Research Topics
| A R YungSummaryAffiliation: University of Melbourne Country: Australia Publications
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Detail Information
Publications
Young people at ultra high risk for psychosis: research from the PACE clinicAlison R Yung
Orygen Youth Health Research Centre, University of Melbourne, Parkville, Victoria, Australia
Rev Bras Psiquiatr 33:s143-60. 2011..A current controversy in the field is whether to include an adaption of the ultra high risk criteria (the attenuated psychosis syndrome) in the next version of the Diagnostic and Statistical Manual of Mental Disorders (Fifth Edition)...- The ultra high risk approach to define psychosis riskAlison R Yung
Orygen Youth Health Research Centre, Centre for Youth Mental Health, University of Melbourne, Australia
Curr Pharm Des 18:346-50. 2012..We will review here the mainstreams of the UHR paradigms focusing on the conceptual basis, potentials and limitations in current psychiatric research... 
The effectiveness of simple psychological and exercise interventions for high prevalence mental health problems in young people: a factorial randomised controlled trialAlexandra G Parker
Orygen Youth Health Research Centre, Centre for Youth Mental Health, University of Melbourne, Parkville, Victoria, Australia
Trials 12:76. 2011....- Study protocol: The development of a pilot study employing a randomised controlled design to investigate the feasibility and effects of a peer support program following discharge from a specialist first-episode psychosis treatment centreJo Robinson
Orygen Youth Health Research Centre, Centre for Youth Mental Health, Department of Psychiatry, University of Melbourne, Locked Bag 10, 35 Poplar Road, Parkville, Victoria 3052, Australia
BMC Psychiatry 10:37. 2010.... - Clinical utility of the Mood and Anxiety Symptom Questionnaire (MASQ) in a sample of young help-seekersJoe A Buckby
ORYGEN Research Centre, Melbourne, Australia
BMC Psychiatry 7:50. 2007..However, two recent studies have cautioned that the MASQ may show limited validity in clinical populations. The present study investigated the clinical utility of the MASQ in a clinical sample of adolescents and young adults... - A factor analytic investigation of the Tripartite model of affect in a clinical sample of young AustraliansJoe A Buckby
Orygen Youth Health Research Centre, Melbourne, Australia
BMC Psychiatry 8:79. 2008..The aim of the present study was to examine the validity of the Tripartite model using scale-level data from the MASQ and correlational and confirmatory factor analysis techniques... - Managing deliberate self-harm in young people: an evaluation of a training program developed for school welfare staff using a longitudinal research designJo Robinson
Department of Psychiatry, ORYGEN Research Centre, University of Melbourne, Parkville, Australia
BMC Psychiatry 8:75. 2008..The current study aimed to design, deliver and evaluate a training course specifically for school staff... - Study protocol: the development of a randomised controlled trial testing a postcard intervention designed to reduce suicide risk among young help-seekersJo Robinson
Orygen Youth Health Research Centre, Department of Psychiatry, University of Melbourne Locked Bag 10, Victoria, Australia
BMC Psychiatry 9:59. 2009..The aim of the study is to test a postcard intervention among people aged 15-24 who presented to mental health services but are not accepted, yet are at risk of suicide... 
