Lin Fa Wang

Summary

Country: Australia

Publications

  1. doi request reprint Thank you to Virology Journal's peer reviewers in 2013
    Linfa Wang
    CSIRO Animal Food and Health Sciences, Australian Animal Health Laboratory, Geelong, Vic, 3220, Australia
    Virol J 11:4. 2014
  2. pmc Metagenomic study of the viruses of African straw-coloured fruit bats: detection of a chiropteran poxvirus and isolation of a novel adenovirus
    Kate S Baker
    University of Cambridge, Department of Veterinary Medicine, Madingley Rd, Cambridge, Cambridgeshire, CB3 0ES, United Kingdom
    Virology 441:95-106. 2013
  3. pmc Identification of diverse full-length endogenous betaretroviruses in megabats and microbats
    Joshua A Hayward
    Retroviral Biology and Antivirals Laboratory, Centre for Virology, Burnet Institute, Melbourne, VIC 3004, Australia
    Retrovirology 10:35. 2013
  4. pmc The immune gene repertoire of an important viral reservoir, the Australian black flying fox
    Anthony T Papenfuss
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, VIC 3052, Australia
    BMC Genomics 13:261. 2012
  5. pmc Thank you to Virology Journal's peer reviewers in 2012
    Linfa Wang
    CSIRO Animal Food and Health Sciences, Australian Animal Health Laboratory, Geelong, Vic, 3220, Australia
    Virol J 10:44. 2013
  6. doi request reprint Diagnosis of henipavirus infection: current capabilities and future directions
    Lin Fa Wang
    CSRIO Livestock Industries, Australian Animal Health Laboratory, Geelong, Vic, Australia
    Curr Top Microbiol Immunol 359:179-96. 2012
  7. doi request reprint Mass extinctions, biodiversity and mitochondrial function: are bats 'special' as reservoirs for emerging viruses?
    Lin Fa Wang
    CSRIO Livestock Industries, Australian Animal Health Laboratory, Geelong, Victoria 3216, Australia
    Curr Opin Virol 1:649-57. 2011
  8. pmc Discovery of retroviral homologs in bats: implications for the origin of mammalian gammaretroviruses
    Jie Cui
    Institute of Molecular Ecology and Evolution, East China Normal University, Shanghai, China
    J Virol 86:4288-93. 2012
  9. pmc Identification of a conserved JEV serocomplex B-cell epitope by screening a phage-display peptide library with a mAb generated against West Nile virus capsid protein
    En Cheng Sun
    The Key Laboratory of Veterinary Public Health, Ministry of Agriculture, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150001, PR China
    Virol J 8:100. 2011
  10. pmc Inhibition of Henipavirus fusion and infection by heptad-derived peptides of the Nipah virus fusion glycoprotein
    Katharine N Bossart
    Department of Microbiology and Immunology, Uniformed Services University, Bethesda, MD 20814, USA
    Virol J 2:57. 2005

Detail Information

Publications99

  1. doi request reprint Thank you to Virology Journal's peer reviewers in 2013
    Linfa Wang
    CSIRO Animal Food and Health Sciences, Australian Animal Health Laboratory, Geelong, Vic, 3220, Australia
    Virol J 11:4. 2014
    ..This is a great achievement by any standard. We look forward to your continuous support of Virology Journal either as an invited reviewer or a contributing author in the years to come. ..
  2. pmc Metagenomic study of the viruses of African straw-coloured fruit bats: detection of a chiropteran poxvirus and isolation of a novel adenovirus
    Kate S Baker
    University of Cambridge, Department of Veterinary Medicine, Madingley Rd, Cambridge, Cambridgeshire, CB3 0ES, United Kingdom
    Virology 441:95-106. 2013
    ..In sum, E. helvum display a wide variety of mammalian viruses, some of them genetically similar to known human pathogens, highlighting the possibility of zoonotic transmission...
  3. pmc Identification of diverse full-length endogenous betaretroviruses in megabats and microbats
    Joshua A Hayward
    Retroviral Biology and Antivirals Laboratory, Centre for Virology, Burnet Institute, Melbourne, VIC 3004, Australia
    Retrovirology 10:35. 2013
    ..To improve our understanding of betaretroviruses in an evolutionarily distinct host species, we characterized βERVs present in the genomes and transcriptomes of mega- and microbats, which are an important reservoir of emerging viruses...
  4. pmc The immune gene repertoire of an important viral reservoir, the Australian black flying fox
    Anthony T Papenfuss
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, VIC 3052, Australia
    BMC Genomics 13:261. 2012
    ..In this study, we describe the immune transcriptome of the Australian flying fox, Pteropus alecto, providing an important resource for identification of genes involved in a range of activities including antiviral immunity...
  5. pmc Thank you to Virology Journal's peer reviewers in 2012
    Linfa Wang
    CSIRO Animal Food and Health Sciences, Australian Animal Health Laboratory, Geelong, Vic, 3220, Australia
    Virol J 10:44. 2013
    ..We look forward to your continuous support to this journal either as an invited reviewer or a contributing author in the years to come...
  6. doi request reprint Diagnosis of henipavirus infection: current capabilities and future directions
    Lin Fa Wang
    CSRIO Livestock Industries, Australian Animal Health Laboratory, Geelong, Vic, Australia
    Curr Top Microbiol Immunol 359:179-96. 2012
    ..In addition to provide an updated review of the current test capabilities, this review also identifies key future challenges in henipavirus diagnosis...
