Zhiguang Xiao

Summary

Affiliation: University of Melbourne
Country: Australia

Publications

  1. ncbi request reprint Redox sulfur chemistry of the copper chaperone Atox1 is regulated by the enzyme glutaredoxin 1, the reduction potential of the glutathione couple GSSG/2GSH and the availability of Cu(I)
    Jens Brose
    School of Chemistry and The Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria 3010, Australia
    Metallomics 6:793-808. 2014
  2. doi request reprint Evaluation of quantitative probes for weaker Cu(i) binding sites completes a set of four capable of detecting Cu(i) affinities from nanomolar to attomolar
    Zhiguang Xiao
    School of Chemistry, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria 3010, Australia
    Metallomics 5:501-13. 2013
  3. pmc Unification of the copper(I) binding affinities of the metallo-chaperones Atx1, Atox1, and related proteins: detection probes and affinity standards
    Zhiguang Xiao
    School of Chemistry and Bio21 Institute, University of Melbourne, Victoria, Australia
    J Biol Chem 286:11047-55. 2011
  4. doi request reprint The challenges of determining metal-protein affinities
    Zhiguang Xiao
    University of Melbourne, Parkville, Victoria, Australia
    Nat Prod Rep 27:768-89. 2010
  5. ncbi request reprint Redox thermodynamics of mutant forms of the rubredoxin from Clostridiumpasteurianum: identification of a stable Fe(III)(S-Cys)3(OH) centre in the C6S mutant
    Z Xiao
    School of Chemistry, University of Melbourne, Parkville, Victoria, Australia
    J Biol Inorg Chem 6:638-49. 2001
  6. doi request reprint Transfer of copper between bis(thiosemicarbazone) ligands and intracellular copper-binding proteins. insights into mechanisms of copper uptake and hypoxia selectivity
    Zhiguang Xiao
    School of Chemistry and Bio21 Molecular Science and Biotechnology Institute, 30 Flemington Road, University of Melbourne, Parkville, Victoria 3010, Australia
    Inorg Chem 47:4338-47. 2008
  7. ncbi request reprint C-terminal domain of the membrane copper transporter Ctr1 from Saccharomyces cerevisiae binds four Cu(I) ions as a cuprous-thiolate polynuclear cluster: sub-femtomolar Cu(I) affinity of three proteins involved in copper trafficking
    Zhiguang Xiao
    School of Chemistry, University of Melbourne, Victoria, 3010, Australia
    J Am Chem Soc 126:3081-90. 2004
  8. doi request reprint Interaction of cisplatin and analogue Pt(en)Cl2 with the copper metallo-chaperone Atox1
    Chak Ming Sze
    School of Chemistry and Bio21 Institute, University of Melbourne, Victoria 3010, Australia
    Metallomics 5:946-54. 2013
  9. doi request reprint PcoE--a metal sponge expressed to the periplasm of copper resistance Escherichia coli. Implication of its function role in copper resistance
    Matthias Zimmermann
    School of Chemistry, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria 3010, Australia
    J Inorg Biochem 115:186-97. 2012
  10. doi request reprint Electron paramagnetic resonance characterization of the copper-resistance protein PcoC from Escherichia coli
    Simon C Drew
    Department of Pathology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, VIC 3010, Australia
    J Biol Inorg Chem 13:899-907. 2008

