John J Zaunders

Summary

Affiliation: University of New South Wales
Country: Australia

Publications

  1. pmc Pathogenicity and immunogenicity of attenuated, nef-deleted HIV-1 strains in vivo
    Paul R Gorry
    Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Victoria, Australia
    Retrovirology 4:66. 2007
  2. pmc Antibody microarray analysis of cell surface antigens on CD4+ and CD8+ T cells from HIV+ individuals correlates with disease stages
    Jing Qin Wu
    Retroviral Genetics Division, Center for Virus Research, Westmead Millennium Institute, Darcy Road, Westmead, NSW 2145, Sydney, Australia
    Retrovirology 4:83. 2007
  3. pmc CD127+CCR5+CD38+++ CD4+ Th1 effector cells are an early component of the primary immune response to vaccinia virus and precede development of interleukin-2+ memory CD4+ T cells
    John J Zaunders
    Centre for Immunology, St Vincent s Hospital, Victoria Street, Darlinghurst, NSW 2010, Australia
    J Virol 80:10151-61. 2006
  4. doi request reprint High levels of human antigen-specific CD4+ T cells in peripheral blood revealed by stimulated coexpression of CD25 and CD134 (OX40)
    John J Zaunders
    Centre for Immunology, St Vincent s Hospital, Sydney, New South Wales, Australia
    J Immunol 183:2827-36. 2009
  5. ncbi request reprint Identification of circulating antigen-specific CD4+ T lymphocytes with a CCR5+, cytotoxic phenotype in an HIV-1 long-term nonprogressor and in CMV infection
    John J Zaunders
    Centre for Immunology, St Vincent s Hospital, and University of New South Wales, Sydney, Australia
    Blood 103:2238-47. 2004
  6. ncbi request reprint Increased turnover of CCR5+ and redistribution of CCR5- CD4 T lymphocytes during primary human immunodeficiency virus type 1 infection
    J J Zaunders
    Centre for Immunology, St Vincent s Hospital, Darlinghurst, NSW 2010, Australia
    J Infect Dis 183:736-43. 2001
  7. ncbi request reprint Effect of long-term infection with nef-defective attenuated HIV type 1 on CD4+ and CD8+ T lymphocytes: increased CD45RO+CD4+ T lymphocytes and limited activation of CD8+ T lymphocytes
    J J Zaunders
    Centre for Immunology, St Vincent s Hospital, Darlinghurst, NSW, Australia
    AIDS Res Hum Retroviruses 15:1519-27. 1999
  8. ncbi request reprint Early proliferation of CCR5(+) CD38(+++) antigen-specific CD4(+) Th1 effector cells during primary HIV-1 infection
    John J Zaunders
    Centre for Immunology, St Vincent s Hospital, Victoria St, Darlinghurst, NSW 2010 Australia
    Blood 106:1660-7. 2005
  9. ncbi request reprint Potent antiretroviral therapy of primary human immunodeficiency virus type 1 (HIV-1) infection: partial normalization of T lymphocyte subsets and limited reduction of HIV-1 DNA despite clearance of plasma viremia
    J J Zaunders
    Centre for Immunology, St Vincent s Hospital, UNSW, Darlinghurst, Australia 2010 Australia
    J Infect Dis 180:320-9. 1999
  10. pmc Infection of CD127+ (interleukin-7 receptor+) CD4+ cells and overexpression of CTLA-4 are linked to loss of antigen-specific CD4 T cells during primary human immunodeficiency virus type 1 infection
    John J Zaunders
    Centre for Immunology, St Vincent s Hospital, Victoria Street, Darlinghurst, NSW 2010, Australia
    J Virol 80:10162-72. 2006

Detail Information

Publications37

  1. pmc Pathogenicity and immunogenicity of attenuated, nef-deleted HIV-1 strains in vivo
    Paul R Gorry
    Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Victoria, Australia
    Retrovirology 4:66. 2007
    ....
  2. pmc Antibody microarray analysis of cell surface antigens on CD4+ and CD8+ T cells from HIV+ individuals correlates with disease stages
    Jing Qin Wu
    Retroviral Genetics Division, Center for Virus Research, Westmead Millennium Institute, Darcy Road, Westmead, NSW 2145, Sydney, Australia
    Retrovirology 4:83. 2007
    ....
