L G Wood

Summary

Affiliation: University of Newcastle
Country: Australia

Publications

  1. ncbi request reprint Dietary interventions in asthma
    Hayley A Scott
    Centre for Asthma and Respiratory Diseases, HMRI, Level 2, Locked Bag 1, Hunter Region Mail Centre, NSW, 2310, Australia
    Curr Pharm Des 20:1003-10. 2014
  2. pmc Feasibility of omega-3 fatty acid supplementation as an adjunct therapy for people with chronic obstructive pulmonary disease: study protocol for a randomized controlled trial
    Ashley S Fulton
    Nutritional Physiology Research Centre, Sansom Institute for Health Research, School of Health Sciences, University of South Australia, City East Campus, Frome Road, Adelaide, South Australia 5000, Australia
    Trials 14:107. 2013
  3. doi request reprint The neutrophilic inflammatory phenotype is associated with systemic inflammation in asthma
    Lisa G Wood
    Centre for Asthma and Respiratory Diseases, University of Newcastle, Australia
    Chest 142:86-93. 2012
  4. pmc Relationship between body composition, inflammation and lung function in overweight and obese asthma
    Hayley A Scott
    Respiratory and Sleep Medicine, Hunter Medical Research Institute, John Hunter Hospital, Newcastle, NSW Australia
    Respir Res 13:10. 2012
  5. doi request reprint Mannitol challenge for assessment of airway responsiveness, airway inflammation and inflammatory phenotype in asthma
    L G Wood
    Respiratory and Sleep Medicine, Hunter Medical Research Institute, John Hunter Hospital, New Lambton, NSW, Australia
    Clin Exp Allergy 40:232-41. 2010
  6. doi request reprint Assessment of dietary fat intake and innate immune activation as risk factors for impaired lung function
    L G Wood
    Department of Respiratory and Sleep Medicine, Hunter Medical Research Institute, John Hunter Hospital, NSW, Australia
    Eur J Clin Nutr 64:818-25. 2010
  7. doi request reprint Reduced circulating antioxidant defences are associated with airway hyper-responsiveness, poor control and severe disease pattern in asthma
    Lisa G Wood
    Respiratory and Sleep Medicine, Hunter Medical Research Institute, John Hunter Hospital, Newcastle, NSW, Australia
    Br J Nutr 103:735-41. 2010
  8. doi request reprint Dietary factors lead to innate immune activation in asthma
    Lisa G Wood
    Department of Respiratory and Sleep Medicine, Hunter Medical Research Institute, John Hunter Hospital, Newcastle, 2310 NSW, Australia
    Pharmacol Ther 123:37-53. 2009
  9. doi request reprint Innate immune mechanisms linking non-esterified fatty acids and respiratory disease
    Lisa G Wood
    Department of Respiratory and Sleep Medicine, Level 3, John Hunter Hospital, Hunter Medical Research Institute, Locked Bag 1, Hunter Region Mail Centre, Newcastle, 2310 NSW, Australia
    Prog Lipid Res 48:27-43. 2009
  10. doi request reprint A high-fat challenge increases airway inflammation and impairs bronchodilator recovery in asthma
    Lisa G Wood
    Centre for Asthma and Respiratory Disease, Hunter Medical Research Institute, University of Newcastle, Newcastle, Australia
    J Allergy Clin Immunol 127:1133-40. 2011

Collaborators

Detail Information

Publications36

  1. ncbi request reprint Dietary interventions in asthma
    Hayley A Scott
    Centre for Asthma and Respiratory Diseases, HMRI, Level 2, Locked Bag 1, Hunter Region Mail Centre, NSW, 2310, Australia
    Curr Pharm Des 20:1003-10. 2014
    ..Chronic excess energy intake can lead to obesity, which augments inflammation due to the release of inflammatory mediators by adipose tissue. Here we review the role of these dietary components in asthma. ..
