Colin J R Stewart

..To describe the pathological and immunohistochemical features of five cases of superficial cervico-vaginal myofibroblastoma (SCVM), a recently described mesenchymal tumour affecting middle-aged and elderly females...

..The simple algorithm proposed by Seidman and colleagues for assessment of ovarian mucinous tumors is helpful and can be applied to low-grade adenocarcinomas of other histological types...

..Review of the frozen-section slides from the CCC with discrepant intraoperative diagnoses showed features suggestive or indicative of the correct diagnosis in 7 (39%) of 18 cases...

..To investigate micro-anatomical variations in proliferative activity within uterine endometrioid adenocarcinoma with particular emphasis on tumour areas comprising microcystic, elongated and fragmented ('MELF') glands...

..To assess the immunophenotypic changes associated with epithelial-mesenchymal transition (EMT) in endocervical adenocarcinoma, and correlate the findings with tumour morphology including growth pattern...

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..This study confirms that ovarian frozen section is a generally reliable technique, but there are problematic areas, particularly involving the assessment of borderline tumors...

..In this study fascin expression was assessed in adenocarcinoma in situ (ACIS) and invasive adenocarcinoma of the endocervix, and the results were correlated with tumour growth patterns (papillary, glandular or infiltrative)...

..Therefore, data derived from the analysis of primary GCT may not always be applicable to recurrent tumors. These findings may have implications for management including the potential response of GCT to adjuvant therapies...

..In this study the accuracy of intraoperative cytology has been assessed and the results compared with frozen section diagnosis...

..Further studies are required to determine the mechanism and biologic significance of localized alterations in CK19 expression within endometrial neoplasms...

..Careful histopathologic examination may be required to identify small, radiologically occult teratomas, and to demonstrate the presence of subtle neoplastic neuroglial components in teratomas associated with anti-NMDAR encephalitis...

..To determine the frequency and distribution of Fallopian tube involvement in patients with ovarian metastases of non-gynaecological origin...

..In this report two further examples of this rare tumour are described, and the immunohistological phenotype including expression of MUC proteins is compared with secondary ovarian involvement by low-grade appendiceal mucinous neoplasm...

..Therefore, fascin immunoreactivity was investigated in a series of endometrial carcinomas specifically comparing expression in conventional tumour areas, foci of MELF-type invasion and in stromal elements...

..As MELF pattern invasion is associated with the loss of galectin-3 expression, there may be implications for the use of galectin inhibitors in the treatment of endometrial carcinomas and other malignancies...

..This feature has not been recorded previously in tubulo-squamous polyp and potentially could create diagnostic difficulty with other lesions such as basal cell/adenoid basal carcinoma or small-cell neuroendocrine carcinoma...

..These changes share features of epithelial-mesenchymal transition (EMT) in carcinomas arising at other sites. The aim was to compare the immunophenotypic profile of MELF-type epithelium with conventional glandular areas of EEC...

..Epithelial-mesenchymal transition (EMT) may be a mechanism of invasion in cervical neoplasia and expression of EMT-associated proteins could prove useful in this diagnostic setting...

..To study E-cadherin and β-catenin expression in stage I adult-type granulosa cell tumours (AGCTs) and correlate the findings with tumour morphology and clinical outcome...

..Diagnostic histopathologists are ideally placed to critically evaluate the role of EMT in gynaecological and other types of malignancy...

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..To determine the frequency of endocrine cell micronests (ECM) and single endocrine cells (SEC) within the glandular mucosa of the distal oesophagus and oesophagogastric junction (OGJ) following neo-adjuvant therapy for adenocarcinoma...

..We have noted that these stromal changes may be highlighted by a simple reticulin stain; therefore, we have evaluated reticulin staining in a series of endometrial biopsy specimens from patients with intra-uterine and ectopic gestations...

..In this report 2 cases of extrauterine adenomyoma are presented in which the smooth muscle component showed focal atypical (symplastic) cytologic appearances...