Alpha S Yap

Summary

Affiliation: University of Queensland
Country: Australia

Publications

  1. pmc Making and breaking contacts: the cellular biology of cadherin regulation
    Alpha S Yap
    Division of Molecular Cell Biology, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane, Queensland 4072, Australia
    Curr Opin Cell Biol 19:508-14. 2007
  2. pmc Cortactin is a functional target of E-cadherin-activated Src family kinases in MCF7 epithelial monolayers
    Gang Ren
    Division of Molecular Cell Biology, Institute for Molecular Bioscience, University of Queensland, St Lucia, Brisbane 4072, Australia
    J Biol Chem 284:18913-22. 2009
  3. ncbi request reprint Dynamic microtubules regulate the local concentration of E-cadherin at cell-cell contacts
    Samantha J Stehbens
    Division of Molecular Cell Biology, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane, Queensland 4072, Australia
    J Cell Sci 119:1801-11. 2006
  4. pmc Ena/VASP proteins can regulate distinct modes of actin organization at cadherin-adhesive contacts
    Jeanie A Scott
    Division of Molecular Cell Biology, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane, Queensland, Australia 4072
    Mol Biol Cell 17:1085-95. 2006
  5. pmc E-cadherin adhesion activates c-Src signaling at cell-cell contacts
    Robert W McLachlan
    Division of Molecular Cell Biology, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane, Queensland, Australia 4072
    Mol Biol Cell 18:3214-23. 2007
  6. doi request reprint Centralspindlin and α-catenin regulate Rho signalling at the epithelial zonula adherens
    Aparna Ratheesh
    Division of Molecular Cell Biology, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane 4072, Queensland, Australia
    Nat Cell Biol 14:818-28. 2012
  7. pmc A WAVE2-Arp2/3 actin nucleator apparatus supports junctional tension at the epithelial zonula adherens
    Suzie Verma
    Division of Molecular Cell Biology, Institute for Molecular Bioscience, St Lucia, Brisbane 4072, Australia
    Mol Biol Cell 23:4601-10. 2012
  8. doi request reprint Phosphatidylinositol 3'-kinase signalling supports cell height in established epithelial monolayers
    Angela Jeanes
    Division of Molecular Cell Biology, Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD 4072, Australia
    J Mol Histol 40:395-405. 2009
  9. ncbi request reprint Arp2/3 activity is necessary for efficient formation of E-cadherin adhesive contacts
    Suzie Verma
    Institute for Molecular Bioscience, School for Biomedical Science, The University of Queensland, St Lucia, Queensland 4072, Australia
    J Biol Chem 279:34062-70. 2004
  10. pmc Cortactin is necessary for E-cadherin-mediated contact formation and actin reorganization
    Falak M Helwani
    Institute for Molecular Bioscience, University of Queensland, St Lucia, Brisbane, Queensland 4072, Australia
    J Cell Biol 164:899-910. 2004

Collaborators

Detail Information

Publications51

  1. pmc Making and breaking contacts: the cellular biology of cadherin regulation
    Alpha S Yap
    Division of Molecular Cell Biology, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane, Queensland 4072, Australia
    Curr Opin Cell Biol 19:508-14. 2007
    ..Similarly, at the surface, components of tight junctions provide a mode of cross-talk that regulates assembly of adherens junctions...
  2. pmc Cortactin is a functional target of E-cadherin-activated Src family kinases in MCF7 epithelial monolayers
    Gang Ren
    Division of Molecular Cell Biology, Institute for Molecular Bioscience, University of Queensland, St Lucia, Brisbane 4072, Australia
    J Biol Chem 284:18913-22. 2009
    ..We conclude that SFK and cortactin constitute an important signaling pathway that functionally links E-cadherin adhesion and the actin cytoskeleton...
  3. ncbi request reprint Dynamic microtubules regulate the local concentration of E-cadherin at cell-cell contacts
    Samantha J Stehbens
    Division of Molecular Cell Biology, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane, Queensland 4072, Australia
    J Cell Sci 119:1801-11. 2006
    ....
