Leanne M Williams

Summary

Affiliation: University of Sydney
Country: Australia

Publications

  1. ncbi Rates of decline distinguish Alzheimer's disease and mild cognitive impairment relative to normal aging: integrating cognition and brain function
    Belinda J Liddell
    The Brain Resource International Database and the Brain Resource Company, NSW 2007, Australia
    J Integr Neurosci 6:141-74. 2007
  2. ncbi A polymorphism of the MAOA gene is associated with emotional brain markers and personality traits on an antisocial index
    Leanne M Williams
    The Brain Dynamics Centre, Westmead Millennium Institute, Westmead Hospital and Western Clinical School, University of Sydney, Westmead, NSW, Australia
    Neuropsychopharmacology 34:1797-809. 2009
  3. ncbi 'Negativity bias' in risk for depression and anxiety: brain-body fear circuitry correlates, 5-HTT-LPR and early life stress
    Leanne M Williams
    Brain Dynamics Centre, Westmead Millennium Institute and University of Sydney at Westmead Hospital, Westmead, NSW 2145, Australia
    Neuroimage 47:804-14. 2009
  4. ncbi Explicit identification and implicit recognition of facial emotions: I. Age effects in males and females across 10 decades
    Leanne M Williams
    Brain Dynamics Centre, Westmead Millennium Institute and Western Clinical School, University of Sydney, Westmead Hospital, Westmead, New South Wales, Australia
    J Clin Exp Neuropsychol 31:257-77. 2009
  5. ncbi Voxel-based morphometry in schizophrenia: implications for neurodevelopmental connectivity models, cognition and affect
    Leanne M Williams
    Brain Dynamics Centre, Westmead Millennium Institute and Western Clinical School, University of Sydney, Westmead Hospital, NSW 2145, Australia
    Expert Rev Neurother 8:1049-65. 2008
  6. ncbi Emotion-elicited gamma synchrony in patients with first-episode schizophrenia: a neural correlate of social cognition outcomes
    Leanne M Williams
    Brain Dynamics Centre, Westmead Millennium Institute and Western Clinical School, University of Sydney, Westmead Hospital, Westmead NSW, Australia
    J Psychiatry Neurosci 34:303-13. 2009
  7. ncbi Misinterpreting emotional expressions in attention-deficit/hyperactivity disorder: evidence for a neural marker and stimulant effects
    Leanne M Williams
    Brain Dynamics Centre and Clinics, Westmead Millennium Institute and Western Clinical School, University of Sydney, Westmead Hospital, New South Wales, Australia
    Biol Psychiatry 63:917-26. 2008
  8. ncbi Using brain-based cognitive measures to support clinical decisions in ADHD
    Leanne M Williams
    Brain Dynamics Center, Westmead Millennium Institute and University of Sydney at Westmead Hospital, Westmead, New South Wales, Australia
    Pediatr Neurol 42:118-26. 2010
  9. ncbi General and social cognition in first episode schizophrenia: identification of separable factors and prediction of functional outcome using the IntegNeuro test battery
    Leanne M Williams
    The Brain Dynamics Centre, Westmead Millennium Institute and Western Clinical School, University of Sydney, Westmead Hospital, NSW, 2145, Australia
    Schizophr Res 99:182-91. 2008
  10. ncbi The mellow years?: neural basis of improving emotional stability over age
    Leanne M Williams
    Brain Dynamics Centre, Westmead Millenium Institute and Western Clinical School, University of Sydney, Westmead Hospital, Westmead, Sydney, New South Wales, 2145, Australia
    J Neurosci 26:6422-30. 2006

Detail Information

Publications100

  1. ncbi Rates of decline distinguish Alzheimer's disease and mild cognitive impairment relative to normal aging: integrating cognition and brain function
    Belinda J Liddell
    The Brain Resource International Database and the Brain Resource Company, NSW 2007, Australia
    J Integr Neurosci 6:141-74. 2007
    ..Increasing age is the strongest risk factor for Alzheimer's disease (AD). Yet, departure from normal age-related decline for established markers of AD including memory, cognitive decline and brain function deficits, has not been quantified...
  2. ncbi A polymorphism of the MAOA gene is associated with emotional brain markers and personality traits on an antisocial index
    Leanne M Williams
    The Brain Dynamics Centre, Westmead Millennium Institute, Westmead Hospital and Western Clinical School, University of Sydney, Westmead, NSW, Australia
    Neuropsychopharmacology 34:1797-809. 2009
    ..Monoamines such as noradrenalin and serotonin may modulate these relationships, given that their metabolism varies according to MAOA variants, and that they modulate both emotional brain systems and antisocial aggression...
  3. ncbi 'Negativity bias' in risk for depression and anxiety: brain-body fear circuitry correlates, 5-HTT-LPR and early life stress
    Leanne M Williams
    Brain Dynamics Centre, Westmead Millennium Institute and University of Sydney at Westmead Hospital, Westmead, NSW 2145, Australia
    Neuroimage 47:804-14. 2009
    ..Given that negativity bias is a feature of conditions such as depression and associated biological alterations, the findings have implications for translation into clinical decision support...
  4. ncbi Explicit identification and implicit recognition of facial emotions: I. Age effects in males and females across 10 decades
    Leanne M Williams
    Brain Dynamics Centre, Westmead Millennium Institute and Western Clinical School, University of Sydney, Westmead Hospital, Westmead, New South Wales, Australia
    J Clin Exp Neuropsychol 31:257-77. 2009
    ..These findings provide a robust normative platform for assessing clinical groups...
