Affiliation: Western Australia
- Aspirin-resistant thromboxane biosynthesis and the risk of myocardial infarction, stroke, or cardiovascular death in patients at high risk for cardiovascular eventsJohn W Eikelboom
Department of Medicine, University of Western Australia, Thrombosis and Haemophilia Unit, Royal Perth Hospital, Perth, Australia
Circulation 105:1650-5. 2002..We studied whether aspirin resistance, defined as failure of suppression of thromboxane generation, increases the risk of cardiovascular events in a high-risk population...
- Recombinant activated factor VII for the treatment of life-threatening haemorrhageJohn W Eikelboom
Department of Haematology, Royal Perth Hospital and School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia, Australia
Blood Coagul Fibrinolysis 14:713-7. 2003..These uncontrolled data suggest a role for rFVIIa as an adjunctive haemostatic measure in surgical patients with life-threatening haemorrhage for whom conventional measures to achieve haemostasis have failed...
- Thromboprophylaxis practice patterns in two Western Australian teaching hospitalsJohn W Eikelboom
Department of Hematology, Royal Perth Hospital, Wellington Street, Perth, WA, 6001 Australia
Haematologica 89:586-93. 2004..Our objective was to determine what proportion of patients undergoing elective hip or knee arthroplasty actually receive recommended thromboprophylaxis according to international guidelines...
- Failure of aspirin to prevent atherothrombosis: potential mechanisms and implications for clinical practiceJohn W Eikelboom
Department of Haematology, Royal Perth Hospital, Box X2213 GPO, Perth, WA 6001, Australia
Am J Cardiovasc Drugs 4:57-67. 2004....
- Aspirin resistance: a new independent predictor of vascular events?John W Eikelboom
Department of Haematology, Royal Perth Hospital, Wellington Street, Perth, WA 6001, Australia
J Am Coll Cardiol 41:966-8. 2003
- The evolving role of direct thrombin inhibitors in acute coronary syndromesJohn Eikelboom
Department of Medicine, University of Western Australia, Perth, Australia
J Am Coll Cardiol 41:70S-78S. 2003..70; 95% confidence interval, 0.56 to 0.87), with little impact on death. Further evaluation of hirudin and bivalirudin in the antithrombotic management of patients with ACS is warranted...
- Low molecular weight heparins and heparinoidsJohn W Eikelboom
Department of Haematology, Royal Perth Hospital, GPO Box X2213, Perth, WA 6001, Australia
Med J Aust 177:379-83. 2002..The heparinoid danaparoid sodium is effective for the treatment of heparin-induced thrombocytopenia...
- Thrombolysis compared with heparin for the initial treatment of pulmonary embolism: a meta-analysis of the randomized controlled trialsSusan Wan
School of Medicine and Pharmacology, University of Western Australia, Perth, West Australia
Circulation 110:744-9. 2004..Randomized trials and meta-analyses have reached conflicting conclusions about the role of thrombolytic therapy for the treatment of acute pulmonary embolism...
- Endothelial and platelet activation in acute ischemic stroke and its etiological subtypesPaul Cherian
Department of Medicine, University of Western Australia, Perth, Australia
Stroke 34:2132-7. 2003..We also hypothesized that these markers would be differentially elevated in ischemic stroke caused by large- and small-artery atherothrombosis compared with cardiogenic embolism...
- Protein Z in ischemic stroke and its etiologic subtypesAndrew M McQuillan
Department of Hematology, Royal Perth Hospital, Box X2213 GPO, Perth, WA 6897, Australia
Stroke 34:2415-9. 2003..The objectives of this study were to determine the association between protein Z, ischemic stroke, and etiologic subtypes of ischemic stroke...
- Management of patients with acute coronary syndromes: what is the clinical role of direct thrombin inhibitors?John W Eikelboom
Department of Medicine, Thrombosis and Haemophilia Unit, University of Western Australia, Royal Perth Hospital, Australia
Drugs 62:1839-52. 2002....
- Venous thromboembolism in travellers: can we identify those at risk?Andrew D McQuillan
Department of Haematology, Royal Perth Hospital, Perth, Australia, and School of Medicine and Pharmacology, University of Western Australia
Blood Coagul Fibrinolysis 14:671-5. 2003..Whether patients with known risk factors for venous thromboembolism prior to travel should be targeted with specific thromboprophylaxis requires randomized evaluation...
