Bu Beng Yeap

Summary

Affiliation: University of Western Australia
Country: Australia

Publications

  1. ncbi request reprint In men older than 70 years, total testosterone remains stable while free testosterone declines with age. The Health in Men Study
    Bu B Yeap
    School of Medicine and Pharmacology, University of Western Australia, Crawley, Western Australia, Australia
    Eur J Endocrinol 156:585-94. 2007
  2. ncbi request reprint Higher serum free testosterone is associated with better cognitive function in older men, while total testosterone is not. The Health In Men Study
    Bu B Yeap
    School of Medicine and Pharmacology, University of Western Australia, Australia
    Clin Endocrinol (Oxf) 68:404-12. 2008
  3. doi request reprint Testosterone and ill-health in aging men
    Bu B Yeap
    School of Medicine and Pharmacology, University of Western Australia, WA, Australia
    Nat Clin Pract Endocrinol Metab 5:113-21. 2009
  4. doi request reprint Androgens and cardiovascular disease
    Bu B Yeap
    School of Medicine and Pharmacology, University of Western Australia, Perth, Australia
    Curr Opin Endocrinol Diabetes Obes 17:269-76. 2010
  5. doi request reprint Reduced serum total osteocalcin is associated with metabolic syndrome in older men via waist circumference, hyperglycemia, and triglyceride levels
    Bu B Yeap
    School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia 6009, Australia
    Eur J Endocrinol 163:265-72. 2010
  6. doi request reprint Hormones and health outcomes in aging men
    Bu B Yeap
    School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia
    Exp Gerontol 48:677-81. 2013
  7. doi request reprint Do low testosterone levels contribute to ill-health during male ageing?
    Bu B Yeap
    School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia
    Crit Rev Clin Lab Sci 49:168-82. 2012
  8. doi request reprint Higher free thyroxine levels predict increased incidence of dementia in older men: the Health in Men Study
    Bu B Yeap
    School of Medicine and Pharmacology, Centre for Medical Research, University of Western Australia, Crawley, Western Australia 6009, Australia
    J Clin Endocrinol Metab 97:E2230-7. 2012
  9. doi request reprint Reference ranges and determinants of testosterone, dihydrotestosterone, and estradiol levels measured using liquid chromatography-tandem mass spectrometry in a population-based cohort of older men
    Bu B Yeap
    School of Medicine and Pharmacology, Level 2, T Block, Fremantle Hospital, Alma Street, Fremantle, Western Australia 6160, Australia
    J Clin Endocrinol Metab 97:4030-9. 2012
  10. doi request reprint Higher free thyroxine levels are associated with frailty in older men: the Health In Men Study
    Bu B Yeap
    School of Medicine and Pharmacology, University of Western Australia, Western Australia, Australia
    Clin Endocrinol (Oxf) 76:741-8. 2012