  3. pmc CD127+CCR5+CD38+++ CD4+ Th1 effector cells are an early component of the primary immune response to vaccinia virus and precede development of interleukin-2+ memory CD4+ T cells
    John J Zaunders
    Centre for Immunology, St Vincent s Hospital, Victoria Street, Darlinghurst, NSW 2010, Australia
    J Virol 80:10151-61. 2006
    ..The current study provides important information on the differentiation of IL-2+ vaccinia virus-specific memory cells, allowing further study of antiviral effector CD4+ T cells in healthy adults and their dysfunction in HIV-1 infection...
  4. doi request reprint High levels of human antigen-specific CD4+ T cells in peripheral blood revealed by stimulated coexpression of CD25 and CD134 (OX40)
    John J Zaunders
    Centre for Immunology, St Vincent s Hospital, Sydney, New South Wales, Australia
    J Immunol 183:2827-36. 2009
    ..In addition to revealing the true extent of Ag-specific human CD4(+) memory T lymphocytes, its greatest use will be as a simple in vitro monitor of CD4(+) T cell responses to Ags such as tuberculosis infection or vaccines...
  5. ncbi request reprint Identification of circulating antigen-specific CD4+ T lymphocytes with a CCR5+, cytotoxic phenotype in an HIV-1 long-term nonprogressor and in CMV infection
    John J Zaunders
    Centre for Immunology, St Vincent s Hospital, and University of New South Wales, Sydney, Australia
    Blood 103:2238-47. 2004
    ..Moreover, expression of CCR5 may render them particularly susceptible to cytopathic effects during progressive HIV-1 infection...
  6. ncbi request reprint Increased turnover of CCR5+ and redistribution of CCR5- CD4 T lymphocytes during primary human immunodeficiency virus type 1 infection
    J J Zaunders
    Centre for Immunology, St Vincent s Hospital, Darlinghurst, NSW 2010, Australia
    J Infect Dis 183:736-43. 2001
    ..In contrast, in acute EBV infection, proliferating CCR5+ CD4 T cells accumulated to very high levels, suggesting they have an important role in the early antiviral response, which may be impaired in HIV-1 infection...
  7. ncbi request reprint Effect of long-term infection with nef-defective attenuated HIV type 1 on CD4+ and CD8+ T lymphocytes: increased CD45RO+CD4+ T lymphocytes and limited activation of CD8+ T lymphocytes
    J J Zaunders
    Centre for Immunology, St Vincent s Hospital, Darlinghurst, NSW, Australia
    AIDS Res Hum Retroviruses 15:1519-27. 1999
    ....
  8. ncbi request reprint Early proliferation of CCR5(+) CD38(+++) antigen-specific CD4(+) Th1 effector cells during primary HIV-1 infection
    John J Zaunders
    Centre for Immunology, St Vincent s Hospital, Victoria St, Darlinghurst, NSW 2010 Australia
    Blood 106:1660-7. 2005
    ..These results suggest that the antiviral response to HIV-1 infection includes highly activated CCR5(+)CD4(+) cytotoxic effector cells, which are susceptible to both apoptosis and cytopathic infection with HIV-1, and rapidly decline...
  9. ncbi request reprint Potent antiretroviral therapy of primary human immunodeficiency virus type 1 (HIV-1) infection: partial normalization of T lymphocyte subsets and limited reduction of HIV-1 DNA despite clearance of plasma viremia
    J J Zaunders
    Centre for Immunology, St Vincent s Hospital, UNSW, Darlinghurst, Australia 2010 Australia
    J Infect Dis 180:320-9. 1999
    ..The persistence of HIV-1 DNA together with increased CD8 T lymphocyte turnover and activation indicate continued expression of viral antigens...
  10. pmc Infection of CD127+ (interleukin-7 receptor+) CD4+ cells and overexpression of CTLA-4 are linked to loss of antigen-specific CD4 T cells during primary human immunodeficiency virus type 1 infection
    John J Zaunders
    Centre for Immunology, St Vincent s Hospital, Victoria Street, Darlinghurst, NSW 2010, Australia
    J Virol 80:10162-72. 2006
    ..Taken together, the loss of HIV-specific CD4+ T cells is associated with a combination of an infection of CCR5+ CD127+ memory CD4+ T cells, possibly in GALT, and a high expression of the inhibitory receptor CTLA-4...
