Mark D P Willcox

Summary

Affiliation: University of New South Wales
Country: Australia

Publications

  1. doi Contact lens case contamination during daily wear of silicone hydrogels
    Mark D P Willcox
    Institute for Eye Research, University of New South Wales, Sydney, New South Wales, Australia
    Optom Vis Sci 87:456-64. 2010
  2. pmc Role of carnitine in disease
    Judith L Flanagan
    Institute for Eye Research, Sydney, New South Wales, Australia
    Nutr Metab (Lond) 7:30. 2010
  3. doi A novel cationic-peptide coating for the prevention of microbial colonization on contact lenses
    M D P Willcox
    Institute for Eye Research, The University of New South Wales UNSW, Sydney, NSW, Australia
    J Appl Microbiol 105:1817-25. 2008
  4. ncbi Pseudomonas aeruginosa infection and inflammation during contact lens wear: a review
    Mark D P Willcox
    Institute for Eye Research, Vision CRC and School of Optometry and Vision Science, University of New South Wales, Australia
    Optom Vis Sci 84:273-8. 2007
  5. ncbi New strategies to prevent Pseudomonas keratitis
    Mark D P Willcox
    Institute for Eye Research, University of New South Wales, Sydney, New South Wales, Australia
    Eye Contact Lens 33:401-3; discussion 410-1. 2007
  6. doi Interactions of lens care with silicone hydrogel lenses and effect on comfort
    Mark D P Willcox
    Brien Holden Vision Institute, The University of New South Wales, Sydney, New South Wales, Australia
    Optom Vis Sci 87:839-46. 2010
  7. ncbi The corneal response to infection with Staphylococcus aureus in the absence of interleukin-4
    Nerida Cole
    Institute for Eye Research, University of New South Wales, Sydney, NSW 2052, Australia
    Immunol Cell Biol 85:333-7. 2007
  8. ncbi A protective role for IL-6 in staphylococcal microbial keratitis
    Emma B H Hume
    The School of Optometry and Vision Science, The University of New South Wales, Kensington, NSW 2052, Australia
    Invest Ophthalmol Vis Sci 47:4926-30. 2006
  9. ncbi Interleukin-4 is not critical to pathogenesis in a mouse model of Pseudomonas aeruginosa corneal infection
    Nerida Cole
    Institute for Eye Research, Kensington, NSW, Australia
    Curr Eye Res 30:535-42. 2005
  10. doi Comparison of virulence factors in Pseudomonas aeruginosa strains isolated from contact lens- and non-contact lens-related keratitis
    Man H Choy
    School of Optometry and Vision Science, University of New South Wales, Sydney, Australia
    J Med Microbiol 57:1539-46. 2008

Collaborators

Detail Information

Publications92

  1. doi Contact lens case contamination during daily wear of silicone hydrogels
    Mark D P Willcox
    Institute for Eye Research, University of New South Wales, Sydney, New South Wales, Australia
    Optom Vis Sci 87:456-64. 2010
    ..This study aimed to evaluate the contamination rate and types of microbes contaminating cases during use of contact lens disinfecting solutions and silicone hydrogel lenses...
  2. pmc Role of carnitine in disease
    Judith L Flanagan
    Institute for Eye Research, Sydney, New South Wales, Australia
    Nutr Metab (Lond) 7:30. 2010
    ....
  3. doi A novel cationic-peptide coating for the prevention of microbial colonization on contact lenses
    M D P Willcox
    Institute for Eye Research, The University of New South Wales UNSW, Sydney, NSW, Australia
    J Appl Microbiol 105:1817-25. 2008
    ....
  4. ncbi Pseudomonas aeruginosa infection and inflammation during contact lens wear: a review
    Mark D P Willcox
    Institute for Eye Research, Vision CRC and School of Optometry and Vision Science, University of New South Wales, Australia
    Optom Vis Sci 84:273-8. 2007
    ..This can ultimately lead to scarring and vision loss...
  5. ncbi New strategies to prevent Pseudomonas keratitis
    Mark D P Willcox
    Institute for Eye Research, University of New South Wales, Sydney, New South Wales, Australia
    Eye Contact Lens 33:401-3; discussion 410-1. 2007
    ..To review the options for preventing the development of microbial keratitis during contact lens wear...
  6. doi Interactions of lens care with silicone hydrogel lenses and effect on comfort
    Mark D P Willcox
    Brien Holden Vision Institute, The University of New South Wales, Sydney, New South Wales, Australia
    Optom Vis Sci 87:839-46. 2010
    ..The purpose of this study was to investigate the effect of lens care products on short-term subjective and physiological performance silicone hydrogel lenses...
  7. ncbi The corneal response to infection with Staphylococcus aureus in the absence of interleukin-4
    Nerida Cole
    Institute for Eye Research, University of New South Wales, Sydney, NSW 2052, Australia
    Immunol Cell Biol 85:333-7. 2007
    ..This information may lead to the development of novel therapeutic strategies potentially improving the prognosis for infection of this unique avascular site...
