C V Wynter
Affiliation: University of Queensland
- The dialectics of cancer: A theory of the initiation and development of cancer through errors in RNAiCoral V A Wynter
Queensland Institute of Medical Research, 300 Herston Road, Herston, Queensland 4029, Australia
Med Hypotheses 66:612-35. 2006..This leads to dedifferentiation of the tissue, a resculpting of the histone code, chromosomal rearrangements, along a number of specific pathways, the gain of immortality and the dissemination of a metastatic cancer...
- Angiogenic factor VEGF is decreased in human colorectal neoplasms showing DNA microsatellite instabilityC V Wynter
Department of Surgery, Greenslopes Private Hospital, University of Queensland, Brisbane, Australia
J Pathol 189:319-25. 1999..The low frequency of VEGF expression amongst MSI-H cancers may partially explain why these cancers are less aggressive, with a better overall prognosis...
- Methylation patterns define two types of hyperplastic polyp associated with colorectal cancerC V A Wynter
Conjoint Gastroenterology Laboratory, Royal Brisbane and Women s Hospital Research Foundation, Bancroft Centre, Queensland, Australia
Gut 53:573-80. 2004..The aim of this study was to identify morphological and molecular features that may characterise subtypes of HP with potential for neoplastic progression...
- DNA methylation patterns in adenomas from FAP, multiple adenoma and sporadic colorectal carcinoma patientsCoral V A Wynter
Conjoint Gastroenterology Laboratory, Clinical Research Centre, Queensland Institute of Medical Research, Brisbane, Queensland Australia
Int J Cancer 118:907-15. 2006..Genetic profiling of adenomas supports the concept that adenomas belonging to familial syndromes pursue a different pathway to tumorigenesis than their sporadic counterpar/ts from their earliest formation...
- Morphological and molecular heterogeneity within nonmicrosatellite instability-high colorectal cancerVicki L J Whitehall
Conjoint Gastroenterology Laboratory, Clinical Research Centre, Royal Brisbane Hospital Research Foundation, Queensland 4029, Australia
Cancer Res 62:6011-4. 2002..004) and lower frequency of hMLH1 methylation (P < 0.001) in the latter. These data demonstrate that the separation of CRC into two nonoverlapping groups (MSI-H versus MSS/MSI-L) is a misleading oversimplification...
- Role of inherited defects of MYH in the development of sporadic colorectal cancerTakeshi Kambara
Conjoint Gastroenterology Laboratory, Royal Brisbane and Women s Hospital Research Foundation and Queensland Institute of Medical Research, Brisbane, Australia
Genes Chromosomes Cancer 40:1-9. 2004..02). These results suggest that single germ-line variants of MYH may influence genetic pathways in CRC...