Huiling Wu

Summary

Affiliation: University of Sydney
Country: Australia

Publications

  1. ncbi request reprint DNA vaccination against specific pathogenic TCRs reduces proteinuria in active Heymann nephritis by inducing specific autoantibodies
    Huiling Wu
    Centre for Kidney Research, The Children s Hospital at Westmead, Sydney, Australia
    J Immunol 171:4824-9. 2003
  2. pmc IL-18 contributes to renal damage after ischemia-reperfusion
    Huiling Wu
    Collaborative Transplant Research Group, Renal Medicine, Royal Prince Alfred Hospital and Bosch Institute, Faculty of Medicine, University of Sydney, Sydney, Australia
    J Am Soc Nephrol 19:2331-41. 2008
  3. pmc TLR4 activation mediates kidney ischemia/reperfusion injury
    Huiling Wu
    Collaborative Transplant Research Group, Royal Prince Alfred Hospital and Bosch Institute, Faculty of Medicine, University of Sydney, Sydney, New South Wales, Australia
    J Clin Invest 117:2847-59. 2007
  4. ncbi request reprint DNA vaccination with naked DNA encoding MCP-1 and RANTES protects against renal injury in adriamycin nephropathy
    Huiling Wu
    Centre for Kidney Research, The Children s Hospital at Westmead, Westmead, New South Wales, Australia
    Kidney Int 67:2178-86. 2005
  5. ncbi request reprint Depletion of gammadelta T cells exacerbates murine adriamycin nephropathy
    Huiling Wu
    Centre for Kidney Research, The Children s Hospital at Westmead, Locked Bag 4001, Westmead NSW 2145, Australia
    J Am Soc Nephrol 18:1180-9. 2007
  6. ncbi request reprint Sirolimus reduces vasculopathy but exacerbates proteinuria in association with inhibition of VEGF and VEGFR in a rat kidney model of chronic allograft dysfunction
    Hung T Ko
    Collaborative Transplantation Laboratory, Sydney Medical School and Department of Renal Medicine, Royal Prince Alfred Hospital, Sydney, Australia
    Nephrol Dial Transplant 28:327-36. 2013
  7. pmc Daedalic DNA vaccination against self antigens as a treatment for chronic kidney disease
    Yuan Min Wang
    Centre for Kidney Research, Children s Hospital at Westmead Sydney, NSW, Australia
    Int J Clin Exp Pathol 6:326-33. 2013
  8. ncbi request reprint DNA vaccination with CCL2 DNA modified by the addition of an adjuvant epitope protects against "nonimmune" toxic renal injury
    Guoping Zheng
    Centre for Transplantation and Renal Research, University of Sydney at Westmead Millenium Institute, Westmead, Sydney, NSW 2145 Australia
    J Am Soc Nephrol 17:465-74. 2006
  9. doi request reprint DNA vaccine encoding CD40 targeted to dendritic cells in situ prevents the development of Heymann nephritis in rats
    Ya Wang
    Centre for Transplantation and Renal Research, University of Sydney at Westmead Millennium Institute, Westmead, Sydney, New South Wales, Australia
    Kidney Int 83:223-32. 2013
  10. pmc HMGB1 contributes to kidney ischemia reperfusion injury
    Huiling Wu
    Collaborative Transplant Research Group, Royal Prince Alfred Hospital, Sydney, Australia
    J Am Soc Nephrol 21:1878-90. 2010