  4. pmc Ena/VASP proteins can regulate distinct modes of actin organization at cadherin-adhesive contacts
    Jeanie A Scott
    Division of Molecular Cell Biology, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane, Queensland, Australia 4072
    Mol Biol Cell 17:1085-95. 2006
    ..We propose that Ena/VASP proteins may serve as higher order regulators of the cytoskeleton at cadherin contacts through their ability to modulate distinct modes of actin organization at those contacts...
  5. pmc E-cadherin adhesion activates c-Src signaling at cell-cell contacts
    Robert W McLachlan
    Division of Molecular Cell Biology, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane, Queensland, Australia 4072
    Mol Biol Cell 18:3214-23. 2007
    ....
  6. doi request reprint Centralspindlin and α-catenin regulate Rho signalling at the epithelial zonula adherens
    Aparna Ratheesh
    Division of Molecular Cell Biology, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane 4072, Queensland, Australia
    Nat Cell Biol 14:818-28. 2012
    ..Thus, a conserved molecular ensemble that governs Rho activation during cytokinesis is used in interphase cells to control the Rho GTPase cycle at the zonula adherens...
  7. pmc A WAVE2-Arp2/3 actin nucleator apparatus supports junctional tension at the epithelial zonula adherens
    Suzie Verma
    Division of Molecular Cell Biology, Institute for Molecular Bioscience, St Lucia, Brisbane 4072, Australia
    Mol Biol Cell 23:4601-10. 2012
    ..WAVE2-Arp2/3 disruption depleted junctions of both myosin IIA and IIB, suggesting that dynamic actin assembly may support junctional tension by facilitating the local recruitment of myosin...
  8. doi request reprint Phosphatidylinositol 3'-kinase signalling supports cell height in established epithelial monolayers
    Angela Jeanes
    Division of Molecular Cell Biology, Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD 4072, Australia
    J Mol Histol 40:395-405. 2009
    ..This is independent of potential effects on adhesion or polarity, but may occur through PI3-kinase-stimulated Rac signaling...
  9. ncbi request reprint Arp2/3 activity is necessary for efficient formation of E-cadherin adhesive contacts
    Suzie Verma
    Institute for Molecular Bioscience, School for Biomedical Science, The University of Queensland, St Lucia, Queensland 4072, Australia
    J Biol Chem 279:34062-70. 2004
    ..These findings demonstrate that Arp2/3 activity is necessary for cells to efficiently extend and assemble cadherin-based adhesive contacts...
  10. pmc Cortactin is necessary for E-cadherin-mediated contact formation and actin reorganization
    Falak M Helwani
    Institute for Molecular Bioscience, University of Queensland, St Lucia, Brisbane, Queensland 4072, Australia
    J Cell Biol 164:899-910. 2004
    ..Together, our findings identify a necessary role for cortactin in the cadherin-actin cooperation that supports productive contact formation...
  11. ncbi request reprint Contextual binding of p120ctn to E-cadherin at the basolateral plasma membrane in polarized epithelia
    Kevin C Miranda
    Institute for Molecular Bioscience, School of Molecular and Microbial Sciences, University of Quensland, Brisbane, 4072 Queensland, Australia
    J Biol Chem 278:43480-8. 2003
    ..These findings help define the temporal assembly and sorting of the E-cadherin-catenin complex and show that membrane recruitment of p120ctn in polarized cells is contextual and confined to the basolateral membrane...
  12. pmc Tuba and N-WASP function cooperatively to position the central lumen during epithelial cyst morphogenesis
    Eva M Kovacs
    Division of Molecular Cell Biology, Institute for Molecular Bioscience, The University of Queensland St Lucia, QLD, Australia
    Cell Adh Migr 5:344-50. 2011
    ..Strikingly, both Tuba and N-WASP depend on each other for localization to the PAP. We conclude that N-WASP functions cooperatively with Tuba to facilitate lumenogenesis and this requires the polyproline region of N-WASP...
  13. pmc Myosin VI and vinculin cooperate during the morphogenesis of cadherin cell cell contacts in mammalian epithelial cells
    Madhavi P Maddugoda
    Division of Molecular Cell Biology, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane, Queensland, Australia
    J Cell Biol 178:529-40. 2007
    ..We propose that myosin VI and vinculin form a molecular apparatus that generates cohesive cell-cell contacts in cultured mammalian epithelia...
