I M Whyte

Summary

Affiliation: University of Newcastle
Country: Australia

Publications

  1. ncbi request reprint Relative toxicity of venlafaxine and selective serotonin reuptake inhibitors in overdose compared to tricyclic antidepressants
    I M Whyte
    School of Population Health Sciences, Faculty of Medicine and Health Sciences, University of Newcastle, and Department of Clinical Toxicology and Pharmacology, Newcastle Mater Misericordiae Hospital, NSW, Australia
    QJM 96:369-74. 2003
  2. ncbi request reprint Data collection in clinical toxicology: are there too many variables?
    Ian M Whyte
    Faculty of Medicine and Health Sciences, School of Population Health Sciences, University of Newcastle, New South Wales, Australia
    J Toxicol Clin Toxicol 40:223-30. 2002
  3. ncbi request reprint Introduction: research in clinical toxicology--the value of high quality data
    Ian M Whyte
    Faculty of Medicine and Health Sciences, School of Population Health Sciences, University of Newcastle, New South Wales, Australia
    J Toxicol Clin Toxicol 40:211-2. 2002
  4. ncbi request reprint Health care. A model for the management of self-poisoning
    I M Whyte
    Newcastle Mater Misericordiac Hospital, NSW
    Med J Aust 167:142-6. 1997
  5. ncbi request reprint Lithium: thyroid effects and altered renal handling
    P W Oakley
    Department of Clinical Toxicology and Pharmacology, Newcastle Mater Misericordiae Hospital, Hunter Regional Mail Center, Australia
    J Toxicol Clin Toxicol 38:333-7. 2000
  6. ncbi request reprint Pheniramine--a much abused drug
    N A Buckley
    Department of Clinical Pharmacology and Toxicology, Newcastle Mater Misericordiae Hospital, Waratah, NSW
    Med J Aust 160:188-92. 1994
  7. pmc Therapeutic drug monitoring in drug overdose
    A H Dawson
    Department of Clinical Toxicology and Pharmacology, Newcastle Mater Hospital, Locked Bag 7, Hunter Regional Mail Centre, NSW 2310, Australia
    Br J Clin Pharmacol 48:278-83. 1999
  8. ncbi request reprint Repetition of deliberate self-poisoning in an Australian hospital-treated population
    G L Carter
    Newcastle Mater Misericordiae Hospital, Waratah, NSW
    Med J Aust 170:307-11. 1999
  9. ncbi request reprint Greater toxicity in overdose of dothiepin than of other tricyclic antidepressants
    N A Buckley
    Department of Clinical Pharmacology and Toxicology, Mater Misericordlae Hospital, Newcastle, NSW, Australia
    Lancet 343:159-62. 1994
  10. ncbi request reprint Interrater agreement in the measurement of QRS interval in tricyclic antidepressant overdose: implications for monitoring and research
    N A Buckley
    University of Newcastle, Australia
    Ann Emerg Med 28:515-9. 1996

Collaborators

Detail Information

Publications46

  1. ncbi request reprint Relative toxicity of venlafaxine and selective serotonin reuptake inhibitors in overdose compared to tricyclic antidepressants
    I M Whyte
    School of Population Health Sciences, Faculty of Medicine and Health Sciences, University of Newcastle, and Department of Clinical Toxicology and Pharmacology, Newcastle Mater Misericordiae Hospital, NSW, Australia
    QJM 96:369-74. 2003
    ..Selective serotonin reuptake inhibitors (SSRIs) and venlafaxine have been regarded as less toxic in overdose than tricyclic antidepressants (TCAs). Within the TCAs, dothiepin has greater toxicity. Venlafaxine may be more toxic than SSRIs...
  2. ncbi request reprint Data collection in clinical toxicology: are there too many variables?
    Ian M Whyte
    Faculty of Medicine and Health Sciences, School of Population Health Sciences, University of Newcastle, New South Wales, Australia
    J Toxicol Clin Toxicol 40:223-30. 2002
    ..In the area of research, an appropriately designed database can be both a source of hypotheses as well as a vehicle to test them. It can also serve as a repository of research data in subsequent randomized controlled trials...
