Heddy Zola

Summary

Affiliation: University of Adelaide
Country: Australia

Publications

  1. ncbi request reprint CD molecules 2006--human cell differentiation molecules
    Heddy Zola
    Child Health Research Institute and Adelaide University Discipline of Paediatrics, 72 King William Road, North Adelaide, South Australia 5006, Australia
    J Immunol Methods 319:1-5. 2007
  2. ncbi request reprint 1D09C3, an mAb specific for MHC-II
    Heddy Zola
    Women s and Children s Health Research Institute, 72 King William Road, North Adelaide, SA 5006, South Australia
    Curr Opin Mol Ther 10:68-74. 2008
  3. ncbi request reprint Human leukocyte differentiation antigens as therapeutic targets: the CD molecules and CD antibodies
    H Zola
    Child Health Research Institute, 72 King William Road, North Adelaide 5006, Australia
    Expert Opin Biol Ther 1:375-83. 2001
  4. ncbi request reprint The human leucocyte differentiation antigens (HLDA) workshops: the evolving role of antibodies in research, diagnosis and therapy
    Heddy Zola
    Leucocyte Biology Laboratory, Child Health Research Institute, North Adelaide, Australia
    Cell Res 15:691-4. 2005
  5. pmc Medical applications of leukocyte surface molecules--the CD molecules
    Heddy Zola
    Child Health Research Institute, Women s and Children s Hospital, Adelaide, Australia
    Mol Med 12:312-6. 2006
  6. ncbi request reprint The 8th Human Leucocyte Differentiation Antigens Workshop: potential new CD molecules
    H Zola
    Child Health Research Institute, Women s and Children s Hospital, and Co operative Research Centre for Diagnostics, Adelaide, Australia
    J Biol Regul Homeost Agents 16:119-24. 2002
  7. ncbi request reprint Human Leucocyte Differentiation Antigen nomenclature: update on CD nomenclature. Report of IUIS/WHO Subcommittee
    Heddy Zola
    Child Health Research Institute and Department of Paediatrics, Women s and Children s Hospital, Adelaide University, Adelaide 5006, Australia
    J Immunol Methods 275:1-8. 2003
  8. ncbi request reprint CD molecules 2005: human cell differentiation molecules
    Heddy Zola
    Child Health Research Institute, 72 King William Rd, North Adelaide 5006, South Australia, Australia
    Blood 106:3123-6. 2005
  9. doi request reprint Genome-wide identification of human FOXP3 target genes in natural regulatory T cells
    Timothy J Sadlon
    Molecular Immunology Laboratory, Women s and Children s Health Research Institute, Women s and Children s Hospital, North Adelaide, South Australia, Australia
    J Immunol 185:1071-81. 2010
  10. doi request reprint Monoclonal antibodies to human cell surface antigens
    Alice Beare
    Women s and Children s Health Research Institute, Women s and Children s Hospital, Adelaide, Australia
    Curr Protoc Immunol . 2008

Collaborators

Detail Information

Publications55

  1. ncbi request reprint CD molecules 2006--human cell differentiation molecules
    Heddy Zola
    Child Health Research Institute and Adelaide University Discipline of Paediatrics, 72 King William Road, North Adelaide, South Australia 5006, Australia
    J Immunol Methods 319:1-5. 2007
    ..At that meeting the Council, acting as Nomenclature Committee, approved a number of new CD designations and changes to some pre-existing CD designations, which are summarized in this report...
  2. ncbi request reprint 1D09C3, an mAb specific for MHC-II
    Heddy Zola
    Women s and Children s Health Research Institute, 72 King William Road, North Adelaide, SA 5006, South Australia
    Curr Opin Mol Ther 10:68-74. 2008
    ..In December 2006, positive safety data from two phase I clinical trials were reported. Final phase I data were expected in mid-2007; however, no additional data have been released at the time of publication...