  5. ncbi Voxel-based morphometry in schizophrenia: implications for neurodevelopmental connectivity models, cognition and affect
    Leanne M Williams
    Brain Dynamics Centre, Westmead Millennium Institute and Western Clinical School, University of Sydney, Westmead Hospital, NSW 2145, Australia
    Expert Rev Neurother 8:1049-65. 2008
    ..These findings are reviewed in relation to complementary evidence for neurodevelopmental deviation, and functional associations with both neuroimaging and behavioral measures of general and social cognition...
  6. ncbi Emotion-elicited gamma synchrony in patients with first-episode schizophrenia: a neural correlate of social cognition outcomes
    Leanne M Williams
    Brain Dynamics Centre, Westmead Millennium Institute and Western Clinical School, University of Sydney, Westmead Hospital, Westmead NSW, Australia
    J Psychiatry Neurosci 34:303-13. 2009
    ....
  7. ncbi Misinterpreting emotional expressions in attention-deficit/hyperactivity disorder: evidence for a neural marker and stimulant effects
    Leanne M Williams
    Brain Dynamics Centre and Clinics, Westmead Millennium Institute and Western Clinical School, University of Sydney, Westmead Hospital, New South Wales, Australia
    Biol Psychiatry 63:917-26. 2008
    ..We examined ADHD disturbances in mood and emotion recognition and underlying neural systems before and after treatment with stimulant medication...
  8. ncbi Using brain-based cognitive measures to support clinical decisions in ADHD
    Leanne M Williams
    Brain Dynamics Center, Westmead Millennium Institute and University of Sydney at Westmead Hospital, Westmead, New South Wales, Australia
    Pediatr Neurol 42:118-26. 2010
    ..quot; These markers offer a frame of reference to support diagnostic and treatment decisions, and an objective benchmark for monitoring outcomes of interventions...
  9. ncbi General and social cognition in first episode schizophrenia: identification of separable factors and prediction of functional outcome using the IntegNeuro test battery
    Leanne M Williams
    The Brain Dynamics Centre, Westmead Millennium Institute and Western Clinical School, University of Sydney, Westmead Hospital, NSW, 2145, Australia
    Schizophr Res 99:182-91. 2008
    ..We determined the presence of separable factors of general and social cognition, their equivalence to the consensus domains identified by the NIMH MATRICS project, and their effectiveness in predicting real world functional outcomes...
  10. ncbi The mellow years?: neural basis of improving emotional stability over age
    Leanne M Williams
    Brain Dynamics Centre, Westmead Millenium Institute and Western Clinical School, University of Sydney, Westmead Hospital, Westmead, Sydney, New South Wales, 2145, Australia
    J Neurosci 26:6422-30. 2006
    ....
  11. ncbi The 'when' and 'where' of perceiving signals of threat versus non-threat
    Leanne M Williams
    Brain Dynamics Centre, Westmead Millenium Institute and Western Clinical School, University of Sydney, Westmead Hospital, Australia
    Neuroimage 31:458-67. 2006
    ..While fear may be processed via parallel pathways (one initiated prior to structural encoding), neural systems supporting positively valenced input may be more localized and rely on structural encoding...
  12. ncbi Association between BDNF Val66Met polymorphism and trait depression is mediated via resting EEG alpha band activity
    Justine M Gatt
    The Brain Dynamics Centre, Westmead Millennium Institute, Westmead Hospital and Western Clinical School, University of Sydney, Sydney, Australia
    Biol Psychol 79:275-84. 2008
    ..They suggest that the BDNF Met/Met homozygote has a direct impact on memory systems, but impacts trait depression via the secondary effects of neural changes...
  13. ncbi Neural biases to covert and overt signals of fear: dissociation by trait anxiety and depression
    Leanne M Williams
    University of Sydney, Westmead Hospital, Sydney, NSW, Australia
    J Cogn Neurosci 19:1595-608. 2007
    ....
  14. ncbi Fronto-limbic and autonomic disjunctions to negative emotion distinguish schizophrenia subtypes
    Leanne M Williams
    Brain Dynamics Centre, Westmead Hospital, NSW, 2145, Australia
    Psychiatry Res 155:29-44. 2007
    ....
  15. ncbi Mapping frontal-limbic correlates of orienting to change detection
    Leanne M Williams
    The Brain Dynamics Centre, Westmead Millennium Institute and Western Clinical School, University of Sydney, Westmead Hospital, New South Wales, Sydney, Australia
    Neuroreport 18:197-202. 2007
    ....
  16. ncbi Heterogeneity of non-conscious fear perception in posttraumatic stress disorder as a function of physiological arousal: an fMRI study
    Andrew H Kemp
    School of Psychology, University of Sydney, Sydney, NSW, Australia
    Psychiatry Res 174:158-61. 2009
    ....
  17. ncbi Progressive grey matter atrophy over the first 2-3 years of illness in first-episode schizophrenia: a tensor-based morphometry study
    Thomas J Whitford
    The Brain Dynamics Centre, Westmead Millennium Institute and University of Sydney, Acacia House, Westmead Hospital, NSW 2145, Australia
    Neuroimage 32:511-9. 2006
    ..We argue that the progressive GM atrophy we have found to be associated with the onset of schizophrenia arises from a dysfunction in the dramatic period of healthy brain development typically associated with adolescence...
  18. ncbi Amygdala-prefrontal dissociation of subliminal and supraliminal fear
    Leanne M Williams
    Brain Dynamics Centre, Westmead Hospital, Westmead Sydney, NSW, Australia
    Hum Brain Mapp 27:652-61. 2006
    ....