  7. doi request reprint Mass extinctions, biodiversity and mitochondrial function: are bats 'special' as reservoirs for emerging viruses?
    Lin Fa Wang
    CSRIO Livestock Industries, Australian Animal Health Laboratory, Geelong, Victoria 3216, Australia
    Curr Opin Virol 1:649-57. 2011
    ....
  8. pmc Discovery of retroviral homologs in bats: implications for the origin of mammalian gammaretroviruses
    Jie Cui
    Institute of Molecular Ecology and Evolution, East China Normal University, Shanghai, China
    J Virol 86:4288-93. 2012
    ..Taken together, these data provide new insights into the origin of the mammalian gammaretroviruses...
  9. pmc Identification of a conserved JEV serocomplex B-cell epitope by screening a phage-display peptide library with a mAb generated against West Nile virus capsid protein
    En Cheng Sun
    The Key Laboratory of Veterinary Public Health, Ministry of Agriculture, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150001, PR China
    Virol J 8:100. 2011
    ..The antigenic sites on C protein that are targeted by humoral immune responses have not been studied thoroughly, and well-defined B-cell epitopes on the WNV C protein have not been reported...
  10. pmc Inhibition of Henipavirus fusion and infection by heptad-derived peptides of the Nipah virus fusion glycoprotein
    Katharine N Bossart
    Department of Microbiology and Immunology, Uniformed Services University, Bethesda, MD 20814, USA
    Virol J 2:57. 2005
    ..Here, we have evaluated these peptides as well as the corresponding scrambled peptide controls in Nipah virus and Hendra virus-mediated membrane fusion and against infection by live virus in vitro...
  11. pmc The YPLGVG sequence of the Nipah virus matrix protein is required for budding
    Jared R Patch
    Department of Microbiology and Immunology, Uniformed Services University, Bethesda, Maryland 20814, USA
    Virol J 5:137. 2008
    ..Here, we have used this system to further explore the budding process by analyzing elements within the M protein that are critical for particle release...
  12. pmc Quantitative analysis of Nipah virus proteins released as virus-like particles reveals central role for the matrix protein
    Jared R Patch
    Department of Microbiology and Immunology, Uniformed Services University, Bethesda, Maryland 20814, USA
    Virol J 4:1. 2007
    ..Here, we have established recombinant expression systems to study NiV particle assembly and budding through the formation of virus-like particles (VLPs)...
  13. pmc Identification of two linear B-cell epitopes from West Nile virus NS1 by screening a phage-displayed random peptide library
    En Cheng Sun
    The Key Laboratory of Veterinary Public Health, Ministry of Agriculture, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, 427 Maduan Street, Nangang District, Harbin 150001, PR China
    BMC Microbiol 11:160. 2011
    ..Although previous work has demonstrated the vital role of WNV NS1-specific antibody responses, the specific epitopes in the NS1 have not been identified...
  14. pmc Differential stepwise evolution of SARS coronavirus functional proteins in different host species
    Xianchun Tang
    School of Life Science, East China Normal University, Shanghai, 200062, PR China
    BMC Evol Biol 9:52. 2009
    ..Previous studies revealed that the spike (S) protein of SARS had experienced adaptive evolution, but whether other functional proteins of SARS have undergone adaptive evolution is not known...
  15. ncbi request reprint Epitope identification and discovery using phage display libraries: applications in vaccine development and diagnostics
    Lin Fa Wang
    CSIRO Livestock Industries, Australian Animal Health Laboratory, Geelong 3220, Victoria, Australia
    Curr Drug Targets 5:1-15. 2004
    ..Instead, this review aims to focus on specific applications related to the discovery and identification of epitopes which have potential as vaccine candidates or can be used in disease diagnosis...
  16. ncbi request reprint Bats, civets and the emergence of SARS
    L F Wang
    CSIRO Livestock Industries, Australian Animal Health Laboratory, Geelong, Victoria, 3220 Australia
    Curr Top Microbiol Immunol 315:325-44. 2007
    ....
  17. pmc Review of bats and SARS
    Lin Fa Wang
    Australian Animal Health Laboratory, Geelong, Victoria, Australia
    Emerg Infect Dis 12:1834-40. 2006
    ..The discovery of bat SARS-like coronaviruses and the great genetic diversity of coronaviruses in bats have shed new light on the origin and transmission of SARS coronaviruses...
  18. doi request reprint Discovering novel zoonotic viruses
    Lin Fa Wang
    CSIRO Livestock Industries, Australian Animal Health Laboratory
    N S W Public Health Bull 22:113-7. 2011
    ....
  19. ncbi request reprint Full-length genome sequence and genetic relationship of two paramyxoviruses isolated from bat and pigs in the Americas
    L F Wang
    CSIRO Livestock Industries, Australian Animal Health Laboratory, Geelong, Vic, Australia
    Arch Virol 152:1259-71. 2007
    ..Based on these findings, we hypothesise that PoRV may also originate from bats, and spillover events from bats to pigs, either directly or via an intermediate host, were responsible for the sporadic disease outbreaks observed in Mexico...
