Research Topics
| Ma FrenchSummaryAffiliation: Western Australia Country: Australia Publications
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Publications
Randomized, open-label, comparative trial to evaluate the efficacy and safety of three antiretroviral drug combinations including two nucleoside analogues and nevirapine for previously untreated HIV-1 Infection: the OzCombo 2 studyMartyn French
Department of Clinical Immunology and Biochemical Genetics, Royal Perth Hospital, Perth, WA, Australia
HIV Clin Trials 3:177-85. 2002..To assess and compare the efficacy and safety of three triple combination antiretroviral therapies in HIV-1-infected treatment-naive patients...- Disorders of immune reconstitution in patients with HIV infection responding to antiretroviral therapyMartyn A French
Department of Clinical Immunology, Royal Perth Hospital, GPO Box X2213, Perth, WA 6847, Australia
Curr HIV/AIDS Rep 4:16-21. 2007..Persistent CD4 T-cell deficiency (< 500/microL) affects up to 60% of patients and appears to reflect depletion of the naïve T-cell pool that results from low production and/or increased turnover of cells... - Susceptibility to opportunistic infections in HIV-infected patients with increased CD4 T-cell counts on antiretroviral therapy may be predicted by markers of dysfunctional effector memory CD4 T cells and B cellsMa French
Department of Clinical Immunology, Royal Perth Hospital, and School of Surgery and Pathology, University of Western Australia, Perth, Western Australia, Australia
HIV Med 8:148-55. 2007..The investigation of immune defects in such patients was examined in this study... 
HIV/AIDS: immune reconstitution inflammatory syndrome: a reappraisalMartyn A French
Department of Clinical Immunology and Immunogenetics, Royal Perth Hospital, Perth, Australia
Clin Infect Dis 48:101-7. 2009..Immune reconstitution after antiretroviral therapy may also be associated with autoimmune disease or sarcoidosis, both of which appear to have an immunopathogenesis that is different from that of IRD...- Immune restoration disease after antiretroviral therapyMartyn A French
Department of Clinical Immunology and Biochemical Genetics, Royal Perth Hospital and School of Surgery and Pathology, University of Western Australia, Perth, Australia
AIDS 18:1615-27. 2004..Investigation of strategies to prevent IRD is a priority, particularly in developing countries, and requires the development of risk assessment methods and diagnostic criteria... - Graves' disease during immune reconstitution after highly active antiretroviral therapy for HIV infection: evidence of thymic dysfunctionM A French
Department of Clinical Immunology and Biochemical Genetics, Royal Perth Hospital, Perth, Australia
AIDS Res Hum Retroviruses 20:157-62. 2004.... - Serum immune activation markers are persistently increased in patients with HIV infection after 6 years of antiretroviral therapy despite suppression of viral replication and reconstitution of CD4+ T cellsMartyn A French
School of Pathology and Laboratory Medicine, University of Western Australia, and Department of Clinical Immunology and Immunogenetics, Royal Perth Hospital and PathWest Laboratory Medicine, Perth, Australia
J Infect Dis 200:1212-5. 2009..Further investigation of the clinical usefulness of assaying immunoglobulin A, neopterin, and sCTLA-4 levels to assess the effectiveness of treatments for human immunodeficiency virus (HIV) disease are warranted... - Immune restoration disease: a consequence of dysregulated immune responses after HAARTShelley F Stone
Department of Clinical Immunology and Biochemical Genetics, Royal Perth Hospital and School of Surgery and Pathology, University of Western Australia, Perth, Australia
Curr HIV Res 2:235-42. 2004..It is therefore important to understand the immunopathology so that prevention, diagnosis and treatment can be improved... - The number and function of circulating dendritic cells may limit effector memory CD4+ T-cell responses in HIV patients responding to antiretroviral therapySonia Fernandez
