Stephen J Wood

Summary

Affiliation: University of Melbourne
Country: Australia

Publications

  1. ncbi Medial temporal lobe glutathione concentration in first episode psychosis: a 1H-MRS investigation
    Stephen J Wood
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Australia
    Neurobiol Dis 33:354-7. 2009
  2. ncbi Cognitive decline following psychosis onset: data from the PACE clinic
    Stephen J Wood
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne, c o National Neuroscience Facility, 161 Barry Street, Carlton South, VIC 3053 Australia
    Br J Psychiatry Suppl 51:s52-7. 2007
  3. ncbi Fractionation of verbal memory impairment in schizophrenia and schizophreniform psychosis
    Stephen J Wood
    Melbourne Neuropsychiatry Centre, c National Neuroscience Facility, Carlton, Melbourne, Victoria, Australia
    Aust N Z J Psychiatry 41:732-9. 2007
  4. ncbi Neuroprotective effects of ethyl-eicosapentaenoic acid in first episode psychosis: a longitudinal T2 relaxometry pilot study
    Stephen J Wood
    Melbourne Neuropsychiatry Centre, University of Melbourne, Australia
    Psychiatry Res 182:180-2. 2010
  5. ncbi Progressive changes in the development toward schizophrenia: studies in subjects at increased symptomatic risk
    Stephen J Wood
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne, Australia
    Schizophr Bull 34:322-9. 2008
  6. ncbi Hippocampal pathology in individuals at ultra-high risk for psychosis: a multi-modal magnetic resonance study
    Stephen J Wood
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Parkville, Vic, Australia
    Neuroimage 52:62-8. 2010
  7. ncbi Hippocampal and anterior cingulate morphology in subjects at ultra-high-risk for psychosis: the role of family history of psychotic illness
    Stephen J Wood
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne, National Neuroscience Facility, 161 Barry Street, Carlton South VIC 3053, Australia
    Schizophr Res 75:295-301. 2005
  8. ncbi Brain changes during the onset of schizophrenia: implications for neurodevelopmental theories
    Stephen J Wood
    Melbourne Neuropsychiatry Centre, University of Melbourne and Melbourne Health, Melbourne, Vic
    Med J Aust 190:S10-3. 2009
  9. ncbi Prediction of functional outcome 18 months after a first psychotic episode: a proton magnetic resonance spectroscopy study
    Stephen J Wood
    Melbourne Neuropsychiatry Centre, University of Melbourne, c o National Neuroscience Facility, 161 Barry Street, Carlton, Melbourne, Victoria 3053, Australia
    Arch Gen Psychiatry 63:969-76. 2006
  10. ncbi Neurobiology of schizophrenia spectrum disorders: the role of oxidative stress
    Stephen J Wood
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Melbourne, Australia
    Ann Acad Med Singapore 38:396-6. 2009

Detail Information

Publications105 found, 100 shown here

  1. ncbi Medial temporal lobe glutathione concentration in first episode psychosis: a 1H-MRS investigation
    Stephen J Wood
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Australia
    Neurobiol Dis 33:354-7. 2009
    ..This study provides further evidence of significant perturbations in brain GSH in first episode psychosis, and supports a broader involvement of GSH in the pathophysiology of schizophrenia...
  2. ncbi Cognitive decline following psychosis onset: data from the PACE clinic
    Stephen J Wood
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne, c o National Neuroscience Facility, 161 Barry Street, Carlton South, VIC 3053 Australia
    Br J Psychiatry Suppl 51:s52-7. 2007
    ..The origin of cognitive impairments in psychotic disorders is still unclear. Although some deficits are apparent prior to the onset of frank illness, it is unknown if they progress...
  3. ncbi Fractionation of verbal memory impairment in schizophrenia and schizophreniform psychosis
    Stephen J Wood
    Melbourne Neuropsychiatry Centre, c National Neuroscience Facility, Carlton, Melbourne, Victoria, Australia
    Aust N Z J Psychiatry 41:732-9. 2007
    ..The impact of antipsychotic medications is also unclear. The purpose of the present paper was to investigate verbal memory performance in established schizophrenia (SZ) and first-episode schizophreniform psychosis (FE)...
  4. ncbi Neuroprotective effects of ethyl-eicosapentaenoic acid in first episode psychosis: a longitudinal T2 relaxometry pilot study
    Stephen J Wood
    Melbourne Neuropsychiatry Centre, University of Melbourne, Australia
    Psychiatry Res 182:180-2. 2010
    ..There was an increase in T(2) in the placebo group but not in the E-EPA group, suggesting a neuroprotective effect of E-EPA treatment. In addition, the smaller the increase in T(2), the greater the improvement in negative symptoms...
  5. ncbi Progressive changes in the development toward schizophrenia: studies in subjects at increased symptomatic risk
    Stephen J Wood
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne, Australia
    Schizophr Bull 34:322-9. 2008
    ..Active changes during transition to illness may present the potential to intervene and ameliorate these changes with potential benefit clinically...
  6. ncbi Hippocampal pathology in individuals at ultra-high risk for psychosis: a multi-modal magnetic resonance study
    Stephen J Wood
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Parkville, Vic, Australia
    Neuroimage 52:62-8. 2010
    ..However, standard measures of neuroanatomical disturbance do not appear to be predictive of later transition, and instead are likely to be non-specific and common in cases that later develop a non-psychotic disorder...
