Alex Fornito

Summary

Affiliation: Western Hospital
Country: Australia

Publications

  1. ncbi request reprint Individual differences in anterior cingulate/paracingulate morphology are related to executive functions in healthy males
    Alexander Fornito
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne, Sunshine Hospital, 176 Furlong Road, St Albans, Victoria 3021, Australia
    Cereb Cortex 14:424-31. 2004
  2. ncbi request reprint Morphology of the paracingulate sulcus and executive cognition in schizophrenia
    Alex Fornito
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne, National Neuroscience Facility, Levels 2 and 3, Alan Gilbert Building, 161 Barry St, Carlton South, Victoria 3053, Australia
    Schizophr Res 88:192-7. 2006
  3. ncbi request reprint The influence of sulcal variability on morphometry of the human anterior cingulate and paracingulate cortex
    Alex Fornito
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne, Australia
    Neuroimage 33:843-54. 2006
  4. doi request reprint Anterior cingulate cortex abnormalities associated with a first psychotic episode in bipolar disorder
    Alex Fornito
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, School of Behavioural Science, University of Melbourne, National Neuroscience Facility, 161 Barry Street, Carlton South, VIC 3053, Australia
    Br J Psychiatry 194:426-33. 2009
  5. doi request reprint Inhibitory control in young adolescents: the role of sex, intelligence, and temperament
    Murat Yucel
    The University of Melbourne, Melbourne Health, Melbourne, Victoria, Australia
    Neuropsychology 26:347-56. 2012
  6. doi request reprint Anterior cingulate glutamate-glutamine levels predict symptom severity in women with obsessive-compulsive disorder
    Murat Yucel
    Melbourne Neuropsychiatry Centre, National Neuroscience Facility, Carlton South, Australia
    Aust N Z J Psychiatry 42:467-77. 2008
  7. pmc Brain functional connectivity during induced sadness in patients with obsessive-compulsive disorder
    Leonardo F Fontenelle
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Australia
    J Psychiatry Neurosci 37:231-40. 2012
  8. ncbi request reprint Surface-based morphometry of the anterior cingulate cortex in first episode schizophrenia
    Alex Fornito
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Australia
    Hum Brain Mapp 29:478-89. 2008
  9. pmc Anatomical abnormalities of the anterior cingulate cortex in schizophrenia: bridging the gap between neuroimaging and neuropathology
    Alex Fornito
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne, Victoria, Australia
    Schizophr Bull 35:973-93. 2009
  10. doi request reprint Functional alterations of large-scale brain networks related to cognitive control in obsessive-compulsive disorder
    Luca Cocchi
    Melbourne Neuropsychiatry Centre, The University of Melbourne, Australia
    Hum Brain Mapp 33:1089-106. 2012

Detail Information

Publications48

  1. ncbi request reprint Individual differences in anterior cingulate/paracingulate morphology are related to executive functions in healthy males
    Alexander Fornito
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne, Sunshine Hospital, 176 Furlong Road, St Albans, Victoria 3021, Australia
    Cereb Cortex 14:424-31. 2004
    ..It therefore appears that normal variations in brain morphology are associated with individual differences in cognitive abilities...
  2. ncbi request reprint Morphology of the paracingulate sulcus and executive cognition in schizophrenia
    Alex Fornito
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne, National Neuroscience Facility, Levels 2 and 3, Alan Gilbert Building, 161 Barry St, Carlton South, Victoria 3053, Australia
    Schizophr Res 88:192-7. 2006
    ..This suggests that prior reports of impaired performance on such tasks in schizophrenia may be partly explained by the reduced frequency of a leftward PCS asymmetry in this population...
  3. ncbi request reprint The influence of sulcal variability on morphometry of the human anterior cingulate and paracingulate cortex
    Alex Fornito
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne, Australia
    Neuroimage 33:843-54. 2006
    ....
  4. doi request reprint Anterior cingulate cortex abnormalities associated with a first psychotic episode in bipolar disorder
    Alex Fornito
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, School of Behavioural Science, University of Melbourne, National Neuroscience Facility, 161 Barry Street, Carlton South, VIC 3053, Australia
    Br J Psychiatry 194:426-33. 2009
    ....
