David R Hillman

Summary

Affiliation: Western Australia
Country: Australia

Publications

  1. ncbi request reprint Public health implications of sleep loss: the community burden
    David R Hillman
    Department of Pulmonary Physiology and Sleep Medicine, Sir Charles Gairdner Hospital, Perth, WA, Australia
    Med J Aust 199:S7-10. 2013
  2. doi request reprint The effect of diaphragm contraction on upper airway collapsibility
    David R Hillman
    West Australian Sleep Disorders Research Institute, Department of Pulmonary Physiology and Sleep Medicine, Sir Charles Gairdner Hospital, Perth, Australia
    J Appl Physiol (1985) 115:337-45. 2013
  3. doi request reprint Anesthesia, sleep, and upper airway collapsibility
    David R Hillman
    West Australian Sleep Disorders Research Institute, Department of Pulmonary Physiology, Sir Charles Gairdner Hospital, Nedlands, Perth, Australia
    Anesthesiol Clin 28:443-55. 2010
  4. doi request reprint Evolution of changes in upper airway collapsibility during slow induction of anesthesia with propofol
    David R Hillman
    West Australian Sleep Disorders Research Institute, and Department of Pulmonary Physiology, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia 6009
    Anesthesiology 111:63-71. 2009
  5. pmc Effect of body posture on pharyngeal shape and size in adults with and without obstructive sleep apnea
    Jennifer H Walsh
    West Australian Sleep Disorders Research Institute, Sir Charles Gairdner Hospital, Nedlands, Western Australia
    Sleep 31:1543-9. 2008
  6. pmc Influence of head extension, flexion, and rotation on collapsibility of the passive upper airway
    Jennifer H Walsh
    West Australian Sleep Disorders Research Institute, Department of Pulmonary Physiology, Sir Charles Gairdner Hospital, Nedlands, WA, Australia
    Sleep 31:1440-7. 2008
  7. doi request reprint Gastro-oesophageal reflux symptoms are related to the presence and severity of obstructive sleep apnoea
    Kelly L Shepherd
    Department of Pulmonary Physiology, West Australian Sleep Disorders Research Institute, Sir Charles Gairdner Hospital, Nedlands, Australia
    J Sleep Res 20:241-9. 2011
  8. doi request reprint Evaluation of pharyngeal shape and size using anatomical optical coherence tomography in individuals with and without obstructive sleep apnoea
    Jennifer H Walsh
    West Australian Sleep Disorders Research Institute, Sir Charles Gairdner Hospital, Perth, Western Australia, Australia
    J Sleep Res 17:230-8. 2008
  9. ncbi request reprint Feasibility of Applying Real-time Optical Imaging During Bronchoscopic Interventions for Central Airway Obstruction
    Jonathan P Williamson
    Departments of Pulmonary Physiology Respiratory Medicine Radiology, Sir Charles Gairdner Hospital School of Anatomy and Human Biology Optical Biomedical Engineering Laboratory, School of Electrical, Electronic and Computer Engineering, The University of Western Australia West Australian Sleep Disorders Research Institute, Perth, Australia
    J Bronchology Interv Pulmonol 17:307-16. 2010
  10. doi request reprint Variability of human upper airway collapsibility during sleep and the influence of body posture and sleep stage
    Jeremy S L Ong
    Centre for Sleep Science, School of Anatomy and Human Biology, University of Western Australia, Australia
    J Sleep Res 20:533-7. 2011