  3. ncbi request reprint Human leukocyte differentiation antigens as therapeutic targets: the CD molecules and CD antibodies
    H Zola
    Child Health Research Institute, 72 King William Road, North Adelaide 5006, Australia
    Expert Opin Biol Ther 1:375-83. 2001
    ..The author is responsible for organising the next (8th) HLDA Workshop and invites readers to suggest ways in which the therapeutic relevance of the Workshop may be enhanced...
  4. ncbi request reprint The human leucocyte differentiation antigens (HLDA) workshops: the evolving role of antibodies in research, diagnosis and therapy
    Heddy Zola
    Leucocyte Biology Laboratory, Child Health Research Institute, North Adelaide, Australia
    Cell Res 15:691-4. 2005
    ..We consider what remains to be achieved (including an estimate of the number of leucocyte surface molecules still to be discovered), and how the field can best move forward...
  5. pmc Medical applications of leukocyte surface molecules--the CD molecules
    Heddy Zola
    Child Health Research Institute, Women s and Children s Hospital, Adelaide, Australia
    Mol Med 12:312-6. 2006
    ..This short review provides a background to the CD molecules and antibodies against them, and summarizes research, diagnostic, and therapeutic applications of antibodies against these molecules...
  6. ncbi request reprint The 8th Human Leucocyte Differentiation Antigens Workshop: potential new CD molecules
    H Zola
    Child Health Research Institute, Women s and Children s Hospital, and Co operative Research Centre for Diagnostics, Adelaide, Australia
    J Biol Regul Homeost Agents 16:119-24. 2002
  7. ncbi request reprint Human Leucocyte Differentiation Antigen nomenclature: update on CD nomenclature. Report of IUIS/WHO Subcommittee
    Heddy Zola
    Child Health Research Institute and Department of Paediatrics, Women s and Children s Hospital, Adelaide University, Adelaide 5006, Australia
    J Immunol Methods 275:1-8. 2003
    ..The major features of the cellular expression patterns are summarised, and a LocusLink accession number provided to enable the reader to access more detailed information through http://www.ncbi.nlm.nih.gov/LocusLink...
  8. ncbi request reprint CD molecules 2005: human cell differentiation molecules
    Heddy Zola
    Child Health Research Institute, 72 King William Rd, North Adelaide 5006, South Australia, Australia
    Blood 106:3123-6. 2005
    ....
  9. doi request reprint Genome-wide identification of human FOXP3 target genes in natural regulatory T cells
    Timothy J Sadlon
    Molecular Immunology Laboratory, Women s and Children s Health Research Institute, Women s and Children s Hospital, North Adelaide, South Australia, Australia
    J Immunol 185:1071-81. 2010
    ....
  10. doi request reprint Monoclonal antibodies to human cell surface antigens
    Alice Beare
    Women s and Children s Health Research Institute, Women s and Children s Hospital, Adelaide, Australia
    Curr Protoc Immunol . 2008
    ....
  11. ncbi request reprint Detection of low-abundance membrane markers by immunofluorescence--a comparison of alternative high-sensitivity methods and reagents
    Christos Mavrangelos
    Child Health Research Institute, Women s and Children s Hospital, North Adelaide SA, Australia
    J Immunol Methods 289:169-78. 2004
    ..Furthermore, the new fluorophores allow improved simultaneous detection of two low-abundance markers...
  12. ncbi request reprint Expression of toll-like receptors on B lymphocytes
    Pallave Dasari
    Child Health Research Institute, 72 King William Road, North Adelaide, SA 5006, Australia
    Cell Immunol 236:140-5. 2005
    ..The higher expression of TLR1 and TLR9 on CD5+ B cells compared to CD5- B cells may reflect the role of B1 cells in more primitive, less specific antibody responses...
  13. doi request reprint Comparison of blood and synovial fluid th17 and novel peptidase inhibitor 16 Treg cell subsets in juvenile idiopathic arthritis
    Randall H Grose
    Women s and Children s Health Research Institute WCHRI, North Adelaide, and the Discipline of Paediatrics, University of Adelaide, Adelaide, Australia
    J Rheumatol 39:2021-31. 2012
    ....
