Tien Wong

Summary

Affiliation: University of Melbourne
Country: Australia

Publications

  1. ncbi request reprint The eye in hypertension
    Tien Yin Wong
    Centre for Eye Research Australia, University of Melbourne, Australia
    Lancet 369:425-35. 2007
  2. pmc Diabetic retinopathy is related to both endothelium-dependent and -independent responses of skin microvascular flow
    Thanh T Nguyen
    Centre for Eye Research Australia, Royal Victorian University of Melbourne, Melbourne, Australia
    Diabetes Care 34:1389-93. 2011
  3. pmc Alterations in retinal microvascular geometry in young type 1 diabetes
    Muhammad Bayu Sasongko
    Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, University of Melbourne, Melbourne, Australia
    Diabetes Care 33:1331-6. 2010
  4. pmc Inflammatory, hemostatic, and other novel biomarkers for diabetic retinopathy: the multi-ethnic study of atherosclerosis
    Thanh T Nguyen
    Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, University of Melbourne, Melbourne, Australia
    Diabetes Care 32:1704-9. 2009
  5. pmc Flicker light-induced retinal vasodilation in diabetes and diabetic retinopathy
    Thanh T Nguyen
    Centre for Eye Research Australia, University of Melbourne, Melbourne, Victoria, Australia
    Diabetes Care 32:2075-80. 2009
  6. pmc The relationship between retinal vessel calibre and knee cartilage and BMLs
    Miranda L Davies-Tuck
    Department of Epidemiology and Preventive Medicine, Monash University, Central and Eastern Clinical School, Alfred Hospital, Melbourne, Vic, 3004, Australia
    BMC Musculoskelet Disord 13:255. 2012
  7. pmc Retinal microvascular signs and risk of stroke: the Multi-Ethnic Study of Atherosclerosis (MESA)
    Ryo Kawasaki
    Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, University of Melbourne, 32 Gisborne St, Melbourne, VIC3002 Australia
    Stroke 43:3245-51. 2012
  8. pmc Clinical risk factors for age-related macular degeneration: a systematic review and meta-analysis
    Usha Chakravarthy
    Centre for Vision Science, Queen s University Belfast, Northern Ireland, UK
    BMC Ophthalmol 10:31. 2010
  9. pmc Retinal vascular caliber, cardiovascular risk factors, and inflammation: the multi-ethnic study of atherosclerosis (MESA)
    Tien Yin Wong
    Centre for Eye Research Australia, University of Melbourne, Melbourne, Australia
    Invest Ophthalmol Vis Sci 47:2341-50. 2006
  10. ncbi request reprint Age-related macular degeneration and risk for stroke
    Tien Yin Wong
    Centre for Eye Research Australia, University of Melbourne, East Melbourne, Victoria, Australia
    Ann Intern Med 145:98-106. 2006

Research Grants

Collaborators

Detail Information

Publications89

  1. ncbi request reprint The eye in hypertension
    Tien Yin Wong
    Centre for Eye Research Australia, University of Melbourne, Australia
    Lancet 369:425-35. 2007
    ..Recognition of the ocular effects of blood pressure could allow physicians to better manage patients with hypertension, and to monitor its end-organ effects...
  2. pmc Diabetic retinopathy is related to both endothelium-dependent and -independent responses of skin microvascular flow
    Thanh T Nguyen
    Centre for Eye Research Australia, Royal Victorian University of Melbourne, Melbourne, Australia
    Diabetes Care 34:1389-93. 2011
    ..We examined the relationship of DR to endothelium-dependent and endothelium-independent responses in skin microvascular flow...
  3. pmc Alterations in retinal microvascular geometry in young type 1 diabetes
    Muhammad Bayu Sasongko
    Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, University of Melbourne, Melbourne, Australia
    Diabetes Care 33:1331-6. 2010
    ..To describe retinal microvascular geometric parameters in young patients with type 1 diabetes...
  4. pmc Inflammatory, hemostatic, and other novel biomarkers for diabetic retinopathy: the multi-ethnic study of atherosclerosis
    Thanh T Nguyen
    Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, University of Melbourne, Melbourne, Australia
    Diabetes Care 32:1704-9. 2009
    ..There are conflicting data regarding relationships of systemic biomarkers of inflammation, hemostasis, and homocysteine with diabetic retinopathy. We examined these relationships in the Multi-Ethnic Study of Atherosclerosis...
  5. pmc Flicker light-induced retinal vasodilation in diabetes and diabetic retinopathy
    Thanh T Nguyen
    Centre for Eye Research Australia, University of Melbourne, Melbourne, Victoria, Australia
    Diabetes Care 32:2075-80. 2009
    ..Flicker light-induced retinal vasodilation may reflect endothelial function in the retinal circulation. We investigated flicker light-induced vasodilation in individuals with diabetes and diabetic retinopathy...