  7. ncbi Hippocampal and anterior cingulate morphology in subjects at ultra-high-risk for psychosis: the role of family history of psychotic illness
    Stephen J Wood
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne, National Neuroscience Facility, 161 Barry Street, Carlton South VIC 3053, Australia
    Schizophr Res 75:295-301. 2005
    ..Some appear to predate the illness and may be genetic in origin, while others are associated with the onset of the disorder...
  8. ncbi Brain changes during the onset of schizophrenia: implications for neurodevelopmental theories
    Stephen J Wood
    Melbourne Neuropsychiatry Centre, University of Melbourne and Melbourne Health, Melbourne, Vic
    Med J Aust 190:S10-3. 2009
    ..Although the cause of these changes is unclear, they challenge the conventional neurodevelopmental model of schizophrenia...
  9. ncbi Prediction of functional outcome 18 months after a first psychotic episode: a proton magnetic resonance spectroscopy study
    Stephen J Wood
    Melbourne Neuropsychiatry Centre, University of Melbourne, c o National Neuroscience Facility, 161 Barry Street, Carlton, Melbourne, Victoria 3053, Australia
    Arch Gen Psychiatry 63:969-76. 2006
    ..These studies have generally been negative, perhaps because gray and white matter volumes inaccurately assess the underlying dysfunction that might be predictive of outcome...
  10. ncbi Neurobiology of schizophrenia spectrum disorders: the role of oxidative stress
    Stephen J Wood
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Melbourne, Australia
    Ann Acad Med Singapore 38:396-6. 2009
    ..We argue that a better understanding of the mechanisms and pathways underlying oxidative stress will assist in developing the therapeutic potential of this area...
  11. ncbi A 1H-MRS investigation of the medial temporal lobe in antipsychotic-naïve and early-treated first episode psychosis
    Stephen J Wood
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Australia
    Schizophr Res 102:163-70. 2008
    ..Seemingly illness-related Cr/PCr elevations were also specific to the diagnosis of schizophrenia-spectrum disorder and seem worthy of future study...
  12. ncbi Progressive gray matter reduction of the superior temporal gyrus during transition to psychosis
    Tsutomu Takahashi
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Australia
    Arch Gen Psychiatry 66:366-76. 2009
    ..It is unknown whether these progressive processes predate the onset of psychosis...
  13. ncbi Prevalence of large cavum septi pellucidi in ultra high-risk individuals and patients with psychotic disorders
    Tsutomu Takahashi
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Victoria, Australia
    Schizophr Res 105:236-44. 2008
    ..These findings suggest that the CSP is not a neurodevelopmental marker of psychosis and cast doubt over the notion that it plays a major role in the neurobiology of psychosis...
  14. ncbi Proton magnetic resonance spectroscopy in first episode psychosis and ultra high-risk individuals
    Stephen J Wood
    Melbourne Neuropsychiatry Centre, University of Melbourne and Sunshine Hospital, Melbourne, Australia
    Schizophr Bull 29:831-43. 2003
    ..This finding did not discriminate between those UHR individuals who later became psychotic and those who did not...
  15. ncbi Superior temporal gyrus volume in antipsychotic-naive people at risk of psychosis
    Tsutomu Takahashi
    Melbourne Neuropsychiatry Centre, c o National Neuroscience Facility, 161 Barry Street, Carlton South, Victoria 3053, Australia
    Br J Psychiatry 196:206-11. 2010
    ..Morphological abnormalities of the superior temporal gyrus have been consistently reported in schizophrenia, but the timing of their occurrence remains unclear...
  16. ncbi Corpus callosum shape alterations in individuals prior to the onset of psychosis
    Mark Walterfang
    Melbourne Neuropsychiatry Centre and Department of Psychiatry, University of Melbourne, North Western Mental Health Program, Sunshine Hospital, Melbourne, Australia
    Schizophr Res 103:1-10. 2008
    ..These changes may reflect primary pathology of orbitofrontal and medial frontal cortex, or deficits in anterior interhemispheric myelination...
  17. ncbi Ethyl-eicosapentaenoic acid in first-episode psychosis. A 1H-MRS study
    Gregor E Berger
    Department of Psychiatry, ORYGEN Research Centre, University of Melbourne, Parkville, Australia
    Neuropsychopharmacology 33:2467-73. 2008
    ..Larger confirmatory studies of these postulated metabolic brain effects of E-EPA are warranted...
  18. ncbi Anterior cingulate glutamate-glutamine levels predict symptom severity in women with obsessive-compulsive disorder
    Murat Yucel
    Melbourne Neuropsychiatry Centre, National Neuroscience Facility, Carlton South, Australia
    Aust N Z J Psychiatry 42:467-77. 2008
    ..The purpose of the present study was to investigate how ACC biochemistry in OCD varies as a function of gender, hemisphere, subregion, and symptomatology...
  19. ncbi Memory impairments identified in people at ultra-high risk for psychosis who later develop first-episode psychosis
    Warrick J Brewer
    ORYGEN Research Centre, Melbourne, Australia
    Am J Psychiatry 162:71-8. 2005
    ..While cognitive deficits are frequently reported in psychotic disorders, it is unclear whether these impairments predate the onset of illness and to what extent they are predictive of later transition to psychosis...