  8. ncbi A protective role for IL-6 in staphylococcal microbial keratitis
    Emma B H Hume
    The School of Optometry and Vision Science, The University of New South Wales, Kensington, NSW 2052, Australia
    Invest Ophthalmol Vis Sci 47:4926-30. 2006
    ....
  9. ncbi Interleukin-4 is not critical to pathogenesis in a mouse model of Pseudomonas aeruginosa corneal infection
    Nerida Cole
    Institute for Eye Research, Kensington, NSW, Australia
    Curr Eye Res 30:535-42. 2005
    ..To determine the contribution of interleukin-4 (IL-4) to the initial host response during corneal infection with Pseudomonas aeruginosa in a mouse model...
  10. doi Comparison of virulence factors in Pseudomonas aeruginosa strains isolated from contact lens- and non-contact lens-related keratitis
    Man H Choy
    School of Optometry and Vision Science, University of New South Wales, Sydney, Australia
    J Med Microbiol 57:1539-46. 2008
    ..aeruginosa isolates from different infection origins may have different characteristics. A better understanding of these differences may lead to further development of evidence-based clinical guidelines for the management of keratitis...
  11. doi Contact lens deposits, adverse responses, and clinical ocular surface parameters
    Zhenjun Zhao
    Institute for Eye Research, Sydney, New South Wales, Australia
    Optom Vis Sci 87:669-74. 2010
    ..To correlate clinical responses during contact lens wear with the amount of protein or cholesterol extracted from lenses after wear...
  12. doi In vivo performance of melimine as an antimicrobial coating for contact lenses in models of CLARE and CLPU
    Nerida Cole
    Institute for Eye Research, The University of New South Wales, Sydney, NSW, Australia
    Invest Ophthalmol Vis Sci 51:390-5. 2010
    ..Cationic peptides represent a novel approach for the development of antimicrobial lenses...
  13. doi Evaluation of synergistic activity of bovine lactoferricin with antibiotics in corneal infection
    Thein Zaw Oo
    Brien Holden Vision Institute, Sydney, New South Wales, Australia
    J Antimicrob Chemother 65:1243-51. 2010
    ....
  14. ncbi A Staphylococcus aureus mouse keratitis topical infection model: cytokine balance in different strains of mice
    Emma B H Hume
    The School of Optometry and Vision Science, The University of New South Wales, Australia
    Immunol Cell Biol 83:294-300. 2005
    ..IL-4, IL-10 and IL-6 cytokines may be protective during Gram-positive corneal infection and therefore may be useful for adjunct therapies in the treatment of this disease...
  15. ncbi Type III secretion system-associated toxins, proteases, serotypes, and antibiotic resistance of Pseudomonas aeruginosa isolates associated with keratitis
    Hua Zhu
    Institute for Eye Research, School of Optometry and Vision Science, The University of New South Wales, Sydney, Australia
    Curr Eye Res 31:297-306. 2006
    ..01). The results suggest that multidrug resistance may be more commonly associated with the corneal isolates of P. aeruginosa having type III secretion system-associated cytotoxin gene exoU and belonging to serotype E (O:11) group...
  16. ncbi Effects of alpha-toxin-deficient Staphylococcus aureus on the production of peripheral corneal ulceration in an animal model
    Peter Z J Wu
    Vision Cooperative Research Centre and Cornea and Contact Lens Research Unit, School of Optometry and Vision Science, University of New South Wales, Sydney, NSW, Australia
    Curr Eye Res 30:63-70. 2005
    ..To examine the role of Staphylococcus aureus alpha-toxin in contact lens-induced peripheral ulceration (CLPU)...
  17. doi Protein deposition and its effect on bacterial adhesion to contact lenses
    Negar Babaei Omali
    Brien Holden Vision Institute, School of Optometry and Vision Science, University of New South Wales, Sydney, New South Wales, Australia
    Optom Vis Sci 90:557-64. 2013
    ..This study examined the effect of combinations of proteins on the adhesion of bacteria to contact lenses...
  18. doi Effect of antibiotic drops on adverse events during extended lens wear
    Jerome Ozkan
    BOptom PhD, FBCLA, FAAO, MASM MBBS, DO BSc Optom PhD PhD, DSC, FAAO Brien Holden Vision Institute JO, hz, PLdlJ, TN, BAH and School of Optometry and Vision Science, University of New South Wales JO, MDPW, hz, PLdlJ, BAH, Sydney, New South Wales, Australia and LV Prasad Eye Institute VR, DS, Hyderabad, India
    Optom Vis Sci 91:13-23. 2014
    ....
  19. doi Effect of phospholipid deposits on adhesion of bacteria to contact lenses
    Negar Babaei Omali
    Brien Holden Vision Institute, Sydney, New South Wales, Australia
    Optom Vis Sci 89:52-61. 2012
    ..Protein and lipid deposits on contact lenses may contribute to clinical complications. This study examined the effect of phospholipids on the adhesion of bacteria to contact lenses...