  6. pmc The relationship between retinal vessel calibre and knee cartilage and BMLs
    Miranda L Davies-Tuck
    Department of Epidemiology and Preventive Medicine, Monash University, Central and Eastern Clinical School, Alfred Hospital, Melbourne, Vic, 3004, Australia
    BMC Musculoskelet Disord 13:255. 2012
    ....
  7. pmc Retinal microvascular signs and risk of stroke: the Multi-Ethnic Study of Atherosclerosis (MESA)
    Ryo Kawasaki
    Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, University of Melbourne, 32 Gisborne St, Melbourne, VIC3002 Australia
    Stroke 43:3245-51. 2012
    ..Small-vessel disease contributes to the pathophysiology of stroke, and retinal microvascular signs have been linked to the risk of stroke. We examined the relationship of retinal signs with incident stroke in a multiethnic cohort...
  8. pmc Clinical risk factors for age-related macular degeneration: a systematic review and meta-analysis
    Usha Chakravarthy
    Centre for Vision Science, Queen s University Belfast, Northern Ireland, UK
    BMC Ophthalmol 10:31. 2010
    ..We aimed to identify those risk factors with strong levels of evidence which could be easily assessed by physicians or ophthalmologists to implement preventive interventions or address current behaviours...
  9. pmc Retinal vascular caliber, cardiovascular risk factors, and inflammation: the multi-ethnic study of atherosclerosis (MESA)
    Tien Yin Wong
    Centre for Eye Research Australia, University of Melbourne, Melbourne, Australia
    Invest Ophthalmol Vis Sci 47:2341-50. 2006
    ..To describe the relationship of retinal arteriolar and venular caliber with cardiovascular risk factors, including inflammatory biomarkers, in a multiethnic population of whites, blacks, Hispanics, and Chinese...
  10. ncbi request reprint Age-related macular degeneration and risk for stroke
    Tien Yin Wong
    Centre for Eye Research Australia, University of Melbourne, East Melbourne, Victoria, Australia
    Ann Intern Med 145:98-106. 2006
    ..Age-related macular degeneration (AMD) affects 7 million persons 40 years of age and older in the United States. Risk factors for the disease are similar to those for stroke...
  11. ncbi request reprint Fred Hollows lecture: hypertensive retinopathy - a journey from fundoscopy to digital imaging
    Tien Y Wong
    Retinal Vascular Imaging Centre, Centre for Eye Research Australia, University of Melbourne, East Melbourne, Victoria, Australia
    Clin Experiment Ophthalmol 34:397-400. 2006
    ..Future advances in digital retinal imaging technology will allow researchers and clinicians to better chart and monitor the vascular effects of hypertension...
  12. ncbi request reprint Quantitative retinal venular caliber and risk of cardiovascular disease in older persons: the cardiovascular health study
    Tien Yin Wong
    Centre for Eye Research Australia, University of Melbourne, Victoria, Australia
    Arch Intern Med 166:2388-94. 2006
    ..Small vessel disease may contribute to the risk of cardiovascular disease in older persons. We describe the relation of retinal vascular caliber to incident coronary heart disease (CHD) and stroke in elderly persons...
  13. pmc Relation between fasting glucose and retinopathy for diagnosis of diabetes: three population-based cross-sectional studies
    Tien Y Wong
    Centre for Eye Research Australia, University of Melbourne, Vic, Australia
    Lancet 371:736-43. 2008
    ..We aimed to provide updated data for the relation between fasting plasma glucose (FPG) and retinopathy, and to assess the diagnostic accuracy of current FPG thresholds in identifying both prevalent and incident retinopathy...
  14. ncbi request reprint Is peripheral neuropathy associated with retinopathy and albuminuria in individuals with impaired glucose metabolism? The 1999-2000 AusDiab
    Elizabeth L M Barr
    Centre for Eye Research Australia, University of Melbourne, 32 Gisborne St, Victoria 3002, Australia
    Diabetes Care 29:1114-6. 2006
  15. pmc The epidemiology of age related eye diseases in Asia
    T Y Wong
    Centre for Eye Research Australia, University of Melbourne, 32 Gisborne Street, Victoria 3002, Australia
    Br J Ophthalmol 90:506-11. 2006
    ..In contrast, there are few well conducted population based studies on diabetic retinopathy and age related macular degeneration in Asia, two conditions that are likely to be important causes of blindness in the future...
  16. pmc Diabetic retinopathy in a multi-ethnic cohort in the United States
    Tien Yin Wong
    Centre for Eye Research Australia, University of Melbourne, 32 Gisborne Street, Melbourne, Victoria 3002, Australia
    Am J Ophthalmol 141:446-455. 2006
    ..To describe the prevalence and risk factors of diabetic retinopathy in a multi-ethnic US population of whites, blacks, hispanics, and chinese...
  17. pmc Do retinopathy signs in non-diabetic individuals predict the subsequent risk of diabetes?