  14. doi request reprint N-WASP regulates the epithelial junctional actin cytoskeleton through a non-canonical post-nucleation pathway
    Eva M Kovacs
    Division of Molecular Cell Biology, Institute for Molecular Bioscience, School of Biomedical Sciences, The University of Queensland, St Lucia, Brisbane, Queensland 4072, Australia
    Nat Cell Biol 13:934-43. 2011
    ..We conclude that N-WASP-WIRE serves as an integrator that couples actin nucleation with the subsequent steps of filament stabilization and organization necessary for zonula adherens integrity...
  15. doi request reprint Productive tension: force-sensing and homeostasis of cell-cell junctions
    Guillermo A Gomez
    Division of Molecular Cell Biology, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane, Queensland, Australia 4072
    Trends Cell Biol 21:499-505. 2011
    ..In this review, we examine these advances and discuss their implications...
  16. pmc Cadherin adhesion receptors orient the mitotic spindle during symmetric cell division in mammalian epithelia
    Nicole den Elzen
    University of Queensland, Institute for Molecular Bioscience, St Lucia, Brisbane, Australia
    Mol Biol Cell 20:3740-50. 2009
    ..Together, these findings establish a novel morphogenetic function for cadherin adhesion receptors to guide spindle orientation during symmetric cell division...
  17. pmc Multicomponent analysis of junctional movements regulated by myosin II isoforms at the epithelial zonula adherens
    Michael Smutny
    Division of Molecular Cell Biology, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane, Queensland, Australia
    PLoS ONE 6:e22458. 2011
    ..This extends our recent analysis of Myosin II at the ZA to demonstrate that Myosin IIA and Myosin IIB make distinct contributions to junctional movement at the ZA...
  18. ncbi request reprint Rac is a dominant regulator of cadherin-directed actin assembly that is activated by adhesive ligation independently of Tiam1
    Astrid Kraemer
    Division of Molecular Cell Biology, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane, Queensland, Australia 4072
    Am J Physiol Cell Physiol 292:C1061-9. 2007
    ..We conclude that Rac1 critically influences cadherin-directed actin assembly as part of a signaling pathway independent of Tiam1...
  19. pmc Myosin II isoforms identify distinct functional modules that support integrity of the epithelial zonula adherens
    Michael Smutny
    Institute for Molecular Bioscience, Division of Molecular Cell Biology, The University of Queensland, St Lucia, Brisbane, Queensland 4072, Australia
    Nat Cell Biol 12:696-702. 2010
    ..We propose that these two isoform-based modules cooperate to coordinate adhesion receptor and F-actin organization to form apical cadherin junctions...
  20. ncbi request reprint Minimal mutation of the cytoplasmic tail inhibits the ability of E-cadherin to activate Rac but not phosphatidylinositol 3-kinase: direct evidence of a role for cadherin-activated Rac signaling in adhesion and contact formation
    Marita Goodwin
    School for Biomedical Sciences, The University of Queensland, St Lucia, Brisbane 4072, Queensland, Australia
    J Biol Chem 278:20533-9. 2003
    ..The molecular requirements for E-cadherin to activate Rac signaling thus appear distinct from those that stimulate PI3-kinase, and we postulate that p120-ctn may play a central role in the E-cadherin-Rac signaling pathway...
  21. pmc Myosin 2 is a key Rho kinase target necessary for the local concentration of E-cadherin at cell-cell contacts
    Annette M Shewan
    Division of Molecular Cell Biology, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Australia
    Mol Biol Cell 16:4531-42. 2005
    ..We propose that Myosin 2 is a key effector of Rho-Rho kinase signaling that regulates cell-cell adhesion by determining the ability of cells to concentrate cadherins at contacts in response to homophilic ligation...