Department of Clinical Immunology and Immunogenetics, Royal Perth Hospital, Perth, Australia
Clin Immunol 128:228-37. 2008..015) and levels of IL-10 mRNA were higher in M-DC8(+) cells from low responders (p=0.036). Hence CMV-specific CD4(+) T-cell IFN-gamma responses may be affected by numbers and function of circulating DC... - CXCR4 or CCR5 tropism of human immunodeficiency virus type 1 isolates does not determine the immunological milieu in patients responding to antiretroviral therapyPatricia Price
School of Surgery and Pathology, University of Western Australia, Perth, WA, Australia
Viral Immunol 19:734-40. 2006..Levels of LAG-3 (lymphocyte activation gene-3 protein) were elevated in patients with uncontrolled HIV replication. Hence the immunological milieu did not reflect HIV tropism... - Cell surface markers of regulatory T cells are not associated with increased forkhead box p3 expression in blood CD4+ T cells from HIV-infected patients responding to antiretroviral therapyAndrew Y F Lim
School of Surgery and Pathology, University of Western Australia, Perth, WA, Australia
Immunol Cell Biol 84:530-6. 2006..Hence, none of the putative Treg cell surface markers identified T-cell populations in peripheral blood that mirrored the effects of HIV infection and antiretroviral therapy on Foxp3 expression... - Proportions of circulating T cells with a regulatory cell phenotype increase with HIV-associated immune activation and remain high on antiretroviral therapyAndrew Lim
School of Surgery and Pathology, University of Western Australia, Rear 50 Murray Street, Perth 6000, Western Australia
AIDS 21:1525-34. 2007..Data were compared with established Treg cell markers (FoxP3, CTLA-4 and GITR)... - Recovery of CD4+ T Cells in HIV patients with a stable virologic response to antiretroviral therapy is associated with polymorphisms of interleukin-6 and central major histocompatibility complex genesSonia Fernandez
Clinical Immunology and Biochemical Genetics, Royal Perth Hospital, Perth, Western Australia, Australia
J Acquir Immune Defic Syndr 41:1-5. 2006..We suggest that immune activation and/or CD4 T-cell apoptosis in HIV patients on effective ART is influenced by genetic factors... - Interferon-gamma responses to Candida recover slowly or remain low in immunodeficient HIV patients responding to ARTKate Burgess
School of Surgery and Pathology, University of Western Australia, Nedlands, Australia
J Clin Immunol 26:160-7. 2006..Slow reconstitution of IFN-gamma responses to CMV and Candida in previously immunodeficient patients with restored CD4+ T-cell counts on CART suggests a broad and nonresolving defect in memory T-cell responses... - Thymic function in severely immunodeficient HIV type 1-infected patients receiving stable and effective antiretroviral therapySonia Fernandez
School of Surgery and Pathology, University of Western Australia, Department of Clinical Immunology and Biochemical Genetics, Royal Perth Hospital, The University of Melbourne, Melbourne, Australia
AIDS Res Hum Retroviruses 22:163-70. 2006..However, the data are consistent with extrathymic T cell production contributing to the naive T cell pool in some patients... - Circulating memory B-cell subpopulations are affected differently by HIV infection and antiretroviral therapyRom G Krueger
Department of Clinical Immunology and Immunogenetics, Royal Perth Hospital, Perth, WA 6847, Australia
AIDS 21:1747-52. 2007.... - Association of increased hepatitis C virus (HCV)-specific IgG and soluble CD26 dipeptidyl peptidase IV enzyme activity with hepatotoxicity after highly active antiretroviral therapy in human immunodeficiency virus-HCV-coinfected patientsShelley F Stone
Department of Clinical Immunology and Biochemical Genetics, Royal Perth Hospital, and Department of Pathology, University of Western Australia, Perth, Australia