    T Y Wong
    Retinal Vascular Imaging Centre, Centre for Eye Research Australia, Univeristy of Melbourne, 32 Gisborne Street, VIC 3002, Australia
    Br J Ophthalmol 90:301-3. 2006
    ..In a cohort of people without diabetes, the association of these retinopathy signs and subsequent development of diabetes were examined...
  18. ncbi request reprint Age-related macular degeneration and risk of coronary heart disease: the Atherosclerosis Risk in Communities Study
    Tien Yin Wong
    Centre for Eye Research Australia, University of Melbourne, Melbourne, Australia
    Ophthalmology 114:86-91. 2007
    ..To examine the association of age-related macular degeneration (AMD) with incident coronary heart disease (CHD) and all-cause mortality...
  19. pmc Three-year incidence and cumulative prevalence of retinopathy: the atherosclerosis risk in communities study
    Tien Y Wong
    Centre for Eye Research Australia, University of Melbourne, Victoria, Australia
    Am J Ophthalmol 143:970-6. 2007
    ..To describe the three-year incidence and cumulative prevalence of retinopathy and its risk factors...
  20. pmc Rates of progression in diabetic retinopathy during different time periods: a systematic review and meta-analysis
    Tien Y Wong
    Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Australia
    Diabetes Care 32:2307-13. 2009
    ..This meta-analysis reviews rates of progression of diabetic retinopathy to proliferative diabetic retinopathy (PDR) and/or severe visual loss (SVL) and temporal trends...
  21. doi request reprint Effect of blood pressure on the retinal vasculature in a multi-ethnic Asian population
    V Swetha E Jeganathan
    Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Victoria, Australia
    Hypertens Res 32:975-82. 2009
    ..0001); furthermore, the magnitude of this effect was similar across the three racial/ethnic groups. The effect of blood pressure on the retinal vasculature was similar across three major racial/ethnic groups in Asia...
  22. doi request reprint Population-based studies in ophthalmology
    Tien Y Wong
    Centre for Eye Research Australia, University of Melbourne, Melbourne, Australia
    Am J Ophthalmol 146:656-63. 2008
    ..To review major findings of population-based studies in ophthalmology, to summarize key questions, and to highlight future directions for this study design...
  23. doi request reprint Prevalence and causes of low vision and blindness in an urban malay population: the Singapore Malay Eye Study
    Tien Yin Wong
    Centre for Eye Research Australia, The University of Melbourne, 32 Gisborne St, Melbourne 3002, Victoria, Australia
    Arch Ophthalmol 126:1091-9. 2008
    ..To describe the prevalence and causes of low vision and blindness in a Malay population...
  24. ncbi request reprint Is depression associated with microvascular disease in patients with type 2 diabetes?
    Thanh Tan Nguyen
    Centre for Eye Research Australia, University of Melbourne, Melbourne, Victoria, Australia
    Depress Anxiety 25:E158-62. 2008
    ..Studies with larger sample size may provide further insights into this association...
  25. pmc Dietary antioxidants and primary prevention of age related macular degeneration: systematic review and meta-analysis
    Elaine W T Chong
    Centre for Eye Research Australia, University of Melbourne, Victoria 3002, Australia
    BMJ 335:755. 2007
    ..To evaluate the effectiveness of dietary antioxidants in the primary prevention of age related macular degeneration (AMD)...
  26. ncbi request reprint Relation of retinopathy to coronary artery calcification: the multi-ethnic study of atherosclerosis
    Tien Y Wong
    Centre for Eye Research Australia, Department of Ophthalmology, School of Medicine, University of Melbourne, Australia
    Am J Epidemiol 167:51-8. 2008
    ..This study shows that retinopathy signs are independently associated with CAC, supporting the concept that common pathophysiologic processes may underlie both micro- and macrovascular disease...
  27. ncbi request reprint Clinical update: new treatments for age-related macular degeneration
    Tien Y Wong
    Centre for Eye Research, University of Melbourne, Melbourne 3002, Victoria, Australia
    Lancet 370:204-6. 2007
  28. ncbi request reprint Apolipoprotein E gene and early age-related maculopathy: the Atherosclerosis Risk in Communities Study
    Tien Yin Wong
    Centre for Eye Research Australia, University of Melbourne, Melbourne, Victoria, Australia
    Ophthalmology 113:255-9. 2006
    ..To examine the association between the apolipoprotein E (APOE) gene and early age-related maculopathy (ARM) in middle-aged persons...
  29. ncbi request reprint Retinopathy in persons with impaired glucose metabolism: the Australian Diabetes Obesity and Lifestyle (AusDiab) study
    Tien Y Wong
    Centre for Eye Research Australia, University of Melbourne, 32 Gisborne Street, Melbourne, Victoria 3002, Australia
    Am J Ophthalmol 140:1157-9. 2005
    ..To describe risk factors and vascular disease associations of retinopathy in people with impaired glucose metabolism...
