Research Topics
| Peter R EastwoodSummaryAffiliation: Western Australia Country: Australia Publications
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Publications
How to write research papers and grants: 2011 Asian Pacific Society for Respirology Annual Scientific Meeting Postgraduate SessionPeter R Eastwood
West Australian Sleep Disorders Research Institute, Department of Pulmonary Physiology and Sleep Medicine, Sir Charles Gairdner Hospital, Perth, Western Australia, Australia
Respirology 17:792-801. 2012....
Collapsibility of the upper airway at different concentrations of propofol anesthesiaPeter R Eastwood
West Australian Sleep Disorders Research Institute, Department of Pulmonary Physiology, Sir Charles Gairdner Hospital, and School of Anatomy and Human Biology, University of Western Australia
Anesthesiology 103:470-7. 2005..This study investigated the effect of varying concentrations of propofol on upper airway collapsibility and the mechanisms responsible for it...- Anaerobic metabolism of inspiratory muscles in COPDPeter R Eastwood
Department of Pulmonary Physiology, Sir Charles Gairdner Hospital, Perth, Western Australia, Australia
Respirology 11:32-40. 2006.... - Obstructive Sleep Apnoea: From pathogenesis to treatment: Current controversies and future directionsPeter R Eastwood
West Australian Sleep Disorders Research Institute, Department of Pulmonary Physiology, Sir Charles Gairdner Hospital, Nedlands, WA 6009, Australia
Respirology 15:587-95. 2010.... - High-intensity inspiratory muscle training in COPDK Hill
Dept of Pulmonary Physiology, Sir Charles Gairdner Hospital, Hospital Avenue, Nedlands, Western Australia, 6009 Australia
Eur Respir J 27:1119-28. 2006..In conclusion, high-intensity inspiratory muscle training improves inspiratory muscle function in subjects with moderate-to-severe chronic obstructive pulmonary disease, yielding meaningful reductions in dyspnoea and fatigue... - Modulation of upper and lower esophageal sphincter tone during sleepPeter R Eastwood
Department of Pulmonary Physiology, Sir Charles Gairdner Hospital, Hospital Avenue, Nedlands, WA 6009, Australia
Sleep Med 8:135-43. 2007..This study sought to describe the effects of sleep, respiration and posture on the function of the UES and the LES and the pressure differentials developed across them... 
Treating obstructive sleep apnea with hypoglossal nerve stimulationPeter R Eastwood
Sir Charles Gairdner Hospital, Perth, Australia
Sleep 34:1479-86. 2011..Reduced upper airway muscle activity during sleep is fundamental to obstructive sleep apnea (OSA) pathogenesis. Hypoglossal nerve stimulation (HGNS) counteracts this problem, with potential to reduce OSA severity...- Evaluation of pharyngeal shape and size using anatomical optical coherence tomography in individuals with and without obstructive sleep apnoeaJennifer H Walsh
West Australian Sleep Disorders Research Institute, Sir Charles Gairdner Hospital, Perth, Western Australia, Australia
J Sleep Res 17:230-8. 2008..These findings suggest that it is an abnormality in size rather than shape that is the more important anatomical predictor of OSA... - Effect of body posture on pharyngeal shape and size in adults with and without obstructive sleep apneaJennifer H Walsh
West Australian Sleep Disorders Research Institute, Sir Charles Gairdner Hospital, Nedlands, Western Australia
Sleep 31:1543-9. 2008..This study compared the effect of body posture on upper airway shape and size in individuals with OSA with control subjects matched for age, BMI, and gender... - Applying anatomical optical coherence tomography to quantitative 3D imaging of the lower airwayRobert A McLaughlin
Optical Biomedical Engineering Laboratory, School of Electrical, Electronic and Computer Engineering, University of Western Australia, Crawley, WA 6009, Australia
Opt Express 16:17521-9. 2008..The paper also illustrates the capability of the system to assess the real-time dynamic changes within the airway that occur during respiration... - Influence of head extension, flexion, and rotation on collapsibility of the passive upper airwayJennifer H Walsh
West Australian Sleep Disorders Research Institute, Department of Pulmonary Physiology, Sir Charles Gairdner Hospital, Nedlands, WA, Australia
Sleep 31:1440-7. 2008..To determine the effect of head posture on upper airway collapsibility and site of collapse of the passive human upper airway... - Relationship between upper airway and inspiratory pump muscle force in obstructive sleep apneaKelly L Shepherd
West Australian Sleep Disorders Research Institute, Department of Pulmonary Physiology, Sir Charles Gairdner Hospital, Nedlands, Western Australia 6009, Australia
Chest 130:1757-64. 2006.... - Estimating maximum work rate during incremental cycle ergometry testing from six-minute walk distance in patients with chronic obstructive pulmonary diseaseKylie Hill
Department of Pulmonary Physiology, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia
