Ma French

Summary

Affiliation: Western Australia
Country: Australia

Publications

  1. pmc Tuberculosis associated immune reconstitution inflammatory syndrome in patients infected with HIV: meningitis a potentially life threatening manifestation
    Upasna Agarwal
    LRS Institute of Tuberculosis and Respiratory Diseases, Sri Aurobindo Marg, near Qutab Minar, New Delhi, India, 110 030
    AIDS Res Ther 9:17. 2012
  2. doi request reprint Serum immune activation markers are persistently increased in patients with HIV infection after 6 years of antiretroviral therapy despite suppression of viral replication and reconstitution of CD4+ T cells
    Martyn A French
    School of Pathology and Laboratory Medicine, University of Western Australia, and Department of Clinical Immunology and Immunogenetics, Royal Perth Hospital and PathWest Laboratory Medicine, Perth, Australia
    J Infect Dis 200:1212-5. 2009
  3. doi request reprint HIV/AIDS: immune reconstitution inflammatory syndrome: a reappraisal
    Martyn A French
    Department of Clinical Immunology and Immunogenetics, Royal Perth Hospital, Perth, Australia
    Clin Infect Dis 48:101-7. 2009
  4. ncbi request reprint Susceptibility to opportunistic infections in HIV-infected patients with increased CD4 T-cell counts on antiretroviral therapy may be predicted by markers of dysfunctional effector memory CD4 T cells and B cells
    Ma French
    Department of Clinical Immunology, Royal Perth Hospital, and School of Surgery and Pathology, University of Western Australia, Perth, Western Australia, Australia
    HIV Med 8:148-55. 2007
  5. ncbi request reprint Disorders of immune reconstitution in patients with HIV infection responding to antiretroviral therapy
    Martyn A French
    Department of Clinical Immunology, Royal Perth Hospital, GPO Box X2213, Perth, WA 6847, Australia
    Curr HIV/AIDS Rep 4:16-21. 2007
  6. ncbi request reprint Randomized, open-label, comparative trial to evaluate the efficacy and safety of three antiretroviral drug combinations including two nucleoside analogues and nevirapine for previously untreated HIV-1 Infection: the OzCombo 2 study
    Martyn French
    Department of Clinical Immunology and Biochemical Genetics, Royal Perth Hospital, Perth, WA, Australia
    HIV Clin Trials 3:177-85. 2002
  7. ncbi request reprint Immune restoration disease after antiretroviral therapy
    Martyn A French
    Department of Clinical Immunology and Biochemical Genetics, Royal Perth Hospital and School of Surgery and Pathology, University of Western Australia, Perth, Australia
    AIDS 18:1615-27. 2004
  8. ncbi request reprint Graves' disease during immune reconstitution after highly active antiretroviral therapy for HIV infection: evidence of thymic dysfunction
    M A French
    Department of Clinical Immunology and Biochemical Genetics, Royal Perth Hospital, Perth, Australia
    AIDS Res Hum Retroviruses 20:157-62. 2004
  9. ncbi request reprint Immune restoration disease: a consequence of dysregulated immune responses after HAART
    Shelley F Stone
    Department of Clinical Immunology and Biochemical Genetics, Royal Perth Hospital and School of Surgery and Pathology, University of Western Australia, Perth, Australia
    Curr HIV Res 2:235-42. 2004
  10. doi request reprint The number and function of circulating dendritic cells may limit effector memory CD4+ T-cell responses in HIV patients responding to antiretroviral therapy
    Sonia Fernandez
    Department of Clinical Immunology and Immunogenetics, Royal Perth Hospital, Perth, Australia
    Clin Immunol 128:228-37. 2008

Collaborators

Detail Information

Publications39

  1. pmc Tuberculosis associated immune reconstitution inflammatory syndrome in patients infected with HIV: meningitis a potentially life threatening manifestation
    Upasna Agarwal
    LRS Institute of Tuberculosis and Respiratory Diseases, Sri Aurobindo Marg, near Qutab Minar, New Delhi, India, 110 030
    AIDS Res Ther 9:17. 2012
    ..abstract:..
