A R Yung

Summary

Affiliation: University of Melbourne
Country: Australia

Publications

  1. ncbi request reprint Young people at ultra high risk for psychosis: research from the PACE clinic
    Alison R Yung
    Orygen Youth Health Research Centre, University of Melbourne, Parkville, Victoria, Australia
    Rev Bras Psiquiatr 33:s143-60. 2011
  2. ncbi request reprint The ultra high risk approach to define psychosis risk
    Alison R Yung
    Orygen Youth Health Research Centre, Centre for Youth Mental Health, University of Melbourne, Australia
    Curr Pharm Des 18:346-50. 2012
  3. pmc The effectiveness of simple psychological and exercise interventions for high prevalence mental health problems in young people: a factorial randomised controlled trial
    Alexandra G Parker
    Orygen Youth Health Research Centre, Centre for Youth Mental Health, University of Melbourne, Parkville, Victoria, Australia
    Trials 12:76. 2011
  4. pmc Study protocol: The development of a pilot study employing a randomised controlled design to investigate the feasibility and effects of a peer support program following discharge from a specialist first-episode psychosis treatment centre
    Jo Robinson
    Orygen Youth Health Research Centre, Centre for Youth Mental Health, Department of Psychiatry, University of Melbourne, Locked Bag 10, 35 Poplar Road, Parkville, Victoria 3052, Australia
    BMC Psychiatry 10:37. 2010
  5. pmc Clinical utility of the Mood and Anxiety Symptom Questionnaire (MASQ) in a sample of young help-seekers
    Joe A Buckby
    ORYGEN Research Centre, Melbourne, Australia
    BMC Psychiatry 7:50. 2007
  6. pmc A factor analytic investigation of the Tripartite model of affect in a clinical sample of young Australians
    Joe A Buckby
    Orygen Youth Health Research Centre, Melbourne, Australia
    BMC Psychiatry 8:79. 2008
  7. pmc Managing deliberate self-harm in young people: an evaluation of a training program developed for school welfare staff using a longitudinal research design
    Jo Robinson
    Department of Psychiatry, ORYGEN Research Centre, University of Melbourne, Parkville, Australia
    BMC Psychiatry 8:75. 2008
  8. pmc Study protocol: the development of a randomised controlled trial testing a postcard intervention designed to reduce suicide risk among young help-seekers
    Jo Robinson
    Orygen Youth Health Research Centre, Department of Psychiatry, University of Melbourne Locked Bag 10, Victoria, Australia
    BMC Psychiatry 9:59. 2009
  9. doi request reprint Young people at ultra high risk for psychosis: a research update
    Alison R Yung
    Orygen Youth Health Research Centre, Centre for Youth Mental Health, University of Melbourne, Parkville, Victoria, Australia
    Early Interv Psychiatry 5:52-7. 2011
  10. ncbi request reprint Public and private psychiatry: can they work together and is it worth the effort?
    Alison Yung
    Department of Psychiatry, University of Melbourne, Parkville Victoria, Australia
    Aust N Z J Psychiatry 39:67-73. 2005

Detail Information

Publications95

  1. ncbi request reprint Young people at ultra high risk for psychosis: research from the PACE clinic
    Alison R Yung
    Orygen Youth Health Research Centre, University of Melbourne, Parkville, Victoria, Australia
    Rev Bras Psiquiatr 33:s143-60. 2011
    ..A current controversy in the field is whether to include an adaption of the ultra high risk criteria (the attenuated psychosis syndrome) in the next version of the Diagnostic and Statistical Manual of Mental Disorders (Fifth Edition)...
  2. ncbi request reprint The ultra high risk approach to define psychosis risk
    Alison R Yung
    Orygen Youth Health Research Centre, Centre for Youth Mental Health, University of Melbourne, Australia
    Curr Pharm Des 18:346-50. 2012
    ..We will review here the mainstreams of the UHR paradigms focusing on the conceptual basis, potentials and limitations in current psychiatric research...
  3. pmc The effectiveness of simple psychological and exercise interventions for high prevalence mental health problems in young people: a factorial randomised controlled trial
    Alexandra G Parker
    Orygen Youth Health Research Centre, Centre for Youth Mental Health, University of Melbourne, Parkville, Victoria, Australia
    Trials 12:76. 2011
    ....
  4. pmc Study protocol: The development of a pilot study employing a randomised controlled design to investigate the feasibility and effects of a peer support program following discharge from a specialist first-episode psychosis treatment centre
    Jo Robinson
    Orygen Youth Health Research Centre, Centre for Youth Mental Health, Department of Psychiatry, University of Melbourne, Locked Bag 10, 35 Poplar Road, Parkville, Victoria 3052, Australia
    BMC Psychiatry 10:37. 2010
    ....
  5. pmc Clinical utility of the Mood and Anxiety Symptom Questionnaire (MASQ) in a sample of young help-seekers
    Joe A Buckby
    ORYGEN Research Centre, Melbourne, Australia
    BMC Psychiatry 7:50. 2007
    ..However, two recent studies have cautioned that the MASQ may show limited validity in clinical populations. The present study investigated the clinical utility of the MASQ in a clinical sample of adolescents and young adults...