Randomized controlled trial of interventions for young people at ultra high risk for psychosis: 6-month analysisAlison R Yung
ORYGEN Research Centre and University of Melbourne, Department of Psychiatry, 35 Poplar Rd, Parkville 3052, Victoria, Australia
J Clin Psychiatry 72:430-40. 2011..However, it is unclear which of these treatments are most effective, how long treatment should be given, and whether effects will be sustained over a prolonged period...- Public and private psychiatry: can they work together and is it worth the effort?Alison Yung
Department of Psychiatry, University of Melbourne, Parkville Victoria, Australia
Aust N Z J Psychiatry 39:67-73. 2005..It also examined possible barriers to collaboration and some possible solutions to the identified problems... - Association between psychotic experiences and depression in a clinical sample over 6 monthsAlison R Yung
ORYGEN Research Centre, 35 Poplar Rd Parkville 3052, Victoria, Australia
Schizophr Res 91:246-53. 2007..It is important to assess depression in those with PLEs and consider the need for treatment of the comorbid depressive syndrome. This may reduce the risk of worsening of PLEs and transition to psychotic disorder... - Risk factors for psychosis in an ultra high-risk group: psychopathology and clinical featuresAlison R Yung
Department of Psychiatry, University of Melbourne and ORYGEN Research Centre, Australia
Schizophr Res 67:131-42. 2004..This indicated prevention approach could be further developed and preventive strategies in the psychoses refined... - Should a "Risk Syndrome for Psychosis" be included in the DSMV?Alison R Yung
Orygen Youth Health Research Centre and Centre for Youth Mental Health, University of Melbourne, 35 Poplar Rd, Parkville, VIC 3052, Australia
Schizophr Res 120:7-15. 2010..Additionally, there are potential dangerous unintended consequences of the reification of this syndrome as a formal diagnosis. Thus we feel it is premature to justify inclusion of the RS in the DSM... - Psychotic-like experiences in nonpsychotic help-seekers: associations with distress, depression, and disabilityAlison R Yung
ORYGEN Research Centre, Parkville, Victoria, Australia
Schizophr Bull 32:352-9. 2006..Bizarre Experiences and Persecutory Ideas may be more malignant forms of psychotic symptoms, as they are associated with current disability, and may confer increased risk of development of full-blown psychotic disorder... - Mapping the onset of psychosis: the Comprehensive Assessment of At-Risk Mental StatesAlison R Yung
Department of Psychiatry, University of Melbourne, Melbourne, Australia
Aust N Z J Psychiatry 39:964-71. 2005..This paper describes the pilot evaluation of the CAARMS... - Validation of "prodromal" criteria to detect individuals at ultra high risk of psychosis: 2 year follow-upAlison R Yung
ORYGEN Research Centre and University of Melbourne, Department of Psychiatry, Parkville 3052, Victoria, Australia
Schizophr Res 105:10-7. 2008..Previous trials and biological research have been predicated on the view that certain "ultra high risk" (UHR) criteria detect "the prodrome", but there is a need to test the validity of these criteria... - Commentary: The schizophrenia prodrome: a high-risk conceptAlison R Yung
University of Melbourne, Department of Psychiatry and ORYGEN Youth Health (incorporating PACE and EPPIC, 35 Poplar Road, Parkville, 3052, Victoria, Australia
Schizophr Bull 29:859-65. 2003 - Testing the Ultra High Risk (prodromal) criteria for the prediction of psychosis in a clinical sample of young peopleAlison R Yung
ORYGEN Research Centre, 35 Poplar Rd Parkville 3052, Victoria, Australia
Schizophr Res 84:57-66. 2006..This may be a due to the sample being a more general one, not identified as possibly "prodromal". Other potential causes of this reduction in transition are also explored... - Psychotic-like experiences in a community sample of adolescents: implications for the continuum model of psychosis and prediction of schizophreniaAlison R Yung
Orygen Youth Health Research Centre and Department of Psychiatry, University of Melbourne, Parkville, Vic, Australia
Aust N Z J Psychiatry 43:118-28. 2009.... - The prevention of schizophreniaA R Yung
The Department of Psychiatry, The University of Melbourne, Victoria, Australia and ORYGEN Research Centre, Parkville, Victoria, Australia
Int Rev Psychiatry 19:633-46. 2007..Early intervention programmes which optimise the care of the first episode have been shown to produce better outcomes than routine management... - Young people at ultra high risk for psychosis: a research updateAlison R Yung
