Research Topics
Species | A L JamesSummaryAffiliation: West Australian Sleep Disorders Research Institute Country: Australia Publications
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Detail Information
Publications
What can Busselton population health surveys tell us about asthma in older people?Alan L James
West Australian Sleep Disorders Research Institute Department of Pulmonary Physiology, Queen Elizabeth II Medical Centre, Level 5, G Block, Hospital Avenue, Nedlands, WA 6009, Australia
Med J Aust 183:S17-9. 2005..Measure airway responsiveness and exhaled nitric oxide to detect airway abnormalities in older people and relate this to the diagnoses of asthma and other diseases...- Remodelling of airway smooth muscle in asthma: what sort do you have?A James
West Australian Sleep Disorders Research Institute, School of Medicine and Pharmacology, University of Western Australia, Nedlands, WA, Australia
Clin Exp Allergy 35:703-7. 2005..The outcomes of such studies will be methods of monitoring and of treatment that will be tailored to the sort of smooth muscle modelling that is present in individual cases... - Comparison of sputum induction using inhaled methacholine or hypertonic salineAlan L James
West Australian Sleep Disorders Research Institute, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia
Respirology 10:57-62. 2005..Methacholine is most commonly used to assess airway responsiveness. The aim of this study was to compare sputum induction by methacholine and hypertonic saline challenges, and the subsequent inflammatory cell differential counts... - Airway remodeling in asthmaAlan James
West Australian Sleep Disorders Research Institute, Queen Elizabeth II Medical Centre, School of Medicine and Pharmacology, University of Western Australia, Perth, Australia
Curr Opin Pulm Med 11:1-6. 2005..The aim is to demonstrate how the term remodeling is becoming increasingly less specific as reductionism is applied to this field of study... - Time to death, airway wall inflammation and remodelling in fatal asthmaA L James
West Australian Sleep Disorders Research Institute, Sir Charles Gairdner Hospital, Nedlands, Western Australia 6009, Australia
Eur Respir J 26:429-34. 2005..It suggests that in short course cases acute airway narrowing is due, predominantly, to bronchoconstriction despite higher blood levels of salbutamol. Mucus accumulation may be more important in long course cases... - Clinical relevance of airway remodelling in airway diseasesA L James
West Australian Sleep Disorders Research Institute, Internal mailbox 201, Queen Elizabeth II Medical Centre, Hospital Avenue, Nedlands, Western Australia 6009, Australia
Eur Respir J 30:134-55. 2007..COPD is most often due to smoking where there is also remodelling of the parenchyma that may contribute to symptoms... - Decline in lung function in the Busselton Health Study: the effects of asthma and cigarette smokingAlan L James
West Australian Sleep Disorders Research Institute, Queen Elizabeth II Medical Centre, Nedlands, Australia
Am J Respir Crit Care Med 171:109-14. 2005..Smoking and asthma had additive but not multiplicative effects on decline. Thus, asthma is associated with reduced lung function at the beginning of adult life as well as an increased rate of decline during adult life... - Familial aggregation and heritability of asthma-associated quantitative traits in a population-based sample of nuclear familiesL J Palmer
Genetic Epidemiology Unit, Division of Population Sciences, TVW Telethon Institute for Child Health Research, Perth, Australia
Eur J Hum Genet 8:853-60. 2000..Our study suggests that total and specific serum IgE levels, blood eosinophil counts and airways responsiveness to inhaled agonist are appropriate phenotypes for molecular investigations of the genetic susceptibility to asthma... - Airway smooth muscle thickness in asthma is related to severity but not duration of asthmaA L James
Dept of Pulmonary Physiology, West Australian Sleep Disorders Research Institute, Queen Elizabeth II Medical Centre, Nedlands, WA, Australia
Eur Respir J 34:1040-5. 2009..No effect due to study centre, other than that due to sampling strategy, was found. The thickness of the ASM layer is increased in asthma and is related to the severity of asthma but not its duration... - The PHF11 gene is not associated with asthma or asthma phenotypes in two independent populationsJ McClenaghan
Centre for Genetic Epidemiology and Biostatistics, University of Western Australia, Nedlands, WA, Australia