  6. pmc A factor analytic investigation of the Tripartite model of affect in a clinical sample of young Australians
    Joe A Buckby
    Orygen Youth Health Research Centre, Melbourne, Australia
    BMC Psychiatry 8:79. 2008
    ..The aim of the present study was to examine the validity of the Tripartite model using scale-level data from the MASQ and correlational and confirmatory factor analysis techniques...
  7. pmc Managing deliberate self-harm in young people: an evaluation of a training program developed for school welfare staff using a longitudinal research design
    Jo Robinson
    Department of Psychiatry, ORYGEN Research Centre, University of Melbourne, Parkville, Australia
    BMC Psychiatry 8:75. 2008
    ..The current study aimed to design, deliver and evaluate a training course specifically for school staff...
  8. pmc Study protocol: the development of a randomised controlled trial testing a postcard intervention designed to reduce suicide risk among young help-seekers
    Jo Robinson
    Orygen Youth Health Research Centre, Department of Psychiatry, University of Melbourne Locked Bag 10, Victoria, Australia
    BMC Psychiatry 9:59. 2009
    ..The aim of the study is to test a postcard intervention among people aged 15-24 who presented to mental health services but are not accepted, yet are at risk of suicide...
  9. doi request reprint Young people at ultra high risk for psychosis: a research update
    Alison R Yung
    Orygen Youth Health Research Centre, Centre for Youth Mental Health, University of Melbourne, Parkville, Victoria, Australia
    Early Interv Psychiatry 5:52-7. 2011
    ..The validation of the ultra high risk criteria led to a series of intervention studies in this population. The aim of this paper is to provide an overview of ultra high risk research...
  10. ncbi request reprint Public and private psychiatry: can they work together and is it worth the effort?
    Alison Yung
    Department of Psychiatry, University of Melbourne, Parkville Victoria, Australia
    Aust N Z J Psychiatry 39:67-73. 2005
    ..It also examined possible barriers to collaboration and some possible solutions to the identified problems...
  11. pmc Declining transition rate in ultra high risk (prodromal) services: dilution or reduction of risk?
    Alison R Yung
    ORYGEN Research Centre, 35 Poplar Road, Parkville 3052, Victoria, Australia
    Schizophr Bull 33:673-81. 2007
    ..Patients presenting to them need help. It may be that we need to aim to prevent a range of target syndromes...
  12. pmc Psychotic-like experiences in nonpsychotic help-seekers: associations with distress, depression, and disability
    Alison R Yung
    ORYGEN Research Centre, Parkville, Victoria, Australia
    Schizophr Bull 32:352-9. 2006
    ..Bizarre Experiences and Persecutory Ideas may be more malignant forms of psychotic symptoms, as they are associated with current disability, and may confer increased risk of development of full-blown psychotic disorder...
  13. ncbi request reprint Mapping the onset of psychosis: the Comprehensive Assessment of At-Risk Mental States
    Alison R Yung
    Department of Psychiatry, University of Melbourne, Melbourne, Australia
    Aust N Z J Psychiatry 39:964-71. 2005
    ..This paper describes the pilot evaluation of the CAARMS...
  14. ncbi request reprint Association between psychotic experiences and depression in a clinical sample over 6 months
    Alison R Yung
    ORYGEN Research Centre, 35 Poplar Rd Parkville 3052, Victoria, Australia
    Schizophr Res 91:246-53. 2007
    ..It is important to assess depression in those with PLEs and consider the need for treatment of the comorbid depressive syndrome. This may reduce the risk of worsening of PLEs and transition to psychotic disorder...
  15. ncbi request reprint Commentary: The schizophrenia prodrome: a high-risk concept
    Alison R Yung
    University of Melbourne, Department of Psychiatry and ORYGEN Youth Health incorporating PACE and EPPIC, 35 Poplar Road, Parkville, 3052, Victoria, Australia
    Schizophr Bull 29:859-65. 2003
  16. ncbi request reprint PACE: a specialised service for young people at risk of psychotic disorders
    Alison R Yung
    PACE Clinic, ORYGEN Youth Health, Melbourne, Vic, Australia
    Med J Aust 187:S43-6. 2007
    ....
  17. doi request reprint Validation of "prodromal" criteria to detect individuals at ultra high risk of psychosis: 2 year follow-up
    Alison R Yung
    ORYGEN Research Centre and University of Melbourne, Department of Psychiatry, Parkville 3052, Victoria, Australia
    Schizophr Res 105:10-7. 2008
    ..Previous trials and biological research have been predicated on the view that certain "ultra high risk" (UHR) criteria detect "the prodrome", but there is a need to test the validity of these criteria...
  18. doi request reprint Psychotic-like experiences in a community sample of adolescents: implications for the continuum model of psychosis and prediction of schizophrenia
    Alison R Yung
    Orygen Youth Health Research Centre and Department of Psychiatry, University of Melbourne, Parkville, Vic, Australia
    Aust N Z J Psychiatry 43:118-28. 2009
    ....