  20. ncbi request reprint Neutralization assays for differential henipavirus serology using Bio-Plex protein array systems
    Katharine N Bossart
    CSIRO Livestock Industries, Australian Animal Health Laboratory, 5 Portarlington Road, Geelong, VIC 3220, Australia
    J Virol Methods 142:29-40. 2007
    ..Sera from henipavirus-seropositive animals differentially blocked ephrin-B2 binding, suggesting that detection and differentiation of HeV and NiV neutralizing antibodies can be done simultaneously in the absence of live virus...
  21. pmc Experimental infection of horses with Hendra virus/Australia/horse/2008/Redlands
    Glenn A Marsh
    Commonwealth Scientific and Industrial Research Organization Livestock Industries, Geelong, Victoria, Australia
    Emerg Infect Dis 17:2232-8. 2011
    ..Our data suggest that a critical factor for reducing HeV exposure risk to humans includes early consideration of HeV in the differential diagnosis and institution of appropriate infection control procedures...
  22. ncbi request reprint Production and application of recombinant antibodies to foot-and-mouth disease virus non-structural protein 3ABC
    Adam J Foord
    CSIRO Livestock Industries, Australian Animal Health Laboratory, PO Bag 24, Geelong, Victoria, Australia
    J Immunol Methods 321:142-51. 2007
    ..To our knowledge, this is the first FMDV DIVA test that uses both recombinant antibody and antigen derived from bacterial expression systems...
  23. pmc Type III IFNs in pteropid bats: differential expression patterns provide evidence for distinct roles in antiviral immunity
    Peng Zhou
    Commonwealth Scientific and Industrial Research Organization Livestock Industries, Australian Animal Health Laboratory, Geelong, Victoria 3220, Australia
    J Immunol 186:3138-47. 2011
    ..These results may have important implications for the role of type III IFNs in the ability of bats to coexist with viruses...
  24. pmc Vaccination of ferrets with a recombinant G glycoprotein subunit vaccine provides protection against Nipah virus disease for over 12 months
    Jackie A Pallister
    CSIRO Livestock Industries, Australian Animal Health Laboratory, 5 Portarlington Road, Geelong, VIC 3220, Australia
    Virol J 10:237. 2013
    ..Since NiV was first identified in 1999, outbreaks have continued to occur in humans in Bangladesh and India on an almost annual basis with case fatality rates reported between 40% and 100%...
  25. pmc Cedar virus: a novel Henipavirus isolated from Australian bats
    Glenn A Marsh
    CSIRO Livestock Industries, Australian Animal Health Laboratory, Geelong, Australia
    PLoS Pathog 8:e1002836. 2012
    ..Preliminary study indicated that CedPV infection of human cells induces a more robust IFN-β response than HeV...
  26. doi request reprint Improvement of a recombinant antibody-based serological assay for foot-and-mouth disease virus
    Janine D Muller
    CSIRO Livestock Industries, Australian Animal Health Laboratory and Australian Biosecurity Cooperative Research Centre, Geelong, Victoria, Australia
    J Immunol Methods 352:81-8. 2010
    ..These modifications have further improved the DIVA test, providing great potential for large scale production and uptake due to its simplicity, reproducibility and low cost...
  27. pmc Recombinant Hendra viruses expressing a reporter gene retain pathogenicity in ferrets
    Glenn A Marsh
    CSIRO Animal, Food and Health Sciences, Australian Animal Health Laboratory, Geelong, VIC 3220, Australia
    Virol J 10:95. 2013
    ..Hendra virus (HeV) is an Australian bat-borne zoonotic paramyxovirus that repeatedly spills-over to horses causing fatal disease. Human cases have all been associated with close contact with infected horses...
  28. pmc A recombinant Hendra virus G glycoprotein-based subunit vaccine protects ferrets from lethal Hendra virus challenge
    Jackie Pallister
    CSIRO Livestock Industries, Australian Animal Health Laboratory, 5 Portarlington Road, Geelong, VIC 3220, Australia
    Vaccine 29:5623-30. 2011
    ..Together, our findings indicate that 100 μg or 20 μg doses of HeVsG vaccine can completely prevent a productive HeV infection in the ferret, suggesting that vaccination to prevent the infection and shedding of HeV is possible...
  29. pmc A neutralizing human monoclonal antibody protects against lethal disease in a new ferret model of acute nipah virus infection
    Katharine N Bossart
    CSIRO Livestock Industries, Australian Animal Health Laboratory, Geelong, Victoria, Australia
    PLoS Pathog 5:e1000642. 2009
    ..This study is the first successful post-exposure passive antibody therapy for Nipah virus using a human monoclonal antibody...
  30. doi request reprint Determination and application of immunodominant regions of SARS coronavirus spike and nucleocapsid proteins recognized by sera from different animal species
    Meng Yu
    CSIRO Livestock Industries, Australian Animal Health Laboratory, Geelong, Victoria, Australia
    J Immunol Methods 331:1-12. 2008
    ..Considering that a large number of animal species are known to be susceptible to SARS-CoV, these assays will be a useful tool to trace the origin and transmission of SARS-CoV and to minimise the risk of animal-to-human transmission...
  31. doi request reprint Ebola Reston virus infection of pigs: clinical significance and transmission potential
    Glenn A Marsh
    Australian Animal Health Laboratory, Livestock Industries, Commonwealth Scientific and Industrial Research Organisation CSIRO, Geelong, Australia
    J Infect Dis 204:S804-9. 2011
    ..These observations confirm not only that asymptomatic infection of pigs with REBOV occurs, but that animals so affected pose a transmission risk to farm, veterinary, and abattoir workers...
