Research Topics
| Zhiguang XiaoSummaryAffiliation: University of Melbourne Country: Australia Publications
| Collaborators
|
Detail Information
Publications
Evaluation of quantitative probes for weaker Cu(i) binding sites completes a set of four capable of detecting Cu(i) affinities from nanomolar to attomolarZhiguang Xiao
School of Chemistry, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria 3010, Australia
Metallomics 5:501-13. 2013..Selected examples of quantification of weaker Cu(i) binding in proteins and peptides are provided, including that of an amyloid-β peptide...
Unification of the copper(I) binding affinities of the metallo-chaperones Atx1, Atox1, and related proteins: detection probes and affinity standardsZhiguang Xiao
School of Chemistry and Bio21 Institute, University of Melbourne, Victoria, Australia
J Biol Chem 286:11047-55. 2011....- The challenges of determining metal-protein affinitiesZhiguang Xiao
University of Melbourne, Parkville, Victoria, Australia
Nat Prod Rep 27:768-89. 2010..This review surveys possible approaches to estimation of these dissociation constants and pinpoints the various problems associated with each approach... 
Redox thermodynamics of mutant forms of the rubredoxin from Clostridiumpasteurianum: identification of a stable Fe(III)(S-Cys)3(OH) centre in the C6S mutantZ Xiao
School of Chemistry, University of Melbourne, Parkville, Victoria, Australia
J Biol Inorg Chem 6:638-49. 2001..ph<pka: [fe(iii)(s-cys)3(oh)]- +h+ e- --> [fe(ii)(s-cys)3(oh2)]-...- Transfer of copper between bis(thiosemicarbazone) ligands and intracellular copper-binding proteins. insights into mechanisms of copper uptake and hypoxia selectivityZhiguang Xiao
School of Chemistry and Bio21 Molecular Science and Biotechnology Institute, 30 Flemington Road, University of Melbourne, Parkville, Victoria 3010, Australia
Inorg Chem 47:4338-47. 2008..The more reducing environment of hypoxic cells leads to reduction of Cu(II)(Atsm) and retention of its copper... - C-terminal domain of the membrane copper transporter Ctr1 from Saccharomyces cerevisiae binds four Cu(I) ions as a cuprous-thiolate polynuclear cluster: sub-femtomolar Cu(I) affinity of three proteins involved in copper traffickingZhiguang Xiao
School of Chemistry, University of Melbourne, Victoria, 3010, Australia
J Am Chem Soc 126:3081-90. 2004..In addition, both Ctr1c and its copper-responsive transcription factor Mac1 contain similar clusters which may be important in signaling copper status in yeast... - PcoE--a metal sponge expressed to the periplasm of copper resistance Escherichia coli. Implication of its function role in copper resistanceMatthias Zimmermann
School of Chemistry, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria 3010, Australia
J Inorg Biochem 115:186-97. 2012.... - Reaction mechanisms of the multicopper oxidase CueO from Escherichia coli support its functional role as a cuprous oxidaseKarrera Y Djoko
School of Chemistry and Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria 3010, Australia
J Am Chem Soc 132:2005-15. 2010..The results provide compelling evidence that CueO is a cuprous oxidase. The new approach will have significant application to the study of metallo-oxidase enzymes... - Electron paramagnetic resonance characterization of the copper-resistance protein PcoC from Escherichia coliSimon C Drew
Department of Pathology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, VIC 3010, Australia
J Biol Inorg Chem 13:899-907. 2008..The markedly different spectra of the H1F and nA forms compared with the wild-type and H92F proteins further highlight the integral role of the N-terminal histidine residue in the high-affinity Cu(II) site of PcoC... - Copper complexes of a novel non-innocent quadridentate ligandGojko Buncic
School of Chemistry and Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria 3010, Australia
Chem Commun (Camb) 48:2570-2. 2012.... - Intermolecular transfer of copper ions from the CopC protein of Pseudomonas syringae. Crystal structures of fully loaded Cu(I)Cu(II) formsLianyi Zhang
School of Chemistry and Bio21 Institute, University of Melbourne, Parkville, VIC 3010, Australia
J Am Chem Soc 128:5834-50. 2006..CopC has the potential to interact directly with each of the four cop proteins coexpressed to the periplasm... - Metal binding affinities of Arabidopsis zinc and copper transporters: selectivities match the relative, but not the absolute, affinities of their amino-terminal domainsMatthias Zimmermann