  20. ncbi Functional and biochemical alterations of the medial frontal cortex in obsessive-compulsive disorder
    Murat Yucel
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Victoria 3053, Australia
    Arch Gen Psychiatry 64:946-55. 2007
    ..However, the precise regions and the neural alterations associated with this abnormality remain unclear...
  21. ncbi Anatomic abnormalities of the anterior cingulate cortex before psychosis onset: an MRI study of ultra-high-risk individuals
    Alex Fornito
    Department of Psychiatry, Melbourne Neuropsychiatry Centre, University of Melbourne, Carlton South, Victoria, Australia
    Biol Psychiatry 64:758-65. 2008
    ..In this study, we characterized prepsychotic ACC abnormalities in a sample of individuals at ultra-high-risk (UHR) for psychosis...
  22. ncbi Insular cortex gray matter changes in individuals at ultra-high-risk of developing psychosis
    Tsutomu Takahashi
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Victoria, Australia
    Schizophr Res 111:94-102. 2009
    ..Whether these longitudinal changes are features of the disorder or related to treatment with antipsychotic medication remains to be determined...
  23. ncbi Anterior cingulate cortex abnormalities associated with a first psychotic episode in bipolar disorder
    Alex Fornito
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, School of Behavioural Science, University of Melbourne, National Neuroscience Facility, 161 Barry Street, Carlton South, VIC 3053, Australia
    Br J Psychiatry 194:426-33. 2009
    ....
  24. ncbi Inhibitory control in young adolescents: the role of sex, intelligence, and temperament
    Murat Yucel
    The University of Melbourne, Melbourne Health, Melbourne, Victoria, Australia
    Neuropsychology 26:347-56. 2012
    ..However, sex differences in inhibitory control are often not expressed experimentally during task performance. Here, we sought to examine how sex, temperament, and intelligence are related to different aspects of inhibitory control...
  25. ncbi Orbitofrontal, amygdala and hippocampal volumes in teenagers with first-presentation borderline personality disorder
    Andrew M Chanen
    ORYGEN Research Centre, Department of Psychiatry, The University of Melbourne, Melbourne, Australia
    Psychiatry Res 163:116-25. 2008
    ..Hippocampal and amygdala volume reductions observed in adult BPD samples might develop during the course of the disorder, although longitudinal studies are needed to examine this...
  26. ncbi Follow-up MRI study of the insular cortex in first-episode psychosis and chronic schizophrenia
    Tsutomu Takahashi
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Victoria, Australia
    Schizophr Res 108:49-56. 2009
    ....
  27. ncbi Surface-based morphometry of the anterior cingulate cortex in first episode schizophrenia
    Alex Fornito
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Australia
    Hum Brain Mapp 29:478-89. 2008
    ....
  28. ncbi Caudate nucleus volume in individuals at ultra-high risk of psychosis: a cross-sectional magnetic resonance imaging study
    Katrina L Hannan
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Parkville, Victoria, Australia
    Psychiatry Res 182:223-30. 2010
    ..Future research should examine changes longitudinally together with analysis of shape to assess subregions of the caudate that connect with prefrontal cortex...
  29. ncbi Corpus callosum size and shape in first-episode affective and schizophrenia-spectrum psychosis
    Mark Walterfang
    Melbourne Neuropsychiatry Centre, University of Melbourne, Melbourne, Australia
    Psychiatry Res 173:77-82. 2009
    ..This suggests that schizoaffective disorder may represent two interacting illness processes or be mid-way along a continuum of these two broad categories of illness at first psychosis...
  30. ncbi Hippocampal and amygdala volumes according to psychosis stage and diagnosis: a magnetic resonance imaging study of chronic schizophrenia, first-episode psychosis, and ultra-high-risk individuals
    Dennis Velakoulis
    Melbourne Neuropsychiatry Centre and Department of Psychiatry, University of Melbourne, Australia
    Arch Gen Psychiatry 63:139-49. 2006
    ..These studies have been limited by small samples and the absence of patients early in the course of illness...
  31. ncbi Grey and white matter abnormalities are associated with impaired spatial working memory ability in first-episode schizophrenia
    Luca Cocchi
    Department of Psychiatry, Melbourne Neuropsychiatry Centre, The University of Melbourne and Melbourne Health, Melbourne, Australia
    Schizophr Res 115:163-72. 2009
    ....
  32. ncbi Relational memory in first episode psychosis: implications for progressive hippocampal dysfunction after illness onset
    Cali F Bartholomeusz
    National Neuroscience Facility, Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne, Carlton South, Victoria, Australia
    Aust N Z J Psychiatry 45:206-13. 2011
    ....
  33. ncbi Midline brain abnormalities in established bipolar affective disorder
    Tsutomu Takahashi
    Department of Psychiatry, University of Melbourne and Melbourne Health, Melbourne Neuropsychiatry Centre, Victoria, Australia
    J Affect Disord 122:301-5. 2010
    ..Morphologic changes of cortico-limbic regions have been reported in bipolar disorder, but it remains unclear whether midline brain abnormalities relevant to cortico-limbic connectivity are also present...
  34. ncbi Gray matter reduction of the superior temporal gyrus in patients with established bipolar I disorder
    Tsutomu Takahashi
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Victoria, Australia
    J Affect Disord 123:276-82. 2010
    ..Functional abnormalities of the superior temporal gyrus (STG) have been implicated in the pathophysiology of bipolar disorder, but magnetic resonance imaging (MRI) studies of this region have yielded inconsistent findings...