Detail Information

Publications27

  1. ncbi request reprint DNA vaccination against specific pathogenic TCRs reduces proteinuria in active Heymann nephritis by inducing specific autoantibodies
    Huiling Wu
    Centre for Kidney Research, The Children s Hospital at Westmead, Sydney, Australia
    J Immunol 171:4824-9. 2003
    ..In this study, we have shown that treatment with TCR-based DV, targeting previously identified pathogenic Vbeta families, protects against HN, and that the mechanism may involve the production of specific anti-TCR Abs...
  2. pmc IL-18 contributes to renal damage after ischemia-reperfusion
    Huiling Wu
    Collaborative Transplant Research Group, Renal Medicine, Royal Prince Alfred Hospital and Bosch Institute, Faculty of Medicine, University of Sydney, Sydney, Australia
    J Am Soc Nephrol 19:2331-41. 2008
    ..In conclusion, IL-18, derived primarily from cells of bone marrow origin, contributes to the renal damage observed during IRI. IL-18-binding protein may have potential as a renoprotective therapy...
  3. pmc TLR4 activation mediates kidney ischemia/reperfusion injury
    Huiling Wu
    Collaborative Transplant Research Group, Royal Prince Alfred Hospital and Bosch Institute, Faculty of Medicine, University of Sydney, Sydney, New South Wales, Australia
    J Clin Invest 117:2847-59. 2007
    ....
  4. ncbi request reprint DNA vaccination with naked DNA encoding MCP-1 and RANTES protects against renal injury in adriamycin nephropathy
    Huiling Wu
    Centre for Kidney Research, The Children s Hospital at Westmead, Westmead, New South Wales, Australia
    Kidney Int 67:2178-86. 2005
    ..In this study, we tested the effect of DNA vaccination encoding the C-C chemokines MCP-1 and RANTES in a rat model of adriamycin nephropathy...
  5. ncbi request reprint Depletion of gammadelta T cells exacerbates murine adriamycin nephropathy
    Huiling Wu
    Centre for Kidney Research, The Children s Hospital at Westmead, Locked Bag 4001, Westmead NSW 2145, Australia
    J Am Soc Nephrol 18:1180-9. 2007
    ..These studies indicate the involvement of the gammadelta T cell in innate recognition and regulation of inflammation in AN...
  6. ncbi request reprint Sirolimus reduces vasculopathy but exacerbates proteinuria in association with inhibition of VEGF and VEGFR in a rat kidney model of chronic allograft dysfunction
    Hung T Ko
    Collaborative Transplantation Laboratory, Sydney Medical School and Department of Renal Medicine, Royal Prince Alfred Hospital, Sydney, Australia
    Nephrol Dial Transplant 28:327-36. 2013
    ..We therefore explored the impact of sirolimus on the development of chronic allograft dysfunction (CAD) in the rat, with a focus on VEGF biology...
  7. pmc Daedalic DNA vaccination against self antigens as a treatment for chronic kidney disease
    Yuan Min Wang
    Centre for Kidney Research, Children s Hospital at Westmead Sydney, NSW, Australia
    Int J Clin Exp Pathol 6:326-33. 2013
    ..Finally, we discuss the specific application of DNA vaccination for preventing and treating CKD...
  8. ncbi request reprint DNA vaccination with CCL2 DNA modified by the addition of an adjuvant epitope protects against "nonimmune" toxic renal injury
    Guoping Zheng
    Centre for Transplantation and Renal Research, University of Sydney at Westmead Millenium Institute, Westmead, Sydney, NSW 2145 Australia
    J Am Soc Nephrol 17:465-74. 2006
    ....
  9. doi request reprint DNA vaccine encoding CD40 targeted to dendritic cells in situ prevents the development of Heymann nephritis in rats
    Ya Wang
    Centre for Transplantation and Renal Research, University of Sydney at Westmead Millennium Institute, Westmead, Sydney, New South Wales, Australia
    Kidney Int 83:223-32. 2013
    ..Thus, CD40 DNA vaccination targeted to dendritic cells limits the development of Heymann nephritis...
  10. pmc HMGB1 contributes to kidney ischemia reperfusion injury
    Huiling Wu
    Collaborative Transplant Research Group, Royal Prince Alfred Hospital, Sydney, Australia
    J Am Soc Nephrol 21:1878-90. 2010
    ..Administration of a neutralizing antibody to HMGB1 either before or soon after ischemia-reperfusion affords significant protection, suggesting therapeutic potential for acute kidney injury...
  11. pmc CD8+ regulatory T cells induced by T cell vaccination protect against autoimmune nephritis
    Yuan Min Wang
    Centre for Kidney Research, Children s Hospital at Westmead, Westmead, Sydney, NSW 2145, Australia
    J Am Soc Nephrol 23:1058-67. 2012
    ..Taken together, these results suggest that TCV protects against autoimmune kidney disease by targeting Qa-1-expressing autoreactive CD4+ cells...
  12. pmc Absence of MyD88 signaling induces donor-specific kidney allograft tolerance
    Huiling Wu
    Transplant Research Group, University of Sydney, Sydney, NSW 2006, Australia
    J Am Soc Nephrol 23:1701-16. 2012
    ..This study provides evidence that targeting innate immunity may be a clinically relevant strategy to facilitate transplantation tolerance...
  13. doi request reprint CCL2 DNA vaccine to treat renal disease
    Debbie Watson
    Centre for Kidney Research, Children s Hospital at Westmead, Westmead, New South Wales, Australia
    Int J Biochem Cell Biol 41:729-32. 2009
    ..The strategies outlined here demonstrate a model for developing potent vaccines against highly restricted self targets...
  14. ncbi request reprint Requirement of MyD88 for macrophage-mediated islet xenograft rejection after adoptive transfer
    Shounan Yi
    Center for Transplant and Renal Research, Westmead Millennium Institute, University of Sydney at Westmead Hospital, Westmead, Australia
    Transplantation 83:615-23. 2007
    ..Porcine antigen primed and CD4+ T-cell activated macrophages are able to migrate to and destroy porcine xenografts. However, the specific signaling mechanisms involved remain to be identified...