  3. ncbi request reprint Introduction: research in clinical toxicology--the value of high quality data
    Ian M Whyte
    Faculty of Medicine and Health Sciences, School of Population Health Sciences, University of Newcastle, New South Wales, Australia
    J Toxicol Clin Toxicol 40:211-2. 2002
  4. ncbi request reprint Health care. A model for the management of self-poisoning
    I M Whyte
    Newcastle Mater Misericordiac Hospital, NSW
    Med J Aust 167:142-6. 1997
    ..To describe the development and activity of a multidisciplinary service to manage self-poisoning...
  5. ncbi request reprint Lithium: thyroid effects and altered renal handling
    P W Oakley
    Department of Clinical Toxicology and Pharmacology, Newcastle Mater Misericordiae Hospital, Hunter Regional Mail Center, Australia
    J Toxicol Clin Toxicol 38:333-7. 2000
    ..Thyroxine, through its effects on tubular function, alters lithium clearance such that thyroid disease may cause retention of lithium and subsequent toxicity...
  6. ncbi request reprint Pheniramine--a much abused drug
    N A Buckley
    Department of Clinical Pharmacology and Toxicology, Newcastle Mater Misericordiae Hospital, Waratah, NSW
    Med J Aust 160:188-92. 1994
    ..To assess the relative clinical toxicity of pheniramine compared with other antihistamines taken in overdose and its relative use for self-poisoning...
  7. pmc Therapeutic drug monitoring in drug overdose
    A H Dawson
    Department of Clinical Toxicology and Pharmacology, Newcastle Mater Hospital, Locked Bag 7, Hunter Regional Mail Centre, NSW 2310, Australia
    Br J Clin Pharmacol 48:278-83. 1999
    ..Drug concentrations are particularly important for those compounds where the concentration is predictive of serious toxicity in an otherwise asymptomatic patient...
  8. ncbi request reprint Repetition of deliberate self-poisoning in an Australian hospital-treated population
    G L Carter
    Newcastle Mater Misericordiae Hospital, Waratah, NSW
    Med J Aust 170:307-11. 1999
    ..To describe the hospital-treated prevalences for repeat deliberate self-poisoning (RDSP) and the demographic characteristics of the RDSP group, and to compare the RDSP and non-RDSP groups...
  9. ncbi request reprint Greater toxicity in overdose of dothiepin than of other tricyclic antidepressants
    N A Buckley
    Department of Clinical Pharmacology and Toxicology, Mater Misericordlae Hospital, Newcastle, NSW, Australia
    Lancet 343:159-62. 1994
    ..Consideration should be given to the use of other antidepressants in patients at risk of seizures or suicide. Regulatory authorities should review the need for a 75 mg strength tablet of any TCA...
  10. ncbi request reprint Interrater agreement in the measurement of QRS interval in tricyclic antidepressant overdose: implications for monitoring and research
    N A Buckley
    University of Newcastle, Australia
    Ann Emerg Med 28:515-9. 1996
    ..To assess interobserver agreement when experienced clinicians measure QRS-interval duration in tricyclic antidepressant (TCA) overdose...
  11. doi request reprint Oxycodone overdose causes naloxone responsive coma and QT prolongation
    I Berling
    Department of Clinical Toxicology and Pharmacology, Calvary Mater Newcastle, Waratah, NSW, Australia
    QJM 106:35-41. 2013
    ..Given the high prescription rate and increasing use of oxycodone, an understanding of its effects and treatment in overdose is necessary...
  12. ncbi request reprint Lithium toxicity: an iatrogenic problem in susceptible individuals
    P W Oakley
    Department of Medicine, Newcastle Mater Misericordiae Hospital, NSW, Australia
    Aust N Z J Psychiatry 35:833-40. 2001
    ..Furthermore we hypothesized that patients who developed chronic poisoning did so in the presence of identifiable factors which predictably impair lithium clearance...