Collaborators

Detail Information

Publications26

  1. ncbi request reprint Redox sulfur chemistry of the copper chaperone Atox1 is regulated by the enzyme glutaredoxin 1, the reduction potential of the glutathione couple GSSG/2GSH and the availability of Cu(I)
    Jens Brose
    School of Chemistry and The Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria 3010, Australia
    Metallomics 6:793-808. 2014
    ..These proteins appear to have evolved the features necessary to fill multiple roles in redox regulation, Cu(I) buffering and Cu(I) transport...
  2. doi request reprint Evaluation of quantitative probes for weaker Cu(i) binding sites completes a set of four capable of detecting Cu(i) affinities from nanomolar to attomolar
    Zhiguang Xiao
    School of Chemistry, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria 3010, Australia
    Metallomics 5:501-13. 2013
    ..Selected examples of quantification of weaker Cu(i) binding in proteins and peptides are provided, including that of an amyloid-β peptide...
  3. pmc Unification of the copper(I) binding affinities of the metallo-chaperones Atx1, Atox1, and related proteins: detection probes and affinity standards
    Zhiguang Xiao
    School of Chemistry and Bio21 Institute, University of Melbourne, Victoria, Australia
    J Biol Chem 286:11047-55. 2011
    ....
  4. doi request reprint The challenges of determining metal-protein affinities
    Zhiguang Xiao
    University of Melbourne, Parkville, Victoria, Australia
    Nat Prod Rep 27:768-89. 2010
    ..This review surveys possible approaches to estimation of these dissociation constants and pinpoints the various problems associated with each approach...
  5. ncbi request reprint Redox thermodynamics of mutant forms of the rubredoxin from Clostridiumpasteurianum: identification of a stable Fe(III)(S-Cys)3(OH) centre in the C6S mutant
    Z Xiao
    School of Chemistry, University of Melbourne, Parkville, Victoria, Australia
    J Biol Inorg Chem 6:638-49. 2001
    ..ph<pka: [fe(iii)(s-cys)3(oh)]- +h+ e- --> [fe(ii)(s-cys)3(oh2)]-...
  6. doi request reprint Transfer of copper between bis(thiosemicarbazone) ligands and intracellular copper-binding proteins. insights into mechanisms of copper uptake and hypoxia selectivity
    Zhiguang Xiao
    School of Chemistry and Bio21 Molecular Science and Biotechnology Institute, 30 Flemington Road, University of Melbourne, Parkville, Victoria 3010, Australia
    Inorg Chem 47:4338-47. 2008
    ..The more reducing environment of hypoxic cells leads to reduction of Cu(II)(Atsm) and retention of its copper...
  7. ncbi request reprint C-terminal domain of the membrane copper transporter Ctr1 from Saccharomyces cerevisiae binds four Cu(I) ions as a cuprous-thiolate polynuclear cluster: sub-femtomolar Cu(I) affinity of three proteins involved in copper trafficking
    Zhiguang Xiao
    School of Chemistry, University of Melbourne, Victoria, 3010, Australia
    J Am Chem Soc 126:3081-90. 2004
    ..In addition, both Ctr1c and its copper-responsive transcription factor Mac1 contain similar clusters which may be important in signaling copper status in yeast...
  8. doi request reprint Interaction of cisplatin and analogue Pt(en)Cl2 with the copper metallo-chaperone Atox1
    Chak Ming Sze
    School of Chemistry and Bio21 Institute, University of Melbourne, Victoria 3010, Australia
    Metallomics 5:946-54. 2013
    ..The analysis, based on the entire isotope patterns, is consistent with the cysteine residues in the Cu(I)-binding sequence Cys(12)GlyGlyCys(15) being the primary coordination site. ..
  9. doi request reprint PcoE--a metal sponge expressed to the periplasm of copper resistance Escherichia coli. Implication of its function role in copper resistance
    Matthias Zimmermann
    School of Chemistry, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria 3010, Australia
    J Inorg Biochem 115:186-97. 2012
    ....
  10. doi request reprint Electron paramagnetic resonance characterization of the copper-resistance protein PcoC from Escherichia coli
    Simon C Drew
    Department of Pathology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, VIC 3010, Australia
    J Biol Inorg Chem 13:899-907. 2008
    ..The markedly different spectra of the H1F and nA forms compared with the wild-type and H92F proteins further highlight the integral role of the N-terminal histidine residue in the high-affinity Cu(II) site of PcoC...
  11. doi request reprint Reaction mechanisms of the multicopper oxidase CueO from Escherichia coli support its functional role as a cuprous oxidase
    Karrera Y Djoko
    School of Chemistry and Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria 3010, Australia
    J Am Chem Soc 132:2005-15. 2010
    ..The results provide compelling evidence that CueO is a cuprous oxidase. The new approach will have significant application to the study of metallo-oxidase enzymes...
  12. doi request reprint Copper complexes of a novel non-innocent quadridentate ligand
    Gojko Buncic
    School of Chemistry and Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria 3010, Australia
    Chem Commun (Camb) 48:2570-2. 2012
    ....
  13. ncbi request reprint Intermolecular transfer of copper ions from the CopC protein of Pseudomonas syringae. Crystal structures of fully loaded Cu(I)Cu(II) forms
    Lianyi Zhang
    School of Chemistry and Bio21 Institute, University of Melbourne, Parkville, VIC 3010, Australia
    J Am Chem Soc 128:5834-50. 2006
    ..CopC has the potential to interact directly with each of the four cop proteins coexpressed to the periplasm...