  5. doi request reprint Inhibitory control in young adolescents: the role of sex, intelligence, and temperament
    Murat Yucel
    The University of Melbourne, Melbourne Health, Melbourne, Victoria, Australia
    Neuropsychology 26:347-56. 2012
    ..However, sex differences in inhibitory control are often not expressed experimentally during task performance. Here, we sought to examine how sex, temperament, and intelligence are related to different aspects of inhibitory control...
  6. doi request reprint Anterior cingulate glutamate-glutamine levels predict symptom severity in women with obsessive-compulsive disorder
    Murat Yucel
    Melbourne Neuropsychiatry Centre, National Neuroscience Facility, Carlton South, Australia
    Aust N Z J Psychiatry 42:467-77. 2008
    ..The purpose of the present study was to investigate how ACC biochemistry in OCD varies as a function of gender, hemisphere, subregion, and symptomatology...
  7. pmc Brain functional connectivity during induced sadness in patients with obsessive-compulsive disorder
    Leonardo F Fontenelle
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Australia
    J Psychiatry Neurosci 37:231-40. 2012
    ....
  8. ncbi request reprint Surface-based morphometry of the anterior cingulate cortex in first episode schizophrenia
    Alex Fornito
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Australia
    Hum Brain Mapp 29:478-89. 2008
    ....
  9. pmc Anatomical abnormalities of the anterior cingulate cortex in schizophrenia: bridging the gap between neuroimaging and neuropathology
    Alex Fornito
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne, Victoria, Australia
    Schizophr Bull 35:973-93. 2009
    ..We discuss the potential mechanisms that might facilitate integration of these findings and consider strategies for future research...
  10. doi request reprint Functional alterations of large-scale brain networks related to cognitive control in obsessive-compulsive disorder
    Luca Cocchi
    Melbourne Neuropsychiatry Centre, The University of Melbourne, Australia
    Hum Brain Mapp 33:1089-106. 2012
    ..The goal of this study was to extend such observations by investigating large-scale brain functional network correlates of cognitive-control performance in OCD patients...
  11. doi request reprint Disrupted axonal fiber connectivity in schizophrenia
    Andrew Zalesky
    Melbourne Neuropsychiatry Centre, The University of Melbourne, Melbourne, Victoria VIC, Australia
    Biol Psychiatry 69:80-9. 2011
    ..However, evidence for anatomical dysconnectivity has been equivocal, and few studies have examined axonal fiber connectivity in schizophrenia at the level of whole-brain networks...
  12. doi request reprint Variations in cortical folding patterns are related to individual differences in temperament
    Sarah Whittle
    ORYGEN Research Centre, Department of Psychiatry, The University of Melbourne, Victoria, Australia
    Psychiatry Res 172:68-74. 2009
    ..These findings suggest that early neurodevelopmental processes contribute to individual differences in temperament. They also illustrate sexual dimorphisms in the neural underpinnings of temperament...
  13. doi request reprint Anatomic abnormalities of the anterior cingulate cortex before psychosis onset: an MRI study of ultra-high-risk individuals
    Alex Fornito
    Department of Psychiatry, Melbourne Neuropsychiatry Centre, University of Melbourne, Carlton South, Victoria, Australia
    Biol Psychiatry 64:758-65. 2008
    ..In this study, we characterized prepsychotic ACC abnormalities in a sample of individuals at ultra-high-risk (UHR) for psychosis...
  14. ncbi request reprint Evidence for neuronal dysfunction in the anterior cingulate of patients with schizophrenia: a proton magnetic resonance spectroscopy study at 3 T
    Stephen J Wood
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne, Australia
    Schizophr Res 94:328-31. 2007
    ..Anterior cingulate involvement in schizophrenia is likely to be a result of neuronal loss or dysfunction...
  15. ncbi request reprint Functional and biochemical alterations of the medial frontal cortex in obsessive-compulsive disorder
    Murat Yucel
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Victoria 3053, Australia
    Arch Gen Psychiatry 64:946-55. 2007
    ..However, the precise regions and the neural alterations associated with this abnormality remain unclear...