  13. ncbi request reprint The Hunter Serotonin Toxicity Criteria: simple and accurate diagnostic decision rules for serotonin toxicity
    E J C Dunkley
    School of Medical Practice and Population Health, University of Newcastle, Newcastle, NSW, Australia
    QJM 96:635-42. 2003
    ..There are difficulties with the diagnosis of serotonin toxicity, particularly with the use of Sternbach's criteria...
  14. doi request reprint Promethazine overdose: clinical effects, predicting delirium and the effect of charcoal
    C B Page
    Department of Clinical Toxicology and Pharmacology, Calvary Mater Newcastle, NSW 2310, Australia
    QJM 102:123-31. 2009
    ..The aim of this study was to describe the clinical effects of promethazine in overdose and explore the relationship between delirium and possible predictor variables...
  15. ncbi request reprint Suspected white-tail spider bite and necrotic ulcers
    G K Isbister
    Discipline of Clinical Pharmacology, University of Newcastle, Newcastle Mater Misericordiae Hospital, Waratah, NSW 2298, Australia
    Intern Med J 34:38-44. 2004
    ..To describe the clinical features, investigation, diagnosis and treatment of ulcers attributed to white-tail (WT) spider bites or necrotic arachnidism...
  16. pmc Therapeutic drug monitoring in drug overdose
    A H Dawson
    Department of Clinical Toxicology and Pharmacology, Newcastle Mater Hospital, Hunter Regional Mail Centre, NSW 2310, Australia
    Br J Clin Pharmacol 52:97S-102S. 2001
    ..Drug concentrations are particularly important for those compounds where the concentration is predictive of serious toxicity in an otherwise asymptomatic patient...
  17. ncbi request reprint QTc abnormalities in deliberate self-poisoning with moclobemide
    M A Downes
    Department of Clinical Toxicology and Pharmacology, Newcastle Mater Hospital, New South Wales, Australia
    Intern Med J 35:388-91. 2005
    ..Several medications have been found to prolong the QT interval in overdose. This can predispose to torsade de pointes-type ventricular tachycardia...
  18. ncbi request reprint Management of dapsone poisoning complicated by methaemoglobinaemia
    A H Dawson
    Royal Newcastle Hospital, NSW, Australia
    Med Toxicol Adverse Drug Exp 4:387-92. 1989
    ..The principles of treatment of methaemoglobinaemia due to dapsone can be applied to methaemoglobinaemia due to any agent producing prolonged oxidative stress...
  19. pmc Feasibility of prehospital treatment with activated charcoal: Who could we treat, who should we treat?
    G K Isbister
    Newcastle Mater Misericordiae Hospital, University of Newcastle, Waratah, Australia
    Emerg Med J 20:375-8. 2003
    ..To investigate the feasibility and potential risk benefit of prehospital administration of activated charcoal...
  20. ncbi request reprint Clinical management for hospital-treated deliberate self-poisoning: comparisons between patients with major depression and borderline personality disorder
    Gregory L Carter
    Faculty of Health, University of Newcastle, Callaghan, NSW, Australia
    Aust N Z J Psychiatry 39:266-73. 2005
    ....
  21. ncbi request reprint Posttraumatic stress disorder among deliberate self-poisoning patients
    Kerrie Clover
    Consultation Liaison Psychiatry, Newcastle Mater Hospital, Newcastle, Australia
    J Trauma Stress 17:509-17. 2004
    ..Logistic regression modeling showed that PTSD was associated with the type of traumatic event, number of events, affective disorder, and anxiety disorder other than PTSD...
  22. ncbi request reprint Psychiatric hospitalization after deliberate self-poisoning
    Gregory L Carter
    Suicide Prevention Research Unit, Centre for Mental Health Studies at the University of Newcastle and Hunter and New England Area Health Service, Australia
    Suicide Life Threat Behav 36:213-22. 2006
    ..Recommendation for psychiatric hospitalization was based on complex decision making. These findings have implications for clinical practice guidelines, service costs, and service organization...