  19. ncbi A direct brainstem-amygdala-cortical 'alarm' system for subliminal signals of fear
    Belinda J Liddell
    School of Psychology, University of Sydney, NSW 2006, Australia
    Neuroimage 24:235-43. 2005
    ..This network may represent an evolutionary adaptive neural 'alarm' system for rapid alerting to sources of threat, without the need for conscious appraisal...
  20. ncbi Fronto-temporal alterations within the first 200 ms during an attentional task distinguish major depression, non-clinical participants with depressed mood and healthy controls: a potential biomarker?
    Andrew H Kemp
    Brain Dynamics Centre, Westmead Millennium Institute, Westmead Hospital, Australia
    Hum Brain Mapp 30:602-14. 2009
    ..This P200 increase in depression could provide a potential mechanism for the attentional impairment frequently observed in depression and consequent alterations in the P300 may differentiate clinically significant depression...
  21. ncbi A genotype-endophenotype-phenotype path model of depressed mood: integrating cognitive and emotional markers
    Justine M Gatt
    The Brain Dynamics Center, Westmead Millennium Institute, Westmead Hospital and Western Clinical School, University of Sydney, NSW 2145, Australia
    J Integr Neurosci 6:75-104. 2007
    ..The brain-derived neurotrophic factor (BDNF) 66Met allele may contribute to both cognitive and emotional aspects of the depression phenotype...
  22. ncbi Predicting severity of non-clinical depression: preliminary findings using an integrated approach
    Andrew H Kemp
    The Brain Dynamics Center, University of Sydney and Westmead Hospital, NSW 2145, Australia
    J Integr Neurosci 5:89-110. 2006
    ..In this study, we examined the value of combining multiple domains of function in predicting depression severity...
  23. ncbi Early life stress combined with serotonin 3A receptor and brain-derived neurotrophic factor valine 66 to methionine genotypes impacts emotional brain and arousal correlates of risk for depression
    Justine M Gatt
    Brain Dynamics Center, University of Sydney Medical School and Westmead Millennium Institute, Australia
    Biol Psychiatry 68:818-24. 2010
    ..They have largely been studied in isolation...
  24. ncbi Impact of the HTR3A gene with early life trauma on emotional brain networks and depressed mood
    Justine M Gatt
    The Brain Dynamics Center, Westmead Millennium Institute and Discipline of Psychiatry, University of Sydney at Westmead Hospital, New South Wales, Australia
    Depress Anxiety 27:752-9. 2010
    ..The role of serotonin 3A receptor gene (HTR3A -42C>T polymorphism) and its interaction with early life stress (ELS) was investigated in view of the receptor's localization to brain regions central to emotion processing...
  25. ncbi Emotion brain alterations in anorexia nervosa: a candidate biological marker and implications for treatment
    Ainslie Hatch
    The Brain Dynamics Center, Westmead Millennium Institute and University of Sydney at Westmead Hospital, Australia
    J Psychiatry Neurosci 35:267-74. 2010
    ..We aimed to determine whether AN is associated with disturbances in the nonconscious neural processing of innate signals of emotion and whether these disturbances persist after weight gain...
  26. ncbi Increased absolute magnitude of gamma synchrony in first-episode psychosis
    Gary Flynn
    The Early Psychosis Intervention Program, Liverpool Hospital, and The Brain Dynamics Centre, Westmead Millennium Institute and Western Clinical School, University of Sydney, NSW, 2145, Australia
    Schizophr Res 105:262-71. 2008
    ..We hypothesized that FEP would be associated with abnormalities in absolute GPS, particularly when required to selectively attend to task-relevant stimuli...
  27. ncbi Explicit identification and implicit recognition of facial emotions: II. Core domains and relationships with general cognition
    Danielle Mathersul
    Brain Dynamics Centre, Westmead Millennium Institute and Western Clinical School, University of Sydney, Sydney, New South Wales, Australia
    J Clin Exp Neuropsychol 31:278-91. 2009
    ..These findings contribute to a normative and standardized structure for assessment of emotional and general cognition in clinical groups...
  28. ncbi Brain structure and function correlates of general and social cognition
    Donald L Rowe
    The Brain Dynamics Center, Westmead Millennium Institute, Westmead Hospital and Western Clinical School, University of Sydney, NSW 2145, Australia
    J Integr Neurosci 6:35-74. 2007
    ..To examine how general (e.g., memory, attention) and social (emotional and interpersonal processes) cognition relate to measures of brain function and structure...
  29. ncbi Volumetric white matter abnormalities in first-episode schizophrenia: a longitudinal, tensor-based morphometry study
    Thomas J Whitford
    Brain Dynamics Centre, Acacia House, Westmead Hospital, Westmead, NSW, 2145, Australia
    Am J Psychiatry 164:1082-9. 2007
    ....
  30. ncbi The dynamics of cortico-amygdala and autonomic activity over the experimental time course of fear perception
    Leanne M Williams
    The Brain Dynamics Centre, Westmead Hospital, NSW, 2145, Australia
    Brain Res Cogn Brain Res 21:114-23. 2004
    ..These findings suggest that sustained cortico-amygdala and autonomic responses may serve to prime the emotional content of fear signals, and differentiate them from initial stimulus novelty...
  31. ncbi Distinct amygdala-autonomic arousal profiles in response to fear signals in healthy males and females
    Leanne M Williams
    The Brain Dynamics Centre, Westmead Millenium Institute, Acacia House, Westmead Hospital, Westmead, NSW 2145, Australia
    Neuroimage 28:618-26. 2005
    ..We suggest that distinct evolutionary pressures might contribute to a lower threshold for vigilance to signals of danger in females, reflected in a profile of sustained amygdala-arousal interaction...