  16. doi request reprint White matter microstructure in opiate addiction
    Emre Bora
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Australia
    Addict Biol 17:141-8. 2012
    ..Together, the findings indicate that chronic OA use has widespread and diverse effects on neuronal connectivity and function...
  17. doi request reprint Neuroanatomical correlates of temperament in early adolescents
    Sarah Whittle
    Department of Psychiatry, University of Melbourne, Victoria 3052, Australia
    J Am Acad Child Adolesc Psychiatry 47:682-93. 2008
    ..In the present study, we examined the relation between four core temperament dimensions and anatomically defined regions of the limbic and prefrontal cortices...
  18. pmc White matter microstructure in patients with obsessive-compulsive disorder
    Emre Bora
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Victoria, Australia
    J Psychiatry Neurosci 36:42-6. 2011
    ....
  19. doi request reprint Anterior cingulate volume in adolescents with first-presentation borderline personality disorder
    Sarah Whittle
    ORYGEN Research Centre, Department of Psychiatry, The University of Melbourne, Melbourne, Australia
    Psychiatry Res 172:155-60. 2009
    ..Longitudinal studies are needed to examine the nature of this abnormality over the course of the disorder...
  20. doi request reprint Neuroanatomical abnormalities in schizophrenia: a multimodal voxelwise meta-analysis and meta-regression analysis
    Emre Bora
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Level 3, National Neuroscience Facility, Alan Gilbert Building, 161, Barry St, Carlton South, Vic, 3053, Australia
    Schizophr Res 127:46-57. 2011
    ..However, the available findings are biased towards characteristics of schizophrenia samples with poor prognosis...
  21. ncbi request reprint Variability of the paracingulate sulcus and morphometry of the medial frontal cortex: associations with cortical thickness, surface area, volume, and sulcal depth
    Alex Fornito
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne, Melbourne, Australia
    Hum Brain Mapp 29:222-36. 2008
    ....
  22. pmc Progressive changes in the development toward schizophrenia: studies in subjects at increased symptomatic risk
    Stephen J Wood
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne, Australia
    Schizophr Bull 34:322-9. 2008
    ..Active changes during transition to illness may present the potential to intervene and ameliorate these changes with potential benefit clinically...
  23. doi request reprint Reconciling neuroimaging and neuropathological findings in schizophrenia and bipolar disorder
    Alex Fornito
    Faculty of Medicine, Dentistry and Health Science, Department of Psychiatry, Melbourne Neuropsychiatry Centre, The University of Melbourne, Parkville, Victoria, Australia
    Curr Opin Psychiatry 22:312-9. 2009
    ..In this study, we overview recent sMRI findings in schizophrenia and bipolar disorder and consider how they relate to neuropathological data...
  24. doi request reprint Structural brain abnormalities in major depressive disorder: a selective review of recent MRI studies
    Valentina Lorenzetti
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, Australia
    J Affect Disord 117:1-17. 2009
    ..While there is evidence to suggest that major depressive disorder (MDD) is associated with structural brain abnormalities, the precise nature of these abnormalities remains unclear...
  25. doi request reprint Abnormal white matter microstructure in schizophrenia: a voxelwise analysis of axial and radial diffusivity
    Marc L Seal
    Melbourne Neuropsychiatry Centre, The University of Melbourne, Victoria, Australia
    Schizophr Res 101:106-10. 2008
    ..This finding suggests that the loss of white matter integrity in schizophrenia is the result of demyelination and/or changes to the axonal cytoskeleton rather than gross axonal damage...
  26. doi request reprint The relationship between regional and inter-regional functional connectivity deficits in schizophrenia
    Andrew Zalesky
    Melbourne Neuropsychiatry Centre, The University of Melbourne and Melbourne Health, Melbourne, Australia
    Hum Brain Mapp 33:2535-49. 2012
    ..This suggests measurement of aberrant functional connectivity in schizophrenia is both a measurement of altered coupling between regions as well as a measurement of local decoherence within regions...
  27. pmc The impact of cannabis use on cognitive functioning in patients with schizophrenia: a meta-analysis of existing findings and new data in a first-episode sample
    Murat Yucel
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, National Neuroscience Facility, Alan Gilbert Building, 161 Barry Street, Carlton South, Victoria 3053, Australia
    Schizophr Bull 38:316-30. 2012
    ....