Orygen Youth Health Research Centre, Centre for Youth Mental Health, University of Melbourne, Parkville, Victoria, Australia
Early Interv Psychiatry 5:52-7. 2011..The validation of the ultra high risk criteria led to a series of intervention studies in this population. The aim of this paper is to provide an overview of ultra high risk research... - Management of early psychosis in a generic adult mental health serviceAlison R Yung
ORYGEN Research Centre, University of Melbourne Department of Psychiatry, 35 Poplar Road Parkville, Victoria 3052, Australia
Aust N Z J Psychiatry 37:429-36. 2003..A further aim was to compare treatment of early psychosis patients within this generic service with management of a similar group in a specialized early psychosis service... - PACE: a specialised service for young people at risk of psychotic disordersAlison R Yung
PACE Clinic, ORYGEN Youth Health, Melbourne, Vic, Australia
Med J Aust 187:S43-6. 2007.... - Declining transition rate in ultra high risk (prodromal) services: dilution or reduction of risk?Alison R Yung
ORYGEN Research Centre, 35 Poplar Road, Parkville 3052, Victoria, Australia
Schizophr Bull 33:673-81. 2007..Patients presenting to them need help. It may be that we need to aim to prevent a range of target syndromes... - Progressive gray matter reduction of the superior temporal gyrus during transition to psychosisTsutomu Takahashi
Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Australia
Arch Gen Psychiatry 66:366-76. 2009..It is unknown whether these progressive processes predate the onset of psychosis... - Road to full recovery: longitudinal relationship between symptomatic remission and psychosocial recovery in first-episode psychosis over 7.5 yearsM Alvarez-Jimenez
Centre for Youth Mental Health, The University of Melbourne, Melbourne, Australia
Psychol Med 42:595-606. 2012..This study sought to: (1) examine the relationships between FFR and symptom remission in FEP over 7.5 years; (2) test two different models of the interaction between both variables... - Experience of trauma and conversion to psychosis in an ultra-high-risk (prodromal) groupA Bechdolf
Department of Psychiatry, University of Melbourne, Australia
Acta Psychiatr Scand 121:377-84. 2010..We aimed to replicate a recent finding of high prevalence of trauma history in patients at 'ultra-high risk' (UHR) of psychotic disorder and to investigate whether trauma predicts conversion to psychosis in this population... - Stress and HPA-axis functioning in young people at ultra high risk for psychosisK N Thompson
PACE Clinic Orygen Research Centre, Locked Bag 10, Parkville 3052, Australia
J Psychiatr Res 41:561-9. 2007..These results indicate possible impairment in HPA-axis functioning in the early stages of psychotic illness, but further investigation of the relationships between these parameters is required... - Neurocognitive predictors of functional outcome two to 13 years after identification as ultra-high risk for psychosisA Lin
Orygen Youth Health Research Centre and Centre for Youth Mental Health, University of Melbourne, Australia
Schizophr Res 132:1-7. 2011..This longitudinal study aimed to investigate neurocognitive predictors of poor functional outcome in a group identified as ultra-high risk (UHR) for psychosis between two and 13 years prior... - Monitoring and care of young people at incipient risk of psychosisA R Yung
Early Psychosis Prevention and Intervention Centre, Parkville, Victoria, Australia
Schizophr Bull 22:283-303. 1996..Patients' needs, timing, and mode of treatment had to be considered. Preliminary data from the service's 20-month pilot phase are presented to help inform these issues... - Proton magnetic resonance spectroscopy in first episode psychosis and ultra high-risk individualsStephen J Wood
Melbourne Neuropsychiatry Centre, University of Melbourne and Sunshine Hospital, Melbourne, Australia
Schizophr Bull 29:831-43. 2003..This finding did not discriminate between those UHR individuals who later became psychotic and those who did not... - Neuroimaging and emerging psychotic disorders: the Melbourne ultra-high risk studiesC Pantelis
Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne, Royal Melbourne Hospital, Sunshine Hospital, 176 Furlong Road, St Albans, Victoria 3021, Australia
Int Rev Psychiatry 19:371-81. 2007..Further, active changes during transition to illness may present the potential to intervene and ameliorate these changes with potential benefit clinically... - Prediction of a single psychotic episode: a 7.5-year, prospective study in first-episode psychosisM Alvarez-Jimenez