  19. ncbi request reprint The prevention of schizophrenia
    A R Yung
    The Department of Psychiatry, The University of Melbourne, Victoria, Australia and ORYGEN Research Centre, Parkville, Victoria, Australia
    Int Rev Psychiatry 19:633-46. 2007
    ..Early intervention programmes which optimise the care of the first episode have been shown to produce better outcomes than routine management...
  20. doi request reprint Randomized controlled trial of interventions for young people at ultra high risk for psychosis: 6-month analysis
    Alison R Yung
    ORYGEN Research Centre and University of Melbourne, Department of Psychiatry, 35 Poplar Rd, Parkville 3052, Victoria, Australia
    J Clin Psychiatry 72:430-40. 2011
    ..However, it is unclear which of these treatments are most effective, how long treatment should be given, and whether effects will be sustained over a prolonged period...
  21. doi request reprint Should a "Risk Syndrome for Psychosis" be included in the DSMV?
    Alison R Yung
    Orygen Youth Health Research Centre and Centre for Youth Mental Health, University of Melbourne, 35 Poplar Rd, Parkville, VIC 3052, Australia
    Schizophr Res 120:7-15. 2010
    ..Additionally, there are potential dangerous unintended consequences of the reification of this syndrome as a formal diagnosis. Thus we feel it is premature to justify inclusion of the RS in the DSM...
  22. ncbi request reprint Management of early psychosis in a generic adult mental health service
    Alison R Yung
    ORYGEN Research Centre, University of Melbourne Department of Psychiatry, 35 Poplar Road Parkville, Victoria 3052, Australia
    Aust N Z J Psychiatry 37:429-36. 2003
    ..A further aim was to compare treatment of early psychosis patients within this generic service with management of a similar group in a specialized early psychosis service...
  23. ncbi request reprint Risk factors for psychosis in an ultra high-risk group: psychopathology and clinical features
    Alison R Yung
    Department of Psychiatry, University of Melbourne and ORYGEN Research Centre, Australia
    Schizophr Res 67:131-42. 2004
    ..This indicated prevention approach could be further developed and preventive strategies in the psychoses refined...
  24. ncbi request reprint Testing the Ultra High Risk (prodromal) criteria for the prediction of psychosis in a clinical sample of young people
    Alison R Yung
    ORYGEN Research Centre, 35 Poplar Rd Parkville 3052, Victoria, Australia
    Schizophr Res 84:57-66. 2006
    ..This may be a due to the sample being a more general one, not identified as possibly "prodromal". Other potential causes of this reduction in transition are also explored...
  25. doi request reprint Progressive gray matter reduction of the superior temporal gyrus during transition to psychosis
    Tsutomu Takahashi
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Australia
    Arch Gen Psychiatry 66:366-76. 2009
    ..It is unknown whether these progressive processes predate the onset of psychosis...
  26. doi request reprint Road to full recovery: longitudinal relationship between symptomatic remission and psychosocial recovery in first-episode psychosis over 7.5 years
    M Alvarez-Jimenez
    Centre for Youth Mental Health, The University of Melbourne, Melbourne, Australia
    Psychol Med 42:595-606. 2012
    ..This study sought to: (1) examine the relationships between FFR and symptom remission in FEP over 7.5 years; (2) test two different models of the interaction between both variables...
  27. ncbi request reprint Experience of trauma and conversion to psychosis in an ultra-high-risk (prodromal) group
    A Bechdolf
    Department of Psychiatry, University of Melbourne, Australia
    Acta Psychiatr Scand 121:377-84. 2010
    ..We aimed to replicate a recent finding of high prevalence of trauma history in patients at 'ultra-high risk' (UHR) of psychotic disorder and to investigate whether trauma predicts conversion to psychosis in this population...
  28. ncbi request reprint Neurocognitive predictors of transition to psychosis: medium- to long-term findings from a sample at ultra-high risk for psychosis
    A Lin
    Orygen Youth Health Research Centre and Centre for Youth Mental Health, University of Melbourne, Australia
    Psychol Med 43:2349-60. 2013
    ....
  29. ncbi request reprint Stress and HPA-axis functioning in young people at ultra high risk for psychosis
    K N Thompson
    PACE Clinic Orygen Research Centre, Locked Bag 10, Parkville 3052, Australia
    J Psychiatr Res 41:561-9. 2007
    ..These results indicate possible impairment in HPA-axis functioning in the early stages of psychotic illness, but further investigation of the relationships between these parameters is required...
  30. doi request reprint Neurocognitive predictors of functional outcome two to 13 years after identification as ultra-high risk for psychosis
    A Lin
    Orygen Youth Health Research Centre and Centre for Youth Mental Health, University of Melbourne, Australia
    Schizophr Res 132:1-7. 2011
    ..This longitudinal study aimed to investigate neurocognitive predictors of poor functional outcome in a group identified as ultra-high risk (UHR) for psychosis between two and 13 years prior...
  31. ncbi request reprint Monitoring and care of young people at incipient risk of psychosis
    A R Yung
    Early Psychosis Prevention and Intervention Centre, Parkville, Victoria, Australia
    Schizophr Bull 22:283-303. 1996
    ..Patients' needs, timing, and mode of treatment had to be considered. Preliminary data from the service's 20-month pilot phase are presented to help inform these issues...
