M D Willcox

Summary

Affiliation: University of New South Wales
Country: Australia

Publications

  1. ncbi request reprint Potential sources of bacteria that are isolated from contact lenses during wear
    M D Willcox
    School of Optometry and Cooperative Research Centre for Eye Research and Technology, University of New South Wales, Sydney, Australia
    Optom Vis Sci 74:1030-8. 1997
  2. ncbi request reprint Streptococcus australis sp. nov., a novel oral streptococcus
    M D Willcox
    Centre for Eye Research and Technology CRCERT, University of New South Wales, Sydney, Australia
    Int J Syst Evol Microbiol 51:1277-81. 2001
  3. ncbi request reprint Bacterial interactions with contact lenses; effects of lens material, lens wear and microbial physiology
    M D Willcox
    Co operatiue Research Centre for Eye Research and Technology, University of New South Wales, Sydney, Australia
    Biomaterials 22:3235-47. 2001
  4. ncbi request reprint Expression of macrophage migration inhibitory factor during Pseudomonas keratitis
    A Thakur
    Cooperative Research Centre for Eye Research and Technology, The University of New South Wales, Sydney, Australia
    Clin Experiment Ophthalmol 29:179-82. 2001
  5. ncbi request reprint Tear changes in contact lens wearers following overnight eye closure
    F Stapleton
    Cornea and Contact Lens Research Unit, School of Optometry, University of New South Wales, Sydney, Australia
    Curr Eye Res 17:183-8. 1998
  6. ncbi request reprint Staphylococcus aureus causes acute inflammatory episodes in the cornea during contact lens wear
    P Z Wu
    Cooperative Research Centre for Eye Research and Technology, and Cornea and Contact Lens Research Unit, School of Optometry, University of New South Wales, Sydney, Australia
    Clin Experiment Ophthalmol 28:194-6. 2000
  7. ncbi request reprint Effect of hydrogel lens wear on the major tear proteins during extended wear
    F P Carney
    Cooperative Research Centre for Eye Research and Technology, University of New South Wales, Sydney, Australia
    Aust N Z J Ophthalmol 25:S36-8. 1997
  8. ncbi request reprint Detection of staphylococcal superantigens from contact-lens-induced inflammatory diseases
    H Zhu
    Cooperative Research Centre for Eye Research and Technology, The University of New South Wales, Sydney, Australia
    Aust N Z J Ophthalmol 27:237-40. 1999
  9. ncbi request reprint Differences in the pathogenesis of bacteria isolated from contact-lens-induced infiltrative conditions
    M D Willcox
    Cooperative Research Centre for Eye Research and Technology, School of Optometry, University of New South Wales, Sydney, Australia
    Aust N Z J Ophthalmol 27:231-3. 1999
  10. ncbi request reprint Serotype and adhesion of Pseudomonas aeruginosa isolated from contact lens wearers
    S J Thuruthyil
    Cooperative Research Centre for Eye Research and Technology, The University of New South Wales, Sydney, Australia
    Clin Experiment Ophthalmol 29:147-9. 2001