  2. pmc Feasibility of omega-3 fatty acid supplementation as an adjunct therapy for people with chronic obstructive pulmonary disease: study protocol for a randomized controlled trial
    Ashley S Fulton
    Nutritional Physiology Research Centre, Sansom Institute for Health Research, School of Health Sciences, University of South Australia, City East Campus, Frome Road, Adelaide, South Australia 5000, Australia
    Trials 14:107. 2013
    ..The aim of this article is to discuss the feasibility of conducting a trial to evaluate fish oil supplementation as adjunct therapy in people with COPD...
  3. doi request reprint The neutrophilic inflammatory phenotype is associated with systemic inflammation in asthma
    Lisa G Wood
    Centre for Asthma and Respiratory Diseases, University of Newcastle, Australia
    Chest 142:86-93. 2012
    ..The role of systemic inflammation in asthma is unclear. The aim of this study was to compare systemic inflammation in subjects with stable asthma, categorized by airway inflammatory phenotype, with healthy control subjects...
  4. pmc Relationship between body composition, inflammation and lung function in overweight and obese asthma
    Hayley A Scott
    Respiratory and Sleep Medicine, Hunter Medical Research Institute, John Hunter Hospital, Newcastle, NSW Australia
    Respir Res 13:10. 2012
    ..The obese-asthma phenotype is not well defined. The aim of this study was to examine both mechanical and inflammatory influences, by comparing lung function with body composition and airway inflammation in overweight and obese asthma...
  5. doi request reprint Mannitol challenge for assessment of airway responsiveness, airway inflammation and inflammatory phenotype in asthma
    L G Wood
    Respiratory and Sleep Medicine, Hunter Medical Research Institute, John Hunter Hospital, New Lambton, NSW, Australia
    Clin Exp Allergy 40:232-41. 2010
    ..Assessment of airway inflammation in asthma is becoming increasingly important, as the inflammatory phenotype underpins the treatment response...
  6. doi request reprint Assessment of dietary fat intake and innate immune activation as risk factors for impaired lung function
    L G Wood
    Department of Respiratory and Sleep Medicine, Hunter Medical Research Institute, John Hunter Hospital, NSW, Australia
    Eur J Clin Nutr 64:818-25. 2010
    ..We aimed to determine the association between dietary fat intake and lung function in older people...
  7. doi request reprint Reduced circulating antioxidant defences are associated with airway hyper-responsiveness, poor control and severe disease pattern in asthma
    Lisa G Wood
    Respiratory and Sleep Medicine, Hunter Medical Research Institute, John Hunter Hospital, Newcastle, NSW, Australia
    Br J Nutr 103:735-41. 2010
    ..This highlights the potential role for antioxidant supplementation in these subjects...
  8. doi request reprint Dietary factors lead to innate immune activation in asthma
    Lisa G Wood
    Department of Respiratory and Sleep Medicine, Hunter Medical Research Institute, John Hunter Hospital, Newcastle, 2310 NSW, Australia
    Pharmacol Ther 123:37-53. 2009
    ..Therapeutic strategies aimed at addressing diet-induced innate immune activation are warranted...
  9. doi request reprint Innate immune mechanisms linking non-esterified fatty acids and respiratory disease
    Lisa G Wood
    Department of Respiratory and Sleep Medicine, Level 3, John Hunter Hospital, Hunter Medical Research Institute, Locked Bag 1, Hunter Region Mail Centre, Newcastle, 2310 NSW, Australia
    Prog Lipid Res 48:27-43. 2009
    ..Finally, the review will discuss how the recognition of NEFA as important inflammatory stimulants in respiratory disease, leads to the possibility that pathways involved in lipid metabolism may provide therapeutic targets...
  10. doi request reprint A high-fat challenge increases airway inflammation and impairs bronchodilator recovery in asthma
    Lisa G Wood
    Centre for Asthma and Respiratory Disease, Hunter Medical Research Institute, University of Newcastle, Newcastle, Australia
    J Allergy Clin Immunol 127:1133-40. 2011
    ..Dietary fat activates systemic innate immune responses, but the effect on airway responses is unknown...