  14. doi request reprint Elevated serum cytokine levels using cytometric bead arrays predict culture-positive infections in childhood oncology patients with febrile neutropenia
    Shiraz Badurdeen
    Child Health Research Institute and CRC for Diagnostics, SA Pathology at Women s and Children s Hospital, North Adelaide, South Australia
    J Pediatr Hematol Oncol 34:e36-8. 2012
    ..Furthermore, low risk of bacteraemia may be predicted by a combination of below threshold cytokines and negative clinical examination...
  15. doi request reprint High-sensitivity immunofluorescence/flow cytometry: detection of cytokine receptors and other low-abundance membrane molecules
    Heddy Zola
    Child Health Research Institute, North Adelaide, Australia
    Curr Protoc Cytom . 2004
    ..This unit discusses the underlying principles of high-sensitivity immunofluorescence and provides an excellent series of protocols for the practical detection of as few as 100 target antigen molecules per cell...
  16. doi request reprint Development of CD4+CD25+FoxP3+ regulatory T cells from cord blood hematopoietic progenitor cells
    Jonathon F Hutton
    Molecular Immunology Laboratory, Discipline of Paediatrics, University of Adelaide, North Adelaide, South Australia 5006
    J Leukoc Biol 85:445-51. 2009
    ..This manipulable culture system, therefore, generates functional Tregs and provides a system to elucidate the mechanism of Treg development...
  17. ncbi request reprint The HLDA8 blind panel: findings and conclusions
    Bernadette Swart
    Child Health Research Institute, Women s and Children s Hospital and Department of Paediatrics, University of Adelaide, 72 King William Rd, North Adelaide, 5006, Australia
    J Immunol Methods 305:75-83. 2005
    ..Several antibody pairs among those in the blind panel were found to have very similar staining patterns and were therefore compared by immunohistochemical and/or Western blot analyses for identity...
  18. doi request reprint PI16 is expressed by a subset of human memory Treg with enhanced migration to CCL17 and CCL20
    Ian C Nicholson
    Women s and Children s Health Research Institute, 72 King William Road, North Adelaide, South Australia, 5006, Australia
    Cell Immunol 275:12-8. 2012
    ..We conclude that PI16 identifies a novel distinct subset of functional memory Treg which can migrate to sites of inflammation and regulate the pro-inflammatory response at those sites...
  19. doi request reprint Expression of Toll-like receptors by neonatal leukocytes
    Pallave Dasari
    Women s and Children s Health Research Institute, Women s and Children s Hospital, Adelaide, SA, Australia
    Pediatr Allergy Immunol 22:221-8. 2011
    ..TLR2, TLR3, TLR4, TLR8 and TLR9 expression by T lymphocytes was detected in adults and neonates. Monocytes and T lymphocytes from neonates are capable, like adults, of recognizing the presence of pathogens through TLR...
  20. ncbi request reprint Cross-reactivity of anti-human chemokine receptor and anti-TNF family antibodies with common marmoset (Callithrix jacchus) leukocytes
    Svjetlana Kireta
    Transplantation Immunology Laboratory and Department of Medicine, University of Adelaide, The Queen Elizabeth Hospital Campus, 28 Woodville Rd, Adelaide, SA 5011, Australia
    Cell Immunol 236:115-22. 2005
    ....
  21. pmc Maternal milk regulation of cell infiltration and interleukin 18 in the intestine of suckling rat pups
    I A Penttila
    Child Health Research Institute, North Adelaide, SA 5006, Australia
    Gut 52:1579-86. 2003
    ..Interleukin 18 (IL-18) is a cytokine that mediates early immune events, and drives T cell development. We assessed the role of TGF-beta in mediating mucosal immune development and specifically the effect on endogenous IL-18...
  22. ncbi request reprint Toll-like receptors
    P Dasari
    Child Health Research Institute, Women s and Children s Hospital, Adelaide, Australia
    J Biol Regul Homeost Agents 22:17-26. 2008
    ..Some of ten toll-like receptors identified in humans are able to recognise several pathogen-associated molecular patterns...