  15. ncbi request reprint Foxp3-transduced polyclonal regulatory T cells protect against chronic renal injury from adriamycin
    Yuan Min Wang
    Centre for Kidney Research, Children s Hospital at Westmead, and Centre for Transplantation and Renal Research, University of Sydney at Westmead Millennium Institute, New South Wales 2145, Sydney, Australia
    J Am Soc Nephrol 17:697-706. 2006
    ..01). It is concluded that Foxp3-transduced Treg cells may have a therapeutic role in protecting against immune injury and disease progression in chronic proteinuric renal disease...
  16. doi request reprint Macrophages and kidney transplantation
    Steven J Chadban
    Collaborative Transplantation Laboratory, Sydney Medical School, University of Sydney, New South Wales, Australia
    Semin Nephrol 30:278-89. 2010
    ..A deeper understanding of how macrophages accumulate within the kidney and of what factors control their differentiation and function may identify novel therapeutic targets in transplantation...
  17. pmc TLR4 activation promotes podocyte injury and interstitial fibrosis in diabetic nephropathy
    Jin Ma
    Sydney Medical School, The University of Sydney, Sydney, New South Wales, Australia
    PLoS ONE 9:e97985. 2014
    ..Our data indicate that TLR4 activation may promote inflammation, podocyte and tubular epithelial cell injury and interstitial fibrosis, suggesting TLR4 is a potential therapeutic target for diabetic nephropathy. ..
  18. doi request reprint The role of Toll-like receptor proteins (TLR) 2 and 4 in mediating inflammation in proximal tubules
    Harshini Mudaliar
    Renal Research Group, Kolling Institute of Medical Research, University of Sydney, Royal North Shore Hospital, St Leonards, New South Wales, Australia
    Am J Physiol Renal Physiol 305:F143-54. 2013
    ..These results collectively suggest that TLR2 is likely to be the predominant long-term mediator of NF-κB activation in transducing inflammation in diabetic nephropathy. ..
  19. doi request reprint Interleukin-18 binding protein therapy is protective in adriamycin nephropathy
    Kate R Wyburn
    Collaborative Transplant Research Group, Royal Prince Alfred Hospital, University of Sydney, Sydney, New South Wales, Australia
    Am J Physiol Renal Physiol 304:F68-76. 2013
    ..The protective effect of IL-18BP therapy illustrates the importance of immune mediators in chronic proteinuric kidney disease and highlights the potential of IL-18BP therapy...
  20. doi request reprint Toll-like receptor 4 engagement contributes to expression of NKG2D ligands by renal tubular epithelial cells
    Gang Eric Chen
    The University of Sydney, Sydney, Australia
    Nephrol Dial Transplant 26:3873-81. 2011
    ..Whether engagement of TLR4 on kidney cells results in additional pro-inflammatory modifications of the renal microenvironment remains to be determined...
  21. ncbi request reprint Glomerular T cells are of restricted clonality and express multiple CDR3 motifs across different Vbeta T-cell receptor families in experimental autoimmune glomerulonephritis
    Giles Walters
    Centre for Kidney Research, The Children s Hospital, Westmead, Australia
    Nephron Exp Nephrol 98:e71-81. 2004
    ..Our results show that glomerular T cells are of restricted clonality and suggest a role for antigen-specific effector T cells in the pathogenesis of EAG...
  22. ncbi request reprint Regulatory gamma delta T cells in Heymann nephritis express an invariant Vgamma6/Vdelta1 with a canonical CDR3 sequence
    Huiling Wu
    Centre for Kidney Research, The Children s Hospital at Westmead, Westmead, Australia
    Eur J Immunol 34:2322-30. 2004
    ....
  23. doi request reprint Dentritic cell derived IL-18 production is inhibited by rapamycin and sanglifehrin A, but not cyclosporine A
    Hungta Ko
    Department of Pathology, University of Sydney, NSW 2006, Australia
    Transpl Immunol 20:99-105. 2008
    ..In conclusion, Rapa and SFA, but not CsA, block IL-18 production and this novel Rapa blockade effect on IL-18 may contribute to the ability of Rapa to inhibit chronic allograft nephropathy and restenosis...
  24. ncbi request reprint The role of macrophages in allograft rejection
    Kate R Wyburn
    Department of Transplantation, Royal Prince Alfred Hospital and University of Sydney, Sydney, Australia
    Transplantation 80:1641-7. 2005
    ..Therapeutic attention to macrophages, in addition to T lymphocytes, may lead to improved outcomes in organ transplantation...
  25. ncbi request reprint Preconditioning with recombinant high-mobility group box 1 protein protects the kidney against ischemia-reperfusion injury in mice
    Huiling Wu
    1 Renal Medicine, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia 2 Collaborative Transplant Research Group, Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia
    Kidney Int 85:824-32. 2014
    ..Thus, preconditioning with rHMGB1 affords significant protection from TLR4-dependent kidney ischemia-reperfusion injury, indicating therapeutic potential. ..
  26. ncbi request reprint Macrophage-derived interleukin-18 in experimental renal allograft rejection
    Kate Wyburn
    Transplantation Laboratory, Royal Prince Alfred Hospital, University of Sydney, NSW 2006, Australia
    Nephrol Dial Transplant 20:699-706. 2005
    ..Interleukin 18 (IL-18) is primarily a macrophage-derived, pro-inflammatory cytokine. As macrophages can act as effector cells in acute rejection, we examined the role of IL-18 in a rat model of acute renal allograft rejection...
  27. doi request reprint Roles of Toll-like receptors in transplantation
    Huiling Wu
    Renal Medicine, Royal Prince Alfred Hospital and Sydney Medical School, The University of Sydney, Sydney, New South Wales, Australia
    Curr Opin Organ Transplant 19:1-7. 2014
    ..Here, we will review recent evidence examining the role of TLRs in determining the fate of the transplanted organ...