  28. doi request reprint Anatomical abnormalities of the anterior cingulate and paracingulate cortex in patients with bipolar I disorder
    Alex Fornito
    Melbourne Neuropsychiatry Centre, The University of Melbourne, Melbourne, Australia
    Psychiatry Res 162:123-32. 2008
    ..These findings suggest that bipolar disorder is associated with more pronounced changes in the PaC, and that reliance on volumetric measures alone may obscure more subtle differences...
  29. pmc Decreased functional brain connectivity in adolescents with internet addiction
    Soon Beom Hong
    Melbourne Neuropsychiatry Center, Department of Psychiatry, University of Melbourne and Melbourne Health, Parkville, Victoria, Australia
    PLoS ONE 8:e57831. 2013
    ..Based on neurobiological changes seen in other addiction related disorders, it was predicted that connectivity disruptions in adolescents with internet addiction would be most prominent in cortico-striatal circuitry...
  30. ncbi request reprint Functional dysconnectivity of corticostriatal circuitry as a risk phenotype for psychosis
    Alex Fornito
    Monash Clinical and Imaging Neuroscience Laboratory, School of Psychology and Psychiatry, Monash University, Clayton, Victoria, Australia2Centre for Neural Engineering, University of Melbourne, Parkville, Victoria, Australia3NICTA Victorian Research Laboratory, University of Melbourne, Parkville, Victoria, Australia4Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Parkville, Victoria, Australia
    JAMA Psychiatry 70:1143-51. 2013
    ....
  31. doi request reprint Schizophrenia, neuroimaging and connectomics
    Alex Fornito
    Melbourne Neuropsychiatry Centre, The University of Melbourne and Melbourne Health, Melbourne, Australia
    Neuroimage 62:2296-314. 2012
    ....
  32. ncbi request reprint A tale of two cities: a neuroimaging investigation of Melbourne-Sydney rivalry comparing cortical thickness in healthy adults
    Dennis Velakoulis
    Melbourne Neuropsychiatry Centre, University of Melbourne, Melbourne, Vic, Australia
    Australas Psychiatry 15:67-71. 2007
    ..We sought to identify neurobiological correlates of Melbourne-Sydney rivalry through neuroimaging measures of a key brain region involved in cognitive and emotional regulation...
  33. pmc Modulation of brain resting-state networks by sad mood induction
    Ben J Harrison
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Victoria, Australia
    PLoS ONE 3:e1794. 2008
    ..While these 'resting-state networks' may be relatively enduring phenomena, other evidence suggest that dynamic changes in their functional connectivity may also emerge depending on the brain state of subjects during scanning...
  34. doi request reprint Voxelwise meta-analysis of gray matter abnormalities in bipolar disorder
    Emre Bora
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne, Melbourne, Victoria, Australia
    Biol Psychiatry 67:1097-105. 2010
    ..We conducted a meta-analysis of gray matter abnormalities in bipolar disorder (BD) using voxel-based morphometry studies to help clarify the structural abnormalities underpinning this condition...
  35. doi request reprint Whole-brain anatomical networks: does the choice of nodes matter?
    Andrew Zalesky
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne, Melbourne, Australia
    Neuroimage 50:970-83. 2010
    ..9 vs. sigma(4000)=53.6+/-2.2). These findings indicate that any comparison of network parameters across studies must be made with reference to the spatial scale of the nodal parcellation...
  36. doi request reprint Pituitary gland volume in currently depressed and remitted depressed patients
    Valentina Lorenzetti
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, VIC Australia
    Psychiatry Res 172:55-60. 2009
    ..In conclusion, PGV does not appear to be a marker of current or past MDD in adult patients...
  37. doi request reprint Gray matter abnormalities in Major Depressive Disorder: a meta-analysis of voxel based morphometry studies
    Emre Bora
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Victoria, Australia
    J Affect Disord 138:9-18. 2012
    ..Here, we aimed to identify those brain regions that most consistently showed gray matter anomalies in MDD, and their clinical correlates, using meta-analytic techniques...