J Infect Dis 186:1498-502. 2002..Thus, hepatotoxicity in HIV-HCV-coinfected patients who respond to HAART is associated with increased HCV-specific immune responses and T cell activation... - Parvovirus B19 encephalitis presenting as immune restoration disease after highly active antiretroviral therapy for human immunodeficiency virus infectionRichard C Nolan
Department of Clinical Immunology and Biochemical Genetics, Royal Perth Hospital, Perth WA 6001, Australia
Clin Infect Dis 36:1191-4. 2003..Neuroimaging demonstrated multiple right fronto-parietal lesions, and, following extensive investigations, including a brain biopsy, it was concluded that the brain lesions represented IRD associated with parvovirus B19 infection... - Alleles of the gene encoding IL-1alpha may predict control of plasma viraemia in HIV-1 patients on highly active antiretroviral therapyPatricia Price
Department of Clinical Immunology and Biochemical Genetics, Royal Perth Hospital, Perth, Australia
AIDS 18:1495-501. 2004..We investigate whether polymorphisms in cytokine genes affect the control of plasma HIV RNA over 5 years on HAART... - Polymorphisms in cytokine genes define subpopulations of HIV-1 patients who experienced immune restoration diseasesPatricia Price
Department of Clinical Immunology and Biochemical Genetics, Royal Perth Hospital, Australia
AIDS 16:2043-7. 2002.... - Cytomegalovirus (CMV) retinitis immune restoration disease occurs during highly active antiretroviral therapy-induced restoration of CMV-specific immune responses within a predominant Th2 cytokine environmentShelley F Stone
Department of Clinical Immunology and Biochemical Genetics, Royal Perth Hospital, GPO X2213, 6001 Perth, Australia
J Infect Dis 185:1813-7. 2002..Levels of sCD26 (DPP IV) enzyme activity and TNFR-I did not differ significantly between the 2 groups at any time point... - CD31 (PECAM-1) is a marker of recent thymic emigrants among CD4+ T-cells, but not CD8+ T-cells or gammadelta T-cells, in HIV patients responding to ARTSara Tanaskovic
School of Pathology and Laboratory Medicine, University of Western Australia, Perth, Australia
Immunol Cell Biol 88:321-7. 2010..In such patients, CD31 expression is unlikely to indicate thymic origin in gammadelta T-cells... - CD4+ and CD8+ T cells expressing FoxP3 in HIV-infected patients are phenotypically distinct and influenced by disease severity and antiretroviral therapyAndrew Lim
School of Pathology and Laboratory Medicine, University of Western Australia, Nedlands, Perth, Western Australia 6000, Australia
J Acquir Immune Defic Syndr 51:248-57. 2009..We assessed whether FoxP3 expression in CD8 T cells is associated with suppressive potential and/or with HIV-associated immune activation... 
A T2 cytokine environment may not limit T1 responses in human immunodeficiency virus patients with a favourable response to antiretroviral therapyPatricia Price
School of Surgery and Pathology, University of Western Australia, Australia
Immunology 119:74-82. 2006..These analyses provide no evidence for an inverse relationship between T1 and T2 cytokine responses in HIV patients, but suggest that the elevation of IgE marks low cytokine responses...- Low CD4+ T-cell counts in HIV patients receiving effective antiretroviral therapy are associated with CD4+ T-cell activation and senescence but not with lower effector memory T-cell functionSonia Fernandez
Department of Clinical Immunology and Biochemical Genetics, Royal Perth Hospital, Perth, Australia
Clin Immunol 120:163-70. 2006..This was clearest in patients with a small/undetectable thymus. IFN-gamma responses to CMV were similar in patients with low or high CD4(+) T-cell counts... - HIV patients on antiretroviral therapy have high frequencies of CD8 T cells specific for Immediate Early protein-1 of cytomegalovirusShelley F Stone
Department of Clinical Immunology and Biochemical Genetics, Royal Perth Hospital, Perth, Western Australia
AIDS 19:555-62. 2005..To assess the frequency and phenotype of cytomegalovirus (CMV)-specific CD8 T cells in previously immunocompromised HIV patients with stable undetectable HIV viremia due to highly active antiretroviral therapy (HAART)... - Mediators of innate and adaptive immune responses differentially affect immune restoration disease associated with Mycobacterium tuberculosis in HIV patients beginning antiretroviral therapyBenjamin G Oliver