  23. ncbi request reprint The 8th Human Leucocyte Differentiation Antigens Workshop: conference, Adelaide 2004
    H Zola
    Child Health Research Institute, Women s and Children s Hospital, Adelaide, Australia
    J Biol Regul Homeost Agents 19:72. 2005
  24. ncbi request reprint In silico evaluation of two mass spectrometry-based approaches for the identification of novel human leukocyte cell-surface proteins
    I C Nicholson
    Co operative Research Centre for Diagnostics, Women s and Children s Hospital, Adelaide, South Australia, Australia
    J Leukoc Biol 77:190-8. 2005
    ..The implication of this for the use of these techniques in the discovery of new leukocyte cell-surface proteins is discussed...
  25. ncbi request reprint The development of antibody responses in the infant
    H Zola
    Child Health Research Institute, Adelaide, South Australia
    Immunol Cell Biol 75:587-90. 1997
    ..Thus, the mechanisms required to make high-affinity antibody develop gradually during the first year of life. Possible evolutionary reasons for this are discussed...
  26. ncbi request reprint Interleukin 2 receptor regulation and IL-2 function in the human infant
    H Zola
    Child Health Research Institute, Adelaide, Australia
    Hum Immunol 59:615-24. 1998
    ....
  27. ncbi request reprint Markers of cell lineage, differentiation and activation
    H Zola
    Child Health Research Institute, Women s and Children s Hospital, North Adelaide, Australia
    J Biol Regul Homeost Agents 14:218-9. 2000
    ..Lineage markers are the main focus in this commentary; the question of activation markers and markers of differentiation state will be considered in a separate paper...
  28. ncbi request reprint Identification of soluble transforming growth factor-beta receptor III (sTbetaIII) in rat milk
    M Zhang
    Cooperative Research Centre for Tissue Growth and Repair, Child Health Research Institute, North Adelaide, South Australia, Australia
    Immunol Cell Biol 79:291-7. 2001
    ..These findings suggest that milk sTbetaRIII is functional, and may modulate milk-derived TGF-beta function in the developing intestine...
  29. ncbi request reprint Immune modulation in suckling rat pups by a growth factor extract derived from milk whey
    I A Penttila
    CRC for Tissue Growth and Repair, Child Health Research Institute, North Adelaide, South Australia
    J Dairy Res 68:587-99. 2001
    ..Immune modulation by extracts derived from milk whey could be of potential benefit for formula-fed and pre-term infants in reducing susceptibility to inappropriate activation to food antigens...
  30. doi request reprint Cytoskeletal protein Flightless (Flii) is elevated in chronic and acute human wounds and wound fluid: neutralizing its activity in chronic but not acute wound fluid improves cellular proliferation
    Nadira Ruzehaji
    Women s and Children s Health Research Institute, 72 King William Road, North Adelaide, SA, Australia
    Eur J Dermatol 22:740-50. 2012
    ..Application of FnAbs to chronic wounds may therefore be a novel approach used to improve the local environment of non-healing wounds and potentially improve healing outcomes...
  31. ncbi request reprint Characterisation of the protein composition of peripheral blood mononuclear cell microsomes by SDS-PAGE and mass spectrometry
    Ian C Nicholson
    Child Health Research Institute, Adelaide, Australia Cooperative Research Centre for Diagnostics, Australia
    J Immunol Methods 305:84-93. 2005
    ..These results show that previously unidentified lymphocyte plasma membrane proteins can be identified using this approach...
  32. ncbi request reprint Localization of transforming growth factor-beta receptor types I, II, and III in the postnatal rat small intestine
    M F Zhang
    Cooperative Research Centre, for Tissue Growth and Repair, Child Health Research Institute, North Adelaide, South Australia
    Pediatr Res 46:657-65. 1999
    ..The pattern of TGF-beta receptor expression changes with age in a manner that may reflect the change in ligand from TGF-beta2 (milk-derived) to TGF-beta1 (endogenously produced)...