Arch Phys Med Rehabil 89:1782-7. 2008.... - Evolution of changes in upper airway collapsibility during slow induction of anesthesia with propofolDavid R Hillman
West Australian Sleep Disorders Research Institute, and Department of Pulmonary Physiology, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia 6009
Anesthesiology 111:63-71. 2009..This study assessed how this increase in collapsibility evolves during slow Propofol induction and how it relates to anesthesia-induced changes in upper airway muscle activity and conscious state... - Gastro-oesophageal reflux symptoms are related to the presence and severity of obstructive sleep apnoeaKelly L Shepherd
Department of Pulmonary Physiology, West Australian Sleep Disorders Research Institute, Sir Charles Gairdner Hospital, Nedlands, Australia
J Sleep Res 20:241-9. 2011..This association is independent of other risk factors including age, gender and body mass index, suggesting a causal relationship between OSA and nocturnal reflux... - Feasibility of Applying Real-time Optical Imaging During Bronchoscopic Interventions for Central Airway ObstructionJonathan P Williamson
Departments of Pulmonary Physiology Respiratory Medicine Radiology, Sir Charles Gairdner Hospital School of Anatomy and Human Biology Optical Biomedical Engineering Laboratory, School of Electrical, Electronic and Computer Engineering, The University of Western Australia West Australian Sleep Disorders Research Institute, Perth, Australia
J Bronchology Interv Pulmonol 17:307-16. 2010..This study aims to describe the potential role of real-time aOCT in guiding interventions during CAO procedures... - Variability of human upper airway collapsibility during sleep and the influence of body posture and sleep stageJeremy S L Ong
Centre for Sleep Science, School of Anatomy and Human Biology, University of Western Australia, Australia
J Sleep Res 20:533-7. 2011..When within-subject variability is accounted for, change in body posture from supine to lateral significantly decreases passive pharyngeal collapsibility... - Respiratory gating of anatomical optical coherence tomography images of the human airwayRobert A McLaughlin
Optical Biomedical Engineering Laboratory, School of Electrical, Electronic and Computer Engineering, University of Western Australia, Crawley WA 6009, Australia
Opt Express 17:6568-77. 2009..It is shown that respiratory gating can substantially improve the quality of aOCT images and reveal events and features that are otherwise obscured by blurring... - Dyspnoea in COPD: can inspiratory muscle training help?Kylie Hill
Department of Pulmonary Physiology, Sir Charles Gairdner Hospital, Nedlands, WA 6009, Australia
Aust J Physiother 50:169-80. 2004..This paper describes the origin of dyspnoea in COPD, with particular attention given to the role of inspiratory muscle dysfunction in its genesis and its possible amelioration through inspiratory muscle training... - Physiologic responses to incremental and self-paced exercise in COPD: a comparison of three testsSian E Turner
Physiotherapy Department, Sir Charles Gairdner Hospital, Hospital Avenue, Nedlands, WA, Australia
Chest 126:766-73. 2004..Greater oxygen desaturation was observed during the field walking tests, suggesting that both the ISWT and 6MWT are more sensitive than the CET in detecting exercise-induced hypoxemia and in assessing ambulatory oxygen therapy needs... - Elastic properties of the central airways in obstructive lung diseases measured using anatomical optical coherence tomographyJonathan P Williamson
Department of Pulmonary Physiology, Sir Charles Gairdner Hospital, Perth, Australia
Am J Respir Crit Care Med 183:612-9. 2011..Such knowledge could help elucidate mechanisms of excessive airway narrowing... - Distribution of airway narrowing responses across generations and at branching points, assessed in vitro by anatomical optical coherence tomographyPeter B Noble
Division of Clinical Sciences, Telethon Institute for Child Health Research, Roberts Road, Perth, 6008, Australia
Respir Res 11:9. 2010..Whilst heterogeneity has been detected by previous experimental approaches, its spatial relationship either within or between airways is unknown... - Anesthesia, sleep, and upper airway collapsibilityDavid R Hillman
West Australian Sleep Disorders Research Institute, Department of Pulmonary Physiology, Sir Charles Gairdner Hospital, Nedlands, Perth, Australia
Anesthesiol Clin 28:443-55. 2010..Specific follow-up of suspected cases is needed to ensure that the sleep-related component of the problem receives appropriate care... - Six-minute walk distance in healthy Singaporean adults cannot be predicted using reference equations derived from Caucasian populationsHermione Poh
School of Physiotherapy, Curtin University of Technology, Perth, Western Australia, Australia
Respirology 11:211-6. 2006..The regression equation developed in this study explained 78% of the variance in 6MWD. Published equations derived from Caucasian subjects overestimate 6MWD in Singaporean Chinese... - Obstructive sleep apnoea and anaesthesiaDavid R Hillman