  32. ncbi request reprint A rapid immune plaque assay for the detection of Hendra and Nipah viruses and anti-virus antibodies
    Gary Crameri
    CSIRO, Australian Animal Health Laboratory, Private Bag 24, VIC 3220, Geelong, Australia
    J Virol Methods 99:41-51. 2002
    ....
  33. doi request reprint Bats and their virome: an important source of emerging viruses capable of infecting humans
    Ina Smith
    CSIRO Australian Animal Health Laboratory, Geelong, Victoria 3220, Australia
    Curr Opin Virol 3:84-91. 2013
    ....
  34. doi request reprint Evidence of bat origin for Menangle virus, a zoonotic paramyxovirus first isolated from diseased pigs
    Jennifer A Barr
    CSIRO Australian Animal Health Laboratory, Geelong, Victoria 3219, Australia
    J Gen Virol 93:2590-4. 2012
    ..The nucleotide sequence of the bat isolate is 94 % identical to the pig isolate. This finding provides strong evidence supporting the hypothesis that the MenPV outbreak in pigs originated from viruses in bats roosting near the piggery...
  35. pmc A novel bat herpesvirus encodes homologues of major histocompatibility complex classes I and II, C-type lectin, and a unique family of immune-related genes
    Huajun Zhang
    CSIRO Livestock Industries, Australian Animal Health Laboratory, Geelong, Victoria, Australia
    J Virol 86:8014-30. 2012
    ..To our knowledge, MsHV is the first virus genome known to encode MHC class II homologues...
  36. pmc Establishment, immortalisation and characterisation of pteropid bat cell lines
    Gary Crameri
    CSIRO Livestock Industries, Australian Animal Health Laboratory, Geelong, Australia
    PLoS ONE 4:e8266. 2009
    ..New stable bat cell lines are needed to help with these investigations and as tools to assist in the study of bat immunology and virus-host interactions...
  37. doi request reprint Broome virus, a new fusogenic Orthoreovirus species isolated from an Australian fruit bat
    Claudia M Thalmann
    CSIRO Livestock Industries, Australian Animal Health Laboratory, Geelong, Victoria, Australia
    Virology 402:26-40. 2010
    ....
  38. doi request reprint Bat Mx1 and Oas1, but not Pkr are highly induced by bat interferon and viral infection
    Peng Zhou
    CSIRO Australian Animal Health Laboratory, Geelong, Victoria 3220, Australia
    Dev Comp Immunol 40:240-7. 2013
    ..Our results have important implications for the different roles of ISGs in bats and provide the first step in understanding the role of these molecules in the ability of bats to coexist with viruses...
  39. ncbi request reprint Full-length genome sequence of Mossman virus, a novel paramyxovirus isolated from rodents in Australia
    Philippa J Miller
    CSIRO Livestock Industries, Australian Animal Health Laboratory, Private Bag 24, Geelong, Victoria 3220, Australia
    Virology 317:330-44. 2003
    ....
  40. pmc A new model for Hendra virus encephalitis in the mouse
    Johanna Dups
    CSIRO Livestock Industries, Australian Animal Health Laboratory, Geelong, Australia
    PLoS ONE 7:e40308. 2012
    ....
  41. pmc Genome sequence conservation of Hendra virus isolates during spillover to horses, Australia
    Glenn A Marsh
    Australian Animal Health Laboratory, Geelong, Victoria, Australia
    Emerg Infect Dis 16:1767-9. 2010
    ..Our sequencing of 5 isolates from recent Hendra virus outbreaks in horses found no correlation between sequences and time or geographic location of outbreaks...
  42. pmc Interferon production and signaling pathways are antagonized during henipavirus infection of fruit bat cell lines
    Elena R Virtue
    Australian Animal Health Laboratory, CSIRO Livestock Industries, Geelong, Australia
    PLoS ONE 6:e22488. 2011
    ..This is the first report of henipavirus infection in bat cells specifically investigating aspects of the innate immune system...
  43. pmc Chloroquine administration does not prevent Nipah virus infection and disease in ferrets
    Jackie Pallister
    CSIRO Livestock Industries, Australian Animal Health Laboratory, Geelong, Victoria 3220, Australia
    J Virol 83:11979-82. 2009
    ..Chloroquine was assessed using a ferret model of lethal Nipah virus infection and found to be ineffective against Nipah virus infection in vivo...
  44. ncbi request reprint Hendra and Nipah viruses: different and dangerous
    Bryan T Eaton
    Australian Animal Health Laboratory, Commonwealth Scientific and Industrial Research Organization, 5 Portarlington Road, Geelong, Victoria 3220, Australia
    Nat Rev Microbiol 4:23-35. 2006
    ....
  45. ncbi request reprint Location of, immunogenicity of and relationships between neutralization epitopes on the attachment protein (G) of Hendra virus
    John R White
    CSIRO Division of Livestock Industries, Australian Animal Health Laboratory, Geelong, VIC 3220, Australia
    J Gen Virol 86:2839-48. 2005
    ..The latter epitope corresponded to immunodominant neutralization sites found in Rinderpest virus and Measles virus...