  33. ncbi request reprint Conservation of leukocyte cell surface proteins: implications for the generation of monoclonal antibodies against newly identified leukocyte cell surface proteins
    H Zola
    Child Health Research Institute, Women s and Children s Hospital, 72 King William Road, North Adelaide 5006, Australia
    Tissue Antigens 68:13-8. 2006
    ..The results indicate that chicken antibodies have the potential to be used as an alternative to mouse reagents where human-mouse sequence conservation is high...
  34. doi request reprint Immune activation in irritable bowel syndrome: can neuroimmune interactions explain symptoms?
    Patrick A Hughes
    University of Adelaide, Adelaide, South Australia, Australia
    Am J Gastroenterol 108:1066-74. 2013
    ..Identifying what the key changes in the GI immune system are in IBS and how these changes modulate viscerosensory nervous function is essential for the development of novel therapies for the underlying disorder. ..
  35. doi request reprint Reticulin fibres anchor leukaemic blasts in the marrow of patients with acute lymphoblastic leukaemia
    Shriram V Nath
    Department of Haematology Oncology, SA Pathology at WCH, Adelaide, Australia
    Med Hypotheses 77:333-5. 2011
    ..Mobilizing the cells by breaking the 'anchoring ropes' could lead to greater exposure to apoptotic signals...
  36. ncbi request reprint Characterization of colonic and mesenteric lymph node dendritic cell subpopulations in a murine adoptive transfer model of inflammatory bowel disease
    John Karlis
    Child Health Research Institute, Women s and Children s Hospital, North Adelaide, Australia
    Inflamm Bowel Dis 10:834-47. 2004
    ..Mature intestinal dendritic cells may form a nucleation site for a local T cell response and play an important role in the pathogenesis of IBD...
  37. ncbi request reprint Isolation, propagation and characterization of cord blood derived CD4+ CD25+ regulatory T cells
    Suzanne Bresatz
    Discipline of Paediatrics, Adelaide, Australia
    J Immunol Methods 327:53-62. 2007
    ..Protocols are presented for propagation of these cells in culture (yielding >80% FOXP3 positive cells) and for their phenotypic and functional characterization...
  38. ncbi request reprint Detection of cytokine receptors by flow cytometry
    H Zola
    Child Health Research Institute, Adelaide, Australia
    Curr Protoc Immunol . 2001
    ..Instructions are also provided for titrating MAbs and cytokines, as well as how to evaluate detection reagents such as anti-Ig conjugates and fluorophores...
  39. ncbi request reprint The Fc receptor for IgG (Fc gamma RII; CD32) on human neonatal B lymphocytes
    C F Jessup
    Child Health Research Institute, Womens and Childrens Hospital, 5006, North Adelaide SA, Australia
    Hum Immunol 62:679-85. 2001
    ..This quantitative difference in FcgammaRIIb expression may explain the reduced susceptibility of cord B cells to antibody-mediated inhibition observed in these experiments...
  40. ncbi request reprint Isolation of antigen-specific B cells
    Aruna P Kodituwakku
    Department of Paediatrics, University of Adelaide, Women s and Children s Hospital, North Adelaide, South Australia, Australia
    Immunol Cell Biol 81:163-70. 2003
    ..Particular emphasis has been placed on yield and purity; the two most important parameters of any purification method. The most promising isolation methods have used immunomagnetic sorting and multiparametric flow cytometric analysis...
  41. ncbi request reprint An economical 20 litre bench-top fermenter
    Michael A Thiel
    Department of Ophthalmology, Flinders University of South Australia, Adelaide, Australia
    Protein Expr Purif 26:14-8. 2002
    ..5mg/litre/day achieved in shake flasks. The fermenter may be particularly suited for research purposes...
  42. ncbi request reprint FcgammaRIIb expression on human germinal center B lymphocytes
    Peter J Macardle
    Department of Immunology, Allergy and Arthritis, Flinders Medical Centre and Flinders University of South Australia, Bedford Park, South Australia, Australia
    Eur J Immunol 32:3736-44. 2002
    ..Our results cast some doubt on the value of anti-IgG as a model for antigen-antibody complexes in studying human B cell regulation...