  35. ncbi Adhesio interthalamica in individuals at high-risk for developing psychosis and patients with psychotic disorders
    Tsutomu Takahashi
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Victoria, Australia
    Prog Neuropsychopharmacol Biol Psychiatry 32:1708-14. 2008
    ....
  36. ncbi Attentional set-shifting ability in first-episode and established schizophrenia: Relationship to working memory
    Christos Pantelis
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Sunshine Hospital, St Albans, Victoria 3021, Australia
    Schizophr Res 112:104-13. 2009
    ..Longitudinal studies assessing these cognitive functions from illness onset or in prepsychotic individuals are required...
  37. ncbi An MRI study of pituitary volume and parasuicidal behavior in teenagers with first-presentation borderline personality disorder
    Martina Jovev
    ORYGEN Research Centre, Department of Psychiatry, The University of Melbourne, Melbourne, Australia
    Psychiatry Res 162:273-7. 2008
    ..Further studies are required using direct neuroendocrine measures and exploring other parameters of self-injurious behavior, such as recency of self-injurious behavior, intent to die and medical threat...
  38. ncbi Neuroanatomical abnormalities before and after onset of psychosis: a cross-sectional and longitudinal MRI comparison
    Christos Pantelis
    Cognitive Neuropsychiatry Research and Academic Unit, and Melbourne Neuropsychiatry Centre, Mental Health Programme, Department of Psychiatry, University of Melbourne and Sunshine Hospital, Victoria, Melbourne, Australia
    Lancet 361:281-8. 2003
    ..We investigated this issue with MRI to study people with prodromal symptoms who are at ultra high-risk for the development of psychosis...
  39. ncbi Pituitary volume in patients with bipolar disorder and their first-degree relatives
    Tsutomu Takahashi
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Victoria, Australia
    J Affect Disord 124:256-61. 2010
    ..In addition, the contribution of genetic factors to the pituitary changes in BD remains largely unknown...
  40. ncbi An MRI study of the superior temporal subregions in first-episode patients with various psychotic disorders
    Tsutomu Takahashi
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Victoria, Australia
    Schizophr Res 113:158-66. 2009
    ..Our findings indicate that morphologic abnormalities of the STG gray matter are specific to schizophrenia among various psychotic disorders, implicating its role in the underlying pathophysiology of schizophrenia...
  41. ncbi Superior temporal gyrus volume in teenagers with first-presentation borderline personality disorder
    Tsutomu Takahashi
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Melbourne, Australia
    Psychiatry Res 182:73-6. 2010
    ..Our preliminary findings might reflect the neurobiological heterogeneity of the disorder...
  42. ncbi The effect of atypical antipsychotics on pituitary gland volume in patients with first-episode psychosis: a longitudinal MRI study
    John Paul Nicolo
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Australia
    Schizophr Res 116:49-54. 2010
    ..Qualifying and quantifying the effect of atypical antipsychotics on the volume of the pituitary gland will determine whether this measure is valid as a future estimate of HPA-axis activation in psychotic populations...
  43. ncbi Insular cortex volume and impulsivity in teenagers with first-presentation borderline personality disorder
    Tsutomu Takahashi
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Melbourne, Australia
    Prog Neuropsychopharmacol Biol Psychiatry 33:1395-400. 2009
    ..Further studies are needed to clarify whether the potential relationship between the insular cortex volume and impulsivity is specific to BPD...
  44. ncbi Increased pituitary volume in patients with established bipolar affective disorder
    Tsutomu Takahashi
    Department of Psychiatry, Melbourne Neuropsychiatry Centre, University of Melbourne and Melbourne Health, Victoria, Australia
    Prog Neuropsychopharmacol Biol Psychiatry 33:1245-9. 2009
    ..psychotic and nonpsychotic). Pituitary volume was larger in females than in males for both groups. These results support previous neuroendocrine findings that implicate HPA axis dysfunction in the core pathophysiological process of BD...
  45. ncbi Diagnostic specificity of the insular cortex abnormalities in first-episode psychotic disorders
    Tsutomu Takahashi
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Victoria, Australia
    Prog Neuropsychopharmacol Biol Psychiatry 33:651-7. 2009
    ..These findings suggest that the widespread volume reduction of the insular cortex is specific to established schizophrenia, implicating its role in the neurobiology of clinical characteristics associated with schizophrenia...
  46. ncbi Phenylthiocarbamide (PTC) perception in ultra-high risk for psychosis participants who develop schizophrenia: testing the evidence for an endophenotypic marker
    Warrick J Brewer
    Orygen Youth Health Research Centre, University of Melbourne, Melbourne, Australia
    Psychiatry Res 199:8-11. 2012
    ....
  47. ncbi Amygdala and insula volumes prior to illness onset in bipolar disorder: a magnetic resonance imaging study
    Andreas Bechdolf
    Department of Psychiatry, University of Cologne, Germany
    Psychiatry Res 201:34-9. 2012
    ..If these findings are confirmed, they suggest that imaging investigations could help to distinguish people who will subsequently develop bipolar disorder from those who will not, at least in symptomatically enriched samples...
  48. ncbi Neuroprotective effects of low-dose lithium in individuals at ultra-high risk for psychosis. A longitudinal MRI/MRS study
    Gregor E Berger
    Orygen Youth Health Research Centre, Locked Bag 10, Parkville, Victoria, 3052, Australia
    Curr Pharm Des 18:570-5. 2012
    ..To investigate if low-dose lithium may counteract the microstructural and metabolic brain changes proposed to occur in individuals at ultra-high risk (UHR) for psychosis...