  46. pmc Type III IFN receptor expression and functional characterisation in the pteropid bat, Pteropus alecto
    Peng Zhou
    Australian Animal Health Laboratory, CSIRO Livestock Industries, Geelong, Victoria, Australia
    PLoS ONE 6:e25385. 2011
    ..To our knowledge, this report represents the first description of an IFN receptor in any species of bat. The responsiveness of bat cells to IFN-λ support a role for the type III IFN system by epithelial and immune cells in bats...
  47. doi request reprint Expression of novel genes encoded by the paramyxovirus J virus
    Philippa J M Jack
    CSIRO Livestock Industries, Australian Animal Health Laboratory, Private Bag 24 Geelong, Victoria 3220, Australia
    J Gen Virol 89:1434-41. 2008
    ..Preliminary studies indicate that the novel TM protein is a type II glycosylated integral membrane protein, orientated with its C terminus exposed at the cell surface...
  48. ncbi request reprint Genetic analysis of J-virus and Beilong virus using minireplicons
    Danielle E Magoffin
    CSIRO Livestock Industries, CSIRO Australian Animal Health Laboratory, PO Bag 24, Geelong, Victoria 3220, Australia
    Virology 364:103-11. 2007
    ..In addition, the minireplicons were also used to demonstrate that these large-genome viruses also comply with the 'rule of six' and that over-expression of the C protein has a detrimental effect on minigenome replication...
  49. pmc The complete genome sequence of J virus reveals a unique genome structure in the family Paramyxoviridae
    Philippa J M Jack
    CSIRO Livestock Industries, Australian Animal Health Laboratory, Private Bag 24, Geelong, Victoria 3220, Australia
    J Virol 79:10690-700. 2005
    ....
  50. ncbi request reprint Hendra and Nipah viruses: pathogenesis and therapeutics
    Bryan T Eaton
    Australian Animal Health Laboratory, CSIRO, 5 Portarlington Road, Geelong, Victoria 3220, Australia
    Curr Mol Med 5:805-16. 2005
    ....
  51. ncbi request reprint Functional studies of host-specific ephrin-B ligands as Henipavirus receptors
    Katharine N Bossart
    CSIRO Livestock Industries, Australian Animal Health Laboratory, Geelong, Victoria 3220, Australia
    Virology 372:357-71. 2008
    ....
  52. doi request reprint Cloning, expression and antiviral activity of IFNγ from the Australian fruit bat, Pteropus alecto
    Vijaya Janardhana
    CSIRO Livestock Industries, Australian Animal Health Laboratory, P O Bag 24, Geelong, VIC 3220, Australia
    Dev Comp Immunol 36:610-8. 2012
    ..alecto cells. These results provide the first evidence for an antiviral role for bat IFNγin vitro in addition to the application of important immunological reagents for further studies of bat antiviral immunity...
  53. pmc Immunoglobulin heavy chain diversity in Pteropid bats: evidence for a diverse and highly specific antigen binding repertoire
    Michelle L Baker
    CSIRO Livestock Industries, Australian Animal Health Laboratory, PO Bag 24, Geelong, Victoria, 3220, Australia
    Immunogenetics 62:173-84. 2010
    ....
  54. doi request reprint Identification of key amino acid residues required for horseshoe bat angiotensin-I converting enzyme 2 to function as a receptor for severe acute respiratory syndrome coronavirus
    Meng Yu
    CSIRO Livestock Industries, Australian Animal Health Laboratory, Geelong, Victoria 3220, Australia
    J Gen Virol 91:1708-12. 2010
    ....
  55. doi request reprint Studying immunity to zoonotic diseases in the natural host - keeping it real
    Andrew G D Bean
    CSIRO Biosecurity Flagship, Australian Animal Health Laboratory, Geelong, Victoria 3220, Australia
    Nat Rev Immunol 13:851-61. 2013
    ..Such studies will not only lead to a greater understanding of how these infections induce variable disease and immune responses in distinct species but also offer important insights into the evolution of mammalian immune systems. ..
  56. doi request reprint Molecular characterisation of RIG-I-like helicases in the black flying fox, Pteropus alecto
    Christopher Cowled
    CSIRO Livestock Industries, Australian Animal Health Laboratory, 5 Portarlington Rd, East Geelong, Victoria 3220, Australia
    Dev Comp Immunol 36:657-64. 2012
    ..alecto. This study provides the foundation for further investigations into the interactions between bat RIG-I-like helicases and viruses to elucidate the mechanisms responsible for the asymptomatic nature of viral infections in bats...
  57. doi request reprint Epitope mapping using phage-display random fragment libraries
    Lin Fa Wang
    CSIRO Livestock Industries, Australian Animal Health Laboratory, PO Bag 24, Geelong, Victoria, 3220, Australia
    Methods Mol Biol 524:315-32. 2009
    ..In this chapter, we describe the mapping of linear and conformational epitopes of the major African swine fever virus capsid protein using monoclonal as well as polyclonal antibodies...
  58. doi request reprint Hendra and Nipah viruses: why are they so deadly?
    Glenn A Marsh
    CSIRO Livestock Industries, Australian Animal Health Laboratory, Geelong, Victoria 3220, Australia
    Curr Opin Virol 2:242-7. 2012
    ..Our recent study on the mechanism of IFN antagonism by henipaviruses indicated that a better understanding of the virus-host interaction provides great potential to develop new therapeutic strategies against these viruses...