  22. ncbi request reprint Recruitment of phosphoinositide 3-kinase defines a positive contribution of tyrosine kinase signaling to E-cadherin function
    Jian Hong Pang
    Division of Molecular Cell Biology, Institute for Molecular Bioscience and School for Biomedical Science, The University of Queensland, St Lucia, Brisbane, Queensland, Australia
    J Biol Chem 280:3043-50. 2005
    ..Taken together, our findings indicate that tyrosine kinase activity, notably Src signaling, can contribute positively to cadherin function by supporting E-cadherin signaling to PI 3-kinase...
  23. doi request reprint Hepatocyte growth factor acutely perturbs actin filament anchorage at the epithelial zonula adherens
    Sabine Mangold
    Division of Molecular Cell Biology, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane, Queensland 4072, Australia
    Curr Biol 21:503-7. 2011
    ..We conclude that regulators of the junctional cytoskeleton are likely to be major targets for cadherin junctions to be acutely modulated in development and perturbed in disease...
  24. doi request reprint Cortactin: Coordinating adhesion and the actin cytoskeleton at cellular protrusions
    Gang Ren
    Institute for Molecular Bioscience, Division of Molecular Cell Biology, The University of Queensland, St Lucia, Brisbane, Queensland, Australia 4072
    Cell Motil Cytoskeleton 66:865-73. 2009
    ..We further argue that regulatory proteins, such as cortactin, serve to coordinate the molecular components of this protrusive apparatus into a cohesive module...
  25. ncbi request reprint Cadherin-directed actin assembly: E-cadherin physically associates with the Arp2/3 complex to direct actin assembly in nascent adhesive contacts
    Eva M Kovacs
    Department of Physiology and Pharmacology, School of Biomedical Science, 4072, Brisbane, Australia
    Curr Biol 12:379-82. 2002
    ....
  26. ncbi request reprint Characterization of E-cadherin endocytosis in isolated MCF-7 and chinese hamster ovary cells: the initial fate of unbound E-cadherin
    Andrew D Paterson
    School for Biomedical Science, The University of Queensland, St Lucia, Brisbane, Australia 4072
    J Biol Chem 278:21050-7. 2003
    ..Taken with earlier reports, this suggests the possibility that multiple pathways exist for E-cadherin entry into cells that are likely to reflect cell context and regulation...
  27. ncbi request reprint Protein kinase C regulates endocytosis and recycling of E-cadherin
    Tam Luan Le
    Institute for Molecular Bioscience, Department of Biochemistry, University of Queensland, Brisbane 4072, Queensland, Australia
    Am J Physiol Cell Physiol 283:C489-99. 2002
    ..Our findings show that PKC regulates vital steps of E-cadherin trafficking, its endocytosis, and its recycling...
  28. ncbi request reprint The web and the rock: cell adhesion and the ARP2/3 complex
    Eva M Kovacs
    School for Biomedical Science, The University of Queensland, St Lucia, Brisbane, Australia
    Dev Cell 3:760-1. 2002
    ..A new paper by DeMali et al. provides new insights into the link between actin assembly and integrin adhesion at the leading edges of migrating cells...
  29. doi request reprint Cell-cell contact: cooperating clusters of actin and cadherin
    Eva M Kovacs
    Diamantina Institute for Cancer, Immunology and Metabolic Medicine, University of Queensland, St Lucia, Brisbane, Australia 4072
    Curr Biol 18:R667-R669. 2008
    ..Cooperation between cadherins and actin critically influences tissue organization. A new report identifies distinct pools of actin filaments that influence the spatial distribution of cadherins at cell-cell contacts...
  30. ncbi request reprint Dynamin-dependent endocytosis is necessary for convergent-extension movements in Xenopus animal cap explants
    Oliver Jarrett
    Department of Anatomy and Developmental Biology, School of Biomedical Sciences, University of Queensland, Brisbane, Australia
    Int J Dev Biol 46:467-73. 2002
    ..We propose that dynamin-dependent endocytosis of C-cadherin plays an important role in remodelling adhesive contacts during convergence-extension movements in the early Xenopus embryo...