- Adding aspirin to clopidogrel after TIA and ischemic stroke: benefits do not match risksGraeme J Hankey
Stroke Unit, Department of Neurology, Royal Perth Hospital, Perth, Australia
Neurology 64:1117-21. 2005....
- Evaluation of the phospholipid-rich dilute Russell's viper venom assay to monitor oral anticoagulation in patients with lupus anticoagulantJim Thom
Coagulation and Thrombosis Unit, Department of Haematology, Royal Perth Hospital, Perth, Western Australia, Australia
Blood Coagul Fibrinolysis 15:353-7. 2004..60, P < 0.0001) but there was no correlation in the presence of lupus anticoagulant (r = -0.13, P = 0.68). Our results suggest that the prdRVVT is not suitable for monitoring warfarin therapy in patients with lupus anticoagulant...
- Recurrent palmar-plantar erythrodysaesthesia following high-dose cytarabine treatment for acute lymphoblastic leukemiaJulie H Crawford
Royal Perth Hospital, Perth, Western Australia, Australia
Eur J Haematol 69:315-7. 2002....
- Antiplatelet agents in acute coronary syndromesJohn W Eikelboom
Department of Haematology, Royal Perth Hospital and Department of Medicine, University of Western Australia, Crawley, WA, Australia
Semin Vasc Med 3:403-14. 2003....
- Venous thromboembolism: diagnosis and management of deep venous thrombosisWai Khoon Ho
Royal Perth Hospital, Perth, WA
Med J Aust 182:476-81. 2005..The risk of recurrence is highest in people with recurrent unprovoked DVT or chronic predisposing factors (eg, cancer) who require indefinite anticoagulant treatment...
- Is there a role for laboratory testing to identify patients at risk of aspirin treatment failure?Wai Khoon Ho
Centre for Clinical Research Excellence, Department of Neurology and Department of Haematology, Royal Perth Hospital, Australia and School of Medicine and Pharmacology, University of Western Australia, Australia
Blood Coagul Fibrinolysis 15:129-30. 2004
- Venous thromboembolism: diagnosis and management of pulmonary embolismCindy H Lee
Department of Haematology, Royal Perth Hospital, Perth, WA, Australia
Med J Aust 182:569-74. 2005....
- Thromboprophylaxis practice patterns in hip fracture surgery patients: experience in Perth, Western AustraliaSusan Wan
School of Medicine and Pharmacology, University of Western Australia, Royal Perth Hospital, Perth, Western Australia, Australia
ANZ J Surg 73:826-9. 2003..The purpose of the present study was to examine current thromboprophylaxis practice patterns in patients undergoing hip fracture surgery at Royal Perth Hospital...
- Clinical usefulness of plasma homocysteine in vascular diseaseGraeme J Hankey
Department of Neurology, Royal Perth Hospital, Wellington Street, Perth, Western Australia, 6001
Med J Aust 181:314-8. 2004..There is currently insufficient evidence to recommend routine screening and treatment of high tHcy concentrations with folic acid and other vitamins to prevent atherothrombotic vascular disease...
- Risk of recurrent venous thromboembolism in patients with common thrombophilia: a systematic reviewWai Khoon Ho
Department of Haematology, Royal Perth Hospital and Centre for Clinical Research Excellence, University of Western Australia, Perth
Arch Intern Med 166:729-36. 2006..These data call into question the cost-effectiveness of routine testing for these common inherited thrombophilic polymorphisms among patients with a first episode of VTE...
- The incidence of venous thromboembolism: a prospective, community-based study in Perth, Western AustraliaWai Khoon Ho
Department of Haematology, Austin and Repatriation Medical Centre, Melbourne, Vic, Australia
Med J Aust 189:144-7. 2008....
- Antiplatelet drugsGraeme J Hankey
Royal Perth Hospital, 197 Wellington Street, Perth, WA 6001, Australia
Med J Aust 178:568-74. 2003....
- Aspirin resistanceGraeme J Hankey
Department of Neurology, Royal Perth Hospital and School of Medicine and Pharmacology, University of Western Australia, Perth, WA, Australia
Lancet 367:606-17. 2006..Potential mechanisms of aspirin resistance can then be explored and treatments assessed...
