Thomas J Whitford
Affiliation: University of Sydney
- Brain maturation in adolescence: concurrent changes in neuroanatomy and neurophysiologyThomas J Whitford
Brain Dynamics Centre, Westmead Millennium Institute, University of Sydney, Westmead Hospital, New South Wales, Australia
Hum Brain Mapp 28:228-37. 2007..We suggest that the reduction in gray matter primarily reflects a reduction of neuropil, and that the corresponding elimination of active synapses is responsible for the observed reduction in EEG power...
- Delusions and dorso-medial frontal cortex volume in first-episode schizophrenia: a voxel-based morphometry studyThomas J Whitford
The Brain Dynamics Centre, Westmead Millennium Institute and University of Sydney, Westmead, NSW, 2145, Australia
Psychiatry Res 172:175-9. 2009....
- Volumetric white matter abnormalities in first-episode schizophrenia: a longitudinal, tensor-based morphometry studyThomas J Whitford
Brain Dynamics Centre, Acacia House, Westmead Hospital, Westmead, NSW, 2145, Australia
Am J Psychiatry 164:1082-9. 2007....
- Progressive grey matter atrophy over the first 2-3 years of illness in first-episode schizophrenia: a tensor-based morphometry studyThomas J Whitford
The Brain Dynamics Centre, Westmead Millennium Institute and University of Sydney, Acacia House, Westmead Hospital, NSW 2145, Australia
Neuroimage 32:511-9. 2006..We argue that the progressive GM atrophy we have found to be associated with the onset of schizophrenia arises from a dysfunction in the dramatic period of healthy brain development typically associated with adolescence...
- Investigating the neuropsychological and neuroanatomical changes that occur over the first 2-3 years of illness in patients with first-episode schizophreniaLisa Zipparo
Department of Psychology, Macquarie University, North Ryde, NSW, Australia
Prog Neuropsychopharmacol Biol Psychiatry 32:531-8. 2008..This study explored the concurrent courses of the neuroanatomical and neuropsychological changes that occurred over the first 2-3 years of illness in patients with first-episode schizophrenia (FES)...
- Longitudinal changes in neuroanatomy and neural activity in early schizophreniaThomas J Whitford
The Brain Dynamics Centre, Westmead Millennium Institute and University of Sydney, and Acacia House, Westmead Hospital, New South Wales, Australia
Neuroreport 18:435-9. 2007..These results suggest that first-episode schizophrenia may be associated with abnormally elevated levels of neural synchrony...
- Duration of posttraumatic stress disorder predicts hippocampal grey matter lossKim Felmingham
Brain Dynamics Centre, Westmead Millennium Institute, Westmead Hospital, Australia
Neuroreport 20:1402-6. 2009..This pattern suggests that prolonged PTSD may have cumulative adverse effects on hippocampal volume, highlighting the potential role of genetic-environmental interactions...
- Emotion-elicited gamma synchrony in patients with first-episode schizophrenia: a neural correlate of social cognition outcomesLeanne M Williams
Brain Dynamics Centre, Westmead Millennium Institute and Western Clinical School, University of Sydney, Westmead Hospital, Westmead NSW, Australia
J Psychiatry Neurosci 34:303-13. 2009....
- Neural synchrony in patients with a first episode of schizophrenia: tracking relations with grey matter and symptom profileLeanne M Williams
Brain Dynamics Centre, Westmead Millennium Institute and Western Clinical School, University of Sydney, Westmead, Sydney, Australia
J Psychiatry Neurosci 34:21-9. 2009..We examined relations between 40 Hz Gamma band synchrony and grey matter in patients with schizophrenia at first episode and after 2.5 years...
- Diagnosis-related regional gray matter loss over two years in first episode schizophrenia and bipolar disorderTom F D Farrow
Brain Dynamics Centre, Westmead Hospital, Westmead SCANLab, Department of Academic Clinical Psychiatry, University of Sheffield, United Kingdom
Biol Psychiatry 58:713-23. 2005..We predicted that FEP subjects would show longitudinal reductions in fronto-temporal gray- and white-matter volumes compared with controls. Furthermore, we expected groups to be differentiated by diagnosis-related reductions...
- Grey matter deficits and symptom profile in first episode schizophreniaThomas J Whitford
The Brain Dynamics Centre, Acacia House, Westmead Hospital and Western Clinical School, University of Sydney, Westmead Hospital, Westmead, NSW 2145, Australia
Psychiatry Res 139:229-38. 2005..The results also suggest a possible structural underpinning for the abnormal brain activity typically associated with symptoms of Reality Distortion...
- General and social cognition in first episode schizophrenia: identification of separable factors and prediction of functional outcome using the IntegNeuro test batteryLeanne M Williams
The Brain Dynamics Centre, Westmead Millennium Institute and Western Clinical School, University of Sydney, Westmead Hospital, NSW, 2145, Australia
Schizophr Res 99:182-91. 2008..We determined the presence of separable factors of general and social cognition, their equivalence to the consensus domains identified by the NIMH MATRICS project, and their effectiveness in predicting real world functional outcomes...
- Functional disconnections in the direct and indirect amygdala pathways for fear processing in schizophreniaPritha Das
Neuroscience Institute of Schizophrenia and Allied Disorders, Darlinghurst, NSW 2010, Australia
Schizophr Res 90:284-94. 2007..In this study we tested the hypothesis that schizophrenia is characterized by abnormal functional connectivity in the amygdala network underlying fear perception...
- Neural synchrony and gray matter variation in human males and females: integration of 40 Hz gamma synchrony and MRI measuresLeanne M Williams
The Brain Dynamics Center, University of Sydney and Westmead Hospital, NSW 2145, Australia
J Integr Neurosci 4:77-93. 2005..Sex differences in the profile of cortical synchronization may reflect distinct aspects of evolutionary advantage...
- Rostral anterior cingulate volume predicts treatment response to cognitive-behavioural therapy for posttraumatic stress disorderRichard A Bryant
Brain Dynamics Centre, Westmead Hospital, Sydney, Australia
J Psychiatry Neurosci 33:142-6. 2008..To index the extent to which treatment response in posttraumatic stress disorder (PTSD) is predicted by rostral anterior cingulate cortex (rACC) volume...
- The relationship between frontal gray matter volume and cognition varies across the healthy adult lifespanMolly E Zimmerman
Department of Psychiatry and Human Behavior, Brown Medical School, Providence, Rhode Island, USA
Am J Geriatr Psychiatry 14:823-33. 2006..The goal of the current study is to examine the relationship between age-related changes in regional gray matter volumes and cognitive function in a large, cross-sectional sample of healthy adults across the lifespan...
- Diffusion tensor imaging of the corpus callosum: a cross-sectional study across the lifespanNicole C R McLaughlin
Brown Medical School, Department of Psychiatry and Human Behavior, Providence, RI 02912, USA
Int J Dev Neurosci 25:215-21. 2007..These results define the microstructural development of the white matter across the lifespan. Future studies are required to examine the neurobehavioral correlates of these neuroimaging indices...