J N Varghese

Summary

Country: Australia

Publications

  1. ncbi request reprint Three-dimensional structure of a barley beta-D-glucan exohydrolase, a family 3 glycosyl hydrolase
    J N Varghese
    Biomolecular Research Institute, 343 Royal Parade, Parkville, Victoria 3052 Australia
    Structure 7:179-90. 1999
  2. pmc Structural evidence for a second sialic acid binding site in avian influenza virus neuraminidases
    J N Varghese
    Biomolecular Research Institute, 343 Royal Parade, Parkville, 3052 Australia
    Proc Natl Acad Sci U S A 94:11808-12. 1997
  3. ncbi request reprint Drug design against a shifting target: a structural basis for resistance to inhibitors in a variant of influenza virus neuraminidase
    J N Varghese
    Biomolecular Research Institute 343 Royal Parade, Parkville, 3052, Australia
    Structure 6:735-46. 1998
  4. pmc Mutations in a conserved residue in the influenza virus neuraminidase active site decreases sensitivity to Neu5Ac2en-derived inhibitors
    J L McKimm-Breschkin
    Biomolecular Research Institute, Parkville, Australia
    J Virol 72:2456-62. 1998
  5. ncbi request reprint Substrate, inhibitor, or antibody stabilizes the Glu 119 Gly mutant influenza virus neuraminidase
    A Sahasrabudhe
    Biomolecular Research Institute, Parkville, Victoria, Australia
    Virology 247:14-21. 1998
  6. pmc Analysis of inhibitor binding in influenza virus neuraminidase
    B J Smith
    Biomolecular Research Institute, Parkville, Victoria 3052, Australia
    Protein Sci 10:689-96. 2001
  7. pmc Three-dimensional structures of two plant beta-glucan endohydrolases with distinct substrate specificities
    J N Varghese
    Biomolecular Research Institute, Parkville, Victoria, Australia
    Proc Natl Acad Sci U S A 91:2785-9. 1994
  8. ncbi request reprint Mutant barley (1-->3,1-->4)-beta-glucan endohydrolases with enhanced thermostability
    R J Stewart
    Department of Plant Science, University of Adelaide, Waite Campus, Glen Osmond, SA 5064, Biomolecular Research Institute, 343 Royal Parade, Parkville, VIC 3052
    Protein Eng 14:245-53. 2001
  9. pmc Structure of the extracellular domains of the human interleukin-6 receptor alpha -chain
    J N Varghese
    Biomolecular Research Institute and Commonwealth Scientific and Industrial Research Organization Health Sciences and Nutrition, 343 Royal Parade, Parkville 3052, Australia
    Proc Natl Acad Sci U S A 99:15959-64. 2002
  10. pmc Structural evidence for evolution of shark Ig new antigen receptor variable domain antibodies from a cell-surface receptor
    V A Streltsov
    Division of Health Sciences and Nutrition, Commonwealth Scientific and Industrial Research Organization, and Cooperative Research Centre for Diagnostics, 343 Royal Parade, Parkville 3052, Australia
    Proc Natl Acad Sci U S A 101:12444-9. 2004

Collaborators

Detail Information

Publications10

  1. ncbi request reprint Three-dimensional structure of a barley beta-D-glucan exohydrolase, a family 3 glycosyl hydrolase
    J N Varghese
    Biomolecular Research Institute, 343 Royal Parade, Parkville, Victoria 3052 Australia
    Structure 7:179-90. 1999
    ..These key processes of plant development are mediated by several polysaccharide endohydrolases and exohydrolases...
  2. pmc Structural evidence for a second sialic acid binding site in avian influenza virus neuraminidases
    J N Varghese
    Biomolecular Research Institute, 343 Royal Parade, Parkville, 3052 Australia
    Proc Natl Acad Sci U S A 94:11808-12. 1997
    ..The residues that interact with Neu5Ac at this second site are mostly conserved in avian strains, but not in human and swine strains, indicating that it has some as-yet-unknown biological function in birds...
  3. ncbi request reprint Drug design against a shifting target: a structural basis for resistance to inhibitors in a variant of influenza virus neuraminidase
    J N Varghese
    Biomolecular Research Institute 343 Royal Parade, Parkville, 3052, Australia
    Structure 6:735-46. 1998
    ..This study seeks to clarify the structural and functional consequences of replacing the glycerol sidechain of the inhibitor with other chemical constituents...
  4. pmc Mutations in a conserved residue in the influenza virus neuraminidase active site decreases sensitivity to Neu5Ac2en-derived inhibitors
    J L McKimm-Breschkin
    Biomolecular Research Institute, Parkville, Australia
    J Virol 72:2456-62. 1998
    ..Altered binding of the hydrophobic side chain at the 6 position or the triol group could account for the decreased binding of both the NA inhibitors and substrate...
  5. ncbi request reprint Substrate, inhibitor, or antibody stabilizes the Glu 119 Gly mutant influenza virus neuraminidase
    A Sahasrabudhe
    Biomolecular Research Institute, Parkville, Victoria, Australia
    Virology 247:14-21. 1998
    ..Furthermore the presence of high levels of substrate, either cell or virus associated, may be sufficient to stabilize the NA during virus replication...
  6. pmc Analysis of inhibitor binding in influenza virus neuraminidase
    B J Smith
    Biomolecular Research Institute, Parkville, Victoria 3052, Australia
    Protein Sci 10:689-96. 2001
    ....
  7. pmc Three-dimensional structures of two plant beta-glucan endohydrolases with distinct substrate specificities
    J N Varghese
    Biomolecular Research Institute, Parkville, Victoria, Australia
    Proc Natl Acad Sci U S A 91:2785-9. 1994
    ....
  8. ncbi request reprint Mutant barley (1-->3,1-->4)-beta-glucan endohydrolases with enhanced thermostability
    R J Stewart
    Department of Plant Science, University of Adelaide, Waite Campus, Glen Osmond, SA 5064, Biomolecular Research Institute, 343 Royal Parade, Parkville, VIC 3052
    Protein Eng 14:245-53. 2001
    ..Thus, this loop represents a particularly unstable region of the enzyme and could be involved in the initiation of unfolding of the (1-->3,1-->4)-beta-glucanase at elevated temperatures...
  9. pmc Structure of the extracellular domains of the human interleukin-6 receptor alpha -chain
    J N Varghese
    Biomolecular Research Institute and Commonwealth Scientific and Industrial Research Organization Health Sciences and Nutrition, 343 Royal Parade, Parkville 3052, Australia
    Proc Natl Acad Sci U S A 99:15959-64. 2002
    ....
  10. pmc Structural evidence for evolution of shark Ig new antigen receptor variable domain antibodies from a cell-surface receptor
    V A Streltsov
    Division of Health Sciences and Nutrition, Commonwealth Scientific and Industrial Research Organization, and Cooperative Research Centre for Diagnostics, 343 Royal Parade, Parkville 3052, Australia
    Proc Natl Acad Sci U S A 101:12444-9. 2004
    ..Unusually, the 12Y-2 complementarity-determining region 3 also adopts an extended beta-hairpin structure, suggesting a distinct selective advantage in accessing cryptic antigenic epitopes...