- Antithrombotic drugs for patients with ischaemic stroke and transient ischaemic attack to prevent recurrent major vascular eventsGraeme J Hankey
Department of Neurology, Royal Perth Hospital, Australia
Lancet Neurol 9:273-84. 2010..Other new anticoagulants, including the oral factor Xa inhibitors, rivaroxaban, apixaban, and edoxaban, the parenteral factor Xa inhibitor, idrabiotaparinux, and the novel VKA, tecarfarin, are currently being assessed...
- Trends in incidence and prevalence of hospitalization for atrial fibrillation and associated mortality in Western Australia, 1995-2010Tom Briffa
School of Population Health, The University of Western Australia, Crawley, Western Australia, Australia
Int J Cardiol 208:19-25. 2016..Hospitalization for atrial fibrillation (AF) is a large and growing public health problem. We examined current trends in the incidence, prevalence, and associated mortality of first-ever hospitalization for AF...
- The effect of long-term homocysteine-lowering on carotid intima-media thickness and flow-mediated vasodilation in stroke patients: a randomized controlled trial and meta-analysisKathleen Potter
School of Medicine and Pharmacology, University of Western Australia, Perth, Australia
BMC Cardiovasc Disord 8:24. 2008..B-vitamin supplements reduce tHcy and improve endothelial function in short term trials, but the long-term effects of the treatment on vascular structure and function are unknown...
- Cyclooxygenase-2 inhibitors: are they really atherothrombotic, and if not, why not?Graeme J Hankey
Stroke Unit, Department of Neurology, Royal Perth Hospital, Box X2213 GPO, Perth, WA 6001, Australia
Stroke 34:2736-40. 2003....
- Randomized trial comparing 600- with 300-mg loading dose of clopidogrel in patients with non-ST elevation acute coronary syndrome undergoing percutaneous coronary intervention: results of the Platelet Responsiveness to Aspirin and Clopidogrel and TroponinGerald Yong
Royal Perth Hospital, Perth, Western Australia, Australia
Am Heart J 157:60.e1-9. 2009..There is uncertainty about the benefit of a higher loading dose (LD) of clopidogrel in patients with non-ST elevation acute coronary syndrome (NSTEACS) undergoing early percutaneous coronary intervention (PCI)...
- Prevention of coronary heart disease with aspirin and clopidogrel: efficacy, safety, costs and cost-effectivenessWai Khoon Ho
Department of Haematology, Royal Perth Hospital, Perth, Australia
Expert Opin Pharmacother 5:493-503. 2004..g., > 20%/year). The combination of clopidogrel and aspirin should be considered in patients with non-ST-segment elevation acute coronary syndrome or undergoing percutaneous coronary intervention...
- The risk of iatrogenic bleeding in acute coronary syndromes and long-term mortalityMagdalena Sobieraj-Teague
Department of Haematology, Flinders Medical Centre, Adelaide, Australia
Curr Opin Cardiol 23:327-34. 2008....
- Homocysteine or renal impairment: which is the real cardiovascular risk factor?Kathleen Potter
Department of Cardiology, Level 4, A Block, Royal Perth Hospital, Perth WA6847, Australia
Arterioscler Thromb Vasc Biol 28:1158-64. 2008....
- Suboptimal preventive practices in patients with carotid and peripheral vascular occlusive disease in a tertiary referral settingLip Gen Teh
Department of Vascular Surgery, Royal Perth Hospital, Perth, Western Australia, Australia
ANZ J Surg 73:932-7. 2003..This study aims to examine and compare the use of preventive therapy in patients admitted for interventions related to peripheral and carotid atherosclerotic occlusive disease...
- The tissue factor pathway in ischemic strokeMurray J Adams
Western Australian Biomedical Research Institute, School of Biomedical Sciences, Curtin University, Perth, Australia
Blood Coagul Fibrinolysis 17:527-32. 2006....
- Effect of long-term homocysteine reduction with B vitamins on arterial wall inflammation assessed by fluorodeoxyglucose positron emission tomography: a randomised double-blind, placebo-controlled trialKathleen Potter
School of Medicine and Pharmacology, University of Western Australia, W A, Australia
Cerebrovasc Dis 27:259-65. 2009..We used (18)F-fluorodeoxygluose positron emission tomography ((18)F-FDG PET) to investigate whether long-term homocysteine-lowering treatment alters arterial wall inflammation in patients with a history of ischemic stroke...