Collaborators

Detail Information

Publications33

  1. ncbi request reprint Potential sources of bacteria that are isolated from contact lenses during wear
    M D Willcox
    School of Optometry and Cooperative Research Centre for Eye Research and Technology, University of New South Wales, Sydney, Australia
    Optom Vis Sci 74:1030-8. 1997
    ..The aim of this paper was to determine the possible contamination sources of contact lenses during wear...
  2. ncbi request reprint Streptococcus australis sp. nov., a novel oral streptococcus
    M D Willcox
    Centre for Eye Research and Technology CRCERT, University of New South Wales, Sydney, Australia
    Int J Syst Evol Microbiol 51:1277-81. 2001
    ..The name Streptococcus australis sp. nov. is proposed for the new species. The type strain is AI-1T (= ATCC 700641T = NCTC 13166T)...
  3. ncbi request reprint Bacterial interactions with contact lenses; effects of lens material, lens wear and microbial physiology
    M D Willcox
    Co operatiue Research Centre for Eye Research and Technology, University of New South Wales, Sydney, Australia
    Biomaterials 22:3235-47. 2001
    ..aeruginosa Paerl. Thus, these surface changes would have been likely to have mediated the increased adhesion to Etafilcon A contact lenses...
  4. ncbi request reprint Expression of macrophage migration inhibitory factor during Pseudomonas keratitis
    A Thakur
    Cooperative Research Centre for Eye Research and Technology, The University of New South Wales, Sydney, Australia
    Clin Experiment Ophthalmol 29:179-82. 2001
    ..High expression of MIF in the infected corneas suggests that it may have a role in the pathogenesis of corneal disease induced by invasive and cytotoxic strains of P. aeruginosa...
  5. ncbi request reprint Tear changes in contact lens wearers following overnight eye closure
    F Stapleton
    Cornea and Contact Lens Research Unit, School of Optometry, University of New South Wales, Sydney, Australia
    Curr Eye Res 17:183-8. 1998
    ..Since overnight wear of contact lenses (CLs) is associated with an increased risk of corneal infection and inflammation, this study aimed to quantify tear protein changes with overnight soft CL wear...
  6. ncbi request reprint Staphylococcus aureus causes acute inflammatory episodes in the cornea during contact lens wear
    P Z Wu
    Cooperative Research Centre for Eye Research and Technology, and Cornea and Contact Lens Research Unit, School of Optometry, University of New South Wales, Sydney, Australia
    Clin Experiment Ophthalmol 28:194-6. 2000
    ..Contact lens wear also prolonged the retention of bacteria in the eye. Extended contact lens wear and S. aureus caused non-ulcerative keratitis in a rabbit model, and disturbances in the ability of the eye to remove bacteria...
  7. ncbi request reprint Effect of hydrogel lens wear on the major tear proteins during extended wear
    F P Carney
    Cooperative Research Centre for Eye Research and Technology, University of New South Wales, Sydney, Australia
    Aust N Z J Ophthalmol 25:S36-8. 1997
    ..The purpose of the present study was to determine the whether contact lens wear disturbed the levels of tear proteins and to further determine whether this was a transient or continuous disruption...
  8. ncbi request reprint Detection of staphylococcal superantigens from contact-lens-induced inflammatory diseases
    H Zhu
    Cooperative Research Centre for Eye Research and Technology, The University of New South Wales, Sydney, Australia
    Aust N Z J Ophthalmol 27:237-40. 1999
    ..We investigated the correlation between the production of superantigens in Staphylococcus-aureus-induced ulcer and contact-lens-induced peripheral ulcer (CLPU) and infiltrative keratitis (IK)...
  9. ncbi request reprint Differences in the pathogenesis of bacteria isolated from contact-lens-induced infiltrative conditions
    M D Willcox
    Cooperative Research Centre for Eye Research and Technology, School of Optometry, University of New South Wales, Sydney, Australia
    Aust N Z J Ophthalmol 27:231-3. 1999
    ..The purpose of this study was to examine the ability of gram-negative bacteria isolated from the non-infectious condition contact-lens-induced acute red eye (CLARE) and infectious microbial keratitis (MK) to infect the eyes of mice...
  10. ncbi request reprint Serotype and adhesion of Pseudomonas aeruginosa isolated from contact lens wearers
    S J Thuruthyil
    Cooperative Research Centre for Eye Research and Technology, The University of New South Wales, Sydney, Australia
    Clin Experiment Ophthalmol 29:147-9. 2001
    ..These results indicate that the surface characteristics of bacterial serotypes are related to the bacterial adhesion to the surface, but the pathogenesis of the bacteria may result from multiple factors...
  11. ncbi request reprint Contact lens wear alters the production of certain inflammatory mediators in tears
    A Thakur
    Co operative Research Centre for Eye Research and Technology, The University of New South Wales, Sydney, NSW, 2052, Australia
    Exp Eye Res 70:255-9. 2000
    ..However, this alteration changes from NACLW to ACLW. This may have effects on the ability of the eye to defend itself during contact lens wear...