  2. doi request reprint Serum immune activation markers are persistently increased in patients with HIV infection after 6 years of antiretroviral therapy despite suppression of viral replication and reconstitution of CD4+ T cells
    Martyn A French
    School of Pathology and Laboratory Medicine, University of Western Australia, and Department of Clinical Immunology and Immunogenetics, Royal Perth Hospital and PathWest Laboratory Medicine, Perth, Australia
    J Infect Dis 200:1212-5. 2009
    ..Further investigation of the clinical usefulness of assaying immunoglobulin A, neopterin, and sCTLA-4 levels to assess the effectiveness of treatments for human immunodeficiency virus (HIV) disease are warranted...
  3. doi request reprint HIV/AIDS: immune reconstitution inflammatory syndrome: a reappraisal
    Martyn A French
    Department of Clinical Immunology and Immunogenetics, Royal Perth Hospital, Perth, Australia
    Clin Infect Dis 48:101-7. 2009
    ..Immune reconstitution after antiretroviral therapy may also be associated with autoimmune disease or sarcoidosis, both of which appear to have an immunopathogenesis that is different from that of IRD...
  4. ncbi request reprint Susceptibility to opportunistic infections in HIV-infected patients with increased CD4 T-cell counts on antiretroviral therapy may be predicted by markers of dysfunctional effector memory CD4 T cells and B cells
    Ma French
    Department of Clinical Immunology, Royal Perth Hospital, and School of Surgery and Pathology, University of Western Australia, Perth, Western Australia, Australia
    HIV Med 8:148-55. 2007
    ..The investigation of immune defects in such patients was examined in this study...
  5. ncbi request reprint Disorders of immune reconstitution in patients with HIV infection responding to antiretroviral therapy
    Martyn A French
    Department of Clinical Immunology, Royal Perth Hospital, GPO Box X2213, Perth, WA 6847, Australia
    Curr HIV/AIDS Rep 4:16-21. 2007
    ..Persistent CD4 T-cell deficiency (< 500/microL) affects up to 60% of patients and appears to reflect depletion of the naïve T-cell pool that results from low production and/or increased turnover of cells...
  6. ncbi request reprint Randomized, open-label, comparative trial to evaluate the efficacy and safety of three antiretroviral drug combinations including two nucleoside analogues and nevirapine for previously untreated HIV-1 Infection: the OzCombo 2 study
    Martyn French
    Department of Clinical Immunology and Biochemical Genetics, Royal Perth Hospital, Perth, WA, Australia
    HIV Clin Trials 3:177-85. 2002
    ..To assess and compare the efficacy and safety of three triple combination antiretroviral therapies in HIV-1-infected treatment-naive patients...
  7. ncbi request reprint Immune restoration disease after antiretroviral therapy
    Martyn A French
    Department of Clinical Immunology and Biochemical Genetics, Royal Perth Hospital and School of Surgery and Pathology, University of Western Australia, Perth, Australia
    AIDS 18:1615-27. 2004
    ..Investigation of strategies to prevent IRD is a priority, particularly in developing countries, and requires the development of risk assessment methods and diagnostic criteria...
  8. ncbi request reprint Graves' disease during immune reconstitution after highly active antiretroviral therapy for HIV infection: evidence of thymic dysfunction
    M A French
    Department of Clinical Immunology and Biochemical Genetics, Royal Perth Hospital, Perth, Australia
    AIDS Res Hum Retroviruses 20:157-62. 2004
    ....
  9. ncbi request reprint Immune restoration disease: a consequence of dysregulated immune responses after HAART
    Shelley F Stone
    Department of Clinical Immunology and Biochemical Genetics, Royal Perth Hospital and School of Surgery and Pathology, University of Western Australia, Perth, Australia
    Curr HIV Res 2:235-42. 2004
    ..It is therefore important to understand the immunopathology so that prevention, diagnosis and treatment can be improved...
  10. doi request reprint The number and function of circulating dendritic cells may limit effector memory CD4+ T-cell responses in HIV patients responding to antiretroviral therapy
    Sonia Fernandez
    Department of Clinical Immunology and Immunogenetics, Royal Perth Hospital, Perth, Australia
    Clin Immunol 128:228-37. 2008
    ..015) and levels of IL-10 mRNA were higher in M-DC8(+) cells from low responders (p=0.036). Hence CMV-specific CD4(+) T-cell IFN-gamma responses may be affected by numbers and function of circulating DC...