- Anticoagulation for venous thromboembolismJohn W Eikelboom
BMJ 334:645. 2007
- Latest medical treatment strategies for venous thromboembolismSimon J McRae
The Queen Elizabeth Hospital, Institute of Medical and Veterinary Sciences, Department of Haematology Oncology, 28 Woodville Rd, Woodville 5011, Adelaide, South Australia, Australia
Expert Opin Pharmacother 8:1221-33. 2007....
- Aspirin resistanceHuyen A Tran
Department of Clinical Haematology, Monash Medical Centre, Clayton, Victoria, Australia
Thromb Res 120:337-46. 2007....
- Clinical update on the therapeutic use of clopidogrel: treatment of acute ST-segment elevation myocardial infarction (STEMI)Huyen Tran
Department of Clinical Haematology, Monash Medical Centre, Victoria, Australia
Vasc Health Risk Manag 2:379-87. 2006..Thus, dual antiplatelet therapy with the combination of clopidogrel and aspirin is becoming the new standard of care for the management of patients with STEMI...
- Inherited thrombophilia and pregnancy associated venous thromboembolismWendy Lim
Department of Medicine, McMaster University, St Joseph s Hospital, Canada
BMJ 334:1318-21. 2007
- Beyond unfractionated heparin and warfarin: current and future advancesJack Hirsh
Henderson Research Centre, Hamilton Health Sciences Corporatin, Ontario, Canada
Circulation 116:552-60. 2007
- The effect of pre-operative aspirin on bleeding, transfusion, myocardial infarction, and mortality in coronary artery bypass surgery: a systematic review of randomized and observational studiesJack C J Sun
Division of Cardiac Surgery, Hamilton General Hospital, McMaster University, 237 Barton St E, Hamilton, Ontario, Canada L8L 2X2
Eur Heart J 29:1057-71. 2008..To obtain estimates of the efficacy and safety of pre-operative aspirin in patients undergoing coronary artery bypass grafting (CABG)...
- Antiplatelet therapy for secondary prevention of noncardioembolic ischemic stroke: a critical reviewMARTIN J O'DONNELL
McMaster University, Ontario, Canada
Stroke 39:1638-46. 2008....
- Who is (still) getting HIT?Theodore E Warkentin
Chest 131:1620-2. 2007
- Efficacy and safety of fondaparinux versus enoxaparin in patients with acute coronary syndromes undergoing percutaneous coronary intervention: results from the OASIS-5 trialShamir R Mehta
Department of Medicine, McMaster University and Population Health Research Institute, Hamilton Health Sciences, Hamilton, Ontario, Canada
J Am Coll Cardiol 50:1742-51. 2007..This study reports a prospectively planned analysis of patients with acute coronary syndrome who underwent early percutaneous coronary intervention (PCI) in the OASIS-5 (Fifth Organization to Assess Strategies in Ischemic Syndromes) trial...
- Incomplete inhibition of thromboxane biosynthesis by acetylsalicylic acid: determinants and effect on cardiovascular riskJohn W Eikelboom
McMaster University, Hamilton, Ontario, Canada
Circulation 118:1705-12. 2008....
- Guidelines for the management of acute coronary syndromes 2006John W Eikelboom
Med J Aust 186:101; discussion 101-2. 2007
- Aspirin for the primary prevention of cardiovascular eventsGraeme J Hankey
Med J Aust 177:343-4. 2002
- Editorial comment--Routine thrombophilia testing in stroke patients is unjustifiedGraeme J Hankey
Stroke 34:1826-7. 2003
- Low-molecular-weight heparin compared with intravenous unfractionated heparin for treatment of pulmonary embolism: a meta-analysis of randomized, controlled trialsDaniel J Quinlan
King s College Hospital, London, United Kingdom
Ann Intern Med 140:175-83. 2004..However, for patients who present with pulmonary embolism, the role of low-molecular-weight heparin is uncertain and unfractionated heparin remains widely used...
- Cardiovascular safety of rofecoxib (Vioxx): lessons learned and unanswered questions: we need processes in place to follow up suspicions about serious adverse eventsPaul E Langton
Med J Aust 181:524-5. 2004
- Congestive heart failure complicating non-ST segment elevation acute coronary syndrome: incidence, predictors, and clinical outcomesShamir R Mehta
Department of Medicine, Mc Master University, Hamilton Health Sciences, Hamilton, ON, Canada
Can J Physiol Pharmacol 83:98-103. 2005..Despite this worse prognosis, patients with ACS developing CHF are less likely to be referred for invasive management...