School of Pathology and Laboratory Medicine, University of Western Australia, Perth, Australia
J Infect Dis 202:1728-37. 2010..Both conditions appear to be immune restoration disease but their immunopathogenesis is not completely understood... - Intrafamilial transmission of HIV-1 infection from individuals with unrecognized HIV-1 infectionMartyn A French
Department of Clinical Immunology and Biochemical Genetics, Royal Perth Hospital, Australia
AIDS 17:1977-81. 2003..CONCLUSION: Intra-familial transmission of HIV-1 infection should be considered when a source of HIV-1 infection cannot be determined... - Allogeneic hematopoietic stem cell transplantation recipients have defects of both switched and igm memory B cellsLloyd J D'Orsogna
Department of Clinical Immunology and Immunogenetics, Royal Perth Hospital and PathWest Laboratory Medicine, Perth, Australia
Biol Blood Marrow Transplant 15:795-803. 2009..The increased susceptibility of allogeneic HSCT patients to infection may reflect a combination of memory B cell defects, which are most common in patients with a history of GVHD... - Audit of paired anal cytology and histopathology outcomes in patients referred to a public sexual health clinicVincent M Williams
Western Australian Biomedical Research Institute, Curtin University of Technology, Perth, WA, Australia
Sex Health 7:346-51. 2010..The level of agreement between anal cytology and histopathology is not clear with only a few studies evaluating the reliability of anal specimen reporting. Australian data in relation to this are limited... - Perinatal HIV transmission and pregnancy outcomes in indigenous women in Western AustraliaMarisa T Gilles
Combined Universities Centre for Rural Health, Geraldton, WA, Australia
Aust N Z J Obstet Gynaecol 47:362-7. 2007..Implementation of obstetric and neonatal interventions has reduced mother to child transmission of HIV. Health outcomes for Aboriginal people are often worse than for non-Aboriginal people; was this the case for HIV infection in pregnancy?.. - Interferon-gamma response by peripheral blood mononuclear cells to hepatitis C virus core antigen is reduced in patients with liver fibrosisMark W Watson
Department of Microbiology and Infectious Diseases, Royal Perth Hospital, Perth, and School of Biomedical and Chemical Sciences, University of Western Australia, Nedlands, Australia
J Infect Dis 188:1533-6. 2003..IFN-gamma response by PBMCs to HCV core antigen may provide a useful marker of the severity of liver disease in patients with hepatitis C... - Compartmentalization of the immune response in varicella zoster virus immune restoration disease causing transverse myelitisBenjamin M Clark
AIDS 18:1218-21. 2004 - Tuberculosis-associated immune reconstitution inflammatory syndrome: case definitions for use in resource-limited settingsGraeme Meintjes
Institute of Infectious Diseases and Molecular Medicine and Department of Medicine, University of Cape Town, Cape Town, South Africa
Lancet Infect Dis 8:516-23. 2008..It is envisaged that these definitions could be used by clinicians and researchers in a variety of settings to promote standardisation and comparability of data... - 'Tuberculosis' after commencing antiretroviral therapy in HIV patients from countries where Mycobacterium tuberculosis infection is commonMartyn A French
AIDS 20:473-4. 2006 - The immunopathogenesis of mycobacterial immune restoration diseaseMartyn A French
Lancet Infect Dis 6:461-2. 2006 - Pulmonary Mycobacterium celatum immune restoration disease: immunopathology and response to corticosteroid therapyHelen C Bell
AIDS 19:2047-9. 2005 - Killer immunoglobulin-like receptor genotype may distinguish immunodeficient HIV-infected patients resistant to immune restoration diseases associated with herpes virus infectionsPatricia Price
J Acquir Immune Defic Syndr 45:359-61. 2007