  49. ncbi Evidence for neuronal dysfunction in the anterior cingulate of patients with schizophrenia: a proton magnetic resonance spectroscopy study at 3 T
    Stephen J Wood
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne, Australia
    Schizophr Res 94:328-31. 2007
    ..Anterior cingulate involvement in schizophrenia is likely to be a result of neuronal loss or dysfunction...
  50. ncbi Midline brain structures in teenagers with first-presentation borderline personality disorder
    Tsutomu Takahashi
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Melbourne, Australia
    Prog Neuropsychopharmacol Biol Psychiatry 33:842-6. 2009
    ..These preliminary findings suggest that ongoing neuroimaging studies should further evaluate a potential involvement of midline brain structures in the pathogenesis of BPD...
  51. ncbi Morphology of the corpus callosum at different stages of schizophrenia: cross-sectional study in first-episode and chronic illness
    Mark Walterfang
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne North Western Mental Health Program, Sunshine Hospital, Royal Melbourne Hospital, Melbourne corrected
    Br J Psychiatry 192:429-34. 2008
    ..The shape of the corpus callosum may differ in schizophrenia, although no study has compared first-episode with established illness...
  52. ncbi Morphology of the paracingulate sulcus and executive cognition in schizophrenia
    Alex Fornito
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne, National Neuroscience Facility, Levels 2 and 3, Alan Gilbert Building, 161 Barry St, Carlton South, Victoria 3053, Australia
    Schizophr Res 88:192-7. 2006
    ..This suggests that prior reports of impaired performance on such tasks in schizophrenia may be partly explained by the reduced frequency of a leftward PCS asymmetry in this population...
  53. ncbi Anatomical abnormalities of the anterior cingulate and paracingulate cortex in patients with bipolar I disorder
    Alex Fornito
    Melbourne Neuropsychiatry Centre, The University of Melbourne, Melbourne, Australia
    Psychiatry Res 162:123-32. 2008
    ..These findings suggest that bipolar disorder is associated with more pronounced changes in the PaC, and that reliance on volumetric measures alone may obscure more subtle differences...
  54. ncbi Early processing deficits in object working memory in first-episode schizophreniform psychosis and established schizophrenia
    Birgit Mathes
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Sunshine Hospital, Melbourne, Australia
    Psychol Med 35:1053-62. 2005
    ..CONCLUSIONS: Our results suggest a deficit in patients with psychotic illness in the initial processes necessary to actively maintain information, such as the ability to form an internal representation of complex objects...
  55. ncbi Insular cortex volume in established bipolar affective disorder: a preliminary MRI study
    Tsutomu Takahashi
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, 161 Barry Street, Carlton South, Victoria 3053, Australia
    Psychiatry Res 182:187-90. 2010
    ....
  56. ncbi Impairment of olfactory identification ability in individuals at ultra-high risk for psychosis who later develop schizophrenia
    Warrick J Brewer
    Department of Psychiatry, University of Melbourne, Melbourne, Australia
    Am J Psychiatry 160:1790-4. 2003
    ..Previous investigation has revealed stable olfactory identification deficits in neuroleptic-naive patients experiencing a first episode of psychosis, but it is unknown if these deficits predate illness onset...
  57. ncbi Progressive brain structural changes mapped as psychosis develops in 'at risk' individuals
    Daqiang Sun
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Parkville, Victoria, Australia
    Schizophr Res 108:85-92. 2009
    ..We hypothesized that progressive volume loss occurs in prefrontal regions during the transition to psychosis...
  58. ncbi Anatomical abnormalities of the anterior cingulate cortex in schizophrenia: bridging the gap between neuroimaging and neuropathology
    Alex Fornito
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne, Victoria, Australia
    Schizophr Bull 35:973-93. 2009
    ..We discuss the potential mechanisms that might facilitate integration of these findings and consider strategies for future research...
  59. ncbi Anterior cingulate activation during Stroop task performance: a PET to MRI coregistration study of individual patients with schizophrenia
    Murat Yucel
    Cognitive Neuropsychiatry Research and Academic Unit, Department of Psychiatry, Howard Florey Institute, University of Melbourne, Victoria, Australia
    Am J Psychiatry 159:251-4. 2002
    ....
  60. ncbi The impact of cannabis use on cognitive functioning in patients with schizophrenia: a meta-analysis of existing findings and new data in a first-episode sample
    Murat Yucel
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, National Neuroscience Facility, Alan Gilbert Building, 161 Barry Street, Carlton South, Victoria 3053, Australia
    Schizophr Bull 38:316-30. 2012
    ....
  61. ncbi State, trait and biochemical influences on human anterior cingulate function
    Murat Yucel
    Melbourne Neuropsychiatry Centre, Australia
    Neuroimage 34:1766-73. 2007
    ..They also highlight the importance of considering enduring personal characteristics when mapping human brain-behavior relationships...
  62. ncbi Olfactory sensitivity through the course of psychosis: Relationships to olfactory identification, symptomatology and the schizophrenia odour
    Warrick J Brewer
    ORYGEN Research Centre, Melbourne, Victoria, Australia
    Psychiatry Res 149:97-104. 2007
    ..This may be linked to olfactory habituation effects, abnormal chemical processing or a genetic predisposition...