  59. pmc Interferon signaling remains functional during henipavirus infection of human cell lines
    Elena R Virtue
    CSIRO Livestock Industries, Australian Animal Health Laboratory, P O Bag 24, Geelong, Victoria 3220, Australia
    J Virol 85:4031-4. 2011
    ..In contrast to published transfection studies, our study found that the interferon signaling pathways are only partially blocked by henipavirus infection of human cell lines...
  60. ncbi request reprint Peptide mimotopes of phomopsins: identification, characterization and application in an immunoassay
    Meng Yu
    CSIRO Livestock Industries, Australian Animal Health Laboratory, Geelong, Victoria 3220, Australia
    Mol Divers 9:233-40. 2005
    ....
  61. pmc Promotion of Hendra virus replication by microRNA 146a
    Cameron R Stewart
    CSIRO Australian Animal Health Laboratory, Geelong, Victoria, Australia
    J Virol 87:3782-91. 2013
    ..These studies are the first to demonstrate a host miRNA response to Hendra virus infection and suggest an important role for host miRNAs in Hendra virus disease...
  62. doi request reprint Rapid detection of hendra virus using magnetic particles and quantum dots
    Fabio Lisi
    CSIRO, Division of Materials Science and Engineering and Process Science and Engineering, Private Bag 33, Clayton South MDC, 3169, Victoria, Australia
    Adv Healthc Mater 1:631-4. 2012
    ..This method should be applicable for the early detection of any other virus by targeting the specific virus with the corresponding antibody...
  63. pmc Identifying Hendra virus diversity in pteropid bats
    Ina Smith
    Australian Animal Health Laboratory, CSIRO Livestock Industries, East Geelong, Victoria, Australia
    PLoS ONE 6:e25275. 2011
    ..Thus future spillover events are likely to occur, and there is an on-going need for effective risk management strategies for both human and animal health...
  64. doi request reprint Serotype-independent detection of foot-and-mouth disease virus
    Janine D Muller
    CSIRO Livestock Industries, Australian Animal Health Laboratory, 5 Portarlington Road, Geelong, Victoria 3220, Australia
    J Virol Methods 151:146-53. 2008
    ....
  65. doi request reprint A recombinant subunit vaccine formulation protects against lethal Nipah virus challenge in cats
    Jennifer A McEachern
    CSIRO Livestock Industries, Australian Animal Health Laboratory, 5 Portarlington Road, Geelong, Victoria 3220, Australia
    Vaccine 26:3842-52. 2008
    ..The ability to elicit protective systemic and mucosal immunity in this animal model provides significant progress towards the development of a human subunit vaccine against henipaviruses...
  66. doi request reprint Molecular characterisation of Toll-like receptors in the black flying fox Pteropus alecto
    Christopher Cowled
    CSIRO Livestock Industries, Australian Animal Health Laboratory, 5 Portarlington Rd, East Geelong, Victoria 3220, Australia
    Dev Comp Immunol 35:7-18. 2011
    ..This prototype data can now be used to design functional studies of the bat innate immune system...
  67. doi request reprint Molecular characterisation of Australasian isolates of aquatic birnaviruses
    Kelly R Davies
    CSIRO Livestock Industries, Australian Animal Health Laboratory, Private Bag 24, Geelong, Victoria 3220, Australia
    Dis Aquat Organ 93:1-15. 2010
    ....
  68. doi request reprint Epitope mapping using homolog-scanning mutagenesis
    Lin Fa Wang
    CSIRO Livestock Industries, Australian Animal Health Laboratory, PO Bag 24, Geelong, Victoria 3220, Australia
    Methods Mol Biol 524:289-303. 2009
    ..Determination of antibody-binding sites using serial chimeric proteins of different homologs, a technique termed homolog-scanning mutagenesis (HSM), has proven to be especially useful in mapping conformational epitopes...
  69. doi request reprint Paramyxoviruses infecting humans: the old, the new and the unknown
    Elena R Virtue
    CSIRO Livestock Industries, Australian Animal Health Laboratory AAHL, Geelong, Vic, Australia
    Future Microbiol 4:537-54. 2009
    ....
  70. ncbi request reprint Identification of dominant epitopes of synthetic immunocontraceptive vaccines that induce antibodies in dogs
    Meng Yu
    CSIRO Livestock Industries, Australian Animal Health Laboratory, Private Bag 24, Geelong, Victoria 3220, Australia
    Vaccine 23:4589-97. 2005
    ..The approach has utility in the definition of immunodominant epitopes, which may "decoy" antibody responses away from other epitopes, which may be more useful in prophylaxis or therapy...
  71. pmc Membrane fusion tropism and heterotypic functional activities of the Nipah virus and Hendra virus envelope glycoproteins
    Katharine N Bossart
    Department of Microbiology and Immunology, Uniformed Services University, Bethesda, Maryland 20814, USA
    J Virol 76:11186-98. 2002
    ..However, no heterotypic activity was observed with envelope glycoproteins of the morbilliviruses Measles virus and Canine distemper virus...
  72. pmc Potent neutralization of Hendra and Nipah viruses by human monoclonal antibodies
    Zhongyu Zhu
    CCRNP, CCR, NCI Frederick, NIH, Frederick, MD 21702, USA
    J Virol 80:891-9. 2006
    ....