Thorax 64:620-5. 2009..Initial studies have reported strong associations of variants in the plant homeodomain zinc finger protein 11 (PHF11) gene with serum IgE levels, asthma, airway hyper-responsiveness and childhood atopic dermatitis... - Gibbs sampling-based segregation analysis of asthma-associated quantitative traits in a population-based sample of nuclear familiesL J Palmer
Genetic Epidemiology Unit, Division of Population Sciences, TVW Telethon Institute for Child Health Research, Perth, Western Australia
Genet Epidemiol 20:356-72. 2001..These results have implications for gene discovery programs... - Changes in the prevalence of asthma in adults since 1966: the Busselton health studyA L James
Dept of Pulmonary Physiology West Australian Sleep Disorders Research Institute, Level 5, G Block, Sir Charles Gairdner Hospital, Hospital Avenue, Nedlands, WA 6009, Australia
Eur Respir J 35:273-8. 2010..The lack of changes in AHR and doctor-diagnosed bronchitis suggests that factors such as diagnostic transfer and increased awareness of asthma have also contributed to the rise in prevalence of DDA... - Gastro-oesophageal reflux and respiratory symptoms in Busselton adults: the effects of bodyweight and sleep apnoeaS A Mulrennan
Department of Respiratory Medicine, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia
Intern Med J 42:772-9. 2012..Although a number of epidemiological studies have addressed their relationship, none has investigated the confounding effects of body mass index (BMI) and obstructive sleep apnoea (OSA), both of which are associated with reflux... - AluyMICB dimorphism within the class I region of the major histocompatibility complex is associated with asthma and airflow obstruction in the Busselton populationJ Hui
UWA Centre for Medical Research, Western Australian Institute for Medical Research, The University of Western Australia, and Western Australian Sleep Disorders Research Institute, Sir Charles Gairdner Hospital, Western Australia
Clin Exp Allergy 36:728-34. 2006..Background The highly polymorphic non-classical MHC class I polypeptide-related (MIC) genes, MICA and MICB, encode stress inducible glycoproteins, which are expressed on a variety of epithelial cells, including those of the lungs... - Mortality and airflow obstruction in asthma: a 17-year follow-up studyJ A Panizza
Department of Pulmonary Physiology, Sir Charles Gairdner Hospital, Perth, WA, Australia
Intern Med J 36:773-80. 2006..Symptoms and mortality risk improved in association with increased reported use of inhaled corticosteroids; however, there was ongoing chronic airflow obstruction... - Mast cell densities in bronchial biopsies and small airways are relatedM L Carroll
West Australian Sleep Disorders Research Institute Department of Pulmonary Physiology, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia
J Clin Pathol 64:394-8. 2011..The study sought to determine whether mast cell counts in endobronchial biopsies of large airways are related to mast cell counts in the small airways... - Quantifying tracheobronchial tree dimensions: methods, limitations and emerging techniquesJ P Williamson
Department of Pulmonary Physiology, Sir Charles Gairdner Hospital, Nedlands, Perth 6009, Australia
Eur Respir J 34:42-55. 2009..This article contributes to this understanding by providing a comprehensive review of current and emerging techniques for quantifying airway dimensions... - Informed consent for the study of retained tissues from postmortem examination following sudden infant deathJ G Elliot
West Australian Sleep Disorders Research Institute, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia
J Med Ethics 34:742-6. 2008..To develop an approach for seeking informed consent to examine tissues retained from a previous study of sudden infant death syndrome (SIDS) as part of a study on asthma, and to document responses and participation rate... - Distinctive immunoglobulin E anti-house dust allergen-binding specificities in a tropical Australian Aboriginal communityB J Hales
Division of Molecular Biotechnology, Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, Perth, Australia
Clin Exp Allergy 37:1357-63. 2007..There is evidence that the specificity of the IgE binding in allergy tests can vary for different populations... - Reduced apoptosis of memory T-cells in the inner airway wall of mild and severe asthmaJ P Lamb
Dept of Pulmonary Physiology, Sir Charles Gairdner Hospital, Hospital Avenue, 6009 Nedlands, WA, Australia
Eur Respir J 26:265-70. 2005..It is possible that survival signals may be received before cells migrate into the interstitium of the inner airway wall... - A genome-wide association scan for asthma in a general Australian populationJ Hui