- Long-term management of venous thromboembolism: is there a role for low-intensity warfarin therapy?John W Eikelboom
Med J Aust 179:68-9. 2003..The recently released PREVENT trial provides some answers...
- Short-duration prophylaxis against venous thromboembolism after total hip or knee replacement: a meta-analysis of prospective studies investigating symptomatic outcomesJames D Douketis
Department of Medicine, McMaster University, and St Joseph s Hospital, Hamilton, Ontario, Canada L8N 4A6
Arch Intern Med 162:1465-71. 2002....
- Adjunctive use of direct thrombin inhibitors in patients receiving fibrinolytic therapy for acute myocardial infarctionJohn K French
Cardiovascular Research Unit, Green Lane Hospital, Auckland, New Zealand
Am J Cardiovasc Drugs 4:107-15. 2004..The major benefit of direct thrombin inhibitors appears to be in patients undergoing PCI, particularly after STEMI...
- Cyclooxygenase inhibitors and the antiplatelet effects of aspirinAndrew McQuillan
N Engl J Med 346:1589-90; author reply 1589-90. 2002
- Unfractionated and low-molecular-weight heparin as adjuncts to thrombolysis in aspirin-treated patients with ST-elevation acute myocardial infarction: a meta-analysis of the randomized trialsJohn W Eikelboom
General Division, Hamilton Health Sciences, Hamilton, Ontario, Canada
Circulation 112:3855-67. 2005..There is uncertainty about the role of intravenous unfractionated heparin (UFH) and low-molecular-weight heparin (LMWH) in patients with ST-elevation myocardial infarction (STEMI) treated with aspirin and thrombolysis...
- Aspirin resistanceGraeme J Hankey
BMJ 328:477-9. 2004
- Ximelagatran or warfarin for stroke prevention in patients with atrial fibrillation?Graeme J Hankey
Stroke Unit, Royal Perth Hospital, 197 Wellington Street Perth, Australia 6001
Stroke 35:389-91. 2004
- Meta-analysis: low-molecular-weight heparin and bleeding in patients with severe renal insufficiencyWendy Lim
McMaster University and Hamilton General Hospital, Hamilton, Ontario, Canada
Ann Intern Med 144:673-84. 2006....
- Enoxaparin versus unfractionated heparin in ST-elevation myocardial infarctionPeter Sleight
N Engl J Med 354:2830-1; author reply 2831-2. 2006
- Adverse impact of bleeding on prognosis in patients with acute coronary syndromesJohn W Eikelboom
Thrombosis Service, Hamilton Health Sciences, Hamilton, Ontario, Canada
Circulation 114:774-82. 2006..The use of multiple antithrombotic drugs and aggressive invasive strategies has increased the risk of major bleeding in acute coronary syndrome (ACS) patients. It is not known to what extent bleeding determines clinical outcome...
- Antithrombotic treatment for peripheral arterial diseaseDaniel G Hackam
Division of Clinical Pharmacology and Toxicology, University of Toronto, Toronto, Canada
Heart 93:303-8. 2007..In addition, this disorder is associated with a systemic milieu characterised by ongoing platelet activation and heightened thrombogenesis...
- The beginning of the end of warfarin?John W Eikelboom
Med J Aust 180:549-51. 2004
- Monitoring unfractionated heparin with the aPTT: time for a fresh lookJohn W Eikelboom
Thrombosis Service, Hamilton General Hospital, Hamilton Health Sciences Corporation and McMaster University, Hamilton, Ontario, Canada
Thromb Haemost 96:547-52. 2006..However, currently available unfractionated heparin assays are much more expensive than the aPTT, are not widely available, and their validity has not been adequately assessed in clinical outcome studies...
- Bone marrow biopsy in thrombocytopenic or anticoagulated patientsJohn W Eikelboom
Br J Haematol 129:562-3. 2005
- A replacement for warfarin: the search continuesJohn W Eikelboom
Circulation 116:131-3. 2007
- Management of antiphospholipid antibody syndrome: a systematic reviewWendy Lim
Department of Medicine, McMaster University, Hamilton, Ontario, Canada
JAMA 295:1050-7. 2006..Patients with APS may be at increased risk of recurrent arterial or venous thrombosis or pregnancy loss...
- Will prasugrel supersede clopidogrel for acute coronary syndromes?Graeme J Hankey
Med J Aust 188:381-2. 2008