  20. pmc Proteomic analysis of protein deposits on worn daily wear silicone hydrogel contact lenses
    Zhenjun Zhao
    Institute for Eye Research, Sydney, NSW, Australia
    Mol Vis 14:2016-24. 2008
    ..In this study, we used proteomic techniques to analyze the protein deposits extracted from worn daily wear silicone hydrogel contact lenses in combination with different lens care solutions...
  21. ncbi A critical role for CCL2 and CCL3 chemokines in the regulation of polymorphonuclear neutrophils recruitment during corneal infection in mice
    Mei Lang Xue
    Vision Cooperative Research Centre, Sydney, NSW, Australia
    Immunol Cell Biol 85:525-31. 2007
    ..Our findings provide strong evidence that CCL2 and CCL3 are critical regulators of PMN recruitment, and may lead to therapeutic strategies via targeting of the CC chemokines, CCL2 and CCL3, in the management of P. aeruginosa keratitis...
  22. doi Immune defense single nucleotide polymorphisms and recruitment strategies associated with contact lens keratitis
    Nicole A Carnt
    Brien Holden Vision Institute, Sydney, Australia
    Ophthalmology 119:1997-2002. 2012
    ..To determine the association of single nucleotide polymorphisms (SNPs) of defensin 1B and toll-like receptor 4 with contact lens keratitis susceptibility and severity, and to understand the factors that influence study participation...
  23. pmc Quorum-sensing regulation of adhesion in Serratia marcescens MG1 is surface dependent
    Maurizio Labbate
    School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW, Australia
    J Bacteriol 189:2702-11. 2007
    ..marcescens MG1 utilizes different regulatory systems and adhesins in attachment to biotic and abiotic surfaces and that QS is a main regulatory pathway in adhesion to an abiotic surface but not in adhesion to a biotic surface...
  24. ncbi Salicylic acid reduces the production of several potential virulence factors of Pseudomonas aeruginosa associated with microbial keratitis
    Mahesh B K Bandara
    Vision Cooperative Research Centre, Sydney, Australia
    Invest Ophthalmol Vis Sci 47:4453-60. 2006
    ..The purpose of this study was to test the effect of salicylic acid on the production of potential virulence factors during the growth of P. aeruginosa...
  25. doi Fimbrolide-coated antimicrobial lenses: their in vitro and in vivo effects
    Hua Zhu
    Institute for Eye Research, University of New South Wales, Sydney, New South Wales, Australia
    Optom Vis Sci 85:292-300. 2008
    ..To examine the ability of contact lenses coated with fimbrolides, inhibitors of bacterial quorum sensing, to prevent microbial adhesion and their safety during short-term clinical assessment...
  26. ncbi Pseudomonas aeruginosa with lasI quorum-sensing deficiency during corneal infection
    Hua Zhu
    Cooperative Research Centre for Eye Research and Technology, University of New South Wales, Sydney, Australia
    Invest Ophthalmol Vis Sci 45:1897-903. 2004
    ....
  27. pmc Decrease in hyperosmotic stress-induced corneal epithelial cell apoptosis by L-carnitine
    Neeta Khandekar
    Brien Holden Vision Institute, Sydney, Australia
    Mol Vis 19:1945-56. 2013
    ..To characterize the osmoprotective properties of L-carnitine on human corneal epithelial cell volume and apoptosis during hyperosmotic stress...
  28. ncbi Biocompatibility of antimicrobial melimine lenses: rabbit and human studies
    Debarun Dutta
    BOptom PhD, FAAO School of Optometry and Vision Science, The University of New South Wales, Sydney, New South Wales, Australia DD, JO, MDPW and Brien Holden Vision Institute, Sydney, New South Wales, Australia DD, JO
    Optom Vis Sci 91:570-81. 2014
    ..The purpose of this study was to investigate the performance of melimine-coated contact lenses in an animal model and human clinical trial...
  29. doi Effect of a warming device on contact lens case contamination
    Mark D P Willcox
    Brien Holden Vision Institute, University of New South Wales, Sydney, Australia
    Eye Contact Lens 38:394-9. 2012
    ..To examine the effectiveness of heating contact lens cases after disinfection on reducing microbial contamination...
  30. doi Bacterial adhesion to unworn and worn silicone hydrogel lenses
    Ajay Kumar Vijay
    Brien Holden Vision Institute, University of New South Wales, Sydney, New South Wales, Australia
    Optom Vis Sci 89:1095-106. 2012
    ..The objective of this study was to determine the bacterial adhesion to various silicone hydrogel lens materials and to determine whether lens wear modulated adhesion...
  31. ncbi Secretory phospholipase A2 deposition on contact lenses and its effect on bacterial adhesion
    Emma B H Hume
    Vision Cooperative Research Centre, The University of New South Wales, Sydney, New South Wales, Australia
    Invest Ophthalmol Vis Sci 45:3161-4. 2004
    ..The purpose was to determine whether sPLA2 deposition is associated with contact lens (CL) type, if sPLA2 remains active on CLs, and if this has an effect on bacterial adhesion...
