C J Xian

Summary

Affiliation: University of Adelaide
Country: Australia

Publications

  1. ncbi request reprint TNF-alpha mediates p38 MAP kinase activation and negatively regulates bone formation at the injured growth plate in rats
    Fiona H Zhou
    Department of Orthopaedic Surgery, Women s and Children s Hospital, North Adelaide, South Australia
    J Bone Miner Res 21:1075-88. 2006
  2. ncbi request reprint Effects of TGF-alpha gene knockout on epithelial cell kinetics and repair of methotrexate-induced damage in mouse small intestine
    Cory J Xian
    Child Health Research Institute and Cooperative Research Centre for Tissue Growth and Repair, North Adelaide, South Australia, Australia
    J Cell Physiol 191:105-15. 2002
  3. ncbi request reprint Roles of growth factors in chemotherapy-induced intestinal mucosal damage repair
    C J Xian
    Department of Orthopaedic Surgery, and University of Adelaide Department of Paediatrics, Women s and Children s Hospital, North Adelaide 5006, Australia
    Curr Pharm Biotechnol 4:260-9. 2003
  4. ncbi request reprint Intramembranous ossification mechanism for bone bridge formation at the growth plate cartilage injury site
    Cory J Xian
    Department of Orthopaedic Surgery, and University of Adelaide Department of Paediatrics, Women s and Children s Hospital, 72 King William Road, North Adelaide 5006, Australia
    J Orthop Res 22:417-26. 2004
  5. ncbi request reprint Effects of acute 5-fluorouracil chemotherapy and insulin-like growth factor-I pretreatment on growth plate cartilage and metaphyseal bone in rats
    C J Xian
    Department of Orthopaedic Surgery, University of Adelaide Department of Paediatrics, North Adelaide, SA, Australia
    Bone 35:739-49. 2004
  6. ncbi request reprint Damage and recovery of the bone growth mechanism in young rats following 5-fluorouracil acute chemotherapy
    Cory J Xian
    Department of Orthopaedic Surgery, University of Adelaide Department of Paediatrics, Women s and Children s Hospital, 72 King William Road, North Adelaide, SA 5006, Australia
    J Cell Biochem 99:1688-704. 2006
  7. ncbi request reprint Lack of effects of transforming growth factor-alpha gene knockout on peripheral nerve regeneration may result from compensatory mechanisms
    C J Xian
    Department of Human Physiology, Flinders University of South Australia, Adelaide 5001, Australia
    Exp Neurol 172:182-8. 2001
  8. ncbi request reprint Effects of etoposide and cyclophosphamide acute chemotherapy on growth plate and metaphyseal bone in rats
    Cory J Xian
    Department of Orthopaedic Surgery, University of Adelaide Department of Paediatrics, Women s and Children s Hospital, 72 King William Road, North Adelaide, SA 5006, Australia
    Cancer Biol Ther 6:170-7. 2007
  9. ncbi request reprint Roles of epidermal growth factor family in the regulation of postnatal somatic growth
    Cory J Xian
    Department of Orthopaedic Surgery, Women s and Children s Hospital, 72 King William Road, North Adelaide, South Australia 5006, Australia
    Endocr Rev 28:284-96. 2007
  10. ncbi request reprint Folinic acid attenuates methotrexate chemotherapy-induced damages on bone growth mechanisms and pools of bone marrow stromal cells
    Cory J Xian
    Department of Orthopaedic Surgery, Women s and Children s Hospital, Adelaide, South Australia
    J Cell Physiol 214:777-85. 2008

Collaborators

Detail Information

Publications41

  1. ncbi request reprint TNF-alpha mediates p38 MAP kinase activation and negatively regulates bone formation at the injured growth plate in rats
    Fiona H Zhou
    Department of Orthopaedic Surgery, Women s and Children s Hospital, North Adelaide, South Australia
    J Bone Miner Res 21:1075-88. 2006
    ..The results show that TNF-alpha mediates p38 activation, which influences the recruitment, proliferation, and osteoblast differentiation of mesenchymal cells and negatively regulates bone formation at the injured growth plate...