  11. ncbi request reprint CXCR4 or CCR5 tropism of human immunodeficiency virus type 1 isolates does not determine the immunological milieu in patients responding to antiretroviral therapy
    Patricia Price
    School of Surgery and Pathology, University of Western Australia, Perth, WA, Australia
    Viral Immunol 19:734-40. 2006
    ..Levels of LAG-3 (lymphocyte activation gene-3 protein) were elevated in patients with uncontrolled HIV replication. Hence the immunological milieu did not reflect HIV tropism...
  12. ncbi request reprint Cell surface markers of regulatory T cells are not associated with increased forkhead box p3 expression in blood CD4+ T cells from HIV-infected patients responding to antiretroviral therapy
    Andrew Y F Lim
    School of Surgery and Pathology, University of Western Australia, Perth, WA, Australia
    Immunol Cell Biol 84:530-6. 2006
    ..Hence, none of the putative Treg cell surface markers identified T-cell populations in peripheral blood that mirrored the effects of HIV infection and antiretroviral therapy on Foxp3 expression...
  13. ncbi request reprint Proportions of circulating T cells with a regulatory cell phenotype increase with HIV-associated immune activation and remain high on antiretroviral therapy
    Andrew Lim
    School of Surgery and Pathology, University of Western Australia, Rear 50 Murray Street, Perth 6000, Western Australia
    AIDS 21:1525-34. 2007
    ..Data were compared with established Treg cell markers (FoxP3, CTLA-4 and GITR)...
  14. ncbi request reprint Recovery of CD4+ T Cells in HIV patients with a stable virologic response to antiretroviral therapy is associated with polymorphisms of interleukin-6 and central major histocompatibility complex genes
    Sonia Fernandez
    Clinical Immunology and Biochemical Genetics, Royal Perth Hospital, Perth, Western Australia, Australia
    J Acquir Immune Defic Syndr 41:1-5. 2006
    ..We suggest that immune activation and/or CD4 T-cell apoptosis in HIV patients on effective ART is influenced by genetic factors...
  15. ncbi request reprint Thymic function in severely immunodeficient HIV type 1-infected patients receiving stable and effective antiretroviral therapy
    Sonia Fernandez
    School of Surgery and Pathology, University of Western Australia, Department of Clinical Immunology and Biochemical Genetics, Royal Perth Hospital, The University of Melbourne, Melbourne, Australia
    AIDS Res Hum Retroviruses 22:163-70. 2006
    ..However, the data are consistent with extrathymic T cell production contributing to the naive T cell pool in some patients...
  16. ncbi request reprint Circulating memory B-cell subpopulations are affected differently by HIV infection and antiretroviral therapy
    Rom G Krueger
    Department of Clinical Immunology and Immunogenetics, Royal Perth Hospital, Perth, WA 6847, Australia
    AIDS 21:1747-52. 2007
    ....
  17. ncbi request reprint Interferon-gamma responses to Candida recover slowly or remain low in immunodeficient HIV patients responding to ART
    Kate Burgess
    School of Surgery and Pathology, University of Western Australia, Nedlands, Australia
    J Clin Immunol 26:160-7. 2006
    ..Slow reconstitution of IFN-gamma responses to CMV and Candida in previously immunodeficient patients with restored CD4+ T-cell counts on CART suggests a broad and nonresolving defect in memory T-cell responses...
  18. ncbi request reprint Parvovirus B19 encephalitis presenting as immune restoration disease after highly active antiretroviral therapy for human immunodeficiency virus infection
    Richard C Nolan
    Department of Clinical Immunology and Biochemical Genetics, Royal Perth Hospital, Perth WA 6001, Australia
    Clin Infect Dis 36:1191-4. 2003
    ..Neuroimaging demonstrated multiple right fronto-parietal lesions, and, following extensive investigations, including a brain biopsy, it was concluded that the brain lesions represented IRD associated with parvovirus B19 infection...
  19. ncbi request reprint Polymorphisms in cytokine genes define subpopulations of HIV-1 patients who experienced immune restoration diseases
    Patricia Price
    Department of Clinical Immunology and Biochemical Genetics, Royal Perth Hospital, Australia
    AIDS 16:2043-7. 2002
    ....
