Heather M Young

Summary

Affiliation: University of Melbourne
Country: Australia

Publications

  1. Young H, Bergner A, Simpson M, McKeown S, Hao M, Anderson C, et al. Colonizing while migrating: how do individual enteric neural crest cells behave?. BMC Biol. 2014;12:23 pubmed publisher
    ..Each gut region is initially populated by sub-populations of ENCCs migrating non-directionally, rather than stopping. This might provide a mechanism for ensuring a uniform density of ENCCs along the growing gut. ..
  2. Young H, Stamp L, McKeown S. ENS Development Research Since 1983: Great Strides but Many Remaining Challenges. Adv Exp Med Biol. 2016;891:53-62 pubmed publisher
    ..In this article, we review what was known about the development of the ENS in 1983 and then summarize some of the major advances in the field since 1983. ..
  3. Parish I, Stamp L, Lorenzo A, Fowler S, Sontani Y, Miosge L, et al. A Novel Mutation in Nucleoporin 35 Causes Murine Degenerative Colonic Smooth Muscle Myopathy. Am J Pathol. 2016;186:2254-61 pubmed publisher
    ..Nup35 mice are likely to be a valuable model for the subtype of CIPO characterized by degenerative myopathy. Our study also raises the possibility that Nup35 polymorphisms could contribute to some cases of CIPO. ..
  4. Stamp L, Gwynne R, Foong J, Lomax A, Hao M, Kaplan D, et al. Optogenetic Demonstration of Functional Innervation of Mouse Colon by Neurons Derived From Transplanted Neural Cells. Gastroenterology. 2017;152:1407-1418 pubmed publisher
    ..Circuits composed of both motor neurons and interneurons were established, but the age at which cells are isolated influences the neurotransmitter phenotype of interneurons that are generated. ..
  5. Stewart A, Anderson R, Kobayashi K, Young H. Effects of NGF, NT-3 and GDNF family members on neurite outgrowth and migration from pelvic ganglia from embryonic and newborn mice. BMC Dev Biol. 2008;8:73 pubmed publisher
    ..5 and to neurturin only in E14.5 mice. Our data show that there are both age-dependent and neuron type-dependent differences in the responsiveness of embryonic and neo-natal pelvic ganglion neurons to growth factors. ..
  6. Young H, Bergner A, Muller T. Acquisition of neuronal and glial markers by neural crest-derived cells in the mouse intestine. J Comp Neurol. 2003;456:1-11 pubmed
    ..5(+) nor S100b(+). Because some classes of neurons are not present in significant numbers until after birth, the expression of PGP9.5 by developing enteric neurons appeared to precede the expression of neuron type-specific markers. ..
  7. Young H, Turner K, Bergner A. The location and phenotype of proliferating neural-crest-derived cells in the developing mouse gut. Cell Tissue Res. 2005;320:1-9 pubmed
    ..5). Thus, for enteric neurons, exit from the cell cycle appears to occur after the expression of pan-neuronal proteins but prior to the expression of markers of terminally differentiated neurons. ..
  8. Hirst C, Stamp L, Bergner A, Hao M, Tran M, Morgan J, et al. Kif1bp loss in mice leads to defects in the peripheral and central nervous system and perinatal death. Sci Rep. 2017;7:16676 pubmed publisher
    ..Our mouse model provides a valuable resource to understand GOSHS. ..