  11. doi request reprint Potentially pathogenic bacteria cultured from the sputum of stable asthmatics are associated with increased 8-isoprostane and airway neutrophilia
    Lisa G Wood
    Centre for Asthma and Respiratory Disease, University of Newcastle, Callaghan, NSW, Australia
    Free Radic Res 44:146-54. 2010
    ..The role of bacteria in potentiating neutrophilic asthma warrants further investigation. Therapies such as antibiotic and antioxidant treatment may be most effective in this sub-group of patients...
  12. doi request reprint Lycopene-rich treatments modify noneosinophilic airway inflammation in asthma: proof of concept
    Lisa G Wood
    Department of Respiratory and Sleep Medicine, Hunter Medical Research Institute, John Hunter Hospital, Newcastle, NSW, Australia
    Free Radic Res 42:94-102. 2008
    ..Changing dietary antioxidant intake may be contributing to rising asthma prevalence. Lycopene-rich supplements should be further investigated as a therapeutic intervention...
  13. doi request reprint Oxidized vitamin E and glutathione as markers of clinical status in asthma
    Lisa G Wood
    Department of Respiratory and Sleep Medicine, Level 3, Hunter Medical Research Institute, John Hunter Hospital, Locked Bag 1, Hunter Region Mail Centre, Newcastle, 2310 NSW, Australia
    Clin Nutr 27:579-86. 2008
    ....
  14. ncbi request reprint Persistent airway obstruction after virus infection is not associated with airway inflammation
    Lisa G Wood
    School of Medicine and Public Health, University of Newcastle, Newcastle, NSW, Australia
    Chest 131:415-23. 2007
    ..This study examined the contribution of airway inflammation to the delayed lung function recovery that occurs in some people following virus-induced asthma exacerbations...
  15. doi request reprint Antioxidant and anti-inflammatory effects of resveratrol in airway disease
    Lisa G Wood
    Department of Respiratory and Sleep Medicine, Hunter Medical Research Institute, John Hunter Hospital, Newcastle, NSW, Australia
    Antioxid Redox Signal 13:1535-48. 2010
    ..Mechanisms of resveratrol action that may be relevant to respiratory disease are described. We conclude that resveratrol has potential as a therapeutic agent in respiratory disease, which should be further investigated...
  16. doi request reprint Airway inflammation is augmented by obesity and fatty acids in asthma
    H A Scott
    Dept of Respiratory and Sleep Medicine, Hunter Medical Research Institute, Newcastle, NSW, Australia
    Eur Respir J 38:594-602. 2011
    ..This relationship was significant only in females with asthma. In males, saturated and monounsaturated fatty acids were important predictors of neutrophilic airway inflammation in asthma...
  17. doi request reprint Diet-induced weight loss in obese children with asthma: a randomized controlled trial
    M E Jensen
    Centre for Asthma and Respiratory Diseases, University of Newcastle, Newcastle, NSW, Australia
    Clin Exp Allergy 43:775-84. 2013
    ..Obesity is highly prevalent in asthmatic children and associated with worse clinical outcomes. Energy restriction to induce weight loss in asthmatic children has not been investigated in a randomized controlled trial (RCT)...
  18. doi request reprint Dietary restriction and exercise improve airway inflammation and clinical outcomes in overweight and obese asthma: a randomized trial
    H A Scott
    Respiratory and Sleep Medicine, Hunter Medical Research Institute, John Hunter Hospital, Newcastle, NSW, Australia
    Clin Exp Allergy 43:36-49. 2013
    ..Obesity and asthma are associated conditions; however, the mechanisms linking the two remain unclear. Few studies have examined the effects of weight loss on inflammation and clinical outcomes in obese-asthma...
  19. ncbi request reprint Airway and circulating levels of carotenoids in asthma and healthy controls
    Lisa G Wood
    Department Respiratory and Sleep Medicine, John Hunter Hospital, Locked Bag 1, Hunter Region Mail Centre, NSW, 2310, Australia
    J Am Coll Nutr 24:448-55. 2005
    ..Elevated oxidative stress and impaired antioxidant defences are increasingly recognised features of asthma. Carotenoids are potent dietary antioxidants that may protect against asthma by reducing oxidative damage...