Collaborators

Detail Information

Publications33

  1. ncbi request reprint In men older than 70 years, total testosterone remains stable while free testosterone declines with age. The Health in Men Study
    Bu B Yeap
    School of Medicine and Pharmacology, University of Western Australia, Crawley, Western Australia, Australia
    Eur J Endocrinol 156:585-94. 2007
    ..We sought to determine the distribution and associations of reduced testosterone concentrations in older men...
  2. ncbi request reprint Higher serum free testosterone is associated with better cognitive function in older men, while total testosterone is not. The Health In Men Study
    Bu B Yeap
    School of Medicine and Pharmacology, University of Western Australia, Australia
    Clin Endocrinol (Oxf) 68:404-12. 2008
    ..To determine the relationship of total and free serum testosterone to cognitive performance in older men...
  3. doi request reprint Testosterone and ill-health in aging men
    Bu B Yeap
    School of Medicine and Pharmacology, University of Western Australia, WA, Australia
    Nat Clin Pract Endocrinol Metab 5:113-21. 2009
    ..Further studies are also needed to establish whether the age-related decline in circulating testosterone level in men can be modified or prevented...
  4. doi request reprint Androgens and cardiovascular disease
    Bu B Yeap
    School of Medicine and Pharmacology, University of Western Australia, Perth, Australia
    Curr Opin Endocrinol Diabetes Obes 17:269-76. 2010
    ..Relationships between androgens and cardiovascular disease will be discussed, with particular attention to more recently published research...
  5. doi request reprint Reduced serum total osteocalcin is associated with metabolic syndrome in older men via waist circumference, hyperglycemia, and triglyceride levels
    Bu B Yeap
    School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia 6009, Australia
    Eur J Endocrinol 163:265-72. 2010
    ..However, the relationship between TOC levels and other cardiovascular risk factors is uncertain. We sought to determine whether serum TOC is associated with metabolic syndrome and its components in older men...
  6. doi request reprint Hormones and health outcomes in aging men
    Bu B Yeap
    School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia
    Exp Gerontol 48:677-81. 2013
    ..Clarification of the roles of endogenous testosterone and thyroxine in the genesis of ill-health during male aging offers the prospect of future intervention to preserve health and well-being in this growing population...
  7. doi request reprint Do low testosterone levels contribute to ill-health during male ageing?
    Bu B Yeap
    School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia
    Crit Rev Clin Lab Sci 49:168-82. 2012
    ....
  8. doi request reprint Higher free thyroxine levels predict increased incidence of dementia in older men: the Health in Men Study
    Bu B Yeap
    School of Medicine and Pharmacology, Centre for Medical Research, University of Western Australia, Crawley, Western Australia 6009, Australia
    J Clin Endocrinol Metab 97:E2230-7. 2012
    ..Both hypothyroidism and subclinical hyperthyroidism hinder cognitive function...
  9. doi request reprint Reference ranges and determinants of testosterone, dihydrotestosterone, and estradiol levels measured using liquid chromatography-tandem mass spectrometry in a population-based cohort of older men
    Bu B Yeap
    School of Medicine and Pharmacology, Level 2, T Block, Fremantle Hospital, Alma Street, Fremantle, Western Australia 6160, Australia
    J Clin Endocrinol Metab 97:4030-9. 2012
    ..Objective: We assessed the associations of T, DHT, and E2 in men aged 70 yr or older and established reference ranges for these in healthy older men...
  10. doi request reprint Higher free thyroxine levels are associated with frailty in older men: the Health In Men Study
    Bu B Yeap
    School of Medicine and Pharmacology, University of Western Australia, Western Australia, Australia
    Clin Endocrinol (Oxf) 76:741-8. 2012
    ..Some symptoms of frailty overlap those of thyroid dysfunction, but it is unclear whether differences in thyroid status influence risk of frailty. We evaluated associations between thyroid status and frailty in older men...
  11. doi request reprint Associations of IGF1 and its binding proteins with abdominal aortic aneurysm and aortic diameter in older men
    Bu B Yeap
    School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia, Australia
    Eur J Endocrinol 166:191-7. 2012
    ..However, the relationship of the IGF1 system with aortic dilation and AAA is unclear. We tested the hypothesis that circulating IGF1 and IGFBPs are associated with AAA and aortic diameter in older men...
  12. doi request reprint IGF1 and its binding proteins 3 and 1 are differentially associated with metabolic syndrome in older men
    Bu B Yeap