  2. ncbi request reprint Effects of TGF-alpha gene knockout on epithelial cell kinetics and repair of methotrexate-induced damage in mouse small intestine
    Cory J Xian
    Child Health Research Institute and Cooperative Research Centre for Tissue Growth and Repair, North Adelaide, South Australia, Australia
    J Cell Physiol 191:105-15. 2002
    ....
  3. ncbi request reprint Roles of growth factors in chemotherapy-induced intestinal mucosal damage repair
    C J Xian
    Department of Orthopaedic Surgery, and University of Adelaide Department of Paediatrics, Women s and Children s Hospital, North Adelaide 5006, Australia
    Curr Pharm Biotechnol 4:260-9. 2003
    ....
  4. ncbi request reprint Intramembranous ossification mechanism for bone bridge formation at the growth plate cartilage injury site
    Cory J Xian
    Department of Orthopaedic Surgery, and University of Adelaide Department of Paediatrics, Women s and Children s Hospital, 72 King William Road, North Adelaide 5006, Australia
    J Orthop Res 22:417-26. 2004
    ..These results suggest that bone bridge formation after growth plate injury occurs directly via intramembranous ossification through recruitment of marrow-derived osteoprogenitor cells...
  5. ncbi request reprint Effects of acute 5-fluorouracil chemotherapy and insulin-like growth factor-I pretreatment on growth plate cartilage and metaphyseal bone in rats
    C J Xian
    Department of Orthopaedic Surgery, University of Adelaide Department of Paediatrics, North Adelaide, SA, Australia
    Bone 35:739-49. 2004
    ....
  6. ncbi request reprint Damage and recovery of the bone growth mechanism in young rats following 5-fluorouracil acute chemotherapy
    Cory J Xian
    Department of Orthopaedic Surgery, University of Adelaide Department of Paediatrics, Women s and Children s Hospital, 72 King William Road, North Adelaide, SA 5006, Australia
    J Cell Biochem 99:1688-704. 2006
    ....
  7. ncbi request reprint Lack of effects of transforming growth factor-alpha gene knockout on peripheral nerve regeneration may result from compensatory mechanisms
    C J Xian
    Department of Human Physiology, Flinders University of South Australia, Adelaide 5001, Australia
    Exp Neurol 172:182-8. 2001
    ....
  8. ncbi request reprint Effects of etoposide and cyclophosphamide acute chemotherapy on growth plate and metaphyseal bone in rats
    Cory J Xian
    Department of Orthopaedic Surgery, University of Adelaide Department of Paediatrics, Women s and Children s Hospital, 72 King William Road, North Adelaide, SA 5006, Australia
    Cancer Biol Ther 6:170-7. 2007
    ....
  9. ncbi request reprint Roles of epidermal growth factor family in the regulation of postnatal somatic growth
    Cory J Xian
    Department of Orthopaedic Surgery, Women s and Children s Hospital, 72 King William Road, North Adelaide, South Australia 5006, Australia
    Endocr Rev 28:284-96. 2007
    ..Finally, EGF-R ligands can regulate bone homeostasis by regulating a pool of progenitor cells in the bone marrow through promoting proliferation but suppressing differentiation of bone marrow mesenchymal stem cells...
  10. ncbi request reprint Folinic acid attenuates methotrexate chemotherapy-induced damages on bone growth mechanisms and pools of bone marrow stromal cells
    Cory J Xian
    Department of Orthopaedic Surgery, Women s and Children s Hospital, Adelaide, South Australia
    J Cell Physiol 214:777-85. 2008
    ....
  11. ncbi request reprint Cellular mechanisms for methotrexate chemotherapy-induced bone growth defects
    Cory J Xian
    Department of Orthopaedic Surgery, Women s and Children s Hospital, Adelaide, South Australia Discipline of Paediatrics, University of Adelaide, Australia
    Bone 41:842-50. 2007
    ..However, this short-term MTX treatment only caused transit suppressions on growth plate cartilage and trabecular bone, as most cellular and histological parameters had recovered by day 14 or 21...
  12. ncbi request reprint Repair of injured articular and growth plate cartilage using mesenchymal stem cells and chondrogenic gene therapy
    Cory J Xian
    Department of Orthopedic Surgery, and University of Adelaide Department of Paediatrics, Women s and Children s Hospital, North Adelaide 5006, Australia
    Curr Stem Cell Res Ther 1:213-29. 2006
    ....