Centre for Youth Mental Health, The University of Melbourne, Melbourne, Australia
Schizophr Res 125:236-46. 2011..5-year follow-up; and 2) to identify significant predictors for this subgroup independent of potential confounders... - The longitudinal association of adolescent dating violence with psychiatric disorders and functioningAdrienne Brown
ORYGEN Research Centre, University of Melbourne, Australia
J Interpers Violence 24:1964-79. 2009..These findings suggest that youth mental health services are well positioned not only to screen for dating violence but to intervene to ameliorate the mental health consequences of abuse and to prevent further violence... - Impact of co-occurring substance use on 6 month outcomes for young people seeking mental health treatmentKathryn D Baker
ORYGEN Research Centre, Department of Psychiatry, University of Melbourne, Parkville, Vic, Australia
Aust N Z J Psychiatry 41:896-902. 2007..The aim of the current study was to examine the impact of co-occurring substance use disorders (SUDs) on 6 month outcomes for young people seeking mental health treatment... - Prevalence of large cavum septi pellucidi in ultra high-risk individuals and patients with psychotic disordersTsutomu Takahashi
Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Victoria, Australia
Schizophr Res 105:236-44. 2008..These findings suggest that the CSP is not a neurodevelopmental marker of psychosis and cast doubt over the notion that it plays a major role in the neurobiology of psychosis... - A disturbed sense of self in the psychosis prodrome: linking phenomenology and neurobiologyB Nelson
Orygen Youth Health Research Centre, Department of Psychiatry, The University of Melbourne, Victoria, Australia
Neurosci Biobehav Rev 33:807-17. 2009..Further empirical work examining the relationship between neurobiological and phenomenological variables may be of value in identifying risk markers for psychosis onset... - Early identification and intervention in depressive disorders: towards a clinical staging modelS E Hetrick
ORYGEN Research Centre, Department of Psychiatry, University of Melbourne, Melbourne, Australia
Psychother Psychosom 77:263-70. 2008..As the onset often occurs in youth, there is a clear imperative for early identification and intervention to ameliorate, if not prevent, associated distress... - Identification of young people at risk of psychosis: validation of Personal Assessment and Crisis Evaluation Clinic intake criteriaL J Phillips
PACE Clinic, Parkville, Victoria, Australia
Aust N Z J Psychiatry 34:S164-9. 2000..To describe the development and validation of the criteria used at the Personal Assessment and Crisis Evaluation (PACE) Clinic to identify young people at 'ultra-high' risk of developing a psychotic disorder within a short follow-up period... - Insular cortex gray matter changes in individuals at ultra-high-risk of developing psychosisTsutomu Takahashi
Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Victoria, Australia
Schizophr Res 111:94-102. 2009..Whether these longitudinal changes are features of the disorder or related to treatment with antipsychotic medication remains to be determined... - Preventative mental health care: accessing the target populationL Phillips
PACE Clinic, MH SKY University of Melbourne, Parkville, Victoria, Australia
Aust N Z J Psychiatry 33:912-7. 1999..This descriptive paper summarises patterns of referral to one service providing clinical care for young people known to be at high risk of developing a psychotic illness... - Psychosis prediction: 12-month follow up of a high-risk ("prodromal") groupAlison R Yung
Department of Psychiatry, University of Melbourne, Parkville, Victoria, Australia
Schizophr Res 60:21-32. 2003..The findings support the development of more specific preventive strategies targeting the prodromal phase for some individuals at ultra high risk of schizophrenia... - Outcome of suicidal ideation and behavior in a young, help-seeking population over a 2-year periodE M Cosgrave
ORYGEN Research Center, Melbourne, Australia
Crisis 28:4-10. 2007..In conclusion, suicidality is prevalent among young people referred to psychiatric services. Even brief contact with services results in a reduction in suicidality over 2 years... - Ultra high risk (UHR) for psychosis criteria: are there different levels of risk for transition to psychosis?B Nelson
Orygen Youth Health Research Centre, Centre for Youth Mental Health, University of Melbourne, Melbourne, Victoria, Australia