  32. ncbi Emotion perception in schizophrenia: an eye movement study comparing the effectiveness of risperidone vs. haloperidol
    Leanne M Williams
    School of Psychology, University of Sydney, Sydney, NSW 2006, Australia
    Psychiatry Res 120:13-27. 2003
    ....
  33. ncbi The integrate model of emotion, thinking and self regulation: an application to the "paradox of aging"
    Leanne M Williams
    Brain Dynamics Centre, Westmead Millennium Institute, Westmead Hospital and University of Sydney, Australia
    J Integr Neurosci 7:367-404. 2008
    ....
  34. ncbi An integrative approach to determine the best behavioral and biological markers of methylphenidate
    Daniel F Hermens
    The Brain Dynamics Center, University of Sydney and Westmead Hospital, Westmead, NSW 2145, Australia
    J Integr Neurosci 6:105-40. 2007
    ..To distinguish the most sensitive markers of methylphenidate (MPH) effects on behavior and underlying biology using an integrated cognitive and brain function test battery...
  35. ncbi Anterior cingulate activity to salient stimuli is modulated by autonomic arousal in posttraumatic stress disorder
    Kim L Felmingham
    The Brain Dynamics Centre, Westmead Millenium Institute and Western Clinical School, University of Sydney, Westmead Hospital, NSW 2145, Australia
    Psychiatry Res 173:59-62. 2009
    ..This reduction in vACC in PTSD relative to controls was not apparent in without-SCR responses. These findings suggest that a reduction in vACC in PTSD occurs specifically when arousal networks are engaged...
  36. ncbi Pathways for fear perception: modulation of amygdala activity by thalamo-cortical systems
    Pritha Das
    Neuroscience Institute of Schizophrenia and Allied Disorders NISAD, Darlinghurst, NSW, Australia
    Neuroimage 26:141-8. 2005
    ..Breakdowns in these interactions may give rise to affect-related symptoms seen in a range of neuropsychiatric disorders...
  37. ncbi Investigating the neuropsychological and neuroanatomical changes that occur over the first 2-3 years of illness in patients with first-episode schizophrenia
    Lisa Zipparo
    Department of Psychology, Macquarie University, North Ryde, NSW, Australia
    Prog Neuropsychopharmacol Biol Psychiatry 32:531-8. 2008
    ..This study explored the concurrent courses of the neuroanatomical and neuropsychological changes that occurred over the first 2-3 years of illness in patients with first-episode schizophrenia (FES)...
  38. ncbi Sex differences in functional connectivity in first-episode and chronic schizophrenia patients
    Shameran Slewa-Younan
    The Brain Dynamics Centre, Acacia House, Westmead Hospital, University of Sydney, Westmead NSW, 2145, Australia
    Am J Psychiatry 161:1595-602. 2004
    ....
  39. ncbi Distinguishing symptom profiles in adolescent ADHD using an objective cognitive test battery
    Simon D Clarke
    Brain Dynamics Centre, Westmead Millennium Institute, Westmead Hospital and Western Clinical School, University of Sydney, Westmead, NSW, 2145, Australia
    Int J Adolesc Med Health 19:355-67. 2007
    ..Currently diagnosis and assessment of ADHD relies on clinical interview and subjective ratings. Standardized objective cognitive tests can provide additional information about ADHD and help distinguish symptom profiles...
  40. ncbi Delusions and dorso-medial frontal cortex volume in first-episode schizophrenia: a voxel-based morphometry study
    Thomas J Whitford
    The Brain Dynamics Centre, Westmead Millennium Institute and University of Sydney, Westmead, NSW, 2145, Australia
    Psychiatry Res 172:175-9. 2009
    ....
  41. ncbi Influence of comorbid depression on fear in posttraumatic stress disorder: an fMRI study
    Andrew H Kemp
    Brain Dynamics Centre, Westmead Hospital and Western Clinical, School University of Sydney, Sydney, NSW, Australia
    Psychiatry Res 155:265-9. 2007
    ..Amygdala and medial prefrontal activity was reduced in PTSD-depression compared to PTSD-alone samples, highlighting the need to account for comorbidity...
  42. ncbi Longitudinal changes in neuroanatomy and neural activity in early schizophrenia
    Thomas J Whitford
    The Brain Dynamics Centre, Westmead Millennium Institute and University of Sydney, and Acacia House, Westmead Hospital, New South Wales, Australia
    Neuroreport 18:435-9. 2007
    ..These results suggest that first-episode schizophrenia may be associated with abnormally elevated levels of neural synchrony...
  43. ncbi Toward an integrated profile of depression: evidence from the brain resource international database
    Andrew H Kemp
    The Brain Dynamics Center, University of Sydney and Westmead Hospital, NSW 2145, Australia
    J Integr Neurosci 4:95-106. 2005
    ..Longitudinal studies are needed to determine the extent to which of these findings will have utility for the prediction of depression onset and treatment response/non-response...
  44. ncbi In first presentation adolescent anorexia nervosa, do cognitive markers of underweight status change with weight gain following a refeeding intervention?
    Ainslie Hatch
    The Brain Dynamics Centre, Westmead Millennium Institute and University of Sydney, Westmead Hospital, Westmead, Sydney, New South Wales, Australia
    Int J Eat Disord 43:295-306. 2010
    ..To determine the nature and severity of cognitive functioning impairment in adolescent anorexia nervosa (AN) when underweight and following weight gain...
  45. ncbi Neurophysiological markers of contextual processing: the relationship between P3b and Gamma synchrony and their modulation by arousal, performance and individual differences
    Kristan Kang
    The Brain Dynamics Centre, Westmead Hospital, NSW, Australia
    Brain Res Cogn Brain Res 25:472-83. 2005
    ..We concluded that, in simple contextual processing, global and local elements of target stimuli are processed in parallel with little variation being shown between the sexes or resulting from increasing age...