  32. ncbi request reprint Proton magnetic resonance spectroscopy in first episode psychosis and ultra high-risk individuals
    Stephen J Wood
    Melbourne Neuropsychiatry Centre, University of Melbourne and Sunshine Hospital, Melbourne, Australia
    Schizophr Bull 29:831-43. 2003
    ..This finding did not discriminate between those UHR individuals who later became psychotic and those who did not...
  33. doi request reprint The relationship between coping and subclinical psychotic experiences in adolescents from the general population--a longitudinal study
    A Lin
    Orygen Youth Health Research Centre and Centre for Youth Mental Health, University of Melbourne, Victoria, Australia
    Psychol Med 41:2535-46. 2011
    ..Both coping style and the degree of persistence of psychotic experiences may play a role in the progression to clinical psychotic disorder, but little is known about the causal relationship between the two...
  34. pmc Effects of NRG1 and DAOA genetic variation on transition to psychosis in individuals at ultra-high risk for psychosis
    C A Bousman
    Melbourne Brain Centre, Department of Psychiatry, The University of Melbourne, Parkville, Vic, Australia
    Transl Psychiatry 3:e251. 2013
    ..None of the assessed DAOA htSNPs were associated with transition. Our findings suggest NRG1 genetic variation may improve our ability to identify UHR individuals at risk for transition to psychosis...
  35. ncbi request reprint Neuroimaging and emerging psychotic disorders: the Melbourne ultra-high risk studies
    C Pantelis
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne, Royal Melbourne Hospital, Sunshine Hospital, 176 Furlong Road, St Albans, Victoria 3021, Australia
    Int Rev Psychiatry 19:371-81. 2007
    ..Further, active changes during transition to illness may present the potential to intervene and ameliorate these changes with potential benefit clinically...
  36. doi request reprint Prediction of a single psychotic episode: a 7.5-year, prospective study in first-episode psychosis
    M Alvarez-Jimenez
    Centre for Youth Mental Health, The University of Melbourne, Melbourne, Australia
    Schizophr Res 125:236-46. 2011
    ..5-year follow-up; and 2) to identify significant predictors for this subgroup independent of potential confounders...
  37. doi request reprint Prevalence of large cavum septi pellucidi in ultra high-risk individuals and patients with psychotic disorders
    Tsutomu Takahashi
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Victoria, Australia
    Schizophr Res 105:236-44. 2008
    ..These findings suggest that the CSP is not a neurodevelopmental marker of psychosis and cast doubt over the notion that it plays a major role in the neurobiology of psychosis...
  38. doi request reprint The longitudinal association of adolescent dating violence with psychiatric disorders and functioning
    Adrienne Brown
    ORYGEN Research Centre, University of Melbourne, Australia
    J Interpers Violence 24:1964-79. 2009
    ..These findings suggest that youth mental health services are well positioned not only to screen for dating violence but to intervene to ameliorate the mental health consequences of abuse and to prevent further violence...
  39. ncbi request reprint Impact of co-occurring substance use on 6 month outcomes for young people seeking mental health treatment
    Kathryn D Baker
    ORYGEN Research Centre, Department of Psychiatry, University of Melbourne, Parkville, Vic, Australia
    Aust N Z J Psychiatry 41:896-902. 2007
    ..The aim of the current study was to examine the impact of co-occurring substance use disorders (SUDs) on 6 month outcomes for young people seeking mental health treatment...
  40. ncbi request reprint Early identification and intervention in depressive disorders: towards a clinical staging model
    S E Hetrick
    ORYGEN Research Centre, Department of Psychiatry, University of Melbourne, Melbourne, Australia
    Psychother Psychosom 77:263-70. 2008
    ..As the onset often occurs in youth, there is a clear imperative for early identification and intervention to ameliorate, if not prevent, associated distress...
  41. doi request reprint A disturbed sense of self in the psychosis prodrome: linking phenomenology and neurobiology
    B Nelson
    Orygen Youth Health Research Centre, Department of Psychiatry, The University of Melbourne, Victoria, Australia
    Neurosci Biobehav Rev 33:807-17. 2009
    ..Further empirical work examining the relationship between neurobiological and phenomenological variables may be of value in identifying risk markers for psychosis onset...
  42. ncbi request reprint Identification of young people at risk of psychosis: validation of Personal Assessment and Crisis Evaluation Clinic intake criteria
    L J Phillips
    PACE Clinic, Parkville, Victoria, Australia
    Aust N Z J Psychiatry 34:S164-9. 2000
    ..To describe the development and validation of the criteria used at the Personal Assessment and Crisis Evaluation (PACE) Clinic to identify young people at 'ultra-high' risk of developing a psychotic disorder within a short follow-up period...
  43. doi request reprint Insular cortex gray matter changes in individuals at ultra-high-risk of developing psychosis
    Tsutomu Takahashi
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Victoria, Australia
    Schizophr Res 111:94-102. 2009
    ..Whether these longitudinal changes are features of the disorder or related to treatment with antipsychotic medication remains to be determined...