School of Chemistry, University of Melbourne, Parkville, Victoria 3010, Australia
Biochemistry 48:11640-54. 2009..Each Zn(II) ion occupied a distorted tetrahedral site formed from two Cys ligands of the CxxC motif of one HMA7n molecule and the amino N and carbonyl O atoms of the N-terminal methionine of another... - Copper resistance in E. coli: the multicopper oxidase PcoA catalyzes oxidation of copper(I) in Cu(I)Cu(II)-PcoCKarrera Y Djoko
School of Chemistry and Bio21 Research Institute, University of Melbourne, Parkville, Victoria 3010, Australia
Chembiochem 9:1579-82. 2008 - Interaction of cisplatin and analogues with a Met-rich protein siteChak Ming Sze
School of Chemistry and the Bio21 Institute, University of Melbourne, Melbourne, Vic, 3010, Australia
J Biol Inorg Chem 14:163-5. 2009..It focuses attention on the potential of proteins that are part of the natural copper transport pathways to sequester the drug. These pathways are worthy of further study at the molecular level... - A water-soluble bis(thiosemicarbazone) ligand. a sensitive probe and metal buffer for zincGojko Buncic
School of Chemistry and Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria 3010, Australia
Inorg Chem 49:3071-3. 2010..Its potential application as a chromophoric probe was demonstrated by estimation of the Zn(II) binding affinities of the soluble metal-binding domains of two plant metal-transporting proteins... - Conserved mechanism of copper binding and transfer. A comparison of the copper-resistance proteins PcoC from Escherichia coli and CopC from Pseudomonas syringaeKarrera Y Djoko
School of Chemistry, University of Melbourne, Parkville, Victoria 3052, Australia
Inorg Chem 46:4560-8. 2007..Access to a bona fide wild-type PcoC protein allowed unequivocal observation of intermediates involved in intermolecular redox copper transfer reactions... - Removal of a cysteine ligand from rubredoxin: assembly of Fe(2)S(2) and Fe(S-Cys)(3)(OH) centresMaddalena Cross
School of Chemistry, University of Melbourne, Parkville, Victoria 3010, Australia
J Biol Inorg Chem 7:781-90. 2002..In addition to Fe(S-Cys)(3)(OH) centres, the C9G, C42G and C42A preparations contain a second four-coordinate Fe(III)form in which a ligand appears to be supplied by the protein chain... - Unprecedented binding cooperativity between Cu(I) and Cu(II) in the copper resistance protein CopK from Cupriavidus metallidurans CH34: implications from structural studies by NMR spectroscopy and X-ray crystallographyLee Xin Chong
School of Chemistry and, Biomolecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria 3010, Australia
J Am Chem Soc 131:3549-64. 2009..This information provides a valuable guide to the role of CopK in copper resistance... - CopC protein from Pseudomonas syringae: intermolecular transfer of copper from both the copper(I) and copper(II) sitesMelissa Koay
School of Chemistry, University of Melbourne, Victoria 3010, Australia
Inorg Chem 44:5203-5. 2005..These properties would allow it to exchange either Cu(I) or Cu(II) with its putative partners CopA, CopB, and CopD, contrasting with the role of the Cu(I) (only) chaperones found in the reducing cytoplasm... - Copper and Alzheimer's diseasePaul S Donnelly
School of Chemistry, University of Melbourne, Parkville, Victoria 3010, Australia
Curr Opin Chem Biol 11:128-33. 2007..When coupled to misfolded proteins, this modified copper homeostasis appears to be an important factor in the pathological progression of AD... - Application of NMRD to hydration of rubredoxin and a variant containing a (Cys-S)3FeIII(OH) siteIvano Bertini
CERM and Department of Chemistry, University of Florence, Via Luigi Sacconi 6, 50019 Sesto Fiorentino, Italy
Biophys J 84:545-51. 2003..1)H nuclear magnetic relaxation dispersion profiles indicate increased hydration with respect to the wild-type... - Protonless 13C direct detection NMR: characterization of the 37 kDa trimeric protein CutA1Ivano Bertini
Magnetic Resonance Center, University of Florence, Sesto Fiorentino, Italy
Proteins 70:1196-205. 2008..The structural and dynamical knowledge obtained for this system may contribute to understand its biological role...