  31. doi request reprint A bigger picture: classical cadherins and the dynamic actin cytoskeleton
    Aparna Ratheesh
    Division of Molecular Cell Biology, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane, Australia
    Nat Rev Mol Cell Biol 13:673-9. 2012
    ..Recent developments in understanding how filament dynamics and organization in the junctional cytoskeleton are controlled provide new insights into how the actin cytoskeleton regulates cadherin junctions in health and disease...
  32. ncbi request reprint Classical cadherin adhesion molecules: coordinating cell adhesion, signaling and the cytoskeleton
    Marita Goodwin
    Division of Molecular Cell Biology, Institute for Molecular Bioscience School for Biomedical Science, The University of Queensland, St Lucia, Australia 4072
    J Mol Histol 35:839-44. 2004
    ..We will review some of these developments, to provide an overview of progress in this rapidly-developing area of cell and developmental biology...
  33. ncbi request reprint Microtubules and cadherins: a neglected partnership
    Samantha J Stehbens
    Division of Molecular Cell Biology, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane, Queensland, Australia 4072
    Front Biosci (Landmark Ed) 14:3159-67. 2009
    ..Ultimately, we hope this will stimulate fresh interest and research to understand a neglected partnership...
  34. doi request reprint An α-catenin déjà vu
    Siew Ping Han
    Division of Molecular Cell Biology, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane 4072, Australia
    Nat Cell Biol 15:238-9. 2013
    ..A structure-function analysis in Drosophila melanogaster illuminates how the molecular properties of α-catenin translate into functional outcomes in an intact organism...
  35. ncbi request reprint Cinderella no longer: alpha-catenin steps out of cadherin's shadow
    Jeanie A Scott
    Division of Molecular Cell Biology, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane, Queensland, Australia
    J Cell Sci 119:4599-605. 2006
    ..alpha-catenin has a role in regulating cell proliferation and cadherin-independent pools of alpha-catenin may contribute to its functional impact...
  36. pmc Direct cadherin-activated cell signaling: a view from the plasma membrane
    Alpha S Yap
    School for Biomedical Science and Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane, Australia 4072
    J Cell Biol 160:11-6. 2003
    ..Recent developments indicate that classical cadherins are adhesion-activated signaling receptors. In particular, early-immediate Rac signaling is emerging as a mechanism to coordinate cadherin-actin integration at the plasma membrane...
  37. doi request reprint Protein tyrosine phosphatase activity is necessary for E-cadherin-activated Src signaling
    Robert W McLachlan
    Institute for Molecular Bioscience, Division of Molecular Cell Biology, The University of Queensland, St Lucia, Brisbane, Queensland, Australia 4072
    Cytoskeleton (Hoboken) 68:32-43. 2011
    ..We conclude that PTP-activated Src signaling is a possible upstream regulator of myosin IIB at the epithelial zonula adherens...
  38. pmc The SNX-PX-BAR family in macropinocytosis: the regulation of macropinosome formation by SNX-PX-BAR proteins
    Jack T H Wang
    Institute for Molecular Bioscience and Australia Research Council, Centre of Excellence in Bioinformatics, The University of Queensland, St Lucia, Brisbane, Australia
    PLoS ONE 5:e13763. 2010
    ..SNX-PX-BAR proteins form a subset of the SNX family and their lipid-binding (PX) and membrane-curvature sensing (BAR) domain architecture further implicates their functional involvement in macropinosome formation...
  39. pmc Neighborly relations: cadherins and mechanotransduction
    Michael Smutny
    Institute for Molecular Bioscience, Division of Molecular Cell Biology, The University of Queensland, St Lucia, Brisbane, Queensland, Australia 4072
    J Cell Biol 189:1075-7. 2010
    ..2010. J. Cell Biol. doi: 10.1083/jcb.201001149) provide direct evidence that E-cadherin participates in a mechanosensing pathway that regulates the actomyosin cytoskeleton to modulate cell stiffness in response to pulling force...
  40. pmc Epstein-Barr virus associated modulation of Wnt pathway is not dependent on latent membrane protein-1
    Natasha Webb
    Australian Centre for Vaccine Development and Tumour Immunology Laboratory, Division of Infectious Diseases and Immunology, Queensland Institute of Medical Research, Brisbane, Australia
    PLoS ONE 3:e3254. 2008
    ..Taken together these studies demonstrate that EBV-mediated activation of Wnt pathway is not dependent on the expression of LMP1...