  11. pmc Progressive activation of CD127+132- recent thymic emigrants into terminally differentiated CD127-132+ T-cells in HIV-1 infection
    Sarah C Sasson
    The Kirby Institute, The University of New South Wales, Sydney, Australia
    PLoS ONE 7:e31148. 2012
    ..We investigated the correlates of loss of CD127 from the T-cell surface to understand mechanisms underlying this homeostatic dysregulation...
  12. pmc Mechanisms of HIV non-progression; robust and sustained CD4+ T-cell proliferative responses to p24 antigen correlate with control of viraemia and lack of disease progression after long-term transfusion-acquired HIV-1 infection
    Wayne B Dyer
    Australian Red Cross Blood Service, 153 Clarence Street, Sydney, NSW 2000, Australia
    Retrovirology 5:112. 2008
    ..We examined the mechanisms that differentiated delayed progressors from LTNP in this cohort...
  13. doi request reprint A culture amplified multi-parametric intracellular cytokine assay (CAMP-ICC) for enhanced detection of antigen specific T-cell responses
    C Mee Ling Munier
    HIV Immunovirology Laboratory, St Vincent s Centre for Applied Medical Research, Sydney, NSW, Australia
    J Immunol Methods 345:1-16. 2009
    ..The CAMP-ICC provides much more information than conventional functional T-cell assays allowing simultaneous determination of proliferative capacity and cytokine production by both CD4 and CD8+ T cells...
  14. ncbi request reprint The role of hydroxyurea in enhancing the virologic control achieved through structured treatment interruption in primary HIV infection: final results from a randomized clinical trial (Pulse)
    Mark T Bloch
    Holdsworth House Medical Practice, Sydney, New South Wales, Australia
    J Acquir Immune Defic Syndr 42:192-202. 2006
    ..The addition of hydroxyurea (HU) may reduce viral production from activated CD4 cells...
  15. ncbi request reprint Polyclonal proliferation and apoptosis of CCR5+ T lymphocytes during primary human immunodeficiency virus type 1 infection: regulation by interleukin (IL)-2, IL-15, and Bcl-2
    John J Zaunders
    Centre for Immunology, St Vincent s Hospital, Darlinghurst, New South Wales, Australia
    J Infect Dis 187:1735-47. 2003
    ..Understanding cytokine effects on CCR5(+) T cells will be important in understanding chronic HIV-1 replication and pathogenesis...
  16. ncbi request reprint Increased plasma interleukin-7 level correlates with decreased CD127 and Increased CD132 extracellular expression on T cell subsets in patients with HIV-1 infection
    Sarah C Sasson
    National Centre in HIV Epidemiology and Clinical Research, Sydney, Australia
    J Infect Dis 193:505-14. 2006
    ....
  17. doi request reprint IL-7 receptor is expressed on adult pre-B-cell acute lymphoblastic leukemia and other B-cell derived neoplasms and correlates with expression of proliferation and survival markers
    Sarah C Sasson
    National Centre in HIV Epidemiology and Clinical Research, University of New South Wales, Sydney, Australia
    Cytokine 50:58-68. 2010
    ..Patients with B-cell derived neoplasms had elevated circulating IL-10 and decreased BAFF. These findings support a role for the IL-7/IL-7R system in B-cell oncogenesis...
  18. ncbi request reprint The IL-7/IL-7 receptor axis: understanding its central role in T-cell homeostasis and the challenges facing its utilization as a novel therapy
    Sarah C Sasson
    National Centre in HIV Epidemiology and Clinical Research, University of New South Wales, Sydney, Australia
    Curr Drug Targets 7:1571-82. 2006
    ..Ultimately this understanding may lead to therapeutics that manipulate and optimise signalling through the IL-7/IL-7R system...
  19. doi request reprint Integrated HIV DNA accumulates prior to treatment while episomal HIV DNA records ongoing transmission afterwards
    John M Murray
    School of Mathematics and Statistics, University of New South Wales, Sydney, New South Wales, Australia
    AIDS 26:543-50. 2012
    ..We investigated the dynamics of HIV RNA and HIV DNA levels after the commencement of raltegravir-based antiretroviral therapy (ART) in primary (PHI) and chronically HIV-infected (CHI) individuals (the PINT study)...