  12. ncbi request reprint Comparison of potential pathogenic traits of staphylococci that may contribute to corneal ulceration and inflammation
    P Z Wu
    Cooperative Research Centre for Eye Research and Technology, School of Optometry, University of New South Wales, Sydney, Australia
    Aust N Z J Ophthalmol 27:234-6. 1999
    ..This study has demonstrated that S. aureus is better equipped with a range of potentially damaging enzymes and toxins than S. epidermidis and that S. aureus elastase may be involved in the production of corneal ulcers...
  13. ncbi request reprint Albumin-binding proteins on the surface of the Streptococcus milleri group and characterization of the albumin receptor of Streptococcus intermedius C5
    M D Willcox
    Institute of Dental Research, United Dental Hospital, Sydney, NSW, Australia
    J Gen Microbiol 139:2451-8. 1993
    ..The receptor was physically dissimilar from protein G, an albumin- and IgG-binding protein of 'large-colony' Lancefield group C and G streptococci...
  14. ncbi request reprint Effect of tear-specific immunoglobulin A on the adhesion of Pseudomonas aeruginosa I to contact lenses
    J Lan
    Cooperative Research Centre for Eye Research and Technology, University of New South Wales, Sydney, New South Wales, Australia
    Aust N Z J Ophthalmol 27:218-20. 1999
    ..The aims of the study were (i) to determine the immunodominant antigens of Pseudomonos aeruginoso 1 (Paer1) to tear secretory immunoglobulin A (sIgA); (ii) to study the role of sIgA in inhibiting bacterial adhesion to contact lenses...
  15. ncbi request reprint Effect of tear secretory IgA on chemotaxis of polymorphonuclear leucocytes
    J X Lan
    Cooperative Research Centre for Eye Research and Technology, School of Microbiology and Immunology, University of New South Wales, Sydney, Australia
    Aust N Z J Ophthalmol 26:S36-9. 1998
    ..The aim of the present study was to examine the effect of tear and purified colostrum secretory IgA (sIgA) on polymorphonuclear leucocyte (PMN) chemotaxis...
  16. ncbi request reprint Microbial colonization of soft contact lenses over time
    D F Sweeney
    Cornea and Contact Lens Research Unit, School of Optometry and Cooperative Research Centre for Eye Research and Technology, University of New South Wales, Sydney, Australia
    Optom Vis Sci 78:100-5. 2001
    ..Gram-positive bacteria were isolated frequently but in low numbers, whereas gram-negative bacteria were present sporadically...
  17. ncbi request reprint Production of N-acyl homoserine lactones by gram-negative bacteria isolated from contact lens wearers
    H Zhu
    Cooperative Research Centre for Eye Research and Technology, The University of New South Wales, Sydney, Australia
    Clin Experiment Ophthalmol 29:150-2. 2001
    ..These findings indicate that AHL-mediated quorum-sensing systems are present in some of the ocular bacteria, and the different signal molecules may be involved with the quorum-sensing pathway in the other bacterial species...
  18. ncbi request reprint Pro-inflammatory cytokine/chemokine gene expression in human corneal epithelial cells colonized by Pseudomonas aeruginosa
    M L Xue
    Cooperative Research Centre for Eye Research and Technology, School of Optometry, University of New South Wales, Sydney, Australia
    Clin Experiment Ophthalmol 28:197-200. 2000
    ..In conclusion, bacterial colonization of human corneal epithelial cells induced expression of IL-6 and IL-8 mRNA earlier and at higher levels than IL-1beta and TNF-alpha mRNA...
  19. ncbi request reprint Invasive strains of Pseudomonas aeruginosa are able to cause epithelial cell cytotoxicity that is dependent on bacterial cell density
    H Zhu
    Cooperative Research Center for Eye Research and Technology, University of New South Wales, Sydney, Australia
    Clin Experiment Ophthalmol 28:201-4. 2000
    ..95, P<0.05). These results indicate that the invasive strains regulate the production of virulence factors and, in turn, induce chronic dose-related cytotoxicity...
  20. ncbi request reprint Secretory IgA epitopes in basal tears of extended-wear soft contact lens wearers and in non-lens wearers
    D J Pearce
    The Cooperative Research Centre for Eye Research and Technology, Randwick, Sydney, New South Wales, Australia
    Aust N Z J Ophthalmol 27:221-3. 1999
    ..To determine secretory IgA epitopes in tears of extended-wear soft contact lens wearers and non-wearing controls...
  21. ncbi request reprint Random amplified polymorphic DNA analysis of Acinetobacter species isolated from worn contact lenses
    K M Corrigan
    Cooperative Research Centre for Eye Research and Technology, The University of New South Wales, Sydney, Australia
    Clin Experiment Ophthalmol 29:153-6. 2001
    ..These results indicate that many genotypes of Acinetobacter can cause adverse responses, and the initial source of the microorganisms rather than their clinical sequelae may determine classification...
  22. ncbi request reprint Effect of lysozyme on adhesion and toxin release by Staphylococcus aureus
    A Thakur
    Cornea and Contact Lens Research Unit, Cooperative Research Centre for Eye Research and Technology, University of New South Wales, Sydney, Australia
    Aust N Z J Ophthalmol 27:224-7. 1999
    ..We investigated the effect of the tear protein lysozyme on S. aureus adhesion to contact lenses and its effect on production of toxins or enzymes...