  44. ncbi request reprint Preventative mental health care: accessing the target population
    L Phillips
    PACE Clinic, MH SKY University of Melbourne, Parkville, Victoria, Australia
    Aust N Z J Psychiatry 33:912-7. 1999
    ..This descriptive paper summarises patterns of referral to one service providing clinical care for young people known to be at high risk of developing a psychotic illness...
  45. ncbi request reprint Psychosis prediction: 12-month follow up of a high-risk ("prodromal") group
    Alison R Yung
    Department of Psychiatry, University of Melbourne, Parkville, Victoria, Australia
    Schizophr Res 60:21-32. 2003
    ..The findings support the development of more specific preventive strategies targeting the prodromal phase for some individuals at ultra high risk of schizophrenia...
  46. doi request reprint Ultra high risk (UHR) for psychosis criteria: are there different levels of risk for transition to psychosis?
    B Nelson
    Orygen Youth Health Research Centre, Centre for Youth Mental Health, University of Melbourne, Melbourne, Victoria, Australia
    Schizophr Res 125:62-8. 2011
    ..The current study investigated this issue over a 6-month follow-up period. We hypothesised that the risk of transition would increase in the following order: Trait alone<APS alone < APS+Trait<BLIPS...
  47. ncbi request reprint Outcome of suicidal ideation and behavior in a young, help-seeking population over a 2-year period
    E M Cosgrave
    ORYGEN Research Center, Melbourne, Australia
    Crisis 28:4-10. 2007
    ..In conclusion, suicidality is prevalent among young people referred to psychiatric services. Even brief contact with services results in a reduction in suicidality over 2 years...
  48. ncbi request reprint Cognitive deficits in youth with familial and clinical high risk to psychosis: a systematic review and meta-analysis
    E Bora
    Department of Psychiatry, Melbourne Neuropsychiatry Centre, The University of Melbourne and Melbourne Health, Melbourne, Vic, Australia
    Acta Psychiatr Scand 130:1-15. 2014
    ..Studies at-risk adolescents and young adults are likely to provide information about cognitive deficits that predate the onset of the illness...
  49. ncbi request reprint Brain changes during the onset of schizophrenia: implications for neurodevelopmental theories
    Stephen J Wood
    Melbourne Neuropsychiatry Centre, University of Melbourne and Melbourne Health, Melbourne, Vic
    Med J Aust 190:S10-3. 2009
    ..Although the cause of these changes is unclear, they challenge the conventional neurodevelopmental model of schizophrenia...
  50. ncbi request reprint The association between early cannabis use and psychotic-like experiences in a community adolescent sample
    Leanne Hides
    Orygen Youth Health Research Centre, Centre for Youth Mental Health, University of Melbourne, Parkville, Melbourne, Victoria 3052, Australia
    Schizophr Res 112:130-5. 2009
    ..These findings indicate that different levels of cannabis exposure were differentially associated with PLEs and highlight the need for early detection and treatment strategies for PLEs and cannabis use in adolescents...
  51. ncbi request reprint Can clinicians predict psychosis in an ultra high risk group?
    Barnaby Nelson
    Orygen Youth Health Research Centre, University of Melbourne, Parkville, Victoria, Australia
    Aust N Z J Psychiatry 44:625-30. 2010
    ..If not accurate it could mean that individuals are receiving antipsychotics unnecessarily. In this study, we investigated the predictive validity of clinical impression of whether ultra high risk patients would develop frank psychosis...
  52. ncbi request reprint Impairment of olfactory identification ability in individuals at ultra-high risk for psychosis who later develop schizophrenia
    Warrick J Brewer
    Department of Psychiatry, University of Melbourne, Melbourne, Australia
    Am J Psychiatry 160:1790-4. 2003
    ..Previous investigation has revealed stable olfactory identification deficits in neuroleptic-naive patients experiencing a first episode of psychosis, but it is unknown if these deficits predate illness onset...
  53. ncbi request reprint Intervention in individuals at ultra-high risk for psychosis: a review and future directions
    Patrick D McGorry
    Centre for Youth Mental Health, Orygen Youth Health Research Centre, University of Melbourne, Victoria, Australia
    J Clin Psychiatry 70:1206-12. 2009
    ..This article reviews intervention research in the ultra-high-risk phase of psychotic disorders...
  54. doi request reprint Randomized controlled trial of interventions for young people at ultra-high risk of psychosis: study design and baseline characteristics
    Lisa J Phillips
    Department of Psychology, University of Melbourne, Melbourne, Victoria 3010, Australia
    Aust N Z J Psychiatry 43:818-29. 2009
    ..Results of three clinical trials have been published that provide mixed support for the effectiveness of psychological and pharmacological interventions in preventing the onset of psychotic disorder...
  55. ncbi request reprint Hippocampal pathology in individuals at ultra-high risk for psychosis: a multi-modal magnetic resonance study
    Stephen J Wood
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Parkville, Vic, Australia
    Neuroimage 52:62-8. 2010
    ..However, standard measures of neuroanatomical disturbance do not appear to be predictive of later transition, and instead are likely to be non-specific and common in cases that later develop a non-psychotic disorder...