Detail Information

Publications35

  1. ncbi request reprint Public health implications of sleep loss: the community burden
    David R Hillman
    Department of Pulmonary Physiology and Sleep Medicine, Sir Charles Gairdner Hospital, Perth, WA, Australia
    Med J Aust 199:S7-10. 2013
    ....
  2. doi request reprint The effect of diaphragm contraction on upper airway collapsibility
    David R Hillman
    West Australian Sleep Disorders Research Institute, Department of Pulmonary Physiology and Sleep Medicine, Sir Charles Gairdner Hospital, Perth, Australia
    J Appl Physiol (1985) 115:337-45. 2013
    ..The effect appears primarily mediated by changes in lung volume rather than mediastinal traction from diaphragm descent. The study provides a rationale for use of continuous phrenic stimulation to treat obstructive sleep apnea. ..
  3. doi request reprint Anesthesia, sleep, and upper airway collapsibility
    David R Hillman
    West Australian Sleep Disorders Research Institute, Department of Pulmonary Physiology, Sir Charles Gairdner Hospital, Nedlands, Perth, Australia
    Anesthesiol Clin 28:443-55. 2010
    ..Specific follow-up of suspected cases is needed to ensure that the sleep-related component of the problem receives appropriate care...
  4. doi request reprint Evolution of changes in upper airway collapsibility during slow induction of anesthesia with propofol
    David R Hillman
    West Australian Sleep Disorders Research Institute, and Department of Pulmonary Physiology, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia 6009
    Anesthesiology 111:63-71. 2009
    ..This study assessed how this increase in collapsibility evolves during slow Propofol induction and how it relates to anesthesia-induced changes in upper airway muscle activity and conscious state...
  5. pmc Effect of body posture on pharyngeal shape and size in adults with and without obstructive sleep apnea
    Jennifer H Walsh
    West Australian Sleep Disorders Research Institute, Sir Charles Gairdner Hospital, Nedlands, Western Australia
    Sleep 31:1543-9. 2008
    ..This study compared the effect of body posture on upper airway shape and size in individuals with OSA with control subjects matched for age, BMI, and gender...
  6. pmc Influence of head extension, flexion, and rotation on collapsibility of the passive upper airway
    Jennifer H Walsh
    West Australian Sleep Disorders Research Institute, Department of Pulmonary Physiology, Sir Charles Gairdner Hospital, Nedlands, WA, Australia
    Sleep 31:1440-7. 2008
    ..To determine the effect of head posture on upper airway collapsibility and site of collapse of the passive human upper airway...
  7. doi request reprint Gastro-oesophageal reflux symptoms are related to the presence and severity of obstructive sleep apnoea
    Kelly L Shepherd
    Department of Pulmonary Physiology, West Australian Sleep Disorders Research Institute, Sir Charles Gairdner Hospital, Nedlands, Australia
    J Sleep Res 20:241-9. 2011
    ..This association is independent of other risk factors including age, gender and body mass index, suggesting a causal relationship between OSA and nocturnal reflux...
  8. doi request reprint Evaluation of pharyngeal shape and size using anatomical optical coherence tomography in individuals with and without obstructive sleep apnoea
    Jennifer H Walsh
    West Australian Sleep Disorders Research Institute, Sir Charles Gairdner Hospital, Perth, Western Australia, Australia
    J Sleep Res 17:230-8. 2008
    ..These findings suggest that it is an abnormality in size rather than shape that is the more important anatomical predictor of OSA...
  9. ncbi request reprint Feasibility of Applying Real-time Optical Imaging During Bronchoscopic Interventions for Central Airway Obstruction
    Jonathan P Williamson
    Departments of Pulmonary Physiology Respiratory Medicine Radiology, Sir Charles Gairdner Hospital School of Anatomy and Human Biology Optical Biomedical Engineering Laboratory, School of Electrical, Electronic and Computer Engineering, The University of Western Australia West Australian Sleep Disorders Research Institute, Perth, Australia
    J Bronchology Interv Pulmonol 17:307-16. 2010
    ..This study aims to describe the potential role of real-time aOCT in guiding interventions during CAO procedures...
  10. doi request reprint Variability of human upper airway collapsibility during sleep and the influence of body posture and sleep stage
    Jeremy S L Ong
    Centre for Sleep Science, School of Anatomy and Human Biology, University of Western Australia, Australia
    J Sleep Res 20:533-7. 2011
    ..When within-subject variability is accounted for, change in body posture from supine to lateral significantly decreases passive pharyngeal collapsibility...
  11. ncbi request reprint Modulation of upper and lower esophageal sphincter tone during sleep
    Peter R Eastwood
    Department of Pulmonary Physiology, Sir Charles Gairdner Hospital, Hospital Avenue, Nedlands, WA 6009, Australia
    Sleep Med 8:135-43. 2007
    ..This study sought to describe the effects of sleep, respiration and posture on the function of the UES and the LES and the pressure differentials developed across them...