Western Australian Institute for Medical Research and UWA Centre for Medical Research, B Block, QEII Medical Centre, The University of Western Australia, Nedlands, WA, 6009, Australia
Hum Genet 123:297-306. 2008..001). Each region contains a predicted gene that showed strong associations with asthma. Further studies are underway to characterize the novel candidate asthma susceptibility genes identified in this genome-wide study... - Respiratory infections and lung function in an Australian Aboriginal communityA W Bill Musk
Department of Respiratory Medicine, Sir Charles Gairdner Hospital, Nedlands, WA 6009, Australia
Respirology 13:257-62. 2008..To investigate the association between serological evidence of past infections with common respiratory pathogens and lung function in members of an isolated community of Aborigines from tropical coastal north-western Australia... - Abnormalities of the bronchial arteries in asthmaFrancis H Y Green
Respiratory Research Group, University of Calgary, 3330 Hospital Dr NW, Calgary, AB, T2N 4N1, Canada
Chest 130:1025-33. 2006..The bronchial arteries supply systemic blood to the airways, tracheobronchial lymph nodes, and nerves. Their structure has not been studied in patients with asthma... - Airway basement membrane perimeter distensibility and airway smooth muscle area in asthmaAlan L James
Department of Pulmonary Physiology, West Australian Sleep Disorders Research Institute, Perth, Western Australia, Australia
J Appl Physiol 104:1703-8. 2008..We conclude that the effects of inflation on the relationship between Pbm and ASM are small and do not account for the differences observed in ASM between cases of asthma and nonasthmatic controls... - Aggregations of lymphoid cells in the airways of nonsmokers, smokers, and subjects with asthmaJohn G Elliot
Faculty of Regional Professional Studies, Edith Cowan University, Bunbury, WA, Australia
Am J Respir Crit Care Med 169:712-8. 2004..It remains to be determined if IALC contribute to or result from persistent airway inflammation in asthma... - Respiratory morbidity and lung function in two Aboriginal communities in Western AustraliaMarieke W Verheijden
Department of Public Health, University of Western Australia, Perth, Australia
Respirology 7:247-53. 2002..The role of infection requires further investigation. The results suggest that the lower lung function observed in Aboriginal communities (compared with non-Aboriginal communities) results at least partly from environmental factors... - On the terminology for describing the length-force relationship and its changes in airway smooth muscleTony R Bai
James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, University of British Columbia, Vancouver, Canada
J Appl Physiol 97:2029-34. 2004..We also discuss frequently used terms that do not have commonly accepted definitions that should be used cautiously... - Peripheral airways in asthmaAlan L James
Department of Pulmonary Physiology, Sir Charles Gairdner Hospital, Hospital Avenue, Nedlands 6009, Western Australia, Australia
Curr Allergy Asthma Rep 2:166-74. 2002.... - Correlates of habitual snoring and witnessed apnoeas in Busselton, Western AustraliaMatthew W Knuiman
School of Population Health M431, University of Western Australia, 35 Stirling Highway, Crawley, Western Australia 6009
Aust N Z J Public Health 29:412-5. 2005..The aim of this study was to identify potential body size, behavioural and respiratory risk factors for habitual snoring and witnessed apnoeas in a general population... - The relationship of reticular basement membrane thickness to airway wall remodeling in asthmaAlan L James
Department of Pulmonary Physiology, Sir Charles Gairdner Hospital, Nedlands, Western Australia
Am J Respir Crit Care Med 166:1590-5. 2002.... - Genetic variation in immune signaling genes differentially expressed in asthmatic lung tissuesKarine Tremblay
Hopital Laval, Universite Laval, Quebec, Canada
J Allergy Clin Immunol 122:529-36.e17. 2008..Eight genes in the immune signaling pathway shown to be differentially expressed in asthmatic lung biopsy specimens in a previous microarray experiment were selected as candidate genes for asthma susceptibility... - Airway alveolar attachment points and exposure to cigarette smoke in uteroJohn G Elliot
Department of Pulmonary Physiology, Sir Charles Gairdner Hospital, Perth, Western Australia, Australia
Am J Respir Crit Care Med 167:45-9. 2003..These findings suggest that in utero cigarette smoke exposure may result in abnormal airway function due to a reduction of the forces opposing airway narrowing...