  41. pmc Coupling adhesion to actin bundles in the inner ear. Novel functions for novel cadherins
    Astrid Kraemer
    Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane, Queensland 4072, Australia
    EMBO Rep 4:244-5. 2003
  42. ncbi request reprint Not so simple: the complexity of phosphotyrosine signaling at cadherin adhesive contacts
    Robert W McLachlan
    Division of Molecular Cell Biology, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane, Queensland, 4072, Australia
    J Mol Med (Berl) 85:545-54. 2007
    ....
  43. doi request reprint Coordinating Rho and Rac: the regulation of Rho GTPase signaling and cadherin junctions
    Aparna Ratheesh
    Division of Molecular Cell Biology, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane, Australia
    Prog Mol Biol Transl Sci 116:49-68. 2013
    ....
  44. doi request reprint Vinculin, cadherin mechanotransduction and homeostasis of cell-cell junctions
    Joanne M Leerberg
    Division of Molecular Cell Biology, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane, Queensland, Australia, 4072
    Protoplasma 250:817-29. 2013
    ..Vinculin has emerged as an important element in cadherin mechanotransduction, a perspective that illuminates its role in cell-cell interactions. We now review its role as a cortical scaffold and its role in cadherin mechanotransduction. ..
  45. doi request reprint The regulation and functional impact of actin assembly at cadherin cell-cell adhesions
    Magdalene Michael
    Division of Molecular Cell Biology, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane, Queensland 4072, Australia Electronic address
    Semin Cell Dev Biol 24:298-307. 2013
    ..This review highlights the molecular machinery implicated in actin organisation at various stages of junctional assembly and its functional impact in simple epithelia and other model systems...
  46. ncbi request reprint E-cadherin homophilic ligation directly signals through Rac and phosphatidylinositol 3-kinase to regulate adhesive contacts
    Eva M Kovacs
    Department of Physiology and Pharmacology, School of Biomedical Science, The University of Queensland, St Lucia, Brisbane, Queensland 4072, Australia
    J Biol Chem 277:6708-18. 2002
    ..We propose that a key function of these cadherin-activated signals is to control adhesive contacts, probably via regulation of the actin cytoskeleton, which ultimately serves to mediate adhesive cell-cell recognition...
  47. pmc Traffic control: p120-catenin acts as a gatekeeper to control the fate of classical cadherins in mammalian cells
    Mark Peifer
    Department of Biology and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 3280, USA
    J Cell Biol 163:437-40. 2003
    ..2003; Davis et al., 2003; Xiao et al., 2003)...
  48. ncbi request reprint Another job for the talented p120-catenin
    Carien M Niessen
    Center for Molecular Medicine Cologne CMMC, University of Cologne, Joseph Stelzmannstrasse 9, 50931 Cologne
    Cell 127:875-7. 2006
    ..In this issue of Cell, Wildenberg et al. (2006) reveal that the key effector molecule p120-catenin can mediate crosstalk between the Rac and Rho signaling pathways...
  49. ncbi request reprint HOXA1 is required for E-cadherin-dependent anchorage-independent survival of human mammary carcinoma cells
    Xin Zhang
    Department of Medicine and Institute of Molecular and Cell Biology, National University of Singapore, 30 Medical Dr, Singapore 117609, Republic of Singapore
    J Biol Chem 281:6471-81. 2006
    ..HOXA1 is therefore a downstream effector of E-cadherin-directed signaling required for anchorage-independent proliferation of mammary carcinoma cells...
  50. ncbi request reprint When domestiques rebel: kinesins, cadherins and neuronal proliferation
    Cara J Gottardi
    Nat Cell Biol 7:445-7. 2005
  51. ncbi request reprint The challenges of abundance: epithelial junctions and small GTPase signalling
    Vania Mm Braga
    Cell and Molecular Biology Section, Division of Biomedical Sciences, Faculty of Life Sciences, Imperial College London, SW7 2AZ, London
    Curr Opin Cell Biol 17:466-74. 2005
    ....