Research Topics
Genomes and Genes | Huiling WuSummaryAffiliation: University of Sydney Country: Australia Publications
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Detail Information
Publications
DNA vaccination against specific pathogenic TCRs reduces proteinuria in active Heymann nephritis by inducing specific autoantibodiesHuiling Wu
Centre for Kidney Research, The Children s Hospital at Westmead, Sydney, Australia
J Immunol 171:4824-9. 2003..In this study, we have shown that treatment with TCR-based DV, targeting previously identified pathogenic Vbeta families, protects against HN, and that the mechanism may involve the production of specific anti-TCR Abs...
IL-18 contributes to renal damage after ischemia-reperfusionHuiling Wu
Collaborative Transplant Research Group, Renal Medicine, Royal Prince Alfred Hospital and Bosch Institute, Faculty of Medicine, University of Sydney, Sydney, Australia
J Am Soc Nephrol 19:2331-41. 2008..In conclusion, IL-18, derived primarily from cells of bone marrow origin, contributes to the renal damage observed during IRI. IL-18-binding protein may have potential as a renoprotective therapy...- DNA vaccination with naked DNA encoding MCP-1 and RANTES protects against renal injury in adriamycin nephropathyHuiling Wu
Centre for Kidney Research, The Children s Hospital at Westmead, Westmead, New South Wales, Australia
Kidney Int 67:2178-86. 2005..In this study, we tested the effect of DNA vaccination encoding the C-C chemokines MCP-1 and RANTES in a rat model of adriamycin nephropathy... - TLR4 activation mediates kidney ischemia/reperfusion injuryHuiling Wu
Collaborative Transplant Research Group, Royal Prince Alfred Hospital and Bosch Institute, Faculty of Medicine, University of Sydney, Sydney, New South Wales, Australia
J Clin Invest 117:2847-59. 2007.... - Depletion of gammadelta T cells exacerbates murine adriamycin nephropathyHuiling Wu
Centre for Kidney Research, The Children s Hospital at Westmead, Locked Bag 4001, Westmead NSW 2145, Australia
J Am Soc Nephrol 18:1180-9. 2007..These studies indicate the involvement of the gammadelta T cell in innate recognition and regulation of inflammation in AN... - HMGB1 contributes to kidney ischemia reperfusion injuryHuiling Wu
Collaborative Transplant Research Group, Royal Prince Alfred Hospital, Sydney, Australia
J Am Soc Nephrol 21:1878-90. 2010..Administration of a neutralizing antibody to HMGB1 either before or soon after ischemia-reperfusion affords significant protection, suggesting therapeutic potential for acute kidney injury... - CD8+ regulatory T cells induced by T cell vaccination protect against autoimmune nephritisYuan Min Wang
Centre for Kidney Research, Children s Hospital at Westmead, Westmead, Sydney, NSW 2145, Australia
J Am Soc Nephrol 23:1058-67. 2012..Taken together, these results suggest that TCV protects against autoimmune kidney disease by targeting Qa-1-expressing autoreactive CD4+ cells... - DNA vaccination with CCL2 DNA modified by the addition of an adjuvant epitope protects against "nonimmune" toxic renal injuryGuoping Zheng
Centre for Transplantation and Renal Research, University of Sydney at Westmead Millenium Institute, Westmead, Sydney, NSW 2145 Australia
J Am Soc Nephrol 17:465-74. 2006.... - Daedalic DNA vaccination against self antigens as a treatment for chronic kidney diseaseYuan Min Wang
Centre for Kidney Research, Children s Hospital at Westmead Sydney, NSW, Australia
Int J Clin Exp Pathol 6:326-33. 2013..Finally, we discuss the specific application of DNA vaccination for preventing and treating CKD... - Absence of MyD88 signaling induces donor-specific kidney allograft toleranceHuiling Wu
Transplant Research Group, University of Sydney, Sydney, NSW 2006, Australia
J Am Soc Nephrol 23:1701-16. 2012..This study provides evidence that targeting innate immunity may be a clinically relevant strategy to facilitate transplantation tolerance... 