  12. ncbi request reprint Collapsibility of the upper airway at different concentrations of propofol anesthesia
    Peter R Eastwood
    West Australian Sleep Disorders Research Institute, Department of Pulmonary Physiology, Sir Charles Gairdner Hospital, and School of Anatomy and Human Biology, University of Western Australia
    Anesthesiology 103:470-7. 2005
    ..This study investigated the effect of varying concentrations of propofol on upper airway collapsibility and the mechanisms responsible for it...
  13. doi request reprint Estimating maximum work rate during incremental cycle ergometry testing from six-minute walk distance in patients with chronic obstructive pulmonary disease
    Kylie Hill
    Department of Pulmonary Physiology, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia
    Arch Phys Med Rehabil 89:1782-7. 2008
    ....
  14. doi request reprint Vital capacity and oxygen saturation at rest and after exercise predict hypoxaemia during hypoxic inhalation test in patients with respiratory disease
    Ivan T Ling
    Department of Pulmonary Physiology and Sleep Medicine, Sir Charles Gairdner Hospital, Perth, Western Australia, Australia
    Respirology 18:507-13. 2013
    ..We assessed whether oxygen saturation (SpO2) during HIT can be predicted by simple measures of lung function and exercise-induced hypoxaemia...
  15. pmc Excessive daytime sleepiness increases the risk of motor vehicle crash in obstructive sleep apnea
    Kim L Ward
    Centre for Genetic Origins of Health and Disease, The University of Western Australia, Perth, Australia Western Australian Sleep Disorders Research Institute, Queen Elizabeth II Medical Centre, Perth, Australia
    J Clin Sleep Med 9:1013-21. 2013
    ..1) To describe the incidence rate of motor vehicle crashes (MVCs) in patients with obstructive sleep apnea (OSA); and (2) to investigate MVC risk factors in OSA patients...
  16. ncbi request reprint Anaerobic metabolism of inspiratory muscles in COPD
    Peter R Eastwood
    Department of Pulmonary Physiology, Sir Charles Gairdner Hospital, Perth, Western Australia, Australia
    Respirology 11:32-40. 2006
    ....
  17. ncbi request reprint Relationship between upper airway and inspiratory pump muscle force in obstructive sleep apnea
    Kelly L Shepherd
    West Australian Sleep Disorders Research Institute, Department of Pulmonary Physiology, Sir Charles Gairdner Hospital, Nedlands, Western Australia 6009, Australia
    Chest 130:1757-64. 2006
    ..It is possible that the relative strengths of UA dilator and inspiratory pump muscles could be an important determinant of the susceptibility to UA collapse during sleep (ie, obstructive sleep apnea [OSA])...
  18. doi request reprint Obstructive sleep apnoea and nocturnal gastroesophageal reflux are common in lung transplant patients
    Kelly L Shepherd
    Department of Pulmonary Physiology, West Australian Sleep Disorders Research Institute, Sir Charles Gairdner Hospital, Nedlands, WA, Australia
    Respirology 13:1045-52. 2008
    ..This study investigated the relationship between nocturnal GOR, OSA and BOS in a group of lung transplant patients...
  19. ncbi request reprint Collapsibility of the upper airway during anesthesia with isoflurane
    Peter R Eastwood
    West Australian Sleep Disorders Research Institute, Department of Pulmonary Physiology, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia
    Anesthesiology 97:786-93. 2002
    ..The unprotected upper airway tends to obstruct during general anesthesia, yet its mechanical properties have not been studied in detail during this condition...
  20. pmc Sex differences in the association of regional fat distribution with the severity of obstructive sleep apnea
    Laila Simpson
    Centre for Genetic Epidemiology and Biostatistics, University of Western Australia, Perth, Australia
    Sleep 33:467-74. 2010
    ....
  21. doi request reprint High prevalence of undiagnosed obstructive sleep apnoea in the general population and methods for screening for representative controls
    Laila Simpson
    Centre for Genetic Epidemiology and Biostatistics, University of Western Australia, 14 16 Parkway, Crawley, Perth, 6009 WA, Australia
    Sleep Breath 17:967-73. 2013
    ..This study aims to estimate undiagnosed moderate to severe OSA in a general population sample and to determine the capacity of questions from the Berlin questionnaire (BQ) to identify subjects without diagnosed OSA of this severity...
  22. pmc Distribution of airway narrowing responses across generations and at branching points, assessed in vitro by anatomical optical coherence tomography
    Peter B Noble
    Division of Clinical Sciences, Telethon Institute for Child Health Research, Roberts Road, Perth, 6008, Australia
    Respir Res 11:9. 2010
    ..Whilst heterogeneity has been detected by previous experimental approaches, its spatial relationship either within or between airways is unknown...
  23. doi request reprint Elastic properties of the central airways in obstructive lung diseases measured using anatomical optical coherence tomography
    Jonathan P Williamson
    Department of Pulmonary Physiology, Sir Charles Gairdner Hospital, Perth, Australia