Schizophr Res 125:62-8. 2011..The current study investigated this issue over a 6-month follow-up period. We hypothesised that the risk of transition would increase in the following order: Trait alone<APS alone < APS+Trait<BLIPS... - Effectiveness of early intervention in psychosisEoin Killackey
Department of Psychology, University of Melbourne, Australia
Curr Opin Psychiatry 20:121-5. 2007..This review examines recent developments in evaluating the effectiveness of early intervention. It considers identification and treatment of those at risk of psychosis, as well as interventions in the post-onset phase of illness... - The association between early cannabis use and psychotic-like experiences in a community adolescent sampleLeanne Hides
Orygen Youth Health Research Centre, Centre for Youth Mental Health, University of Melbourne, Parkville, Melbourne, Victoria 3052, Australia
Schizophr Res 112:130-5. 2009..These findings indicate that different levels of cannabis exposure were differentially associated with PLEs and highlight the need for early detection and treatment strategies for PLEs and cannabis use in adolescents... - Randomized controlled trial of interventions for young people at ultra-high risk of psychosis: study design and baseline characteristicsLisa J Phillips
Department of Psychology, University of Melbourne, Melbourne, Victoria 3010, Australia
Aust N Z J Psychiatry 43:818-29. 2009..Results of three clinical trials have been published that provide mixed support for the effectiveness of psychological and pharmacological interventions in preventing the onset of psychotic disorder... - Can clinicians predict psychosis in an ultra high risk group?Barnaby Nelson
Orygen Youth Health Research Centre, University of Melbourne, Parkville, Victoria, Australia
Aust N Z J Psychiatry 44:625-30. 2010..If not accurate it could mean that individuals are receiving antipsychotics unnecessarily. In this study, we investigated the predictive validity of clinical impression of whether ultra high risk patients would develop frank psychosis... - Caudate nucleus volume in individuals at ultra-high risk of psychosis: a cross-sectional magnetic resonance imaging studyKatrina L Hannan
Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Parkville, Victoria, Australia
Psychiatry Res 182:223-30. 2010..Future research should examine changes longitudinally together with analysis of shape to assess subregions of the caudate that connect with prefrontal cortex... - Hippocampal pathology in individuals at ultra-high risk for psychosis: a multi-modal magnetic resonance studyStephen J Wood
Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Parkville, Vic, Australia
Neuroimage 52:62-8. 2010..However, standard measures of neuroanatomical disturbance do not appear to be predictive of later transition, and instead are likely to be non-specific and common in cases that later develop a non-psychotic disorder... - Impairment of olfactory identification ability in individuals at ultra-high risk for psychosis who later develop schizophreniaWarrick J Brewer
Department of Psychiatry, University of Melbourne, Melbourne, Australia
Am J Psychiatry 160:1790-4. 2003..Previous investigation has revealed stable olfactory identification deficits in neuroleptic-naive patients experiencing a first episode of psychosis, but it is unknown if these deficits predate illness onset... - A clinical trials agenda for testing interventions in earlier stages of psychotic disordersPatrick D McGorry
University of Melbourne, Melbourne, Vic
Med J Aust 190:S33-6. 2009..It provides the opportunity for conducting large multisite clinical trials in young people with emerging major mental disorders... - Clinical staging: a heuristic and practical strategy for new research and better health and social outcomes for psychotic and related mood disordersPatrick D McGorry
Orygen Youth Health Centre for Youth Mental Health, University of Melbourne, Australia
Can J Psychiatry 55:486-97. 2010.... - Intervention in individuals at ultra-high risk for psychosis: a review and future directionsPatrick D McGorry
Centre for Youth Mental Health, Orygen Youth Health Research Centre, University of Melbourne, Victoria, Australia
J Clin Psychiatry 70:1206-12. 2009..This article reviews intervention research in the ultra-high-risk phase of psychotic disorders... - Brain changes during the onset of schizophrenia: implications for neurodevelopmental theoriesStephen J Wood