  56. ncbi request reprint Clinical staging: a heuristic and practical strategy for new research and better health and social outcomes for psychotic and related mood disorders
    Patrick D McGorry
    Orygen Youth Health Centre for Youth Mental Health, University of Melbourne, Australia
    Can J Psychiatry 55:486-97. 2010
    ....
  57. doi request reprint Caudate nucleus volume in individuals at ultra-high risk of psychosis: a cross-sectional magnetic resonance imaging study
    Katrina L Hannan
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Parkville, Victoria, Australia
    Psychiatry Res 182:223-30. 2010
    ..Future research should examine changes longitudinally together with analysis of shape to assess subregions of the caudate that connect with prefrontal cortex...
  58. ncbi request reprint A clinical trials agenda for testing interventions in earlier stages of psychotic disorders
    Patrick D McGorry
    University of Melbourne, Melbourne, Vic
    Med J Aust 190:S33-6. 2009
    ..It provides the opportunity for conducting large multisite clinical trials in young people with emerging major mental disorders...
  59. ncbi request reprint Non-reduction in hippocampal volume is associated with higher risk of psychosis
    Lisa J Phillips
    PACE Clinic, Department of Psychiatry, University of Melbourne, 35 Poplar Road, Victoria 3052, Parkville, Australia
    Schizophr Res 58:145-58. 2002
    ..Alternatively, selection factors associated with the UHR cohort may have created a bias in the results. Replication of these results is required in other high-risk cohorts...
  60. ncbi request reprint Effectiveness of early intervention in psychosis
    Eoin Killackey
    Department of Psychology, University of Melbourne, Australia
    Curr Opin Psychiatry 20:121-5. 2007
    ..This review examines recent developments in evaluating the effectiveness of early intervention. It considers identification and treatment of those at risk of psychosis, as well as interventions in the post-onset phase of illness...
  61. pmc The "close-in" or ultra high-risk model: a safe and effective strategy for research and clinical intervention in prepsychotic mental disorder
    Patrick D McGorry
    ORYGEN Youth Health and ORYGEN Research Centre incorporating EPPIC and PACE, Parkville, Victoria, Australia
    Schizophr Bull 29:771-90. 2003
    ..Such research must be conducted in a logical and rigorous manner with the best designs possible, sensitive to input from consumers and caregivers and to ethical considerations...
  62. ncbi request reprint Clinical staging of psychiatric disorders: a heuristic framework for choosing earlier, safer and more effective interventions
    Patrick D McGorry
    Department of Psychiatry, The University of Melbourne, Melbourne, Australia
    Aust N Z J Psychiatry 40:616-22. 2006
    ....
  63. pmc Generalized and specific cognitive performance in clinical high-risk cohorts: a review highlighting potential vulnerability markers for psychosis
    Warrick J Brewer
    ORYGEN Research Centre and Early Psychosis Prevention and Intervention Centre, EPPIC, Department of Psychiatry, University of Melbourne, Australia
    Schizophr Bull 32:538-55. 2006
    ..Delineation of the relationship between specific cognitive ability and symptoms from data-driven approaches may improve our understanding of the role of cognition during psychosis onset...
  64. ncbi request reprint Memory impairments identified in people at ultra-high risk for psychosis who later develop first-episode psychosis
    Warrick J Brewer
    ORYGEN Research Centre, Melbourne, Australia
    Am J Psychiatry 162:71-8. 2005
    ..While cognitive deficits are frequently reported in psychotic disorders, it is unclear whether these impairments predate the onset of illness and to what extent they are predictive of later transition to psychosis...
  65. ncbi request reprint Prediction and prevention of transition to psychosis in young people at incipient risk for schizophrenia
    Lisa J Phillips
    PACE Clinic, Parkville, Victoria, Australia
    Am J Med Genet 114:929-37. 2002
    ..Additionally, biological and psychological processes that have been proposed to underlie the development of illness have been investigated and potential preventive interventions have been evaluated...
  66. ncbi request reprint Neuroanatomical abnormalities before and after onset of psychosis: a cross-sectional and longitudinal MRI comparison
    Christos Pantelis
    Cognitive Neuropsychiatry Research and Academic Unit, and Melbourne Neuropsychiatry Centre, Mental Health Programme, Department of Psychiatry, University of Melbourne and Sunshine Hospital, Victoria, Melbourne, Australia
    Lancet 361:281-8. 2003
    ..We investigated this issue with MRI to study people with prodromal symptoms who are at ultra high-risk for the development of psychosis...
  67. ncbi request reprint Pituitary volume predicts future transition to psychosis in individuals at ultra-high risk of developing psychosis
    Belinda Garner
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne, Royal Melbourne Hospital, Melbourne, Australia
    Biol Psychiatry 58:417-23. 2005
    ..We examined pituitary volume before the onset of psychosis in subjects who were at ultra-high risk (UHR) for developing psychosis...
  68. ncbi request reprint Early intervention in psychosis: an overdue reform
    Patrick D McGorry
    ORYGEN Research Centre, University of Melbourne, Department of Psychiatry, 35 Poplar Road Parkville 3052, Victoria, Australia
    Aust N Z J Psychiatry 37:393-8. 2003
    ..To discuss the rationale for early intervention in psychotic disorders and to explore why the widespread implementation of early intervention services has stalled...