  73. pmc Potent cross-reactive neutralization of SARS coronavirus isolates by human monoclonal antibodies
    Zhongyu Zhu
    Protein Interactions Group, Center for Cancer Research Nanobiology Program, SAIC Frederick, Inc, National Cancer Institute Frederick, National Institutes of Health, Frederick, MD 21702, USA
    Proc Natl Acad Sci U S A 104:12123-8. 2007
    ..These antibodies exhibit cross-reactivity against isolates from the two SARS outbreaks and palm civets and could have potential applications for diagnosis, prophylaxis, and treatment of SARS-CoV infections...
  74. ncbi request reprint Beilong virus, a novel paramyxovirus with the largest genome of non-segmented negative-stranded RNA viruses
    Zhuo Li
    Renal Division and Institute of Nephrology, Peking University First Hospital, Beijing, China
    Virology 346:219-28. 2006
    ....
  75. ncbi request reprint Bats are natural reservoirs of SARS-like coronaviruses
    Wendong Li
    Institute of Zoology, Chinese Academy of Sciences CAS, Beijing, China
    Science 310:676-9. 2005
    ..The human and civet isolates of SARS-CoV nestle phylogenetically within the spectrum of SL-CoVs, indicating that the virus responsible for the SARS outbreak was a member of this coronavirus group...
  76. ncbi request reprint Improved rapid amplification of cDNA ends (RACE) for mapping both the 5' and 3' terminal sequences of paramyxovirus genomes
    Zhuo Li
    Renal Division and Institute of Nephrology, Peking University First Hospital, Beijing, China
    J Virol Methods 130:154-6. 2005
    ..The RACE strategy described in this paper is simple, cost-effective and can be used to map genome ends of any RNA viruses...
  77. pmc Ephrin-B2 ligand is a functional receptor for Hendra virus and Nipah virus
    Matthew I Bonaparte
    Department of Microbiology and Immunology, Uniformed Services University, Bethesda, MD 20814, USA
    Proc Natl Acad Sci U S A 102:10652-7. 2005
    ..Together, these data indicate that EFNB2 serves as a functional receptor for both HeV and NiV. The highly conserved nature of EFNB2 in humans and animals is consistent with the broad tropism exhibited by these emerging zoonotic viruses...
  78. pmc Receptor binding, fusion inhibition, and induction of cross-reactive neutralizing antibodies by a soluble G glycoprotein of Hendra virus
    Katharine N Bossart
    Department of Microbiology and Immunology, F Edward Hebert School of Medicine, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814 4799, USA
    J Virol 79:6690-702. 2005
    ..This HeV sG glycoprotein will be exceedingly useful for structural studies, receptor identification strategies, and vaccine development goals for these important emerging viral agents...
  79. pmc Civets are equally susceptible to experimental infection by two different severe acute respiratory syndrome coronavirus isolates
    Donglai Wu
    National Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, CAAS, Harbin 150001, China
    J Virol 79:2620-5. 2005
    ..Our data show that civets were equally susceptible to SARS-CoV isolates GZ01 and BJ01...
  80. ncbi request reprint Functional and structural characterization of recombinant dermcidin-1L, a human antimicrobial peptide
    Yu Ping Lai
    Laboratory of Molecular Biology, School of Life Sciences, East China Normal University, Shanghai, China
    Biochem Biophys Res Commun 328:243-50. 2005
    ..Our results confirmed previous findings indicating that dermcidin-1L could have promising therapeutic potentials and shed new light on the structure-function relationship of dermcidin-1L...
  81. pmc Antibodies to SARS coronavirus in civets
    Changchun Tu
    Changchun University of Agriculture and Animal Sciences, Changchun, China
    Emerg Infect Dis 10:2244-8. 2004
    ....
  82. pmc Mimotopes of the Vi antigen of Salmonella enterica serovar typhi identified from phage display peptide library
    Swee Seong Tang
    Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia
    Clin Diagn Lab Immunol 10:1078-84. 2003
    ..Data and reagents generated in this study have important implications for the development of peptide-base diagnostic tests and peptide vaccines and may also provide a better understanding of the pathogenesis of typhoid fever...
  83. ncbi request reprint A comparative indirect ELISA for the detection of henipavirus antibodies based on a recombinant nucleocapsid protein expressed in Escherichia coli
    Ji Ming Chen
    Chinese National Diagnostic Center for Exotic Animal Diseases, Chinese National Animal Quarantine Institute, Qingdao 266032, China
    J Virol Methods 136:273-6. 2006
    ..The use of recombinant protein as the ELISA antigen, instead of inactivated virus antigens, will be of significant advantage for countries where there is no facility of Biosafety level 4 to handle this group of zoonotic viruses...
  84. pmc Feline model of acute nipah virus infection and protection with a soluble glycoprotein-based subunit vaccine
    Bruce A Mungall
    Department of Microbiology and Immunology, Uniformed Services University, Bethesda, MD 20814, USA
    J Virol 80:12293-302. 2006
    ..These results indicate that the cat provides a consistent model for acute NiV infection and associated pathogenesis and an effective subunit vaccine strategy appears achievable...
  85. ncbi request reprint Full-length genome sequences of two SARS-like coronaviruses in horseshoe bats and genetic variation analysis
    Wuze Ren
    State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences CAS, Wuhan, Hubei 430071, China
    J Gen Virol 87:3355-9. 2006
    ..Genetic analysis demonstrated that a diverse G2b-CoV population exists in the bat habitat and has evolved from a common ancestor of SARS-CoV...