  30. ncbi request reprint Retinal microvascular abnormalities and renal dysfunction: the atherosclerosis risk in communities study
    Tien Yin Wong
    Centre for Eye Research Australia, University of Melbourne, 32 Gisborne Street, Victoria 3002, Australia
    J Am Soc Nephrol 15:2469-76. 2004
    ..Retinal microvascular abnormalities are associated with renal dysfunction, suggesting that common systemic microvascular processes may underlie the development of microvascular damage in the eye and kidneys...
  31. ncbi request reprint Hypertensive retinopathy
    Tien Y Wong
    Centre for Eye Research Australia, University of Melbourne, East Melbourne, Australia
    N Engl J Med 351:2310-7. 2004
  32. ncbi request reprint Retinal arteriolar narrowing, hypertension, and subsequent risk of diabetes mellitus
    Tien Yin Wong
    Centre for Eye Research Australia, University of Melbourne, Melbourne, Victoria
    Arch Intern Med 165:1060-5. 2005
    ..Microvascular disease and hypertension have been linked with risk of diabetes mellitus. We examined the association of retinal arteriolar narrowing, a marker of chronic hypertension, with incident diabetes...
  33. pmc Prospective cohort study of retinal vessel diameters and risk of hypertension
    Tien Yin Wong
    Centre for Eye Research Australia, University of Melbourne, Victoria 3002, Australia
    BMJ 329:79. 2004
    ..To examine the relation between diameters of the retinal arterioles and 10 year incidence of hypertension...
  34. ncbi request reprint Hypertensive retinopathy signs as risk indicators of cardiovascular morbidity and mortality
    Tien Yin Wong
    Centre for Eye Research Australia, University of Melbourne, 32 Gisborne Street, East Melbourne 3002, Australia
    Br Med Bull 73:57-70. 2005
    ..These data support the concept that an assessment of retinal vascular changes may provide further information for vascular risk stratification in persons with hypertension...
  35. ncbi request reprint The natural history and prognosis of neovascular age-related macular degeneration: a systematic review of the literature and meta-analysis
    Tien Y Wong
    Centre for Eye Research Australia, University of Melbourne, Melbourne, Australia
    Ophthalmology 115:116-26. 2008
    ..To describe the natural history and progression of visual loss in eyes with untreated neovascular age-related macular degeneration (AMD)...
  36. ncbi request reprint Prevalence of cataract surgery and post-surgical visual outcomes in an urban Asian population: the Singapore Malay Eye Study
    R Lavanya
    Centre for Eye Research Australia, University of Melbourne, 32 Gisborne Street, East Melbourne, VIC 3002 Australia
    Br J Ophthalmol 93:299-304. 2009
    ..The aim of the study was to describe the prevalence and visual outcomes of cataract surgery in an urban Asian population...
  37. ncbi request reprint The relationship of retinal vascular calibre to diabetes and retinopathy: the Australian Diabetes, Obesity and Lifestyle (AusDiab) study
    G Tikellis
    Centre for Eye Research Australia, University of Melbourne, 32 Gisborne Street, East Melbourne 3002, Vic, Australia
    Diabetologia 50:2263-71. 2007
    ..The aim of the study was to examine the relationship of retinal vascular calibre with glucose intolerance, diabetes and retinopathy in a population-based cohort...
  38. doi request reprint Plasminogen activator inhibitor-1 (PAI-1) activity and retinal vascular calibre in type 2 diabetes
    L Brazionis
    Department of Medicine, University of Melbourne, St Vincent s Hospital, Australia
    Diabetes Res Clin Pract 87:192-9. 2010
    ..To describe relationships of retinal vascular calibre with plasminogen activator inhibitor-1 (PAI-1) and other cardiovascular risk factors in people with type 2 diabetes...
  39. doi request reprint Birth weight is not related to risk of diabetic retinopathy in type 2 diabetes: the Atherosclerosis Risk in Communities Study
    G Liew
    Department of Ophthalmology, University of Sydney, Centre for Vision Research, Westmead Hospital, Westmead Millennium Institute, Australia
    Curr Eye Res 33:193-8. 2008
    ..Low birth weight has been suggested as a risk factor for diabetes. Whether it is related to diabetic retinopathy is unclear and is examined in this study...
  40. doi request reprint Prevalence and causes of decreased visual acuity in Singaporean Chinese preschoolers
    M Dirani
    Singapore Eye Research Institute, Singapore, Singapore
    Br J Ophthalmol 94:1561-5. 2010
    ..To describe the prevalence and causes of decreased visual acuity (VA) in Singaporean Chinese children...
  41. doi request reprint Racial difference in the prevalence of epiretinal membrane between Caucasians and Asians
    R Kawasaki
    Centre for Eye Research Australia, University of Melbourne, Australia
    Br J Ophthalmol 92:1320-4. 2008
    ..To describe the prevalence and risk factors of epiretinal membranes (ERM) in Asian Malays and to compare this with a white population...