  13. ncbi request reprint EGF family of growth factors: essential roles and functional redundancy in the nerve system
    Cory J Xian
    Department of Orthopaedic Surgery, Women s and Children s Hospital, Adelaide, Australia
    Front Biosci 9:85-92. 2004
    ..These studies have revealed that, despite a possible functional redundancy among the individual EGF family ligands, collectively EGF-R ligands are required for development and maintenance of the nerve system...
  14. ncbi request reprint Satellite-cell-derived nerve growth factor and neurotrophin-3 are involved in noradrenergic sprouting in the dorsal root ganglia following peripheral nerve injury in the rat
    X F Zhou
    Department of Human Physiology and Centre for Neuroscience, Flinders University of South Australia, Adelaide, Australia
    Eur J Neurosci 11:1711-22. 1999
    ..These results implicate satellite cell-derived neurotrophins in the induction of sympathetic sprouting following peripheral nerve injury...
  15. doi request reprint Damaging effects of chronic low-dose methotrexate usage on primary bone formation in young rats and potential protective effects of folinic acid supplementary treatment
    Chiaming Fan
    Department of Orthopaedic Surgery, Women s and Children s Hospital, Adelaide, SA, Australia
    Bone 44:61-70. 2009
    ....
  16. ncbi request reprint Roles of COX-2 and iNOS in the bony repair of the injured growth plate cartilage
    G Arasapam
    Department of Physiology, University of Adelaide, Adelaide, South Australia, Australia
    J Cell Biochem 99:450-61. 2006
    ....
  17. ncbi request reprint Neurotrophins from dorsal root ganglia trigger allodynia after spinal nerve injury in rats
    X F Zhou
    Department of Human Physiology, Flinders University of South Australia, GPO Box 2100, Adelaide 5001, Australia
    Eur J Neurosci 12:100-5. 2000
    ..These studies provide the first evidence that ganglia-derived neurotrophins are a source of nociceptive stimuli for neuropathic pain after peripheral nerve injury...
  18. pmc Increased expression of HGF and c-met in rat small intestine during recovery from methotrexate-induced mucositis
    C J Xian
    Child Health Research Institute, University of Adelaide Department of Paediatrics, and Cooperative Research Centre for Tissue Growth and Repair, Australia
    Br J Cancer 82:945-52. 2000
    ..The crypt epithelial localization of HGF and c-met implies an autocrine or paracrine mechanism of HGF action...
  19. ncbi request reprint Predisposition to colonic dysplasia is unaffected by continuous administration of insulin-like growth factor-I for twenty weeks in a rat model of chronic inflammatory bowel disease
    G S Howarth
    Cooperative Research Centre for Tissue Growth and Repair, and Child Health Research Institute, North Adelaide, South Australia, Australia
    Growth Factors 18:119-33. 2000
    ..We investigated the safety of long-term IGF-I administration in a rat model of inflammatory bowel disease which predisposes to the development of dysplasia...
  20. ncbi request reprint Roles of transforming growth factor-alpha and related molecules in the nervous system
    C J Xian
    Department of Human Physiology and Centre for Neuroscience, Flinders University of South Australia, Adelaide, Australia
    Mol Neurobiol 20:157-83. 1999
    ..Although the collective roles of the EGF family (as well as those of the neuregulins) are shown to be essential for the nervous system, redundancy may exist among members of the EGF family...
  21. doi request reprint Structural and molecular analyses of bone bridge formation within the growth plate injury site and cartilage degeneration at the adjacent uninjured area
    C E Macsai
    Sansom Institute for Health Research, School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, Australia
    Bone 49:904-12. 2011
    ....
  22. ncbi request reprint Roles of neutrophil-mediated inflammatory response in the bony repair of injured growth plate cartilage in young rats
    Rosa Chung
    Women s and Children s Hospital, 72 King William Road, North Adelaide, SA 5006, Australia
    J Leukoc Biol 80:1272-80. 2006
    ....
