Research Topics
Species | L G WoodSummaryAffiliation: University of Newcastle Country: Australia Publications
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Publications
The neutrophilic inflammatory phenotype is associated with systemic inflammation in asthmaLisa G Wood
Centre for Asthma and Respiratory Diseases, University of Newcastle, Australia
Chest 142:86-93. 2012..The role of systemic inflammation in asthma is unclear. The aim of this study was to compare systemic inflammation in subjects with stable asthma, categorized by airway inflammatory phenotype, with healthy control subjects...
Relationship between body composition, inflammation and lung function in overweight and obese asthmaHayley A Scott
Respiratory and Sleep Medicine, Hunter Medical Research Institute, John Hunter Hospital, Newcastle, NSW Australia
Respir Res 13:10. 2012..The obese-asthma phenotype is not well defined. The aim of this study was to examine both mechanical and inflammatory influences, by comparing lung function with body composition and airway inflammation in overweight and obese asthma...- Assessment of dietary fat intake and innate immune activation as risk factors for impaired lung functionL G Wood
Department of Respiratory and Sleep Medicine, Hunter Medical Research Institute, John Hunter Hospital, NSW, Australia
Eur J Clin Nutr 64:818-25. 2010..We aimed to determine the association between dietary fat intake and lung function in older people... - Dietary factors lead to innate immune activation in asthmaLisa G Wood
Department of Respiratory and Sleep Medicine, Hunter Medical Research Institute, John Hunter Hospital, Newcastle, 2310 NSW, Australia
Pharmacol Ther 123:37-53. 2009..Therapeutic strategies aimed at addressing diet-induced innate immune activation are warranted... - A high-fat challenge increases airway inflammation and impairs bronchodilator recovery in asthmaLisa G Wood
Centre for Asthma and Respiratory Disease, Hunter Medical Research Institute, University of Newcastle, Newcastle, Australia
J Allergy Clin Immunol 127:1133-40. 2011..Dietary fat activates systemic innate immune responses, but the effect on airway responses is unknown... - Lycopene-rich treatments modify noneosinophilic airway inflammation in asthma: proof of conceptLisa G Wood
Department of Respiratory and Sleep Medicine, Hunter Medical Research Institute, John Hunter Hospital, Newcastle, NSW, Australia
Free Radic Res 42:94-102. 2008..Changing dietary antioxidant intake may be contributing to rising asthma prevalence. Lycopene-rich supplements should be further investigated as a therapeutic intervention... - Oxidized vitamin E and glutathione as markers of clinical status in asthmaLisa G Wood
Department of Respiratory and Sleep Medicine, Level 3, Hunter Medical Research Institute, John Hunter Hospital, Locked Bag 1, Hunter Region Mail Centre, Newcastle, 2310 NSW, Australia
Clin Nutr 27:579-86. 2008.... 
Persistent airway obstruction after virus infection is not associated with airway inflammationLisa G Wood
School of Medicine and Public Health, University of Newcastle, Newcastle, NSW, Australia
Chest 131:415-23. 2007..This study examined the contribution of airway inflammation to the delayed lung function recovery that occurs in some people following virus-induced asthma exacerbations...- Reduced circulating antioxidant defences are associated with airway hyper-responsiveness, poor control and severe disease pattern in asthmaLisa G Wood
Respiratory and Sleep Medicine, Hunter Medical Research Institute, John Hunter Hospital, Newcastle, NSW, Australia
Br J Nutr 103:735-41. 2010..This highlights the potential role for antioxidant supplementation in these subjects... - Mannitol challenge for assessment of airway responsiveness, airway inflammation and inflammatory phenotype in asthmaL G Wood
Respiratory and Sleep Medicine, Hunter Medical Research Institute, John Hunter Hospital, New Lambton, NSW, Australia
Clin Exp Allergy 40:232-41. 2010..Assessment of airway inflammation in asthma is becoming increasingly important, as the inflammatory phenotype underpins the treatment response... - Potentially pathogenic bacteria cultured from the sputum of stable asthmatics are associated with increased 8-isoprostane and airway neutrophiliaLisa G Wood
Centre for Asthma and Respiratory Disease, University of Newcastle, Callaghan, NSW, Australia