  46. ncbi A randomized controlled trial investigation of a non-stimulant in attention deficit hyperactivity disorder (ACTION): rationale and design
    Tracey W Tsang
    Brain Dynamics Centre, Sydney Medical School and Westmead Millennium Institute, Sydney, New South Wales, Australia
    Trials 12:77. 2011
    ..This manuscript will describe the methodology and rationale for the ACTION study...
  47. ncbi Toward an integrated profile of emotional intelligence: introducing a brief measure
    Andrew H Kemp
    The Brain Dynamics Center, University of Sydney and Westmead Hospital, NSW 2145, Australia
    J Integr Neurosci 4:41-61. 2005
    ..In conclusion, examination of the way in which EI measures relate to a complementary range of psychological and biological measures may help to further elucidate this construct...
  48. ncbi BOLD, sweat and fears: fMRI and skin conductance distinguish facial fear signals
    Leanne M Williams
    Brain Dynamics Centre, University of Sydney, Westmead Hospital, NSW, 2145, Australia
    Neuroreport 16:49-52. 2005
    ..The findings suggest that fear, anger and disgust perception involves specific interactions in the neural arousal systems for emotion and motivation...
  49. ncbi Neural synchrony and gray matter variation in human males and females: integration of 40 Hz gamma synchrony and MRI measures
    Leanne M Williams
    The Brain Dynamics Center, University of Sydney and Westmead Hospital, NSW 2145, Australia
    J Integr Neurosci 4:77-93. 2005
    ..Sex differences in the profile of cortical synchronization may reflect distinct aspects of evolutionary advantage...
  50. ncbi "Gamma synchrony" in first-episode schizophrenia: a disorder of temporal connectivity?
    Matthew P Symond
    The Brain Dynamics Centre, Westmead Hospital, Westmead, N S W, 2145 Australia
    Am J Psychiatry 162:459-65. 2005
    ..To the authors' knowledge, this is the first study to investigate "gamma synchrony" in first-episode schizophrenia...
  51. ncbi Sex differences in adolescent ADHD: findings from concurrent EEG and EDA
    Daniel F Hermens
    The Brain Dynamics Centre, University of Sydney, Westmead Hospital, NSW, Australia
    Clin Neurophysiol 116:1455-63. 2005
    ..We determined whether psychophysiological differences are associated with the expression of ADHD in males and females, using simultaneously recorded electroencephalography (EEG) and electrodermal activity (EDA)...
  52. ncbi ADHD and schizophrenia phenomenology: visual scanpaths to emotional faces as a potential psychophysiological marker?
    Pamela J Marsh
    Western Clinical School, The Brain Dynamics Centre, University of Sydney, Sydney, NSW, Australia
    Neurosci Biobehav Rev 30:651-65. 2006
    ....
  53. ncbi Duration of posttraumatic stress disorder predicts hippocampal grey matter loss
    Kim Felmingham
    Brain Dynamics Centre, Westmead Millennium Institute, Westmead Hospital, Australia
    Neuroreport 20:1402-6. 2009
    ..This pattern suggests that prolonged PTSD may have cumulative adverse effects on hippocampal volume, highlighting the potential role of genetic-environmental interactions...
  54. ncbi Dysregulation of arousal and amygdala-prefrontal systems in paranoid schizophrenia
    Leanne M Williams
    The Brain Dynamics Centre, Westmead Hospital and University of Sydney, NSW, Australia
    Am J Psychiatry 161:480-9. 2004
    ..It was predicted that paranoid patients would be distinguished by a disjunction of hyperarousal but reduced amygdala and medial prefrontal activity relative to both healthy comparison subjects and patients with nonparanoid schizophrenia...
  55. ncbi Investigating models of affect: relationships among EEG alpha asymmetry, depression, and anxiety
    Danielle Mathersul
    Brain Dynamics Centre and Clinics, Westmead Millennium Institute and Western Clinical School, Westmead, Australia
    Emotion 8:560-72. 2008
    ..Findings support predictions for frontal but not posterior regions. Grouping on the basis of EEG may not be reciprocally predictive of negative mood groupings, suggesting involvement of additional factors...
  56. ncbi Neural synchrony in patients with a first episode of schizophrenia: tracking relations with grey matter and symptom profile
    Leanne M Williams
    Brain Dynamics Centre, Westmead Millennium Institute and Western Clinical School, University of Sydney, Westmead, Sydney, Australia
    J Psychiatry Neurosci 34:21-9. 2009
    ..We examined relations between 40 Hz Gamma band synchrony and grey matter in patients with schizophrenia at first episode and after 2.5 years...
  57. ncbi COMT Val(108/158)Met polymorphism effects on emotional brain function and negativity bias
    Leanne M Williams
    The Brain Dynamics Center, Sydney Medical School and Westmead Millennium Institute, Acacia House, University of Sydney at Westmead Hospital, Sydney, NSW, Westmead 2145, Australia
    Neuroimage 53:918-25. 2010
    ..The findings suggest that the COMT Met allele modulates neural substrates of negative versus positive emotion processing. This effect may contribute to negativity biases, which confer susceptibility for emotional disorders...
  58. ncbi Impact of depression heterogeneity on attention: an auditory oddball event related potential study
    Andrew H Kemp
    The School of Psychology, Brennan MacCallum, Building A18, University of Sydney, NSW 2006, Australia
    J Affect Disord 123:202-7. 2010
    ..Major depressive disorder is associated with a reduced ability to attend and concentrate, however, the extent to which attentional impairment is dependent on subtype remains to be clarified...