  23. ncbi request reprint Differential effects of endogenous brain-derived neurotrophic factor on the survival of axotomized sensory neurons in dorsal root ganglia: a possible role for the p75 neurotrophin receptor
    X F Zhou
    Department of Human Physiology, Flinders University of South Australia, GPO Box 2100, Adelaide 5001, Australia
    Neuroscience 132:591-603. 2005
    ..While endogenous BDNF induced apoptosis of axotomized sensory neurons through p75NTR in vitro where more neurons expressed p75NTR, it prevented apoptosis in vivo where fewer neurons expressed p75NTR after sciatic nerve transection...
  24. ncbi request reprint Cloning of rat betacellulin and characterization of its expression in the gastrointestinal tract
    N C Kallincos
    Cooperative Research Centre for Tissue Growth and Repair, North Adelaide, Australia
    Growth Factors 18:203-13. 2000
    ..Taken together, the wide spread expression in the gut epithelium and in mucous cells in particular suggests an important and unique role for BTC in the gastrointestinal tract...
  25. ncbi request reprint Pathobiology and prevention of cancer chemotherapy-induced bone growth arrest, bone loss, and osteonecrosis
    C Fan
    Sansom Institute for Health Research, and School of Pharmacy and Medical Sciences, University of South Australia, Adelaide 5001, Australia
    Curr Mol Med 11:140-51. 2011
    ....
  26. doi request reprint Potential roles of growth factor PDGF-BB in the bony repair of injured growth plate
    Rosa Chung
    Department of Orthopaedic Surgery, Women s and Children s Hospital, North Adelaide, Australia
    Bone 44:878-85. 2009
    ..These results suggest that PDGF-BB contributes to growth plate injury repair by promoting mesenchymal progenitor cell infiltration, the chondrogenic and osteogenic responses, and remodelling of the repair tissues...
  27. doi request reprint Interaction of dietary zinc and intracellular binding protein metallothionein in postnatal bone growth
    Laura Fong
    Department of Orthopaedic Surgery, Women s and Children s Hospital, North Adelaide, SA, Australia
    Bone 44:1151-62. 2009
    ..These results indicate that interaction between dietary Zn and endogenous MT is important for maximal bone growth, and MT is particularly important in the regulation of Zn pool for bone growth during moderate Zn limitation...
  28. doi request reprint Characterisation and developmental potential of ovine bone marrow derived mesenchymal stem cells
    Rosa C McCarty
    Department of Orthopaedic Surgery, Women s and Children s Hospital, Adelaide, Australia
    J Cell Physiol 219:324-33. 2009
    ..The comprehensive characterisation of ovine MSC described herein provides important information for future translational studies involving ovine MSC...
  29. ncbi request reprint Distribution of neurturin mRNA and immunoreactivity in the peripheral tissues of adult rats
    C J Xian
    Child Health Research Institute, North Adelaide 5006, Australia
    Brain Res 835:247-58. 1999
    ....
  30. ncbi request reprint Specificity of the localization of transforming growth factor-alpha immunoreactivity in colon mucosa
    C J Xian
    Child Health Research Institute and Co operative Research Centre for Tissue Growth and Repair, North Adelaide, Australia
    J Histochem Cytochem 47:949-58. 1999
    ..In conclusion, frozen sections and antibodies raised from recombinant TGF-alpha should be used for TGF-alpha immunohistochemistry in the colon...
  31. ncbi request reprint Expression of B7 costimulatory molecules by cells infiltrating the colon in experimental colitis induced by oral dextran sulfate sodium in the mouse
    R H Grose
    Cooperative Research Centre for Tissue Growth and Repair, Child Health Research Institute, North Adelaide, South Australia
    J Gastroenterol Hepatol 16:1228-34. 2001
    ..These results suggest an intervention strategy based on the blockade of the B7-costimulatory axis could find application in the treatment of inflammatory bowel disease...
  32. ncbi request reprint Damage and recovery of the bone marrow microenvironment induced by cancer chemotherapy - potential regulatory role of chemokine CXCL12/receptor CXCR4 signalling
    K R Georgiou
    Discipline of Physiology, University of Adelaide, Adelaide 5005, Australia
    Curr Mol Med 10:440-53. 2010
    ..This review also discusses molecular targets that are being used clinically or are currently under investigation for preserving the bone marrow microenvironment during or enhancing recovery after chemotherapy...