  63. ncbi Generalized and specific cognitive performance in clinical high-risk cohorts: a review highlighting potential vulnerability markers for psychosis
    Warrick J Brewer
    ORYGEN Research Centre and Early Psychosis Prevention and Intervention Centre, EPPIC, Department of Psychiatry, University of Melbourne, Australia
    Schizophr Bull 32:538-55. 2006
    ..Delineation of the relationship between specific cognitive ability and symptoms from data-driven approaches may improve our understanding of the role of cognition during psychosis onset...
  64. ncbi Variability of the paracingulate sulcus and morphometry of the medial frontal cortex: associations with cortical thickness, surface area, volume, and sulcal depth
    Alex Fornito
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne, Melbourne, Australia
    Hum Brain Mapp 29:222-36. 2008
    ....
  65. ncbi Pituitary volume predicts future transition to psychosis in individuals at ultra-high risk of developing psychosis
    Belinda Garner
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne, Royal Melbourne Hospital, Melbourne, Australia
    Biol Psychiatry 58:417-23. 2005
    ..032). CONCLUSIONS: The phase before the onset of psychosis is associated with a larger pituitary volume, suggesting activation of the HPA axis...
  66. ncbi Ethyl-eicosapentaenoic acid in first-episode psychosis: a randomized, placebo-controlled trial
    Gregor E Berger
    ORYGEN Research Centre incorporating the Early Psychosis Prevention and Intervention Centre EPPIC, University of Melbourne, Australia
    J Clin Psychiatry 68:1867-75. 2007
    ..To investigate if ethyl-eicosapentaenoic acid (E-EPA) augmentation improves antipsychotic efficacy and tolerability in first-episode psychosis (FEP)...
  67. ncbi Abnormal white matter microstructure in schizophrenia: a voxelwise analysis of axial and radial diffusivity
    Marc L Seal
    Melbourne Neuropsychiatry Centre, The University of Melbourne, Victoria, Australia
    Schizophr Res 101:106-10. 2008
    ..This finding suggests that the loss of white matter integrity in schizophrenia is the result of demyelination and/or changes to the axonal cytoskeleton rather than gross axonal damage...
  68. ncbi Morphology of the anterior cingulate cortex in young men at ultra-high risk of developing a psychotic illness
    Murat Yucel
    Department of Psychiatry, University of Melbourne, Parkville, Victoria, Australia
    Br J Psychiatry 182:518-24. 2003
    ..The anterior cingulate cortex (ACC) is consistently implicated in the pathophysiology of schizophrenia, and our own work has identified morphological anomalies in the ACC of people with this disorder...
  69. ncbi Olfactory impairments in child attention-deficit/hyperactivity disorder
    Felicity R Karsz
    University of Melbourne, Victoria, Australia
    J Clin Psychiatry 69:1462-8. 2008
    ....
  70. ncbi The localization and lateralization of memory deficits in children with temporal lobe epilepsy
    Linda M Gonzalez
    Australian Centre for Child Neuropsychology Studies, Murdoch Children s Research Institute, Melbourne, Australia
    Epilepsia 48:124-32. 2007
    ..Further, differences between mesial and lateral subgroups have not been adequately examined. This study aimed to discern more specific patterns of memory impairment in children with TLE...
  71. ncbi A manual and automated MRI study of anterior cingulate and orbito-frontal cortices, and caudate nucleus in obsessive-compulsive disorder: comparison with healthy controls and patients with schizophrenia
    Jem Riffkin
    Melbourne Neuropsychiatry Centre, University of Melbourne and Sunshine Hospital, Melbourne, Victoria, Australia
    Psychiatry Res 138:99-113. 2005
    ..The findings suggest that in contrast to findings in SCZ, there are very few (if any) gross structural anomalies in OCD...
  72. ncbi Genetic influences on cost-efficient organization of human cortical functional networks
    Alex Fornito
    Brain Mapping Unit, Behavioural and Clinical Neurosciences Institute, University of Cambridge, Cambridge CB2 3EB, United Kingdom
    J Neurosci 31:3261-70. 2011
    ....
  73. ncbi Encoding dysfunctions in a dynamic-static paradigm for visuospatial working memory in first-episode psychosis patients: a 2-year follow-up study
    Luca Cocchi
    Institute of Sport Science and Physical Education, Department of Physiology, Lausanne University, Lausanne, Switzerland
    Early Interv Psychiatry 3:44-51. 2009
    ..To investigate static and dynamic visuospatial working memory (VSWM) processes in first-episode psychosis (FEP) patients and explore the validity of such measures as specific trait markers of schizophrenia...
  74. ncbi Neuropsychological functioning in children with early-treated phenylketonuria: impact of white matter abnormalities
    Peter J Anderson
    Department of Psychology, Royal Children s Hospital, Melbourne, Victoria, Australia
    Dev Med Child Neurol 46:230-8. 2004
    ..However, children with no detectable, or mild WMAs, also displayed cognitive problems, indicating that neuropsychological functioning in children with ETPKU is determined by a complex interaction of biological and environmental factors...