CCL2 DNA vaccine to treat renal diseaseDebbie Watson
Centre for Kidney Research, Children s Hospital at Westmead, Westmead, New South Wales, Australia
Int J Biochem Cell Biol 41:729-32. 2009..The strategies outlined here demonstrate a model for developing potent vaccines against highly restricted self targets...- DNA vaccine encoding CD40 targeted to dendritic cells in situ prevents the development of Heymann nephritis in ratsYa Wang
Centre for Transplantation and Renal Research, University of Sydney at Westmead Millennium Institute, Westmead, Sydney, New South Wales, Australia
Kidney Int 83:223-32. 2013..Thus, CD40 DNA vaccination targeted to dendritic cells limits the development of Heymann nephritis... - Requirement of MyD88 for macrophage-mediated islet xenograft rejection after adoptive transferShounan Yi
Center for Transplant and Renal Research, Westmead Millennium Institute, University of Sydney at Westmead Hospital, Westmead, Australia
Transplantation 83:615-23. 2007..Porcine antigen primed and CD4+ T-cell activated macrophages are able to migrate to and destroy porcine xenografts. However, the specific signaling mechanisms involved remain to be identified... - Foxp3-transduced polyclonal regulatory T cells protect against chronic renal injury from adriamycinYuan Min Wang
Centre for Kidney Research, Children's Hospital at Westmead, and Centre for Transplantation and Renal Research, University of Sydney at Westmead Millennium Institute, New South Wales 2145, Sydney, Australia
J Am Soc Nephrol 17:697-706. 2006..01). It is concluded that Foxp3-transduced Treg cells may have a therapeutic role in protecting against immune injury and disease progression in chronic proteinuric renal disease... - Macrophages and kidney transplantationSteven J Chadban
Collaborative Transplantation Laboratory, Sydney Medical School, University of Sydney, New South Wales, Australia
Semin Nephrol 30:278-89. 2010..A deeper understanding of how macrophages accumulate within the kidney and of what factors control their differentiation and function may identify novel therapeutic targets in transplantation... - Sirolimus reduces vasculopathy but exacerbates proteinuria in association with inhibition of VEGF and VEGFR in a rat kidney model of chronic allograft dysfunctionHung T Ko
Collaborative Transplantation Laboratory, Sydney Medical School and Department of Renal Medicine, Royal Prince Alfred Hospital, Sydney, Australia
Nephrol Dial Transplant 28:327-36. 2013..We therefore explored the impact of sirolimus on the development of chronic allograft dysfunction (CAD) in the rat, with a focus on VEGF biology... - Toll-like receptor 4 engagement contributes to expression of NKG2D ligands by renal tubular epithelial cellsGang Eric Chen
The University of Sydney, Sydney, Australia
Nephrol Dial Transplant 26:3873-81. 2011..Whether engagement of TLR4 on kidney cells results in additional pro-inflammatory modifications of the renal microenvironment remains to be determined... - Regulatory gamma delta T cells in Heymann nephritis express an invariant Vgamma6/Vdelta1 with a canonical CDR3 sequenceHuiling Wu
Centre for Kidney Research, The Children s Hospital at Westmead, Westmead, Australia
Eur J Immunol 34:2322-30. 2004.... - Glomerular T cells are of restricted clonality and express multiple CDR3 motifs across different Vbeta T-cell receptor families in experimental autoimmune glomerulonephritisGiles Walters
Centre for Kidney Research, The Children's Hospital, Westmead, Australia
Nephron Exp Nephrol 98:e71-81. 2004..Our results show that glomerular T cells are of restricted clonality and suggest a role for antigen-specific effector T cells in the pathogenesis of EAG... - The role of macrophages in allograft rejectionKate R Wyburn
Department of Transplantation, Royal Prince Alfred Hospital and University of Sydney, Sydney, Australia
Transplantation 80:1641-7. 2005..Therapeutic attention to macrophages, in addition to T lymphocytes, may lead to improved outcomes in organ transplantation... - Dentritic cell derived IL-18 production is inhibited by rapamycin and sanglifehrin A, but not cyclosporine AHungta Ko
Department of Pathology, University of Sydney, NSW 2006, Australia
Transpl Immunol 20:99-105. 2008..In conclusion, Rapa and SFA, but not CsA, block IL-18 production and this novel Rapa blockade effect on IL-18 may contribute to the ability of Rapa to inhibit chronic allograft nephropathy and restenosis... - Interleukin-18 binding protein therapy is protective in adriamycin nephropathyKate R Wyburn
Collaborative Transplant Research Group, Royal Prince Alfred Hospital, University of Sydney, Sydney, New South Wales, Australia
Am J Physiol Renal Physiol 304:F68-76. 2013..The protective effect of IL-18BP therapy illustrates the importance of immune mediators in chronic proteinuric kidney disease and highlights the potential of IL-18BP therapy... - Macrophage-derived interleukin-18 in experimental renal allograft rejectionKate Wyburn
Transplantation Laboratory, Royal Prince Alfred Hospital, University of Sydney, NSW 2006, Australia
Nephrol Dial Transplant 20:699-706. 2005..Interleukin 18 (IL-18) is primarily a macrophage-derived, pro-inflammatory cytokine. As macrophages can act as effector cells in acute rejection, we examined the role of IL-18 in a rat model of acute renal allograft rejection...