N D Yeomans
Affiliation: University of Western Sydney
- Maintenance treatment with esomeprazole following initial relief of non-steroidal anti-inflammatory drug-associated upper gastrointestinal symptoms: the NASA2 and SPACE2 studiesChristopher J Hawkey
Institute of Clinical Research, Trials Unit, Wolfson Digestive Diseases Centre, University Hospital, Derby Road, Nottingham, NG7 2UH, UK
Arthritis Res Ther 9:R17. 2007..The frequency of adverse events was similar in the three groups. Esomeprazole maintains relief of NSAID-associated upper GI symptoms in patients taking continuous NSAIDs, including selective COX-2 inhibitors...
- Is ranitidine therapy sufficient for healing peptic ulcers associated with non-steroidal anti-inflammatory drug use?N D Yeomans
School of Medicine, University of Western Sydney, NSW, Australia
Int J Clin Pract 60:1401-7. 2006..81% for ranitidine, p < 0.05) and 88% for omeprazole 40 mg (p = 0.17 vs. ranitidine). NSAID-associated GU are more likely to heal when patients receive concomitant treatment with a PPI rather than ranitidine...
- Prevalence and incidence of gastroduodenal ulcers during treatment with vascular protective doses of aspirinN D Yeomans
Western Hospital, Department of Medicine, University of Melbourne, Melbourne, and University of Western Sydney, Sydney, Australia
Aliment Pharmacol Ther 22:795-801. 2005..Aspirin is valuable for preventing vascular events, but information about ulcer frequency is necessary to inform risk-benefit decisions in individual patients...
- Systematic review: ulcer definition in NSAID ulcer prevention trialsN D Yeomans
School of Medicine, University of Western Sydney, Sydney, NSW, Australia
Aliment Pharmacol Ther 27:465-72. 2008..In clinical trials of peptic ulcer prevention, the most appropriate definition of an ulcer remains challenging...
- Reducing the risk of gastroduodenal ulcers with a fixed combination of esomeprazole and low-dose acetyl salicylic acidNeville D Yeomans
School of Medicine, University of Western Sydney, Locked Bag 1797, Penrith South, NSW 2751, Australia
Expert Rev Gastroenterol Hepatol 5:447-55. 2011..This article reviews the pharmacology of the component agents and the evidence for efficacy of the combination of esomeprazole and low-dose ASA...
- Gastroduodenal toxicity of low-dose acetylsalicylic acid: a comparison with non-steroidal anti-inflammatory drugsNeville D Yeomans
School of Medicine, University of Western Sydney, Penrith South DC, NSW 1797, Australia
Curr Med Res Opin 25:2785-93. 2009..This was a narrative, descriptive review, rather than a formal systematic review...
- Overview of 50 years' progress in upper gastrointestinal diseasesNeville D Yeomans
School of Medicine, University of Western Sydney, Penrith South DC, New South Wales, Australia
J Gastroenterol Hepatol 24:S2-4. 2009..The story of the development of the histamine H(2)-receptor antagonists and the proton pump inhibitors is also outlined...
- Aspirin: old drug, new uses and challengesNeville D Yeomans
School of Medicine, University of Western Sydney, Sydney, New South Wales, Australia
J Gastroenterol Hepatol 26:426-31. 2011..Strategies that can be used to reduce these risks include using the lowest effective aspirin dose and co-prescribing acid suppressants...
- The ulcer sleuths: The search for the cause of peptic ulcersNeville D Yeomans
University of Western Sydney, Sydney, Australia
J Gastroenterol Hepatol 26:35-41. 2011..Understanding the mechanism of the first, and the discovery and demonstration of Koch's postulates for the second, have been instrumental in the award of two Nobel prizes...
- Predictors of gastroduodenal erosions in patients taking low-dose aspirinJ Hart
Royal North Shore Hospital, St Leonards, Sydney, NSW, Australia
Aliment Pharmacol Ther 31:143-9. 2010..Gastroduodenal ulcers are common in patients taking low-dose aspirin. However, the factors predisposing to mucosal erosions, the precursor lesions, are not well known...
- Trefoil peptides are early markers of gastrointestinal maturation in the ratM Familari
The University of Melbourne, Department of Medicine, Western Hospital, Footscray, Australia
Int J Dev Biol 42:783-9. 1998..The time course of their expression, well before the mucus cell type is specified, suggests a potential role in epithelial cell differentiation...
- The nonsteroidal anti-inflammatory drugs controversyN D Yeomans
Department of Medicine, University of Melbourne, Western Hospital, Melbourne, Australia
Gastroenterol Clin North Am 29:791-805. 2000..Possibilities include greater efficacy of antisecretory agents, a smaller inhibition of prostaglandin production, and a blunted apoptotic response in patients who are infected with H. pylori and take NSAIDs...
- Randomized trial of omeprazole and metronidazole with amoxycillin or clarithromycin for Helicobacter pylori eradication, in a region of high primary metronidazole resistance: the HERO studyP H Katelaris
Gastroenterology Unit, Concord Hospital, Sydney, Australia
Aliment Pharmacol Ther 14:751-8. 2000..The efficacy of omeprazole-based eradication therapies has been determined mostly in populations with low to moderate prevalence of metronidazole resistant Helicobacter pylori, yet resistance is high in many regions...
- Augmented gp130-mediated cytokine signalling accompanies human gastric cancer progressionC B Jackson
Gastrointestinal Cancer Lab, Department of Medicine, The University of Melbourne at Western Hospital, Footscray, 3011, Melbourne, Australia
J Pathol 213:140-51. 2007..IL-11 expression is associated with adenocarcinoma development, but not gastritic lesions, and we identify a novel mechanism for IL-11 as a potent inducer of proliferation in the human gastric cancer setting...
- Spatio-temporal expression of trefoil peptide following severe gastric ulceration in the rat implicates it in late-stage repair processesM Ulaganathan
Department of Medicine, University of Melbourne at Western Hospital, Footscray, Victoria, Australia
J Gastroenterol Hepatol 16:506-12. 2001..The role of TFF1 in gastric mucosal repair was examined by analysis of the spatio-temporal expression of TFF1 following gastric ulceration in the rat...
- Impact of cyclooxygenase-2 inhibitors: are they fulfilling their promises?N D Yeomans
Intern Med J 34:145-7. 2004
- Influence of sex and Helicobacter pylori on development and healing of gastroduodenal lesions in non-steroidal anti-inflammatory drug usersC J Hawkey
Division of Gastroenterology, University Hospital Nottingham, Queen s Medical Centre, Nottingham, UK
Gut 51:344-50. 2002..Factors predisposing to endoscopic ulcer formation or healing with non-steroidal anti-inflammatory drugs (NSAIDs) have not been well defined...
- Relative contribution of mucosal injury and Helicobacter pylori in the development of gastroduodenal lesions in patients taking non-steroidal anti-inflammatory drugsC J Hawkey
Division of Gastroenterology, University Hospital, Queen s Medical Centre, Nottingham, UK
Gut 51:336-43. 2002..Whether this is due to Helicobacter pylori infection or to reactivation of the original lesion is unclear...
- Efficacy of esomeprazole for resolution of symptoms of heartburn and acid regurgitation in continuous users of non-steroidal anti-inflammatory drugsC J Hawkey
Institute of Clinical Research Trials Unit, University Hospital, Nottingham, UK
Aliment Pharmacol Ther 25:813-21. 2007..The use of non-steroidal anti-inflammatory drugs (NSAIDs) is often associated with upper gastrointestinal symptoms such as heartburn and acid regurgitation...