  32. ncbi Adhesion of Pseudomonas aeruginosa to orthokeratology and alignment lenses
    Jennifer D Choo
    Institute for Eye Research, Sydney, New South Wales, Australia
    Optom Vis Sci 86:93-7. 2009
    ..To determine whether contact lenses designed for orthokeratology (OK) are colonized by greater numbers of bacteria compared with standard (alignment fitted) design rigid gas permeable lenses before and after lens wear...
  33. ncbi Care regimen and lens material influence on silicone hydrogel contact lens deposition
    Zhenjun Zhao
    Institute for Eye Research, Sydney, Australia
    Optom Vis Sci 86:251-9. 2009
    ..To quantitatively detect proteins and cholesterol extracted from worn silicone hydrogel contact lenses and determine the effect of various lens care solutions on deposit accumulation...
  34. doi Characterisation and in vitro activities of surface attached dihydropyrrol-2-ones against Gram-negative and Gram-positive bacteria
    Kitty K K Ho
    School of Chemistry, University of New South Wales, Sydney, NSW, Australia
    Biofouling 26:913-21. 2010
    ....
  35. doi Corneal erosions, bacterial contamination of contact lenses, and microbial keratitis
    Mark D P Willcox
    Brien Holden Vision Institute University of New South Wales, Sydney, Australia
    Eye Contact Lens 36:340-5. 2010
    ..To estimate the rate of corneal erosion coupled with gram-negative bacterial contamination of contact lenses and compare this with the rate of microbial keratitis (MK) with contact lenses...
  36. doi Risk factors for corneal inflammatory and mechanical events with extended wear silicone hydrogel contact lenses
    Jerome Ozkan
    Brien Holden Vision Institute, New South Wales, Queensland, Australia
    Optom Vis Sci 87:847-53. 2010
    ..To identify risk factors for contact lens-related corneal inflammatory events and mechanical events in wearers of silicone hydrogel lenses on a 30-night extended wear (EW) schedule in India...
  37. doi Guinea pig models of acute keratitis responses
    Ajay Kumar Vijay
    Vision CRC, University of New South Wales, Sydney, Australia
    Cornea 28:1153-9. 2009
    ..Development of animal models to study these conditions is of importance in confirming risk factors and developing preventative strategies...
  38. ncbi Efficacy of contact lens multipurpose solutions against serratia marcescens
    Emma B H Hume
    Institute for Eye Research, Sydney, New South Wales, Australia
    Optom Vis Sci 84:316-20. 2007
    ..To compare the susceptibilities of clinical isolates of Serratia marcescens and the standard ISO ATCC 13880 strain to five contact lens multipurpose disinfection solutions (MPDSs)...
  39. doi Rapid quantification of free cholesterol in tears using direct insertion/electron ionization-mass spectrometry
    Xiaojia Eric Wei
    School of Optometry and Vision Science, University of New South Wales, Sydney, Australia
    Invest Ophthalmol Vis Sci 54:8027-35. 2013
    ..To establish a simple and rapid analytical method, based on direct insertion/electron ionization-mass spectrometry (DI/EI-MS), for measuring free cholesterol in tears from humans and rabbits...
  40. doi Effect of lens care systems on the clinical performance of a contact lens
    Percy Lazon de la Jara
    The Brien Holden Vision Institute, Sydney, New South Wales, Australia
    Optom Vis Sci 90:344-50. 2013
    ..To evaluate subjective responses, rates of solution-induced corneal staining (SICS), and corneal infiltrative events (CIEs) associated with a silicone hydrogel when worn under a daily disposable (DD) or daily wear (DW) modality...
  41. pmc Quantification of individual proteins in silicone hydrogel contact lens deposits
    Negar Babaei Omali
    Brien Holden Vision Institute, University of New South Wales, Sydney, Australia
    Mol Vis 19:390-9. 2013
    ....
  42. doi Characterization of chemoselective surface attachment of the cationic peptide melimine and its effects on antimicrobial activity
    Renxun Chen
    School of Chemistry, University of New South Wales, Sydney, NSW 2052, Australia
    Acta Biomater 8:4371-9. 2012
    ....
  43. doi Broad spectrum antimicrobial activity of melimine covalently bound to contact lenses
    Debarun Dutta
    Brien Holden Vision Institute, Sydney NSW, Australia
    Invest Ophthalmol Vis Sci 54:175-82. 2013
    ....
  44. doi In vitro adsorption of tear proteins to hydroxyethyl methacrylate-based contact lens materials
    Fiona P Carney
    Vision Cooperative Research Centre, Sydney, New South Wales, Australia
    Eye Contact Lens 35:320-8. 2009
    ..Quantity and tenacity of binding of significant tear components to groups I and IV contact lenses was assessed. Competitive binding by these components was also examined...