    Am J Respir Crit Care Med 183:612-9. 2011
    ..Such knowledge could help elucidate mechanisms of excessive airway narrowing...
  24. ncbi request reprint Dyspnoea in COPD: can inspiratory muscle training help?
    Kylie Hill
    Department of Pulmonary Physiology, Sir Charles Gairdner Hospital, Nedlands, WA 6009, Australia
    Aust J Physiother 50:169-80. 2004
    ..This paper describes the origin of dyspnoea in COPD, with particular attention given to the role of inspiratory muscle dysfunction in its genesis and its possible amelioration through inspiratory muscle training...
  25. ncbi request reprint Obstructive sleep apnoea and anaesthesia
    David R Hillman
    West Australian Sleep Disorders Research Institute and Department of Pulmonary Physiology, Sir Charles Gairdner Hospital, Perth, WA, Australia
    Sleep Med Rev 8:459-71. 2004
    ..On the other hand difficulty with airway maintenance during anaesthesia should prompt further investigation for the possibility of OSA...
  26. ncbi request reprint Heterogeneous activity of the human genioglossus muscle assessed by multiple bipolar fine-wire electrodes
    Peter R Eastwood
    Department of Pulmonary Physiology, Sir Charles Gairdner Hospital, University of Western Australia, Australia 6009
    J Appl Physiol (1985) 94:1849-58. 2003
    ..We hypothesize that regional differences in density and type of muscle fiber are the most likely sources of heterogeneity in these responses...
  27. pmc Treating obstructive sleep apnea with hypoglossal nerve stimulation
    Peter R Eastwood
    Sir Charles Gairdner Hospital, Perth, Australia
    Sleep 34:1479-86. 2011
    ..Reduced upper airway muscle activity during sleep is fundamental to obstructive sleep apnea (OSA) pathogenesis. Hypoglossal nerve stimulation (HGNS) counteracts this problem, with potential to reduce OSA severity...
  28. ncbi request reprint Physiologic responses to incremental and self-paced exercise in COPD: a comparison of three tests
    Sian E Turner
    Physiotherapy Department, Sir Charles Gairdner Hospital, Hospital Avenue, Nedlands, WA, Australia
    Chest 126:766-73. 2004
    ..To investigate cardiorespiratory and dyspnea responses to incremental and self-paced exercise tests in patients with COPD...
  29. doi request reprint Using optical coherence tomography to improve diagnostic and therapeutic bronchoscopy
    Jonathan P Williamson
    Department of Pulmonary Physiology, Sir Charles Gairdner Hospital, Nedlands, Perth, WA 6009, Australia
    Chest 136:272-6. 2009
    ..The severity of newly diagnosed tracheomalacia was able to be quantified using aOCT imaging (subject 3). aOCT imaging during bronchoscopy allows accurate real-time airway measurements and may assist bronchoscopic assessment...
  30. pmc Interrelationships between body mass, oxygen desaturation, and apnea-hypopnea indices in a sleep clinic population
    Ivan T Ling
    West Australian Sleep Disorders Research Institute, Sir Charles Gairdner Hospital, Hospital Avenue, Nedlands WA 6009, Australia
    Sleep 35:89-96. 2012
    ..To investigate the relationship between oxygen desaturation index (ODI), body mass index (BMI), and apnea-hypopnea index (AHI) in a large sleep clinic population...
  31. ncbi request reprint The impact of continuous positive airway pressure on the lower esophageal sphincter
    Kelly L Shepherd
    West Australian Sleep Disorders Research Institute, Department of Pulmonary Physiology, Sir Charles Gairdner Hospital, Nedlands, Western Australia 6009, Australia
    Am J Physiol Gastrointest Liver Physiol 292:G1200-5. 2007
    ..The findings suggest CPAP may make the LES less susceptible to reflux by increasing Pb and decreasing the duration of LES relaxation...
  32. ncbi request reprint Function of the lower esophageal sphincter during and after high-intensity exercise
    Kathleen J Maddison
    Department of Pulmonary Physiology, Sir Charles Gairdner Hospital, University of Western Australia, Nedlands, Australia
    Med Sci Sports Exerc 37:1728-33. 2005
    ..The aim of this study was to determine the influence of exercise with and without ingestion of fluid on the LES barrier pressure in asymptomatic individuals...
  33. doi request reprint Obstructive Sleep Apnoea: From pathogenesis to treatment: Current controversies and future directions
    Peter R Eastwood
    West Australian Sleep Disorders Research Institute, Department of Pulmonary Physiology, Sir Charles Gairdner Hospital, Nedlands, WA 6009, Australia
    Respirology 15:587-95. 2010
    ....
  34. ncbi request reprint The economic cost of sleep disorders
    David R Hillman
    Sir Charles Gairdner Hospital, Perth, Australia
    Sleep 29:299-305. 2006
    ..To determine the economic cost of sleep disorders in Australia and relate these to likely costs in similar economies...
  35. ncbi request reprint The effect of learning on ventilatory responses to inspiratory threshold loading in COPD
    Gavin A Sturdy
    Department of Pulmonary Physiology, Sir Charles Gairdner Hospital, Nedlands, WA 6009, Australia
    Respir Med 98:1-8. 2004
    ..This study sought to determine whether a similar "learning effect" is evident in patients with COPD, and what the mechanism of any such effect may be...