  75. ncbi Early and late neurodevelopmental disturbances in schizophrenia and their functional consequences
    Christos Pantelis
    Cognitive Neuropsychiatry Research and Academic Unit, Sunshine Hospital, 176 Furlong Road, St Albans, 3021, Victoria, Australia
    Aust N Z J Psychiatry 37:399-406. 2003
    ..In this paper we review the timing of structural changes in schizophrenia and argue that schizophrenia is a neuro-developmental disorder with limited progressive brain changes occurring during the evolution and early phase of psychosis...
  76. ncbi Should a "Risk Syndrome for Psychosis" be included in the DSMV?
    Alison R Yung
    Orygen Youth Health Research Centre and Centre for Youth Mental Health, University of Melbourne, 35 Poplar Rd, Parkville, VIC 3052, Australia
    Schizophr Res 120:7-15. 2010
    ..Additionally, there are potential dangerous unintended consequences of the reification of this syndrome as a formal diagnosis. Thus we feel it is premature to justify inclusion of the RS in the DSM...
  77. ncbi The Nine Box Maze Test: A measure of spatial memory development in children
    Linda M Pentland
    Department of Psychology, University of Melbourne, 3010, Victoria, Australia
    Brain Cogn 52:144-54. 2003
    ..The theoretical, assessment and developmental issues raised by these findings are discussed...
  78. ncbi Increased duration of illness is associated with reduced volume in right medial temporal/anterior cingulate grey matter in patients with chronic schizophrenia
    Dennis Velakoulis
    Cognitive Neuropsychiatry Research and Academic Unit, Department of Psychiatry, University of Melbourne and Sunshine Hospital, St Albans, Australia
    Schizophr Res 57:43-9. 2002
    ..The inverse correlation between right frontal, temporal and cerebellar volumes and the time since the onset of schizophrenia could reflect progressive tissue loss following the first episode of the disorder...
  79. ncbi From neuroprogression to neuroprotection: implications for clinical care
    Michael Berk
    Department of Clinical and Biomedical Sciences Barwon Health, University of Melbourne, Melbourne, Vic
    Med J Aust 193:S36-40. 2010
    ..These developments need to be combined with service initiatives to maximise the opportunities for early diagnosis and intervention...
  80. ncbi Visuospatial working memory deficits and visual pursuit impairments are not directly related in schizophrenia
    Luca Cocchi
    Institute of Sport Science and Physical Education, Institute of Psychology, University of Lausanne, Switzerland
    Aust N Z J Psychiatry 43:766-74. 2009
    ..The purpose of the present study was therefore to examine the possible relations between the encoding and the discrimination of dynamic visuospatial stimuli in schizophrenia...
  81. ncbi Are neuropsychological impairments in children with early-treated phenylketonuria (PKU) related to white matter abnormalities or elevated phenylalanine levels?
    Peter J Anderson
    Critical Care and Neurosciences, Murdoch Childrens Research Institute, Melbourne, Australia
    Dev Neuropsychol 32:645-68. 2007
    ..Our findings also offer some support for dopamine depletion in the prefrontal cortex, however adverse consequences as a result of norepinephrine and serotonin deficiencies should not be discounted...
  82. ncbi Implications of lipid biology for the pathogenesis of schizophrenia
    Gregor E Berger
    Early Psychosis Prevention and Intervention Centre, MH SKY EPPIC, Victoria
    Aust N Z J Psychiatry 36:355-66. 2002
    ..Both aspects are proposed as being important in the pathogenesis of schizophrenia. The purpose of this paper is to examine the implications of lipid biology, in particular the role of essential fatty acids (EFA), for schizophrenia...
  83. ncbi Stress, the hippocampus and the hypothalamic-pituitary-adrenal axis: implications for the development of psychotic disorders
    Lisa J Phillips
    Department of Psychology, University of Melbourne, Parkville, Victoria, Australia
    Aust N Z J Psychiatry 40:725-41. 2006
    ..This paper summarizes and discusses evidence supporting a role for HPA-axis dysfunction in the early phase of schizophrenia and related disorders...
  84. ncbi Age of onset of schizophrenia: perspectives from structural neuroimaging studies
    Nitin Gogtay
    Child Psychiatry Branch, National Institute of Mental Health, NIH, Bethesda, MD, USA
    Schizophr Bull 37:504-13. 2011
    ..The importance of examining trajectories of development and the need for future combined approaches, using multimodal imaging together with molecular studies is discussed...
  85. ncbi Sustained attention in young people at high risk of psychosis does not predict transition to psychosis
    Shona M Francey
    PACE Clinic, ORYGEN Youth Health, Locked Bag 10, Parkville, 3052, Australia
    Schizophr Res 79:127-36. 2005
    ..These results support sustained attention as an indicator of vulnerability to psychosis, but suggest that CPT-IP performance does not help to predict transition to psychosis in an ultra high-risk group...
  86. ncbi Pituitary volume in teenagers with first-presentation borderline personality disorder
    Belinda Garner
    ORYGEN Research Centre, Department of Psychiatry, The University of Melbourne, Melbourne, Australia
    Psychiatry Res 156:257-61. 2007
    ..These preliminary findings suggest that exposure to childhood trauma, rather than BPD, per se, might be associated with reduced PGV, possibly reflecting hypothalamic-pituitary-adrenal axis dysfunction...
  87. ncbi Normative data from the CANTAB. I: development of executive function over the lifespan
    Cinzia R De Luca
    Sunshine Hospital and Department of Psychiatry, University of Melbourne, Australia
    J Clin Exp Neuropsychol 25:242-54. 2003
    ..Declines in performance on all tasks were revealed for the 50-64 year old sample, providing support for the vulnerability of executive skills to normal aging...