  23. ncbi request reprint Postcards from the EDge: 24-month outcomes of a randomised controlled trial for hospital-treated self-poisoning
    Gregory L Carter
    Department of Consultation Liaison Psychiatry, Locked Bag 7, Hunter Region Mail Centre, NSW 2310, Australia
    Br J Psychiatry 191:548-53. 2007
    ..Repetition of self-poisoning is common...
  24. ncbi request reprint Non-suicidal deaths following hospital-treated self-poisoning
    Greg Carter
    Children s Pavillion, Dunedin Public Hospital, Dunedin, New Zealand
    Aust N Z J Psychiatry 39:101-7. 2005
    ..To quantify the non-suicidal mortality subsequent to hospital treated self-poisoning, and to identify risk factors for non-suicidal death...
  25. ncbi request reprint Repeated self-poisoning: increasing severity of self-harm as a predictor of subsequent suicide
    Greg Carter
    Faculty of Medicine and Health Services, Suicide Prevention Research Unit, Centre for Mental Health Studies, University of Newcastle, Newcastle, New South Wales, Australia
    Br J Psychiatry 186:253-7. 2005
    ..Prediction of suicide risk is difficult in clinical practice...
  26. pmc Postcards from the EDge project: randomised controlled trial of an intervention using postcards to reduce repetition of hospital treated deliberate self poisoning
    Gregory L Carter
    Suicide Prevention Research Unit, Centre for Mental Health Studies, Faculty of Health, University of Newcastle, Newcastle, Australia
    BMJ 331:805. 2005
    ..To determine whether an intervention using postcards (postcards from the EDge project) reduces repetitions of hospital treated deliberate self poisoning...
  27. ncbi request reprint Diagnostic data in clinical toxicology--should we use a Bayesian approach?
    Nicholas A Buckley
    Clinical Pharmacology and Toxicology, The Canberra Hospital, Woden, Australian Capital Territory, Australia
    J Toxicol Clin Toxicol 40:213-22. 2002
    ..The usefulness (i.e., external validity) of clinical research from other centers can also be determined...
  28. ncbi request reprint Atypical presentation of risperidone toxicity
    Geoffrey K Isbister
    Vet Hum Toxicol 44:118-9; author reply 119. 2002
  29. ncbi request reprint Serotonin toxicity with therapeutic doses of dexamphetamine and venlafaxine
    Felicity H Prior
    Med J Aust 176:240-1. 2002
  30. ncbi request reprint Baclofen overdose: defining the spectrum of toxicity
    Nicola Y Leung
    Department of Clinical Toxicology and Pharmacology, Newcastle Mater Misericordiae Hospital, Waratah, New South Wales, Australia
    Emerg Med Australas 18:77-82. 2006
    ..To describe the spectrum of toxicity of baclofen in overdose, and investigate dose-related clinical effects...
  31. ncbi request reprint Paracetamol recall: a natural experiment influencing analgesic poisoning
    Corrine R Balit
    NSW Poisons Information Centre, The Children s Hospital, Westmead
    Med J Aust 176:162-5. 2002
    ..To determine whether the occurrence of paracetamol and non-paracetamol analgesic deliberate self-poisoning (DSP) and accidental paediatric poisoning was affected by two periods of recall of paracetamol products...
  32. ncbi request reprint Development of a Chinese herbal medicine toxicology database
    Alan Bensoussan
    Research Unit for Complementary Medicine, University of Western Sydney, NSW, Australia
    J Toxicol Clin Toxicol 40:159-67. 2002
    ..The goals of this project were to retrieve and evaluate scientific evidence on the toxicity of Chinese herbal medicine, to grade the toxicity of individual herbs, and to summarize relevant herb data via a searchable electronic database...