  42. doi request reprint Blood pressure control and awareness among patients with diabetes and hypertension attending a tertiary ophthalmic clinic
    N Wong
    Centre for Eye Research Australia, University of Melbourne, Melbourne, Australia
    Diabet Med 26:34-9. 2009
    ..To assess the proportion of patients who had diabetes and hypertension with optimal blood pressure (BP) control and to describe patients' awareness of the importance of BP control...
  43. pmc Retinal vessel wall signs and the 5 year incidence of age related maculopathy: the Blue Mountains Eye Study
    J J Wang
    Centre for Vision Research, Department of Ophthalmology, University of Sydney, Westmead Hospital, Hawkesbury Road, Westmead, NSW 2145, Australia
    Br J Ophthalmol 88:104-9. 2004
    ..To assess whether retinal arteriolar wall changes (focal narrowing and arteriovenous nicking) are associated with an increased 5 year risk of age related maculopathy (ARM)...
  44. pmc Retinal vascular calibre and the risk of coronary heart disease-related death
    J J Wang
    Centre for Vision Research, Department of Ophthalmology, Westmead Millennium Institute, University of Sydney, Sydney, Australia
    Heart 92:1583-7. 2006
    ..To examine whether retinal vascular calibre independently predicts risk of coronary heart disease (CHD) -related death...
  45. ncbi request reprint Body mass index and its effects on retinal vessel diameter in 6-year-old children
    B Taylor
    Centre for Vision Research, Department of Ophthalmology, Westmead Millennium Institute, Westmead Hospital, University of Sydney, Sydney, New South Wales 2145, Australia
    Int J Obes (Lond) 31:1527-33. 2007
    ..To examine the relationship between body mass index (BMI) and other anthropometric measures with retinal vessel diameter in children...
  46. ncbi request reprint Retinal fractal dimension is increased in persons with diabetes but not impaired glucose metabolism: the Australian Diabetes, Obesity and Lifestyle (AusDiab) study
    J W Y Yau
    Centre for Eye Research Australia, University of Melbourne, East Melbourne, Vic, Australia
    Diabetologia 53:2042-5. 2010
    ..The fractal dimension (D(f)) of the retinal vasculature is a global measure of its branching pattern complexity. We examined the relationship of retinal D(f) with diabetes...
  47. doi request reprint Prevalence and risk factors of retinal vein occlusion in an Asian population
    L L Lim
    Centre for Eye Research Australia, University of Melbourne, Australia
    Br J Ophthalmol 92:1316-9. 2008
    ..To describe the prevalence and risk factors of retinal vein occlusion (RVO) in an Asian population...
  48. pmc Hypertension genes and retinal vascular calibre: the Cardiovascular Health Study
    C Sun
    Centre for Eye Research Australia, University of Melbourne, Victoria, Australia
    J Hum Hypertens 23:578-84. 2009
    ..2 vs 167.7 microm). In conclusion, this study found no evidence of an association of SNPs in candidate hypertension genes studied here with retinal vascular calibre...
  49. ncbi request reprint Retinal microvascular signs and risk of stroke and stroke mortality
    P Mitchell
    Centre for Vision Research, Department of Ophthalmology, Westmead Millennium and Save Sight Institutes, University of Sydney, Australia
    Neurology 65:1005-9. 2005
    ..The purpose of this study was to assess the relation of retinal microvascular signs and incident stroke and stroke mortality in an older population...
  50. doi request reprint Retinopathy predicts coronary heart disease mortality
    G Liew
    Department of Ophthalmology, Centre for Vision Research, University of Sydney, Westmead Hospital, Westmead, NSW, Australia
    Heart 95:391-4. 2009
    ..Retinopathy lesions are fairly common findings in clinic settings and may predict risk of coronary heart disease (CHD)...
  51. doi request reprint Prevalence and risk factors for refractive errors in the Singapore Malay Eye Survey
    Seang Mei Saw
    Department of Community, Occupational and Family Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    Ophthalmology 115:1713-9. 2008
    ..To describe the prevalence and risk factors for myopia and other refractive errors in an urban Malay population in Singapore...
  52. ncbi request reprint Retinal microvascular abnormalities and 10-year cardiovascular mortality: a population-based case-control study
    Tien Yin Wong
    Singapore National Eye Center and National University of Singapore, Singapore, Republic of Singapore
    Ophthalmology 110:933-40. 2003
    ..Retinal microvascular abnormalities reflect persistent arteriolar damage from hypertension and independently predict stroke. We examined their associations with long-term cardiovascular mortality...
  53. ncbi request reprint The prevalence and risk factors of retinal microvascular abnormalities in older persons: The Cardiovascular Health Study
    Tien Yin Wong
    Singapore Eye Research Institute, Singapore, Republic of Singapore
    Ophthalmology 110:658-66. 2003
    ..To describe the prevalence of retinal microvascular characteristics and their associations with atherosclerosis in elderly, nondiabetic persons...