Free Radic Res 44:146-54. 2010..The role of bacteria in potentiating neutrophilic asthma warrants further investigation. Therapies such as antibiotic and antioxidant treatment may be most effective in this sub-group of patients... - Antioxidant and anti-inflammatory effects of resveratrol in airway diseaseLisa G Wood
Department of Respiratory and Sleep Medicine, Hunter Medical Research Institute, John Hunter Hospital, Newcastle, NSW, Australia
Antioxid Redox Signal 13:1535-48. 2010..Mechanisms of resveratrol action that may be relevant to respiratory disease are described. We conclude that resveratrol has potential as a therapeutic agent in respiratory disease, which should be further investigated... - Innate immune mechanisms linking non-esterified fatty acids and respiratory diseaseLisa G Wood
Department of Respiratory and Sleep Medicine, Level 3, John Hunter Hospital, Hunter Medical Research Institute, Locked Bag 1, Hunter Region Mail Centre, Newcastle, 2310 NSW, Australia
Prog Lipid Res 48:27-43. 2009..Finally, the review will discuss how the recognition of NEFA as important inflammatory stimulants in respiratory disease, leads to the possibility that pathways involved in lipid metabolism may provide therapeutic targets... - Airway inflammation is augmented by obesity and fatty acids in asthmaH A Scott
Dept of Respiratory and Sleep Medicine, Hunter Medical Research Institute, Newcastle, NSW, Australia
Eur Respir J 38:594-602. 2011..This relationship was significant only in females with asthma. In males, saturated and monounsaturated fatty acids were important predictors of neutrophilic airway inflammation in asthma... - Airway and circulating levels of carotenoids in asthma and healthy controlsLisa G Wood
Department Respiratory and Sleep Medicine, John Hunter Hospital, Locked Bag 1, Hunter Region Mail Centre, NSW, 2310, Australia
J Am Coll Nutr 24:448-55. 2005..Plasma carotenoid levels reflect airway carotenoid levels and when plasma levels are improved using oral supplements this is reflected in the airways... - The obesity phenotype in children with asthmaM E Jensen
Department of Respiratory and Sleep Medicine, Hunter Medical Research Institute, John Hunter Hospital, Newcastle, 2310, NSW, Australia
Paediatr Respir Rev 12:152-9. 2011..This will lead to refinements in management approaches for these patients... - Oxidative stress in cystic fibrosis: dietary and metabolic factorsL G Wood
Discipline of Nutrition and Dietetics, University of Newcastle, Callaghan, New South Wales, Australia
J Am Coll Nutr 20:157-65. 2001..The immune response appears to be a key factor causing oxidative stress. Antioxidant intervention aimed at reducing oxidative stress in CF needs to be assessed... - Induced sputum 8-isoprostane concentrations in inflammatory airway diseasesLisa G Wood
Department of Respiratory and Sleep Medicine, John Hunter Hospital, Locked Bag 1, Hunter Region Mail Centre, NSW, 2310, Australia
Am J Respir Crit Care Med 171:426-30. 2005..Analysis of 8-iso-PGF(2alpha) concentrations in induced sputum provides a useful tool for monitoring oxidative stress and investigating strategies aimed at reducing oxidative stress in airways disease... - Characterization of innate immune signalling receptors in virus-induced acute asthmaL G Wood
Centre for Asthma and Respiratory Diseases, University of Newcastle, Callaghan, NSW, Australia
Clin Exp Allergy 41:640-8. 2011..The role of toll-like receptors (TLRs) and innate immune activation in clinical asthma exacerbations and their relationship to virus infection are unclear... - Biomarkers of lipid peroxidation, airway inflammation and asthmaL G Wood
Hunter Medical Research Institute, Dept of Respiratory and Sleep Medicine, John Hunter Hospital, New Lambton Heights, Australia
Eur Respir J 21:177-86. 2003..However, the development of techniques to study isoprostanes in airway-lining fluid pave the way for further studies investigating the potential for antioxidant supplements to be used as routine therapy in asthma... - Lyprinol reduces inflammation and improves lung function in a mouse model of allergic airways diseaseL G Wood
Centre for Asthma and Respiratory Diseases and Hunter Medical Research Institute, The University of Newcastle, Newcastle, NSW, Australia
Clin Exp Allergy 40:1785-93. 2010..Recent dietary changes, including a decreased ω-3 polyunsaturated fatty acid (PUFA) intake, may have contributed to increased asthma rates and dietary supplementation with marine oil could have clinical benefits... - Transcriptional phenotypes of asthma defined by gene expression profiling of induced sputum samplesKatherine J Baines