  59. ncbi Schizophrenia and affective disorder show different visual scanning behavior for faces: a trait versus state-based distinction?
    Carmel M Loughland
    Brain Dynamics Centre, Westmead Hospital, and Department of Psychology, University of Sydney, Australia
    Biol Psychiatry 52:338-48. 2002
    ..This study is the first to examine the specificity of these impairments to schizophrenia, by including an affective disorder psychiatric control group...
  60. ncbi Mode of functional connectivity in amygdala pathways dissociates level of awareness for signals of fear
    Leanne M Williams
    The Brain Dynamics Centre, Westmead Millenium Institute and University of Sydney, Sydney, New South Wales, 2145, Australia
    J Neurosci 26:9264-71. 2006
    ....
  61. ncbi Trauma modulates amygdala and medial prefrontal responses to consciously attended fear
    Leanne M Williams
    Brain Dynamics Centre, Westmead Hospital, Westmead, NSW 2145, Australia
    Neuroimage 29:347-57. 2006
    ..Over the time course, trauma was related to a distinct pattern of ACC and amygdala connections. The findings suggest that major life trauma may disrupt the normal pattern of medial prefrontal and amygdala regulation...
  62. ncbi Enhanced amygdala and medial prefrontal activation during nonconscious processing of fear in posttraumatic stress disorder: an fMRI study
    Richard A Bryant
    Brain Dynamics Centre, Westmead Hospital, Sydeny, New South Wales, Australia
    Hum Brain Mapp 29:517-23. 2008
    ..These data extend existing models by suggesting that the impaired MPFC activation in PTSD may be limited to conscious fear processing. Hum Brain Mapp, 2008. (c) 2007 Wiley-Liss, Inc...
  63. ncbi Grey matter deficits and symptom profile in first episode schizophrenia
    Thomas J Whitford
    The Brain Dynamics Centre, Acacia House, Westmead Hospital and Western Clinical School, University of Sydney, Westmead Hospital, Westmead, NSW 2145, Australia
    Psychiatry Res 139:229-38. 2005
    ..The results also suggest a possible structural underpinning for the abnormal brain activity typically associated with symptoms of Reality Distortion...
  64. ncbi A temporal dissociation of subliminal versus supraliminal fear perception: an event-related potential study
    Belinda J Liddell
    Westmead Hospital and University of Sydney, Westmead, Australia
    J Cogn Neurosci 16:479-86. 2004
    ....
  65. ncbi "Missing links" in borderline personality disorder: loss of neural synchrony relates to lack of emotion regulation and impulse control
    Leanne M Williams
    Brain Dynamics Centre, Westmead Hospital, Westmead, Sydney, New South Wales, Australia
    J Psychiatry Neurosci 31:181-8. 2006
    ..We used a high temporal resolution measure (40-Hz gamma phase synchrony) of brain activity to examine the connectivity of brain function in BPD...
  66. ncbi Resting EEG theta activity predicts cognitive performance in attention-deficit hyperactivity disorder
    Daniel F Hermens
    The Brain Dynamics Centre, Westmead Hospital, NSW, Australia; School of Psychology, University of Sydney, NSW, Australia
    Pediatr Neurol 32:248-56. 2005
    ..This observation has important implications for the role of trait-like biologic deficits in attention-deficit hyperactivity disorder predicting performance in information processing...
  67. ncbi Visual scanpaths to threat-related faces in deluded schizophrenia
    Melissa J Green
    Cognitive Neuroscience Unit, School of Psychology, University of Sydney, Camperdown, NSW 2006, Australia
    Psychiatry Res 119:271-85. 2003
    ..This controlled bias away from negative social stimuli in deluded schizophrenia is discussed in terms of an attentional style of 'vigilance-avoidance' operating across early and late stages of information processing...
  68. ncbi Visual scanpaths to positive and negative facial emotions in an outpatient schizophrenia sample
    Carmel M Loughland
    Cognitive Neuroscience Unit, The Brain Dynamics Centre, Westmead Hospital, Westmead, NSW 2145, Australia
    Schizophr Res 55:159-70. 2002
    ....
  69. ncbi Self-protective organization in children with conversion and somatoform disorders
    Kasia Kozlowska
    Psychological Medicine, The Children s Hospital at Westmead, Westmead, NSW 2145, Australia
    J Psychosom Res 67:223-33. 2009
    ....
  70. ncbi Synchronous gamma activity: a review and contribution to an integrative neuroscience model of schizophrenia
    Kwang-Hyuk Lee
    Cognitive Neuroscience Unit, Department of Psychology, University of Sydney, and The Brain Dynamics Centre, Westmead Hospital, 2145, Sydney, NSW, Australia
    Brain Res Brain Res Rev 41:57-78. 2003
    ..It is concluded that measures of Gamma synchrony offer a valuable window into the core integrative disturbance in schizophrenia cognition...
  71. ncbi Preservation of limbic and paralimbic structures in aging
    Stuart M Grieve
    The Brain Resource International Database, The Brain Resource Company, Ultimo, New South Wales, Australia
    Hum Brain Mapp 25:391-401. 2005
    ..Moreover, the limbic findings act as a frame of reference to explore further the effects of stress and learning on these structures in an evidence-based manner across age...
  72. ncbi Diagnosis-related regional gray matter loss over two years in first episode schizophrenia and bipolar disorder
    Tom F D Farrow
    Brain Dynamics Centre, Westmead Hospital, Westmead; SCANLab, Department of Academic Clinical Psychiatry, University of Sheffield, United Kingdom
    Biol Psychiatry 58:713-23. 2005
    ....