  54. pmc Traditional and novel cardiovascular risk factors for retinal vein occlusion: the multiethnic study of atherosclerosis
    Ning Cheung
    Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, University of Melbourne, East Melbourne, Victoria, Australia
    Invest Ophthalmol Vis Sci 49:4297-302. 2008
    ..To describe the prevalence of retinal vein occlusion (RVO) and its association with cardiovascular, inflammatory, and hematologic risk factors in a multiethnic cohort...
  55. ncbi request reprint Hypertensive retinal vessel wall signs in a general older population: the Blue Mountains Eye Study
    Jie Jin Wang
    Centre for Vision Research, Department of Ophthalmology and the Westmead Millennium and Save Sight Institutes, The University of Sydney, Westmead, NSW, Australia, 2145
    Hypertension 42:534-41. 2003
    ..3 (0.9 to 1.8), 2.3 (1.6 to 3.2), and 1.9 (1.3 to 2.7), respectively. Our findings demonstrate a strong relation between presence and severity of hypertension and retinal microvascular structural changes...
  56. ncbi request reprint Reliability of retinal photography in the assessment of retinal microvascular characteristics: the Atherosclerosis Risk in Communities Study
    David J Couper
    Department of Biostatistics, University of North Carolina, Chapel Hill, North Carolina 27514, USA
    Am J Ophthalmol 133:78-88. 2002
    ..Retinal microvascular characteristics, as graded from retinal photography, have been shown to predict stroke. We evaluated the reliability of retinal photographic grading in the Atherosclerosis Risk in Communities Study...
  57. ncbi request reprint Retinal arteriolar narrowing and risk of coronary heart disease in men and women. The Atherosclerosis Risk in Communities Study
    Tien Yin Wong
    Department of Ophthalmology, National University of Singapore, 10 Kent Ridge Crescent, Singapore 119260
    JAMA 287:1153-9. 2002
    ..Microvascular processes have been hypothesized to play a greater role in the development of coronary heart disease (CHD) in women than in men; however, prospective clinical data are limited...
  58. ncbi request reprint Retinal arteriolar emboli: epidemiology and risk of stroke
    Tien Yin Wong
    Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, Wisconsin, USA
    Curr Opin Ophthalmol 13:142-6. 2002
    ..Whether carotid ultrasound and other vascular imaging studies should be performed routinely for all patients with asymptomatic retinal emboli remains uncertain...
  59. ncbi request reprint Retinal arteriolar narrowing and risk of diabetes mellitus in middle-aged persons
    Tien Yin Wong
    Department of Ophthalmology, National University of Singapore, 10 Kent Ridge Crescent, Singapore 119260
    JAMA 287:2528-33. 2002
    ..Microvascular processes have been hypothesized to play a role in the pathogenesis of type 2 diabetes mellitus, but prospective clinical data regarding this hypothesis are unavailable...
  60. ncbi request reprint Retinal microvascular abnormalities and cognitive impairment in middle-aged persons: the Atherosclerosis Risk in Communities Study
    Tien Yin Wong
    Department of Ophthalmology, University of Wisconsin, Madison, USA
    Stroke 33:1487-92. 2002
    ..Here, we examine the relation of retinal microvascular abnormalities with cognitive function in middle-aged persons free of stroke...
  61. ncbi request reprint Refractive errors, axial ocular dimensions, and age-related cataracts: the Tanjong Pagar survey
    Tien Yin Wong
    Department of Ophthalmology, National University of Singapore, Singapore
    Invest Ophthalmol Vis Sci 44:1479-85. 2003
    ..To describe the relationship of refractive errors and axial ocular dimensions and age-related cataract...
  62. ncbi request reprint Cerebral white matter lesions, retinopathy, and incident clinical stroke
    Tien Yin Wong
    Department of Ophthalmology, University of Wisconsin, Madison, USA
    JAMA 288:67-74. 2002
    ..White matter lesions (WMLs) detected on cerebral imaging scans have been hypothesized to have a microvascular etiology and to precede the development of clinical stroke. However, few clinical data are available to support these hypotheses...
  63. ncbi request reprint Prevalence of lens opacity in Chinese residents of Singapore: the tanjong pagar survey
    Steve K L Seah
    Singapore National Eye Centre, Singapore
    Ophthalmology 109:2058-64. 2002
    ..To determine the prevalence of lens opacity among Chinese residents of Singapore...
  64. ncbi request reprint Racial differences in the prevalence of hypertensive retinopathy
    Tien Yin Wong
    Department of Ophthalmology, Singapore National Eye Center and National University of Singapore
    Hypertension 41:1086-91. 2003
    ....