Centre for Asthma and Respiratory Diseases, Hunter Medical Research Institute, University of Newcastle, Callaghan, Australia
J Allergy Clin Immunol 127:153-60, 160.e1-9. 2011..Previous studies have identified clinical or inflammatory phenotypes of asthma on the basis of clinical and demographic parameters or sputum cell counts; however, few studies have defined transcriptional phenotypes of asthma... - The nutrigenomics of asthma: molecular mechanisms of airway neutrophilia following dietary antioxidant withdrawalKatherine J Baines
Priority Research Centre for Asthma and Respiratory Diseases, University of Newcastle, Callaghan NSW Australia
OMICS 13:355-65. 2009..A diet low in antioxidants may be contributing to the development of neutrophilic asthma through activation of the innate immune response... - Increased plasma fatty acid concentrations after respiratory exacerbations are associated with elevated oxidative stress in cystic fibrosis patientsLisa G Wood
Discipline of Nutrition and Dietetics, The University of Newcastle, Callaghan, New South Wales, Australia
Am J Clin Nutr 75:668-75. 2002..Thus, antioxidant intervention during treatment for and recovery from acute infection in cystic fibrosis should be considered... - Dietary restriction and exercise improve airway inflammation and clinical outcomes in overweight and obese asthma: a randomized trialH A Scott
Respiratory and Sleep Medicine, Hunter Medical Research Institute, John Hunter Hospital, Newcastle, NSW, Australia
Clin Exp Allergy 43:36-49. 2013..Obesity and asthma are associated conditions; however, the mechanisms linking the two remain unclear. Few studies have examined the effects of weight loss on inflammation and clinical outcomes in obese-asthma... - Soluble RAGE is deficient in neutrophilic asthma and COPDM B Sukkar
Respiratory Research Group, Faculty of Pharmacy, University of Sydney, Sydney, Australia
Eur Respir J 39:721-9. 2012..HMGB1 levels were similar in all subject groups, while SAA was below detectable levels. Neutrophilic airway inflammation in asthma and COPD is associated with reduced sRAGE... - Improved antioxidant and fatty acid status of patients with cystic fibrosis after antioxidant supplementation is linked to improved lung functionLisa G Wood
Discipline of Nutrition and Dietetics, Faculty of Health, University of Newcastle, Callaghan, NSW, Australia
Am J Clin Nutr 77:150-9. 2003..If oxidative stress is deemed to be important to the clinical outcome of CF patients, means of reducing oxidative stress while maintaining a high-fat, high-energy diet must be investigated... - Lycopene enrichment of cultured airway epithelial cells decreases the inflammation induced by rhinovirus infection and lipopolysaccharideAhmad Saedisomeolia
Nutraceuticals Research Group, School of Biomedical Sciences, University of Newcastle, NSW 2308, Australia
J Nutr Biochem 20:577-85. 2009..Lycopene also decreased the release of IL-6 and IP-10 following exposure to lipopolysaccharide. We conclude that lycopene has a potential role in suppressing rhinovirus induced airway inflammation... - Hypothesis: vitamin E complements polyunsaturated fatty acids in essential fatty acid deficiency in cystic fibrosisLisa G Wood
Discipline of Nutrition and Dietetics, University of Newcastle, Callaghan, New South Wales 2308, Australia
J Am Coll Nutr 22:253-7. 2003..Furthermore, antioxidant supplementation in CF may improve EFA status... - Anti-inflammatory effects of long-chain n-3 PUFA in rhinovirus-infected cultured airway epithelial cellsAhmad Saedisomeolia
Nutraceuticals Research Group, School of Biomedical Sciences, University of Newcastle, Newcastle, NSW, Australia
Br J Nutr 101:533-40. 2009..EPA and AA did not change the release of inflammatory biomarkers significantly. It is concluded that DHA has a potential role in suppressing RV-induced airway inflammation... - Validity of the common cold questionnaire (CCQ) in asthma exacerbationsHeather Powell
Department of Respiratory and Sleep Medicine, Hunter Medical Research Institute, John Hunter Hospital, New Lambton, New South Wales, Australia
PLoS ONE 3:e1802. 2008..Its usefulness in people with acute asthma is unknown. Our aim was to assess the ability of the CCQ to detect viral infection and to monitor recovery during a viral induced asthma exacerbation and confirmed by virological testing...