  45. ncbi Isolation of conjunctival mucin and differential interaction with Pseudomonas aeruginosa strains of varied pathogenic potential
    Lina Panayiota Aristoteli
    Cooperative Research Centre for Eye Research and Technology, University of New South Wales, Sydney, NSW 2052, Australia
    Exp Eye Res 77:699-710. 2003
    ..It is proposed that more avid mucin-adhering strains are given the opportunity to adhere and subsequently penetrate the mucous layer of the tear film to initiate pathogenesis...
  46. ncbi Lid and conjunctival micro biota during contact lens wear in children
    Padmaja R Sankaridurg
    Institute for Eye Research, Level 4, Rupert Myers Building, Gate 14, Barker Street Kensington, NSW 2033, Australia
    Optom Vis Sci 86:312-7. 2009
    ..To determine the types of microorganisms and their frequency of isolation on the external ocular surface in children wearing soft contact lenses on a daily wear schedule...
  47. doi Contact lens-related adverse events and the silicone hydrogel lenses and daily wear care system used
    Nicole A Carnt
    BOptom, Institute for Eye Research, Level 3, Rupert Myers Building, University of New South Wales, Sydney, NSW 2052, Australia
    Arch Ophthalmol 127:1616-23. 2009
    ..To investigate the incidence of adverse events related to the use of varying silicone hydrogel contact lens and lens solution combinations...
  48. ncbi Effects of topical administration of 12-methyl tetradecanoic acid (12-MTA) on the development of corneal angiogenesis
    Nerida Cole
    Institute for Eye Research, Level 4, Rupert Myers Building, Gate 14, Barker Street, Kensington, Sydney, NSW 2052, Australia
    Angiogenesis 10:47-54. 2007
    ..Our studies indicate that 12-MTA may provide clinically significant advantages over conventional steroids for the treatment of vessel growth in the cornea...
  49. doi Effect of cholesterol deposition on bacterial adhesion to contact lenses
    Negar Babaei Omali
    Brien Holden Vision Institute, Level 5, North Wing, RMB, Gate 14, Barker Street, University of New South Wales, Sydney 2052, NSW Australia
    Optom Vis Sci 88:950-8. 2011
    ..To examine the effect of cholesterol on the adhesion of bacteria to silicone hydrogel contact lenses...
  50. doi Importance of rub and rinse in use of multipurpose contact lens solution
    Hua Zhu
    Brien Holden Vision Institute, Level 5, North Wing, Rupert Myers Building, University of New South Wales, Sydney, NSW 2052, Australia
    Optom Vis Sci 88:967-72. 2011
    ..The aim of the study was to evaluate the effect of various regimen steps on the efficacy of MPDS when used with silicone hydrogel and conventional lenses...
  51. doi Pseudomonas aeruginosa quorum-sensing signal molecules induce IL-8 production by human corneal epithelial cells
    Hua Zhu
    Institute for Eye Research, Vision CRC and School of Optometry and Vision Science, The University of New South Wales, Sydney, NSW 2052, Australia
    Eye Contact Lens 34:179-81. 2008
    ..The aim of the present study was to evaluate whether the quorum-sensing molecules of Pseudomonas aeruginosa could induce the production of interleukin-8 (IL-8) in human corneal epithelial (HCE) cells in vitro...
  52. ncbi The role of CXC chemokine receptor 2 in Pseudomonas aeruginosa corneal infection
    Shamila Khan
    Intitute for Eye Research, and School of Optometry, University of New South Wales, Sydney, NSW 2052, Australia
    J Leukoc Biol 81:315-8. 2007
    ..These results imply that CXCR2 is critical to the extravasation of neutrophils into the avascular cornea...
  53. ncbi Complications associated with care product use during silicone daily wear of hydrogel contact lens
    Eric B Papas
    The Institute for Eye Research, The University of New South Wales, Sydney, NSW, Australia
    Eye Contact Lens 33:392-3; discussion 399-400. 2007
    ..Options for achieving this include use of low impact lens/MPS combinations, daily disposable lenses or hydrogen peroxide based disinfection systems...
  54. ncbi Broad spectrum of antibacterial activity of a new multipurpose disinfecting solution
    Hua Zhu
    Institute for Eye Research, School of Optometry and Vision Science, University of New South Wales, Sydney, Australia
    Eye Contact Lens 33:278-83. 2007
    ..001% polyquaternium-1 and 0.0005% myristamidopropyl dimethylamine, against a range of bacteria and fungi...
  55. doi Synthesis, characterization and in vitro activity of a surface-attached antimicrobial cationic peptide
    Renxun Chen
    University of New South Wales, Sydney, Australia
    Biofouling 25:517-24. 2009
    ..Further, it was observed that the efficacy of antimicrobial activity is related to the method of attachment...
  56. doi Soft contact lens disinfection solution efficacy: clinical Fusarium isolates vs. ATCC 36031
    Emma B H Hume
    Institute for Eye Research, The School of Optometry and Vision Science, The University of New South Wales, Kensington, New South Wales, Australia
    Optom Vis Sci 86:415-9. 2009
    ..To compare the disinfecting efficacy of five soft contact lens multipurpose disinfection solutions (MPDS) against Fusarium solani clinical isolates and the ISO standard ATCC 36031 strain...