    School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia 6009, Australia
    Eur J Endocrinol 162:249-57. 2010
    ..The relationship between IGF-binding proteins 3 and 1 (IGFBP3 and IGFBP1) with risk of cardiovascular disease remains unclear. We sought to examine associations between IGF1, IGFBP3 and IGFBP1 with metabolic syndrome in older men...
  13. doi request reprint Associations of total testosterone, sex hormone-binding globulin, calculated free testosterone, and luteinizing hormone with prevalence of abdominal aortic aneurysm in older men
    Bu B Yeap
    School of Medicine and Pharmacology, Level 2, T Block, Fremantle Hospital, Alma Street, P O Box 480, Fremantle, Western Australia 6959, Australia
    J Clin Endocrinol Metab 95:1123-30. 2010
    ..Additional studies are needed to clarify direction of causality and determine possible scope for preventive intervention...
  14. doi request reprint The C282Y polymorphism of the hereditary hemochromatosis gene is associated with increased sex hormone-binding globulin and normal testosterone levels in men
    B B Yeap
    School of Medicine and Pharmacology, University of Western Australia, Perth, Australia
    J Endocrinol Invest 33:544-8. 2010
    ..However, it is unclear whether men who are heterozygotes for C282Y or H63D exhibit subtle abnormalities of sex hormone status...
  15. doi request reprint Associations of total osteocalcin with all-cause and cardiovascular mortality in older men. The Health In Men Study
    B B Yeap
    School of Medicine and Pharmacology, University of Western Australia, Perth, WA, Australia
    Osteoporos Int 23:599-606. 2012
    ..Differences in osteocalcin levels might influence glucose metabolism and thereby cardiovascular risk, or reflect changes in bone turnover thus representing a marker for poorer health outcomes...
  16. doi request reprint Associations of IGF1 and IGFBPs 1 and 3 with all-cause and cardiovascular mortality in older men: the Health In Men Study
    Bu B Yeap
    School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia, Australia
    Eur J Endocrinol 164:715-23. 2011
    ..We examined associations of IGF1, IGFBP1 and IGFBP3 with all-cause and cardiovascular mortality in older men...
  17. ncbi request reprint Testosterone and sex in older men
    Bu B Yeap
    School of Medicine and Pharmacology, University of Western Australia, Perth, WA, Australia
    Med J Aust 195:61-2. 2011
    ..New data from the Health in Men Study raise questions about the role of testosterone supplementation in ageing men...
  18. doi request reprint Lower serum testosterone is independently associated with insulin resistance in non-diabetic older men: the Health In Men Study
    Bu B Yeap
    School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia 6009, Australia
    Eur J Endocrinol 161:591-8. 2009
    ..We examined whether lower testosterone or sex hormone-binding globulin (SHBG) levels in older men are associated with insulin resistance independently of measures of central obesity...
  19. doi request reprint Lower testosterone levels predict incident stroke and transient ischemic attack in older men
    Bu B Yeap
    School of Medicine and Pharmacology, University of Western Australia, Crawley, WA 6009, Australia
    J Clin Endocrinol Metab 94:2353-9. 2009
    ..However, it is unclear whether lower testosterone levels predict major cardiovascular events...
  20. ncbi request reprint Primary care diabetes. What options are there?
    B B Yeap
    University of Western Australia, Department of Endocrinology and Diabetes, Fermantle Hospital, Western Australia
    Aust Fam Physician 30:1122-8. 2001
    ..Weight reduction and oral hypoglycaemic therapy has been accompanied by new drug treatment options in type 2 diabetes, while refinements in insulin delivery are more relevant for patients with type 1 diabetes...
  21. ncbi request reprint Type 2 diabetes mellitus--guidelines for initiating insulin therapy
    Bu Beng Yeap
    Department of Endocrinology and Diabetes, Fremantle Hospital, Western Australia, Australia
    Aust Fam Physician 36:549-53. 2007
    ..Insulin is often indicated for patients with suboptimally controlled type 2 diabetes mellitus, despite lifestyle modification and oral antidiabetic agents...
  22. doi request reprint Healthier lifestyle predicts higher circulating testosterone in older men: the Health In Men Study
    Bu B Yeap
    School of Medicine and Pharmacology, University of Western Australia, Fremantle Hospital, Fremantle, Australia
    Clin Endocrinol (Oxf) 70:455-63. 2009
    ..We sought to determine whether greater participation in healthy behaviours predicted reduced risk of subsequent lower circulating testosterone in older men...
  23. doi request reprint Are declining testosterone levels a major risk factor for ill-health in aging men?
    B B Yeap