  88. ncbi Neonate hippocampal volumes: prematurity, perinatal predictors, and 2-year outcome
    Deanne K Thompson
    Howard Florey Institute, Centre for Neuroscience, University of Melbourne, Melbourne, Victoria, Australia
    Ann Neurol 63:642-51. 2008
    ..To compare preterm (PT) and full-term (FT) infant hippocampal volumes and to investigate the relations among PT hippocampal volume, perinatal risk factors, and neurodevelopmental outcome...
  89. ncbi Neuroanatomical correlates of temperament in early adolescents
    Sarah Whittle
    Department of Psychiatry, University of Melbourne, Victoria 3052, Australia
    J Am Acad Child Adolesc Psychiatry 47:682-93. 2008
    ..In the present study, we examined the relation between four core temperament dimensions and anatomically defined regions of the limbic and prefrontal cortices...
  90. ncbi Anterior cingulate dysfunction: implications for psychiatric disorders?
    Murat Yucel
    Melbourne Neuropsychiatry Centre Sunshine Hospital, Department of Psychiatry, University of Melbourne, Parkville, Australia
    J Psychiatry Neurosci 28:350-4. 2003
  91. ncbi Paracingulate morphologic differences in males with established schizophrenia: a magnetic resonance imaging morphometric study
    Murat Yucel
    Cognitive Neuropsychiatry Research and Academic Unit, Department of Psychiatry, The University of Melbourne, Sunshine Hospital, Melbourne, Victoria, Australia
    Biol Psychiatry 52:15-23. 2002
    ..Given the evidence showing an absence or reversal of normal anatomical asymmetries in patients with schizophrenia, the current study examined the anterior cingulate cortex sulcal-gyral patterns in patients with schizophrenia...
  92. ncbi The influence of sulcal variability on morphometry of the human anterior cingulate and paracingulate cortex
    Alex Fornito
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne, Australia
    Neuroimage 33:843-54. 2006
    ....
  93. ncbi Evidence of altered prefrontal-thalamic circuitry in schizophrenia: an optimized diffusion MRI study
    Stephen E Rose
    Centre for Magnetic Resonance, University of Queensland, Brisbane 4072, Australia
    Neuroimage 32:16-22. 2006
    ..001). This study has shown for the first time that MD measures offer an alternative strategy for investigating altered prefrontal-thalamic circuitry in schizophrenia...
  94. ncbi Structural brain imaging evidence for multiple pathological processes at different stages of brain development in schizophrenia
    Christos Pantelis
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne, Royal Melbourne Hospital, Sunshine Hospital, Victoria
    Schizophr Bull 31:672-96. 2005
    ....
  95. ncbi Diseases of white matter and schizophrenia-like psychosis
    Mark Walterfang
    Melbourne Neuropsychiatry Centre, Level 2, John Cade Building, Royal Melbourne Hospital, Melbourne, Victoria 3050, Australia
    Aust N Z J Psychiatry 39:746-56. 2005
    ..To analyse the available data regarding the presentation of psychosis in diseases of central nervous system (CNS) white matter...
  96. ncbi Patient education and informed consent in head and neck surgery
    Yvonne Chan
    Department of Otolaryngology, Wharton Head and Neck Centre, Princess Margaret Hospital, University Health Network, Toronto, Ontario, Canada
    Arch Otolaryngol Head Neck Surg 128:1269-74. 2002
    ..Patients' ability to recall potential risks was significantly increased by an educational intervention; all patients would benefit from this intervention...
  97. ncbi Thalamic and caudate volumes in monozygotic twins discordantfor schizophrenia
    Nicola Bridle
    Cognitive Neuropsychiatry Research and Academic Unit, The University of Melbourne, Parkville, Victoria, Australia
    Aust N Z J Psychiatry 36:347-54. 2002
    ..Such interactions need to be considered in future studies investigating brain structural abnormalities in schizophrenia and other disorders...
  98. ncbi Pituitary volume in psychosis
    Carmine M Pariante
    Division of Psychological Medicine, Institute of Psychiatry, King s College London, UK
    Br J Psychiatry 185:5-10. 2004
    ..Patients with psychosis have activation of the hypothalamic-pituitary-adrenal (HPA) axis during the acute phase of the psychosis. Whether this has any morphological consequences for the pituitary gland is currently unknown...
  99. ncbi Smoking cessation in patients diagnosed with head and neck cancer
    Yvonne Chan
    Department of Otolaryngology/Department of Surgical Oncology, Wharton Head and Neck Centre, Princess Margaret Hospital, University Health Network, Toronto, ON, Canada
    J Otolaryngol 33:75-81. 2004
    ..CONCLUSIONS: Although smoking cessation would be presumed to be high after cancer diagnosis, this study has identified patient subgroups in which postdiagnosis smoking cessation intervention programs need to be made more effective...
  100. ncbi The transition to psychosis: risk factors and brain changes
    Stephen J Wood
    Epidemiol Psichiatr Soc 13:137-40. 2004
  101. ncbi Neuropathological, neurogenetic and neuroimaging evidence for white matter pathology in schizophrenia
    Mark Walterfang
    Melbourne Neuropsychiatry Centre, University of Melbourne, Victoria, Australia
    Neurosci Biobehav Rev 30:918-48. 2006
    ....