  57. doi Association of single nucleotide polymorphisms of interleukins-1β, -6, and -12B with contact lens keratitis susceptibility and severity
    Nicole A Carnt
    Brien Holden Vision Institute, Australia
    Ophthalmology 119:1320-7. 2012
    ..To investigate whether single nucleotide polymorphisms (SNPs) in interleukin (IL)-1β, IL-6, and IL-12β are associated with the susceptibility and severity of contact lens-related keratitis...
  58. doi Pilot study of contact lens practitioner risk-taking propensity
    Nicole Carnt
    Brien Holden Vision Institute, Sydney, New South Wales, Australia
    Optom Vis Sci 88:E981-7. 2011
    ..Other factors associated with high practitioner risk taking and larger volume contact lens practices were also investigated...
  59. doi Effect of prophylactic antibiotic drops on ocular microbiota and physiology during silicone hydrogel lens wear
    Jerome Ozkan
    Brien Holden Vision Institute, Sydney, New South Wales, Australia
    Optom Vis Sci 89:326-35. 2012
    ..The aim of this study was to investigate the effect of prophylactic topical antibiotic instillation during continuous wear of silicone hydrogel lenses on the normal ocular microbiota, the throat microbiota, and the ocular physiology...
  60. doi Characterization of protease IV expression in Pseudomonas aeruginosa clinical isolates
    Tim C R Conibear
    School of Optometry and Vision Science, University of New South Wales, Sydney, Australia
    J Med Microbiol 61:180-90. 2012
    ..Observed variations within the gene sequence appear to correlate with presence of specific TTSS genes. Protease IV expression was shown to be regulated by the Las quorum-sensing system...
  61. doi Impact of lens case hygiene guidelines on contact lens case contamination
    Yvonne T Wu
    School of Optometry and Vision Science, University of New South Wales, Sydney, New South Wales, Australia
    Optom Vis Sci 88:E1180-7. 2011
    ..The effectiveness of manufacturers' lens case cleaning guidelines in limiting microbial contamination has not been evaluated in vivo. This study compared the effectiveness of manufacturers' guidelines and an alternative cleaning regimen...
  62. doi Detection and quantification of tear phospholipids and cholesterol in contact lens deposits: the effect of contact lens material and lens care solution
    Jennifer T Saville
    School of Chemistry, University of Wollongong, Wollongong, New South Wales, Australia
    Invest Ophthalmol Vis Sci 51:2843-51. 2010
    ..To examine the deposition of tear phospholipids and cholesterol onto worn contact lenses and the effect of lens material and lens care solution...
  63. doi Staphylococcus aureus ocular isolates from symptomatic adverse events: antibiotic resistance and similarity of bacteria causing adverse events
    Tracey L Schubert
    The School of Optometry and Vision Science, University of New South Wales, NSW, Australia
    Clin Exp Optom 91:148-55. 2008
    ..aureus isolates and also determine whether isolates from different adverse events or those with similar antimicrobial susceptibilities are related...
  64. ncbi The adhesion of Pseudomonas aeruginosa to high molecular weight human tear film species corresponds to glycoproteins reactive with Sambucus nigra lectin
    Lina Panayiota Aristoteli
    Cooperative Research Centre for Eye Research and Technology, The University of New South Wales, Sydney NSW 2052, Australia
    Exp Eye Res 83:1146-53. 2006
    ..aeruginosa ocular strains, and S. nigra lectin seemed to enhance the interaction. The study provides a basis for direct investigation of bacterial adhesion to glycoproteins with an apparent migration >200 kDa in tear fluid...
  65. ncbi Regulation of MMPs and TIMPs by IL-1beta during corneal ulceration and infection
    Mei Lang Xue
    Cooperative Research Centre for Eye Research and Technology and Cornea and Contact Lens Research Unit, School of Optometry and Vision Science, The University of New South Wales, Sydney, New South Wales, Australia
    Invest Ophthalmol Vis Sci 44:2020-5. 2003
    ..This study was conducted to investigate the role of IL-1beta in the regulation of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) in a mouse model of experimental keratitis and corneal injury...
  66. ncbi The induction and suppression of the apoptotic response of HSV-1 in human corneal epithelial cells
    David H Miles
    Vision Cooperative Research Centre, Sydney, Australia
    Invest Ophthalmol Vis Sci 48:789-96. 2007
    ..The purpose of this study was to determine whether HSV-1 infection of human corneal epithelial (HCE) cells alone induces an early proapoptotic response and whether this response is subsequently downregulated during the infection...
  67. ncbi Differences in clinical parameters and tear film of tolerant and intolerant contact lens wearers
    Melissa J Glasson
    Co operative Research Centre for Eye Research and Technology, School of Optometry and Vision Science, University of New South Wales, Kensington, NSW 2052, Australia
    Invest Ophthalmol Vis Sci 44:5116-24. 2003
    ..To determine whether intolerance to contact lens wear is attributable to clinical or protein characteristics of the tear film...