  69. ncbi request reprint Medium term follow-up of a randomized controlled trial of interventions for young people at ultra high risk of psychosis
    Lisa J Phillips
    Department of Psychology, University of Melbourne, Vic, 3010 Australia
    Schizophr Res 96:25-33. 2007
    ....
  70. ncbi request reprint Cannabis use is not associated with the development of psychosis in an 'ultra' high-risk group
    Lisa J Phillips
    Personal Assessment and Chris Evaluation PACE Clinic, Parkville, Victoria, Australia
    Aust N Z J Psychiatry 36:800-6. 2002
    ..The association between cannabis use and the development of a first psychotic episode was studied in a group of 100 young people identified as being at very high risk for the onset of psychosis...
  71. doi request reprint Adhesio interthalamica in individuals at high-risk for developing psychosis and patients with psychotic disorders
    Tsutomu Takahashi
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Victoria, Australia
    Prog Neuropsychopharmacol Biol Psychiatry 32:1708-14. 2008
    ....
  72. doi request reprint Anatomic abnormalities of the anterior cingulate cortex before psychosis onset: an MRI study of ultra-high-risk individuals
    Alex Fornito
    Department of Psychiatry, Melbourne Neuropsychiatry Centre, University of Melbourne, Carlton South, Victoria, Australia
    Biol Psychiatry 64:758-65. 2008
    ..In this study, we characterized prepsychotic ACC abnormalities in a sample of individuals at ultra-high-risk (UHR) for psychosis...
  73. doi request reprint Identifying the ultra-high risk (prodromal) population: evaluation of training workshops with mental health services
    Barnaby Nelson
    ORYGEN Research Centre, Parkville, Vic, Australia
    Aust N Z J Psychiatry 42:236-43. 2008
    ....
  74. doi request reprint Back to the future: predicting and reshaping the course of psychotic disorder
    Patrick D McGorry
    ORYGEN Research Centre and Department of Psychiatry, University of Melbourne, 35 Poplar Rd, Parkville, Victoria, Australia
    Arch Gen Psychiatry 65:25-7. 2008
  75. doi request reprint Cognitive decline following psychosis onset: data from the PACE clinic
    Stephen J Wood
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne, c o National Neuroscience Facility, 161 Barry Street, Carlton South, VIC 3053 Australia
    Br J Psychiatry Suppl 51:s52-7. 2007
    ..The origin of cognitive impairments in psychotic disorders is still unclear. Although some deficits are apparent prior to the onset of frank illness, it is unknown if they progress...
  76. ncbi request reprint Distinguishing between anxiety and depression using the Mood and Anxiety Symptoms Questionnaire (MASQ)
    Joe A Buckby
    ORYGEN Research Centre, Melbourne, Australia
    Br J Clin Psychol 46:235-9. 2007
    ..To examine the discriminant validity of the Mood and Anxiety Symptom Questionnaire (MASQ) in a sample of young help-seekers...
  77. ncbi request reprint Early intervention in psychotic disorders: detection and treatment of the first episode and the critical early stages
    Patrick D McGorry
    ORYGEN Research Centre, Melbourne, Vic, Australia
    Med J Aust 187:S8-10. 2007
    ..Fully fledged, specialised early intervention services should be established, with full integration with local communities, as well as enhanced primary care systems focused on young people...
  78. ncbi request reprint Clinical staging: a heuristic model for psychiatry and youth mental health
    Patrick D McGorry
    University of Melbourne, Melbourne, Vic, Australia
    Med J Aust 187:S40-2. 2007
    ..Young people with emerging mental and substance use disorders could be the main beneficiaries...
  79. ncbi request reprint Randomized controlled trial of interventions designed to reduce the risk of progression to first-episode psychosis in a clinical sample with subthreshold symptoms
    Patrick D McGorry
    Early Psychosis Prevention and Intervention Centre, Melbourne, Australia
    Arch Gen Psychiatry 59:921-8. 2002
    ..However, only recently has it been possible to engage people in treatment during this phase...
  80. ncbi request reprint Hippocampal and anterior cingulate morphology in subjects at ultra-high-risk for psychosis: the role of family history of psychotic illness
    Stephen J Wood
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne, National Neuroscience Facility, 161 Barry Street, Carlton South VIC 3053, Australia
    Schizophr Res 75:295-301. 2005
    ..Some appear to predate the illness and may be genetic in origin, while others are associated with the onset of the disorder...
  81. doi request reprint Motives for substance use among young people seeking mental health treatment
    Leanne Hides
    ORYGEN Research Centre, Department of Psychiatry, University of Melbourne, Melbourne, Victoria, Australia
    Early Interv Psychiatry 2:188-94. 2008
    ..To explore substance use motives among young people seeking mental health treatment...
  82. doi request reprint Cost implications of specific and non-specific treatment for young persons at ultra high risk of developing a first episode of psychosis
    Lisa J Phillips
    Departments of Psychology and Psychiatry, University of Melbourne, Orygen Health Research Centre, Parkville, VIC 3010, Australia
    Early Interv Psychiatry 3:28-34. 2009
    ..This paper reports cost implications of providing psychological and pharmacological intervention for individuals at UHR for psychosis compared with minimal psychological treatment...