  14. doi request reprint Metal binding affinities of Arabidopsis zinc and copper transporters: selectivities match the relative, but not the absolute, affinities of their amino-terminal domains
    Matthias Zimmermann
    School of Chemistry, University of Melbourne, Parkville, Victoria 3010, Australia
    Biochemistry 48:11640-54. 2009
    ..Each Zn(II) ion occupied a distorted tetrahedral site formed from two Cys ligands of the CxxC motif of one HMA7n molecule and the amino N and carbonyl O atoms of the N-terminal methionine of another...
  15. doi request reprint Interaction of cisplatin and analogues with a Met-rich protein site
    Chak Ming Sze
    School of Chemistry and the Bio21 Institute, University of Melbourne, Melbourne, Vic, 3010, Australia
    J Biol Inorg Chem 14:163-5. 2009
    ..It focuses attention on the potential of proteins that are part of the natural copper transport pathways to sequester the drug. These pathways are worthy of further study at the molecular level...
  16. doi request reprint Copper resistance in E. coli: the multicopper oxidase PcoA catalyzes oxidation of copper(I) in Cu(I)Cu(II)-PcoC
    Karrera Y Djoko
    School of Chemistry and Bio21 Research Institute, University of Melbourne, Parkville, Victoria 3010, Australia
    Chembiochem 9:1579-82. 2008
  17. ncbi request reprint Conserved mechanism of copper binding and transfer. A comparison of the copper-resistance proteins PcoC from Escherichia coli and CopC from Pseudomonas syringae
    Karrera Y Djoko
    School of Chemistry, University of Melbourne, Parkville, Victoria 3052, Australia
    Inorg Chem 46:4560-8. 2007
    ..Access to a bona fide wild-type PcoC protein allowed unequivocal observation of intermediates involved in intermolecular redox copper transfer reactions...
  18. doi request reprint A water-soluble bis(thiosemicarbazone) ligand. a sensitive probe and metal buffer for zinc
    Gojko Buncic
    School of Chemistry and Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria 3010, Australia
    Inorg Chem 49:3071-3. 2010
    ..Its potential application as a chromophoric probe was demonstrated by estimation of the Zn(II) binding affinities of the soluble metal-binding domains of two plant metal-transporting proteins...
  19. ncbi request reprint Removal of a cysteine ligand from rubredoxin: assembly of Fe(2)S(2) and Fe(S-Cys)(3)(OH) centres
    Maddalena Cross
    School of Chemistry, University of Melbourne, Parkville, Victoria 3010, Australia
    J Biol Inorg Chem 7:781-90. 2002
    ..In addition to Fe(S-Cys)(3)(OH) centres, the C9G, C42G and C42A preparations contain a second four-coordinate Fe(III)form in which a ligand appears to be supplied by the protein chain...
  20. doi request reprint Unprecedented binding cooperativity between Cu(I) and Cu(II) in the copper resistance protein CopK from Cupriavidus metallidurans CH34: implications from structural studies by NMR spectroscopy and X-ray crystallography
    Lee Xin Chong
    School of Chemistry and, Biomolecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria 3010, Australia
    J Am Chem Soc 131:3549-64. 2009
    ..This information provides a valuable guide to the role of CopK in copper resistance...
  21. ncbi request reprint CopC protein from Pseudomonas syringae: intermolecular transfer of copper from both the copper(I) and copper(II) sites
    Melissa Koay
    School of Chemistry, University of Melbourne, Victoria 3010, Australia
    Inorg Chem 44:5203-5. 2005
    ..These properties would allow it to exchange either Cu(I) or Cu(II) with its putative partners CopA, CopB, and CopD, contrasting with the role of the Cu(I) (only) chaperones found in the reducing cytoplasm...
  22. doi request reprint Quantification of copper binding to amyloid precursor protein domain 2 and its Caenorhabditis elegans ortholog. Implications for biological function
    Su Ling Leong
    The Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Victoria 3010, Australia
    Metallomics 6:105-16. 2014
    ..elegans. Overall, the data are consistent with a possible role in copper homeostasis for APP-D2, but not APL1-D2...
  23. ncbi request reprint Copper and Alzheimer's disease
    Paul S Donnelly
    School of Chemistry, University of Melbourne, Parkville, Victoria 3010, Australia
    Curr Opin Chem Biol 11:128-33. 2007
    ..When coupled to misfolded proteins, this modified copper homeostasis appears to be an important factor in the pathological progression of AD...
  24. doi request reprint An integrated study of the affinities of the Aβ16 peptide for Cu(I) and Cu(II): implications for the catalytic production of reactive oxygen species
    Tessa R Young
    The Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Victoria 3010, Australia
    Metallomics 6:505-17. 2014
    ..These new thermodynamic data strengthen structural interpretations for the Cu-Aβ complexes and provide valuable insights into the molecular mechanism by which copper chemistry may induce oxidative stress in Alzheimer's disease...
  25. pmc Application of NMRD to hydration of rubredoxin and a variant containing a (Cys-S)3FeIII(OH) site
    Ivano Bertini
    CERM and Department of Chemistry, University of Florence, Via Luigi Sacconi 6, 50019 Sesto Fiorentino, Italy
    Biophys J 84:545-51. 2003
    ..1)H nuclear magnetic relaxation dispersion profiles indicate increased hydration with respect to the wild-type...
  26. ncbi request reprint Protonless 13C direct detection NMR: characterization of the 37 kDa trimeric protein CutA1
    Ivano Bertini
    Magnetic Resonance Center, University of Florence, Sesto Fiorentino, Italy
    Proteins 70:1196-205. 2008
    ..The structural and dynamical knowledge obtained for this system may contribute to understand its biological role...