  68. ncbi Betaine stabilizes cell volume and protects against apoptosis in human corneal epithelial cells under hyperosmotic stress
    Qian Garrett
    Brien Holden Vision Institute, Sydney, Australia
    Exp Eye Res 108:33-41. 2013
    ..We demonstrated that the transport of betaine was facilitated by increased osmolarity. In conclusion, betaine stabilized corneal epithelial cell volume under hyperosmotic stress and limited hyperosmotic stress-induced HCLE apoptosis...
  69. pmc Immobilization of antibacterial dihydropyrrol-2-ones on functional polymer supports to prevent bacterial infections in vivo
    Kitty Ka Kit Ho
    School of Chemistry, University of New South Wales, Sydney, NSW, Australia
    Antimicrob Agents Chemother 56:1138-41. 2012
    ..Covalently bound DHPs therefore show great potential for use as an antimicrobial strategy in device-related applications...
  70. ncbi Surface protein profile of extended-wear silicon hydrogel lenses
    Damon Pearce
    Cooperative Research Centre for Eye Research and Technology, University of New South Wales, Sydney, Australia
    Adv Exp Med Biol 506:957-60. 2002
  71. pmc Advanced glycation end product (AGE) modified proteins in tears of diabetic patients
    Zhenjun Zhao
    Brien Holden Vision Institute, Sydney, NSW 2052, Australia
    Mol Vis 16:1576-84. 2010
    ..This study investigated AGE modified proteins in tears and compared their levels in diabetic patients (DM) with non-diabetic controls (CTL)...
  72. doi Carboxymethyl cellulose stimulates rabbit corneal epithelial wound healing
    Qian Garrett
    Institute for Eye Research, Sydney, New South Wales, Australia
    Curr Eye Res 33:567-73. 2008
    ..Using an animal model, the efficacy of CMC in promoting corneal wound healing was examined...
  73. ncbi Influence of tear film and contact lens osmolality on ocular comfort in contact lens wear
    Ulrike Stahl
    The Vision Cooperative Research Centre, Sydney, New South Wales, Australia
    Optom Vis Sci 86:857-67. 2009
    ..To evaluate a novel method to measure the osmolality of worn contact lenses and assess the impact of contact lens and tear film osmolality on comfort during short-term wear...
  74. doi IgE antibody on worn highly oxygen-permeable silicone hydrogel contact lenses from patients with contact lens-induced papillary conjunctivitis (CLPC)
    Zhenjun Zhao
    Vision Cooperative Research Centre, Sydney, Australia
    Eye Contact Lens 34:117-21. 2008
    ....
  75. doi Divalent cations in tears, and their influence on tear film stability in humans and rabbits
    Xiaojia Eric Wei
    Brien Holden Vision Institute and School of Optometry and Vision Science, University of New South Wales, Sydney NSW 2052, Australia
    Invest Ophthalmol Vis Sci 53:3280-5. 2012
    ..Rabbits are known to have a more stable tear film than humans. Thus, we sought to examine the tears of rabbits and humans for metal cations, and to test how they influence tear film stability...
  76. doi Review of resistance of ocular isolates of Pseudomonas aeruginosa and staphylococci from keratitis to ciprofloxacin, gentamicin and cephalosporins
    Mark D P Willcox
    School of Optometry and Vision Science, University of New South Wales, Sydney NSW 2052, Australia
    Clin Exp Optom 94:161-8. 2011
    ..Antibiotic therapy to treat keratitis caused by these bacteria is either monotherapy with a fluoroquinolone or combination therapy with fortified gentamicin...
  77. pmc Mucin degradation mechanisms by distinct Pseudomonas aeruginosa isolates in vitro
    Lina Panayiota Aristoteli
    Cooperative Research Centre for Eye Research and Technology, University of New South Wales, Sydney 2052, Australia
    Infect Immun 71:5565-75. 2003
    ..It is postulated that the degradation of mucin serves to collapse the mucin barrier and its associated network containing antibacterial tear components and to provide energy for sustained bacterial growth...
  78. ncbi Clinical characterization of corneal infiltrative events observed with soft contact lens wear
    Deborah F Sweeney
    Cornea and Contact Lens Research Unit, School of Optometry and Vision Science, and The Cooperative Research Center for Eye Research and Technology, The University of New South Wales, Sydney, Australia
    Cornea 22:435-42. 2003
    ..The aim of this paper is to categorize corneal infiltrates associated with soft lens wear and present the typical clinical characteristics associated with each type of event...
  79. doi Tear lipocalin is the predominant phosphoprotein in human tear fluid
    Zhenjun Zhao
    Institute for Eye Research, Sydney, Australia
    Exp Eye Res 90:344-9. 2010
    ..These results indicate that tear lipocalin is the predominant phosphoprotein in normal human basal tears. Nucleobindin-2, prolactin-induced protein and lipophilin C also appear to be phosphorylated in basal tear samples...