Melbourne Neuropsychiatry Centre, University of Melbourne and Melbourne Health, Melbourne, Vic
Med J Aust 190:S10-3. 2009..Although the cause of these changes is unclear, they challenge the conventional neurodevelopmental model of schizophrenia... - Adhesio interthalamica in individuals at high-risk for developing psychosis and patients with psychotic disordersTsutomu Takahashi
Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Victoria, Australia
Prog Neuropsychopharmacol Biol Psychiatry 32:1708-14. 2008.... - Generalized and specific cognitive performance in clinical high-risk cohorts: a review highlighting potential vulnerability markers for psychosisWarrick J Brewer
ORYGEN Research Centre and Early Psychosis Prevention and Intervention Centre, EPPIC, Department of Psychiatry, University of Melbourne, Australia
Schizophr Bull 32:538-55. 2006..Delineation of the relationship between specific cognitive ability and symptoms from data-driven approaches may improve our understanding of the role of cognition during psychosis onset... - Randomized controlled trial of interventions designed to reduce the risk of progression to first-episode psychosis in a clinical sample with subthreshold symptomsPatrick D McGorry
Early Psychosis Prevention and Intervention Centre, Melbourne, Australia
Arch Gen Psychiatry 59:921-8. 2002..However, only recently has it been possible to engage people in treatment during this phase... - Pituitary volume predicts future transition to psychosis in individuals at ultra-high risk of developing psychosisBelinda Garner
Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne, Royal Melbourne Hospital, Melbourne, Australia
Biol Psychiatry 58:417-23. 2005..032). CONCLUSIONS: The phase before the onset of psychosis is associated with a larger pituitary volume, suggesting activation of the HPA axis... - Hippocampal and anterior cingulate morphology in subjects at ultra-high-risk for psychosis: the role of family history of psychotic illnessStephen J Wood
Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne, National Neuroscience Facility, 161 Barry Street, Carlton South VIC 3053, Australia
Schizophr Res 75:295-301. 2005..Some appear to predate the illness and may be genetic in origin, while others are associated with the onset of the disorder... - Memory impairments identified in people at ultra-high risk for psychosis who later develop first-episode psychosisWarrick J Brewer
ORYGEN Research Centre, Melbourne, Australia
Am J Psychiatry 162:71-8. 2005..While cognitive deficits are frequently reported in psychotic disorders, it is unclear whether these impairments predate the onset of illness and to what extent they are predictive of later transition to psychosis... - The "close-in" or ultra high-risk model: a safe and effective strategy for research and clinical intervention in prepsychotic mental disorderPatrick D McGorry
ORYGEN Youth Health and ORYGEN Research Centre incorporating EPPIC and PACE, Parkville, Victoria, Australia
Schizophr Bull 29:771-90. 2003..Such research must be conducted in a logical and rigorous manner with the best designs possible, sensitive to input from consumers and caregivers and to ethical considerations... - Early intervention in psychosis: an overdue reformPatrick D McGorry
ORYGEN Research Centre, University of Melbourne, Department of Psychiatry, 35 Poplar Road Parkville 3052, Victoria, Australia
Aust N Z J Psychiatry 37:393-8. 2003..To discuss the rationale for early intervention in psychotic disorders and to explore why the widespread implementation of early intervention services has stalled... - Neuroanatomical abnormalities before and after onset of psychosis: a cross-sectional and longitudinal MRI comparisonChristos Pantelis
Cognitive Neuropsychiatry Research and Academic Unit, and Melbourne Neuropsychiatry Centre, Mental Health Programme, Department of Psychiatry, University of Melbourne and Sunshine Hospital, Victoria, Melbourne, Australia
Lancet 361:281-8. 2003..We investigated this issue with MRI to study people with prodromal symptoms who are at ultra high-risk for the development of psychosis... - Prediction and prevention of transition to psychosis in young people at incipient risk for schizophreniaLisa J Phillips
PACE Clinic, Parkville, Victoria, Australia
Am J Med Genet 114:929-37. 2002..Additionally, biological and psychological processes that have been proposed to underlie the development of illness have been investigated and potential preventive interventions have been evaluated... - Non-reduction in hippocampal volume is associated with higher risk of psychosisLisa J Phillips