  65. ncbi request reprint Retinal arteriolar narrowing and left ventricular remodeling: the multi-ethnic study of atherosclerosis
    Ning Cheung
    Centre for Eye Research Australia, University of Melbourne, Victoria, Australia
    J Am Coll Cardiol 50:48-55. 2007
    ..This study sought to examine the relationships of retinal vascular signs with left ventricular (LV) mass, volume, and concentric remodeling...
  66. doi request reprint Retinal arteriolar caliber predicts incident retinopathy: the Australian Diabetes, Obesity and Lifestyle (AusDiab) study
    Sophie Louise Rogers
    Centre for Eye Research, University of Melbourne, 32 Gisborne St, Victoria 3002, Australia
    Diabetes Care 31:761-3. 2008
    ..Venular caliber did not predict incident retinopathy. Our findings suggest that retinal arteriolar dilatation is a specific sign of diabetic microvascular dysfunction and may be a preclinical marker of diabetic retinopathy...
  67. ncbi request reprint Computer-assisted measurement of retinal vessel diameters in the Beaver Dam Eye Study: methodology, correlation between eyes, and effect of refractive errors
    Tien Yin Wong
    Department of Ophthalmology, University of Wisconsin, Madison, Wisconsin, USA
    Ophthalmology 111:1183-90. 2004
    ....
  68. ncbi request reprint BMI and retinal vascular caliber in children
    Ning Cheung
    Centre for Eye Research Australia, University of Melbourne, 32 Gisborne Street, Victoria 3002, Australia
    Obesity (Silver Spring) 15:209-15. 2007
    ..In adult populations, changes in retinal vascular caliber have been linked with obesity and metabolic syndrome. We examined the association of BMI and weight with retinal vascular caliber in children...
  69. ncbi request reprint Does refractive error influence the association of blood pressure and retinal vessel diameters? The Blue Mountains Eye Study
    Tien Yin Wong
    Centre for Eye Research Australia, University of Melbourne, East Melbourne
    Am J Ophthalmol 137:1050-5. 2004
    ..To determine if refractive errors influence the association of blood pressure and retinal vessel diameters...
  70. ncbi request reprint Measurement of retinal vascular caliber: issues and alternatives to using the arteriole to venule ratio
    Gerald Liew
    Centre for Vision Research, Department of Ophthalmology, Westmead Millennium Instiute, University of Sydney, Sydney, Australia
    Invest Ophthalmol Vis Sci 48:52-7. 2007
    ....
  71. ncbi request reprint Associations between the metabolic syndrome and retinal microvascular signs: the Atherosclerosis Risk In Communities study
    Tien Yin Wong
    Centre for Eye Research Australia, University of Melbourne, Melbourne, Victoria, Australia
    Invest Ophthalmol Vis Sci 45:2949-54. 2004
    ..To examine the cross-sectional relationship of the metabolic syndrome (hypertension, hyperglycemia, central obesity, and dyslipidemia) and retinal microvascular abnormalities in middle-aged men and women...
  72. ncbi request reprint Cardiovascular risk factors and retinal microvascular signs in an adult Japanese population: the Funagata Study
    Ryo Kawasaki
    Centre for Vision Research, Westmead Millennium Institute, University of Sydney, Sydney, Australia
    Ophthalmology 113:1378-84. 2006
    ..To describe the prevalence of retinal vascular signs and their association with cardiovascular risk factors in a Japanese population...
  73. ncbi request reprint Are narrower or wider retinal venules associated with incident hypertension?
    Gerald Liew
    Hypertension 48:e10; author reply e11. 2006
  74. ncbi request reprint Regular aspirin use and retinal microvascular signs: the Blue Mountains Eye Study
    Gerald Liew
    Centre for Vision Research, Department of Ophthalmology Westmead Hospital, The Westmead Millennium Institute, University of Sydney, Australia
    J Hypertens 24:1329-35. 2006
    ..The effect of aspirin on the microvasculature has not been well studied. We examined the cross-sectional and longitudinal associations between regular aspirin use and retinal microvascular signs...
  75. ncbi request reprint Cardiovascular risk factors for retinal vein occlusion and arteriolar emboli: the Atherosclerosis Risk in Communities & Cardiovascular Health studies
    Tien Yin Wong
    Centre for Eye Research Australia, University of Melbourne, Melbourne, Australia
    Ophthalmology 112:540-7. 2005
    ..To examine the associations of retinal vein occlusion and arteriolar emboli with cardiovascular disease...
  76. ncbi request reprint Systemic associations of retinal microvascular signs: a review of recent population-based studies
    Tien Yin Wong
    Centre for Eye Research Australia, University of Melbourne
    Ophthalmic Physiol Opt 25:195-204. 2005
    ....
  77. ncbi request reprint Distribution and associations of retinal vascular caliber with ethnicity, gender, and birth parameters in young children
    Ning Cheung
    Centre for Eye Research Australia, University of Melbourne, Melbourne, Victoria, Australia
    Invest Ophthalmol Vis Sci 48:1018-24. 2007
    ..To describe the distribution of retinal vascular calibers and their associations with ethnicity, gender, and birth parameters in children...