  20. doi request reprint Proliferation of weakly suppressive regulatory CD4+ T cells is associated with over-active CD4+ T-cell responses in HIV-positive patients with mycobacterial immune restoration disease
    Nabila Seddiki
    Centre for Immunology, St Vincent s Hospital, Darlinghurst, NSW, Australia
    Eur J Immunol 39:391-403. 2009
    ..These data suggest that despite substantial Treg expansion in IRD, their ability to induce suppression, and thereby downregulate aberrant immune responses, is compromised...
  21. doi request reprint A novel assay detecting recall response to Mycobacterium tuberculosis: Comparison with existing assays
    Denise C Hsu
    The Kirby Institute for Infection and Immunity in Society, University of New South Wales, Sydney, NSW, Australia
    Tuberculosis (Edinb) 92:321-7. 2012
    ..Further study into the performance of this assay is thus warranted...
  22. ncbi request reprint Greater reversal of CD4+ cell abnormalities and viral load reduction after initiation of antiretroviral therapy with zidovudine, lamivudine, and nelfinavir before complete HIV type 1 seroconversion
    Don E Smith
    National Centre in HIV Epidemiology and Clinical Research, University of New South Wales, Sydney, NSW 2010, Australia
    AIDS Res Hum Retroviruses 19:189-99. 2003
    ..Despite poorer prognostic markers at baseline ES subjects achieved responses similar to those of LS subjects after 1 year of treatment...
  23. ncbi request reprint Naive T cells are maintained by thymic output in early ages but by proliferation without phenotypic change after age twenty
    John M Murray
    School of Mathematics, University of NSW, Sydney, Australia
    Immunol Cell Biol 81:487-95. 2003
    ..7 year half-life of the productive thymus so that by age 55 only 5% of naive production arises from thymic export...
  24. ncbi request reprint An examination of signs of disease progression in survivors of the Sydney Blood Bank Cohort (SBBC)
    M R Birch
    HIV Epidemiology Research Unit HERU, Australian Red Cross Blood Service NSW ARCBS NSW, Level 3 131 Clarence Street, Sydney, NSW 2000, Australia
    J Clin Virol 22:263-70. 2001
    ..In contrast, in the SA cohort, comparison study group for the SBBC, five of 24 remain therapy naïve after 15 years infection with HIV-1 and all have detectable VL...
  25. ncbi request reprint Cell turnover and cell tropism in HIV-1 infection
    Miles P Davenport
    Dept of Pathology, Faculty of Medicine, University of New South Wales, NSW 2052, Kensington, Australia
    Trends Microbiol 10:275-8. 2002
    ..As the division rate of naive T cells increases with CD4+ depletion, X4 viruses come to dominate in late disease...
  26. ncbi request reprint Human mesenchymal stem cells constitutively express chemokines and chemokine receptors that can be upregulated by cytokines, IFN-beta, and Copaxone
    Juliana Croitoru-Lamoury
    Centre for Immunology, St Vincent s Hospital, Department of Neurology, Sydney NSW, Australia
    J Interferon Cytokine Res 27:53-64. 2007
    ..Administration of cytokines, including IFN-beta and Copaxone, may be important in stem cell transplantation therapies and perhaps important in the efficacy of existing MS therapies...
  27. ncbi request reprint Phenotypic analysis of CD8+ T lymphocytes in a cohort of HIV type 1-infected patients treated with saquinavir, ritonavir, and two nucleoside analogs for 1 year, and association with plasma HIV type 1 RNA
    G R Kaufmann
    Centre for Immunology, St Vincent s Hospital, Darlinghurst, NSW, Australia
    AIDS Res Hum Retroviruses 15:963-72. 1999
    ..A complete normalization of immunologic changes of CD8+ T lymphocytes would therefore require a more potent drug regimen or a longer duration of therapy...