PACE Clinic, Department of Psychiatry, University of Melbourne, 35 Poplar Road, Victoria 3052, Parkville, Australia
Schizophr Res 58:145-58. 2002..Alternatively, selection factors associated with the UHR cohort may have created a bias in the results. Replication of these results is required in other high-risk cohorts... - Cannabis use is not associated with the development of psychosis in an 'ultra' high-risk groupLisa J Phillips
Personal Assessment and Chris Evaluation PACE Clinic, Parkville, Victoria, Australia
Aust N Z J Psychiatry 36:800-6. 2002..The association between cannabis use and the development of a first psychotic episode was studied in a group of 100 young people identified as being at very high risk for the onset of psychosis... - Clinical staging of psychiatric disorders: a heuristic framework for choosing earlier, safer and more effective interventionsPatrick D McGorry
Department of Psychiatry, The University of Melbourne, Melbourne, Australia
Aust N Z J Psychiatry 40:616-22. 2006.... - Identifying the ultra-high risk (prodromal) population: evaluation of training workshops with mental health servicesBarnaby Nelson
ORYGEN Research Centre, Parkville, Vic, Australia
Aust N Z J Psychiatry 42:236-43. 2008.... - Back to the future: predicting and reshaping the course of psychotic disorderPatrick D McGorry
ORYGEN Research Centre and Department of Psychiatry, University of Melbourne, 35 Poplar Rd, Parkville, Victoria, Australia
Arch Gen Psychiatry 65:25-7. 2008 - Anatomic abnormalities of the anterior cingulate cortex before psychosis onset: an MRI study of ultra-high-risk individualsAlex Fornito
Department of Psychiatry, Melbourne Neuropsychiatry Centre, University of Melbourne, Carlton South, Victoria, Australia
Biol Psychiatry 64:758-65. 2008..In this study, we characterized prepsychotic ACC abnormalities in a sample of individuals at ultra-high-risk (UHR) for psychosis... - Cognitive decline following psychosis onset: data from the PACE clinicStephen J Wood
Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne, c o National Neuroscience Facility, 161 Barry Street, Carlton South, VIC 3053 Australia
Br J Psychiatry Suppl 51:s52-7. 2007..The origin of cognitive impairments in psychotic disorders is still unclear. Although some deficits are apparent prior to the onset of frank illness, it is unknown if they progress... - Medium term follow-up of a randomized controlled trial of interventions for young people at ultra high risk of psychosisLisa J Phillips
Department of Psychology, University of Melbourne, Vic, 3010 Australia
Schizophr Res 96:25-33. 2007.... - Early intervention in psychotic disorders: detection and treatment of the first episode and the critical early stagesPatrick D McGorry
ORYGEN Research Centre, Melbourne, Vic, Australia
Med J Aust 187:S8-10. 2007..Fully fledged, specialised early intervention services should be established, with full integration with local communities, as well as enhanced primary care systems focused on young people... - Distinguishing between anxiety and depression using the Mood and Anxiety Symptoms Questionnaire (MASQ)Joe A Buckby
ORYGEN Research Centre, Melbourne, Australia
Br J Clin Psychol 46:235-9. 2007..To examine the discriminant validity of the Mood and Anxiety Symptom Questionnaire (MASQ) in a sample of young help-seekers... - Clinical staging: a heuristic model for psychiatry and youth mental healthPatrick D McGorry
University of Melbourne, Melbourne, Vic, Australia
Med J Aust 187:S40-2. 2007..Young people with emerging mental and substance use disorders could be the main beneficiaries... - Does disturbance of self underlie social cognition deficits in schizophrenia and other psychotic disorders?Barnaby Nelson
ORYGEN Research Centre, University of Melbourne, Parkville, Victoria, Australia
Early Interv Psychiatry 3:83-93. 2009..This paper attempts to integrate a strand of cognitive research in psychotic disorders (specifically, social cognition research) with phenomenological accounts of schizophrenia and other psychotic disorders... - Motives for substance use among young people seeking mental health treatmentLeanne Hides
ORYGEN Research Centre, Department of Psychiatry, University of Melbourne, Melbourne, Victoria, Australia
Early Interv Psychiatry 2:188-94. 2008..To explore substance use motives among young people seeking mental health treatment... - Cost implications of specific and non-specific treatment for young persons at ultra high risk of developing a first episode of psychosisLisa J Phillips