West Australian Sleep Disorders Research Institute and Department of Pulmonary Physiology, Sir Charles Gairdner Hospital, Perth, WA, Australia
Sleep Med Rev 8:459-71. 2004..On the other hand difficulty with airway maintenance during anaesthesia should prompt further investigation for the possibility of OSA... - The effect of learning on ventilatory responses to inspiratory threshold loading in COPDGavin A Sturdy
Department of Pulmonary Physiology, Sir Charles Gairdner Hospital, Nedlands, WA 6009, Australia
Respir Med 98:1-8. 2004..CONCLUSIONS: In contrast to PImax and Pthmax, which changed with successive tests, a single measure of the ratio Pthmax/PImax may present a useful guide to the endurance capacity of the respiratory muscles in patients with COPD... - Inspiratory muscle training for patients with chronic obstructive pulmonary disease: a practical guide for cliniciansKylie Hill
Curtin Health Innovation Research Institute, Curtin University, Perth, Australia
Arch Phys Med Rehabil 91:1466-70. 2010..It is prudent to exclude people at risk of pneumothorax or spontaneous rib fracture. Evaluation of IMT should include measures of PImax, dyspnea, health-related quality of life, and exercise capacity... - Using optical coherence tomography to improve diagnostic and therapeutic bronchoscopyJonathan P Williamson
Department of Pulmonary Physiology, Sir Charles Gairdner Hospital, Nedlands, Perth, WA 6009, Australia
Chest 136:272-6. 2009..The severity of newly diagnosed tracheomalacia was able to be quantified using aOCT imaging (subject 3). aOCT imaging during bronchoscopy allows accurate real-time airway measurements and may assist bronchoscopic assessment... - Heterogeneous activity of the human genioglossus muscle assessed by multiple bipolar fine-wire electrodesPeter R Eastwood
Department of Pulmonary Physiology, Sir Charles Gairdner Hospital, University of Western Australia, Australia 6009
J Appl Physiol 94:1849-58. 2003..We hypothesize that regional differences in density and type of muscle fiber are the most likely sources of heterogeneity in these responses... - Function of the lower esophageal sphincter during and after high-intensity exerciseKathleen J Maddison
Department of Pulmonary Physiology, Sir Charles Gairdner Hospital, University of Western Australia, Nedlands, Australia
Med Sci Sports Exerc 37:1728-33. 2005..05). CONCLUSIONS: High-intensity exercise reduces LES Pb during exercise in asymptomatic individuals. The magnitude of this exercise-induced impairment in LES function is unaffected by ingestion of a sports drink... - Collapsibility of the upper airway during anesthesia with isofluranePeter R Eastwood
West Australian Sleep Disorders Research Institute, Department of Pulmonary Physiology, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia
Anesthesiology 97:786-93. 2002..The unprotected upper airway tends to obstruct during general anesthesia, yet its mechanical properties have not been studied in detail during this condition... - Obstructive sleep apnoea and nocturnal gastroesophageal reflux are common in lung transplant patientsKelly L Shepherd
Department of Pulmonary Physiology, West Australian Sleep Disorders Research Institute, Sir Charles Gairdner Hospital, Nedlands, WA, Australia
Respirology 13:1045-52. 2008..This study investigated the relationship between nocturnal GOR, OSA and BOS in a group of lung transplant patients... - The impact of continuous positive airway pressure on the lower esophageal sphincterKelly L Shepherd
West Australian Sleep Disorders Research Institute, Department of Pulmonary Physiology, Sir Charles Gairdner Hospital, Nedlands, Western Australia 6009, Australia
Am J Physiol Gastrointest Liver Physiol 292:G1200-5. 2007..The findings suggest CPAP may make the LES less susceptible to reflux by increasing Pb and decreasing the duration of LES relaxation... - Volume displaced by diaphragm motion in emphysemaB Singh
Department of Pulmonary Physiology, Sir Charles Gairdner Hospital, University of Western Australia, Nedlands, Western Australia 6009, Australia
J Appl Physiol 91:1913-23. 2001..36 vs. 0.82 +/- 0.80 liters, P < 0.05). We conclude that DeltaVdi can be normal in emphysema because 1) hyperinflation is shared between ribcage and diaphragm, preserving Lap, and 2) the diaphragm remains flat during inspiration... - Managing obstruction of the central airwaysJ P Williamson
Department of Pulmonary Physiology, Sir Charles Gairdner Hospital, Western Australia 6009, Australia
Intern Med J 40:399-410. 2010.... - Quantifying tracheobronchial tree dimensions: methods, limitations and emerging techniquesJ P Williamson
Department of Pulmonary Physiology, Sir Charles Gairdner Hospital, Nedlands, Perth 6009, Australia
Eur Respir J 34:42-55. 2009..This article contributes to this understanding by providing a comprehensive review of current and emerging techniques for quantifying airway dimensions... - Comparison of incremental and constant load tests of inspiratory muscle endurance in COPDK Hill
Department of Pulmonary Physiology, Sir Charles Gairdner Hospital, Hospital Avenue, Nedlands, Western Australia, Australia 6009