  28. ncbi request reprint CD8+ anti-human immunodeficiency virus suppressor activity (CASA) in response to antiretroviral therapy: loss of CASA is associated with loss of viremia
    J Wilkinson
    Centre for Immunology, St Vincent s Hospital, Sydney, NSW 2010, Australia
    J Infect Dis 180:68-75. 1999
    ..However, changes in CASA did not correlate with changes in any T lymphocyte subset. CASA increases with improving immune function but appears more dependent on ongoing HIV replication...
  29. ncbi request reprint Long-term immunological response in HIV-1-infected subjects receiving potent antiretroviral therapy
    G R Kaufmann
    National Centre in HIV Epidemiology and Clinical Research, St Vincent s Hospital, Sydney, New South Wales, Australia
    AIDS 14:959-69. 2000
    ..To determine the long-term T-lymphocyte response to highly active antiretroviral therapy (HAART) and to define predictors of the immunological response...
  30. ncbi request reprint Decimated or missing in action: CD4+ T cells as targets and effectors in the pathogenesis of primary HIV infection
    Anthony D Kelleher
    Immunovirology and Pathogenesis Program, National Centre in HIV Epidemiology and Clinical Research, University of North South Wales, Level 2, 376 Victoria Street, Darlinghurst, NSW, 2010, Australia
    Curr HIV/AIDS Rep 3:5-12. 2006
    ....
  31. pmc Characterization of the phenotypic and lymphokine profile associated with strong CD8+ anti-HIV-1 suppressor activity (CASA)
    J Wilkinson
    Centre for Immunology, St Vincent s Hospital, Sydney, Australia
    Clin Exp Immunol 127:145-50. 2002
    ..Strong CASA was therefore associated with rapidly replicating CD8+ T cells of the phenotype CD8+CD28+Ki67+ that expressed greater levels of IL-2 and the ligands RANTES and I-309...
  32. ncbi request reprint 4th International AIDS Society Conference on HIV Pathogenesis, Treatment and Prevention
    Lisa Maher
    National Centre in HIV Epidemiology and Clinical Research, University of New South Wales, Sydney, NSW, Australia
    Med J Aust 187:610-2. 2007
  33. ncbi request reprint Characterization of CD4(+) CTLs ex vivo
    Victor Appay
    Medical Research Council Human Immunology Unit, Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, United Kingdom
    J Immunol 168:5954-8. 2002
    ..The existence of CD4(+) cytotoxic T cells in vivo at relatively high levels in chronic viral infection suggests a role in the immune response...
  34. ncbi request reprint Comprehensive analyses of a unique HIV-1-infected nonprogressor reveal a complex association of immunobiological mechanisms in the context of replication-incompetent infection
    Bin Wang
    Retroviral Genetics Laboratory, Centre for Virus Research, Westmead Millennium Institute, Westmead Hospital, University of Sydney, Westmead, New South Wales 2145, Australia
    Virology 304:246-64. 2002
    ..Understanding how to induce these protective immune responses in other individuals could provide a major step forward in the design of effective immunotherapies or vaccines against HIV infection...
  35. ncbi request reprint First demonstration of a lack of viral sequence evolution in a nonprogressor, defining replication-incompetent HIV-1 infection
    Bin Wang
    Retroviral Genetics Laboratory, Center for Virus Research, Westmead Millennium Institute, Westmead, NSW 2145, Australia
    Virology 312:135-50. 2003
    ..Further study on the antigenic properties of this strain may assist in the development of HIV vaccines and therapeutics...
  36. ncbi request reprint Virologic determinants of success after structured treatment interruptions of antiretrovirals in acute HIV-1 infection
    Sharon R Lewin
    Infectious Diseases Unit, Alfred Hospital, Melbourne, Australia
    J Acquir Immune Defic Syndr 47:140-47. 2008
    ..Commencing ARVs during primary HIV-1 infection (PHI) may limit the size of the latent pool and lead to improved control of viral replication during structured treatment interruption (STI)...
  37. ncbi request reprint Upregulation of CTLA-4 by HIV-specific CD4+ T cells correlates with disease progression and defines a reversible immune dysfunction
    Daniel E Kaufmann
    Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Immunol 8:1246-54. 2007
    ..These data, indicating a reversible immunoregulatory pathway selectively associated with CD4(+) T cell dysfunction, provide a potential target for immunotherapy in HIV-infected patients...