  20. doi request reprint The obesity phenotype in children with asthma
    M E Jensen
    Department of Respiratory and Sleep Medicine, Hunter Medical Research Institute, John Hunter Hospital, Newcastle, 2310, NSW, Australia
    Paediatr Respir Rev 12:152-9. 2011
    ..This will lead to refinements in management approaches for these patients...
  21. ncbi request reprint Oxidative stress in cystic fibrosis: dietary and metabolic factors
    L G Wood
    Discipline of Nutrition and Dietetics, University of Newcastle, Callaghan, New South Wales, Australia
    J Am Coll Nutr 20:157-65. 2001
    ..The immune response appears to be a key factor causing oxidative stress. Antioxidant intervention aimed at reducing oxidative stress in CF needs to be assessed...
  22. ncbi request reprint Induced sputum 8-isoprostane concentrations in inflammatory airway diseases
    Lisa G Wood
    Department of Respiratory and Sleep Medicine, John Hunter Hospital, Locked Bag 1, Hunter Region Mail Centre, NSW, 2310, Australia
    Am J Respir Crit Care Med 171:426-30. 2005
    ..Analysis of 8-iso-PGF(2alpha) concentrations in induced sputum provides a useful tool for monitoring oxidative stress and investigating strategies aimed at reducing oxidative stress in airways disease...
  23. doi request reprint Characterization of innate immune signalling receptors in virus-induced acute asthma
    L G Wood
    Centre for Asthma and Respiratory Diseases, University of Newcastle, Callaghan, NSW, Australia
    Clin Exp Allergy 41:640-8. 2011
    ..The role of toll-like receptors (TLRs) and innate immune activation in clinical asthma exacerbations and their relationship to virus infection are unclear...
  24. doi request reprint Lyprinol reduces inflammation and improves lung function in a mouse model of allergic airways disease
    L G Wood
    Centre for Asthma and Respiratory Diseases and Hunter Medical Research Institute, The University of Newcastle, Newcastle, NSW, Australia
    Clin Exp Allergy 40:1785-93. 2010
    ..Recent dietary changes, including a decreased ω-3 polyunsaturated fatty acid (PUFA) intake, may have contributed to increased asthma rates and dietary supplementation with marine oil could have clinical benefits...
  25. ncbi request reprint Biomarkers of lipid peroxidation, airway inflammation and asthma
    L G Wood
    Hunter Medical Research Institute, Dept of Respiratory and Sleep Medicine, John Hunter Hospital, New Lambton Heights, Australia
    Eur Respir J 21:177-86. 2003
    ..However, the development of techniques to study isoprostanes in airway-lining fluid pave the way for further studies investigating the potential for antioxidant supplements to be used as routine therapy in asthma...
  26. doi request reprint Transcriptional phenotypes of asthma defined by gene expression profiling of induced sputum samples
    Katherine J Baines
    Centre for Asthma and Respiratory Diseases, Hunter Medical Research Institute, University of Newcastle, Callaghan, Australia
    J Allergy Clin Immunol 127:153-60, 160.e1-9. 2011
    ..Previous studies have identified clinical or inflammatory phenotypes of asthma on the basis of clinical and demographic parameters or sputum cell counts; however, few studies have defined transcriptional phenotypes of asthma...
  27. doi request reprint The nutrigenomics of asthma: molecular mechanisms of airway neutrophilia following dietary antioxidant withdrawal
    Katherine J Baines
    Priority Research Centre for Asthma and Respiratory Diseases, University of Newcastle, Callaghan NSW Australia
    OMICS 13:355-65. 2009
    ..A diet low in antioxidants may be contributing to the development of neutrophilic asthma through activation of the innate immune response...
  28. ncbi request reprint Increased plasma fatty acid concentrations after respiratory exacerbations are associated with elevated oxidative stress in cystic fibrosis patients
    Lisa G Wood
    Discipline of Nutrition and Dietetics, The University of Newcastle, Callaghan, New South Wales, Australia
    Am J Clin Nutr 75:668-75. 2002
    ..Oxidative stress and depleted antioxidant defenses occur in stable cystic fibrosis patients. During acute infection, the balance between oxidants and antioxidants may be further disturbed...