  38. doi request reprint Network-based statistic: identifying differences in brain networks
    Andrew Zalesky
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Australia
    Neuroimage 53:1197-207. 2010
    ....
  39. ncbi request reprint A systematic review of diffusion weighted MRI studies of white matter microstructure in adolescent substance users
    Simon T E Baker
    Turning Point Alcohol and Drug Centre, Eastern Health Clinical School, Monash University and Eastern Health, Victoria, Australia Monash Clinical and Imaging Neuroscience, School of Psychology and Psychiatry and Monash Biomedical Imaging, Monash University, Victoria, Australia Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Victoria, Australia
    Neurosci Biobehav Rev 37:1713-23. 2013
    ....
  40. doi request reprint On the use of correlation as a measure of network connectivity
    Andrew Zalesky
    Melbourne Neuropsychiatry Centre, The University of Melbourne and Melbourne Health, Melbourne, Australia
    Neuroimage 60:2096-106. 2012
    ..g. degree distribution). The main conclusion of this article is that correlation can and should be used to measure connectivity, however appropriate null networks should be used to benchmark network measures in correlation networks...
  41. doi request reprint Connectivity differences in brain networks
    Andrew Zalesky
    Melbourne Neuropsychiatry Centre, The University of Melbourne and Melbourne Health, Melbourne, Australia
    Neuroimage 60:1055-62. 2012
    ..The purpose of this article is to compare the pros and cons of the NBS and SPC, provide some guidelines on their practical use and demonstrate their utility using a case study involving neuroimaging data...
  42. ncbi request reprint State, trait and biochemical influences on human anterior cingulate function
    Murat Yucel
    Melbourne Neuropsychiatry Centre, Australia
    Neuroimage 34:1766-73. 2007
    ..They also highlight the importance of considering enduring personal characteristics when mapping human brain-behavior relationships...
  43. ncbi request reprint A DTI-derived measure of cortico-cortical connectivity
    Andrew Zalesky
    Melbourne Neuropsychiatry Centre, University ofMelbourne, 3053 Carlton South, Australia
    IEEE Trans Med Imaging 28:1023-36. 2009
    ..Finally, we present connectivity maps of some notoriously difficult to track longitudinal and contralateral fasciculi...
  44. pmc Altered striatal functional connectivity in subjects with an at-risk mental state for psychosis
    Orwa Dandash
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne, Melbourne, Australia
    Schizophr Bull 40:904-13. 2014
    ..Together, these results suggest that risk for psychosis is mediated by a complex interplay of alterations in both dorsal and ventral corticostriatal systems. ..
  45. pmc Competitive and cooperative dynamics of large-scale brain functional networks supporting recollection
    Alex Fornito
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Parkville, Victoria 3053, Australia
    Proc Natl Acad Sci U S A 109:12788-93. 2012
    ..Our findings highlight the dynamic, context-dependent nature of large-scale brain dynamics and shed light on their contribution to individual differences in behavior...
  46. pmc Connectomic intermediate phenotypes for psychiatric disorders
    Alex Fornito
    Department of Psychiatry, Melbourne Neuropsychiatry Centre, University of Melbourne and Melbourne Health, Carlton South VIC, Australia
    Front Psychiatry 3:32. 2012
    ..The findings indicate that imaging connectomics provides a powerful framework for understanding how genetic risk for psychiatric disease is expressed through altered structure and function of the human connectome...
  47. doi request reprint Regional brain abnormalities associated with long-term heavy cannabis use
    Murat Yucel
    MAPS, ORYGEN Research Centre, 35 Poplar Rd, Melbourne, Victoria, Australia
    Arch Gen Psychiatry 65:694-701. 2008
    ..Cannabis is the most widely used illicit drug in the developed world. Despite this, there is a paucity of research examining its long-term effect on the human brain...
  48. pmc Prefrontal and amygdala volumes are related to adolescents' affective behaviors during parent-adolescent interactions
    Sarah Whittle
    ORYGEN Research Centre, University of Melbourne, Parkville 3052, Victoria, Australia
    Proc Natl Acad Sci U S A 105:3652-7. 2008
    ..Particularly as adolescence marks a period of rapid brain maturation, our findings have implications for mental health outcomes that may be revealed later along the developmental trajectory...