  86. pmc Duration of antibody responses after severe acute respiratory syndrome
    Li Ping Wu
    Shanxi Provincial Center for Disease Control and Prevention, Taiyuan, People s Republic of China
    Emerg Infect Dis 13:1562-4. 2007
    ..Thus, SARS patients might be susceptible to reinfection >or=3 years after initial exposure...
  87. pmc Difference in receptor usage between severe acute respiratory syndrome (SARS) coronavirus and SARS-like coronavirus of bat origin
    Wuze Ren
    State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei 430071, China
    J Virol 82:1899-907. 2008
    ..The significance of these findings in relation to virus origin, virus recombination, and host switching is discussed...
  88. ncbi request reprint In utero transmission of Nipah virus: role played by pregnancy and vertical transmission in Henipavirus epidemiology
    Dimiter S Dimitrov
    J Infect Dis 196:807-9. 2007
  89. pmc Residues in the stalk domain of the hendra virus g glycoprotein modulate conformational changes associated with receptor binding
    Kimberly A Bishop
    Department of Microbiology and Immunology, Uniformed Services University, Bethesda, MD 20814, USA
    J Virol 82:11398-409. 2008
    ..Together, these data suggest the stalk domain of G plays an important role in the conformational stability and receptor binding-triggered changes leading to productive fusion, such as the dissociation of G and F...
  90. pmc Identification of Hendra virus G glycoprotein residues that are critical for receptor binding
    Kimberly A Bishop
    Department of Microbiology and Immunology, Uniformed Services University, Bethesda, MD 20814, USA
    J Virol 81:5893-901. 2007
    ....
  91. ncbi request reprint Expression of truncated phosphoproteins of Nipah virus and Hendra virus in Escherichia coli for the differentiation of henipavirus infections
    Ji Ming Chen
    China Animal Health and Epidemiology Center, Qingdao, China
    Biotechnol Lett 29:871-5. 2007
    ..The longer pair of truncated recombinant phosphoproteins, covering amino acid residues 4-550, was more antigenic than the shorter one and of potential utility in the serological differentiation of henipavirus infections...
  92. ncbi request reprint Generation of henipavirus nucleocapsid proteins in yeast Saccharomyces cerevisiae
    Mindaugas Juozapaitis
    Institute of Biotechnology, V Graiciuno 8, Vilnius LT 02241, Lithuania
    Virus Res 124:95-102. 2007
    ..The development of an efficient and cost-effective system for generation of henipavirus nucleocapsid proteins might help to improve reagents for diagnosis of viruses...
  93. doi request reprint Exceptionally potent cross-reactive neutralization of Nipah and Hendra viruses by a human monoclonal antibody
    Zhongyu Zhu
    Protein Interactions Group, Center for Cancer Research Nanobiology Program, Center for Cancer Research, National Cancer Institute Frederick, National Institutes of Health, Frederick, MD 21702 1201, USA
    J Infect Dis 197:846-53. 2008
    ..These results suggest that m102.4 has potential as a therapeutic agent for the treatment of diseases caused by henipaviruses. It could be also used for prophylaxis and diagnosis, and as a research reagent...
  94. ncbi request reprint A new approach to random mutagenesis in vitro
    Yu Ping Lai
    Department of Biology, School of Life Sciences, East China Normal University, Shanghai, China
    Biotechnol Bioeng 86:622-7. 2004
    ..1%, AT --> GC transition 34.2% and GC/CG transversion 23.7%, respectively. To our knowledge this is the first application of EMS for in vitro mutagenesis of a defined DNA sequence...
  95. pmc Hendra virus V protein inhibits interferon signaling by preventing STAT1 and STAT2 nuclear accumulation
    Jason J Rodriguez
    Immunobiology Center, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Virol 77:11842-5. 2003
    ..These findings demonstrate a V protein-mediated IFN signal evasion mechanism that is a general property of the known Henipavirus species...
  96. pmc Tioman virus, a paramyxovirus of bat origin, causes mild disease in pigs and has a predilection for lymphoid tissues
    Koon Chu Yaiw
    Department of Pathology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
    J Virol 82:565-8. 2008
    ..Virus was isolated from oral swabs but not from urine. Our findings suggest that the pig could act as an intermediate or amplifying host for TioPV and that oral secretion is a possible means of viral transmission...
  97. pmc A previously unknown reovirus of bat origin is associated with an acute respiratory disease in humans
    Kaw Bing Chua
    National Public Health Laboratory, Selangor 4700, Malaysia
    Proc Natl Acad Sci U S A 104:11424-9. 2007
    ..These data indicate that bat-borne reoviruses can be transmitted to and cause clinical diseases in humans...
  98. pmc A single amino acid substitution in the V protein of Nipah virus alters its ability to block interferon signalling in cells from different species
    Kathrin Hagmaier
    Centre for Biomolecular Sciences, University of St Andrews, The North Haugh, St Andrews KY16 9ST, UK
    J Gen Virol 87:3649-53. 2006
    ....
  99. doi request reprint Construction of a non-infectious SARS coronavirus replicon for application in drug screening and analysis of viral protein function
    Jian Min Wang
    State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, 44 Xiao Hong Shan, Wuhan, Hubei 430071, PR China
    Biochem Biophys Res Commun 374:138-42. 2008
    ....