  78. ncbi request reprint Subclinical atherosclerotic cardiovascular disease and early age-related macular degeneration in a multiracial cohort: the Multiethnic Study of Atherosclerosis
    Ronald Klein
    Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison 53726 2397, USA
    Arch Ophthalmol 125:534-43. 2007
    ..To investigate the relationship of subclinical atherosclerotic cardiovascular disease (CVD) and its risk factors with age-related macular degeneration (AMD) in the Multiethnic Study of Atherosclerosis...
  79. ncbi request reprint Association between body mass index and chronic kidney disease in men and women: population-based study of Malay adults in Singapore
    Anoop Shankar
    Department of Community, Occupational, and Family Medicine, Singapore General Hospital, Singapore
    Nephrol Dial Transplant 23:1910-8. 2008
    ..In this context, we examined the relationship between BMI and CKD, by gender, in a study of Malay adults from Singapore...
  80. ncbi request reprint Relationship of retinal vascular caliber with diabetes and retinopathy: the Multi-Ethnic Study of Atherosclerosis (MESA)
    Thanh Tan Nguyen
    Centre for Eye Research Australia, University of Melbourne, 32 Gisborne Street, Victoria 3002, Australia
    Diabetes Care 31:544-9. 2008
    ..To examine the relationship of retinal vascular caliber with diabetes, glycemia, and diabetic retinopathy...
  81. ncbi request reprint Revised formulas for summarizing retinal vessel diameters
    Michael D Knudtson
    Department of Ophthalmology, University of Wisconsin, Madison, WI 53726, USA
    Curr Eye Res 27:143-9. 2003
    ....
  82. ncbi request reprint Relationship of retinal vascular caliber with optic disc diameter in children
    Ning Cheung
    Centre for Eye Research Australia, University of Melbourne, Victoria, Australia
    Invest Ophthalmol Vis Sci 48:4945-8. 2007
    ..To describe the relationships of retinal vascular caliber to optic disc diameter in children...
  83. ncbi request reprint Retinal vessel diameters and their associations with age and blood pressure
    Tien Yin Wong
    Centre for Eye Research Australia, University of Melbourne, East Melbourne, Victoria, Australia
    Invest Ophthalmol Vis Sci 44:4644-50. 2003
    ..To describe the cross-sectional relationship between retinal arteriolar and venular diameters with age and blood pressure...
  84. ncbi request reprint Retinal arteriolar emboli and long-term mortality: pooled data analysis from two older populations
    Jie Jin Wang
    University of Sydney Department of Ophthalmology, Centre for Vision Research, Westmead Hospital, The Westmead Millennium Institute, NSW, Australia
    Stroke 37:1833-6. 2006
    ..To assess the relationship between retinal arteriolar emboli and mortality in older people...
  85. ncbi request reprint Relationship of axial length and retinal vascular caliber in children
    Ning Cheung
    Centre for Eye Research Australia, University of Melbourne, Melbourne, Victoria, Australia
    Am J Ophthalmol 144:658-662. 2007
    ..In this study, we re-examined this relationship in a cohort of children, while controlling for the effects of ocular magnification...
  86. pmc Plasma sphingomyelin is not associated with microvascular changes in the retina
    Ning Cheung
    Microvasc Res 75:9. 2008
  87. ncbi request reprint A prospective cohort study of retinal arteriolar narrowing and mortality
    Tien Yin Wong
    Department of Ophthalmology, University of Melbourne, Victoria, Australia
    Am J Epidemiol 159:819-25. 2004
    ....
  88. ncbi request reprint Influence of intraocular pressure on retinal vascular caliber measurements in children
    Kristin de Haseth
    Centre for Eye Research Australia, University of Melbourne, Melbourne, Victoria, Australia
    Am J Ophthalmol 143:1040-2. 2007
    ..To determine whether intraocular pressure (IOP) influences retinal vascular caliber in young children, in order to provide a better understanding of its physiological determinants...
  89. ncbi request reprint Prevalence of age-related macular degeneration in 4 racial/ethnic groups in the multi-ethnic study of atherosclerosis
    Ronald Klein
    Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, Wisconsin 53726 2336, USA
    Ophthalmology 113:373-80. 2006
    ..To describe the prevalence of age-related macular degeneration (AMD) in 4 racial/ethnic groups (white, black, Hispanic, and Chinese) that participated in the second examination of the Multi-ethnic Study of Atherosclerosis (MESA)...

Research Grants1

  1. Retinal Microvascular Signs and CVD in Older Persons
    Tien Wong; Fiscal Year: 2005
    ..This may ultimately lead to improved identification, and preventive and therapeutic strategies for the most common causes of morbidity, disability and mortality affecting elderly people in the United States. ..