  73. ncbi Spatiotemporal wavelet resampling for functional neuroimaging data
    Michael Breakspear
    Brain Dynamics Centre, Westmead Hospital and University of Sydney, Sydney, Australia
    Hum Brain Mapp 23:1-25. 2004
    ..The limitations and possible extensions of the proposed technique are discussed...
  74. ncbi Sex differences in adult ADHD: a double dissociation in brain activity and autonomic arousal
    Daniel F Hermens
    The Brain Dynamics Centre, Acacia House, Westmead Hospital, Hawkesbury Road, Westmead, NSW 2145, Australia
    Biol Psychol 66:221-33. 2004
    ..By contrast, adult females (but not males) with ADHD were autonomically hypo-aroused (decreased SCL). These results suggest that distinct mechanisms may underpin adult ADHD in males and females...
  75. ncbi Functional disconnections in the direct and indirect amygdala pathways for fear processing in schizophrenia
    Pritha Das
    Neuroscience Institute of Schizophrenia and Allied Disorders, Darlinghurst, NSW 2010, Australia
    Schizophr Res 90:284-94. 2007
    ..In this study we tested the hypothesis that schizophrenia is characterized by abnormal functional connectivity in the amygdala network underlying fear perception...
  76. ncbi Improving the prediction of treatment response in depression: integration of clinical, cognitive, psychophysiological, neuroimaging, and genetic measures
    Andrew H Kemp
    Brain Dynamics Centre, Discipline of Psychological Medicine, Westmead Millennium Institute, University of Sydney, Westmead Hospital, Australia
    CNS Spectr 13:1066-86; quiz 1087-8. 2008
    ..It is proposed that a focus on standardized testing methodologies across multiple testing modalities and their integration will be crucial for translation of research findings into clinical practice...
  77. ncbi A novel method for the topographic analysis of neural activity reveals formation and dissolution of 'Dynamic Cell Assemblies'
    Michael Breakspear
    Brain Dynamics Centre, Westmead Hospital, Westmead, NSW, 2145, Australia
    J Comput Neurosci 16:49-68. 2004
    ..In particular, the character of transitions between consecutive synchronous epochs may reflect important aspects of information processing and cognitive flexibility...
  78. ncbi Dynamic organization of the emotional brain: responsivity, stability, and instability
    Leanne M Williams
    Brain Dynamics Center, Acacia House, Westmead Hospital, Westmead, Sydney, NSW, 2145, Australia
    Neuroscientist 13:349-70. 2007
    ..Variations at distinct points along this continuum, with contributions from constitutional and genetic factors, may contribute to individual differences in emotional stability and instability in neuropsychiatric disorders...
  79. ncbi The five symptom dimensions and depression in schizophrenia
    Kwang-Hyuk Lee
    Cognitive Neuroscience Unit, The Brain Dynamics Centre, Westmead Hospital, Sydney, NSW, Australia
    Psychopathology 36:226-33. 2003
    ..It is suggested that depression exists as an independent domain, differentiated from negative symptoms, in the structure of schizophrenia symptomatology...
  80. ncbi Mapping the time course of nonconscious and conscious perception of fear: an integration of central and peripheral measures
    Leanne M Williams
    School of Psychology, University of Sydney, Sydney, Australia
    Hum Brain Mapp 21:64-74. 2004
    ..By contrast, the N4 may index the conscious integration of emotion stimuli in working memory, subserved by greater cortical engagement. Hum. Brain Mapping 21:64-74, 2004...
  81. ncbi Responses to methylphenidate in adolescent AD/HD: evidence from concurrently recorded autonomic (EDA) and central (EEG and ERP) measures
    Daniel F Hermens
    The Brain Dynamics Centre, University of Sydney, Westmead Hospital, Australia
    Int J Psychophysiol 58:21-33. 2005
    ..This dissociation of resting and task-related activity may prove to be useful in elucidating the effects of stimulant versus new non-stimulant medications in AD/HD...
  82. ncbi The multiscale character of evoked cortical activity
    Michael Breakspear
    The Black Dog Institute, Hospital Rd, Prince of Wales Hospital and The School of Psychiatry, University of New South Wales, Randwick, NSW 2031, Australia
    Neuroimage 30:1230-42. 2006
    ..It also affords a quantitative means of testing hierarchical and multiscale models of cortical activity...
  83. ncbi Task instructions modulate neural responses to fearful facial expressions
    Kezia Lange
    Institute of Psychiatry, London, United Kingdom
    Biol Psychiatry 53:226-32. 2003
    ..CONCLUSIONS: Neural responses to fearful facial expressions are modulated by task instructions...
  84. ncbi Face to face: visual scanpath evidence for abnormal processing of facial expressions in social phobia
    Kaye Horley
    Department of Psychology, University of Wollongong 2522, Australia
    Psychiatry Res 127:43-53. 2004
    ..These findings are consistent with theories emphasising the role of information processing biases in social phobia, and show promise in the application to treatment evaluation in this disorder...
  85. ncbi Differential neural responses to overt and covert presentations of facial expressions of fear and disgust
    Mary L Phillips
    Section of Neuroscience and Emotion, Department of Psychological Medicine, Institute of Psychiatry, KCL, London, UK
    Neuroimage 21:1484-96. 2004
    ..These results therefore suggest distinct neural correlates of conscious and unconscious emotion perception...
  86. ncbi EEG markers for cognitive decline in elderly subjects with subjective memory complaints
    David M Alexander
    The Brain Resource Company and the Brain Resource International Database, Ultimo, NSW 2007, Australia
    J Integr Neurosci 5:49-74. 2006
    ....