  33. doi request reprint Roles of Wnt signalling in bone growth, remodelling, skeletal disorders and fracture repair
    Carmen E Macsai
    Department of Orthopaedic Surgery, Women s and Children s Hospital, North Adelaide, South Australia, Australia
    J Cell Physiol 215:578-87. 2008
    ..Furthermore, Wnt signalling is activated during bone fracture repair and plays a crucial role in regulating bone regeneration...
  34. ncbi request reprint Expression of bone morphogenic proteins and receptors at the injured growth plate cartilage in young rats
    Thai Q Ngo
    Department of Orthopaedic Surgery, Women s and Children s Hospital, 72 King William Road, North Adelaide, SA 5006 Australia
    J Histochem Cytochem 54:945-54. 2006
    ....
  35. ncbi request reprint Expression of proinflammatory cytokines and growth factors at the injured growth plate cartilage in young rats
    Fiona H Zhou
    Department of Orthopaedic Surgery, and University of Adelaide Department of Pediatrics, Women s and Children s Hospital, North Adelaide, South Australia, Australia
    Bone 35:1307-15. 2004
    ..The lack of up-regulation of Col-2a and Sox9 refutes the involvement of endochondral ossification but confirms a direct bone formation response during bone bridge formation at the injured growth plate...
  36. doi request reprint Treating skeletal pain: limitations of conventional anti-inflammatory drugs, and anti-neurotrophic factor as a possible alternative
    Cory J Xian
    Sansom Institute of Health Research, School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, SA, Australia
    Nat Clin Pract Rheumatol 5:92-8. 2009
    ..Nerve growth factor inhibitors, therefore, might be an effective alternative modality for post-traumatic and post-surgical analgesia, without impairing bone healing...
  37. doi request reprint Preconditioning selective ventral root injury promotes plasticity of ascending sensory neurons in the injured spinal cord of adult rats--possible roles of brain-derived neurotrophic factor, TrkB and p75 neurotrophin receptor
    Fang Li
    Department of Human Physiology and Centre for Neuroscience, Flinders University of South Australia, Adelaide, SA 5001, Australia
    Eur J Neurosci 30:1280-96. 2009
    ....
  38. ncbi request reprint Effect of lumbar 5 ventral root transection on pain behaviors: a novel rat model for neuropathic pain without axotomy of primary sensory neurons
    Li Li
    Department of Human Physiology and Center for Neuroscience, Flinders University of South Australia, Adelaide, 5001, Australia
    Exp Neurol 175:23-34. 2002
    ..The L5 VRT model manifests the complex regional pain syndrome in some human patients, and it may provide an additional dimension to dissect out the mechanisms underlying neuropathic pain...
  39. ncbi request reprint Pre-treatment with insulin-like growth factor-I partially ameliorates 5-fluorouracil-induced intestinal mucositis in rats
    Johanna C Cool
    Cooperative Research Centre for Tissue Growth and Repair, Australia
    Growth Horm IGF Res 15:72-82. 2005
    ..We conclude that IGF-I pre-treatment only partially attenuates features of intestinal mucositis when assessed 48 h after 5-FU chemotherapy...
  40. ncbi request reprint Upregulation of brain-derived neurotrophic factor in the sensory pathway by selective motor nerve injury in adult rats
    Li Li
    Department of Human Physiology and Centre for Neuroscience, Flinders University of South Australia, GPO Box 2100, Adelaide 5001, Australia
    Neurotox Res 9:269-83. 2006
    ..These results suggest that increased BDNF expression in intact primary sensory neurons and spinal cord may be an important factor in the induction of neuropathic pain without axotomy of sensory neurons...
  41. ncbi request reprint Lumbar 5 ventral root transection-induced upregulation of nerve growth factor in sensory neurons and their target tissues: a mechanism in neuropathic pain
    Li Li
    Department of Human Physiology and Center for Neuroscience, Flinders University of South Australia, GPO Box 2100, Adelaide 5001, Australia
    Mol Cell Neurosci 23:232-50. 2003
    ..These findings suggest that NGF is an important pain mediator in the generation of mechanical sensitivity induced by L5 VRT...