  83. doi request reprint Does disturbance of self underlie social cognition deficits in schizophrenia and other psychotic disorders?
    Barnaby Nelson
    ORYGEN Research Centre, University of Melbourne, Parkville, Victoria, Australia
    Early Interv Psychiatry 3:83-93. 2009
    ..This paper attempts to integrate a strand of cognitive research in psychotic disorders (specifically, social cognition research) with phenomenological accounts of schizophrenia and other psychotic disorders...
  84. ncbi request reprint Can we detect psychotic-like experiences in the general population?
    B Nelson
    Orygen Youth Health Research Centre, Centre for Youth Mental Health, University of Melbourne, Australia
    Curr Pharm Des 18:376-85. 2012
    ....
  85. ncbi request reprint Early-onset of symptoms predicts conversion to non-affective psychosis in ultra-high risk individuals
    G P Amminger
    ORYGEN Research Centre incorporating the PACE Clinic, Department of Psychiatry, University of Melbourne, Australia
    Schizophr Res 84:67-76. 2006
    ..We examined if age of onset of psychiatric symptoms and/or sex predict conversion to non-affective or affective psychosis in individuals considered to be at ultra-high risk for schizophrenia...
  86. doi request reprint Psychotic symptoms with sexual content in the "ultra high risk" for psychosis population: frequency and association with sexual trauma
    Andrew Thompson
    The PACE Clinic, ORYGEN Youth Health, Parkville, Melbourne, Australia
    Psychiatry Res 177:84-91. 2010
    ..17, P<0.01). This relationship remained significant when other traumatic experiences, PTSD diagnosis, age and sex were adjusted for. Further research into this relationship with regard to outcome and treatment is warranted...
  87. ncbi request reprint Sustained attention in young people at high risk of psychosis does not predict transition to psychosis
    Shona M Francey
    PACE Clinic, ORYGEN Youth Health, Locked Bag 10, Parkville, 3052, Australia
    Schizophr Res 79:127-36. 2005
    ..These results support sustained attention as an indicator of vulnerability to psychosis, but suggest that CPT-IP performance does not help to predict transition to psychosis in an ultra high-risk group...
  88. ncbi request reprint Antibodies to infectious agents in individuals at ultra-high risk for psychosis
    G Paul Amminger
    ORYGEN Research Centre, Department of Psychiatry, University of Melbourne, Australia
    Biol Psychiatry 61:1215-7. 2007
    ..While there is evidence that some cases of schizophrenia may be associated with microbial infections, the role of microbial agents has not been investigated in people with emerging psychosis...
  89. ncbi request reprint Prepsychotic phase of schizophrenia and related disorders: recent progress and future opportunities
    Lisa J Phillips
    PACE Clinic, ORYGEN Research Centre, Locked Bag 10, Parkville 8052, Victoria, Australia
    Br J Psychiatry Suppl 48:s33-44. 2005
    ..Clinical and research focus has recently shifted from established psychotic disorders to first-episode psychosis and the prepsychotic phase of illness...
  90. pmc The phenomenological critique and self-disturbance: implications for ultra-high risk ("prodrome") research
    Barnaby Nelson
    ORYGEN Research Centre, 35 Poplar Road Locked Bag 10, Parkville, Victoria 3052, Australia
    Schizophr Bull 34:381-92. 2008
    ..The strong explanatory power and empirical findings to date invite further research into the role of self-disturbance as a phenotypic vulnerability marker for psychotic disorder...
  91. ncbi request reprint Pituitary volume in psychosis
    Carmine M Pariante
    Division of Psychological Medicine, Institute of Psychiatry, King s College London, UK
    Br J Psychiatry 185:5-10. 2004
    ..Patients with psychosis have activation of the hypothalamic-pituitary-adrenal (HPA) axis during the acute phase of the psychosis. Whether this has any morphological consequences for the pituitary gland is currently unknown...
  92. ncbi request reprint Obstetric complications and transition to psychosis in an "ultra" high risk sample
    Yang Yun
    Mental Health Center, West China Hospital, Sichuan University, 7 Xiaoxue Road, Chengdu, Sichuan Province 610044, China
    Aust N Z J Psychiatry 39:460-6. 2005
    ..In this study, the association between OCs and the development of psychotic disorder was studied in a group of 74 young people identified as being at very high risk for the first onset of psychosis...
  93. ncbi request reprint Early psychosis: where we've been, where we still have to go
    Eoin Killackey
    Epidemiol Psichiatr Soc 16:102-8. 2007
    ..In order to continue to develop, while enjoying the benefits of being a mainstream intervention, early intervention must not stray too far from its reformist roots...
  94. ncbi request reprint The transition to psychosis: risk factors and brain changes
    Stephen J Wood
    Epidemiol Psichiatr Soc 13:137-40. 2004
  95. doi request reprint Prediction of psychosis: setting the stage
    Alison R Yung
    Br J Psychiatry Suppl 51:s1-8. 2007
    ..More research is required in prediction, neurobiology and treatment...