  20. ncbi request reprint Cytomegalovirus (CMV) retinitis immune restoration disease occurs during highly active antiretroviral therapy-induced restoration of CMV-specific immune responses within a predominant Th2 cytokine environment
    Shelley F Stone
    Department of Clinical Immunology and Biochemical Genetics, Royal Perth Hospital, GPO X2213, 6001 Perth, Australia
    J Infect Dis 185:1813-7. 2002
    ..Levels of sCD26 (DPP IV) enzyme activity and TNFR-I did not differ significantly between the 2 groups at any time point...
  21. doi request reprint CD31 (PECAM-1) is a marker of recent thymic emigrants among CD4+ T-cells, but not CD8+ T-cells or gammadelta T-cells, in HIV patients responding to ART
    Sara Tanaskovic
    School of Pathology and Laboratory Medicine, University of Western Australia, Perth, Australia
    Immunol Cell Biol 88:321-7. 2010
    ..In such patients, CD31 expression is unlikely to indicate thymic origin in gammadelta T-cells...
  22. ncbi request reprint Alleles of the gene encoding IL-1alpha may predict control of plasma viraemia in HIV-1 patients on highly active antiretroviral therapy
    Patricia Price
    Department of Clinical Immunology and Biochemical Genetics, Royal Perth Hospital, Perth, Australia
    AIDS 18:1495-501. 2004
    ..We investigate whether polymorphisms in cytokine genes affect the control of plasma HIV RNA over 5 years on HAART...
  23. ncbi request reprint Association of increased hepatitis C virus (HCV)-specific IgG and soluble CD26 dipeptidyl peptidase IV enzyme activity with hepatotoxicity after highly active antiretroviral therapy in human immunodeficiency virus-HCV-coinfected patients
    Shelley F Stone
    Department of Clinical Immunology and Biochemical Genetics, Royal Perth Hospital, and Department of Pathology, University of Western Australia, Perth, Australia
    J Infect Dis 186:1498-502. 2002
    ..Thus, hepatotoxicity in HIV-HCV-coinfected patients who respond to HAART is associated with increased HCV-specific immune responses and T cell activation...
  24. doi request reprint CD4+ and CD8+ T cells expressing FoxP3 in HIV-infected patients are phenotypically distinct and influenced by disease severity and antiretroviral therapy
    Andrew Lim
    School of Pathology and Laboratory Medicine, University of Western Australia, Nedlands, Perth, Western Australia 6000, Australia
    J Acquir Immune Defic Syndr 51:248-57. 2009
    ..We assessed whether FoxP3 expression in CD8 T cells is associated with suppressive potential and/or with HIV-associated immune activation...
  25. pmc A T2 cytokine environment may not limit T1 responses in human immunodeficiency virus patients with a favourable response to antiretroviral therapy
    Patricia Price
    School of Surgery and Pathology, University of Western Australia, Australia
    Immunology 119:74-82. 2006
    ..These analyses provide no evidence for an inverse relationship between T1 and T2 cytokine responses in HIV patients, but suggest that the elevation of IgE marks low cytokine responses...
  26. ncbi request reprint Low CD4+ T-cell counts in HIV patients receiving effective antiretroviral therapy are associated with CD4+ T-cell activation and senescence but not with lower effector memory T-cell function
    Sonia Fernandez
    Department of Clinical Immunology and Biochemical Genetics, Royal Perth Hospital, Perth, Australia
    Clin Immunol 120:163-70. 2006
    ..This was clearest in patients with a small/undetectable thymus. IFN-gamma responses to CMV were similar in patients with low or high CD4(+) T-cell counts...
  27. ncbi request reprint HIV patients on antiretroviral therapy have high frequencies of CD8 T cells specific for Immediate Early protein-1 of cytomegalovirus
    Shelley F Stone
    Department of Clinical Immunology and Biochemical Genetics, Royal Perth Hospital, Perth, Western Australia
    AIDS 19:555-62. 2005
    ..To assess the frequency and phenotype of cytomegalovirus (CMV)-specific CD8 T cells in previously immunocompromised HIV patients with stable undetectable HIV viremia due to highly active antiretroviral therapy (HAART)...