  23. pmc Effector mechanisms of protection against Pseudomonas aeruginosa keratitis in immunized rats
    A Thakur
    Cooperative Research Center for Eye Research and Technology, The University of New South Wales, Sydney, New South Wales 2052, Australia
    Infect Immun 69:3295-304. 2001
    ..This study has shown that the route of immunization modulates the inflammatory response to ocular P. aeruginosa infection, thus affecting the severity of keratitis and adverse pathology, with nasal immunization being the most effective...
  24. ncbi request reprint Association of acinetobacter species with contact lens-induced adverse responses
    K M Corrigan
    Cornea and Contact Lens Research Unit, School of Optometry, and The Cooperative Research Center for Eye Research and Technology, University of New South Wales, Sydney, Australia
    Cornea 20:463-6. 2001
    ..When Acinetobacter species were in high numbers on a contact lens, an adverse response occurred. This may implicate Acinetobacter species as a contributing factor to adverse responses associated with contact lens wear...
  25. ncbi request reprint Antimicrobial peptides: a potential role in ocular therapy
    Y Aliwarga
    Cooperative Research Centre for Eye Research and Technology, The University of New South Wales, Sydney, Australia
    Clin Experiment Ophthalmol 29:157-60. 2001
    ..Protamine alone and its combination with melittin may have potential therapeutic agents for ocular infections in an era of emerging antibiotic resistance...
  26. ncbi request reprint Does Acanthamoeba protect Pseudomonas aeruginosa from the bactericidal effects of contact lens disinfecting systems?
    M D Willcox
    School of Optometry, and Cooperative Research Centre for Eye Research and Technology, University of New South Wales, Sydney, Australia
    Aust N Z J Ophthalmol 26:S32-5. 1998
    ..The aim of this study was to test the hypothesis that Pseudomonas aeruginosa that have been internalized in Acanthamoeba are protected against the action of contact lens disinfecting solutions...
  27. ncbi request reprint Adhesion of Pseudomonas aeruginosa ocular isolates to mucin
    L P Aristoteli
    Cooperative Research Centre for Eye Research and Technology, The University of New South Wales, Sydney, Australia
    Clin Experiment Ophthalmol 29:143-6. 2001
    ..It is concluded that the adhesion of P. aeruginosa strains to mucin alone may not be a principal determinant of pathogenesis but may be a contributing factor along with other bacterial virulence traits...
  28. ncbi request reprint Regulatory role of IL-1beta in the expression of IL-6 and IL-8 in human corneal epithelial cells during Pseudomonas aeruginosa colonization
    M L Xue
    Cooperative Research Centre for Eye Research and Technology, The University of New South Wales, Sydney, Australia
    Clin Experiment Ophthalmol 29:171-4. 2001
    ..In conclusion, P. aeruginosa-colonized HCE cells produced low levels of IL-1beta and high levels of IL-6 and IL-8. Neutralizing IL-1beta protein significantly downregulated the production of IL-8 and IL-6...
  29. ncbi request reprint Protein microanalysis of animal tears
    S Hemsley
    Department of Veterinary Anatomy and Pathology, University of Sydney, Sydney, NSW, 2006, Australia
    Res Vet Sci 68:207-9. 2000
    ..75 microl) of tears. Their expansion could allow isola tion, identification and quantitation of individual tear components, enabling effective investigation of changes occurring in disease...
  30. ncbi request reprint Modulation of tear film protein secretion with phosphodiesterase inhibitors
    V Evans
    Cooperative Research Centre for Eye Research and Technology, University of New South Wales, Sydney, Australia
    Clin Experiment Ophthalmol 28:208-11. 2000
    ..The adverse symptomatology and increased conjunctival redness experienced with nicardipine make it an undesirable treatment for dry eye...
  31. ncbi request reprint Contact lens related corneal infections
    M D Willcox
    Co-operative Research Centre for Eye Research and Technology, School of Optometry, University of New South Wales, Sydney, Australia
    Biosci Rep 21:445-61. 2001
    ..The microbial, biochemical and immunological aspects of MK will be described in detail...
  32. ncbi request reprint Lacryglobin in human tears, a potential marker for cancer
    V Evans
    Cooperative Research Centre for Eye Research and Technology, School of Optometry, University of New South Wales, Sydney, Australia
    Clin Experiment Ophthalmol 29:161-3. 2001
    ..Two control patients with lacryglobin had a family history of breast and prostate cancer. Lacryglobin was detected in some but not all tear samples and further studies are warranted to investigate its potential as a marker for cancer...
  33. ncbi request reprint Establishment of the human reflex tear two-dimensional polyacrylamide gel electrophoresis reference map: new proteins of potential diagnostic value
    M P Molloy
    Australian Proteome Analysis Facility, Macquarie University, Sydney
    Electrophoresis 18:2811-5. 1997
    ..This protein displays strong homology with mammaglobin, a protein overexpressed in breast cancer. The discovery of this homologue in tears offers the potential for disease diagnosis by screening tear fluid proteins...