Departments of Psychology and Psychiatry, University of Melbourne, Orygen Health Research Centre, Parkville, VIC 3010, Australia
Early Interv Psychiatry 3:28-34. 2009..This paper reports cost implications of providing psychological and pharmacological intervention for individuals at UHR for psychosis compared with minimal psychological treatment... - Can we detect psychotic-like experiences in the general population?B Nelson
Orygen Youth Health Research Centre, Centre for Youth Mental Health, University of Melbourne, Australia
Curr Pharm Des 18:376-85. 2012.... - Early-onset of symptoms predicts conversion to non-affective psychosis in ultra-high risk individualsG P Amminger
ORYGEN Research Centre incorporating the PACE Clinic, Department of Psychiatry, University of Melbourne, Australia
Schizophr Res 84:67-76. 2006..We examined if age of onset of psychiatric symptoms and/or sex predict conversion to non-affective or affective psychosis in individuals considered to be at ultra-high risk for schizophrenia... - Sustained attention in young people at high risk of psychosis does not predict transition to psychosisShona M Francey
PACE Clinic, ORYGEN Youth Health, Locked Bag 10, Parkville, 3052, Australia
Schizophr Res 79:127-36. 2005..These results support sustained attention as an indicator of vulnerability to psychosis, but suggest that CPT-IP performance does not help to predict transition to psychosis in an ultra high-risk group... - Psychotic symptoms with sexual content in the "ultra high risk" for psychosis population: frequency and association with sexual traumaAndrew Thompson
The PACE Clinic, ORYGEN Youth Health, Parkville, Melbourne, Australia
Psychiatry Res 177:84-91. 2010..17, P<0.01). This relationship remained significant when other traumatic experiences, PTSD diagnosis, age and sex were adjusted for. Further research into this relationship with regard to outcome and treatment is warranted... - Antibodies to infectious agents in individuals at ultra-high risk for psychosisG Paul Amminger
ORYGEN Research Centre, Department of Psychiatry, University of Melbourne, Australia
Biol Psychiatry 61:1215-7. 2007..While there is evidence that some cases of schizophrenia may be associated with microbial infections, the role of microbial agents has not been investigated in people with emerging psychosis... - Prepsychotic phase of schizophrenia and related disorders: recent progress and future opportunitiesLisa J Phillips
PACE Clinic, ORYGEN Research Centre, Locked Bag 10, Parkville 8052, Victoria, Australia
Br J Psychiatry Suppl 48:s33-44. 2005..Clinical and research focus has recently shifted from established psychotic disorders to first-episode psychosis and the prepsychotic phase of illness... - The phenomenological critique and self-disturbance: implications for ultra-high risk ("prodrome") researchBarnaby Nelson
ORYGEN Research Centre, 35 Poplar Road Locked Bag 10, Parkville, Victoria 3052, Australia
Schizophr Bull 34:381-92. 2008..The strong explanatory power and empirical findings to date invite further research into the role of self-disturbance as a phenotypic vulnerability marker for psychotic disorder... - Obstetric complications and transition to psychosis in an "ultra" high risk sampleYang Yun
Mental Health Center, West China Hospital, Sichuan University, 7 Xiaoxue Road, Chengdu, Sichuan Province 610044, China
Aust N Z J Psychiatry 39:460-6. 2005..In this study, the association between OCs and the development of psychotic disorder was studied in a group of 74 young people identified as being at very high risk for the first onset of psychosis... - Pituitary volume in psychosisCarmine M Pariante
Division of Psychological Medicine, Institute of Psychiatry, King s College London, UK
Br J Psychiatry 185:5-10. 2004..Patients with psychosis have activation of the hypothalamic-pituitary-adrenal (HPA) axis during the acute phase of the psychosis. Whether this has any morphological consequences for the pituitary gland is currently unknown... - Prediction of psychosis: setting the stageAlison R Yung
Br J Psychiatry Suppl 51:s1-8. 2007..More research is required in prediction, neurobiology and treatment... - The transition to psychosis: risk factors and brain changesStephen J Wood
Epidemiol Psichiatr Soc 13:137-40. 2004 - Early psychosis: where we've been, where we still have to goEoin Killackey
Epidemiol Psichiatr Soc 16:102-8. 2007..In order to continue to develop, while enjoying the benefits of being a mainstream intervention, early intervention must not stray too far from its reformist roots...