request reprint Differences between endocrine surgeons and endocrinologists in the management of non-toxic multinodular goitre
    M C Bhagat
    Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Nedlands, Western Australia 6009, Australia
    Br J Surg 90:1103-12. 2003
    ..It is not known whether the management of multinodular goitre differs between endocrinologists and endocrine surgeons...
  27. doi request reprint Sequestosome 1 mutations in Paget's disease of bone in Australia: prevalence, genotype/phenotype correlation, and a novel non-UBA domain mutation (P364S) associated with increased NF-kappaB signaling without loss of ubiquitin binding
    Sarah L Rea
    Laboratory for Molecular Endocrinology, Western Australian Institute for Medical Research and UWA Centre for Medical Research, University of Western Australia, Nedlands, Australia
    J Bone Miner Res 24:1216-23. 2009
    ..This suggests that increased NF-kappaB signaling, but not the impairment of ubiquitin binding, may be essential in the pathogenesis of PDB associated with SQSTM1 mutations...
  28. ncbi request reprint Erectile dysfunction predicts generalised cardiovascular disease: evidence from a case-control study
    Bronwyn G A Stuckey
    Keogh Institute for Medical Research, Nedlands, WA, Australia
    Atherosclerosis 194:458-64. 2007
    ..To determine whether idiopathic erectile dysfunction, in the absence of overt cardiovascular disease or cardiovascular risk factors, is associated with vascular or autonomic dysfunction...
  29. pmc Pharmacokinetics and pharmacodynamics of gliclazide in Caucasians and Australian Aborigines with type 2 diabetes
    T M Davis
    University of Western Australia, Department of Medicine, Fremantle Hospital, Fremantle, Western Australia, Australia
    Br J Clin Pharmacol 49:223-30. 2000
    ..Gliclazide pharmacokinetics and pharmacodynamics were assessed in 9 Caucasians and 10 Australian Aborigines with uncomplicated type 2 diabetes...
  30. pmc A locus on chromosome 1p36 is associated with thyrotropin and thyroid function as identified by genome-wide association study
    Vijay Panicker
    Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Nedlands, Western Australia
    Am J Hum Genet 87:430-5. 2010
    ..These results advance understanding of the genetic basis of pituitary-thyroid axis function and metabolic regulation...
  31. ncbi request reprint Polycystic ovarian syndrome: marked differences between endocrinologists and gynaecologists in diagnosis and management
    Andrea J Cussons
    Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia
    Clin Endocrinol (Oxf) 62:289-95. 2005
    ..Women with polycystic ovarian syndrome (PCOS) commonly consult endocrinologists or gynaecologists and it is not known whether these specialty groups differ in their approach to management...
  32. ncbi request reprint Urine free cortisol analysis by automated immunoassay and high-performance liquid chromatography for the investigation of Cushing's syndrome
    Simon Y L Ching
    Clinical Biochemistry Department, PathWest Laboratory Medicine, Queen Elizabeth II Medical Centre, Nedlands, Western Australia
    Ann Clin Biochem 43:402-7. 2006
    ..We compared a widely used immunoassay method for urine free corticoids with a high-performance liquid chromatography (HPLC) method for the investigation of Cushing's syndrome...
  33. ncbi request reprint Are Australian children iodine deficient? Results of the Australian National Iodine Nutrition Study
    Mu Li
    School of Public Health, University of Sydney, Edward Ford Building A27, Sydney, NSW 2006, Australia
    Med J Aust 184:165-9. 2006
    ..To document the population iodine nutritional status in Australian schoolchildren...
  34. ncbi request reprint Reproductive toxicology profile of emtricitabine in mice and rabbits
    George M Szczech
    Triangle Pharmaceuticals, Inc, 4611 University Drive, PO Box 50530, Durham, NC 27717, USA
    Reprod Toxicol 17:95-108. 2003
    ..The development and fertility of F(1) progeny were unaffected by emtricitabine in a mouse pre- and post-natal study. These data demonstrate a favorable pre-clinical reproductive safety profile for emtricitabine...
  35. ncbi request reprint Novel UBA domain mutations of SQSTM1 in Paget's disease of bone: genotype phenotype correlation, functional analysis, and structural consequences
    Lynne J Hocking
    Department of Medicine and Therapeutics, University of Aberdeen, Aberdeen, United Kingdom
    J Bone Miner Res 19:1122-7. 2004
    ..Functional and structural analysis showed that disease severity was related to the type of mutation but was unrelated to the polyubiquitin-binding properties of the mutant UBA domain peptides...
  36. ncbi request reprint Ubiquitin-associated domain mutations of SQSTM1 in Paget's disease of bone: evidence for a founder effect in patients of British descent
    Gavin J A Lucas
    Department of Medicine and Therapeutics, University of Aberdeen, Aberdeen, United Kingdom
    J Bone Miner Res 20:227-31. 2005
    ..Here we show that the most common disease-causing mutation (P392L) is carried on a shared haplotype, consistent with a founder effect and a common ancestral origin...
  37. ncbi request reprint A novel mutation (K378X) in the sequestosome 1 gene associated with increased NF-kappaB signaling and Paget's disease of bone with a severe phenotype
    Sarah L Rea
    Laboratory for Molecular Endocrinology, Western Australian Institute for Medical Research, University of Western Australia, Nedlands
    J Bone Miner Res 21:1136-45. 2006
    ..p62 mutants increased NF-kappaB activation and significantly potentiated osteoclast formation and bone resorption in human primary cell cultures...
  38. ncbi request reprint Evaluation of the role of Valosin-containing protein in the pathogenesis of familial and sporadic Paget's disease of bone
    Gavin J A Lucas
    Department of Medicine and Therapeutics, University of Aberdeen, UK
    Bone 38:280-5. 2006
    ..Genetic variation in VCP does not appear to be a common cause of familial or sporadic PDB in the absence of myopathy and dementia...
  39. ncbi request reprint Novel mutations in the calcium-sensing receptor gene associated with biochemical and functional differences in familial hypocalciuric hypercalcaemia
    Bryan K Ward
    Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia
    Clin Endocrinol (Oxf) 64:580-7. 2006
    ..Biochemical data from patients heterozygous for each type of mutant were correlated with functionality...
  40. pmc Regulation of the GABA cell phenotype in hippocampus of schizophrenics and bipolars
    Francine M Benes
    Program in Structural and Molecular Neuroscience, McLean Hospital, Belmont, MA 02178, USA
    Proc Natl Acad Sci U S A 104:10164-9. 2007
    ..In BD, however, a suppression of transcription factors involved in cell differentiation may contribute to GABA dysfunction...
  41. ncbi request reprint Identification of a major locus for Paget's disease on chromosome 10p13 in families of British descent
    Gavin Ja Lucas
    Rheumatic Diseases Unit, University of Edinburgh, Edinburgh, United Kingdom
    J Bone Miner Res 23:58-63. 2008
    ..A major susceptibility locus for PDB was identified on chromosome 10p13 by a genome-wide linkage scan in families of British descent, which accounted for the vast majority of cases not caused by SQSTM1 mutations...