  43. ncbi request reprint Tolerization as a tool for generating novel monoclonal antibodies
    Felicity L Holbrook
    Department of Paediatrics and CRC for Diagnostics, Child Health Research Institute, Adelaide University, Adelaide, South Australia, Australia
    Immunol Cell Biol 80:319-22. 2002
    ..This review details a number of strategies using either complex protein mixtures or purified proteins as tolerogens and subsequent immunization with a closely related immunogen...
  44. ncbi request reprint Cytokine receptor expression by solid tumours
    J Ridings
    Child Health Research Institute, Women s and Children s Hospital, Adelaide, South Australia
    Ther Immunol 2:67-76. 1995
    ..The broad expression of cytokine receptors suggests that the receptor profile of individual tumours should be determined before the application of therapy that involves the administration of cytokines...
  45. ncbi request reprint Histamine receptors on T lymphocytes
    N L Perry
    Child Health Research Institute, Women s and Children s Hospital, North Adelaide, Australia
    J Biol Regul Homeost Agents 19:78-83. 2005
  46. ncbi request reprint Direct demonstration of membrane IL-1 alpha on the surface of circulating B lymphocytes and monocytes
    H Zola
    Department of Clinical Immunology, Flinders Medical Centre, Adelaide, South Australia
    J Immunol 150:1755-62. 1993
    ..Activation of tonsil B cells with anti-IgM, IL-4, IL-2, and mixtures of these reagents led to small increases in IL-1 alpha expression, as did activation of unfractionated tonsil cells with PHA...
  47. pmc Rapid simultaneous measurement of multiple cytokines using 100 microl sample volumes--association with neonatal sepsis
    G Hodge
    Department of Haematology, Women s and Children s Hospital, North Adelaide, South Australia
    Clin Exp Immunol 137:402-7. 2004
    ..In conclusion, neonatal sepsis is associated with the elevation of multiple plasma cytokines. The use of CBA kits is a rapid, easy, low sample volume and sensitive method to measure multiple plasma cytokines...
  48. ncbi request reprint Antibody against CD20 in patients with B cell malignancy
    P J Adamson
    Child Health Research Institute, Women's and Children's Hospital, University of Adelaide, 72 King William Road, Adelaide 5006, Australia
    Leuk Res 25:1047-50. 2001
    ..To identify a good donor for library construction, it would be advisable to screen donors for antibody against the antigens of interest...
  49. ncbi request reprint A comparison of Verotoxin B-subunit (Stx1B) and CD77 antibody to define germinal centre populations
    S Bailey
    Department of Immunology, Allergy and Arthritis, Flinders Medical Centre and Flinders University, Adelaide, SA, Australia
    Cell Immunol 236:167-70. 2005
    ..The strong staining patterns of Stx1B suggest that it may be useful in defining germinal center B cell populations...
  50. ncbi request reprint CD antigens 2002
    David Mason
    Blood 99:3877-80. 2002
  51. ncbi request reprint Human leucocyte differentiation antigens
    Heddy Zola
    Trends Immunol 24:353-4. 2003
  52. ncbi request reprint CD Antigens 2001
    David Mason
    Haematology Department, John Radcliffe Hospital, Oxford, OX3 9DU, United Kingdom
    Mod Pathol 15:71-6. 2002
  53. ncbi request reprint Reference: CD Antigens 2002
    David Mason
    Nuffield Department of Clinical Laboratory Sciences, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK
    J Immunol 168:2083-6. 2002
  54. ncbi request reprint Development of a cluster of differentiation antibody-based protein microarray
    Michael Abdo
    CSIRO Division of Health Sciences and Nutrition, 343 Royal Parade, Parkville, Victoria 3052, Australia
    J Immunol Methods 305:3-9. 2005
    ....
  55. ncbi request reprint Generation of murine monoclonal antibodies to Haemophilus influenzae type b capsular polysaccharide by in vivo immunization
    Aruna P Kodituwakku
    Department of Paediatrics, University of Adelaide
    Hybrid Hybridomics 23:160-7. 2004
    ..The anti-PRP antibodies from one hybridoma clone (B10) are further characterized and potential applications are discussed...