  33. ncbi request reprint Chinese herbal medicine toxicology database: monograph on Herba Asari, "xi xin"
    Anna K Drew
    Department of Clinical Toxicology, Newcastle Mater Misericordiae Hospital, Australia
    J Toxicol Clin Toxicol 40:169-72. 2002
  34. ncbi request reprint Chinese herbal medicine toxicology database: monograph on Radix Sophorae Flavescentis, "ku shen"
    Anna K Drew
    Department of Clinical Toxicology, Newcastle Mater Misericordiae Hospital, Australia
    J Toxicol Clin Toxicol 40:173-6. 2002
  35. pmc Valproate overdose: a comparative cohort study of self poisonings
    Geoffrey K Isbister
    Discipline of Clinical Pharmacology, University of Newcastle, Level 5, Clinical Sciences Building, Newcastle Mater Misericordiae Hospital, Waratah, NSW 2298, Newcastle, Australia
    Br J Clin Pharmacol 55:398-404. 2003
    ..Based on individual case reports of massive overdoses, valproate is often regarded as having significant toxicity. This study aimed to describe the epidemiology of valproate poisoning and the spectrum of its clinical effects...
  36. ncbi request reprint Adolescent depression
    Patricia McGettigan
    N Engl J Med 348:473-4; author reply 473-4. 2003
  37. ncbi request reprint Relative toxicity of selective serotonin reuptake inhibitors (SSRIs) in overdose
    Geoffrey K Isbister
    Discipline of Clinical Pharmacology, University of Newcastle, Newcastle Mater Misericordiae Hospital, Waratah, New South Wales, Australia
    J Toxicol Clin Toxicol 42:277-85. 2004
    ..Objective: To determine the effect of SSRIs in overdose, as a group, and the relative toxicity of five different SSRIs...
  38. ncbi request reprint The effect of recalling paracetamol on hospital admissions for poisoning
    Corrine M Balit
    Med J Aust 179:221-2; author reply 223. 2003
  39. ncbi request reprint Olanzapine and serotonin toxicity
    Geoffrey K Isbister
    Psychiatry Clin Neurosci 57:241-2. 2003
  40. pmc Moclobemide poisoning: toxicokinetics and occurrence of serotonin toxicity
    Geoffrey K Isbister
    Discipline of Clinical Pharmacology, University of Newcastle, Newcastle, Australia
    Br J Clin Pharmacol 56:441-50. 2003
    ..To investigate the spectrum of toxicity of moclobemide overdose, the occurrence of serotonin toxicity, and to estimate toxicokinetic parameters...
  41. ncbi request reprint Presumed Angel's trumpet (Brugmansia) poisoning: clinical effects and epidemiology
    Geoffrey K Isbister
    Discipline of Clinical Pharmacology, University of Newcastle, Department of Clinical Toxicology and Pharmacology, Newcastle Mater Misericordiae Hospital, Newcastle, New South Wales, Australia
    Emerg Med (Fremantle) 15:376-82. 2003
    ..To investigate the pattern and epidemiology of anticholinergic plant poisoning, and to characterize its time course and clinical features...
  42. ncbi request reprint Adverse reactions to mirtazapine are unlikely to be serotonin toxicity
    Geoffrey K Isbister
    Clin Neuropharmacol 26:287-8; author reply 289-90. 2003
  43. ncbi request reprint Aspiration pneumonitis in an overdose population: frequency, predictors, and outcomes
    Geoffrey K Isbister
    Discipline of Clinical Pharmacology, University of Newcastle, Australia
    Crit Care Med 32:88-93. 2004
    ....
  44. ncbi request reprint Effect of paracetamol poisoning on international normalised ratio
    Ian M Whyte
    Lancet 361:429; author reply 429-30. 2003
  45. ncbi request reprint Arsenic trioxide poisoning: a description of two acute overdoses
    Geoffrey K Isbister
    Discipline of Clinical Pharmacology, University of Newcastle, Newcastle, NSW, Australia
    Hum Exp Toxicol 23:359-64. 2004
    ..Arsenic quantification in blood, urine and faeces suggested that enhanced gastrointestinal decontamination was minimally effective for decontamination and that DMSA for at least two weeks was required...
  46. ncbi request reprint Evidence in clinical toxicology: the role of therapeutic drug monitoring
    Andrew H Dawson
    Department of Clinical Toxicology and Pharmacology, University of Newcastle, Newcastle Mater Hospital, Newcastle, New South Wales, Australia
    Ther Drug Monit 24:159-62. 2002