  28. doi request reprint Mediators of innate and adaptive immune responses differentially affect immune restoration disease associated with Mycobacterium tuberculosis in HIV patients beginning antiretroviral therapy
    Benjamin G Oliver
    School of Pathology and Laboratory Medicine, University of Western Australia, Perth, Australia
    J Infect Dis 202:1728-37. 2010
    ..Both conditions appear to be immune restoration disease but their immunopathogenesis is not completely understood...
  29. ncbi request reprint Intrafamilial transmission of HIV-1 infection from individuals with unrecognized HIV-1 infection
    Martyn A French
    Department of Clinical Immunology and Biochemical Genetics, Royal Perth Hospital, Australia
    AIDS 17:1977-81. 2003
    ....
  30. doi request reprint Allogeneic hematopoietic stem cell transplantation recipients have defects of both switched and igm memory B cells
    Lloyd J D'Orsogna
    Department of Clinical Immunology and Immunogenetics, Royal Perth Hospital and PathWest Laboratory Medicine, Perth, Australia
    Biol Blood Marrow Transplant 15:795-803. 2009
    ..The increased susceptibility of allogeneic HSCT patients to infection may reflect a combination of memory B cell defects, which are most common in patients with a history of GVHD...
  31. doi request reprint Audit of paired anal cytology and histopathology outcomes in patients referred to a public sexual health clinic
    Vincent M Williams
    Western Australian Biomedical Research Institute, Curtin University of Technology, Perth, WA, Australia
    Sex Health 7:346-51. 2010
    ..The level of agreement between anal cytology and histopathology is not clear with only a few studies evaluating the reliability of anal specimen reporting. Australian data in relation to this are limited...
  32. ncbi request reprint Perinatal HIV transmission and pregnancy outcomes in indigenous women in Western Australia
    Marisa T Gilles
    Combined Universities Centre for Rural Health, Geraldton, WA, Australia
    Aust N Z J Obstet Gynaecol 47:362-7. 2007
    ..Implementation of obstetric and neonatal interventions has reduced mother to child transmission of HIV. Health outcomes for Aboriginal people are often worse than for non-Aboriginal people; was this the case for HIV infection in pregnancy?..
  33. ncbi request reprint Interferon-gamma response by peripheral blood mononuclear cells to hepatitis C virus core antigen is reduced in patients with liver fibrosis
    Mark W Watson
    Department of Microbiology and Infectious Diseases, Royal Perth Hospital, Perth, and School of Biomedical and Chemical Sciences, University of Western Australia, Nedlands, Australia
    J Infect Dis 188:1533-6. 2003
    ..IFN-gamma response by PBMCs to HCV core antigen may provide a useful marker of the severity of liver disease in patients with hepatitis C...
  34. ncbi request reprint 'Tuberculosis' after commencing antiretroviral therapy in HIV patients from countries where Mycobacterium tuberculosis infection is common
    Martyn A French
    AIDS 20:473-4. 2006
  35. pmc Tuberculosis-associated immune reconstitution inflammatory syndrome: case definitions for use in resource-limited settings
    Graeme Meintjes
    Institute of Infectious Diseases and Molecular Medicine and Department of Medicine, University of Cape Town, Cape Town, South Africa
    Lancet Infect Dis 8:516-23. 2008
    ..It is envisaged that these definitions could be used by clinicians and researchers in a variety of settings to promote standardisation and comparability of data...
  36. ncbi request reprint The immunopathogenesis of mycobacterial immune restoration disease
    Martyn A French
    Lancet Infect Dis 6:461-2. 2006
  37. ncbi request reprint Compartmentalization of the immune response in varicella zoster virus immune restoration disease causing transverse myelitis
    Benjamin M Clark
    AIDS 18:1218-21. 2004
  38. ncbi request reprint Pulmonary Mycobacterium celatum immune restoration disease: immunopathology and response to corticosteroid therapy
    Helen C Bell
    AIDS 19:2047-9. 2005
  39. ncbi request reprint Killer immunoglobulin-like receptor genotype may distinguish immunodeficient HIV-infected patients resistant to immune restoration diseases associated with herpes virus infections
    Patricia Price
    J Acquir Immune Defic Syndr 45:359-61. 2007