  87. ncbi Standardized assessment of cognitive functioning during development and aging using an automated touchscreen battery
    C Richard Clark
    School of Psychology, Flinders University, P O Box 2100, Adelaide, SA 5001, Australia
    Arch Clin Neuropsychol 21:449-67. 2006
    ..Overall, the test battery provided sensitive indicators on a range of cognitive functions suitable for the assessment of abnormal cognition, the evaluation of treatment effects and for longitudinal case management...
  88. ncbi BDNF Val66Met polymorphism is associated with body mass index in healthy adults
    John Gunstad
    Department of Psychology, Kent State University, Kent, Ohio, USA
    Neuropsychobiology 53:153-6. 2006
    ..These findings suggest a possible relationship between Val66Met polymorphism and BMI in healthy adults. Further work is needed to clarify possible mechanisms for this relationship...
  89. ncbi Cognitive status of young and older cigarette smokers: data from the international brain database
    Robert H Paul
    Centers for Behavioral and Preventive Medicine, Department of Psychiatry, Brown Medical School, Providence, RI 02903, USA
    J Clin Neurosci 13:457-65. 2006
    ..Cigarette smoking is associated with isolated and subtle cognitive difficulties among very healthy individuals...
  90. ncbi Regional white matter and neuropsychological functioning across the adult lifespan
    Adam M Brickman
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Columbia University Medical Center, New York, NY 10032, USA
    Biol Psychiatry 60:444-53. 2006
    ..The current study utilized magnetic resonance imaging (MRI) to more fully elucidate the relationship among age, regional white matter, and neuropsychological functioning...
  91. ncbi Event-related wave activity in the EEG provides new marker of ADHD
    David M Alexander
    The Brain Resource International Database, Brain Resource Company, Sydney, Australia
    Clin Neurophysiol 119:163-79. 2008
    ..This study examines the utility of new measures of event-related spatio-temporal waves in the EEG as a marker of ADHD, previously shown to be closely related to the P3 ERP in an adult sample...
  92. ncbi Early life stress and morphometry of the adult anterior cingulate cortex and caudate nuclei
    Ronald A Cohen
    Department of Psychiatry and Human Behavior, Brown University, Providence, Rhode Island, USA
    Biol Psychiatry 59:975-82. 2006
    ..We examine whether reported adverse ELS defined as stressful and/or traumatic adverse childhood events (ACEs) is associated with smaller limbic and basal ganglia volumes...
  93. ncbi Distractibility in AD/HD predominantly inattentive and combined subtypes: the P3a ERP component, heart rate and performance
    Hannah A D Keage
    Cognitive Neuroscience Laboratory, School of Psychology, Flinders University, SA 5042, Australia
    J Integr Neurosci 5:139-58. 2006
    ..AD/HD groups also displayed a number of deficits on Switching of Attention and Verbal Memory tasks, however, the pattern of abnormality mostly reflected general cognitive deficits rather than resulting from distraction...
  94. ncbi Putative biomarker of working memory systems development during childhood and adolescence
    Hannah A D Keage
    Cognitive Neuroscience Laboratory, Flinders University, Australia
    Neuroreport 19:197-201. 2008
    ..This outcome identifies a biomarker with the potential for assessing abnormalities in the rate of brain development...
  95. ncbi Resting electroencephalogram asymmetry and posttraumatic stress disorder
    Stewart A Shankman
    Department of Psychology and Psychiatry, University of Illinois at Chicago, Chicago, IL 60607, USA
    J Trauma Stress 21:190-8. 2008
    ..g., major depressive disorder, panic disorder)...
  96. ncbi Preliminary validity of "integneuro": a new computerized battery of neurocognitive tests
    Robert H Paul
    Department of Psychiatry, Centers for Behavioral and Preventive Medicine, Brown Medical School, Providence, Rhode Island 02903, USA
    Int J Neurosci 115:1549-67. 2005
    ..These results support the use of IntegNeuro as a computerized cognitive system. Additional studies are needed to examine the clinical utility of the battery...
  97. ncbi Neural networks of information processing in posttraumatic stress disorder: a functional magnetic resonance imaging study
    Richard A Bryant
    School of Psychology, University of New South Wales, Sydney, Australia
    Biol Psychiatry 58:111-8. 2005
    ..We investigated whether anterior cingulate-amygdala dysregulation in PTSD would generalize to salient, but nonthreat related signals...
  98. ncbi The dose-dependent effect of methylphenidate on performance, cognition and psychophysiology
    Nicholas J Cooper
    The Brain Resource Company and the Brain Resource International Database, Ultimo, NSW 2007, Australia
    J Integr Neurosci 4:123-44. 2005
    ..To our knowledge, this is the first paper to use behavioral, arousal and electrophysiological measures in an integrative approach to study the effects of MPH on healthy adults...
  99. ncbi Age-dependent change in executive function and gamma 40 Hz phase synchrony
    Robert H Paul
    Centers for Behavioral and Preventive Medicine, Department of Psychiatry and Human Behavior, Brown Medical School, Providence, RI 02903, USA
    J Integr Neurosci 4:63-76. 2005
    ....
  100. ncbi The relationship between frontal gray matter volume and cognition varies across the healthy adult lifespan
    Molly E Zimmerman
    Department of Psychiatry and Human Behavior, Brown Medical School, Providence, Rhode Island, USA
    Am J Geriatr Psychiatry 14:823-33. 2006
    ..The goal of the current study is to examine the relationship between age-related changes in regional gray matter volumes and cognitive function in a large, cross-sectional sample of healthy adults across the lifespan...