    School of Medicine and Pharmacology, University of Western Australia, Department of Endocrinology and Diabetes, Fremantle Hospital, WA, Australia
    Int J Impot Res 21:24-36. 2009
    ..Additional consideration should be given to designing and testing interventions that may prevent or ameliorate the age-related decline in testosterone levels in men...
  24. ncbi request reprint Controversies in type 2 diabetes - An update
    Bu B Yeap
    School of Medicine and Pharmacology, University of Western Australia, and Head, Department of Endocrinology and Diabetes, Fremantle Hospital, Western Australia
    Aust Fam Physician 38:22-5. 2009
    ..Results from the Action to Control Cardiovascular Risk in Diabetes (ACCORD) study have stimulated debate about appropriate glycated haemoglobin (HbA1c) targets...
  25. doi request reprint Low free testosterone predicts frailty in older men: the health in men study
    Zoe Hyde
    Western Australian Centre for Health and Ageing M570, University of Western Australia, 35 Stirling Highway, Crawley, Western Australia 6009, Australia
    J Clin Endocrinol Metab 95:3165-72. 2010
    ..The prevalence of frailty increases, whereas testosterone decreases, as men age. Low testosterone may be a risk factor for development of this syndrome...
  26. doi request reprint Low free testosterone concentration as a potentially treatable cause of depressive symptoms in older men
    Osvaldo P Almeida
    WA Centre for Health and Ageing, University of Western Australia, Perth, Australia
    Arch Gen Psychiatry 65:283-9. 2008
    ..Serum concentrations of gonadal hormones have been associated with various measures of well-being, but it is unclear whether their association with mood is confounded by concurrent physical morbidity...
  27. doi request reprint Higher luteinizing hormone is associated with poor memory recall: the health in men study
    Zoe Hyde
    Western Australian Institute for Medical Research, Australia
    J Alzheimers Dis 19:943-51. 2010
    ..These findings suggest a role for both androgens and gonadotropins in differing cognitive domains, and that gonadotropins may influence cognition independent of sex steroids...
  28. ncbi request reprint Inhibition of adult liver progenitor (oval) cell growth and viability by an agonist of the peroxisome proliferator activated receptor (PPAR) family member gamma, but not alpha or delta
    Belinda Knight
    School of Medicine and Pharmacology, University of Western Australia, Nedlands, WA, Australia
    Carcinogenesis 26:1782-92. 2005
    ..In summary, PPARgamma agonists reduce oval cell proliferation and fibrosis during chronic liver injury and may be useful in the prevention of hepatocellular carcinoma...
  29. doi request reprint Lower sex hormone-binding globulin is more strongly associated with metabolic syndrome than lower total testosterone in older men: the Health in Men Study
    S A Paul Chubb
    PathWest, Department of Biochemistry, Fremantle Hospital, Western Australia, 6160 Australia
    Eur J Endocrinol 158:785-92. 2008
    ..As SHBG increases with age while testosterone declines, we examined the relative contributions of SHBG and testosterone to the risk of metabolic syndrome in older men...
  30. ncbi request reprint Differential modulation of cell cycle, apoptosis and PPARgamma2 gene expression by PPARgamma agonists ciglitazone and 9-hydroxyoctadecadienoic acid in monocytic cells
    Jade K A Hampel
    School of Medicine and Pharmacology, University of Western Australia, Fremantle and Royal Perth Hospitals, Australia
    Prostaglandins Leukot Essent Fatty Acids 74:283-93. 2006
    ....
  31. ncbi request reprint The androgen receptor mRNA
    Bu B Yeap
    School of Medicine and Pharmacology, The University of Western Australia, Fremantle and Royal Perth Hospitals, Perth, Western Australia, Australia
    Bioessays 26:672-82. 2004
    ....
  32. ncbi request reprint Monocyte-derived macrophages from men and women with Type 2 diabetes mellitus differ in fatty acid composition compared with non-diabetic controls
    Saranga Senanayake
    School of Medicine and Pharmacology, University of Western Australia, Fremantle and Royal Perth Hospitals, Western Australia, Australia
    Diabetes Res Clin Pract 75:292-300. 2007
    ..This pattern of altered macrophage fatty acid composition may be relevant to diabetic atherogenesis...
  33. ncbi request reprint Novel binding of HuR and poly(C)-binding protein to a conserved UC-rich motif within the 3'-untranslated region of the androgen receptor messenger RNA
    Bu B Yeap
    Laboratory for Cancer Medicine, Western Australian Institute for Medical Research, University Department of Medicine, University of Western Australia, 50 Murray Street, Perth, WA 6000, Australia
    J Biol Chem 277:27183-92. 2002
    ..The binding of HuR, CP1, and CP2 to AR mRNA suggests a role for each of these proteins in the post-transcriptional regulation of AR expression in cancer cells...