  29. doi request reprint Soluble RAGE is deficient in neutrophilic asthma and COPD
    M B Sukkar
    Respiratory Research Group, Faculty of Pharmacy, University of Sydney, Sydney, Australia
    Eur Respir J 39:721-9. 2012
    ..HMGB1 levels were similar in all subject groups, while SAA was below detectable levels. Neutrophilic airway inflammation in asthma and COPD is associated with reduced sRAGE...
  30. ncbi request reprint Improved antioxidant and fatty acid status of patients with cystic fibrosis after antioxidant supplementation is linked to improved lung function
    Lisa G Wood
    Discipline of Nutrition and Dietetics, Faculty of Health, University of Newcastle, Callaghan, NSW, Australia
    Am J Clin Nutr 77:150-9. 2003
    ..The plasma fatty acid status of CF patients was linked to oxidative stress after respiratory exacerbations...
  31. doi request reprint Sputum ADAM8 expression is increased in severe asthma and COPD
    K M Oreo
    Virus Infections Immunity Vaccines and Asthma, Hunter Medical Research Institute, New Lambton Heights, NSW, Australia Priority Research Centre for Asthma and Respiratory Diseases, The University of Newcastle, Callaghan, NSW, Australia Severe Asthma Network, Woolcock Institute of Medical Research, Glebe, NSW, Australia The University of Sydney, Camperdown Darlington, NSW, Australia
    Clin Exp Allergy 44:342-52. 2014
    ..A disintegrin and metalloproteinase domain 8 (ADAM8) is an enzyme expressed on most leucocytes and may be important for facilitating leucocyte migration in respiratory disease...
  32. ncbi request reprint Hypothesis: vitamin E complements polyunsaturated fatty acids in essential fatty acid deficiency in cystic fibrosis
    Lisa G Wood
    Discipline of Nutrition and Dietetics, University of Newcastle, Callaghan, New South Wales 2308, Australia
    J Am Coll Nutr 22:253-7. 2003
    ..Furthermore, antioxidant supplementation in CF may improve EFA status...
  33. doi request reprint Lycopene enrichment of cultured airway epithelial cells decreases the inflammation induced by rhinovirus infection and lipopolysaccharide
    Ahmad Saedisomeolia
    Nutraceuticals Research Group, School of Biomedical Sciences, University of Newcastle, NSW 2308, Australia
    J Nutr Biochem 20:577-85. 2009
    ..Lycopene also decreased the release of IL-6 and IP-10 following exposure to lipopolysaccharide. We conclude that lycopene has a potential role in suppressing rhinovirus induced airway inflammation...
  34. ncbi request reprint Saturated fat consumption may not be the main cause of increased blood lipid levels
    C B Dias
    Nutraceuticals Research Group, School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, NSW, Australia
    Med Hypotheses 82:187-95. 2014
    ....
  35. doi request reprint Anti-inflammatory effects of long-chain n-3 PUFA in rhinovirus-infected cultured airway epithelial cells
    Ahmad Saedisomeolia
    Nutraceuticals Research Group, School of Biomedical Sciences, University of Newcastle, Newcastle, NSW, Australia
    Br J Nutr 101:533-40. 2009
    ..EPA and AA did not change the release of inflammatory biomarkers significantly. It is concluded that DHA has a potential role in suppressing RV-induced airway inflammation...
  36. pmc Validity of the common cold questionnaire (CCQ) in asthma exacerbations
    Heather Powell
    Department of Respiratory and Sleep Medicine, Hunter Medical Research Institute, John Hunter Hospital, New Lambton, New South Wales, Australia
    PLoS ONE 3:e1802. 2008
    ..Its usefulness in people with acute asthma is unknown. Our aim was to assess the ability of the CCQ to detect viral infection and to monitor recovery during a viral induced asthma exacerbation and confirmed by virological testing...