  80. ncbi Proteomic analysis of dog tears for potential cancer markers
    Carla de Freitas Campos
    Institute for Eye Research, Rupert Myers Building, The University of New South Wales, Kensington, NSW 2052, Australia
    Res Vet Sci 85:349-52. 2008
    ..These findings suggest that it may be possible to develop tear film analysis to provide a simple non-invasive test for the diagnosis and/or management of canine cancers...
  81. ncbi Bacterial populations on high-Dk silicone hydrogel contact lenses: effect of length of wear in asymptomatic patients
    Mark D P Willcox
    School of Optometry and Vision Science, Cooperative Research Centre for Eye Research and Technology, The University of New South Wales, Sydney, NSW, 2052, Australia
    Clin Exp Optom 85:172-5. 2002
    ..This study examines the colonisation of a high-Dk silicone hydrogel contact lens worn on a 30-night extended wear basis (continuous wear) during asymptomatic lens wear...
  82. ncbi Determination of quorum-sensing signal molecules and virulence factors of Pseudomonas aeruginosa isolates from contact lens-induced microbial keratitis
    Hua Zhu
    Cooperative Research Center for Eye Research and Technology, University of New South Wales, UNSW, Sydney, NSW 2052, Australia
    J Med Microbiol 51:1063-70. 2002
    ..These results suggest that quorum-sensing systems of P. aeruginosa display a complexity even within the same species, and the production of certain AHL signal molecules may be associated with certain phenotypes in P. aeruginosa...
  83. ncbi Pseudomonas aeruginosa keratitis in IL-6-deficient mice
    Nerida Cole
    Co operative Research Centre for Eye Research and Technology, Cornea and Contact Lens Research Unit and School of Optometry, University of New South Wales, Sydney, Australia
    Int Arch Allergy Immunol 130:165-72. 2003
    ..Using IL-6-/- mice, we have explored the role of IL-6 in P. aeruginosa keratitis...
  84. pmc Intrinsic protein fluorescence interferes with detection of tear glycoproteins in SDS-polyacrylamide gels using extrinsic fluorescent dyes
    Zhenjun Zhao
    The Institute for Eye Research, North Wing, Rupert Myers Building, Gate 14, Barker St, UNSW Sydney, NSW 2052, Australia
    J Biomol Tech 18:331-5. 2007
    ..Nanograms of proteins gave visible native fluorescence and interfere with extrinsic fluorescent dye detection. Poly-L-lysine, which does not contain intrinsically fluorescent amino acids, did not fluoresce...
  85. ncbi Evasion of cellular ocular defenses by contact lens isolates of Serratia marcescens
    Emma B H Hume
    Cooperative Research Centre for Eye Research and Technology, University of South Wales, Sydney, Australia
    Eye Contact Lens 29:108-12. 2003
    ..The aim of this study was to investigate the interaction of S. marcescens with polymorphonuclear leukocytes (PMNs), which occur in closed-eye tears...
  86. ncbi Contact lens-induced papillary conjunctivitis is associated with increased albumin deposits on extended wear hydrogel lenses
    Maxine E Tan
    Cooperative Research Centre for Eye Research and Technology, University of New South Wales, Sydney, Australia
    Adv Exp Med Biol 506:951-5. 2002
  87. ncbi Corneal ulceration in pediatric patients: a brief overview of progress in topical treatment
    Serina Stretton
    The Cornea and Contact Lens Research Unit, The School of Optometry, The University of New South Wales, Sydney, NSW 2052, Australia
    Paediatr Drugs 4:95-110. 2002
    ....
  88. ncbi Mechanisms of apoptosis in human corneal epithelial cells
    Fiona Stapleton
    Cooperative Research Centre for Eye Research and Technology, The University of New South Wales, Sydney, Australia
    Adv Exp Med Biol 506:827-34. 2002
  89. ncbi Proteomic comparison of membrane and extracellular proteins from invasive (PAO1) and cytotoxic (6206) strains of Pseudomonas aeruginosa
    Amanda S Nouwens
    Australian Proteome Analysis Facility, Sydney, Australia
    Proteomics 2:1325-46. 2002
    ..These studies will aid in elucidating the differences between invasive and cytotoxic P. aeruginosa at the proteome level...
  90. ncbi Menopause, hormone replacement therapy and tear function
    Victoria Evans
    Cooperative Research Centre for Eye Research and Technology, The University of New South Wales, Kensington, NSW, Australia
    Adv Exp Med Biol 506:1029-33. 2002
  91. ncbi Which is more important to the initiation of contact lens related microbial keratitis, trauma to the ocular surface or bacterial pathogenic factors?
    Mark D P Willcox
    Clin Exp Optom 89:277-9. 2006
  92. ncbi The effect of protein-coated contact lenses on the adhesion and viability of gram negative bacteria
    Timothy J Williams
    Cooperative Research Centre for Eye Research and Technology, School of Optometry and Vision Science, Australia
    Curr Eye Res 27:227-35. 2003
    ..During contact lens wear, components of the tear film adsorb to the contact lens. This study aimed to investigate the effect of this conditioning film on the viability of bacteria...