Eur Respir J 30:479-86. 2007..However, to attribute changes in these tests to improvements in inspiratory muscle endurance, breathing pattern should be controlled... - The effects of learning on the ventilatory responses to inspiratory threshold loadingP R Eastwood
Department of Pulmonary Physiology, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia
Am J Respir Crit Care Med 158:1190-6. 1998..Measurements from PTL should only be used to assess respiratory muscle performance after allowing time for learning... - Measuring airway dimensions during bronchoscopy using anatomical optical coherence tomographyJ P Williamson
Dept of Pulmonary Physiology, Level 5, G Block, Sir Charles Gairdner Hospital, Perth, Australia
Eur Respir J 35:34-41. 2010..Using aOCT with conventional bronchoscopy allows real-time measurement of airway dimensions and could be useful clinically in settings where knowledge of airway calibre is required... - Six minute walk distance in healthy subjects aged 55-75 yearsBernadine Camarri
School of Physiotherapy, Curtin University of Technology, Perth, Western Australia, Australia
Respir Med 100:658-65. 2006..9% of the variance. CONCLUSIONS: 6MWD in this healthy population-based sample of males and females exceeds values previously reported. Height and FEV(1) were identified as significant independent predictors of 6MWD in this group... - Anatomical optical coherence tomography for long-term, portable, quantitative endoscopyMatthew S Leigh
Optical Biomedical Engineering Laboratory OBEL, School of Electrical, Electronic and Computer Engineering, University of Western Australia, Crawley, W A 6009, Australia
IEEE Trans Biomed Eng 55:1438-46. 2008..Our experiments show that the instrument is capable of imaging subjects during sleep, and that it can record dynamic changes in airway size and shape... - Improvement in aerobic capacity after an exercise program in sporadic inclusion body myositisLiam G Johnson
Centre for Neuromuscular and Neurological Disorders, University of Western Australia, Perth, Western Australia
J Clin Neuromuscul Dis 10:178-84. 2009..The study aimed to investigate the effects of a combined functional and aerobic exercise program on aerobic capacity, muscle strength, and functional mobility in a group of patients with sporadic inclusion body myositis (IBM)... - The effect of interstate travel on the sleep patterns and performance of elite Australian Rules footballersLouise K Richmond
School of Human Movement and Exercise Science, University of Western Australia, Australia
J Sci Med Sport 10:252-8. 2007..05). All other measures of performance were similar at home and away. These results show that prior interstate travel has minimal effect on sleep quality and game performance in elite footballers... - Effect of asbestos-related pleural fibrosis on excursion of the lower chest wall and diaphragmB Singh
Department of Pulmonary Physiology, Sir Charles Gairdner Hospital, Nedlands, Australia
Am J Respir Crit Care Med 160:1507-15. 1999..Reduction in the latter contribution was the main cause of restriction, because the reduction in volume contributed by the diaphragm was partly compensated by flattening of its dome... - Respiratory muscle training: the con argumentK Hill
Department of Pulmonary Physiology, Sir Charles Gairdner Hospital, Nedlands, WA, Australia
Chron Respir Dis 2:223-4. 2005 - Inspiratory muscle performance in endurance athletes and sedentary subjectsP R Eastwood
Department of Pulmonary Physiology, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia
Respirology 6:95-104. 2001..The aim of this study was to determine whether whole-body endurance training is associated with increased respiratory muscle strength and endurance... - Quantitative upper airway imaging with anatomic optical coherence tomographyJulian J Armstrong
Optical Biomedical Engineering Laboratory, School of Electrical, Electronic, and Computer Engineering, University of Western Australia, 35 Stirling Highway, Crawley, Western Australia 6009
Am J Respir Crit Care Med 173:226-33. 2006..We describe an endoscopic optical technique (anatomic optical coherence tomography, aOCT) that provides quantitative real-time imaging of the internal anatomy of the human upper airway... - Effect of surface tension of mucosal lining liquid on upper airway mechanics in anesthetized humansJason P Kirkness
Ludwig Engel Centre for Respiratory Research, Westmead Hospital and University of Sydney, Westmead, New South Wales, 2145, Australia
J Appl Physiol 95:357-63. 2003..Instillation of exogenous surfactant into the UA lowers the gamma of UAL, thus increasing UA patency and augmenting reopening of the collapsed airway... - Comparison of upper airway collapse during general anaesthesia and sleepPeter R Eastwood
Lancet 359:1207-9. 2002..Our findings suggest that sleep-disordered breathing should be considered in all patients with a pronounced tendency for upper airway obstruction during anaesthesia or during recovery from it...